1. Role of sex hormones in modulating myocardial perfusion and coronary flow reserve
- Author
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Ahmed Haider, Susan Bengs, Angela Portmann, Alexia Rossi, Hazem Ahmed, Dominik Etter, Geoffrey I. Warnock, Nidaa Mikail, Muriel Grämer, Alexander Meisel, Livio Gisler, Caitlin Jie, Claudia Keller, Sebastian Kozerke, Bruno Weber, Roger Schibli, Linjing Mu, Philipp A. Kaufmann, Vera Regitz-Zagrosek, Simon M. Ametamey, Catherine Gebhard, University of Zurich, and Gebhard, Catherine
- Subjects
Male ,Res/stress myocardial perfusion imaging (MPI) ,Positron emission tomography (PET) ,[18F]furpiridaz ,Sex hormones ,Sex differences ,Coronary fow reserve (CFR) ,610 Medicine & health ,Coronary Artery Disease ,Ventricular Function, Left ,Mice ,Animals ,Humans ,2741 Radiology, Nuclear Medicine and Imaging ,Testosterone ,Radiology, Nuclear Medicine and imaging ,Gonadal Steroid Hormones ,Myocardial Perfusion Imaging ,Stroke Volume ,General Medicine ,10181 Clinic for Nuclear Medicine ,Perfusion ,Positron-Emission Tomography ,Female ,Tomography, X-Ray Computed - Abstract
Background A growing body of evidence highlights sex differences in the diagnostic accuracy of cardiovascular imaging modalities. Nonetheless, the role of sex hormones in modulating myocardial perfusion and coronary flow reserve (CFR) is currently unclear. The aim of our study was to assess the impact of female and male sex hormones on myocardial perfusion and CFR. Methods Rest and stress myocardial perfusion imaging (MPI) was conducted by small animal positron emission tomography (PET) with [F-18]flurpiridaz in a total of 56 mice (7-8 months old) including gonadectomized (Gx) and sham-operated males and females, respectively. Myocardial [F-18]flurpiridaz uptake (% injected dose per mL, % ID/mL) was used as a surrogate for myocardial perfusion at rest and following intravenous regadenoson injection, as previously reported. Apparent coronary flow reserve (CFRApp) was calculated as the ratio of stress and rest myocardial perfusion. Left ventricular (LV) morphology and function were assessed by cardiac magnetic resonance (CMR) imaging. Results Orchiectomy resulted in a significant decrease of resting myocardial perfusion (Gx vs. sham, 19.4 +/- 1.0 vs. 22.2 +/- 0.7 % ID/mL, p = 0.034), while myocardial perfusion at stress remained unchanged (Gx vs. sham, 27.5 +/- 1.2 vs. 27.3 +/- 1.2 % ID/mL, p = 0.896). Accordingly, CFRApp was substantially higher in orchiectomized males (Gx vs. sham, 1.43 +/- 0.04 vs. 1.23 +/- 0.05, p = 0.004), and low serum testosterone levels were linked to a blunted resting myocardial perfusion (r = 0.438, p = 0.020) as well as an enhanced CFRApp (r = -0.500, p = 0.007). In contrast, oophorectomy did not affect myocardial perfusion in females. Of note, orchiectomized males showed a reduced LV mass, stroke volume, and left ventricular ejection fraction (LVEF) on CMR, while no such effects were observed in oophorectomized females. Conclusion Our experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients., European Journal of Nuclear Medicine and Molecular Imaging, 49, ISSN:1619-7070, ISSN:1619-7089
- Published
- 2022