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为研究钢管超高性能混凝土在标准火灾下的受力性能和破坏机理，建立了钢管超高性能混凝土柱的耐火有限元模型，并重点对比分析了超高性能混凝土与部分其他类型混凝土的热工参数及高温下本构关系的不同对构件温度和耐火极限等的影响，结果表明：钢管超高性能混凝土构件的核心混凝土温度明显高于相应的普通钢管混凝土或钢管高强混凝土构件的核心混凝土温度，且对于不同配合比的超高性能混凝土构件，其核心混凝土温度场也存在一定差异；高温下钢管对核心超高性能混凝土的约束作用可以忽略不计；对于不同长细比的构件，超高性能混凝土热工参数的取值对构件耐火极限的影响程度几乎不变，但不同荷载比下会有所变化，且荷载比是影响钢管超高性能混凝土耐火极限的主要影响因素。在上述工作的基础上，基于平均温度的耐火计算方法，给出了超高性能混凝土等效强度和等效弹性模量折减系数的计算方法以及考虑不同超高性能混凝土热工参数取值的钢管超高性能混凝土柱平均温度和耐火承载力计算公式，并验证了公式的合理性。该研究将为钢管超高性能混凝土的防火设计提供参考。

《钢管混凝土结构技术规范》(GB 50936—2014)[1]是基于CECS 254:2012、CECS 28:2012和CECS 159:2004等行业技术规程制定的,包含了实心、空心、圆形及多边形截面钢管混凝土构件的承载力设计公式。在收集大量的试验数据的基础上,给出了规范中圆形及方形钢管混凝土构件轴压承载力设计公式以及CECS159:2004中方形钢管混凝土构件轴压承载力设计公式的计算模式不确定性的统计参数。并利用一次二阶矩法对这些公式进行了可靠度分析。分析了钢材种类、混凝土强度等级、活荷载类别、荷载比对构件可靠度的影响。结果表明,这些设计公式满足"统一标准"中对二级房屋建筑结构的可靠指标的要求。

【目的】以PTMAc-PEG-PTMAc三嵌段（PPP）水凝胶为吡非尼酮（PFD）药物缓释载体，评价其药物缓释性能。观察PFD载药水凝胶对人眼Tenon′s囊成纤维细胞（HTF）增殖抑制作用。【方法】制备PPP水凝胶；研究其溶胀率及其影响因素；光学显微镜观察水凝胶（载药与空载）中人眼Tenon′s囊成纤维细胞（HTF）的形态学改变；直接接触法进行PPP载药水凝胶进行体外释药实验。通过测定浓度、计算累积药物释放量，绘制出两种水凝胶体外药物释放曲线。CCK-8法检测不同浓度不同时间点水凝胶材料对细胞活力的影响及载药水凝胶体外抑制HTF增殖。【结果】PPP水凝胶成胶稳定。扫描电镜显示水凝胶呈现三维立体网孔状结构。水凝胶具有溶胀特性。溶胀率随水凝胶材料浓度增加而减少。在体外释药试验显示在前4d有明显的药物突释，此后缓慢释药直至第14天达到平衡。增加载药浓度，减少凝胶体积将明显增加药物累积缓释量；显微镜观察PPP水凝胶有抑制HTF细胞黏附作用；PPP水凝胶与HTF相互作用24、48、72、96h观察细胞活力分别为85.7%、93.0%、82.0%、81.6%，水凝胶不同方位HTF细胞形态不尽相同；水凝胶对细胞有抑制细胞黏附作用。两组不同载药浓度（1mg/mL和2mg/mL）载药水凝胶在24、48、72、96h这4个时间点细胞增殖抑制率分别为25.8%、21.8%、55.4%、25.6%；44.6%、35.9%、55.5%、31.4%。而1mg/mLPFD溶液在24、48、72、96h这4个时间点细胞增殖抑制率分别为28.9%、29.7%，7.8%、7.7%。【结论】PPP水凝胶具备良好药物缓释性能，载吡非尼酮水凝胶能明显抑制HTF增殖且较含等量药物溶液长效。

目前关于钢管混凝土的耐火研究还主要集中在实心构件上,空心钢管混凝土的相关研究则不足。而实心钢管混凝土可以看作是空心钢管混凝土的特例,因此,很有必要将实心和空心钢管混凝土统一在一起进行研究。采用理论和有限元计算相结合的方法,对钢管混凝土构件在标准火灾下的承载力进行了研究。最终,给出了实、空心钢管混凝土构件在标准火灾下任意时刻的承载力计算公式和保护层厚度的计算方法。

