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364. Reduced plasma concentrations of alpha- tocopherol and beta-carotene in obese boys

Author

Decsi, T., Molnar, D., and Koletzko, B.

Abstract

Plasma @a-tocopherol and @b-carotene concentrations were significantly lower in obese boys than in control subjects (medians: 3.41 versus 7.46 mg/L and 0.038 versus 0.078 mg/L, respectively, p <0.05). The differences remained significant after correction for lipidemia. These reduced plasma concentrations of the major lipid-soluble antioxidants in obese children may add to the increased risk of cardiovascular disease in obesity.(J Pediatr 1997;130:653-5)

Published
1997
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366. Erratum: Percentile reference values for anthropometric body composition indices in European children from the IDEFICS study

Author

Nagy, P, Intemann, T, Buck, C, Pigeot, I, Ahrens, W, and Molnar, D

Abstract

Correction to: International Journal of Obesity (2014) 38, S15–S25; doi:10.1038/ijo.2014.131 Following the publication of the anthropometric reference values for children1 the authors were notified of a mistake in calculating the fat mass index (FMI). Erroneously FMI was calculated with percent bodyfat instead of absolute body fat mass.

Published
2016
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367. A blind ATCA HI survey of the Fornax galaxy cluster

Author

Loni, A., Serra, P., Kleiner, D., Cortese, L., Catinella, B., Koribalski, B., Jarrett, T. H., Molnar, D. Cs., Davis, T. A., Iodice, E., Lee-Waddell, K., Loi, F., Maccagni, F. M., Peletier, R., Popping, A., Ramatsoku, M., Smith, M. W. L., and Zabel, N.

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368. Comparative microstructural and corrosion development of VCrNiCoFeCu equiatomic multicomponent alloy produced by induction melting and spark plasma sintering

Author

Fazakas, E, Heczel, A, Molnar, D, Varga, B, and, Zadorozhnyy, and Vida, A

Abstract

The present study focuses on the corrosion behavior of a single-phase FCC high entropy alloy (VCrNiCoFeCu) casted by two different methods: induction melting and spark plasma sintering. The corrosion resistance has been evaluated using immersion tests in 3.5% NaCl solution, the potentiodynamic polarization measurements and the results are compared how is dependent the corrosion rate as a function of the production methods. Our results show that induction melted sample is stable in salty environment. On the other hand, based on the changes of polarization curves, there must be an evolution of oxide films on the SPSed sample until reaching the stable oxide layer.

Published
2018

369. Championing the use of people‐first language in childhood overweight and obesity to address weight bias and stigma: A joint statement from the European‐Childhood‐Obesity‐Group (ECOG), the European‐Coalition‐for‐People‐Living‐with‐Obesity (ECPO), the International‐Paediatric‐Association (IPA), Obesity‐Canada, the European‐Association‐for‐the‐Study‐of‐Obesity Childhood‐Obesity‐Task‐Force (EASO‐COTF), Obesity Action Coalition (OAC), The Obesity Society (TOS) and the World‐Obesity‐Federation (WOF)

Author

Weghuber, D., Khandpur, N., Boyland, E., Mazur, A., Frelut, M. L., Forslund, A., Vlachopapadopoulou, E., Erhardt, É., Vania, A., Molnar, D., Ring‐Dimitriou, S., Caroli, M., Mooney, V., Forhan, M., Ramos‐Salas, X., Pulungan, A., Holms, J. C., O'Malley, G., Baker, J. L., and Jastreboff, A. M.

Subjects
*BODY weight, *CHILDHOOD obesity, *DISCRIMINATION (Sociology), *PREJUDICES, *SOCIAL stigma, *ACADEMIC achievement, *QUALITY of life, *INTERPERSONAL relations, *DISEASE management, *PUBLIC opinion
Abstract

An editorial is presented on the importance of using people-first language in addressing weight bias and stigma in childhood overweight and obesity. Topics include the negative consequences of weight bias and stigma on children's health and well-being; and the adoption and enforcement of people-first language policies in academic research, healthcare settings, media, and public discourse surrounding childhood obesity.

Published
2023
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375. Dietary sources of free sugars in the diet of European children: the IDEFICS Study.

Author

Graffe, María Isabel Mesana, Pala, V., De Henauw, S., Eiben, G., Hadjigeorgiou, C., Iacoviello, L., Intemann, T., Jilani, H., Molnar, D., Russo, P., Veidebaum, T., and Moreno, L. A.

Subjects
*AUTOMATIC data collection systems, *BEVERAGES, *COMPARATIVE studies, *DAIRY products, *DIET, *FOOD habits, *INGESTION, *LONGITUDINAL method, *MEDICAL cooperation, *NUTRITIONAL assessment, *NUTRITIONAL requirements, *POPULATION geography, *RESEARCH, *SEX distribution, *DESCRIPTIVE statistics, *DIETARY sucrose, *CHILDREN
Abstract

Objective: To report dietary free sugars consumption and their different types and food sources in European children. Methods: The present study is based on the IDEFICS study, a European multicenter cohort study in children (2–9 years old) from eight countries, comprising 8308 children (51.4% males). Dietary intake of the previous 24 h was assessed using a computer-assisted 24-h dietary recalls (24-HDR) and the different types of sugars were assessed using the German food composition database. Results: Mean total energy intake was 1720 (SD 477) kcal/d for boys and 1631 (SD 451) kcal/d for girls. Total sugars intake was 98 (SD 52) g/day for boys and 93 (SD 49) g/day for girls. Free sugars intake was 81 (SD 49) g/day for boys and 77 (SD 47) g/day for girls. Girls had significantly lower intakes of energy, total and free sugars compared with than boys but did not differ in terms of percent of energy from total (23%) or free sugars (18%). There were large variations between countries in average % energy from free sugars (ranging from 13% in Italy to 27% in Germany). Less than 20% of children were within the recommended intake of 10% of energy from free sugars. The food groups that contributed substantially to free sugars intakes were "Fruit juices", "Soft drinks", "Dairy" and "Sweets and candies". Conclusions: The contribution of free sugars to total energy intake in European children is higher than recommendations. The main food contributors to free sugars intake are sweetened beverages ("Fruit juices" and "Soft drinks"). It is especially important to reduce children's intake of free sugars, focusing in target population on certain foods and food groups. [ABSTRACT FROM AUTHOR]

Published
2020
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377. Dietary sources of sugars in adolescents’ diet: the HELENA study.

Author

Mesana, M. I., Hilbig, A., Androutsos, O., Cuenca-García, M., Dallongeville, J., Huybrechts, I., De Henauw, S., Widhalm, K., Kafatos, A., Nova, E., Marcos, A., González-Gross, M., Molnar, D., Gottrand, F., and Moreno, L. A.

Subjects
*CACAO, *CARBONATED beverages, *DIET, *FAMILIES, *CARBOHYDRATE content of food, *HONEY, *INGESTION, *MOTHERHOOD, *PARENTING, *MULTIPLE regression analysis, *SOCIOECONOMIC factors, *EDUCATIONAL attainment, *LIFESTYLES, *DATA analysis software, *DIETARY sucrose
Abstract

Objective: To report dietary sugars consumption and their different types and food sources, in European adolescents.Methods: Food consumption data of selected groups were obtained from 1630 adolescents (45.6% males, 12.5-17.5 years) from the HELENA study using two nonconsecutive 24-h recalls. Energy intake, total sugars and free sugars were assessed using the HELENA-DIAT software. Multiple regression analyses were performed adjusting for relevant confounders.Results: Total sugars intake (137.5 g/day) represented 23.6% and free sugars (110.1 g/day), 19% of energy intake. Girls had significantly lower intakes of energy, carbohydrates, total sugars and free sugars. 94% of adolescents had a consumption of free sugars above 10% of total energy intake. The main food contributor to free sugars was ‘carbonated, soft and isotonic drinks,’ followed by ‘non-chocolate confectionary’ and ‘sugar, honey, jam and syrup.’ Older boys and girls had significantly higher intakes of free sugars from ‘cakes, pies and biscuits.’ Free sugars intake was negatively associated with low socioeconomic status for ‘non-chocolate confectionary’ and ‘sugar, honey and jam’ groups; with low maternal educational level for carbonated and ‘soft drinks,’ ‘sugar, honey and jam,’ ‘cakes and pies’ and ‘breakfast cereals’ groups; and with high paternal educational level for ‘carbonated and soft drinks’ and ‘chocolates’ group.Conclusions: The majority (94%) of studied adolescents consumed free sugars above 10% of daily energy intake. Our data indicate a broad variety in foods providing free sugars. Continued efforts are required at different levels to reduce the intake of free sugars, especially in families with a low educational level. [ABSTRACT FROM AUTHOR]

