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随着全球120多个国家陆续宣布碳中和目标，可再生能源资源不足地区、国家如何实现碳中和成为研究的焦点。新加坡可再生能源匮乏，如何在应对气候变化的同时满足国内能源需求，促进可持续发展一直是新加坡的重要课题之一。新加坡电力需求分布在居民、商业、交通和工业四大部门，通过历史数据分析各部门能源需求的变化规律，以碳中和为目标，2050年能源需求为约束，提出新加坡各部门的能源转型方向，并据此预测碳中和目标下新加坡电力需求。再通过模型分析新加坡2050年电力供应方式，规划结果显示，新加坡电力供应方式将从气电为主转变为太阳能、生物质和氢能等可再生能源为主。但由于新加坡可再生资源潜力不足，电力和氢能均需进口，以中国—新加坡和澳大利亚—新加坡为例，对陆上远距离输电、跨海远距离输电和海运输氢经济性进行对比分析，计算结果表明全球能源互联网框架下的陆上远距离输电经济性最优，度电成本为8.8美分/kWh；进口液氢就地发电其次，成本为15美分/kWh；海上远距离电力进口成本最高，达17美分/kWh。

In this study, 12 radish materials with excellent quality were selected from 78 radish materials by sensory evaluation of spiciness, sweetness, texture, hollow, smoothness and scar. Subsequently, LC-MS was used to identify and analyze the components and contents of glucosinolate in the fleshy roots of 12 radish materials. Finally, the correlation between total glucosinolate and single glucosinolate was studied by principal component analysis. The results showed that the 12 radish materials selected by sensory evaluation included 2 long-white materials, 3 round-white materials, 3 long-red materials and 4 green-skin materials. A total of 12 glucosides were identified in the tested materials, including 8 aliphatic glucosides (GRA, GIB, GRH, GRE, GER, GBN, PRO, GAL) and 4 indole glucosides (GBR, NGBS, 4HGBS, 4MGBS). The highest content of total glucosinolates was F1005 (22.947 μmol/g), and the lowest content was W1063 (3.518 μmol/g) in the tested materials. In terms of composition, the main aliphatic glucosinolate was GRH, and the main indole glucosinolate was NGBS. In addition, aliphatic glucosinolate accounted for 95.78%-99.87% of the total glucosinolate content and indole glucosinolate accounted for 0.16%-4.22% of the total glucosinolate content in the tested materials. The highest glucosinol content of all materials was GRH, which accounted for 61.91%-93.54% of the total glucosinol content. The total glucosinol content was positively correlated with GRH and GRE content, and negatively correlated with NGBS content, and there were different degrees of correlation between single glucosinol content. In summary, three materials with high content of sulforaphane precursor glucoside GRA (F1060, F1078 and W1044) were screened in this study, and three materials with low content of glucoside GRH, the main spicy substance, were W1063, F1030 and W1044, respectively. The results will provide the basis for cultivating new varieties of high quality radish. [ABSTRACT FROM AUTHOR]

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Rural development needs to undergo traceable and innovative reforms in relevant systems in response to the requirements of new urbanization, especially in the land management system in rural areas, where there are many problems that contradict the development of new urbanization. Nowadays, the task of promoting new urbanization can provide guidance for the continuous completion of new rural construction in rural areas. Therefore, based on the background of new urbanization, the demand for rural land management system reform was explored, the compatibility between rural land management and new urbanization was analyzed, the problems in rural land management system were pointed out, and constructive optimization strategies were proposed for related issues. [ABSTRACT FROM AUTHOR]

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Objective·To explore the association between high myopia and life quality among children. Methods·Cross-sectional study method was adopted in this study. Highly myopic children aged 4‒10 from 16 districts in Shanghai were enrolled through Shanghai Child and Adolescent Large-scale Eye Study-High Myopia Registration Study. Baseline data for spherical equivalent after cycloplegia and questionnaire data in 2020 were collected. Emmetropic children aged 4‒10 from 16 kindergartens and elementary schools in Jing'an District and Pudong New Area were enrolled. The uncorrected visual acuity, corrected visual acuity and spherical equivalent without cycloplegia were measured through myopia screening in schools, and the questionnaire on quality of life was filled out. Quality of life was measured by the Strengths and Difficulties Questionnaire (SDQ) and EuroQol Five Dimensions Questionnaire Visual Analogue Scale (EQ-VAS). After describing and testing the differences in variable distributions between the highly myopic children group and the emmetropic children group, the differences in life quality between the two groups, and the association between spherical equivalent and life quality scores of the highly myopic children were examined by a linear regression model. Results·A total of 193 children with high myopia and 209 children with emmetropia were enrolled. There were statistically significant differences in age [(9.58±0.94) years vs (7.63±1.50) years, P<0.001] and gender distribution (46.6% males vs 62.7% males, P=0.001) between the highly myopic children and emmetropic children. After adjusting for age and gender, it was found that there was no statistically significant difference in SDQ score between the highly myopic children and emmetropic children (β = 0.313, 95%CI -0.723‒1.349, P=0.553), but the EQ-VAS score in the highly myopic children was lower than that in the emmetropic children (β=-3.805, 95%CI -6.593‒ -1.017, P=0.008). There was no significant relationship between spherical equivalent and SDQ score (β=0.297, 95%CI -0.035‒0.628, P=0.079) and EQ-VAS score (β=0.579, 95%CI -0.330‒1.489, P=0.211) in the highly myopic children. Conclusion·In children with high myopia, self-evaluated overall health status reflected by EQ-VAS score is poorer compared with that in children with emmetropia. However, the EQ-VAS score is not associated with the degree of high myopia. [ABSTRACT FROM AUTHOR]

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Primary liver cancer（PLC） has the features of insidious onset and difficulties in early diagnosis, with limited and ineffective therapeutic options. Chimeric antigen receptor（CAR） T-cell therapy is a genetically modified T-cell therapy that recognizes tumor-specific antigens and activates T cells to exert a tumor-killing effect. CAR T-cell therapy has made great progress in the treatment of hematological tumors and has achieved a good clinical effect in the field of solid tumors in recent years, and although CAR T-cell therapy has developed from the first to the fifth generation, there are still many challenges in the field of solid tumors. This article comprehensively reviews the mechanisms of CAR T-cell therapy for PLC and related research advances, including the main targets such as GPC3, AFP, MUC1, and NKG2D in CAR T-cell therapy for PLC, CAR T-cell therapy for PLC and oncolytic virus, and combined treatment with immune checkpoint inhibitors, as well as the advances in the biological, preclinical, and clinical studies on these targets and treatment modalities and the challenges and solutions for CAR T-cell therapy in the treatment of PLC, so as to provide a reference for the future clinical development of CAR T-cell therapy in liver cancer. [ABSTRACT FROM AUTHOR]

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