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目的观察静脉输注利多卡因对腹腔镜疝修补术患儿苏醒期躁动的影响。方法选择年龄在2～4岁之间，美国麻醉医师协会体格分级（ASA）Ⅰ～Ⅱ级择期在全麻下行腹腔镜疝修补术的患儿60例为研究对象，按照随机数字表法分为空白对照组（C组），右美托咪定阳性对照组（D组），利多卡因处理组（L组），每组20例。主要观察指标包括WATCHA量表躁动评分，拔管后躁动发生率，补救加药次数；次要观察指标包括术中平均七氟烷吸入浓度，术后早期疼痛评分，拔管时间，恢复室停留时间，48h内术后镇痛药物曲马多使用量，结果① D组、L组患儿术后WATCHA躁动评分均低于C组； D组、L组患儿躁动发生率分别为15%、20%，均低于C组70%；补救加药人次均为10%，低于C组55%；采用Bonferroni校正，两两对比差异有统计学意义 （PPPP

目的探讨乳腺癌患者全麻术后恶心呕吐（PONV）的危险因素。方法选择乳腺癌全身麻醉患者530例，按照患者术后是否有恶心、呕吐对530例患者的相关病史及麻醉病历分别作单因素和多因素Logistic回归分析，评价乳腺癌患者全麻术后恶心呕吐的危险因素。结果530例患者中，发生PONV有101例，发生率为19.06%。多因素分析发现：术前禁饮禁食时间、麻醉维持方式、术中低血压、有无使用止吐药、有无使用曲马多、术后使用阿片类药物镇痛与乳腺癌术后恶心呕吐发生相关（P

文章对两种双频率波段的光纤无线通信（Radio-Over-Fiber,ROF）系统模型进行了仿真分析。首先基于文献实验,实现了使用一个马赫-曾德调制器直接调制双频率波段的ROF系统模型,然后改为使用两个马赫-曾德调制器分别调制两个波段的系统模型。结果表明,在误码率BER=10-9,光纤长度为55 km的情况下,对于40 GHz频段,改进后的系统比改进前的系统性能提高5 dBm;从敏感度曲线上也可以看出,改进后的系统性能更稳定。

Copyright of Journal of Practical Medicine / Shiyong Yixue Zazhi is the property of Journal of Practical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Anhui Agricultural Sciences is the property of Journal of Anhui Agricultural Sciences Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ordnance Equipment Engineering is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China / Zhongguo Yiyuan Yongyao Pingjia yu Fenxi is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the mechanisms by which chlorogenic acid combined with forsythoside regulates cytokine storms through network pharmacology and in vitro experiments. Methods The targets of chlorogenic acid and forsythoside were predicted using Swiss Target Prediction, PharmMapper, SEA, and TCMSP databases. Targets related to cytokine storms were retrieved from GeneCards, OMIM, DRUGBANK, and DisGeNET databases. Intersection targets were identified and depicted in a Venn diagram. A protein interaction network was constructed using the STRING database and Cytoscape software. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using the DAVID database. A cytokine storm model was established in RAW264.7 macrophages induced by lipopolysaccharide (LPS). Cell viability was assessed using the Cell Counting Kit-8(CCK-8) method. Nitric oxide (NO) levels in the supernatant were measured by the Griess method. Levels of inflammatory cytokines, tumor necrosis factor-alpha(TNF-α), interleukin-6(IL-6), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2(COX-2) were determined by enzyme-linked immunosorbent assay (ELISA). The expression of TNF receptor-associated factor 4 (TRAF4), TNF receptor-associated factor 6 (TRAF6), and phosphatidylinositol 3-kinase 3(PIK3C3) proteins were analyzed by Western blot. Results Network pharmacology analysis identified eight core network targets for the treatment of cytokine storms with chlorogenic acid and forsythoside, including serine/ threonine-protein kinase (AKT1), albumin (ALB), hypoxia-inducible factor 1-alpha (HIF1A), IL-6, matrix metalloproteinase-9 (MMP-9), peroxisome proliferator-activated receptor gamma (PPARG), tyrosine kinase (SRC), and Toll-like receptor 4(TLR4). Key pathways included the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) signaling pathway. In vitro experiments showed that compared to the control group, levels of NO, TNF-α, IL-6. iNOS, and COX-2 were significantly higher in the model group (P<0.001). After treatment, levels of NO, TNF-α, IL-6, INOS, and COX-2 significantly decreased compared to the model group(P< 0.001). The combined treatment of chlorogenic acid and forsythoside (11) more effectively reduced inflammatory indicators compared to single treatments (P<0.001). Protein expression of TLR4, TRAF6, PIK3C3, and phosphorylation levels of PIK3C3 significantly decreased in the treatment group compared to the model group. Conclusion Chlorogenic acid combined with forsythoside synergistically suppresses the expression of pro-inflammatory cytokines and regulates cytokine storms, potentially through the TLR4/TRAF6/PIK3C3 signaling pathway. