Search

【目的】探讨内质网应激（ERS）及p53上调凋亡调控因子（PUMA）在5-氟尿嘧啶（5-FU）诱导的肝脏细胞的损伤与凋亡中发挥的作用。【方法】给予10只PUMA基因敲除小鼠（PUMA-KO）和20只野生型小鼠（PUMA-WT）腹腔注射等剂量的5-FU，建立小鼠肝脏损伤模型，其中10只WT小鼠同时给予腹腔注射ERstress抑制剂4-苯基丁酸（4-PBA），对照组10只KO小鼠及20只WT小鼠给予等量生理盐水，造模完成后收集小鼠的血清及肝脏组织，评估肝脏病理损伤程度，检测血清中ALT及AST表达水平以及肝脏组织中PUMA及GRP78表达水平，观察这些指标在不同处理组小鼠的变化。【结果】与WT对照组相比，5-FU组小鼠血清ALT及AST水平明显升高，H&E染色可见点状局灶性坏死，伴出血和炎症，TUNEL染色可见凋亡细胞明显增多（Z=3.78，P

BACKGROUND: In vitro fertilization-embryo transfer is commonly used to solve infertility, but its success rate is not high, the more common reasons are poor endometrial receptivity, poor egg quality, etc. The follicular fluid melatonin can inhibit the aging of the ovary, to a certain extent, can promote the development of embryos, improve the probability of conception, but whether there is a correlation between the two is not known. OBJECTIVE: To explore the correlation between follicular fluid melatonin level and pregnancy rate of single-cycle in vitro fertilization-embryo transfer women. METHODS: A total of 112 female patients who received in vitro fertilization-embryo transfer treatment in the First Affiliated Hospital of Anhui Medical University from December 2020 to April 2021 were selected as the study subjects. They were divided into quartile array (Q1-Q5) according to the follicular fluid melatonin level from low to high. Among them, the melatonin level of group Q1 was < 6.99 ng/L (n=18), that of group Q2 was 7.00-9.99 ng/L (n=26), that of group Q3 was 10.00-11.99 ng/L (n=27), and that of group Q4 was 12.00-13.99 ng/L (n=18); and melatonin levels in group Q5 were 14.00-19.99 ng/L (n=23). Clinical data characteristics of the five groups were compared. Multi-factor Logistic regression was used to analyze the correlation between follicular fluid melatonin level and pregnancy rate of women with single-cycle in vitro fertilization-embryo transfer and embryo transfer. A restricted cubic spline Logistic regression model was established to analyze the dose-response relationship, and the model was evaluated by clinical decision curve. RESULTS AND CONCLUSION: (1) Compared with the study population with the lowest melatonin quintile (Q1), with the increase of melatonin level (Q2-Q5), the levels of egg harvest and pregnancy success were gradually increased, and the body mass index was gradually decreased, and the differences were significant (P < 0.05). (2) Multivariate Logistic regression analysis showed that after adjusting for confounding factors such as global mass index, number of eggs retrieved, luteinizing hormone, estradiol, progesterone and other confounding factors, follicular fluid melatonin level was still independently correlated with pregnancy rate of single-cycle in vitro fertilization-embryo transfer women (OR=1.538, 95%CI: 1.032-1.837, P < 0.05), and there was significant difference in trend test of follicular fluid melatonin level from low to high quintile array (Ptrend < 0.05). (3) The sensitivity test analysis showed that E value was 2.117. Subgroup analysis showed that the study population with higher levels of luteinizing hormone in follicular fluid had a more significant association between follicular fluid melatonin and pregnancy rate in single-cycle in vitro fertilization-embryo transfer women (P interaction=0.008). (4) The results of restricted cubic spline model analysis showed that there was a nonlinear dose-response relationship between follicular fluid melatonin level and pregnancy rate of single-cycle in vitro fertilization-embryo transfer women (P < 0.05), and there was an overall positive correlation between follicular fluid melatonin level and pregnancy rate of single-cycle in vitro fertilization-embryo transfer women. (5) The results of clinical decision curve analysis showed that the follicular fluid melatonin level had important clinical value in predicting the pregnancy rate of single-cycle in vitro fertilization-embryo transfer women. (6) Follicular fluid melatonin level is closely related to the pregnancy rate of single-cycle in vitro fertilization-embryo transfer women, and with the decrease of follicular fluid melatonin level, the pregnancy rate of single-cycle in vitro fertilization-embryo transfer women also decreases. [ABSTRACT FROM AUTHOR]