目前,空心钢管混凝土结构被大量应用和推广,但对其抗震性能的研究却比较少,制约了其在实际工程中的进一步应用。对空心普通和再生钢管混凝土柱的抗震性能进行了试验与有限元研究,首先介绍了3根空心圆钢管混凝土柱在定轴力和水平反复荷载作用下的滞回性能试验,分析了不同混凝土和空心率对试件耗能能力及位移延性等抗震性能的影响,研究表明再生混凝土构件的抗震性能要差于相应普通混凝土,而空心率越大,构件的延性和耗能能力越小。其次,采用有限元软件ABAQUS对空心钢管混凝土压弯构件的荷载-位移骨架曲线进行了大量数值计算,分析了各参数对构件骨架曲线及延性的影响。

基于前文对空心普通和再生钢管混凝土柱抗震性能的试验和有限元分析,对空心普通和再生钢管混凝土压弯构件的抗震性能进行了理论研究。首先,运用瑞利-利兹法和极限平衡理论等方法对压弯构件在单调荷载作用下的荷载-位移曲线进行了全过程分析。结合有限元参数分析结果,提出了空心普通和再生钢管混凝土压弯构件骨架曲线理论模型和位移延性系数简化计算公式,可为空心钢管混凝土结构工程实践和相关规程的修订提供理论参考。

结构在遭受意外荷载作用下的抗倒塌能力是目前工程师比较关心的问题,而柱子作为重要的受力构件,其安全性将直接关系到整个结构的安全,汽车撞击是一种常见的意外作用,研究柱构件在汽车撞击作用下的耐撞性具有一定的实际意义。本文首先采用有限元方法对实心和空心钢管混凝土构件在侧向落锤冲击作用下的试验进行模拟及验证。在此基础上,针对实心和空心钢管混凝土柱在汽车撞击作用下的响应做了全程的仿真计算,并对冲击力的特点及构件的破坏情况进行了分析,得出了汽车撞击荷载及构件的耐撞性随着空心率变化的规律,并给出汽车冲击力的计算方法。

目前关于钢管混凝土轴压承载力的计算理论和方法很多,其中分别有针对实心或空心截面、圆形或方形及多边形的。按"统一理论"的思想,不论截面是实心或空心,圆形或多边形,它们的性质应该是统一且连续的,那么计算公式也应该是完全统一且连续的,而现有的计算方法多针对其中部分截面形式或有不连续的情况。基于此推论,本文在基于厚壁圆筒理论建立的圆形实空心钢管混凝土承载力统一计算公式的基础上,将其进一步扩展到多边形截面上,最终得到可以同时适用于实心和空心,圆形和多边形的轴压承载力统一计算公式。

本文为了得到火灾中不同材料结构的整体耐火性能,分别研究了钢管混凝土和纯钢材两种整体结构。对于钢管混凝土框架结构,分析了其在火灾条件下的整体耐火性能、钢管混凝土构件在实际边界约束条件下及不同受火面对其耐火性能的影响,在此基础上对今后结构体系的防火性能设计提出了意见和建议。对于轻钢整体结构,则以雅致公司提供的三种集成房屋为依据,用有限元理论分析了四种荷载组合情况下,集成房屋在火荷载情况下的承载力与变形,得到集成房屋的使用耐火极限和破坏情况,提出了改进办法和设计建议。并在四川国家防火建筑材料质量监督检测中心进行的岩棉夹心板耐火试验基础上,应用有限元理论分析了岩棉彩钢夹心板耐火性能,并研究了不同耐火性能板材的岩棉夹心板和EPS夹心板的框架结构在实际应用中的整体耐火性能。

