Objective: This study discusses the clinical effect of traditional Chinese medicine exercise rehabilitation system (CMTT) on knee surgery patients based on the theory of bone reinforcement and tendon softening. Methods: 80 patients who needed re- habilitation treatment after tibial plateau fracture surgery were randomly divided into control group and observation group, 40 cases in each group. Control group was given routine rehabilitation training, and observation group was given CMTT. The excellent and good rate, bone metabolism indexes [bone alkaline phosphatase (ALP), type I procollagen amino terminal peptide (PINP), β-collagen special sequence (β-CTX), 25-hydroxyvitamin D [25(OH)D], inflammatory factor indexes [C-reactive protein (CRP), interleukin-6 (IL-6), inter- leukin-1β (IL-1β)], oxidative stress indexes [glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), malondialdehyde (MDA)] and bone mineral density were compared between two groups. Results: The excellent and good rate 90.00% in observation group was higher than 62.50% of control group (P<0.05). The levels of ALP and 25 (OH)D of two groups increased after 12 weeks of intervention, and observation group higher than control group. PINP and β-CTX decreased, and observation group lower than control group (P<0.05). CRP, IL-6 and IL-1β of two groups decreased after 12 weeks of intervention, and observation group lower than control group (P<0.05). The MDA level of two groups decreased after 12 weeks of intervention, and observation group lower than control group; GSH-PX and SOD increased, and observation group higher than control group (P<0.05). The T value of proximal tibial bone mineral density of two groups increased after 12 weeks of intervention, and observation group higher than control group (P<0.05). Conclusion: Under the guidance of the theory of bone normalization and tendon flexibility, CMTT can be applied to patients after knee surgery, which can improve bone mineral density, promote bone metabolism and fracture healing, and effectively reduce postoperative inflammation and oxidation reaction, so that patients can recover quickly and early. [ABSTRACT FROM AUTHOR]