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to improve the cooling effect of the oriented silicon steel constant annealing process, a three-dimensional numerical simulation of the air-liquid two-phase flow inside the air atomization nozzle was conducted. The computational fluid dynamics method was used to analyze the effects of air pressure and liquid flow rate on the velocity and liquid phase volume fraction of the flow field inside the nozzle. The numerical results are in good agreement with the experimental test values, and the maximum error is less than 10% . The results show that when the water flow rate is constant, with the increase of air pressure, the velocity inside the nozzle gradually increases, and the liquid phase volume fraction decreases. The velocity distribution at the nozzle outlet became less uniform, while the liquid phase volume fraction distribution become more uniform. When the air pressure is constant, with the increase of water flow rate, the velocity inside the nozzle gradually decreases, and the liquid phase volume fraction increases. The velocity distribution at the nozzle outlet become more uniform, while the liquid phase volume fraction distribution become less uniform. When the air water pressure ratio is 1. 1, the nozzle cooling uniformity is better, and the optimal working conditions for nozzle cooling uniformity are air pressure of 0. 2 MPa and water flow rate of 180 L / h. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Cancer Biotherapy is the property of Editorial Office of Chinese Journal of Cancer Biotherapy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of East China University of Science & Technology is the property of Journal of East China University of Science & Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Feed Industry is the property of Liaoning Provincial Institute of Agricultural Mechanization and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Resources Development & Market is the property of Sichuan Resource Development & Market Magazine Co., Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In this paper, 131 species of Zingiberaceae and Costaceae from China were collected, and their ornamental uses were summarized, a hierarchical model of ornamental value of Zingiberaceae was established by AHP, and 28 species of Zingiberaceae with good ornamental, adaptability and popularization were selected. [ABSTRACT FROM AUTHOR]

BACKGROUND: Osteoporosis has a high incidence, leading to fracture and other complications. However, existing drugs have great side effects and are difficult to meet the clinical application. OBJECTIVE: To explore the effect and potential mechanism of fucoxanthin on osteoporosis induced by glucocorticoid. METHODS: Primary rat osteoblasts were inoculated in 6-well plates. When the cell fusion reached 80%, the cells were divided into four groups: the control group was cultured alone for 24 hours, the glucocorticoid group was intervened with dexamethasone for 24 hours, the fucoxanthin group was intervened with fucoxanthin for 24 hours, and the glucocorticoid + fucoxanthin group was intervened with dexamethasone and fucoxanthin at the same time for 24 hours. After intervention, cell proliferation, apoptosis, intracellular reactive oxygen species level, and protein expression of apoptosis-related proteins, bone formationrelated proteins, and nuclear factor erythroid-2-related factor 2 were detected. RESULTS AND CONCLUSION: Cell counting kit-8 results showed that the cell viability was decreased in the glucocorticoid group compared with the control group (P < 0.05) but increased in the glucocorticoid+fucoxanthin group compared with the glucocorticoid group (P < 0.05). JC-1 mitochondrial membrane potential staining and flow cytometry assay showed that the percentage of apoptosis increased in the glucocorticoid group compared with the control group (P < 0.05) but decreased in the glucocorticoid+fucoxanthin group compared with the glucocorticoid group (P < 0.05). Western blot assay showed that compared with the control group, the protein expression of BAX and cleaved poly (ADP-ribose) polymerase was elevated in the glucocorticoid group (P < 0.05), and the protein expression of BCL2, type I collagen α1 peptide chain, alkaline phosphatase, osteocalcin, and RUNX2 was decreased in the glucocorticoid group (P < 0.05). Compared with the glucocorticoid group, the protein expression of BAX and cleaved poly (ADP-ribose) polymerase was decreased (P < 0.05), and the protein expression of BCL2, type I collagen α1 peptide chain, alkaline phosphatase, osteocalcin, and RUNX2 was elevated (P < 0.05) in the glucocorticoid+fucoxanthin group. Fluorescent probe assay