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目的构建131I标记的肝癌核酸纳米火车（NT），并探讨其作为肝癌靶向新型核素载体的可能性。方法三条核酸短链经退火处理后自组装形成核酸长链并采用氯胺T法进行放射性碘标记得到131Ⅰ-NT，纸层析法测纳米粒子的标记率及放射化学纯度，检测标记产物在不同温度（4 ℃、室温）及不同的储存溶剂（PBS、纯血清）中的体外稳定性。通过激光共聚焦显微镜检测肝癌细胞对纳米粒子的特异性摄取情况，分别测定131Ⅰ-NT与人肝癌细胞HepG2、正常肝细胞 L02 结合后细胞的放射性摄取率。通过尾静脉注射131Ⅰ-NT至HepG2荷瘤小鼠体内，进行生物分布研究。结果131Ⅰ-NT标记率为（93.05±0.74）%，纯化后放化纯度为（98.35±0.32）%。4 ℃储存条件下，标记产物在PBS和纯血清中24 h后的放化纯度分别为（92.77±0.04）%、（89.43±0.2）%。131Ⅰ-NT分别与两种细胞孵育2 h后，HepG2细胞的放射性摄取率明显高于L02细胞。尾静脉注射131Ⅰ-NT后，荷瘤小鼠体内 30 min、1 h、2 h肿瘤部位每克组织放射性摄取值分别为（4.90±0.55）%ID/g、（10.12±0.32）%ID/g、（4.25±0.31）%ID/g，T/M比值相应为7.33±2.04、36.54±12.72、44.93±7.90。结论成功构建了131I标记的长链核酸纳米火车，具有较好体外稳定性，对HepG2细胞及HepG2细胞荷瘤小鼠模型具有较高的靶向性，显示131Ⅰ-NT可能是一种具有潜力的靶向人肝癌的核素载体，为肝癌靶向核素诊疗提供新思路。

The Transformer-based image captioning models have shown remarkable performance based on the powerful sequence modeling capability. However, most of them focus only on learning deterministic mappings from image space to caption space, i. e., learning how to improve the accuracy of predicting "average" captions, which generally tends to common words, repeated phrases and single sentence, leading to the severe mode collapse problem. To this end, this paper combined the conditional variational encoder with the Transformer-based image captioning model, and proposed the sentence-level and word-level diverse image captioning models, respectively. The proposed models introduced the global and sequential latent embedding learning based on the evidence lower bound (ELBO), which promoted the diversity of Transformer-based image captioning. Quantitative and qualitative experiments on MSCOCO dataset show that both models have the ability of learning one-to-many projections between the image space and the caption space. Compared with the state-of-the-art COS-CVAE, the proposed method with 20 samples improves the CIDEr and Div-2 scores by 1.3 and 33% respectively in the case of 20 samples, improves the CIDEr and Div-2 scores by 11.4 and 14%, respectively in the case of 100 samples. The proposed method can fit the distribution of ground-truth captions well, and achieve a better balance between diversity and accuracy. [ABSTRACT FROM AUTHOR]

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Traditional subspace clustering methods usually replace the matrix rank function by the matrix kernel norm to recover the original low rank matrices. However, in the process of minimizing the matrix kernel norm, these algorithms pay too much attention to the calculation of the large singular values of the matrix, resulting in inaccurate estimation of the matrix rank. To this end, this paper analyzed the long tail distribution of matrix singular values and proposed a low rank subspace clustering model based on truncated Schatten-p norm. The proposed model fitted the long tail distribution of matrix singular va-lues well and toke full account of the contribution of small singular values to the process of low rank matrix recovery. The mo-del could make full use of small singular values to fit the long tail distribution of matrix singular values, ultimately achieved an accurate estimation of matrix rank function and improved the performance of subspace clustering. The experimental results show that, compared with the WNNM-LRR and BDR subspace clustering algorithms, the proposed method improves the clustering accuracy by 11% and 8% on Extended Yale B dataset, respectively. The proposed method can better fit the distribution of data singular values and construct the similarity matrices more accurately. [ABSTRACT FROM AUTHOR]

