324 results on '"Clarke, Michael J"'
Search Results
302. Carbonic anhydrase: An insight into the zinc binding site and into the active cavity through metal substitution
- Author
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Bertini, Ivano, Luchinat, Claudio, Scozzafava, Andrea, Clarke, Michael J., editor, Goodenough, John B., editor, Hemmerich, Peter, editor, Ibers, James A., editor, Klixbüll Jørgensen, C., editor, Neilands, Joe B., editor, Reinen, Dirk, editor, Weiss, Raymond, editor, Williams, Robert Joseph P., editor, Bertini, I., Hemmerich, P., Livorness, J., Luchinat, C., Massey, V., Michel, H., Schug, C., Scozzafava, A., and Smith, T. D.
- Published
- 1982
- Full Text
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303. Visible light induced cleavage of water into hydrogen and oxygen in colloidal and microheterogeneous systems
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Kiwi, John, Kalyanasundaram, Kuppuswamy, Grätzel, Michael, Clarke, Michael J., editor, Goodenough, John B., editor, Ibers, James A., editor, Jørgensen, C. Klixbüll, editor, Neilands, Joe B., editor, Reinen, Dirk, editor, Weiss, Raymond, editor, Williams, Robert Joseph P., editor, Grätzel, M., Jørgensen, C. K., Kalyanasundaram, K., Kiwi, J., Reisfeld, R., and Tributsch, H.
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- 1982
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304. The role of manganese in photosynthesis
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Livorness, John, Smith, Thomas D., Clarke, Michael J., editor, Goodenough, John B., editor, Hemmerich, Peter, editor, Ibers, James A., editor, Klixbüll Jørgensen, C., editor, Neilands, Joe B., editor, Reinen, Dirk, editor, Weiss, Raymond, editor, Williams, Robert Joseph P., editor, Bertini, I., Hemmerich, P., Livorness, J., Luchinat, C., Massey, V., Michel, H., Schug, C., Scozzafava, A., and Smith, T. D.
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- 1982
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305. Scope and limitation of single electron transfer in biology
- Author
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Hemmerich, Peter, Massey, Vincent, Michel, Heinrich, Schug, Christian, Clarke, Michael J., editor, Goodenough, John B., editor, Hemmerich, Peter, editor, Ibers, James A., editor, Klixbüll Jørgensen, C., editor, Neilands, Joe B., editor, Reinen, Dirk, editor, Weiss, Raymond, editor, Williams, Robert Joseph P., editor, Bertini, I., Hemmerich, P., Livorness, J., Luchinat, C., Massey, V., Michel, H., Schug, C., Scozzafava, A., and Smith, T. D.
- Published
- 1982
- Full Text
- View/download PDF
306. Spin crossover in iron(II)-complexes
- Author
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Gütlich, Philipp, Clarke, Michael J., editor, Goodenough, John B., editor, Hemmerich, Peter, editor, Ibers, James A., editor, Jørgensen, C. Klixbüll, editor, Neilands, Joe B., editor, Reinen, Dirk, editor, Weiss, Raymond, editor, Williams, Robert Joseph P., editor, Bau, R., Gütlich, P., and Teller, R. G.
- Published
- 1981
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307. Electron nuclear double resonance of transition metal complexes with organic ligands
- Author
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Schweiger, Arthur, Clarke, Michael J., editor, Goodenough, John B., editor, Ibers, James A., editor, Jørgensen, C. Klixbüll, editor, Neilands, Joe B., editor, Reinen, Dirk, editor, Weiss, Raymond, editor, Williams, Robert Joseph P., editor, and Schweiger, A.
- Published
- 1982
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308. Crystallographic studies of transition metal hydride complexes
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Teller, Raymond G., Bau, Robert, Clarke, Michael J., editor, Goodenough, John B., editor, Hemmerich, Peter, editor, Ibers, James A., editor, Jørgensen, C. Klixbüll, editor, Neilands, Joe B., editor, Reinen, Dirk, editor, Weiss, Raymond, editor, Williams, Robert Joseph P., editor, Bau, R., Gütlich, P., and Teller, R. G.