BACKGROUND: Mesenchymal stem cells are susceptible to senescence during in vitro expansion, which greatly hinders their application in vivo and in vitro. How to improve the replicative senescence of mesenchymal stem cells is an urgent problem to be solved in tissue engineering. OBJECTIVE: To determine whether vascular endothelial growth factor combined with basic fibroblast growth factor can improve the aging of bone marrow mesenchymal stem cells caused by replicative passage. METHODS: Rat bone marrow mesenchymal stem cells were extracted by whole bone marrow adhesion method. Passage 2 cells were selected as normal control group. Passage 7 and later algebraic cells were selected as aging model group. Vascular endothelial growth factor (50 μg/L), basic fibroblast growth factor (10 μg/L), and their combination were administered. Cell proliferation was detected by CCK-8 assay. Cell senescence was observed by β-galactosidase activity staining. Cytoskeleton size and colony formation ability were observed by phalloidine staining and Giemsa staining, respectively, and the levels of senescence-related genes P16, P21, and P53 were detected by qRT-PCR. Gene expression levels of P16, P21, and P53 were tested by qRT-PCR. RESULTS AND CONCLUSION: (1) Vascular endothelial growth factor combined with basic fibroblast growth factor could promote the proliferation of aged bone marrow mesenchymal stem cells, which began to enter the plateau stage on day 9, and the absorbance value of the combined intervention group was significantly higher than that of the model group on day 9 (P < 0.05). (2) The phenotypic markers of the cells in the combined intervention group did not change, and the cell morphology changed from broad to slender. (3) Compared with the model group, the positive rate of β-galactosidase was significantly decreased (P < 0.01); the number of nuclei increased (P < 0.001); the total area of cytoskeleton increased (P < 0.01); colony formation ability was enhanced (P < 0.05); expression level of P16 was decreased (P < 0.01) in the combined intervention group. These results indicate that vascular endothelial growth factor combined with basic fibroblast growth factor can improve the senescence of bone marrow mesenchymal stem cells caused by replicative passage without changing the cell phenotype. [ABSTRACT FROM AUTHOR]

[Objectives] In order to achieve effective prevention and control of banana Fusarium wilt, this study constructed a biocontrol microbiota with inhibitory effect on banana Fusarium wilt. [Methods]The antagonistic strains against the Fusarium oxysporum f. sp. cubense race 4(FOC4)were isolated and screened from suppressive soil to banana Fusarium wilt disease using a dual culture assay. The strains were determined based on the results of 16S rRNA sequence. Indoleacetic acid (IAA) production capacity and biofilm forming ability of these strains were assessed through indoor cultivation experiments. The inhibitory effects of the synthetic microbiota on pathogen were investigated in the co-culture system in vitro and in pot experiments. [Results] The 4 strains showed significant antagonistic effected on the growth of FOC4. The 4 strains were identified as Bacillus sp., Streptomyces sp., Bacillus sp. and Enterobacter sp. based on 16S rRNA. In addition, these strains showed strong IAA production and biofilm formation ability. The synthetic microbiota composed of 4 strains showed the strongest inhibitory effect in vitro. Compared with the control, the inhibition rate of the synthetic microbiota increased by 93.6%. Moreover, the synthetic microbiota was further demonstrated to effectively colonize the rhizosphere of banana plants. In pot experiments, it significantly reduced the pathogen's abundance in the rhizosphere by 92.13%. [Conclusions] A synthetic microbiota composed of 4 bacterial strains was successfully isolated and constructed, which could significantly inhibit the proliferation of banana pathogens under potted conditions, providing certain technical support for the use of beneficial microorganisms to control banana Fusarium wilt. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper summarized the integrated nursing of traditional Chinese and western medicine for a patient undergoing percutaneous coronary intervention (PCI) supported by intra-aortic balloon pump(IABP) for cardiogenic shock acute caused by anterior myocardial infarction. Key issues of nursing included symptomatic nursing, acupoint application, auricular point pressing therapy, oral care with Chinese herbal medicine were carried during the treatment period. The integrated nursing measures were potentially effective to improve the patient’s satisfaction and reduce the risk of complications. (本文总结1例急性前壁心肌梗死致心源性休克患者行急诊经皮穿刺冠状动脉内支架植入术(PCI)及行主动脉内球囊反搏(IABP)后的中西医结合护理方案, 包括对症护理、穴位贴敷、耳穴压豆、中药口腔护理等。中西医结合护理方案能有效提升患者的舒适度, 减少并发症的发生风险。)