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Under the background of land use control and ecological environment zoning control, how to ensure the land demand for large-scale renewable energy development has become an urgent problem to be solved in the implementation of renewable energy development plans. The implementation of renewable energy development plans in China is still facing dilemmas from land space constraints, land use conflicts, ecological environment constraints, and ‘Not in My Backyard’ (NIMBY) effect. In the central and eastern regions, land space constraints are manifested in the scarcity of renewable energy land sources. Land sources for large-scale renewable energy development should be expanded mainly through the three-dimensional development of land space and the reuse of contaminated and mine waste lands. In the western region, although there is a large area of unused land, the effective supply of land for large-scale renewable energy development is still insufficient due to the constraints of the ecological protection red line or the weakness of the power grid, energy storage, and other infrastructures. The synergy between renewable energy development planning and land space planning and the control of ecological environment zoning should be achieved mainly by establishing a renewable energy planning area system and improving the ecological protection red line system. Renewable energy power generation, such as wind energy, photovoltaic energy, and solar thermal utilization, has an impact on the ecological environment mainly by changing the way of land use, negatively affecting biodiversity, water and soil conservation, and other ecosystem services. To avoid or reduce the impact of renewable energy development on the ecological environment, China should realize the synergy between the goals of renewable energy development and ecological environmental protection, and establish a sound management system for renewable energy development with the collaboration of the competent departments of ecological environment, natural resources, and energy, as well as a management mechanism for renewable energy development that is compatible with the requirements of ecological environmental protection. The construction and operation of renew⁃ able energy power generation facilities may have adverse impacts on community residents in terms of noise, lighting, landscape, open space, leisure, and entertainment, and thus produce the NIMBY effect. To address the NIMBY effect of renewable energy development and utilization, standards should be scientifically formulated to regulate the adverse impacts of renewable energy power generation on the surrounding residents, improve relevant public participation mechanisms, respect stakeholders, and establish a benefit-sharing mechanism for renewable energy development to achieve a win-win situation. [ABSTRACT FROM AUTHOR]

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In order to improve the adaptability of the dredger to the short discharge, the existing submerged pump and the in board pump of the large cutter suction dredger "Xin Haiyan" are taken as the research objects. In order to ensure the universality of the pump impeller and keep the axial projection of the impeller unchanged, the blade profile of the short discharge impeller was designed by combining the cutting law and the wrap angle transformation method, and the designed blade is twisted, the performance and flow field distribution of the newly designed short discharge impeller and the direct cutting impeller are compared and analyzed by numerical simulation. Finally, the applicable conditions of the dredger with existing impeller and the short discharge impeller were compared and predicted respectively. The results show that the performance of the underwater pump and the inboard pump with optimized short discharge impeller can meet the design requirements. Compared with the cutting impeller, the design point efficiency is increased by 1.1% and 2.9% respectively, and the flow field distribution is more uniform; For the pursuit of production, the suitable discharge for the optimized short discharge impeller is 0.15 km to 2 km; Consider economy, the suitable discharge for the short discharge impeller is 0.8 km to1km and1.6 km to 2.85 km respectively; The dredging efficiency under the short discharge condition is improved with the optimized short discharge impeller [ABSTRACT FROM AUTHOR]

Due to geographical factors and historical reasons, urban underground circular cavity “many”, “ dense”, “ chaotic” situation is more and more serious, geological radar circular cavity scanning image analysis is not clear. Based on the whole process of geological radar scanning and detection, the whole process of radar scanning underground circular cavity was divided into three stages. The relationship between horizontal distance and echo delay in each stage was established. The changes of circular cavity geological radar scanning images under different buried depths and different radii were systematically analyzed. Combined with the detection example, the scientific explanation of the imaging mechanism of underground circular cavity geological radar was realized. It is concluded that the left side of the symmetric axis of the underground circular cavity radar scanning image is a monotonically decreasing continuous concave function, and the thickness increases from constant to stable. The right side of the symmetric axis is a monotonically increasing continuous concave function, and the thickness decreases from stable to constant. With the increase of buried depth and radius, the curvature of the curve decreases, and the curve image tends to be relaxed. The characteristics of the curve reflect the trend of increasing openness. [ABSTRACT FROM AUTHOR]