- Published
- 1981
- Full Text
- View/download PDF
309. Prosthetic joint infection of the knee - arthroscopic biopsy identifies more and different organisms than aspiration alone.
- Author
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Clarke MJH, Salar O, Evans JP, Bayley MGR, Waterson BH, Toms AD, and Phillips JRA
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- Biopsy, Humans, Knee Joint surgery, Retrospective Studies, Arthritis, Infectious, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee adverse effects, Prosthesis-Related Infections diagnosis, Prosthesis-Related Infections surgery
- Abstract
Background: Prosthetic joint infection (PJI) causes significant morbidity and mortality following knee replacement surgery. Identifying causative organisms and antibiotic sensitivities is critical in increasing the chance of infection eradication. This study investigated whether biopsy alone was superior to aspiration alone for serological diagnosis in PJI following knee replacement. Secondly, we investigated whether biopsy identifies the same or new/different microbiological flora as aspiration., Methods: Since December 2014, the Exeter Knee Reconstruction Unit (EKRU) has prospectively collated data regarding all PJIs referred from our local/regional network which have been reviewed via our Multi-Disciplinary Team (MDT). We identified and included consecutive patients from this MDT from Dec.2014-Mar.2020 and analysed their electronic records. Statistical analysis was performed using Stata., Results: 65/100 patients studied had both pre-operative aspiration and biopsy. 31/65 (48%) had positive aspiration and biopsies. No aspirate samples were positive with corresponding biopsies negative. In 19/65 (29%) of infection positive patients, biopsy identified new (7) or additional (12) organisms not identified by aspiration. Aspiration had a sensitivity of 70%, specificity of 88%, positive predictive value of 90.3% and negative predictive value of 64.7%. Biopsy had a sensitivity of 97.5%, specificity of 88%, positive predictive value of 92.9% and negative predictive value of 95.7%., Conclusion: In 29% of confirmed PJI cases, arthroscopic biopsy identified either additional organisms in a polymicrobial PJI when compared to aspiration, or new positive results when aspiration alone was negative. This study demonstrates the benefits of arthroscopic biopsy for serological diagnosis in cases of knee PJI and aids treatment planning., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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310. Safety of limb-salvaging surgery for sarcomas compromising major vessels: A 15-year single-centre outcomes study.
- Author
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Berner JE, Dearden A, Magdum AA, Crowley TP, Rankin K, Clarke MJ, and Ragbir M
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- Adolescent, Adult, Aged, Aged, 80 and over, Blood Vessel Prosthesis, Child, Combined Modality Therapy, Female, Humans, Limb Salvage adverse effects, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local surgery, Postoperative Complications, Retrospective Studies, Sarcoma pathology, Soft Tissue Neoplasms pathology, Survival Analysis, Vascular Surgical Procedures adverse effects, Veins transplantation, Young Adult, Limb Salvage methods, Sarcoma surgery, Soft Tissue Neoplasms surgery, Vascular Surgical Procedures methods
- Abstract
Introduction: Limb-threatening sarcomas invading major vessels present an oncological and reconstructive challenge. Curative resection involves either performing an amputation or an immediate reconstruction of the invaded vessels. We present our 15-year experience of these cases at the North of England Bone and Soft Tissue Tumour Service., Materials and Methods: A Strengthening the Reporting of Observational studies in Epidemiology (STROBE) compliant retrospective review of our prospective database was performed including patients who required major vessel reconstruction following sarcoma excision from 2003 until 2018. Patient demographic data along with tumour and histological subtypes, treatment modality, complications and outcomes were inquired. Autologous and prosthetic vessel reconstruction approaches were compared., Results: Nineteen patients were identified with the most common tumour locations being the thigh and groin areas. Five cases involved recurrent tumours. Clear resection margins were obtained in 15 cases. Autologous vein grafts were preferred over polytetrafluoroethylene (PTFE) prosthesis in 17 cases. A pedicled flap or free flap was required to achieve adequate soft tissue cover in six patients, while the rest underwent primary closure. Five patients lost the patency of the reconstructed vessels with one of these requiring an amputation. The estimated disease-specific survival at 5 years was 58%., Discussion: Limb-preservation surgery in the context of vessel compromise is not only safe, but also a functionally and psychosocially beneficial means of avoiding an amputation. We believe that careful pre-operative planning and discussion in a multidisciplinary setting is key for obtaining positive outcomes., Competing Interests: Declaration of Competing Interest None declared., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
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311. Alpha particle autoradiography for high spatial resolution mapping of radionuclides.