Objective To analyze the trend of disease burden of colorectal cancer attributed to alcohol consumption in China from 1990 to 2019 and provide evidence for the colorectal cancer prevention and control in China. Methods Data on colorectal cancer mortality and disability-adjusted life years (DALYs) rates attributable to alcohol from 1990 to 2019 were extracted from the GBD 2019 database. The age-period-cohort (APC) model was used to assess the effects of age, period, and cohort, and the ARIMA model was used to predict the disease burden of colorectal cancer attributable to alcohol in the next 10 years. Results From 1990 to 2019, the number of deaths, crude mortality rate, and crude DALY rate of colorectal cancer attributable to alcohol in China increased from 56 000, 0.47/100 000, and 1433/100 000 in 1990 to 245 000, 1.72/100 000, and 46.57/100 000 in 2019. The age -standardized mortality rate and age -standardized DALY rate increased from 0,66/100 000 and 17.79/100 000 in 1990 to 1.24/100 000 and 32.51/100 000 in 2019, with an average annual increase of 2,16 (1.94-3.89, £=19.95) and 2.07 (L85-230, £=18.22). The death risk of colorectal cancer attributable to alcohol in China reached its peak at 16,61/100 000 (95%CI: 15.98%-17.26%) in the 5-80 years old group from 1990 to 2019, The period effect showed that the death risk RR reached its highest at 142 (95%CI: 138%-1.46%) between 2012 and 2017. The cohort effect showed that the death risk RR increased from 0.30 (95%CI: 0.27%-0.33%) in 1910 to 2.71 (95%CI: 2.18%-3.36%) in 1990. The prediction model showed that the age -standardized mortality rate and DALY rate of colorectal cancer attributable to alcohol in China would continue to rise from 2020 to 2030, Conclusion The burden of colorectal cancer attributed to alcohol consumption among the Chinese population has been on the rise from 1990 to 2019, with significant gender and age differences. Middle aged and elderly men are the main population increasing the disease burden, and health education for both men and middle-aged and elderly people should be strengthened to reduce the burden of colorectal cancer. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the liver histopathological features of chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) and their correlation with serological markers. Methods Clinical data were collected from 137 patients with normal ALT who were treated in Wuxi Fifth People’s Hospital from April 2018 to June 2021, and the differences in liver histopathology and serological markers were analyzed, as well as the correlation between liver histopathology and serological markers. The chi-square test was used for comparison of categorical data between groups, and the Kruskal-Wallis H test was used for comparison of data between multiple groups. A Spearman rank correlation test was performed, and logistic regression was used to perform the multivariate analysis. Results In the ALT ≤20 U/L, 20‍ ‍—‍ ‍29 U/L, and 30‍ ‍—‍ ‍40 U/L groups, the patients with significant inflammatory necrosis (≥G2) accounted for 57.4%, 53.4%, and 75%, respectively, and the patients with significant fibrosis (≥S2) accounted for 63.8%, 62.1%, and 75%, respectively. There was a significant difference in the degree of inflammatory necrosis between the patients with positive or negative HBeAg, the patients with different levels of serum HBV DNA, and the patients with different levels of serum HBV RNA (χ2=10.008, 6.911, and 7.946, all P<0.05）, and there was a significant difference in fibrosis stage between the patients with positive or negative HBeAg and the patients with different levels of serum HBV RNA (χ2=7.996 and 10.874, both P<0.05). The degree of liver inflammation and fibrosis stage were not significantly correlated with serum HBV DNA (rs =0.024, P=0.785； rs =0.039, P=0.652）, while they were significantly correlated with serum HBV RNA (rs =0.222, P=0.009； rs =0.187, P=0.029). The multivariate analysis showed that in CHB patients, positive HBeAg was an independent risk factor for inflammatory necrosis (odds ratio [OR]=-0.302, 95% confidence interval [CI]：-1.160 to 0.386, P=0.002) and fibrosis (OR=-0.387, 95%CI：-1.160 to 0.386, P=0.011). Conclusion There are varying degrees of inflammatory necrosis and fibrosis in the liver of CHB patients with normal ALT, and positive HBeAg is independent risk factor for significant inflammatory necrosis and fibrosis in liver tissue of these patients. