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Neoadjuvant Treatment of Nonfunctioning Pancreatic Neuroendocrine Tumors with [177Lu-DOTA0,Tyr3]Octreotate
- Source :
- Journal of Nuclear Medicine, 56(11), 1647-1653. Society of Nuclear Medicine and Molecular Imaging, Journal of nuclear medicine, 56(11), 1647-1653. Society of Nuclear Medicine Inc., Journal of Nuclear Medicine, 56(11), 1647-1653
- Publication Year :
- 2015
- Publisher :
- Society of Nuclear Medicine, 2015.
-
Abstract
- Pancreatic neuroendocrine tumors (NETs) are rare neoplasms for which surgery has almost the only potential for cure. When surgery is not possible because of tumor size and vascular involvement, neoadjuvant treatment with [Lu-177-DOTA(0),Tyr(3)]octreotate (Lu-177-octreotate) may be an option. Methods: We studied 29 Dutch patients with a pathology-proven nonfunctioning pancreatic NET treated with Lu-177-octreotate. All patients had a borderline or unresectable pancreatic tumor (group 1) or oligometastatic disease (defined as liver metastases) (group 2). Progression-free survival (PFS) was analyzed using the Kaplan Meier method and Cox proportional hazards modeling. Results: After the treatment with Lu-177-octreotate, successful surgery was performed in 9 of 29 patients (31%). Six patients had a Whipple procedure, 2 patients had a pylorus-preserving pancreaticoduodenectomy, and 1 patient had a distal pancreatectomy and splenectomy. The median PFS was 69 mo for patients with successful surgery and 49 mo for the other patients. For comparison, the median PFS in 90 other patients with a nonfunctioning pancreatic NET with more than 3 liver metastases or other metastases was 25 mo. Conclusion: Neoadjuvant treatment with Lu-177-octreotate is a valuable option for patients with initially unresectable pancreatic NETs.
- Subjects :
- Adult
Male
neoadjuvant treatment
Oncology
medicine.medical_specialty
medicine.medical_treatment
Splenectomy
Kaplan-Meier Estimate
Neuroendocrine tumors
Octreotide
pancreatic neuroendocrine tumor
Gastroenterology
Disease-Free Survival
Pancreaticoduodenectomy
surgery
Whipple Procedure
Young Adult
chemistry.chemical_compound
Pancreatectomy
Pancreatic tumor
Internal medicine
[Lu-177-DOTA(0)
medicine
Humans
Radiology, Nuclear Medicine and imaging
Tyr(3)]octreotate
Neoplasm Metastasis
Neoadjuvant therapy
Aged
Aged, 80 and over
Octreotate
business.industry
Liver Neoplasms
Middle Aged
medicine.disease
Survival Analysis
Neoadjuvant Therapy
[Lu-177-DOTA(0),Tyr(3)]octreotate
Pancreatic Neoplasms
chemistry
Female
PRRT
Neoplasm Grading
Radiopharmaceuticals
business
Subjects
Details
- ISSN :
- 2159662X and 01615505
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Journal of Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....bcadd48914a97791ccb56b69580a10ba
- Full Text :
- https://doi.org/10.2967/jnumed.115.158899