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Objective To study the role of plasma proBDNF level in patients with primary Sjogren's syndrome (pSS) with depressive symptoms, and to explore related factors, so as to provide evidence for early intervention. Methods A total of 42 pSS patients and 81 healthy controls were investigated with self-made general information questionnaire and PHQ-9 scale, and 42 pSS patients were investigated and scored with Coping style questionnaire (SCSQ) and social support rating scale （SSRS). European Antirheumatic Association pSS Disease Activity Scale (ESSDAI) was used to evaluate the disease activity of pSS. After informed consent was obtained, 3- 5 ml peripheral blood was collected to detect the level of proBDNF. Results The increase of plasma proBDNF level in patients with pSS complicated with depressive symptoms was the most significant (P < 0.05), and less social support was a risk factor. Conclusion ProBDNF may be involved in the pathogenesis of pSS with depressive symptoms, and these patients need more social support. [ABSTRACT FROM AUTHOR]

Objective To investigate the mortality and related risk factors of 68 cases of CADM- ILD. Methods We collected the clinical and laboratory data of 68 cases of CADM- ILD and analyzed the mortality and related risk factorsof prognosis．Re s ults Female was more common，male: female 1:1.72，onset age: 38- 73，the course of disease was from 1 month to 7 years，55.88% of them were complicated with infection. The incidence rate of fungal infection was 16.17%.The mortality of CADM- ILD for half a year，one year and five years were 25%，32.5% and 48.2% respectively. By COX single factor regression analysis of death- related risk factors,hypoproteinemia, decreased lymphocyte and down- regulation of CD3+ CD4+ T cells were risk factors for poor prognosis in the patients with CAMD- ILD，and multivariate regression analysis showed that CD3+ CD4+ T cell was an independent risk factor for poor prognosis. Conclusion The death rate of CADM- ILD is high，the rapid progression of CADM- ILD is poor prognosis，CD3+ CD4+ T lymphocyte is an independent risk factor for death. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical effect of total glucosides of paeony combined with adalimumab injection on the treatment of rheumatoid arthritis with anti rheumatoid drug. Methods: 86 cases with rheumatoid arthritis who were treated in our hospital were selected and randomly divided into the experiment group and the control group, with 43 cases in each group. The patients in the control group were treated with adalimumab injection, and the patients in the experiment group were treated with total glucosides of paeony capsules on the basis of the control group. Then the morning stiffness time, erythrocyte sedimentation rate (ESR), rheumatoid factor (FR) and clinical curative effect of patients in the two groups were observed and compared. Results: Compared with before treatment, the morning stiffness time, erythrocyte sedimentation rate (ESR) and rheumatoid factor (FR) levels in the two groups decreased (P < 0.05); compared with the control group after treatment, the morning stiffness time, erythrocyte sedimentation rate (ESR) and rheumatoid factor (FR) level in the experiment group were lower (P<0.05), while the the clinical effective rate was higher (P<0.05). Conclusion: Total Glucosides of paeony combined adalimumab injection can reduce invalid antirheumatic drugs for rheumatoid arthritis patients of ESR, FR levels and improve the clinical symptoms, and the clinical curative effect is better. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical effect of total glucosides of paeony combined with adalimumab injection on the treatment of rheumatoid arthritis with anti rheumatoid drug. Methods: 86 cases with rheumatoid arthritis who were treated in our hospital were selected and randomly divided into the experiment group and the control group, with 43 cases in each group. The patients in the control group were treated with adalimumab injection, and the patients in the experiment group were treated with total glucosides of paeony capsules on the basis of the control group. Then the morning stiffness time, erythrocyte sedimentation rate (ESR), rheumatoid factor (FR) and clinical curative effect of patients in the two groups were observed and compared. Results: Compared with before treatment, the morning stiffness time, erythrocyte sedimentation rate (ESR) and rheumatoid factor (FR) levels in the two groups decreased (P < 0.05); compared with the control group after treatment, the morning stiffness time, erythrocyte sedimentation rate (ESR) and rheumatoid factor (FR) level in the experiment group were lower (P<0.05), while the the clinical effective rate was higher (P<0.05). Conclusion: Total Glucosides of paeony combined adalimumab injection can reduce invalid antirheumatic drugs for rheumatoid arthritis patients of ESR, FR levels and improve the clinical symptoms, and the clinical curative effect is better. [ABSTRACT FROM AUTHOR]

Objective To understand Luo County grassroots medical workers to essential medicines cognition. Methods A questionnaire survey method of grassroots medical workers Luo County random survey questionnaires were distributed and 200 copies．Results The questionnaire response rate was 98%. From the survey results, grassroots medical workers to essential drugs awareness is not high, but most of grassroots medical workers for basic drug-related attitudes and behaviors more positive. Conclusion Improving the Luo County grassroots medical workers to essential drugs awareness is necessary. [ABSTRACT FROM AUTHOR]