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Chinese Institute of Food Science & Technology is the property of Journal of Chinese Institute of Food Science & Technology Periodical Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective　To investigate the prevalence of liver cirrhosis and the changing trend of the disease burden of liver cirrhosis in the Chinese population from 1990 to 2019, and to provide a data reference for formulating the prevention and treatment strategies for liver cirrhosis in China. Methods　The Global Burden of Disease Study 2019 was used to collect the data on the incidence rate, mortality rate, disability-adjusted life years （DALY), years of life lost （YLL), and years lived with disability （YLD） of liver cirrhosis. The Joinpoint regression model was used to analyze the changing trend of disease burden； the age-period-cohort （APC） model was used to evaluate age, period, and cohort effects； R software BAPC package was used to predict future changes in disease burden. Results　From 1990 to 2019 in China, there were increases in the numbers of liver cirrhosis cases and prevalent cases in the general population, as well as in the male and female populations, while there was a reduction in the number of deaths. From 1990 to 2019, the standardized incidence rate, standardized prevalence rate, and standardized mortality rate of liver cirrhosis in the Chinese population showed a downward trend, with a mean annual reduction of 0.62%（ 95% confidence interval［ CI］： −0.74% to −0.50%, t= 9.99, P<0.001), 0.44% （95%CI： −0.53% to −0.35%, t=13.18, P<0.001), and 3.02% （95%CI： −3.12% to −2.93%, t=7.58, P< 0.001), respectively. From 1990 to 2019, the standardized DALY, YLL, and YLD rates of liver cirrhosis in the Chinese population also showed a downward trend, with a mean annual reduction of 3.27% （95%CI： −3.37% to −3.18%, t=6.22, P<0.001), 3.32% （95%CI： −3.42% to −3.22%, t=9.31, P<0.001), and 1.42% （95%CI： −1.49% to −1.34%, t=4.93, P<0.001), respectively. From 1990 to 2019, the incidence rate of liver cirrhosis in the Chinese population first increased and then decreased with age, while the mortality rate showed an increasing trend, and the risks of disease onset and death showed a decreasing trend with time and birth cohort. The predictive model showed that the standardized incidence rate, prevalence rate, mortality rate, and DALY rate of liver cirrhosis in China will show a decreasing trend from 2020 to 2030. Alcohol was the most important risk factor for both male and female populations, followed by medication. Conclusion　The disease burden of liver cirrhosis in China shows a decreasing trend from 1990 to 2019, with sex and age differences, especially in the middle-aged male population. Effective measures should be taken for intervention. [ABSTRACT FROM AUTHOR]

Copyright of Science & Technology of Food Industry is the property of Science & Technology of Food Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

儿童肾外肾母细胞瘤较为罕见,其症状及体征多无特异性,辅助检查亦无特殊表现,部分 病例可伴发畸形有助于提示诊断。本文回顾性分析首都医科大学附属北京儿童医院2014—2018年收 治的3例肾外肾母细胞瘤患儿临床资料,并结合国内外文献,总结该疾病的临床特点及治疗经验。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探讨主动呼吸循环技术 (ACBT) 联合有氧运动在胸腔镜肺结节切除围手术期患者中的 作用。方法 选取 2022 年 4-12 月该院收治的接受胸腔镜肺结节切除患者 52 例, 采用随机数字表法分为治疗 组和对照组, 每组 26 例。对照组接受常规术后护理及 ACBT 处理, 治疗组在常规术后护理及 ACBT 处理基础 上联合有氧运动训练。比较2组患者干预前后肺功能[包括用力肺活量 (FVC)、最大呼气流量 (PEF) 等]、呼吸 困难程度(呼吸困难量表评级)、胸腔引流管留置(留管)及术后住院时间、继发性肺炎发生情况等。结果 2组 患者继发性肺炎发生情况、呼吸困难量表评级比较, 差异均无统计学意义(P>0.05); 治疗组患者留管及术后住 院时间均明显短于对照组, 差异均有统计学意义 (P<0.05); 对照组患者干预后 FVC、PEF均较干预前呈上升 趋势, 但差异均无统计学意义 (P>0.05); 治疗组患者干预后 FVC、PEF 均较干预前明显提升, 且治疗组患者干 预后 FVC、PEF均明显高于对照组, 差异均有统计学意义 (P<0.05)。结论 ACBT 联合有氧运动可缩短胸腔 镜肺结节切除患者术后留管及术后住院时间, 提高患者肺功能, 促进患者术后康复 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shanghai Jiaotong University (Medical Science) is the property of Journal of Shanghai Jiaotong University (Medical Science) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The scenario data of Coupled Model Intercomparison Project Phase 6 (CMIP6) are processed by Delta method in statistical downscaling method. Based on the centralized root mean square error (RMSE), correlation coefficient (R), standard deviation (STD) and interannual variability skill score (Ts), comprehensively evaluate the simulation ability of scenario data from 10 CMIP6 models on the extreme temperature index