- Author
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Kalnins CAG, Spooner NA, Clarke MJP, and Ottaway D
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- Half-Life, Alpha Particles, Autoradiography, Radioisotopes analysis
- Abstract
An autoradiographic technique capable of determining the spatial location of radioactive isotopes within materials on the scale of micrometers is demonstrated in low-activity mineral samples, where the concentrations of radionuclides with short half lives is small and below the detection limits of current measurement techniques. The location of certain radionuclide species within samples with complex structures on the micron scale can yield valuable information, however current methods do not have the spatial resolution required for this purpose. We demonstrate the use of an autoradiographic emulsion to directly image alpha particle events in samples with low radionuclide concentrations, allowing spatial resolution of radionuclide locations on the order of several microns. Exposure over a long time period allows sufficient integration of decay events enabling analysis of samples with low activity but large area, (less than 1×10
-4 Bq/mm2 ). The use of polarising filters to increase contrast between the alpha particle tracks and the substrate during imaging demonstrates the viability of the technique on samples with a complex structure., (Copyright © 2018. Published by Elsevier Ltd.)- Published
- 2019
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312. Bilateral testicular torsion in a 36-week neonate.
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Clarke MJH, Crocker S, Bartle DG, and Apsey J
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- Fetal Macrosomia, Follicle Stimulating Hormone blood, Humans, Infant, Newborn, Luteinizing Hormone blood, Male, Rare Diseases congenital, Rare Diseases diagnosis, Rare Diseases drug therapy, Spermatic Cord Torsion diagnostic imaging, Spermatic Cord Torsion drug therapy, Testis blood supply, Testis diagnostic imaging, Testosterone administration & dosage, Testosterone blood, Hormone Replacement Therapy, Spermatic Cord Torsion congenital, Testis abnormalities
- Abstract
A male neonate born after uncomplicated vaginal delivery at 36 weeks' gestation was noted to have large and firm testicles bilaterally on routine examination. A testicular ultrasound scan was subsequently organised that showed detailed appearances consistent with bilateral testicular torsion. This was thought to have taken place antenatally and as such was unfortunately not suitable for intervention. The patient was therefore managed conservatively with the testicles left to involute naturally. He was started on testosterone replacement therapy after follow-up when gonadotrophin levels were found to be raised and testosterone low (suggesting absent testicular function) and will be closely followed up regarding his future development which is normal to this point., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
- Published
- 2018
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313. Operative and 1-Year Outcomes of the Custom-Made Fenestrated Anaconda Aortic Stent Graft-A UK Multicenter Study.