showed an increase in reactive oxygen species level in the glucocorticoid group compared with the control group (P < 0.05) and a decrease in reactive oxygen species level in the glucocorticoid+fucoxanthin group compared with the glucocorticoid group (P < 0.05). Immunofluorescence staining and western blot assay showed that the protein expression of nuclear factor erythroid-2-related factor 2 in the glucocorticoid group was decreased compared with that in the control group (P < 0.05); and the protein expression of nuclear factor erythroid-2-related factor 2 in the glucocorticoid+fucoxanthin group was elevated compared with that in the glucocorticoid group (P < 0.05). To conclude, fucoxanthin can improve glucocorticoid-induced osteoblast apoptosis and the expression of bone formation-related molecules by activating nuclear factor erythroid-2-related factor 2. [ABSTRACT FROM AUTHOR]

BACKGROUND: Diabetic osteoporosis is gaining public attention. However, few studies have reported the effect of a high-glucose environment on the osteogenic differentiation of human umbilical cord mesenchymal stem cells and the corresponding therapeutic strategies. OBJECTIVE: To investigate whether vitamin D3 can restore the osteogenic differentiation potential of human umbilical cord mesenchymal stem cells in a high)glucose environment. METHODS: The viability of human umbilical cord mesenchymal stem cells was detected by CCK-8 assay to screen the appropriate vitamin D3 intervention concentration. Under the high-glucose environment, RT-qPCR, western blot assay, immunofluorescence, JC-1 mitochondrial membrane potential, alizarin red staining, and β-galactosidase staining were used to evaluate the osteogenic differentiation potential, intracellular reactive oxygen species accumulation, mitochondrial membrane potential alteration, and cell senescence of human umbilical cord mesenchymal stem cells after vitamin D3 intervention. The underlying mechanism was also discussed. RESULTS AND CONCLUSION: (1) Vitamin D3 significantly promoted the proliferation of human umbilical cord mesenchymal stem cells in the range of 0.1 μmol/L to 1 mmol/L. (2) High-glucose environment down-regulated the mRNA and protein level expressions of osteogenic-related genes α1-I collagen, alkaline phosphatase, Runt-associated transcription factor 2, and osteocalcin in human umbilical cord mesenchymal stem cells, which induced oxidative stress and cellular senescence. (3) Vitamin D3 at an intervention concentration of 10 μmol/L significantly restored the osteogenic phenotype of human umbilical cord mesenchymal stem cells under high-glucose conditions and attenuated intracellular oxidative stress and cellular senescence by activating the Nrf2/HO-1 signaling pathway. (4) These findings suggested that the osteogenic differentiation ability of human umbilical cord mesenchymal stem cells was reduced in the high-glucose environment, and vitamin D3 could partially improve their osteogenic differentiation ability and reduce cell damage. [ABSTRACT FROM AUTHOR]

on postoperative recovery in elderly patients with coronary artery disease (CAD) who have undergone percutaneous coronary intervention (PCI), and its impact on collateral circulation and endothelial function. Methods A total of 208 elderly CAD patients treated with PCI from January to December, 2021 were randomly divided into two groups: control group (48 patients) receiving routine nursing care combined with ECP, and observation group (48 patients) receiving aerobic rehabilitation training combined with ECP. Cardiopulmonary function indicators, endothelial function, collateral circulation, exercise tolerance indicators, and quality of life were assessed before and after the intervention. Results After 3 months of intervention, the observation group showed significant improvements in cardiopulmonary funetion indicators such as sub-threshold metabolic equivalents, peak oxygen uptake, peak oxygen pulse, and sub-threshold metabolic equivalents compared to the control group (P<0.05). The observation group also demonstrated higher values in heart function indicators such as left ventricular ejection fraction, cardiac output, and maximum heart rate (P<0.05). Endothelial function indicators, including flow mediated brachial artery endothelium-dependent dilation and brachial