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237 results on '"Álvarez-Larrán A"'

1. Impact of somatic gene mutations on the risk of thrombosis in myelofibrosis

Author

Pastor-Galán, Irene, Pereira, Arturo, Arellano-Rodrigo, Eduardo, Martín, Iván, Mosquera-Orgueira, Adrián, Gómez-Casares, María-Teresa, Hernández-Sánchez, Alberto, Ferrer-Marín, Francisca, Mora, Elvira, Velez, Patricia, Ayala, Rosa, Angona, Anna, de las Heras, Natalia, Magro, Elena, Mata-Vázquez, María-Isabel, Fox, María-Laura, González de Villambrosía, Sonia, Ramírez, María-José, García, Ana, García-Gutiérrez, Valentín, Cáceres, Amparo, Durán, María-Antonia, Senín, María-Alicia, Raya, José-María, González, José Antonio, Cuevas, Beatriz, Xicoy, Blanca, Garrote, Marta, Ferrer, Blanca, Pérez-Encinas, Manuel, Hernández-Rivas, Jesús María, Bellosillo, Beatriz, Álvarez-Larrán, Alberto, and Hernández-Boluda, Juan Carlos

Published
2024
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2. Integrating AIPSS‐MF and molecular predictors: A comparative analysis of prognostic models for myelofibrosis

Author

Adrián Mosquera‐Orgueira, Eduardo Arellano‐Rodrigo, Marta Garrote, Iván Martín, Manuel Pérez‐Encinas, María‐Teresa Gómez‐Casares, Alberto Hernández‐Sánchez, Francisca Ferrer‐Marín, Elvira Mora, Patricia Velez, Rosa Ayala, Anna Angona, Natalia de las Heras, Elena Magro, Carlos Pérez‐Míguez, Davide Crucitti, María‐Isabel Mata‐Vázquez, María‐Laura Fox, Sonia González de Villambrosía, María‐José Ramírez, Ana García, Valentín García‐Gutiérrez, Amparo Cáceres, María‐Antonia Durán, María‐Alicia Senín, José‐María Raya, José A. González, Beatriz Cuevas, Blanca Xicoy, Jyoti Nangalia, Jesús M. Hernández‐Rivas, Beatriz Bellosillo, Alberto Álvarez‐Larrán, Juan C. Hernández‐Boluda, and Spanish MPN Group (GEMFIN)

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2024
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3. Philadelphia-negative chronic myeloproliferative neoplasm follow-up: when the phone rings. Changes during the COVID-19 pandemic and patient satisfaction. Experience in 30 health centers in Spain

Author

Ortuzar, Ariana, Fox, María Laura, Vera, Juan Antonio, Lorenzo Vizcaya, Álvaro, Marín Sánchez, Alberto, Llopis Calatayud, Inmaculada, Carbonell, Sara, Álvarez-Larrán, Alberto, Mata Serna, Raquel, Marco Buades, Josefa E., Quiroz Cervantes, Keina, Martínez Hellín, Ángela, Blum Domínguez, Alejandra, Caballero Navarro, Gonzalo, Cáceres Sansaloni, Amparo, Guerrero Fernández, Lucía, Muñoz Linares, Cristina, Gasior Kabat, Mercedes, Pérez López, Raúl, Fernández Rodríguez, Ángeles, Martínez Bilbao, Cristina, Cobo Rodríguez, María Teresa, Díaz, Álvaro, Durán, M. Antonia, Santaliestra Tomas, Marta, García-Gutierrez, Valentín, Magro Mazo, Elena, Hernández-Boluda, Juan Carlos, Segura, Adrián, Raya, José María, Navas Elorza, Begoña, and Osorio, Santiago

Published
2023
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4. CNL and aCML should be considered as a single entity based on molecular profiles and outcomes

Author

Carreño-Tarragona, Gonzalo, Álvarez-Larrán, Alberto, Harrison, Claire, Martínez-Ávila, José Carlos, Hernández-Boluda, Juan Carlos, Ferrer-Marín, Francisca, Radia, Deepti H., Mora, Elvira, Francis, Sebastian, González-Martínez, Teresa, Goddard, Kathryn, Pérez-Encinas, Manuel, Narayanan, Srinivasan, Raya, José María, Singh, Vikram, Gutiérrez, Xabier, Toth, Peter, Amat-Martínez, Paula, Mcilwaine, Louisa, Alobaidi, Magda, Mayani, Karan, McGregor, Andrew, Stuckey, Ruth, Psaila, Bethan, Segura, Adrián, Alvares, Caroline, Davidson, Kerri, Osorio, Santiago, Cutting, Robert, Sweeney, Caroline P., Rufián, Laura, Moreno, Laura, Cuenca, Isabel, Smith, Jeffery, Morales, María Luz, Gil-Manso, Rodrigo, Koutsavlis, Ioannis, Wang, Lihui, Mead, Adam J., Rozman, María, Martínez-López, Joaquín, Ayala, Rosa, and Cross, Nicholas C. P.