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Colgan FE, Bungay PM, Burfitt N, Hatrick A, Clarke MJ, Davies AH, Jenkins M, Gerrard D, Quarmby JW, and Williams R
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- Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Aneurysm, Abdominal mortality, Aortic Aneurysm, Abdominal physiopathology, Aortography methods, Blood Vessel Prosthesis Implantation adverse effects, Blood Vessel Prosthesis Implantation mortality, Computed Tomography Angiography, Disease-Free Survival, Endoleak etiology, Endovascular Procedures adverse effects, Endovascular Procedures mortality, England, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Multidetector Computed Tomography, Prosthesis Design, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Vascular Patency, Aortic Aneurysm, Abdominal surgery, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation instrumentation, Endovascular Procedures instrumentation, Stents
- Abstract
Background: Early and 1-year outcomes are presented for fenestrated endovascular aneurysm repair (FEVAR) of complex aortic aneurysmal disease with the custom-made Anaconda fenestrated stent graft in 101 patients., Methods: Retrospective site-reported data from the first 101 elective cases (2010-2014) from 4 UK centers were studied to evaluate patient demographics, aneurysm morphology, clinical success, and 1-year outcomes in patients undergoing fenestrated aneurysm repair with the custom-made Anaconda device., Results: 101 fenestrated grafts (median age 76, 85% male) were implanted with a total of 255 fenestrations (196 renal arteries, 48 superior mesenteric artery, and 11 celiac arteries) with 3% mortality, 98.4% target vessel patency (TVP) at 30 day follow-up. Although 15 type I or III endoleaks were demonstrated at completion angiography, all 10 type Ia endoleaks resolved spontaneously. Survival by Kaplan-Meier analysis was 97% and 91% at 1 month and 1 year, respectively; with 75.8% showing reduction in abdominal aortic aneurysm diameter and only 1 patient with sac expansion. Freedom from loss of TVP was 97.6%., Conclusions: Custom-made fenestrated Anaconda devices demonstrate low procedural mortality and a high rate of technical and clinical success at 30 days and 1 year., (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Published
- 2018
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314. Celiac and Superior/Inferior Mesenteric Angioplasty and Stenting for Chronic Mesenteric Ischemia: A Single-Center Experience.
- Author
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Rajaratnam K, Paraskevas KI, Ramli AH, Shehata A, Jackson R, and Clarke MJ
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- Aged, Aged, 80 and over, Chronic Disease, Female, Humans, Male, Mesenteric Ischemia diagnosis, Mesenteric Vascular Occlusion diagnosis, Middle Aged, Risk Factors, Treatment Outcome, Vascular Surgical Procedures methods, Angioplasty methods, Mesenteric Ischemia surgery, Mesenteric Vascular Occlusion surgery, Stents adverse effects
- Abstract
Angioplasty and stenting emerged as the less invasive treatment options compared to open surgical revascularization for the management of patients with chronic mesenteric ischemia (CMI). However, endovascular techniques may not achieve symptomatic relief in many patients with CMI. We report our results from the endovascular management of patients with CMI. Data were reviewed from 45 patients undergoing celiac and/or mesenteric angioplasty and stenting for CMI, from October 2006 to January 2016. Angioplasty and stenting of celiac and/or mesenteric arteries were successful in relieving symptoms completely in 29 of 45 and partially in 6 of 45 patients. Only 10 of 45 patients mentioned no improvement, while symptom recurrence occurred in another 3 of 45 patients between 3 and 36 months postprocedurally due to stent occlusion. Angioplasty and stenting of celiac and/or mesenteric arteries provide symptomatic relief in a considerable percentage of patients with CMI. If symptoms fail to improve, an open surgical revascularization procedure should be considered.
- Published
- 2017
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315. Effect of normative masculinity on males' dysfunctional sexual beliefs, sexual attitudes, and perceptions of sexual functioning.
- Author
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Clarke MJ, Marks AD, and Lykins AD
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Humans, Male, Middle Aged, Young Adult, Attitude, Masculinity, Sexism psychology, Sexual Behavior psychology, Sexual Dysfunctions, Psychological psychology
- Abstract
Male sexual dysfunction is a prevalent and distressing condition, which may be exacerbated by the sufferer's perceptions of masculinity and normative sexual behavior. This study sought to investigate the effect of social context on males' beliefs regarding sexual behavior. The research examined the effect of male role modeling and masculine cues on males' dysfunctional sexual beliefs, sexual attitudes, and self-perceptions of sexual functioning. A sample of 140 male participants, with a mean age of 29 years, was exposed to pictorial and verbal cues that presented different versions of male behavior across three conditions. Results indicated that males exposed to models and cues of traditional masculinity showed significantly increased levels of dysfunctional sexual beliefs and traditional sexual attitudes relative to males exposed to models of modern masculinity. Results also indicated that males exposed to traditional masculine stimuli reported lower levels of sexual inhibition due to fear of performance failure than males exposed to models of modern masculinity. The potential role of social context is discussed in the development and maintenance of male sexual dysfunction and its implications for treatment.