【目的】初步评价眼内窥镜下激光睫状体光凝术(endoscopic cyclophotocoagulation，ECP)在治疗人工晶体植入术后继发青光眼中的疗效。【方法】采用Endo Optiks，URAM E2激光内窥镜系统对21例21眼人工晶体植入术后继发青光眼进行了ECP治疗，观察术后眼压变化、视力以及并发症情况，术后分别随访了6～26个月，平均18.7个月。【结果】21只眼术前眼压平均(5.08±1.69)kPa，术后平均眼压(1.96±1.23)kPa，术前、术后眼压差异有统计学意义(P＜0.001)。术前平均使用降眼压药物3.3种，术后下降到0.6种，差异有统计学意义(P＜0.001)。术后无需应用药物治疗而眼压≤2.8 kPa者占71.4％，需要应用局部药物治疗控制眼压≤2.8 kPa者占14.3％。患者术后视力较术前有增高(P＜0.05)。21只眼中有1只眼术后出现前房积血，有19只眼术后瞳孔区出现纤维素样渗出，1只眼术后发生渗出性脉络膜脱离。这些并发症出现在早期，井在1周内愈合。所有患者术后均未出现视网膜脱离、眼压过低、眼内炎、交感性眼炎等并发症。【结论】ECP能有效地降低人工晶体植入术后继发青光眼的眼压，无严重并发症。ECP是一种治疗人工晶体植人术后继发青光眼的安全有效的方法。

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Copyright of Asian Journals of Ecotoxicology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To understand the willingness to use pre - exposure prophylaxis (PrEP) among MSM in Guiyang, explore related factors, so as to provide reference for promoting PrEP in Guiyang and Guizhou Province, Methods Two social organizations in Guiyang were recruited among MSM from gay bars, WeChat groups and other social venues and the Internet by convenient sampling method from April to June, 2022. Questionnaires were collected using the a Wen Juan Xing" platform, the contents of the survey included demographic information, behavioral characteristics, knowledge of PrEP, the willingness to use PrEP and so on. Univariate analysis of the willingness to use PrEP was used Chi - square test, logistics regression was carried out to analyze the multiple - factors related to the willingness to use PrEP. Taking the willingness to use PrEP as the dependent variable, univariate and multivariate logistics regression was carried out to analyze the factors related to the willingness to use PrEP. Results 608 valid questionnaires were collected. A total of 146 people (24.0%) knew about PrEP, 216 people (35. 5%) had used PrEP before, and 525 people (86. 3%) were willing to use PrEP if they had high - risk behaviors. The results of multivariate analysis showed that non - Guiyang resident (OR = 3. 09, 95% Cf: 1.42 - 6. 73), living in Guiyang for 7 - 12 months (OR = 5. 12, 95% CI2 25 - 11. 65) and more than 1 year (OR = 4. 19, 95% CI: 1, 85 - 9. 49), employed (OR = 17. 05, 95% CI: 4, 14 - 70. 26), unemployed (OR =6. 29, 95% C/: L 18 - 33. 59), tested for HIV in the last 1 year (OR = 3. 77, 95% Cl: 1. 70 - 8. 38), those who had previously used PrEP (OR = 15. 85, 95% CI: 5. 12 - 49. 11) and aware of PrEP (OR = 4. 82, 95% CI: 1.88 - 12.38) were more likely to use PrEP. Conclusion The MSM population surveyed in Guiyang has a low awareness rate of PrEP, higher willingness to use PrEP, and relative factors, develop targeted measures to promote knowledge about PrEP according to relative factors, so as to improve the knowledge of PrEP, confidence and willingness to use PrEP. Promote the use of PrEP in the context of comprehensive AIDS prevention and control, such as the use of condoms, to reduce the risk of HIV infection. [ABSTRACT FROM AUTHOR]