artery endothelium independent dilation, and collateral circulation scores were significantly better in the observation group (P<0.05). The observation group exhibited lower scores in exercise tolerance indicators like heart rate - blood pressure product, perceived fatigue grade, and Borg scale, and had longer exercise duration (P<0.05). The quality of life scores were also significantly higher in the observation group compared to the control group (P<0.05). Conclusion Aerobic rehabilitation training combined with ECP for elderly CAD patients post-PCI significantly enhances recovery of cardiopulmonary function, improves cardiac collateral circulation and endothelial function, boosts exercise tolerance, and elevates quality of life. This effective rehabilitation approach has significant clinical application value. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Jilin University (Medicine Edition) is the property of Jilin University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Environmental Science & Technology (10036504) is the property of Editorial Board of Environmental Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Preventive Medicine is the property of Modern Preventive Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective: To discuss the method for establishing the rat models of irritable bowel syndrome (IBS) by chronic water avoidance stress (WAS) method, and to evaluate its feasibility. Methods: Thirty male Wistar rats were randomly divided into control group (n=10) and model group (n=20). The rats in model group were induced by WAS method for 1 h everyday, lasting for 10 consecutive days; the rats in control group underwent no interventions. After modeling, the general conditions and body weights of the rats in two groups were observed and recorded. The elevated plus maze (EPM) test was used to detect the percentages of the number of open arm entries (OE) and the time spent in open arms (OT) of the rats in two groups; the abdominal withdrawal reflex (AWR) test was used to assess the visceral sensitivity of the rats in two groups; electrocardiography was used to detect the heart rate variability (HRV) of the rats in two groups; electromyography (EMG) of the external oblique muscle was used to detect the colorectal pain sensitivity thresholds of the rats in two groups; multi-channel physiological signal recorder was used to monitor the slow wave frequency of the colon of the rats in two groups. Results: There were no death rats in both groups during the modeling period. After modeling, the rats in model group exhibited poor mental status, reduced spontaneous activity, hypoactivity, disordered and dull fur, irritability, and unclean anal areas; whereas, the rats in control group showed no significant changes in the mental state, spontaneous activity, fur, and perianal area. Compared with control group, the body weight of the rats in model group was significantly decreased (P<0. 05). The EPM test results showed that compared with control group, the OE percentage and OT percentage of the rats in model group were significantly decreased (P<0. 01). The AWR test results showed that 12 rats in model group scored ≥3 points, indicating that the successful rate in creating the visceral pain models was 60%. Compared with control group, the low frequency (LF) signals and the ratio of LF/high frequency (HF) of the rats in model group were significantly increased (P<0. 01), and the HF was significantly decreased (P<0. 05). The EMG results showed that compared with control group, the coloretal pain sensitivity threshold of the colon of the rats in model group was significantly decreased (P<0. 01), and the slow wave frequency of the colon was significantly increased (P<0. 01). Conclusion: The WAS method for establishing the rat model of IBS effectively demonstrates the changes in behavior and mental state, increased the visceral sensitivity, accelerated colonic slow wave frequency, and autonomic nervous system imbalance; the WAS method can serve as an effective modeling approach for observing and evaluating the related drugs and interventions on treatment of IBS. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Functional Materials / Gongneng Cailiao is the property of Chongqing Functional Materials Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)