- Published
- 2015
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316. Multiple mycotic aneurysms infected with Haemophilus influenzae.
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Nath AF and Clarke MJ
- Subjects
- Allografts, Aneurysm, Infected diagnosis, Aneurysm, Infected therapy, Anti-Bacterial Agents administration & dosage, Aortic Aneurysm, Thoracic diagnosis, Aortic Aneurysm, Thoracic therapy, Aortography methods, Bioprosthesis, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation instrumentation, Combined Modality Therapy, Cryopreservation, Haemophilus Infections diagnosis, Haemophilus Infections therapy, Humans, Male, Middle Aged, Tomography, X-Ray Computed, Treatment Outcome, Aneurysm, Infected microbiology, Aortic Aneurysm, Thoracic microbiology, Haemophilus Infections microbiology, Haemophilus influenzae isolation & purification
- Abstract
Mycotic aneurysms are a relatively uncommon phenomenon that can pose a distinct treatment dilemma for the treating surgeon. It is rare to find Haemophilus influenzae as the causative organism, and it is even more rare to find multiple aneurysms in the same patient. We present the first case to our knowledge to be described in the literature of multiple mycotic aneurysms caused by H. influenzae. The treatment presented-using high-dose antibiotics and cryopreserved homografts-has worked well in this instance. This approach is supported in the literature., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
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317. Second Evidence Aid Conference: prioritizing evidence in disaster aid.
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Vandekerckhove P, Clarke MJ, De Buck E, Allen C, and Kayabu B
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- Congresses as Topic, Disaster Planning standards, Evidence-Based Emergency Medicine methods, Health Priorities, Humans, Altruism, Disaster Planning organization & administration, Evidence-Based Emergency Medicine standards, International Cooperation
- Abstract
The Second Evidence Aid Conference took place in Brussels, Belgium, in October 2012, jointly organized by Evidence Aid and the Belgian Red Cross-Flanders. It provided an opportunity to build on the discussions from the 2011 First Evidence Aid Conference in Oxford, England, and prioritize the future work of Evidence Aid. Within the plenary presentations, discussions, and small work groups, the more than 80 international participants addressed issues regarding the need, use, and prioritization of evidence. Three parallel workshops focused on the prioritization of research, systematic reviews, and data to be collected during disasters, leading to a suggested prioritization framework and a commitment to identify key areas for evidence in disasters. Working with a wide variety of people and organizations from the disaster and humanitarian sectors, Evidence Aid will take this framework and develop a list of top priority questions in need of research and systematic reviews. Although Evidence Aid will not be able to address all of the research questions that will be identified in this process, it will collect them for sharing with relevant agencies. (Disaster Med Public Health Preparedness. 2013;7:593-596).
- Published
- 2013
- Full Text
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318. Diagnosis and laparoscopic management of adult intussusception.
- Author
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Wan WH, Lee J, Clarke MJ, and Cheng A
- Subjects
- Adult, Female, Humans, Intussusception diagnosis, Intussusception surgery, Laparoscopy
- Published
- 2009
- Full Text
- View/download PDF
319. Solid-state changes in ligand-to-metal charge-transfer spectra of (NH3)5Ru(III)(2,4-dihydroxybenzoate) and (NH3)5Ru(III)(xanthine) chromophores.