Published
2023
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5. Low-risk polycythemia vera treated with phlebotomies: clinical characteristics, hematologic control and complications in 453 patients from the Spanish Registry of Polycythemia Vera

Author

Triguero, Ana, Pedraza, Alexandra, Pérez-Encinas, Manuel, Mata-Vázquez, María Isabel, Vélez, Patricia, Fox, Laura, Gómez-Calafat, Montse, García-Delgado, Regina, Gasior, Mercedes, Ferrer-Marín, Francisca, García-Gutiérrez, Valentín, Angona, Anna, Gómez-Casares, María Teresa, Cuevas, Beatriz, Martínez, Clara, Pérez, Raúl, Raya, José María, Guerrero, Lucía, Murillo, Ilda, Bellosillo, Beatriz, Hernández-Boluda, Juan Carlos, Sanz, Cristina, and Álvarez-Larrán, Alberto

Published
2022
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6. Appropriate management of polycythaemia vera with cytoreductive drug therapy: European LeukemiaNet 2021 recommendations

Author

Marchetti, Monia, Vannucchi, Alessandro Maria, Griesshammer, Martin, Harrison, Claire, Koschmieder, Steffen, Gisslinger, Heinz, Álvarez-Larrán, Alberto, De Stefano, Valerio, Guglielmelli, Paola, Palandri, Francesca, Passamonti, Francesco, Barosi, Giovanni, Silver, Richard T, Hehlmann, Rüdiger, Kiladjian, Jean-Jacques, and Barbui, Tiziano

Published
2022
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7. Managing hematological cancer patients during the COVID-19 pandemic: an ESMO-EHA Interdisciplinary Expert Consensus

Author

Buske, C., Dreyling, M., Alvarez-Larrán, A., Apperley, J., Arcaini, L., Besson, C., Bullinger, L., Corradini, P., Giovanni Della Porta, M., Dimopoulos, M., D’Sa, S., Eich, H.T., Foà, R., Ghia, P., da Silva, M.G., Gribben, J., Hajek, R., Harrison, C., Heuser, M., Kiesewetter, B., Kiladjian, J.J., Kröger, N., Moreau, P., Passweg, J.R., Peyvandi, F., Rea, D., Ribera, J.-M., Robak, T., San-Miguel, J.F., Santini, V., Sanz, G., Sonneveld, P., von Lilienfeld-Toal, M., Wendtner, C., Pentheroudakis, G., and Passamonti, F.

Published
2022
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8. Machine Learning Improves Risk Stratification in Myelofibrosis: An Analysis of the Spanish Registry of Myelofibrosis

Author

Adrián Mosquera-Orgueira, Manuel Pérez-Encinas, Alberto Hernández-Sánchez, Teresa González-Martínez, Eduardo Arellano-Rodrigo, Javier Martínez-Elicegui, Ángela Villaverde-Ramiro, José-María Raya, Rosa Ayala, Francisca Ferrer-Marín, María-Laura Fox, Patricia Velez, Elvira Mora, Blanca Xicoy, María-Isabel Mata-Vázquez, María García-Fortes, Anna Angona, Beatriz Cuevas, María-Alicia Senín, Angel Ramírez-Payer, María-José Ramírez, Raúl Pérez-López, Sonia González de Villambrosía, Clara Martínez-Valverde, María-Teresa Gómez-Casares, Carmen García-Hernández, Mercedes Gasior, Beatriz Bellosillo, Juan-Luis Steegmann, Alberto Álvarez-Larrán, Jesús María Hernández-Rivas, Juan Carlos Hernández-Boluda, and on behalf of the Spanish MPN Group (GEMFIN).

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Myelofibrosis (MF) is a myeloproliferative neoplasm (MPN) with heterogeneous clinical course. Allogeneic hematopoietic cell transplantation remains the only curative therapy, but its morbidity and mortality require careful candidate selection. Therefore, accurate disease risk prognostication is critical for treatment decision-making. We obtained registry data from patients diagnosed with MF in 60 Spanish institutions (N = 1386). These were randomly divided into a training set (80%) and a test set (20%). A machine learning (ML) technique (random forest) was used to model overall survival (OS) and leukemia-free survival (LFS) in the training set, and the results were validated in the test set. We derived the AIPSS-MF (Artificial Intelligence Prognostic Scoring System for Myelofibrosis) model, which was based on 8 clinical variables at diagnosis and achieved high accuracy in predicting OS (training set c-index, 0.750; test set c-index, 0.744) and LFS (training set c-index, 0.697; test set c-index, 0.703). No improvement was obtained with the inclusion of MPN driver mutations in the model. We were unable to adequately assess the potential benefit of including adverse cytogenetics or high-risk mutations due to the lack of these data in many patients. AIPSS-MF was superior to the IPSS regardless of MF subtype and age range and outperformed the MYSEC-PM in patients with secondary MF. In conclusion, we have developed a prediction model based exclusively on clinical variables that provides individualized prognostic estimates in patients with primary and secondary MF. The use of AIPSS-MF in combination with predictive models that incorporate genetic information may improve disease risk stratification.

Published
2023
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10. Predicting Survival after Allogeneic Hematopoietic Cell Transplantation in Myelofibrosis: Performance of the Myelofibrosis Transplant Scoring System (MTSS) and Development of a New Prognostic Model

Author

Hernández-Boluda, Juan-Carlos, Pereira, Arturo, Alvarez-Larran, Alberto, Martín, Ana-Africa, Benzaquen, Ana, Aguirre, Lourdes, Mora, Elvira, González, Pedro, Mora, Jorge, Dorado, Nieves, Sampol, Antonia, García-Gutiérrez, Valentín, López-Godino, Oriana, Fox, María-Laura, Reguera, Juan Luis, Pérez-Encinas, Manuel, Pascual, María-Jesús, Xicoy, Blanca, Parody, Rocío, González-Pinedo, Leslie, Español, Ignacio, Avendaño, Alejandro, Correa, Juan-Gonzalo, Vallejo, Carlos, Jurado, Manuel, García-Cadenas, Irene, Osorio, Santiago, Durán, María-Antonia, Sánchez-Guijo, Fermín, Cervantes, Francisco, and Piñana, José-Luis

Published
2020
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11. DNMT3A/TET2/ASXL1 Mutations are an Age-independent Thrombotic Risk Factor in Polycythemia Vera Patients: An Observational Study.

