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Objective: To observe the effects of Bobath therapy combined with low-frequency repetitive transcranial magnetic stimulation on motor function, neurological function and balance ability in stroke patients with hemiplegia. Methods: The study subjects were 148 stroke patients with hemiplegia who were admitted to our hospital from May 2020 to May 2022. According to the method of random number table, they were divided into control group (Bobath therapy, 74 cases) and study group (low-frequency repetitive transcranial magnetic stimulation combined with Bobath therapy, 74 cases). The balance ability [Berg Balance Scale (BBS)],neurological function [National Institutes of Health Stroke Scale (NIHSS)], daily living self-care ability [modified Barthel Index (MBI)],motor function [Fugl-Meyer upper limb motor function assessment scale (FMA-UE), Fugl-Meyer lower limb motor function assessment scale (FMA-LE)], coagulation function [prothrombin time (PT), fibrinogen (FIB), D-Dimer (D-D), activated partial thromboplastin time (APTT)] changes were observed in the two groups. Results: 20d after treatment, NIHSS score decreased and MBI score increased in both groups, and the degree of change in the study group was greater than that in the control group (P＜0.05). The scores of FMA-UE and FMA-LE in the two groups at 20 d after treatment increased, and the study group was higher than the control group (P＜0.05). The BBS score of the two groups at 20 d after treatment increased, and the study group was higher than the control group (P＜0.05). FIB, APTT,D-D and PT of the two groups at 20 d after treatment decreased, and the study group was lower than the control group (P＜0.05)Conclusion: Low-frequency repetitive transcranial magnetic stimulation combined with Bobath therapy for stroke patients with hemiplegia can improve their coagulation function, recover their neurological function, and then improve their balance and motor function, and improve their daily living ability. [ABSTRACT FROM AUTHOR]

Objective: To investigate the predictive value of ventricular modified Graeb score (mGS score) combined with serum fibroblast growth factor receptor-1 (FGFR-1) and pentraxin 3 (PTX3) for poor prognosis in patients with intraventricular hemorrhage (IVH) after external ventricular drainage. Methods: 109 patients with IVH who received external ventricular drainage treatment from the First Hospital of Hebei Medical University from February 2020 to February 2022 were selected. Glasgow Outcome Scale score (GOS) was used to evaluate the prognosis of patients at 3 months after discharge. According to GOS score, the patients with IVH were divided into poor prognosis group (51 cases) and good prognosis group (58 cases). The mGS scores were evaluated, and serum FGFR-1 and PTX3 levels were detected before surgery. Multivariate Logistic regression analysis was used to analyze the factors affecting the poor prognosis of patients with IVH after external ventricular drainage. Receiver operating characteristic curve (ROC) was drawn to analyze the value of mGS score combined with serum FGFR-1 and PTX3 in predicting poor prognosis in patients with IVH after external ventricular drainage. Results: The preoperative mGS score and serum PTX3 level in the poor prognosis group were higher than those in the good prognosis group (P＜0.05), and serum FGFR-1 level was lower than that in the good prognosis group (P＜0.05). Complicated with cerebral hernia, high mGS score and high PTX3 were risk factors for poor prognosis in patients with IVH after external ventricular drainage (P＜0.05), and high FGFR-1 was protective factor (P＜0.05). The area under curve of combined mGS score and serum FGFR-1 and PTX3 predicting poor prognosis in patients with IVH after external ventricular drainage was 0.894, which was higher than that predicted by above indicators alone. Conclusion: The mGS score and serum PTX3 level increased, and serum FGFR-1 level decreased in patients of poor prognosis with IVH after external ventricular drainage. Combined mGS score, serum FGFR-1 and PTX3 has high prognostic value in patients with IVH after external ventricular drainage. [ABSTRACT FROM AUTHOR]