Published
2018
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380. Experimental Demonstration of Multigigabit Data Communication Using Surface Waves on Twisted-Pair Cables

Author

Ilana Toledano, Syed Sheheryar Bukhari, Ahmed Aziz, Ergin Dinc, Tobias Schaich, Daniel Molnar, Anas Al Rawi, Eloy de Lera Acedo, Michael Crisp, Richard Penty, Toledano, I [0000-0002-0615-6351], Dinc, E [0000-0001-6982-206X], Schaich, T [0000-0001-9636-4308], Molnar, D [0000-0003-4473-6549], Penty, R [0000-0003-4605-1455], and Apollo - University of Cambridge Repository

Subjects
surface wave launcher, twisted pair cables, Electrical and Electronic Engineering, Wired communication, Goubau line, surface waves, DSL technologies, data communication, planar launcher
Abstract

The demand for higher broadband speeds is ever increasing whereas the deployment of full fibre to the premises is slower than initially predicted and remains costly. Solutions exploiting the existing, ubiquitous, copper network and increasing its capacity would be highly beneficial in the near term. One approach is to use surface wave (SW) transmission mode to transmit signals over the existing copper cabling network. We present proof-of-concept experimental SW data transmission on twisted pair cables. A surface wave launcher for low GHz carrier frequency operation is designed and optimised. Experimentally, we demonstrate data rates in excess of 12 Gb/s in a 1.15-3.25 GHz band over a 6.1 m twisted pair cable with an average bit error rate of 2.25×10-5, without coding or feedback implementation. Furthermore, higher frequency bands are tested with data rates up to 3.4 Gb/s displaying their potential for surface wave transmission. S-parameter measurements allow capacity estimations of SW data transmission on longer cable lengths using water-filling algorithms. Our calculations predict over 13 Gb/s capacity on a 100 m cable using a 3.5 GHz transmission bandwidth, this may be further extended by further increases to the bandwidth used for SW transmission.

Published
2022
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382. Sleep time and cardiovascular risk factors in adolescents: The HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study.

Author

Rey-López, J.P., de Carvalho, H.B., de Moraes, A.C.F., Ruiz, J.R., Sjöström, M., Marcos, A., Polito, A., Gottrand, F., Manios, Y., Kafatos, A., Molnar, D., Widhalm, K., De Henauw, S., and Moreno, L.A.

Subjects
*CARDIOVASCULAR diseases risk factors, *EPIDEMIOLOGY, *HEALTH, *SLEEP, *SLEEP disorders in adolescence, *PEDIATRICS, *ADOLESCENT health
Abstract

Highlights: [•] Adolescents’ sleep time was not associated with cardiometabolic risk factors. [•] European adolescents reported a sleep time of 8h per day (median). [•] Beyond sleep duration, other dimensions of sleep may be more important for health. [•] Future epidemiologic studies should be rigorous with the election of confounders. [ABSTRACT FROM AUTHOR]

Published
2014
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383. Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Author