Author

Segura-Díaz, Adrián, Stuckey, Ruth, Florido, Yanira, Sobas, Marta, Álvarez-Larrán, Alberto, Ferrer-Marín, Francisca, Pérez-Encinas, Manuel, Carreño-Tarragona, Gonzalo, Fox, María L., Tazón Vega, Barbara, Cuevas, Beatriz, López Rodríguez, Juan F., Sánchez-Farías, Nuria, González-Martín, Jesús M., Gómez-Casares, María T., and Bilbao-Sieyro, Cristina

Published
2024
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12. Development and validation of a sequential two-step algorithm for the screening of individuals with potential polycythaemia vera

Author

Miguel Piris-Villaespesa, Alberto Álvarez-Larrán, Adolfo Saez-Marín, Claudia Nuñez-Torrón, Gloria Muñoz-Martin, Ricardo Sánchez, Francisco J. del Castillo, Jesús Villarrubia, Javier Lopez-Jimenez, Joaquin Martinez-Lopez, and Valentin Garcia-Gutierrez

Subjects
Medicine, Science
Abstract

Abstract In 2016, the WHO included haemoglobin values within normal ranges as a diagnostic criterion for Polycythaemia Vera (PV). Since then, concerns have arisen that a large number of patients are undergoing unnecessary screening for PV. To address this issue, we estimated the prevalence of JAK2 p.V617F in individuals with elevated haemoglobin or haematocrit and developed and validated a screening algorithm for PV. A total of 15,366 blood counts performed in seven non-consecutive days were reviewed, of which 1001 were selected for subsequent JAK2 p.V617F mutation screening. Eight (0.8%) new JAK2 p.V617F-mutated cases were detected. From ROC curves, a two-step algorithm was developed based on the optimal cut-off for the detection of the JAK2 p.V617F mutation. The algorithm was prospectively validated in an independent cohort of 15,298 blood counts. A total of 1595 (10.4%) cases met the criterion for haemoglobin or haematocrit, of whom 581 passed to step 2 (3.8% of the total). The JAK2 p.V617F mutation was detected in 7 of the 501 patients tested, which accounts for 0.04% of the total cohort and 0.4% of patients with erythrocytosis. In conclusion, this data show that our two-step algorithm improves the selection of candidates for JAK2 p.V617F testing.

Published
2021
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15. P1032: REAL-LIFE VALIDATION OF MIPSS70: A RETROSPECTIVE MULTICENTER AND NGS ANALYSIS FROM THE GEMFIN DATABASE

Author

A. Hernández-Sánchez, Á. Villaverde-Ramiro, A. Álvarez-Larrán, E. Arellano-Rodrigo, M. Pérez Encinas, F. Ferrer Marín, E. Such, G. Carreño Gómez-Tarragona, N. de las Heras Rodríguez, M. A. Durán Pastor, M. I. Mata Vázquez, L. Fox, J. M. Raya Sánchez, E. Magro Mazo, M. T. Gómez Casares, M. J. Ramírez Sánchez, B. Xicoy Cirici, Á. Ramírez Páyer, M. J. Fernández Llavador, A. Á. Martín López, A. Mosquera Orgueira, J. Martínez Elicegui, M. Garrote, B. Bellosillo, T. González, J. Hernández-Rivas, and J. C. Hernández Boluda

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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16. A novel ETV6::FGFR1 fusion gene in a myeloid/lymphoid neoplasm with FGFR1 rearrangement sensitive to specific FGFR1-2-3 inhibition.

Author

Jiménez-Vicente, Carlos, Garrote, Marta, López-Guerra, Mónica, Villamón, Eva, Guijarro, Francesca, Perez-Valencia, Amanda Isabel, Martinez-Roca, Alexandra, Balaguer, Olga, Álvarez-Larrán, Alberto, Hernández-Boluda, Juan Carlos, Rovira, Montserrat, Colomer, Dolors, Diaz-Beyá, Marina, Rozman, Maria, and Esteve, Jordi

Subjects
GENE fusion, TOXIC epidermal necrolysis, TUMORS, FIBROBLAST growth factor receptors, BLAST injuries, GENETIC testing, DNA analysis
Abstract

This article discusses a rare case of a myeloid/lymphoid neoplasm with FGFR1 rearrangement, specifically the ETV6::FGFR1 fusion gene. The patient initially presented with T-lymphoblastic lymphoma and was treated with chemotherapy, but later relapsed with a mixed phenotype of T-lymphoblastic lymphoma and acute myeloid leukemia. The patient was refractory to various salvage chemotherapy regimens but showed a response to treatment with pemigatinib, a specific FGFR1-2-3 inhibitor. The patient underwent allogeneic hematopoietic stem cell transplantation and maintained a complete response. This case highlights the importance of genetic screening and targeted therapies in the management of myeloid/lymphoid neoplasms with FGFR1 rearrangement. [Extracted from the article]

Published
2024
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17. DNMT3A/TET2/ASXL1 mutations are an age-independent thrombotic risk factor in polycythemia vera patients: an observational study