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the enhancing effect of zinc pretreatment on antidepressant effect of imipramine and to explore the underlying mechanism. Methods SD rats were randomly divided into the model group, zinc group, imipramine group, zinc + imipramine group, zinc + H89 + imipramine group, and control group. In the model group, zinc group, imipramine group, zinc + imipramine group, zinc + H89 + imipramine group, we constructed the learned helplessness depression models by using the electric box； the rats in the control group were also placed in the electric box, but no electric shock was given. After modeling, rats in the model group were intraperitoneally injected with normal saline； rats in the zinc group were intraperitoneally injected with zinc gluconate for 3 consecutive days； rats in the imipramine group were intraperitoneally injected with imipramine as a single dose； rats in the zinc + imipramine group were intraperitoneally injected with zinc gluconate for 3 consecutive days and were given imipramine on the 4th day； rats in the zinc + H89 + imipramine group were intraperitoneally injected with zinc gluconate for 3 consecutive days, and were injected with H89［ protein kinase A ( PKA） inhibitor］ injection after zinc administration on the first day and were given imipramine on the 4th day； rats in the normal control group were injected with normal saline. Depressive behaviors were assessed 24 h after the last administration using the shock shuttle-escape test and forced swimming test. Subsequently, the lateral habenular (LHb） was collected to evaluate the expression of cytochrome oxidase and Kir4. 1 protein in astrocytes. Results In the forced swimming test, the zinc group, imipramine group, zinc + H89 + imipramine group, and LH model group exhibited significantly longer immobility time compared with the control group. Similarly, in the shock shuttle-escape test, these groups showed more failure escape time compared with the control group. Notably, the zinc + imipramine group displayed significantly shorter immobility time and fewer failures in both tests compared with the model group, zinc group, imipramine group and zinc + H89 + imipramine group (all P<0. 01). The expression levels of cytochrome oxidase and Kir4. 1 in the zinc group, imipramine group, zinc + H89 + imipramine group, and model group were higher than those of the control group, the expression levels of cytochrome oxidase and Kir4. 1 in the zinc group, imipramine group, zinc + imipramine group were lower than those of the model group, and the zinc + imipramine group exhibited significantly lower expression levels of cytochrome oxidase and Kir4. 1 in comparison with those of the zinc group and imipramine group (all P<0. 01). Conclusion Zinc pretreatment can rapidly enhance the antidepressant effects of imipramine. Its mechanism of action may be related to regulating the expression of Kir4. 1 and inhibiting the clustered discharge of the LHb, and this effect can be blocked by the PKA inhibitor H89. [ABSTRACT FROM AUTHOR]

This paper summarized the emergency management of asphyxia caused by choking on food in a patient with Parkinson's disease and stroke. Key points of emergency care were emergency triage and green channel management; initiating and executing emergency procedures for asphyxia caused by choking on food, removing obstruction in the airway; conducting the dynamic evaluation, systematic nursing plan and rapid recovery protocol for the patient. (本文总结了1例帕金森病合并脑梗死的老年患者突发噎食窒息的抢救及护理措施, 包括给予精神科急诊分诊, 快速开通绿色通道; 启动精神科门急诊噎食抢救流程, 解除患者呼吸道梗阻; 实施动态的护理评估方法及系统护理方案, 促进患者快速康复。)

一、前言 在生理科学研究和临床中,为了提取尽可能多的生物医学信息,利用通用微型计算机处理生物医学数据,灵活性大,适应性广。本文介绍一种APPLEⅡPLUS微型计算机生物医学数据处理系统,同时给出了此系统正弦波、方波及实际的脑电信号数字处理的一些结果。

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Objective To explore the clinical efficacy and safety of secukinnmab in the treatment of childhood generalized pustular psoriasis (GPP) in order to provide a new therapeutic strategy for childhood generalized pustular psoriasis・ Methods A retrospective analysis was conducted on the clinical data of 25 children w让h GPP treated w让h subcutaneous secukinnmab in our department from June 2020 to June 2022・ The efficacy was evaluated according to Generalized Pustular Psoriasis Physician Global Assessment (GPPGA) scores, Generalized Pustular Psoriasis Area and Severity Index (GPPASI) scores, Children's Dermatology Life Quality Index (CDLQI) scores, and Depression Self-rating Scale for children (DSRSC) scores・ The adverse reactions were also assessed・ Results Following secukinumab treatments, the average time of lesion clearance was 3・ 36 ±0. 99 days・ Alleviations of scales and pustules were observed in majority of patients after 2-week treatment. After 28-week treatment, GPPGA score was reduced from 3・ 56 ± 0. 50 at baseline to 0. 20 ± 0. 50, while GPPASI score was decreased from 34. 83 ± 9・ 24 at baseline to 0. 68 ± 1. 64. Similarly, both CDLQI and DSRSC scores were decreased 14. 96 ± 4. 88 to 0. 40 ± 0. 64 and 11. 41 ±2. 54 to 6・ 64 ± 1・ 80, respectively ・ During the course of treatment, upper respiratory tract infections and eczema were observed in 2 cases each・ One case each had pain with pruritus on the injection s让e and headache・ No other adverse events were observed・ Conclusions Secuki-numab is safe and can rapidly improve the erythema, scales and pustules in pediatric generalized pustular psoriasis in addition to the improvements in patients' quality of life and mental health. [ABSTRACT FROM AUTHOR]