Rodriguez-Martinez, Andrea, Zhou, Bin, Sophiea, Marisa K, Bentham, James, Paciorek, Christopher J, Iurilli, Maria LC, Carrillo-Larco, Rodrigo M, Bennett, James E, Di Cesare, Mariachiara, Taddei, Cristina, Bixby, Honor, Stevens, Gretchen A, Riley, Leanne M, Cowan, Melanie J, Savin, Stefan, Danaei, Goodarz, Chirita-Emandi, Adela, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Malekzadeh, Reza, Miranda, J Jaime, Moon, Jin Soo, Popovic, Stevo R, Sorensen, Thorkild IA, Soric, Maroje, Starc, Gregor, Zainuddin, Ahmad A, Gregg, Edward W, Bhutta, Zulfiqar A, Black, Robert, Ezzati, Majid, Abarca-Gomez, Leandra, Abdeen, Ziad A, Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Rahim, Hanan F Abdul, Abu-Rmeileh, Niveen M, Garba, Jamila Abubakar, Acosta-Cazares, Benjamin, Adams, Robert J, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Aguilar-Salinas, Carlos A, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Othman, Amani Rashed, Al-Raddadi, Rajaa, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alkandari, Abdullah, Alkerwi, Ala'a, Allin, Kristine, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiri, Parisa, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Angquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araujo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Aspelund, Thor, Assah, Felix K, Assuncao, Maria Cecilia F, Aung, May Soe, Auvinen, Juha, Avdicova, Maria, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha V, Jorgensen, Maja Baeksgaard, Baharudin, Azli, Bahijri, Suhad, Baker, Jennifer L, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, Jose R, Baran, Joanna, Barbagallo, Carlo M, Barcelo, Alberto, Barkat, Amina, Barros, Aluisio JD, Barros, Mauro Virgilio Gomes, Basit, Abdul, Bastos, Joao Luiz D, Bata, Iqbal, Batieha, Anwar M, Batista, Rosangela L, Battakova, Zhamilya, Batyrbek, Assembekov, Baur, Louise A, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Lele, Elysee Claude Bika, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Bjorkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boeing, Heiner, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Bovet, Pascal, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, Joao, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Brinduse, Lacramioara, Brophy, Sinead, Bruno, Graziella, Bueno-de-Mesquita, H Bas, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, de Leon, Antonio Cabrera, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gunay, Candido, Ana Paula C, Canete, Felicia, Capanzana, Mario V, Capkova, Nadezda, Capuano, Eduardo, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajus, Jose A, Casanueva, Felipe F, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamukuttan, Snehalatha, Chan, Angelique W, Chan, Queenie, Chaturvedi, Himanshu K, Chaturvedi, Nish, Rahim, Norsyamlina Che Abdul, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chiolero, Arnaud, Chiou, Shu-Ti, Chirlaque, Maria-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Claessens, Frank, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, Coppinger, Tara C, Corpeleijn, Eva, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crampin, Amelia C, Crujeiras, Ana B, Csilla, Semanova, Cucu, Alexandra M, Cui, Liufu, Cureau, Felipe V, D'Arrigo, Graziella, d'Orsi, Eleonora, Dacica, Liliana, Saavedra, Maria Angeles Dal Re, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T, Dankner, Rachel, Dantoft, Thomas M, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, de Oliveira, Paula Duarte, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D, DeGennaro, Vincent, Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Deren, Katarzyna, Deschamps, Valerie, Dhana, Klodian, Dhimal, Meghnath, Di Castelnuovo, Augusto F, Dias-da-Costa, Juvenal Soares, Diaz-Sanchez, Maria Elena, Diaz, Alejandro, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha TP, Dobson, Annette J, Donati, Maria Benedetta, Donfrancesco, Chiara, Donoso, Silvana P, Doring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Doua, Kouamelan, Drygas, Wojciech, Duan, Jia Li, Duante, Charmaine A, Duboz, Priscilla, Duda, Rosemary B, Duleva, Vesselka, Dulskiene, Virginija, Dumith, Samuel C, Dushpanova, Anar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Eddie, Ricky, Eftekhar, Ebrahim, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Eldemire-Shearer, Denise, Eliasen, Marie, Elliott, Paul, Engle-Stone, Reina, Enguerran, Macia, Erasmus, Rajiv T, Erbel, Raimund, Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Pena, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Faeh, David, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Sant'Angelo, Victoria Farrugia, Farzadfar, Farshad, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernandez-Berges, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferrer, Eldridge, Ferrieres, Jean, Figueiro, Thamara Hubler, Fijalkowska, Anna, Fink, Gunther, Fischer, Krista, Foger, Bernhard, Foo, Leng Huat, Forsner, Maria, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Franco, Oscar H, Frikke-Schmidt, Ruth, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujiati, Isti I, Fujita, Yuki, Fumihiko, Matsuda, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Galbarczyk, Andrzej, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Garcia-de-la-Hera, Manoli, Garcia-Solano, Marta, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gaya, Adroaldo Cesar Araujo, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K, Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Godos, Justyna, Gogen, Sibel, Goldsmith, Rebecca A, Goltzman, David, Gomez, Santiago F, Gomula, Aleksandra, da Silva, Bruna Goncalves Cordeiro, Goncalves, Helen, Gonzalez-Chica, David A, Gonzalez-Gross, Marcela, Gonzalez-Leon, Margot, Gonzalez-Rivas, Juan P, Gonzalez-Villalpando, Clicerio, Gonzalez-Villalpando, Maria-Elena, Gonzalez, Angel R, Gottrand, Frederic, Graca, Antonio Pedro, Graff-Iversen, Sidsel, Grafnetter, Dusan, Grajda, Aneta, Grammatikopoulou, Maria G, Gregor, Ronald D, Grodzicki, Tomasz, Groholt, Else Karin, Grontved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Gualdi-Russo, Emanuela, Guallar-Castillon, Pilar, Gualtieri, Andrea, Gudmundsson, Elias F, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L, Gulliford, Martin C, Gunnlaugsdottir, Johanna, Gunter, Marc J, Guo, Xiu-Hua, Guo, Yin, Gupta, Prakash C, Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez-Gonzalez, Enrique, Gutierrez, Laura, Gutzwiller, Felix, Ha, Seongjun, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A, Haghshenas, Rosa, Hakimi, Hamid, Halkjaer, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Kumar, Rachakulla Hari, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Hayes, Alison J, He, Jiang, He, Yuan, He, Yuna, Heidinger-Felso, Regina, Heinen, Mirjam, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Cadena, Leticia Hernandez, Herrala, Sauli, Herrera, Victor M, Herter-Aeberli, Isabelle, Heshmat, Ramin, Hill, Allan G, Ho, Sai Yin, Ho, Suzanne C, Hobbs, Michael, Hofman, Albert, Bergh, Ingunn Holden, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hopman, Wilma M, Horimoto, Andrea RVR, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Thein, Thein Htay, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Huerta, Jose Maria, Huhtaniemi, Ilpo Tapani, Petrescu, Constanta Huidumac, Husseini, Abdullatif, Chinh, Nguyen Huu, Huybrechts, Inge, Hwalla, Nahla, Hyska, Jolanda, Iacoviello, Licia, Ibarluzea, Jesus M, Ibrahim, Mohsen M, Wong, Norazizah Ibrahim, Ikeda, Nayu, Ikram, M Arfan, Iotova, Violeta, Irazola, Vilma E, Ishida, Takafumi, Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Iwasaki, Masanori, Jackson, Rod T, Jacobs, Jeremy M, Jaddou, Hashem Y, Jafar, Tazeen, James, Kenneth, Jamil, Kazi M, Jamrozik, Konrad, Janszky, Imre, Janus, Edward, Jarani, Juel, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelakovic, Ana, Jelakovic, Bojan, Jennings, Garry, Jha, Anjani Kumar, Jiang, Chao Qiang, Jimenez, Ramon O, Jockel, Karl-Heinz, Joffres, Michel, Johansson, Mattias, Jokelainen, Jari J, Jonas, Jost B, Jorgensen, Torben, Joshi, Pradeep, Joukar, Farahnaz, Jovic, Dragana P, Jozwiak, Jacek J, Juolevi, Anne, Jurak, Gregor, Simina, Iulia Jurca, Juresa, Vesna, Kaaks, Rudolf, Kaducu, Felix O, Kafatos, Anthony, Kajantie, Eero O, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kameli, Yves, Kanala, Kodanda R, Kannan, Srinivasan, Kapantais, Efthymios, Karki, Khem B, Katibeh, Marzieh, Katz, Joanne, Katzmarzyk, Peter T, Kauhanen, Jussi, Kaur, Prabhdeep, Kavousi, Maryam, Kazakbaeva, Gyulli M, Keil, Ulrich, Boker, Lital Keinan, Keinanen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han CG, Keramati, Maryam, Kerimkulova, Alina, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khaw, Kay-Tee, Kheiri, Bahareh, Kheradmand, Motahareh, Khosravi, Alireza, Khouw, Ilse MSL, Kiechl-Kohlendorfer, Ursula, Kiechl, Stefan, Killewo, Japhet, Kim, Dong Wook, Kim, Hyeon Chang, Kim, Jeongseon, Kindblom, Jenny M, Klakk, Heidi, Klimek, Magdalena, Klimont, Jeannette, Klumbiene, Jurate, Knoflach, Michael, Koirala, Bhawesh, Kolle, Elin, Kolsteren, Patrick, Konig, Jurgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Kos, Jelena, Koskinen, Seppo, Kouda, Katsuyasu, Kovacs, Viktoria A, Kowlessur, Sudhir, Koziel, Slawomir, Kratzer, Wolfgang, Kriemler, Susi, Kristensen, Peter Lund, Krokstad, Steiner, Kromhout, Daan, Krtalic, Branimir, Kruger, Herculina S, Kubinova, Ruzena, Kuciene, Renata, Kujala, Urho M, Kujundzic, Enisa, Kulaga, Zbigniew, Kumar, R Krishna, Kunesova, Marie, Kurjata, Pawel, Kusuma, Yadlapalli S, Kuulasmaa, Kari, Kyobutungi, Catherine, Quang, Ngoc La, Laamiri, Fatima Zahra, Laatikainen, Tiina, Lachat, Carl, Laid, Youcef, Lam, Tai Hing, Lambrinou, Christina-Paulina, Landais, Edwige, Lanska, Vera, 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Ferrario MM, Ferreccio C, Ferrer E, Ferrieres J, Figueiró TH, Fijalkowska A, Fink G, Fischer K, Föger B, Foo LH, Forsner M, Fouad HM, Francis DK, Franco MDC, Franco OH, Frikke-Schmidt R, Frontera G, Fuchs FD, Fuchs SC, Fujiati II, Fujita Y, Fumihiko M, Furusawa T, Gaciong Z, Gafencu M, Galbarczyk A, Galenkamp H, Galeone D, Galfo M, Galvano F, Gao J, Garcia-de-la-Hera M, García-Solano M, Gareta D, Garnett SP, Gaspoz J-M, Gasull M, Gaya ACA, Gaya AR, Gazzinelli A, Gehring U, Geiger H, Geleijnse JM, Ghanbari A, Ghasemi E, Gheorghe-Fronea O-F, Giampaoli S, Gianfagna F, Gill TK, Giovannelli J, Gironella G, Giwercman A, Gkiouras K, Godos J, Gogen S, Goldsmith RA, Goltzman D, Gómez SF, Gomula A, Goncalves Cordeiro da Silva B, Gonçalves H, Gonzalez-Chica DA, Gonzalez-Gross M, González-Leon M, González-Rivas JP, González-Villalpando C, González-Villalpando M-E, Gonzalez AR, Gottrand F, Graça AP, Graff-Iversen S, Grafnetter D, Grajda A, Grammatikopoulou MG, Gregor RD, Grodzicki T, Grøholt EK, 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Nordestgaard B.G., Noto D., Nowak-Szczepanska N., Nsour M.A., Nuhoglu I., Nurk E., O'Neill T.W., O'Reilly D., Obreja G., Ochimana C., Ochoa-Aviles A.M., Oda E., Oh K., Ohara K., Ohlsson C., Ohtsuka R., Olafsson O., Olinto M.T.A., Oliveira I.O., Omar M.A., Onat A., Ong S.K., Ono L.M., Ordunez P., Ornelas R., Ortiz A.P., Ortiz P.J., Osler M., Osmond C., Ostojic S.M., Ostovar A., Otero J.A., Overvad K., Owusu-Dabo E., Paccaud F.M., Padez C., Pagkalos I., Pahomova E., Paiva K.M.D., Pajak A., Palli D., Palloni A., Palmieri L., Pan W.-H., Panda-Jonas S., Pandey A., Panza F., Papandreou D., Park S.-W., Park S., Parnell W.R., Parsaeian M., Pascanu I.M., Pasquet P., Patel N.D., Pednekar M.S., Peer N., Peixoto S.V., Peltonen M., Pereira A.C., Peres M.A., Perez-Farinos N., Perez C.M., Peterkova V., Peters A., Petersmann A., Petkeviciene J., Petrauskiene A., Pettenuzzo E., Peykari N., Pham S.T., Pichardo R.N., Pierannunzio D., Pigeot I., Pikhart H., Pilav A., Pilotto L., Pistelli F., Pitakaka F., 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Subjects
Male, body-mass index, ADULTHOOD, Adolescents, pituuskasvu, Pediatrics, Body Mass Index, 0302 clinical medicine, Child Development, nuoret, Public health surveillance, Medicine, Health Status Indicators, 10. No inequality, Child, 11 Medical and Health Sciences, Body mass index, ComputingMilieux_MISCELLANEOUS, education.field_of_study, VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801, General Medicine, Body mass indexes, kansainvälinen vertailu, 3. Good health, Geography, Health, 030220 oncology & carcinogenesis, Child, Preschool, Medical and Health sciences, purl.org/becyt/ford/3 [https], medicine.medical_specialty, School-aged adolescents, Socio-culturale, lapset (ikäryhmät), Nursing, territories, ravinto, purl.org/becyt/ford/3.3 [https], 03 medical and health sciences, School Children, SDG 3 - Good Health and Well-being, SYSTEMATIC ANALYSIS, Humans, school-aged children and adolescents, Montenegro, education, Science & Technology, Omvårdnad, Health sciences, Medical and Health sciences, Ciências médicas e da saúde, Bayes Theorem, Anthropometry, Adolescent Development, medicine.disease, TRENDS, Height and Body-mass Index, Faculdade de Ciências Sociais, UNDERNUTRITION, Height index trajectories, Height, body mass index, children , epidemiology, risk factors, growth, Stature, Demography, Settore MED/09 - Medicina Interna, Internationality, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Body-mass index trajectories, Epidemiology, Medicine and Health Sciences, risk factors, countries, EPIDEMIOLOGY, height, children, adolescents, BMI, 030212 general & internal medicine, painoindeksi, Child development, 2. Zero hunger, Medicine(all), School age child, obestity children cardiovascular, Population Health, 1. No poverty, Pediatrik, Public Health, Global Health, Social Medicine and Epidemiology, 3142 Public health care science, environmental and occupational health, Pooled analysis, NUTRITION, Female, medicine.symptom, pooled analysis, Life Sciences & Biomedicine, terveys, height, BMI, nutrition, health, children, adolescents, Adolescent, growth, Population, body-mass, Population based, Body-mass index, Young Adult, Medicine, General & Internal, Meta-Analysis as Topic, General & Internal Medicine, parasitic diseases, Weight gain, School-aged childrens, Age trajectories, business.industry, Height, Weight, Body Height, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Malnutrition, ONSET, Ciências da Saúde, Ciências médicas e da saúde, School-aged children, VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801, business, terveysriskit, Estilos de Vida e Impacto na Saúde
Abstract

BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents., METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence., FINDINGS: We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls., INTERPRETATION: The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks., Wellcome Trust, AstraZeneca Young Health Programme, EU., peer-reviewed

Published
2020

384. Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Author

Bixby, Honor, Bentham, James, Zhou, Bin, Di Cesare, Mariachiara, Paciorek, Christopher J., Bennett, James E., Taddei, Cristina, Stevens, Gretchen A., Rodriguez-Martinez, Andrea, Carrillo-Larco, Rodrigo M., Khang, Young-Ho, Soric, Maroje, Gregg, Edward W., Miranda, J. Jaime, Bhutta, Zulfiqar A., Savin, Stefan, Sophiea, Marisa K., Iurilli, Maria L. C., Solomon, Bethlehem D., Cowan, Melanie J., Riley, Leanne M., Danaei, Goodarz, Bovet, Pascal, Chirita-Emandi, Adela, Hambleton, Ian R., Hayes, Alison J., Ikeda, Nayu, Kengne, Andre P., Laxmaiah, Avula, Li, Yanping, McGarvey, Stephen T., Mostafa, Aya, Neovius, Martin, Starc, Gregor, Zainuddin, Ahmad A., Abarca-Gomez, Leandra, Abdeen, Ziad A., Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Hamid, Zargar Abdul, Garba, Jamila Abubakar, Abu-Rmeileh, Niveen M., Acosta-Cazares, Benjamin, Adams, Robert J., Aekplakorn, Wichai, Afsana, Kaosar, Agdeppa, Imelda A., Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Naser, Ahmadvand, Alireza, Ahrens, Wolfgang, Ajlouni, Kamel, AlBuhairan, Fadia, AlDhukair, Shahla, Al-Hazzaa, Hazzaa M., Ali, Mohamed M., Ali, Osman, Alkerwi, Ala'a, Al-Othman, Amani Rashed, Al-Raddadi, Rajaa, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N., Amouyel, Philippe, Amuzu, Antoinette, Bo, Lars, Anderssen, Sigmund A., Angquist, Lars H., Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araujo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E., Arlappa, Nimmathota, Aryal, Krishna K., Aspelund, Thor, Assah, Felix K., Assuncao, Maria Cecilia F., Aung, May Soe, Auvinen, Juha, Avdicova, Maria, Azevedo, Ana, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha V., Baharudin, Azli, Bahijri, Suhad, Baker, Jennifer L., Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, Jose R., Barbagallo, Carlo M., Barcelo, Alberto, Barkat, Amina, Barros, Aluisio J. D., Barros, Mauro V. G., Bata, Iqbal, Batieha, Anwar M., Batista, Rosangela L., Battakova, Zhamilya, Batyrbek, Assembekov, Baur, Louise A., Beaglehole, Robert, Bel-Serrat, Silvia, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bi, Hongsheng, Bi, Yufang, Biehl, Anna, Lele, Elysee Claude Bika, Bikbov, Mukharram, Bista, Bihungum, Bjelica, Dusko J., Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Bjorkelund, Cecilia, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M., Boehm, Bernhard O., Boeing, Heiner, Boggia, Jose G., Boissonnet, Carlos P., Bonaccio, Marialaura, Bongard, Vanina, Bopp, Matthias, Borchini, Rossana, Borghs, Herman, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn C. E., Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, Joao, Brenner, Hermann, Brewster, Lizzy M., Brian, Garry R., Brinduse, Lacramioara, Bruno, Graziella, Bueno-de-Mesquita, H. Bas, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de Leon, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gamze, Can, Gunay, Candido, Ana Paula C., Canete, Felicia, Capanzana, Mario V., Capuano, Eduardo, Capuano, Vincenzo, Cardoso, Viviane C., Carlsson, Axel C., Carmuega, Esteban, Carvalho, Maria J., Casanueva, Felipe F., Casas, Juan-Pablo, Caserta, Carmelo A., Celikcan, Ertugrul, Censi, Laura, Cesar, Juraci A., Chamukuttan, Snehalatha, Chan, Angelique W., Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nishi, Rahim, Norsyamlina Che Abdul, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheng, Yiling J., Chetrit, Angela, Chikova-Iscener, Ekaterina, Chiolero, Arnaud, Chiou, Shu-Ti, Chirlaque, Maria-Dolores, Cho, Belong, Cho, Yumi, Christensen, Kaare, Christofaro, Diego G., Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Claessens, Frank, Clarke, Janine, Clays, Els, Concin, Hans, Confortin, Susana C., Cooper, Cyrus, Coppinger, Tara C., Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crampin, Amelia C., Crujeiras, Ana B., Cruz, Juan J., Cucu, Alexandra, Cui, Liufu, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T., Dankner, Rachel, Dantoft, Thomas M., D'Arrigo, Graziella, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, De Curtis, Amalia, de Gaetano, Giovanni, De Henauw, Stefaan, de Oliveira, Paula Duarte, De Ridder, Karin, de Rooij, Susanne R., De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D., Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Dennison, Elaine, Deschamps, Valerie, Dhana, Klodian, Dhimal, Meghnath, Di Castelnuovo, Augusto F., Dias-da-Costa, Juvenal Soares, Diaz, Alejandro, Dika, Zivka, Djalalinia, Shirin, Do, Ha T. P., Dobson, Annette J., Donati, Maria Benedetta, Donfrancesco, Chiara, Donoso, Silvana P., Doering, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, d'Orsi, Eleonora, Doua, Kouamelan, Drygas, Wojciech, Duan, Jia Li, Duante, Charmaine A., Duda, Rosemary B., Duleva, Vesselka, Dulskiene, Virginija, Dumith, Samuel C., Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Eddie, Ricky, Egbagbe, Eruke E., Eggertsen, Robert, Eiben, Gabriele, Ekelund, Ulf, El Ati, Jalila, Eldemire-Shearer, Denise, Eliasen, Marie, Elliott, Paul, Engle-Stone, Reina, Erasmus, Rajiv T., Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G., Escobedo-de la Pena, Jorge, Evans, Alun, Faeh, David, Fall, Caroline H., Sant'Angelo, Victoria Farrugia, Farzadfar, Farshad, Fattahi, Mohammad R., Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernandes, Romulo A., Fernandez-Berges, Daniel, Ferrante, Daniel, Ferrari, Marika, Ferreccio, Catterina, Ferrer, Eldridge, Ferrieres, Jean, Fijalkowska, Anna, Fink, Gunther, Fischer, Krista, Flores, Eric Monterubio, Foeger, Bernhard, Foo, Leng Huat, Forslund, Ann-Sofie, Forsner, Maria, Fouad, Heba M., Francis, Damian K., Franco, Maria do Carmo, Franco, Oscar H., Frontera-Juan, Guillem, Fuchs, Flavio D., Fuchs, Sandra C., Fujita, Yuki, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Galeone, Daniela, Galvano, Fabio, Gao, Jingli, Garcia-de-la-Hera, Manoli, Gareta, Dickman, Garnett, Sarah P., Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Gazzinelli, Andrea, Geiger, Harald, Geleijnse, Johanna M., Ghanbari, Ali, Ghasemi, Erfan, Ghasemian, Anoosheh, Gheorghe-Fronea, Oana-Florentina, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K., Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Godos, Justyna, Gogen, Sibel, Goldsmith, Rebecca A., Goltzman, David, Goncalves, Helen, Gonzalez, Angel R., Gonzalez-Chica, David A., Gonzalez-Gross, Marcela, Gonzalez-Leon, Margot, Gonzalez-Rivas, Juan P., Gonzalez-Villalpando, Maria-Elena, Gottrand, Frederic, Graca, Antonio Pedro, Graff-Iversen, Sidsel, Grafnetter, Dusan, Grajda, Aneta, Grammatikopoulou, Maria G., Gregor, Ronald D., Grodzicki, Tomasz, Grontved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Gualdi-Russo, Emanuela, Gudmundsson, Elias F., Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L., Gulliford, Martin C., Gunnlaugsdottir, Johanna, Gunter, Marc, Guo, Xiuhua, Guo, Yin, Gupta, Prakash C., Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez, Laura, Gutzwiller, Felix, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A., Haghshenas, Rosa, Halkjaer, Jytte, Hardy, Rebecca, Kumar, Rachakulla Hari, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, He, Jiang, He, Yuna, Heidinger-Felso, Regina, Heinen, Mirjam, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, Henriques, Ana, Hernandez Cadena, Leticia, Herrala, Sauli, Herrera, Victor M., Herter-Aeberli, Isabelle, Heshmat, Ramin, Hill, Allan G., Ho, Sai Yin, Ho, Suzanne C., Hobbs, Michael, Hofman, Albert, Hopman, Wilma M., Horimoto, Andrea R. V. R., Hormiga, Claudia M., Horta, Bernardo L., Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Huerta, Jose Maria, Huhtaniemi, Ilpo Tapani, Petrescu, Constanta Huidumac, Huisman, Martijn, Husseini, Abdullatif, Chinh Nguyen Huu, Huybrechts, Inge, Hwalla, Nahla, Hyska, Jolanda, Iacoviello, Licia, Ibarluzea, Jesus M., Ibrahim, Mohsen M., Wong, Norazizah Ibrahim, Ikram, M. Arfan, Irazola, Vilma E., Ishida, Takafumi, Islam, Muhammad, Ismail, Aziz al-Safi, Ivkovic, Vanja, Iwasaki, Masanori, Jaaskelainen, Tuija, Jackson, Rod T., Jacobs, Jeremy M., Jaddou, Hashem, Jafar, Tazeen, James, Kenneth, Jamil, Kazi M., Jamrozik, Konrad, Janszky, Imre, Janus, Edward, Jarani, Juel, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelakovic, Ana, Jelakovic, Bojan, Jennings, Garry, Jeong, Seung-Lyeal, Jiang, Chao Qiang, Jimenez, Ramon O., Joffres, Michel, Johansson, Mattias, Jokelainen, Jari J., Jonas, Jost B., Jorgensen, Torben, Joshi, Pradeep, Jovic, Dragana P., Jozwiak, Jacek, Juolevi, Anne, Jurak, Gregor, Juresa, Vesna, Kaaks, Rudolf, Kafatos, Anthony, Kajantie, Eero O., Kalter-Leibovici, Ofra, Kamaruddin, Nor Azmi, Kameli, Yves, Kapantais, Efthymios, Karki, Khem B., Kasaeian, Amir, Katibeh, Marzieh, Katz, Joanne, Katzmarzyk, Peter T., Kauhanen, Jussi, Kaur, Prabhdeep, Kavousi, Maryam, Kazakbaeva, Gyulli, Keil, Ulrich, Keinan-Boker, Lital, Keinanen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han C. G., Kerimkulova, Alina, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khateeb, Mohammad, Khaw, Kay-Tee, Kheiri, Bahareh, Khosravi, Alireza, Khouw, Ilse M. S. L., Kiechl, Stefan, Kiechl-Kohlendorfer, Ursula, Killewo, Japhet, Kim, Jeongseon, Kim, Yeon-Yong, Klimont, Jeannette, Klumbiene, Jurate, Knoflach, Michael, Koirala, Bhawesh, Kolle, Elin, Kolsteren, Patrick, Koenig, Jurgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Koskinen, Seppo, Kouda, Katsuyasu, Kovacs, Viktoria A., Kowlessur, Sudhir, Koziel, Slawomir, Kratzer, Wolfgang, Kriemler, Susi, Kristensen, Peter Lund, Krokstad, Steinar, Kromhout, Daan, Kruger, Herculina S., Kubinova, Ruzena, Kuciene, Renata, Kuh, Diana, Kujala, Urho M., Kujundzic, Enisa, Kulaga, Zbigniew, Kumar, R. Krishna, Kunesova, Marie, Kurjata, Pawel, Kusuma, Yadlapalli S., Kuulasmaa, Kari, Kyobutungi, Catherine, Quang Ngoc La, Laamiri, Fatima Zahra, Laatikainen, Tiina, Lachat, Carl, Laid, Youcef, Tai Hing Lam, Morovic, Maja Lang, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Latt, Tint