Author

Segura-Díaz, Adrián, primary, Stuckey, Ruth, additional, Florido, Yanira, additional, Sobas, Marta, additional, Álvarez-Larrán, Alberto, additional, Ferrer-Marín, Francisca, additional, Pérez-Encinas, Manuel, additional, Carreño-Tarragona, Gonzalo, additional, Fox, María Laura, additional, Vega, Barbara Tazón, additional, Cuevas, Beatriz, additional, Rodríguez, Juan Francisco López, additional, Farías-Sánchez, Nuria, additional, González-Martín, Jesús M., additional, Gómez-Casares, María Teresa, additional, and Bilbao-Sieyro, Cristina, additional

Published
2023
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19. Clinical Characteristics and Outcomes of Patients with Primary and Secondary Myelofibrosis According to the Genomic Classification Using Targeted Next-Generation Sequencing

Author

Garrote, Marta, primary, López-Guerra, Mónica, additional, Arellano-Rodrigo, Eduardo, additional, Rozman, María, additional, Carbonell, Sara, additional, Guijarro, Francesca, additional, Santaliestra, Marta, additional, Triguero, Ana, additional, Colomer, Dolors, additional, Cervantes, Francisco, additional, and Álvarez-Larrán, Alberto, additional

Published
2023
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20. Cytogenetic Assessment and Risk Stratification in Myelofibrosis with Optical Genome Mapping

Author

Díaz-González, Álvaro, primary, Mora, Elvira, additional, Avetisyan, Gayane, additional, Furió, Santiago, additional, De la Puerta, Rosalía, additional, Gil, José Vicente, additional, Liquori, Alessandro, additional, Villamón, Eva, additional, García-Hernández, Carmen, additional, Santiago, Marta, additional, García-Ruiz, Cristian, additional, Llop, Marta, additional, Ferrer-Lores, Blanca, additional, Barragán, Eva, additional, García-Palomares, Silvia, additional, Mayordomo, Empar, additional, Luna, Irene, additional, Vicente, Ana, additional, Cordón, Lourdes, additional, Senent, Leonor, additional, Álvarez-Larrán, Alberto, additional, Cervera, José, additional, De la Rubia, Javier, additional, Hernández-Boluda, Juan Carlos, additional, and Such, Esperanza, additional

Published
2023
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21. Cytogenetic Assessment and Risk Stratification in Myelofibrosis with Optical Genome Mapping

Author

Such, Álvaro Díaz-González, Elvira Mora, Gayane Avetisyan, Santiago Furió, Rosalía De la Puerta, José Vicente Gil, Alessandro Liquori, Eva Villamón, Carmen García-Hernández, Marta Santiago, Cristian García-Ruiz, Marta Llop, Blanca Ferrer-Lores, Eva Barragán, Silvia García-Palomares, Empar Mayordomo, Irene Luna, Ana Vicente, Lourdes Cordón, Leonor Senent, Alberto Álvarez-Larrán, José Cervera, Javier De la Rubia, Juan Carlos Hernández-Boluda, and Esperanza

Subjects
myelofibrosis, optical genome mapping, chromosome banding analysis, prognosis
Abstract

Cytogenetic assessment in myelofibrosis is essential for risk stratification and patient management. However, an informative karyotype is unavailable in a significant proportion of patients. Optical genome mapping (OGM) is a promising technique that allows for a high-resolution assessment of chromosomal aberrations (structural variants, copy number variants, and loss of heterozygosity) in a single workflow. In this study, peripheral blood samples from a series of 21 myelofibrosis patients were analyzed via OGM. We assessed the clinical impact of the application of OGM for disease risk stratification using the DIPSS-plus, GIPSS, and MIPSS70+v2 prognostic scores compared with the standard-of-care approach. OGM, in combination with NGS, allowed for risk classification in all cases, compared to only 52% when conventional techniques were used. Cases with unsuccessful karyotypes (n = 10) using conventional techniques were fully characterized using OGM. In total, 19 additional cryptic aberrations were identified in 9 out of 21 patients (43%). No alterations were found via OGM in 4/21 patients with previously normal karyotypes. OGM upgraded the risk category for three patients with available karyotypes. This is the first study using OGM in myelofibrosis. Our data support that OGM is a valuable tool that can greatly contribute to improve disease risk stratification in myelofibrosis patients.

Published
2023
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28. Machine Learning Improves Risk Stratification in Myelofibrosis: An Analysis of the Spanish Registry of Myelofibrosis

