1. Neoadjuvant Treatment of Nonfunctioning Pancreatic Neuroendocrine Tumors with [177Lu-DOTA0,Tyr3]Octreotate
- Author
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Bert A. Bonsing, Elisabeth J. M. Nieveen van Dijkum, Eric P. Krenning, Wouter W. de Herder, Ronald R. de Krijger, Casper H.J. van Eijck, Esther I. van Vliet, Richard A Feelders, Tessa Brabander, Jaap J.M. Teunissen, Dik J. Kwekkeboom, Boen J Kam, Radiology & Nuclear Medicine, Surgery, Pathology, Internal Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, and Other Research
- Subjects
Adult ,Male ,neoadjuvant treatment ,Oncology ,medicine.medical_specialty ,medicine.medical_treatment ,Splenectomy ,Kaplan-Meier Estimate ,Neuroendocrine tumors ,Octreotide ,pancreatic neuroendocrine tumor ,Gastroenterology ,Disease-Free Survival ,Pancreaticoduodenectomy ,surgery ,Whipple Procedure ,Young Adult ,chemistry.chemical_compound ,Pancreatectomy ,Pancreatic tumor ,Internal medicine ,[Lu-177-DOTA(0) ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Tyr(3)]octreotate ,Neoplasm Metastasis ,Neoadjuvant therapy ,Aged ,Aged, 80 and over ,Octreotate ,business.industry ,Liver Neoplasms ,Middle Aged ,medicine.disease ,Survival Analysis ,Neoadjuvant Therapy ,[Lu-177-DOTA(0),Tyr(3)]octreotate ,Pancreatic Neoplasms ,chemistry ,Female ,PRRT ,Neoplasm Grading ,Radiopharmaceuticals ,business - Abstract
Pancreatic neuroendocrine tumors (NETs) are rare neoplasms for which surgery has almost the only potential for cure. When surgery is not possible because of tumor size and vascular involvement, neoadjuvant treatment with [Lu-177-DOTA(0),Tyr(3)]octreotate (Lu-177-octreotate) may be an option. Methods: We studied 29 Dutch patients with a pathology-proven nonfunctioning pancreatic NET treated with Lu-177-octreotate. All patients had a borderline or unresectable pancreatic tumor (group 1) or oligometastatic disease (defined as liver metastases) (group 2). Progression-free survival (PFS) was analyzed using the Kaplan Meier method and Cox proportional hazards modeling. Results: After the treatment with Lu-177-octreotate, successful surgery was performed in 9 of 29 patients (31%). Six patients had a Whipple procedure, 2 patients had a pylorus-preserving pancreaticoduodenectomy, and 1 patient had a distal pancreatectomy and splenectomy. The median PFS was 69 mo for patients with successful surgery and 49 mo for the other patients. For comparison, the median PFS in 90 other patients with a nonfunctioning pancreatic NET with more than 3 liver metastases or other metastases was 25 mo. Conclusion: Neoadjuvant treatment with Lu-177-octreotate is a valuable option for patients with initially unresectable pancreatic NETs.
- Published
- 2015
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