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The ocean is a strategic place to safeguard national sovereignty, security and development interests. China’s maritime diplomacy in the new era has rich policy connotations: the overarching goal of building a maritime community with a shared future; the fundamental task of safeguarding national sovereignty, security and development interests; the basic principle of peace, development, and win-win cooperation; and the strong guarantee of CPC leadership. China’s maritime diplomacy in the new era is a response to the world’s profound changes unseen in a century, and serves the historic mission of building China into a maritime power and the great rejuvenation of the Chinese nation. It is an innovative development of China’s major-country diplomacy in the maritime field. The ideas, concepts, and policies of China’s maritime diplomacy in the new era provide the fundamental guidance for China’s foreign-related work in the maritime domain, and point out the direction for peaceful settlement of disputes, management of crises and risks, deepening dialogue and cooperation, and leading global governance. [ABSTRACT FROM AUTHOR]

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In 2022, the National Cancer Center released the latest data. The results show that the incidence of gynecologic tumors in China shows an upward trend. Taking ovarian cancer as an example, the annual number of new cases is 57 200, with a crude incidence rate of 8.47/100 000, and the annual number of death cases is 27 200, with a crude mortality rate of 4.04/100 000, and the morbidity and mortality are higher than the world standard rates (5.59/100 000 and 2.45/100 000, respectively). Physicians practicing gynecologic oncology in China face greater challenges. Patients with early gynecologic tumors have better overall outcomes after standardized treatment. However, limited treatment modalities and high recurrence rates often lead to poorer prognosis for patients with advanced, recurrent or metastatic gynecologic malignancies. In recent years, emerging treatments such as targeted therapy, immunotherapy and antibody-drug conjugate have ushered in a new era in the treatment of gynecologic tumors, bringing more hope to patients. This article summarized the significant advances in gynecological tumor surgery, radiotherapy, chemotherapy, targeted therapy, immunotherapy and biomarkers in the past year, so as to better guide the individualized and precise treatment of gynecologic tumors. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Combined with the expression profile of long non-coding RNA (IncRNA) and somatic mutation profile in the genome of cervical cancer in TCGA database, a computational framework based on mutation hypothesis was established. A total of 36 IncRNAs associated with genomic instability of cervical cancer were identified, and the function of their co-expressed genes was analyzed. The genes co-expressed with 36 IncRNAs were enriched in the 2-oxy-glutarate and 2-oxy-carboxylic acid metabolic pathways. Gene signatures (GILncSig) of two IncRNAs derived from genomic instability were determined, and the Train group was divided into a high-risk group and a low-risk group. The survival rates of the two groups were significantly different, which was further validated in the Test cohort. According to independent prognostic analysis, GILncSig was an independent prognostic factor associated with overall survival of cervical cancer patients. In conclusion, this study provides key methods and resources to further investigate the role of IncRNA in genomic instability, and provides a potential new pathway for identifying cancer biomarkers associated with genomic instability. [ABSTRACT FROM AUTHOR]

Copyright of Engineering Mechanics / Gongcheng Lixue is the property of Engineering Mechanics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Journal of Oral & Maxillofacial Surgery is the property of Shanghai Jiao Tong University, College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective　To study the effect of repairing patellar cartilage fracture with the suture anchor. Methods　Between July 2016 and June 2018，50 patients with patellar cartilage fracture were chosen，18 male and 32 female，age 17 to 28. All of them were acute lateral dislocation of patella with fracture of patellar cartilage caused by trauma. Lysholm score is （63.8±7.2），VAS score is （ 8±1.7）. All of the patellar cartilage fracture was repaired by suture anchor. Results　All patients’wound healed well after operation，no swelling and effusion of knee joint，patellar cartilage healed well，no loosening of anchor，no displacement of cartilage fragments. Except for 3 patients with mild atrophy of quadriceps and poor recovery of muscle strength at 6 weeks after operation，the other patients’muscle strength recovered well. Lysholm score is （87.3±4.1），VAS score is （ 2±2.3），which were significantly improved compared with those before operation. Conclusion　The operation technique which is fixation of patellar cartilage fracture with suture anchor is simple，can effectively fix cartilage fracture and avoid stimulating anterior patellar bursa，which has its unique advantages. [ABSTRACT FROM AUTHOR]