Author

Mosquera Orgueira, Adrián, Pérez Encinas, Manuel, Hernández Sánchez, Alberto, González Martínez, Teresa, Arellano Rodrigo, Eduardo, Martínez Elicegui, Javier, Villaverde Ramiro, Ángela, Raya, José María, Ayala, Rosa, Ferrer Marín, Francisca, Fox, María Laura, Velez, Patricia, Mora, Elvira, Xicoy, Blanca, Mata Vázquez, María Isabel, García Fortes, María, Angona, Anna, Cuevas, Beatriz, Senín, María Alicia, Ramírez Payer, Angel, Ramírez, María José, Pérez López, Raúl, González de Villambrosía, Sonia, Martínez Valverde, Clara, Gómez Casares, María Teresa, García Hernández, Carmen, Gasior, Mercedes, Bellosillo Paricio, Beatriz, Steegmann, Juan Luis, Álvarez Larrán, Alberto, Hernández Rivas, Jesús María, Hernández Boluda, Juan Carlos, The Spanish MPN Group (GEMFIN)., Institut Català de la Salut, [Mosquera-Orgueira A, Pérez-Encinas M] Hospital Clínico Universitario, Santiago de Compostela, Spain. [Hernández-Sánchez A, González-Martínez T, Martínez-Elicegui J] Hospital Clínico, Salamanca, Spain. [Arellano-Rodrigo E] Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. [Fox ML] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Intel·ligència artificial - Aplicacions a la medicina, Pronòstic mèdic, Mielofibrosi, Immunology, Myelofibrosis, Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myeloid, Acute [DISEASES], enfermedades hematológicas y linfáticas::enfermedades hematológicas::enfermedades de la médula ósea::trastornos mieloproliferativos [ENFERMEDADES], Cell Biology, Hematology, Prognosis, Biochemistry, Ciencias de la información::metodologías computacionales::algoritmos::inteligencia artificial::aprendizaje automático [CIENCIA DE LA INFORMACIÓN], neoplasias::neoplasias por tipo histológico::leucemia::leucemia mieloide::leucemia mieloide aguda [ENFERMEDADES], Aprenentatge automàtic, Machine learning, Sang - Malalties, Hemic and Lymphatic Diseases::Hematologic Diseases::Bone Marrow Diseases::Myeloproliferative Disorders [DISEASES], Information Science::Computing Methodologies::Algorithms::Artificial Intelligence::Machine Learning [INFORMATION SCIENCE]
Abstract

Aprendizaje automático; Mielofibrosis Aprenentatge automàtic; Mielofibrosi Machine learning; Myelofibrosis Myelofibrosis (MF) is a myeloproliferative neoplasm (MPN) with heterogeneous clinical course. Allogeneic hematopoietic cell transplantation remains the only curative therapy, but its morbidity and mortality require careful candidate selection. Therefore, accurate disease risk prognostication is critical for treatment decision-making. We obtained registry data from patients diagnosed with MF in 60 Spanish institutions (N = 1386). These were randomly divided into a training set (80%) and a test set (20%). A machine learning (ML) technique (random forest) was used to model overall survival (OS) and leukemia-free survival (LFS) in the training set, and the results were validated in the test set. We derived the AIPSS-MF (Artificial Intelligence Prognostic Scoring System for Myelofibrosis) model, which was based on 8 clinical variables at diagnosis and achieved high accuracy in predicting OS (training set c-index, 0.750; test set c-index, 0.744) and LFS (training set c-index, 0.697; test set c-index, 0.703). No improvement was obtained with the inclusion of MPN driver mutations in the model. We were unable to adequately assess the potential benefit of including adverse cytogenetics or high-risk mutations due to the lack of these data in many patients. AIPSS-MF was superior to the IPSS regardless of MF subtype and age range and outperformed the MYSEC-PM in patients with secondary MF. In conclusion, we have developed a prediction model based exclusively on clinical variables that provides individualized prognostic estimates in patients with primary and secondary MF. The use of AIPSS-MF in combination with predictive models that incorporate genetic information may improve disease risk stratification.

Published
2023

30. An analysis of the kinetics of molecular response during the first trimester of treatment with nilotinib in newly diagnosed chronic myeloid leukemia patients in chronic phase

Author

Steegmann, Juan Luis, Colomer, Dolors, Gómez-Casares, Maria-Teresa, García-Gutiérrez, Valentín, Ortí, Guillermo, Ramírez-Payer, Angel, Olavarria, Eduardo, Vall-llovera, Ferrán, Giraldo, Pilar, Conde, Eulogio, Vallansot, Rolando, López-Lorenzo, Jose Luis, Palomera, Luis, Álvarez-Larrán, Alberto, Conesa, Venancio, Bautista, Guiomar, Casas, Laura, Giles, Frank, Hochhaus, Andreas, and Casado-Montero, Luis Felipe

Published
2017
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31. Philadelphia-negative chronic myeloproliferative neoplasm follow-up: when the phone rings. Changes during the COVID-19 pandemic and patient satisfaction. Experience in 30 health centers in Spain

Author

Ariana Ortuzar, María Laura Fox, Juan Antonio Vera, Álvaro Lorenzo Vizcaya, Alberto Marín Sánchez, Inmaculada Llopis Calatayud, Sara Carbonell, Alberto Álvarez-Larrán, Raquel Mata Serna, Josefa E. Marco Buades, Keina Quiroz Cervantes, Ángela Martínez Hellín, Alejandra Blum Domínguez, Gonzalo Caballero Navarro, Amparo Cáceres Sansaloni, Lucía Guerrero Fernández, Cristina Muñoz Linares, Mercedes Gasior Kabat, Raúl Pérez López, Ángeles Fernández Rodríguez, Cristina Martínez Bilbao, María Teresa Cobo Rodríguez, Álvaro Díaz, M. Antonia Durán, Marta Santaliestra Tomas, Valentín García-Gutierrez, Elena Magro Mazo, Juan Carlos Hernández-Boluda, Adrián Segura, José María Raya, Begoña Navas Elorza, and Santiago Osorio

Subjects
Myeloproliferative Disorders, SARS-CoV-2, Follow-up, COVID-19, Patient satisfaction, Hematology, General Medicine, Telemedicine, Spain, Primary Myelofibrosis, Ph-MPN, Humans, Pandemics, Polycythemia Vera, Aged, Retrospective Studies, Thrombocythemia, Essential
Abstract