in Shandong, and select models with better simulation results. The results indicate that:In the simulation of extreme temperature indices TXx and TNx that characterize intensity, after downscaling, more than 50% of the models simulate that the median absolute deviation of extreme temperature index in Shandong is closer to the observed value than before downscaling, in the simulation of extreme temperature indices TR, SU, FD and ID that characterize frequency, more than 60% of the models absolute deviation medians are closer to the observations than before downscaling.Using the ranking method, the simulation ability of the 10 models was compared. The CMCC-ESM2 score was 178 points, NorESM2-MM score was 191 points, and TaiESM1 score was 191 points. Therefore, these three models are preferred models. The error percentage of extreme temperature indices simulated by the ensemble mean of optimized models is lower than that of all models.After optimization, the absolute value of error percentage of TXx, TNx, TR and ID decreased from 4.2%, 2.2%, 28.67% and 14.3% to 3.3%, 1.8%, 23.58% and 9.7%, the error percentage of SU was within ± 1% before and after optimization. [ABSTRACT FROM AUTHOR]

Objective To analyze the mortality of gastric cancer attributed to tobacco and the changes of disability adjusted life year (DALY) in China from 1990 to 2019, to provide scientific basis for the prevention and control of gastric cancer attributed to tobacco. Methods The data of gastric cancer mortality and DALY rate attributed to tobacco in China from 1990 to 2019 were extracted from the global disease burden database in 2019. Join point software was used to analyze the changing trend of mortality and DALY rate, and age-period-cohort (APC) model was used to analyze age, period, and cohort effects. Results Compared with 1990, the number of gastric cancer deaths, mortality, DALY, and DALY rates attributed to tobacco in 2019 showed an upward trend, with increases of 59.69%, 32.80%, 42.85%, and 18.89%, respectively, while standardized mortality and standardized DALY rates showed a downward trend, with a decrease of 34.90% and 39.53%, respectively. From 1990 to 2019, the age mortality and DALY rate of gastric cancer began to increase in the 30-year-old population, the standardized mortality rate reached the highest in the age group of 80 to 84 years and then decreased, and the DALY rate reached the peak in the age group of 70 to 74 years and then decreased. The global change (Net Drift) and 95% confidence interval of gastric cancer mortality attributed to tobacco in China from 1990 to 2019 were -1.83 (95%CI: -2.02 to -1.65), -1.80 (95%CI: -2.01 to -1.60), and -2.50 (95%CI: -2.92 to -2.08), respectively. Conclusion Although the disease burden of gastric cancer attributed to tobacco in China showed a downward trend from 1990 to 2019, the disease burden should not be ignored. Attention should be paid to the elderly and men, and health education, early screening, early diagnosis, and early treatment of gastric cancer should be further strengthened. [ABSTRACT FROM AUTHOR]

Pipeline transportation is the first choice for oil and gas transportation due to its smooth and continuous transportation, large transportation volume and low freight. Pipeline leakage detection is an important guarantee to maintain its safe operation. In order to improve the accuracy of leakage detection and positioning, a software and hardware solution for oil pipeline leakage detection is designed based on the principle of negative pressure wave, and a leakage monitoring software is developed. The system is installed at both ends of the oil pipeline, and can complete the functions of pipeline status information collection, data transmission, leakage alarm and positioning functions. The global positioning system is used to unify the system time of the head and end data acquisition system to eliminate the dynamic response time difference of the head and end pressure sensors. The practical application results show that the system can accurately judge the leakage of oil pipeline and determine the leakage point. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective：To observe the immediate effect of radial extracorporeal shock wave (rESWT) on pain, emotion and brain function in primary dysmenorrhea(PDM)during menstruation. Method：Totally 39 subjects were recruited and randomly assigned to the ESWT group(n=20) and the placebo group(n=19). The short- form McGill pain questionnaire(SF- MPQ), the COX menstrual symptom scale (CMSS), the self-rating anxiety scale(SAS) and the self-rating depression scale(SDS) were used to assess the patients' dysmenorrhea intensity, symptoms, anxiety and depression. Fractional low frequency amplitude (fALFF) was obtained by rs-fMRI. The differences of SAS, SDS and fALFF among in non-menstrual(days 6- 12 of menstrual cycle)were assessed before and after intervention during menstruation(during the first 48 hours of menstruation). The differences of SF- MPQ and CMSS before and after intervention during menstruation were also evaluated. Result：After treatment, the SF-MPQ, CMSS and SAS during menstruation were all decreased compared with those before treatment(P<0.001) in both groups, there was no significant difference between two groups; the SDS scores had no significant difference within and between groups. The fALFF of the left middle temporal gyrus after treatment was lower than that of the non-menstrual period in ESWT group(P<0.001). Conclusion：A single radial shockwave treatment did not significantly improve pain intensity, pain symptoms, anxiety, depression, and the value of fraction amplitude of low frequency fluctuation in primary dysmenorrhea during menstruation. [ABSTRACT FROM AUTHOR]

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Geography Teaching is the property of Geography Teaching Editorial Office, East China Normal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The Chishan REE deposit is located in southwest of western Shandong uplift area. It is a hard rock and ultra-large type light rare earth deposit. Previous studies have found that the rare earth mineralization is closely related to the Chishan alkaline complex. The genesis of the rock mass and the formation age of the deposit are still scientific issues that need attention. Therefore, a systematic study on the petrography, geochronology, trace element and isotope geochemistry of the Chishan alkaline complex was carried out in this paper, and Re-Os isotopic dating of the deposit was carried out for the first time using the molybdenite. The results show that the zircon U-Pb age of the Chishan alkaline complex is 119. 9±0. 9 Ma, and the molybdenite Re-Os isotope age is 120. 0±1. 8 Ma, indicating that the diagenesis and mineralization are the products of Early Cretaceous magmatism. The Chishan alkaline complex rock mass is characterized by rich alkali and poor magnesium, belonging to alkaline rock series. The total amount of rare earth elements is high, and the REE pattern is characterized by a strong enrichment of light rare earth elements as a right-leaning direction. The trace elements are enriched in Ba, Th, U and Nd, and depleted in Nb, Ta, Zr and Hf. The whole rock ( 87Sr/ 86Sr)i value is 0. 706 36-0. 711 68, the εNd(t) value is from -9. 70 to -8. 82, and the zircon εHf(t) value is from -6. 75 to -12. 22, indicating that the magma source area has the characteristics of mantle enriched in EMⅠ. In summary, the diagenesis and mineralization of the Chishan REE deposit should be formed in an extensional tectonic setting, which is closely related to the enriched mantle upwelling caused by the destruction and reduction of North China Craton lithosphere in Early Cretaceous. [ABSTRACT FROM AUTHOR]

Copyright of University Chemistry is the property of Peking University, College of Chemistry & Molecular Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Urban green development is the inherent requirement for achieving high-quality development. Scientific evaluation of urban green development level and accurate identification of influencing factors of green development are key scientific issue to promote urban green economy transformation and the coordinated development of “resource-environment-economy”. The urban green development level measurement index system was comprehensively constructed from the aspects of social and economic development, resource endowment and consumption, environmental pressure and governance, public life and social status, technological innovation and policy, etc.; and then the DPSIR-TOPSIS model and obstacle model were combined to analyze the dynamic changes of green development levels of Urumqi in Xinjiang from 2007 to 2021, and the restricted factors that affect the green development were identified. The results show that ① the green development status of Urumqi has continued to improve from 2007 to 2021, its levels keep on