Copyright of China Surfactant Detergent & Cosmetics (1001-1803) is the property of China Surfactant Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective To establish and evaluate the rat model of type 2 diabetic nephropathy with osteoporosis. Methods SD rats were fed with high glucose and high fat diet for 4 weeks. Then they were injected with streptozotocin ( STZ 35 mg / kg) intraperitoneally. The changes of blood glucose urine volume urine protein CA-P and other biochemical indexes were observed. Bone mineral density and biomechanical strength were measured using dual energy X-ray absorptiometry. The kidney and bone tissue were collected for pathological detection. Results The levels of blood glucose urine volume and urine protein in rats of the model group increased gradually compared with those in the normal group after feeding with high glucose and high fat diet. After injecting streptozotocin intraperitoneally for 4 weeks the levels of blood glucose urine volume and urine protein in rats of the model group increased significantly compared with those in the normal group. At the 8th week the levels of blood glucose urine volume urine protein and urine Ca and P in rats of the model group were significantly higher than those of the normal group and the difference was statistically significant. Bone mineral density and bone strength in rats of the model group were lower than those of the normal group. Pathological findings showed that the rats in the model group had renal hypertrophy glomerular capillary loop hypertrophy mesangial matrix increase renal lesions and bone lesions such as sparseness thinning and continuous interruption of bone trabecula. Conclusion The rat model of type 2 diabetic nephropathy with osteoporosis can be established by intraperitoneal injection of streptozotocin combined with high glucose and high fat diet for 8 weeks. The model has the characteristics of high glucose? polyuria? increased urine protein decreased bone density increased glomerulopathy and bone absorption. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical effect of visual function training combined with topicamide eye drops in the treatment of pseudo myopia. Methods: 400 cases of children with pseudomyopia admitted to the ophthalmology department of the army characteristic medical center of the Chinese people's liberation army and the ophthalmology department of Chongqing you baby women's and children's hospital were selected as the research objects from February 2019 to Agust 2019. They were randomly divided into the control group and the observation group (n=200). The control group was treated with eye drops to relieve eye fatigue, while the observation group was treated with visual training combined with compound topicamide eye drops. The visual acuity, axial length, diopter, positive and relative adjustment, and visual fatigue score were measured and compared between two groups before and after treatment. Results: After 2 month and 6 months of treatment, the visual acuity of the children in the observation group was (0.75± 0.05) and (0.81± 0.04), which was significantly higher than that of the control group (P<0.05). The diopters of children were (+0.05± 0.50) and (+0.06± 0.48), respectively, and the improvement was significantly better than that of the control group (P<0.05). The test results of the positive relative regulation quantity were (-1.98± 0.07) and (-2.51± 0.24) respectively, which were significantly better compared with the control group (P<0.05). The visual perception binocular visual function of two groups improved significantly, and the visual function recovery of observation group was significantly higher than that of control group (P<0.05). The investigation of visual fatigue showed that the scores of visual fatigue in the observation group were (6.90± 0.89) and (3.91± 0.89), which were significantly lower than those in the control group (P<0.05). Conclusion: Visual function training combined with compound topicamide eye drops could effectively improve children's naked eye vision, and promote diopter, positive relative adjustment and V visual perception function, which reduced visual fatigue and prevented myopia. [ABSTRACT FROM AUTHOR]

To investigate the clinical effect of visual function training combined with topicamide eye drops in the treatment of pseudo myopia. 400 cases of children with pseudomyopia admitted to the ophthalmology department of the army characteristic medical center of the Chinese people's liberation army and the ophthalmology department of Chongqing you baby women's and children's hospital were selected as the research objects from February 2019 to Agust 2019. They were randomly divided into the control group and the observation group (n=200). The control group was treated with eye drops to relieve eye fatigue, while the observation group was treated with visual training combined with compound topicamide eye drops. The visual acuity, axial length, diopter, positive and relative adjustment, and visual fatigue score were measured and compared between two groups before and after treatment. After 2 month and 6 months of treatment, the visual acuity of the children in the observation group was (0.75± 0.05) and (0.81± 0.04), which was significantly higher than that of the control group (P<0.05). The diopters of children were (+0.05± 0.50) and (+0.06± 0.48), respectively, and the improvement was significantly better than that of the control group (P<0.05). The test results of the positive relative regulation quantity were (-1.98± 0.07) and (-2.51± 0.24) respectively, which were significantly better compared with the control group (P<0.05). The visual perception binocular visual function of two groups improved significantly, and the visual function recovery of observation group was significantly higher than that of control group (P<0.05). The investigation of visual fatigue showed that the scores of visual fatigue in the observation group were (6.90± 0.89) and (3.91± 0.89), which were significantly lower than those in the control group (P<0.05). Visual function training combined with compound topicamide eye drops could effectively improve children's naked eye vision, and promote diopter, positive relative adjustment and V visual perception function, which reduced visual fatigue and prevented myopia. [ABSTRACT FROM AUTHOR]

The traditional frame support structure dissipates seismic energy through the plastic deformation of members. After the earthquake, the residual deformation is often too large and the repair cost is high, which endangers the reasonable service life of the structure. Based on this, this paper proposes a new type of self-restoring viscoelastic energy damper which combines stable stiffness, self-restoring and high energy consumption. The viscoelastic damper is composed of viscoelastic material, disc spring system and section steel through reasonable structural measures. The viscoelastic material shear deformation is used to provide the energy consumption capacity, and the disc spring is always pulled to provide the reset function. Based on the Mooney Rivlin material model and working mechanism, the restoring force model of the energy damper is established, and the finite element software ANSYS is used to simulate it. The results show that the self-restoring viscoelastic energy damper designed in this paper has stable stiffness, good energy dissipation capacity and reset function, and the finite element calculation results are in good agreement with the theoretical recovery model results. The maximum deviation of ultimate bearing capacity is 4. 8 %, and the maximum deviation of hysteretic energy dissipation capacity is 7. 2 %. The proposed recovery model and numerical model can provide basic theory for the design of this damper. [ABSTRACT FROM AUTHOR]

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