The SARS-CoV-2 pandemic has favored the expansion of telemedicine. Philadelphia-negative chronic myeloproliferative neoplasms (Ph-MPN) might be good candidates for virtual follow-up. In this study, we aimed to analyze the follow-up of patients with Ph-MPN in Spain during COVID-19, its effectiveness, and acceptance among patients. We present a multicenter retrospective study from 30 centers. Five hundred forty-one patients were included with a median age of 67 years (yr). With a median follow-up of 19 months, 4410 appointments were recorded. The median of visits per patient was 7 and median periodicity was 2.7 months; significantly more visits and a higher frequency of them were registered in myelofibrosis (MF) patients. 60.1% of visits were in-person, 39.5% were by telephone, and 0.3% were videocall visits, with a predominance of telephone visits for essential thrombocythemia (ET) and polycythemia vera (PV) patients over MF, as well as for younger patients ( 50 yr). The proportion of phone visits significantly decreased after the first semester of the pandemic. Pharmacological modifications were performed only in 25.7% of the visits, and, considering overall management, ET patients needed fewer global treatment changes. Telephone contact effectiveness reached 90% and only 5.4% required a complementary in-person appointment. Although 56.2% of the cohort preferred in-person visits, 90.5% of our patients claimed to be satisfied with follow-up during the pandemic, with an 83% of positive comments. In view of our results, telemedicine has proven effective and efficient, and might continue to play a complementary role in Ph-MPN patients' follow-up.

Published
2022

32. Philadelphia-negative chronic myeloproliferative neoplasm follow-up: when the phone rings. Changes during the COVID-19 pandemic and patient satisfaction. Experience in 30 health centers in Spain

Author

Ortuzar, Ariana, primary, Fox, María Laura, additional, Vera, Juan Antonio, additional, Lorenzo Vizcaya, Álvaro, additional, Marín Sánchez, Alberto, additional, Llopis Calatayud, Inmaculada, additional, Carbonell, Sara, additional, Álvarez-Larrán, Alberto, additional, Mata Serna, Raquel, additional, Marco Buades, Josefa E., additional, Quiroz Cervantes, Keina, additional, Martínez Hellín, Ángela, additional, Blum Domínguez, Alejandra, additional, Caballero Navarro, Gonzalo, additional, Cáceres Sansaloni, Amparo, additional, Guerrero Fernández, Lucía, additional, Muñoz Linares, Cristina, additional, Gasior Kabat, Mercedes, additional, Pérez López, Raúl, additional, Fernández Rodríguez, Ángeles, additional, Martínez Bilbao, Cristina, additional, Cobo Rodríguez, María Teresa, additional, Díaz, Álvaro, additional, Durán, M. Antonia, additional, Santaliestra Tomas, Marta, additional, García-Gutierrez, Valentín, additional, Magro Mazo, Elena, additional, Hernández-Boluda, Juan Carlos, additional, Segura, Adrián, additional, Raya, José María, additional, Navas Elorza, Begoña, additional, and Osorio, Santiago, additional

Published
2022
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33. MPN-135 Safety and Efficacy of Pelabresib in Combination With Ruxolitinib for JAK Inhibitor-Naïve Patients With Myelofibrosis: Latest Data From the Phase 3 MANIFEST-2 Study

Author

Mascarenhas, John, Rampal, Raajit K., Grosicki, Sebastian, Chraniuk, Dominik, Abruzzese, Elisabetta, Bose, Prithviraj, Gerds, Aaron, Vannucchi, Alessandro M., Palandri, Francesca, Lee, Sung-Eun, Gupta, Vikas, Lucchesi, Alessandro, Oh, Stephen T., Kuykendall, Andrew T., Patriarca, Andrea, Álvarez-Larrán, Alberto, Mesa, Ruben, Kiladjian, Jean-Jacques, Talpaz, Moshe, Lavie, David, Harris, Morgan, Kays, Sarah-Katharina, Maria Jegg, Anna, Wu, Manlei, Brown, Barbara, and Harrison, Claire

Published
2024
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34. Safety and Efficacy of Pelabresib in Combination With Ruxolitinib for JAK Inhibitor-Naïve Patients With Myelofibrosis: Latest Data From the Phase 3 MANIFEST-2 Study

Author

Mascarenhas, John, Rampal, Raajit K., Grosicki, Sebastian, Chraniuk, Dominik, Abruzzese, Elisabetta, Bose, Prithviraj, Gerds, Aaron, Vannucchi, Alessandro M., Palandri, Francesca, Lee, Sung-Eun, Gupta, Vikas, Lucchesi, Alessandro, Oh, Stephen T., Kuykendall, Andrew T., Patriarca, Andrea, Álvarez-Larrán, Alberto, Mesa, Ruben, Kiladjian, Jean-Jacques, Talpaz, Moshe, Lavie, David, Harris, Morgan, Kays, Sarah-Katharina, Maria Jegg, Anna, Wu, Manlei, Brown, Barbara, and Harrison, Claire

Published
2024
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35. P1032: REAL-LIFE VALIDATION OF MIPSS70: A RETROSPECTIVE MULTICENTER AND NGS ANALYSIS FROM THE GEMFIN DATABASE

