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目的探讨基因多态性对先天性心脏病儿童心脏介入手术中舒芬太尼（SUF）药代动力学的影响。方法选择年龄6~72月，ASA分级Ⅱ级并拟行心脏介入手术的患儿168例。使用丙泊酚2 mg·kg-1、SUF 0.3 μg·kg-1及苯磺顺阿曲库铵0.2 mg·kg-1行麻醉诱导，丙泊酚8 mg·kg-1·h-1维持麻醉。采用稀释采样法收集给予SUF后5、10、20、30、45、60、75、90 min的血液标本。使用UHPLC-MS/MS法测定血浆中SUF的药物浓度，并用Phoenix WinNonlinTM软件计算药代动力学参数。基因型检测采用基质辅助激光解析电离飞行时间质谱进行检测。应用SNPStats对基因型数据和药代动力学数据进行分析，选择赤池信息量准则数值最小的模型为最优模型。结果共纳入可能影响SUF药代动力学和药效学相关的靶点、代谢酶、转运体及通路相关的9个基因中30个单核苷酸多态性位点。发现基因ABCG2 rs2054576和OPRM1 rs4870266与SUF药物暴露量相关（P OPRM1 rs2236257与SUF表观分布容积相关（PCYP3A4 rs2246709和OPRM1 rs2236257，rs4870266与SUF药物清除率相关（PABCG2 rs2054576，CYP3A4 rs2246709和OPRM1 rs2236257，rs4870266的基因多态性可显著地影响SUF的药代动力学变化。

The experiment aimed to explore the effects of adding different proportions of Zingiber mioga flavonoids to feed on the growth performance, immune function, plasma biochemical indices and antioxidant function of chicks. Ninety seven-day-old chicks with similar physical conditions were randomly divided into three groups, with 10 replicates per group and three chicks per replicate. The control group was fed a basic diet, while Group Ⅰ and Group Ⅱ were supplemented with 100, 200 mg/kg of Zingiber mioga flavonoids in the basic diet, respectively. The experiment lasted for 35 days. The results showed that from the 1st to the14th day of the experiment, the average daily weight gain of chicks in Group Ⅰ was extremely higher than that of the control group and Group Ⅱ (P<0.01), and the feed to gain ratio was extremely lower than that of the control group and Group Ⅱ (P<0.01). On the 35th day of the experiment, the activity of plasma alanine aminotransferase (ALT) in Group Ⅰ and Group Ⅱ was extremely lower than that of the control group (P<0.01), and the antibody titers against H9 subtype avian influenza virus and Newcastle disease virus (NDV) in the blood were significantly higher than those of the control group (P<0.05). The activity of plasma catalase (CAT) was significantly higher than that of the control group (P<0.05). The plasma total protein (TP) content in Group Ⅱ was significantly higher than that in the control group and Group Ⅰ (P<0.05). On the 35th day, the thymus index and bursa of fabricius index in Group Ⅰ and Group Ⅱ were significantly higher than those of the control group (P<0.05). The study indicates that the addition of an appropriate amount of Zingiber mioga flavonoids to the feed of chicks can improve growth performance, immune function, partial plasma biochemical indices and antioxidant function, with a recommended addition of 100 mg/kg. [ABSTRACT FROM AUTHOR]

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Objective To investigate the types and causes of complications after facial injection with mesotherapy, and to summarize effective prevention and treatment methods. Methods From January 2015 to December 2021, there were 35 patients with bruising, redness, itching, folliculitis and other symptoms due to mesotherapy facial injection were retrospectively analyzed, and the pathogenesis and types of complications were analyzed, symptomatic treatment and systemic anti-inflammatory and anti-allergic treat-ment were taken to observe the treatment effect. Results A total of 35 patients in this group were followed up for 3 to 36 months, 29 cases recovered (82.86%), 4 cases were effective (11.43%), and 2 cases were ineffective (5.71%). Conclusion In view of the complications after facial injection of mesotherapy, symptomatic treatment should be taken in time, and the effect is accurate, which is worthy of clinical promotion and application. [ABSTRACT FROM AUTHOR]

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A patient with major depressive disorder and auditory verbal hallucinations underwent 7 sessions of computer Avatar Therapy Systems (CATS). The Positive and Negative Symptom Scale ( PANSS), Hamilton Anxiety Scale ( RAMA), Hamilton Depression Scale ( HAMD), Belief About Voices March-Revised ( BA VQ-R), and Psychotic Symptom Rating Scales (PSYRATS) were used to evaluate the changes in patients' symptoms before and after treatment. Auditory hallucinations were reported, depression was reduced, and social functioning was re stored after 7 sessions of CATS. CATS has been shown to be effective in treating auditory verbal hallucinations. [ABSTRACT FROM AUTHOR]

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