Swe, Laugsand, Lars E., Lauria, Laura, Lazo-Porras, Maria, Khanh Le Nguyen Bao, Le Port, Agnes, Le, Tuyen D., Lee, Jeannette, Lee, Jeonghee, Lee, Paul H., Lehtimaki, Terho, Lemogoum, Daniel, Levitt, Naomi S., Lilly, Christa L., Lim, Wei-Yen, Lima-Costa, M. Fernanda, Lin, Hsien-Ho, Lin, Xu, Lind, Lars, Linneberg, Allan, Lissner, Lauren, Litwin, Mieczyslaw, Liu, Jing, Loit, Helle-Mai, Lopes, Luis, Lopez, Tania, Lopez-Garcia, Esther, Lorbeer, Roberto, Lotufo, Paulo A., Lozano, Jose Eugenio, Luksiene, Dalia, Lundqvist, Annamari, Lundqvist, Robert, Lunet, Nuno, Lytsy, Per, Ma, Guansheng, Ma, Jun, Machado-Coelho, George L. L., Machado-Rodrigues, Aristides M., Machi, Suka, Maggi, Stefania, Magliano, Dianna J., Magriplis, Emmanuella, Maire, Bernard, Majer, Marjeta, Makdisse, Marcia, Malekzadeh, Fatemeh, Malekzadeh, Reza, Malhotra, Rahul, Malyutina, Sofia, Maniego, Lynell V., Manios, Yannis, Mann, Jim I., Manzato, Enzo, Margozzini, Paula, Markaki, Anastasia, Markey, Oonagh, Ioannidou, Eliza Markidou, Marques, Larissa Pruner, Marques-Vidal, Pedro, Marrugat, Jaume, Martin, Rosemarie, Martin-Prevel, Yves, Martorell, Reynaldo, Martos, Eva, Marventano, Stefano, Masoodi, Shariq R., Mathiesen, Ellisiv B., Mathur, Prashant, Matijasevich, Alicia, Matsha, Tandi E., Mazur, Artur, Mbanya, Jean Claude N., McFarlane, Shelly R., Mckee, Martin, McLachlan, Stela, McLean, Rachael M., McLean, Scott B., McNulty, Breige A., Yusof, Safiah Md, Mediene-Benchekor, Sounnia, Medzioniene, Jurate, Mehdipour, Parinaz, Meirhaeghe, Aline, Meisfjord, Jorgen, Meisinger, Christa, Menezes, Ana Maria B., Menon, Geetha R., Mensink, Gert B. M., Mereke, Alibek, Meshram, Indrapal I., Metspalu, Andres, Meyer, Haakon E., Mi, Jie, Michaelsen, Kim F., Michels, Nathalie, Mikkel, Kairit, Miller, Jody C., Minderico, Claudia S., Francisco Miquel, Juan, Mirkopoulou, Daphne, Mirrakhimov, Erkin, Misigoj-Durakovic, Marjeta, Mistretta, Antonio, Mocanu, Veronica, Modesti, Pietro A., Moghaddam, Sahar Saeeidi, Mohajer, Bahram, Mohamed, Mostafa K., Mohammad, Kazem, Mohammadifard, Noushin, Mohan, Viswanathan, Mohanna, Salim, Yusoff, Muhammad Fadhli Mohd, Mohebi, Farnam, Moitry, Marie, Molbo, Drude, Mollehave, Line T., Moller, Niels C., Molnar, Denes, Momenan, Amirabbas, Mondo, Charles K., Monterrubio, Eric A., Monyeki, Kotsedi Daniel K., Moon, Jin Soo, Moreira, Leila B., Morejon, Alain, Moreno, Luis A., Morgan, Karen, Morin, Suzanne, Mortensen, Erik Lykke, Moschonis, George, Mossakowska, Malgorzata, Mota, Jorge, Mota-Pinto, Anabela, Motlagh, Mohammad Esmaeel, Motta, Jorge, Msyamboza, Kelias P., Mu, Thet Thet, Muc, Magdalena, Mugosa, Boban, Muiesan, Maria Lorenza, Mukhtorova, Parvina, Mueller-Nurasyid, Martina, Murphy, Neil, Mursu, Jaakko, Murtagh, Elaine M., Milanovic, Sanja Music, Musil, Vera, Nabipour, Iraj, Naderimagham, Shohreh, Nagel, Gabriele, Naidu, Balkish M., Nakamura, Harunobu, Namesna, Jana, Nang, Ei Ei K., Nangia, Vinay B., Nankap, Martin, Narake, Sameer, Nardone, Paola, Nauck, Matthias, Navarrete-Munoz, Eva Maria, Neal, William A., Nelis, Keiu, Nelis, Liis, Nenko, Ilona, Nervi, Flavio, Nguyen, Chung T., Nguyen, Nguyen D., Quang Ngoc Nguyen, Nieto-Martinez, Ramfis E., Ning, Guang, Ninomiya, Toshiharu, Nishtar, Sania, Noale, Marianna, Noboa, Oscar A., Norat, Teresa, Norie, Sawada, Noto, Davide, Al Nsour, Mohannad, Nurk, Eha, Nyirenda, Moffat, Obreja, Galina, Ochoa-Aviles, Angelica M., Oda, Eiji, Oh, Kyungwon, Ohara, Kumiko, Ohtsuka, Ryutaro, Olafsson, Orn, Anselmo Olinto, Maria Teresa, Oliveira, Isabel O., Oltarzewski, Maciej, Omar, Mohd Azahadi, Onat, Altan, O'Neill, Terence W., Ong, Sok King, Ono, Lariane M., Ordunez, Pedro, O'Reilly, Dermot, Ornelas, Rui, Ortiz, Ana P., Ortiz, Pedro J., Osler, Merete, Osmond, Clive, Ostojic, Sergej M., Ostovar, Afshin, Otero, Johanna A., Overvad, Kim, Owusu-Dabo, Ellis, Paccaud, Fred Michel, Padez, Cristina, Pagkalos, Ioannis, Pahomova, Elena, Pajak, Andrzej, Palli, Domenico, Palloni, Alberto, Palmieri, Luigi, Pan, Wen-Harn, Panda-Jonas, Songhomitra, Pandey, Arvind, Panza, Francesco, Papandreou, Dimitrios, Park, Soon-Woo, Parnell, Winsome R., Parsaeian, Mahboubeh, Pascanu, Ionela M., Patel, Nikhil D., Pecin, Ivan, Pednekar, Mangesh S., Peer, Nasheeta, Peixoto, Sergio Viana, Peltonen, Markku, Pereira, Alexandre C., Perez, Cynthia M., Perez-Farinos, Napoleon, Peters, Annette, Petersmann, Astrid, Petkeviciene, Janina, Petrauskiene, Ausra, Peykari, Niloofar, Son Thai Pham, Pierannunzio, Daniela, Pigeot, Iris, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pistelli, Francesco, Pitakaka, Freda, Piwonska, Aleksandra, Plans-Rubio, Pedro, Poh, Bee Koon, Pohlabeln, Hermann, Pop, Raluca M., Popovic, Stevo R., Porta, Miquel, Portegies, Marileen L. P., Posch, Georg, Poulimeneas, Dimitrios, Pouraram, Hamed, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Price, Alison J., Price, Jacqueline F., Puder, Jardena J., Pudule, Iveta, Puhakka, Soile E., Puiu, Maria, Punab, Margus, Qasrawi, Radwan F., Qorbani, Mostafa, Tran Quoc Bao, Radhika, Madhari S., Radic, Ivana, Radisauskas, Ricardas, Rahman, Mahfuzar, Rahman, Mahmudur, Raitakari, Olli, Raj, Manu, Rajkumar, Hemalatha, Rakhmatulloev, Sherali, Rao, Sudha Ramachandra, Ramachandran, Ambady, Ramke, Jacqueline, Ramos, Elisabete, Ramos, Rafel, Rampal, Lekhraj, Rampal, Sanjay, Rao, Kodavanti Mallikharjuna, Rascon-Pacheco, Ramon A., Rasmussen, Mette, Redon, Josep, Reganit, Paul Ferdinand M., Regecova, Valeria, Revilla, Luis, Ribas-Barba, Lourdes, Ribeiro, Robespierre, Riboli, Elio, Rigo, Fernando, Rinaldo, Natascia, de Wit, Tobias F. 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R., Rubinstein, Adolfo, Ruhli, Frank J., Ruidavets, Jean-Bernard, Ruiz Moreno, Emma, Sandra Ruiz-Betancourt, Blanca, Russo, Paola, Rust, Petra, Rutkowski, Marcin, Sabanayagam, Charumathi, Sachdev, Harshpal S., Safiri, Saeid, Saidi, Olfa, Salanave, Benoit, Salazar-Martinez, Eduardo, Salmeron, Diego, Salomaa, Veikko, Salonen, Jukka T., Salvetti, Massimo, Sanchez-Abanto, Jose, Sandjaja, Sans, Susana, Santa-Marina, Loreto, Santos, Diana A., Santos, Ina S., Santos, Osvaldo, Santos, Rute, Santos Sanz, Sara, Saramies, Jouko L., Sardinha, Luis B., Sarrafzadegan, Nizal, Saum, Kai-Uwe, Savva, Savvas, Savy, Mathilde, Scazufca, Marcia, Rosario, Angelika Schaffrath, Schargrodsky, Herman, Schienkiewitz, Anja, Schindler, Karin, Schipf, Sabine, Schmidt, Carsten O., Schmidt, Ida Maria, Schoettker, Ben, Schultsz, Constance, Schutte, Aletta E., Sebert, Sylvain, Sein, Aye Aye, Selamat, Rusidah, Sember, Vedrana, Sen, Abhijit, Senbanjo, Idowu O., Sepanlou, Sadaf G., Sequera, Victor, Serra-Majem, Luis, Servais, Jennifer, Shalnova, Svetlana A., Sharma, Sanjib K., Shaw, Jonathan E., Shengelia, Lela, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shin, Dong Wook, Shin, Youchan, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M., Silva, Antonio M., Santos Silva, Diego Augusto, Simon, Mary, Simons, Judith, Simons, Leon A., Si-Ramlee, Khairil, Sjoberg, Agneta, Sjostrom, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, Snijder, Marieke B., So, Hung-Kwan, Sobngwi, Eugene, Soderberg, Stefan, Soekatri, Moesijanti Y. E., Soemantri, Agustinus, Solfrizzi, Vincenzo, Sonestedt, Emily, Song, Yi, Sorensen, Thorkild I. A., Jerome, Charles Sossa, Soumare, Aicha, Spinelli, Angela, Spiroski, Igor, Staessen, Jan A., Stamm, Hanspeter, Stathopoulou, Maria G., Staub, Kaspar, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D., Stergiou, George S., Stessman, Jochanan, Stoeckl, Doris, Stocks, Tanja, Stokwiszewski, Jakub, Stratton, Gareth, Stronks, Karien, Strufaldi, Maria Wany, Sturua, Lela, Suarez-Medina, Ramon, Sun, Chien-An, Sundstrom, Johan, Sung, Yn-Tz, Sunyer, Jordi, Suriyawongpaisal, Paibul, Swinburn, Boyd A., Sy, Rody G., Sylva, Rene Charles, Szponar, Lucjan, Tai, E. Shyong, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tan, Eng Joo, Tang, Xun, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B., Braunerova, Radka Taxova, Taylor, Anne, Tchibindat, Felicite, Tebar, William R., Tell, Grethe, Tello, Tania, Theobald, Holger, Theodoridis, Xenophon, Thijs, Lutgarde, Thuesen, Betina H., Ticha, Lubica, Timmermans, Erik J., Tjonneland, Anne, Tolonen, Hanna K., Tolstrup, Janne S., Topbas, Murat, Topor-Madry, Roman, Tormo, Maria Jose, Tornaritis, Michael J., Torrent, Maties, Toselli, Stefania, Traissac, Pierre, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh T. H., Trivedi, Atul, Tsao, Yu-Hsiang, Tshepo, Lechaba, Tsigga, Maria, Tsugane, Shoichiro, Tulloch-Reid, Marshall K., Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Turley, Maria L., Tynelius, Per, Tzotzas, Themistoklis, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice E., Ukoli, Flora A. M., Ulmer, Hanno, Unal, Belgin, Uusitalo, Hannu M. 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Woodward M., Wu F.C., Wu J., Wu S., Xu H., Xu L., Yamborisut U., Yan W., Yang L., Yang X., Yang Y., Yardim N., Yaseri M., Ye X., Yiallouros P.K., Yngve A., Yoosefi M., Yoshihara A., You Q.S., You S.-L., Younger-Coleman N.O., Yusoff A.F., Zaccagni L., Zafiropulos V., Zamani F., Zambon S., Zampelas A., Zamrazilova H., Zapata M.E., Zaw K.K., Zdrojewski T., ZeljkovicVrkic T., Zeng Y., Zhao D., Zhao W., Zheng W., Zheng Y., Zholdin B., Zhou M., Zhu D., Zhussupov B., Zimmermann E., ZunigaCisneros J., Ezzati M., Bixby H, Bentham J, Zhou B, Di Cesare M, Paciorek CJ, Bennett JE, Taddei C, Stevens GA, Rodriguez-Martinez A, Carrillo-Larco RM, Khang Y-H, Sorić M, Gregg EW, Miranda JJ, Bhutta ZA, Savin S, Sophiea MK, Iurilli MLC, Solomon BD, Cowan MJ, Riley LM, Danaei G, Bovet P, Chirita-Emandi A, Hambleton IR, Hayes AJ, Ikeda N, Kengne AP, Laxmaiah A, Li Y, McGarvey ST, Mostafa A, Neovius M, Starc G, Zainuddin AA, Abarca-Gómez L, Abdeen ZA, Abdrakhmanova S, Abdul Ghaffar S, Abdul Hamid Z, Abubakar 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H, Zapata ME, Zaw KK, Zdrojewski T, Zeljkovic Vrkic T, Zeng Y, Zhao D, Zhao W, Zheng W, Zheng Y, Zholdin B, Zhou M, Zhu D, Zhussupov B, Zimmermann E, Zuñiga Cisneros J, Ezzati M, Yiallouros, Panayiotis K. [0000-0002-8339-9285], APH - Societal Participation & Health, APH - Aging & Later Life, Epidemiology and Data Science, Public and occupational health, APH - Health Behaviors & Chronic Diseases, and APH - Personalized Medicine