significantly rising and green development gets some effective achievements. ② The driving force, state, impact and response indexes of green development are on the rise, and the difference in growth rates seems significant, while the pressure index takes on a slight decline; green development policies and measures have responded positively, but the pressure on resources and environment still exists. ③ The main factors affecting green development of Urumqi are not the same during different periods. From 2007 to 2013, the urban road area, Engel coefficient, the disposable income of urban residents, and the proportion of tertiary industries are the main factors; but from 2014 to 2021, GDP growth rate, unit GDP power consumption, natural population growth rate, and total annual water supply factors are the main factors. In summary, taking consideration of the characteristics of “resources rich, industrial agglomeration, and ecological fragility” in Urumqi, some suggestions such as accelerating green low-carbon transformation, promoting green technology innovation, advocating green consumption, and real-time adjustment of green development ideas are put forward. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Irrigation & Drainage is the property of Journal of Irrigation & Drainage Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Ophthalmology & Otorhinolaryngology is the property of Eye & ENT Hospital of Fudan University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To probe into the effects of different doses of febuxostat in the treatment of gout with hyperuricemia, and to analyze the related factors affecting the efficacy. METHODS: A total of 146 patients with gout and hyperuricemia admitted into the hospital ( from Mar. 2020 to Feb. 2022) were extracted to be divided into the group A and group B via the random number table method, with 73 cases in each group. Group A was treated with low-dose febuxostat (40 mg/d), group B was given high-dose febuxostat (80 mg/d). The treatment was continued for 12 weeks, the efficacy of two groups was evaluated, the occurrence of adverse drug reactions was recorded, and the compliance rate, levels of uric acid and serum levels of myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were compared before and after treatment. The uric acid compliance rate of patients with different clinical characteristics was compared, and t-Logistic regression model was used to analyze the influencing factors of uric acid compliance rate. RESULTS: There was no significant difference in the total effective rate [89. 04% (65/73) vs. 91. 78% (67/73)] and uric acid compliance rate [54. 79% (40/73) vs. 57. 53% (42/73)] between the group A and group B (P>0. 05). After treatment, the levels of serum uric acid, MPO, TNF-α and IL-6 in two groups decreased significantly compared to before treatment, the differences were statistically significant (P<0. 05), yet there was no significant difference between two groups (P>0. 05). During the treatment, there were no obvious adverse drug reactions in two groups. There were statistically significant differences in the uric acid compliance rate in patients with different drinking status, exercise conditions, liver function and whether to consume alcohol (P<0. 05). Logistic regression analysis showed that drinking water <2 000 mL/d, exercise <5 weeks/ time, alcohol consumption and abnormal liver function were independent risk factors for gout with hyperuricemia and uric acid control (P<0. 05). CONCLUSIONS: The effect of different doses of febuxostat on the efficacy of patients with gout with hyperuricemia is not significant, and all of them could inhibit the expression of inflammatory factors and achieve significant uric acid-lowering effect with high safety. Water intake, exercise status, alcohol consumption and liver function are important factors affecting its efficacy. It is recommended to enhance disease management according to individual circumstances, thus improving the efficacy and prognosis. [ABSTRACT FROM AUTHOR]

Copyright of Computer Measurement & Control is the property of Magazine Agency of Computer Measurement & Control and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Prataculturae Sinica is the property of Acta Prataculturae Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Environmental Science & Technology (10036504) is the property of Editorial Board of Environmental Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)