- Author
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Krogh-Jespersen K, Stibrany RT, John E, Westbrook JD, Emge TJ, Clarke MJ, Potenza JA, and Schugar HJ
- Abstract
Five distorted-octahedral complexes containing (NH3)5Ru(III)L ions, where L = 2,4-dihydroxybenzoate or a xanthine, have been studied using a combination of X-ray crystallography, solution and polarized single-crystal electronic absorption spectroscopy, and first principles electronic structure computational techniques. Both yellow (2) and red (3) forms of the complex (NH3)5Ru(III)L, where L = 2,4-dihydroxybenzoate, as well as three xanthine complexes in which L = hypoxanthine-kappaN(7) (4), 7-methylhypoxanthine-kappaN(9) (5), and 1,3,9-trimethylxanthine-kappaN(7) (6) were examined. In the solid state, some of these complexes exhibit split low-energy ligand-to-metal charge-transfer (LMCT) bands. Traditional solid-state effects, such as ligand pi-pi overlap or hydrogen bonding that might lead to splitting of electronic absorption bands, were probed in an attempt to identify the origins of these unusual observations. For comparison, companion studies were carried out for spectroscopically normal reference complexes of the same ligands. Time-dependent density-functional theory (TD-DFT) calculations, employing modified B3LYP-type functionals with increased contributions of exact exchange, attribute the color change in the crystalline complexes 2 and 3 to pi(ligand) --> Ru[d(pi)] LMCT bands which, in the red form (3), arise from ligand donor pi-orbitals split by strongly overlapping phenyl moieties in centrosymmetric (NH3)5Ru(III)(2,4-dihydroxybenzoate) dimers. Complex 5 does not show split visible absorptions, whereas both the polarizations and energies of the split visible absorptions shown by 4 and 6 also suggest assignment as LMCT. No support is found for relating the split absorptions of 4 and 6 to the details of pi-pi xanthine overlap in the solid state; indeed, complex 4 enjoys considerably less pi-stacking overlap than does 5. We feel compelled to attribute the split absorptions in crystalline 4 and 6 to the emergence of a LMCT transition originating in the carbonyl lone pair, potentially deriving intensity from the significant intramolecular N-H...O hydrogen bonding present in both 4 and 6 (but not in 5). The electronic structure calculations suggest an O(n) --> Ru[d(sigma*)] LMCT transition; however, this novel assignment must be considered tentative.
- Published
- 2008
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- View/download PDF
320. Individual patient data meta-analyses.
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Clarke MJ
- Subjects
- Data Collection, Humans, Medical Records Systems, Computerized, Randomized Controlled Trials as Topic, Data Interpretation, Statistical, Evidence-Based Medicine methods, Meta-Analysis as Topic, Review Literature as Topic
- Abstract
Systematic reviews help people to make well-informed decisions about health care by bringing together the relevant evidence, appraising it and, where appropriate, combining it in a meta-analysis. The ultimate aim for a systematic review should be to present all relevant data on all participants in all research judged to be eligible for the review. In reviews of the effects of interventions, this ultimate aim would be met through the collection and analyses of the results of all relevant randomized trials. Reviews that use individual patient data achieve this by the central collection and analyses of data on each participant in the trials. It allows the reviewer to overcome many of the problems associated with a reliance on published data alone, and some of the problems associated with using aggregate data supplied by the trialist, and will add to the analyses that can be performed. This chapter discusses the rationale for individual patient data reviews and describes some of their features.
- Published
- 2005
- Full Text
- View/download PDF
321. Autologous deep vein reconstruction of infected thoracoabdominal aortic patch graft.
- Author
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Tambyraja AL, Wyatt MG, Clarke MJ, and Chalmers RT
- Subjects
- Adult, Aorta pathology, Constriction, Pathologic, Humans, Male, Prosthesis-Related Infections diagnosis, Staphylococcal Infections diagnosis, Staphylococcal Infections surgery, Aorta surgery, Blood Vessel Prosthesis Implantation adverse effects, Femoral Vein transplantation, Prosthesis-Related Infections surgery
- Abstract
Graft infection remains a serious complication of prosthetic aortic repair. Infection of thoracoabdominal aortic prosthetic grafts, in particular, is a significant clinical challenge and is associated with high mortality. We report successful in situ reconstruction of an infected thoracoabdominal aortic prosthetic patch graft with autogenous superficial femoral vein. To our knowledge, this is the first such case described in the North American and English language surgical literature. At 24-month follow-up the patient remains well, with no evidence of sepsis or graft complication at clinical and radiologic assessment.