Subjects
Male, Rural Population, obesity, Obesity, body mass index, Settore MED/09 - Medicina Interna, Letter, Urban Population, Epidemiology, [SDV]Life Sciences [q-bio], humanos, body-mass index, adolescente, Geographic Mapping, Sex Factor, países desarrollados, Rural Health, purl.org/pe-repo/ocde/ford#3.03.09 [https], systematic analysis, Body Mass Index, países en desarrollo, 80 and over, risk factors, Age Factor, physical-activity, mediana edad, mapeo geográfico, Aged, 80 and over, anciano, purl.org/pe-repo/ocde/ford#3.02.18 [https], dieta, Age Factors, health, adulto, Middle Aged, Multidisciplinary Sciences, adulto joven, [SDV] Life Sciences [q-bio], estado nutricional, nutrition, Science & Technology - Other Topics, NUTRITION, Female, HEALTH, pooled analysis, Diet, Healthy, worldwide trends, Human, Developed Countrie, Adult, Adolescent, purl.org/pe-repo/ocde/ford#3.03.04 [https], FOOD SYSTEM, Socio-culturale, Nutritional Status, URBAN, Aged, Developed Countries, Developing Countries, Humans, Obesity, Sex Factors, Urban Health, Young Adult, POOLED ANALYSIS, Developing Countrie, MIDDLE-INCOME COUNTRIES, SYSTEMATIC ANALYSIS, Urban rural Obesity Body-Mass-Index, obesidad, Middle-income countries, food system, urban, weight, Healthy, Science & Technology, índice de masa corporal, Diet, PHYSICAL-ACTIVITY, WORLDWIDE TRENDS, Risk factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, WEIGHT
Abstract