Author

Hernández-Sánchez, A., primary, Villaverde-Ramiro, Á., additional, Álvarez-Larrán, A., additional, Arellano-Rodrigo, E., additional, Pérez Encinas, M., additional, Ferrer Marín, F., additional, Such, E., additional, Carreño Gómez-Tarragona, G., additional, de las Heras Rodríguez, N., additional, Durán Pastor, M. A., additional, Mata Vázquez, M. I., additional, Fox, L., additional, Raya Sánchez, J. M., additional, Magro Mazo, E., additional, Gómez Casares, M. T., additional, Ramírez Sánchez, M. J., additional, Xicoy Cirici, B., additional, Ramírez Páyer, Á., additional, Fernández Llavador, M. J., additional, Martín López, A. Á., additional, Mosquera Orgueira, A., additional, Martínez Elicegui, J., additional, Garrote, M., additional, Bellosillo, B., additional, González, T., additional, Hernández-Rivas, J., additional, and Hernández Boluda, J. C., additional

Published
2022
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36. P1001: DNMT3A/TET2/ASXL1 MUTATIONS DETERMINE THROMBOTIC RISK IN POLYCYTHAEMIA VERA

Author

Segura Diaz, A., primary, Stuckey, R., additional, Florido Ortega, Y., additional, Sobas, M., additional, Álvarez Larrán, A., additional, Ferrer-Marín, F., additional, Pérez Encinas, M., additional, Carreño, G., additional, Fox, M., additional, Tazón Vega, B., additional, Cuevas, B., additional, López Rodriguez, J., additional, Farías Sánchez, N., additional, Bilbao Sieyro, C., additional, and Gómez Casares, M., additional

Published
2022
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37. Protection Against Breakthrough Delta/Omicron Variants in Vaccinated Patients with Myeloproliferative Neoplasms (MPN)

Author

Barbui, Tiziano, Carobbio, Alessandra, Ghirardi, Arianna, Iurlo, Alessandra, De Stefano, Valerio, Sobas, Marta Anna, Rumi, Elisa, Elli, Elena Maria, Lunghi, Francesca, Gasior Kabat, Mercedes, Cuevas, Beatriz, Guglielmelli, Paola, Bonifacio, Massimiliano, Marchetti, Monia, Alvarez-Larran, Alberto, Fox, Laura Maria, Bellini, Marta, Daffini, Rosa, Benevolo, Giulia, Carreño, Gonzalo, Patriarca, Andrea, Al-Ali, Haifa Kathrin, Andrade, Marcio, Palandri, Francesca, Harrison, Claire, Foncillas, Maria Angeles, Osorio, Santiago, Koschmieder, Steffen, Magro, Elena, Kiladjian, Jean-Jacques, Bolaños, Estefanía, Heidel, Florian H., Quiroz, Keina, Griesshammer, Martin, García Gutiérrez, Valentín, Marin Sanchez, Alberto, Hernandez Boluda, Juan Carlos, Lopez Abadia, Emma, Carli, Giuseppe, Sagüés, Miguel, Kusec, Rajko, Xicoy, Blanca, Guenova, Margarita, Navas, Begoña, Angona, Anna, Cichocka, Edyta, Masternak, Anna, Cattaneo, Daniele, Bucelli, Cristina, Betti, Silvia, Borsani, Oscar, Cavalca, Fabrizio, Carbonell, Sara, Curto-Garcia, Natalia, Benajiba, Lina, Rambaldi, Alessandro, and Vannucchi, Alessandro M.

Published
2022
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38. Coexisting Myeloproliferative and Lymphoproliferative Neoplasms: A European Multicenter Retrospective Study

Author

Fiallo Suarez, Dolly Viviana Viviana, Stuckey, Ruth, Bilbao, Cristina, Tapia Torres, Maria, Lemes Castellano, Maria Angelina, Fernández-Fuertes, Fernando, Pérez-Ortiz, Leonor, Borsani, Oscar, Rumi, Elisa, Ianotto, Jean-Christophe, Ferrer Marin, Francisca, Gasior Kabat, Mercedes, Cuevas, Beatriz, Lewandowski, Krzysztof, Alvarez-Larran, Alberto, Sobas, Marta Anna, Santoro, Marco, Foncillas, María Ángeles, Drozd-Sokolowska, Joanna, Kandula, Zuzanna, Hernandez Boluda, Juan Carlos, Angona, Anna, Carreño, Gonzalo, Senin, María Alicia, Mata Vazquez, Maria Isabel, Fox, Maria Laura, Del Orbe, Rafael, Velez Tenza, Patricia, Vallansot, Rolando, and Gómez-Casares, María Teresa

Published
2022
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39. Toxicity of Asciminib in Real Clinical Practice; Analysis of Side Effects and Cross-Intolerance with Tyrosine Kinase Inhibitors

Author

Pérez-Lamas, Lucía, Luna, Alejandro, Boque, Concepcion, Senin, María Alicia, Xicoy, Blanca, Giraldo, Pilar, Perez Lopez, Raul, Ruiz Nuño, Concepción, De las Heras, Natalia, Mora Casterá, Elvira, Garcia-Hernandez, Carmen, Segura Diaz, Adrian, Steegmann, Juan Luis, Velez Tenza, Patricia, Sanchez-Guijo, Fermin, Garcia-Noblejas Moya, Ana Maria, Juan Vera Goñi, Juan Antonio, Moreno Vega, Melania, Alvarez-Larran, Alberto, Cortes, Montse, Perez Encinas, Manuel, Serrano, Luis, Angona, Anna, Rosell, Ana, Lakhwani, Sunil, Colorado, Mercedes, Ramila, Elena, Cervero, Carlos, Cuevas, Beatriz, Villalon Blanco, Lucia, Hernandez Boluda, Juan Carlos, Paz Coll, Antonio, Gómez García de Soria, Valle, Fernández, Maria Jose, Casado, Luis Felipe, Alonso-Dominguez, Juan Manuel, Anguita Arance, Maria Magdalena, Carrascosa Mastell, Patricia, Salamanca Cuenca, Araceli, Jiménez-Velasco, Antonio, Ramírez, María José, López Esteban, Miguel, Sierra Pacho, Magdalena, Santaliestra, Marta, Alda Alvarez, Olga, de Paz, Raquel, and García Gutiérrez, Valentín

