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Role of sex hormones in modulating myocardial perfusion and coronary flow reserve
- Source :
- European Journal of Nuclear Medicine and Molecular Imaging, 49
- Publication Year :
- 2022
-
Abstract
- Background A growing body of evidence highlights sex differences in the diagnostic accuracy of cardiovascular imaging modalities. Nonetheless, the role of sex hormones in modulating myocardial perfusion and coronary flow reserve (CFR) is currently unclear. The aim of our study was to assess the impact of female and male sex hormones on myocardial perfusion and CFR. Methods Rest and stress myocardial perfusion imaging (MPI) was conducted by small animal positron emission tomography (PET) with [F-18]flurpiridaz in a total of 56 mice (7-8 months old) including gonadectomized (Gx) and sham-operated males and females, respectively. Myocardial [F-18]flurpiridaz uptake (% injected dose per mL, % ID/mL) was used as a surrogate for myocardial perfusion at rest and following intravenous regadenoson injection, as previously reported. Apparent coronary flow reserve (CFRApp) was calculated as the ratio of stress and rest myocardial perfusion. Left ventricular (LV) morphology and function were assessed by cardiac magnetic resonance (CMR) imaging. Results Orchiectomy resulted in a significant decrease of resting myocardial perfusion (Gx vs. sham, 19.4 +/- 1.0 vs. 22.2 +/- 0.7 % ID/mL, p = 0.034), while myocardial perfusion at stress remained unchanged (Gx vs. sham, 27.5 +/- 1.2 vs. 27.3 +/- 1.2 % ID/mL, p = 0.896). Accordingly, CFRApp was substantially higher in orchiectomized males (Gx vs. sham, 1.43 +/- 0.04 vs. 1.23 +/- 0.05, p = 0.004), and low serum testosterone levels were linked to a blunted resting myocardial perfusion (r = 0.438, p = 0.020) as well as an enhanced CFRApp (r = -0.500, p = 0.007). In contrast, oophorectomy did not affect myocardial perfusion in females. Of note, orchiectomized males showed a reduced LV mass, stroke volume, and left ventricular ejection fraction (LVEF) on CMR, while no such effects were observed in oophorectomized females. Conclusion Our experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients.<br />European Journal of Nuclear Medicine and Molecular Imaging, 49<br />ISSN:1619-7070<br />ISSN:1619-7089
- Subjects :
- Male
Res/stress myocardial perfusion imaging (MPI)
Positron emission tomography (PET)
[18F]furpiridaz
Sex hormones
Sex differences
Coronary fow reserve (CFR)
610 Medicine & health
Coronary Artery Disease
Ventricular Function, Left
Mice
Animals
Humans
2741 Radiology, Nuclear Medicine and Imaging
Testosterone
Radiology, Nuclear Medicine and imaging
Gonadal Steroid Hormones
Myocardial Perfusion Imaging
Stroke Volume
General Medicine
10181 Clinic for Nuclear Medicine
Perfusion
Positron-Emission Tomography
Female
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 16197070 and 16197089
- Database :
- OpenAIRE
- Journal :
- European Journal of Nuclear Medicine and Molecular Imaging, 49
- Accession number :
- edsair.doi.dedup.....e7ab3b9036255eba13028046afb8529b