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories., This study was funded by the Wellcome Trust. H.B. was supported by a Medical Research Council Doctoral Training Partnership Studentship, J.B. by a Royal Society Research Grant, and M.D.C. by an Academy of Medical Sciences Springboard Award. We thank L. Jaacks, B. Popkin, S. Sundberg and W. Willett for recommendations of relevant citations. The authors are responsible for the views expressed in this Letter and they do not necessarily represent the views, decisions, or policies of the institutions with which they are affiliated.

Published
2019

385. Measuring nutritional knowledge using Item Response Theory and its validity in European adolescents

Author

Souza Santos, Thanise Sabrina, Julian, Cristina, de Andrade, Dalton Francisco, Villar, Betzabeth Slater, Piccinelli, Raffaela, González-Gross, Marcela, Gottrand, Fréderic, Androutsos, Odysseas, Kersting, Mathilde, Michels, Nathalie, Huybrechts, Inge, Widhalm, Kurt, Molnár, Dénes, Marcos, Ascensión, Castillo-Garzón, Manuel J, Moreno, Luis A, HELENA Study Group, on behalf of the, De Bourdeaudhuij, Ilse, De Henauw, Stefaan, De Vriendt, Tineke, Maes, Lea, Matthys, Christophe, Vereecken, Carine, De Maeyer, Mieke, Ottevaere, Charlene, Santos, T. S. S., Julian C., De Andrade D. F., Villar B. S., Piccinelli R., Gonzalez-Gross M., Gottrand F., Androutsos O., Kersting M., Michels N., Huybrechts I., Widhalm K., Molnar D., Marcos A., Castillo-Garzon M. J., Moreno L. A., Scalfi, L., Vitaglione, P., Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), and European Commission