Objective To observe the prevalence of osteoporosis and to investigate the associations between bone mineral density (BMD) and serum biochemical markers in maintenance hemodialysis patients，and to explore the risk factors of osteoporosis． Methods One hundred and twenty-five patients undergoing hemodialysis were selected． The general data and dialysis-related information were collected． The levels of 25 － hydroxyvitamin D，bone-specific alkaline phosphatase，and BMD at the calcaneus were measured． Statistical analysis was performed using the SPSS version 19. 0． P ＜ 0. 05 was accepted as statistically significant． Ｒesults The prevalence of osteoporosis was 48% and 25-hydroxyvitamin D deficiency was 30. 4% in maintenance hemodialysis patients． No statistically difference of the prevalence of osteoporosis was found between the genders． BMD was significantly lower in post-menopausal women than in pre-menopausal women (P ＜ 0. 001) ． 25-hydroxyvitamin D was significantly lower in female patients than in male patients (P = 0. 026)． BMD was significantly lower in tubulointerstitial nephritis patients than in chronic glomerulonephritis patients (P = 0. 001)． BMD was lower in patients with sedentary lifestyle (P ＜ 0. 001) ． BMD was negatively correlated with age and duration of hemodialysis (r = － 0. 387，P ＜ 0. 001，r = － 0. 190，P = 0. 034，respectively) ． Older age， post-menopause，low body weight，sedentary lifestyle，and renal transplantation were risk factors for osteoporosis in maintenance hemodialysis patients． Conclusion The prevalence of osteoporosis and 25 － hydroxyvitamin D deficiency are high in maintenance hemodialysis patients，but no association is found between them． Older age，post-menopause，low body weight，sedentary lifestyle， and glucocorticoid and immunosuppressant therapy after renal transplantation are risk factors for osteoporosis in maintenance hemodialysis patients． [ABSTRACT FROM AUTHOR]

In order to increase the visibility and contrast effect of air pollutants, and more visually demonstrate the impact of the meteorological characteristics on the air pollutants concentrations, this paper firstly conducts a periodical analysis of PM2.5 pollutant concentration in Ningbo. The data are obtained by the extracting the seasonal variations of PM2.5 pollutant concentration. Secondly, a reliability lest on Ningbo meteorological data and air pollution data is carried out. The results show that the confidence interval is over 90% . Thirdly, the paper analyzes the data concerning the wind power and direction in Ningbo, using Python language to conduct a polar coordinate transformation, and also an analyzes the visibility test on wind power and direction. Finally, by using Python language, a demonstration of the PM2.5, PM10, SO2, NO2, O3 and CO concentrations through the 3D coordinate system has been completed. After the four steps, we conclude that through reliability test, polar coordinative transformation, frequency comparison, by directly using the air and meteorological data, visibility contrast and correlation analysis could be positively completed. [ABSTRACT FROM AUTHOR]

Objective: To explore the association between single nucleotide polymorphisms of TMTC1 gene and schizophrenia. Methods: A total of 207 patients with schizophrenia and 186 healthy controls were included in the study. SNPscanTM multiplex SNP genotyping technology was used to perform genetic typing of 7 SNP loci in the TMTC1 gene. Differences in allele frequencies, genotypes, and haplotypes were compared, and the correlation between SNP loci and susceptibility to schizophrenia was analyzed under different genetic models. Results: The genotype distribution of the 7 SNP sites loci is consistent with Hardy-Weinberg equilibrium. There was no statistically significant difference in the allele and genotype frequency distribution of the 7 loci between the two groups (P > 0.05). The polymorphisms of the 7 SNP loci under different genetic models are not associated with the risk of schizophrenia (P > 0.05). However, there is a high degree of linkage disequilibrium (LD) between rs10332 and rs16934358, rs10332 and rs2023588, rs16934358 and rs2023588, rs16934358 and rs7503. Conclusion The polymorphisms of the TMTC1 gene at rs7503, rs10332, rs2023588, rs16934358, rs2113879, rs679087, and rs4931240 sites are not associated with schizophrenia. Further analysis is needed by increasing the sample size and screening for new SNP loci. [ABSTRACT FROM AUTHOR]

Considering the influence of gusset thickness, gusset material, shear connector and loading scheme, quasistatic experiments of eight aluminum alloy gusset joints (AAG joints) under out-of-plane bending moment were carried out. The deformation characteristics, failure modes, bearing capacity, ductility and energy dissipation of AAG joints were obtained. The experimental results reveal that the behavior during the loading process can be divided into five stages ： elastic stage, bolts slipping stage, holt hole bearing stage, bearing capacity degradation stage and failure stage. The failure modes mainly include buckling of members and block shear rupture of gusset plates, which are related to the thickness of plate and the flange of member. The hysteresis of the AAG joint specimens are not very full due to the influence of bolts slipping. Comprehensively considering the skeleton curve, deformation ductility coefficient and energy dissipation coefficient of specimens，the AAG joint with thicker plate can provide relatively better bearing capacity, ductility and energy dissipation. [ABSTRACT FROM AUTHOR]