Published
2022
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40. Risk of Progression in Chronic Phase-Chronic Myeloid Leukemia (CML) Patients Eligible for Tyrosine Kinase Inhibitor Discontinuation: The Tfr-PRO Study

Author

Zambrotta, Giovanni, Assouline, Sarit, Nicolini, Franck E., Abruzzese, Elisabetta, Miggiano, Maria Cristina, Elena, Chiara, Alvarez-Larran, Alberto, Triguero, Ana, Iurlo, Alessandra, Bucelli, Cristina, Lunghi, Francesca, Capodanno, Isabella, Maffioli, Margherita, Galimberti, Sara, Caocci, Giovanni, Stagno, Fabio, Saussele, Susanne, Fava, Carmen, le Coutre, Philipp, Bonifacio, Massimiliano, Guglielmana, Veronica, Colombo, Federica, Antolini, Laura, and Gambacorti-Passerini, Carlo

Published
2022
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42. A polymorphism in the XPD gene predisposes to leukemic transformation and new nonmyeloid malignancies in essential thrombocythemia and polycythemia vera

Author

Hernández-Boluda, Juan-Carlos, Pereira, Arturo, Cervantes, Francisco, Alvarez-Larrán, Alberto, Collado, María, Such, Esperanza, Arilla, M. Jesús, Boqué, Concepción, Xicoy, Blanca, Maffioli, Margherita, Bellosillo, Beatriz, Marugán, Isabel, Amat, Paula, Besses, Carles, and Guillem, Vicent

Published
2012
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43. Assessment and prognostic value of the European LeukemiaNet criteria for clinicohematologic response, resistance, and intolerance to hydroxyurea in polycythemia vera

Author

Alvarez-Larrán, Alberto, Pereira, Arturo, Cervantes, Francisco, Arellano-Rodrigo, Eduardo, Hernández-Boluda, Juan-Carlos, Ferrer-Marín, Francisca, Angona, Anna, Gómez, Montse, Muiña, Begoña, Guillén, Helga, Teruel, Anabel, Bellosillo, Beatriz, Burgaleta, Carmen, Vicente, Vicente, and Besses, Carles

Published
2012
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45. Impact of ruxolitinib on survival of patients with myelofibrosis in the real world: update of the ERNEST Study

Author

Guglielmelli, Paola, Ghirardi, Arianna, Carobbio, Alessandra, Masciulli, Arianna, Maccari, Chiara, Mora, Barbara, Rumi, Elisa, Triguero, Ana, Finazzi, Maria Chiara, Pettersson, Helna, Paoli, Chiara, Mannelli, Francesco, Vanni, Daniele, Rambaldi, Alessandro, Passamonti, Francesco, Alvarez-Larràn, Alberto, Andreasson, Bjorn, Vannucchi, Alessandro M., and Barbui, Tiziano

Published
2022
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46. Appropriate management of polycythaemia vera with cytoreductive drug therapy: European LeukemiaNet 2021 recommendations

Author

Monia Marchetti, Alessandro Maria Vannucchi, Martin Griesshammer, Claire Harrison, Steffen Koschmieder, Heinz Gisslinger, Alberto Álvarez-Larrán, Valerio De Stefano, Paola Guglielmelli, Francesca Palandri, Francesco Passamonti, Giovanni Barosi, Richard T Silver, Rüdiger Hehlmann, Jean-Jacques Kiladjian, and Tiziano Barbui

Subjects
Splenomegaly, Quality of Life, Humans, Hydroxyurea, Hematology, Cytoreduction Surgical Procedures, Polycythemia Vera
Abstract

Polycythaemia vera is associated with a reduced quality of life, a high rate of vascular events, and an intrinsic risk of disease evolution. The results of several randomised trials for the treatment of this disorder are now available, and both a new ropegylated formulation of interferon alfa-2b (ropeginterferon alfa-2b; 2018) and ruxolitinib (2015) have been approved in Europe. European LeukemiaNet (ELN) investigators have therefore deemed it appropriate to provide recommendations for the use of these drugs in clinical practice. An expert panel of 14 senior haematologists from ELN centres that had actively participated in previous ELN projects or relevant randomised trials, chaired by a member of the ELN Steering Committee, developed a list of clinical questions, and a methodologist established three patient, intervention, comparator, outcome (PICO) questions and systematically reviewed the evidence. Recommendations were approved by six Delphi consensus rounds and two virtual meetings (on Jan 26, 2021, and June 24, 2021). The expert panel recommended that patients with polycythaemia vera who are younger than 60 years and have not had previous thrombotic events should start cytoreductive drug therapy if at least one of the following criteria are fulfilled: strictly defined intolerance to phlebotomy, symptomatic progressive splenomegaly, persistent leukocytosis (15 × 10

Published
2021

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