- Published
- 2003
- Full Text
- View/download PDF
322. Uterine arteriovenous malformation: a rare cause of uterine bleeding. Diagnosis and treatment.
- Author
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Clarke MJ and Mitchell PJ
- Subjects
- Adult, Angiography, Arteriovenous Malformations diagnosis, Arteriovenous Malformations diagnostic imaging, Arteriovenous Malformations therapy, Embolization, Therapeutic, Female, Humans, Ultrasonography, Arteriovenous Malformations complications, Uterine Hemorrhage etiology, Uterus blood supply
- Abstract
A case of uterine arteriovenous malformation following a dilatation and curettage is presented. Initial diagnosis with colour and pulsed Doppler ultrasound and treatment with transcatheter arterial embolization are described.
- Published
- 2003
- Full Text
- View/download PDF
323. A descriptive study of randomized trials of treatments for childhood acute lymphoblastic leukaemia.
- Author
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Burrett JA and Clarke MJ
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Humans, Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy, Randomized Controlled Trials as Topic
- Abstract
This report presents a historical and descriptive account of randomized trials in childhood leukaemia since the earliest such studies in the 1960s. It focuses on trials that began before 1988, making use of the register of trials developed for a systematic review of treatments for acute lymphoblastic leukaemia in children. The number of randomized trials starting each year increased from one or two in the 1960s to an annual average of five or six in the 1980s. However trials remained relatively small, with more than half of all randomizations accruing less than 200 patients and only five having more than 1000. Most trials were published more than once.
- Published
- 2002
- Full Text
- View/download PDF
324. In vivo effects of the controlled NO donor/scavenger ruthenium cyclam complexes on blood pressure.
- Author
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Marcondes FG, Ferro AA, Souza-Torsoni A, Sumitani M, Clarke MJ, Franco DW, Tfouni E, and Krieger MH
- Subjects
- Animals, Cell Division drug effects, Cyclic N-Oxides pharmacology, Free Radical Scavengers pharmacology, Imidazoles pharmacology, Male, Methylene Blue pharmacology, NG-Nitroarginine Methyl Ester pharmacology, Nitric Oxide metabolism, Nitroprusside pharmacology, Rats, Rats, Wistar, Blood Pressure drug effects, Heterocyclic Compounds pharmacology, Hypertension metabolism, Hypotension drug therapy, Nitric Oxide pharmacology, Ruthenium pharmacology
- Abstract
Ruthenium(II/III) complexes able to bind and release NO* were tested in vivo, in conscious Wistar rats instrumented for continuous blood pressure (BP) measurement and administration of in bolus injections (5 to 100 nmol/Kg i.v.) of trans-[Ru(II)Cl(NO+)(cyclam)](PF6)2 (cyclam-NO) or sodium nitroprusside (SNP). For normotensive rats, cyclam-NO produced a sustained 10% BP reduction of basal MAP during 7 +/- 0.4 to 11 +/- 0.3 min. In acute hypertensive rats, cyclam-NO produced BP reduction 3-fold larger than in normotensive rats and similar to that of SNP (maximal effect: 41 +/- 1.3 vs. 45 +/- 2.2 mmHg, respectively). However, the duration of the effect of cyclam-NO was 13 to 21-fold longer than that of SNP. The hypotensive effect of cyclam-NO was fully blocked in presence of continuous infusion of a NO* scavenger, carboxy-PTIO (6 mmol/Kg/min), or of the inhibitor of cGMP activation, methylene blue (83 nmol/Kg/min), or of the cyclam-NO precursor, trans-[RuCl(tfins)(cyclam)](tfms) (cyclam-tfms) (500 mmol/Kg/min). The long lasting BP reduction of cyclam-NO can be interpreted in terms of a slower rate of NO* release (k-NO = 2.2 x 10(-3) S(-1) at 35 degrees C) following chemical reduction (E(0') = 0.10 V vs NHE). In summary, cyclam-NO showed an hypotensive effect around 20 times longer than SNP in either normotensive or hypertensive rats, which was completely inhibited by methylene blue or carboxy-PTIO. Continuous infusion of cyclam-tfms completely blocked the hypotensive effect of cyclam-NO by scavenging the NO* released by the reduced cyclam-NO.
- Published
- 2002
- Full Text
- View/download PDF
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