Objective To explore the applicability of IBS and FSI methods in the identification of full sibling relationship in Yunnan population. Methods A total of 448 pairs of full siblings and 1 020 pairs of unrelated individuals were genotyped for 19 STR loci, and CIBS and CFSI were calculated. Descriptive statistics, normality test and t-test were performed for lgCFSI values and CIBS values of whole sibling pairs and unrelated individual pairs using SPSS 25.0 software. χ2 test was used for counting data. Results The lgCFSI and CIBS values of the whole sibling group and the unrelated individual group were in normal distribution. The difference between the unrelated individual group and the full sibling group was statistically significant in both the IBS and FSI methods. The statistical comparison of the difference between the three cutt-offs dividing methods in the old and new standards is statistically significant. For 19 autosomal STR loci, the system power of the three methods in the two standards were 0.750 0, 0.556 5 and 0.662 5, respectively, while the system power of the Yunnan population in this study were 0.740 5, 0.510 9 and 0.662 1, respectively. Conclusion The new standard has a high value of forensic medicine application in the identification of full sibling relationship in Yunnan. The IBS method and FSI method based on 19 autosomal STR loci detection system can effectively reduce the risk of misjudgment in the identification of full sibling relationship. [ABSTRACT FROM AUTHOR]

Objective To investigate the practical application of IBS method in the full sibling testing． Methods PowerPlex R 21 System kit was used to amplify the 19 STR loci （D3S1358， D6S1043，D13S317， Penta E，D16S539，D18S51，D2S1338，CSF1PO，Penta D，TH01，vWA，D21S11，D7S820，D5S818， TPOX，D8S1179，D12S391，D19S433，FGA） from the 234 pairs of determined full siblings and 200 unrelated individuals of Han population in Yunnan province，and ABI3130 genetic analyzer automatic detection and Gene Mapper ID v3.2 software were used for STR genotyping．The typing results were calculated on the basis of the IBS method （SF/Z JD0105002-2014） ．Results The rate of full siblings was 82.91% ， and it was higher than 75% in the standard. 17.09% of the samples could not give tendentious opinions. The scores from 13 to 22 had 65 pairs of unrelated individuals， and it accounted for 32.50%.There were 135 pairs of less than 13 points that accounted for 67.50%. Conclusion The application of IBS method in the identification of full siblings in Yunnan has a high value in forensic medicine. [ABSTRACT FROM AUTHOR]

In order to study the aging performance of graphene rubber composite modified asphalt, the short-term aging and longterm aging of graphene rubber composite modified asphalt samples were simulated by RTFOT and PAV. Rubber asphalt and matrix asphalt were used as comparative tests to analyze the conventional and micro properties of asphalt samples before and after aging. The experimental results show that the penetration ratio, softening point difference and viscosity aging index of graphene rubber modified asphalt were stronger than those of rubber asphalt and base asphalt. In the micro test, the sulfoxide index of graphene rubber composite modified asphalt was small, and the aging resistance was improved obviously. In the fluorescence microscope scanning, the addition of graphene formed a network structure in the rubber asphalt, and it was more stable than rubber asphalt after aging. [ABSTRACT FROM AUTHOR]

Objective To analyse the genetic relationship between MAOA μ-VNTR polymorphism and physical aggressive behavior（AB） in Yunnan Han and Yi populations and to test whether there are gene-risk factors interactions in MAOA μ-VNTR polymorphism and degrees of education， marital status， drinking and smoking. Methods Health controls were made between 495 male with AB and another 527 males， MAOA μ-VNTR genotyping was performed using fluorescent-labeled primers combined with capillary electrophoresis typing. Data statistics were performed using SPSS software. Results MAOA μ-VNTR polymorphism has no direct correlation with AB and has no interaction with the four potential risk factors. The risk factors for AB are the history of smoking and low levels of education. Conclusion There was no correlation between MAOA μ-VNTR polymorphism and physical aggression behavior in Yunnan Han and Yi nationalities；the low education levels and smoking history of the two groups are risk factors for physical aggression behavior. [ABSTRACT FROM AUTHOR]