Subjects
0301 basic medicine, Male, Health Knowledge, Attitudes, Practice, Psychometrics, MULTICENTER, Social Sciences, Medicine (miscellaneous), Scales, CHILDREN, Food group, chemistry.chemical_compound, 0302 clinical medicine, DESIGN, Item response theory, Medicine and Health Sciences, Medicine, 030212 general & internal medicine, Child, Nutrition and Dietetics, food and beverages, Europe, Knowledge, CUTOFF, Female, Psychometric, Research Paper, NUTRIENT INTAKE, Adolescent, QUESTIONNAIRE, Nutritional Status, DIETÉTICA, GUIDE, Cobalamin, 03 medical and health sciences, FOOD, Environmental health, Humans, Vitamin B12, Nutrition, 030109 nutrition & dietetics, business.industry, Public Health, Environmental and Occupational Health, Construct validity, HEALTHY LIFE-STYLE, Ascorbic acid, Diet, Cross-Sectional Studies, Nutrition Assessment, chemistry, Blood chemistry, business
Abstract

The HELENA Study Group., [Objective]: To analyse the Nutritional Knowledge Test (NKT) using Item Response Theory (ITR) analysis and to assess the construct validity of the Nutritional Knowledge Scale (NKTS) and its associations with adolescent food group consumption and nutritional biomarkers. [Design]: Cross-sectional study. [Setting]: Multicentre investigation conducted in ten European cities. [Participants]: Adolescents aged 12·5-17·5 years (n 3215) who completed over 75 % of the NKT. [Results]: Factor analysis indicated that the NKT can be analysed with a one-dimensional model. Eleven out of twenty-three items from the NKT presented adequate parameters and were selected to be included in the NKTS. Nutrition knowledge was positively associated with consumption of fruits, cereals, dairy products, pulses, meat and eggs, and fish, as well as with blood concentrations of vitamin C, β-carotene, n-3 fatty acids, holo-transcobalamin, cobalamin and folate; nutrition knowledge was negatively associated with intake of olives and avocado, alcohol and savoury snacks. [Conclusions]: The NKTS assessed nutritional knowledge adequately and it is proposed as a new tool to investigate this subject in future studies., The HELENA study took place with the financial support of the European Community Sixth RTD Framework Programme (contract FOOD-CT-2005-007034). The present study was supported by a grant from Exterior Sandwich Doctorate Program for the Coordination of Improvement of Higher Level Personnel (CAPES, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) (grant number 88881.132853/2016-01).

Published
2018

386. Correlates of ideal cardiovascular health in European adolescents: The HELENA study

Author

P. Henriksson, H. Henriksson, I. Labayen, I. Huybrechts, L. Gracia-Marco, F.B. Ortega, V. España-Romero, Y. Manios, M. González-Gross, A. Marcos, L.A. Moreno, Á. Gutiérrez, J.R. Ruiz, F. Gottrand, S. De Henauw, C. Gilbert, A. Kafatos, C. Libersa, J. Sánchez, M. Kersting, M. Sjöstrom, D. Molnár, J. Dallongeville, G. Hall, L. Maes, L. Scalfi, P. Meléndez, J. Fleta, J.A. Casajús, G. Rodríguez, C. Tomás, M.I. Mesana, G. Vicente-Rodríguez, A. Villarroya, C.M. Gil, I. Ara, J. Revenga, C. Lachen, J.F. Alvira, G. Bueno, A. Lázaro, O. Bueno, J.F. León, J.Ma Garagorri, M. Bueno, J.P. Rey López, I. Iglesia, P. Velasco, S. Bel, J. Wärnberg, E. Nova, S. Gómez-Martinez, L.E. Díaz, J. Romeo, A. Veses, M.A. Puertollano, B. Zapatera, T. Pozo, L. Beghin, C. Iliescu, J. Von Berlepsch, W. Sichert-Hellert, E. Koeppen, D. Molnar, E. Erhardt, K. Csernus, K. Török, S. Bokor, null Angster, E. Nagy, O. Kovács, J. Repásy, C. Codrington, M. Plada, A. Papadaki, K. Sarri, A. Viskadourou, C. Hatzis, M. Kiriakakis, G. Tsibinos, C. Vardavas, M. Sbokos, E. Protoyeraki, M. Fasoulaki, P. Stehle, K. Pietrzik, C. Breidenassel, A. Spinneker, J. Al-Tahan, M. Segoviano, A. Berchtold, C. Bierschbach, E. Blatzheim, A. Schuch, P. Pickert, M.J. Castillo, E.G. Artero, D. Jiménez-Pavón, P. Chillón, D. Arcella, E. Azzini, E. Barrison, N. Bevilacqua, P. Buonocore, G. Catasta, L. Censi, D. Ciarapica, P. D'Acapito, M. Ferrari, M. Galfo, C. Le Donne, C. Leclercq, G. Maiani, B. Mauro, L. Mistura, A. Pasquali, R. Piccinelli, A. Polito, R. Spada, S. Sette, M. Zaccaria, P. Vitaglione, C. Montagnese, I. De Bourdeaudhuij, T. De Vriendt, C. Matthys, C. Vereecken, M. de Maeyer, C. Ottevaere, K. Widhalm, K. Phillipp, S. Dietrich, B. Kubelka, M. Boriss-Riedl, E. Grammatikaki, Z. Bouloubasi, T.L. Cook, S. Eleutheriou, O. Consta, G. Moschonis, I. Katsaroli, G. Kraniou, S. Papoutsou, D. Keke, I. Petraki, E. Bellou, S. Tanagra, K. Kallianoti, D. Argyropoulou, K. Kondaki, S. Tsikrika, C. Karaiskos, A. Meirhaeghe, P. Bergman, M. Hagströmer, L. Hallström, M. Hallberg, E. Poortvliet, N. Rizzo, L. Beckman, A.H. Wennlöf, E. Patterson, L. Kwak, L. Cernerud, P. Tillgren, S. Sörensen, J. Sánchez-Molero, E. Picó, M. Navarro, B. Viadel, J.E. Carreres, G. Merino, R. Sanjuán, M. Lorente, M.J. Sánchez, S. Castelló, S. Thomas, E. Allchurch, P. Burguess, A. Astrom, A. Sverkén, A. Broberg, A. Masson, C. Lehoux, P. Brabant, P. Pate, L. Fontaine, A. Sebok, T. Kuti, A. Hegyi, C. Maldonado, A. Llorente, E. García, H. von Fircks, M.L. Hallberg, M. Messerer, M. Larsson, H. Fredriksson, V. Adamsson, I. Börjesson, L. Fernández, L. Smillie, J. Wills, J. Valtueña, U. Albers, R. Pedrero, A. Meléndez, P.J. Benito, J. Calderón, J.J. Gómez Lorente, D. Cañada, A. Urzanqui, J. Carlos Ortiz, F. Fuentes, R. María Torres, P. Navarro, European Commission, Ministerio de Ciencia e Innovación (España), Ministerio de Sanidad (España), Universidad de Granada, Swedish Society of Medicine, Henriksson, P., Henriksson, H., Labayen, I., Huybrechts, I., Gracia-Marco, L., Ortega, F. B., España-Romero, V., Manios, Y., González-Gross, M., Marcos, A., Moreno, L. A., Gutiérrez, Ã ., Ruiz, J. R., Gottrand, F., De Henauw, S., Gilbert, C., Kafatos, A., Libersa, C., Sánchez, J., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Mesana, M. I., Vicente-Rodríguez, G., Villarroya, A., Gil, C. M., Ara, I., Revenga, J., Lachen, C., Alvira, J. F., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. M., Bueno, M., Rey López, J. P., Iglesia, I., Velasco, P., Bel, S., Wärnberg, J., Nova, E., Gómez-Martinez, S., Díaz, L. E., Romeo, J., Veses, A., Puertollano, M. A., Zapatera, B., Pozo, T., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Null, Nagy, E., Kovács, O., Repásy, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M. J., Artero, E. G., Jiménez-Pavón, D., Chillón, P., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Widhalm, K., Phillipp, K., Dietrich, S., Kubelka, B., Boriss-Riedl, M., Grammatikaki, E., Bouloubasi, Z., Cook, T. L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Kondaki, K., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Bergman, P., Hagströmer, M., Hallström, L., Hallberg, M., Poortvliet, E., Rizzo, N., Beckman, L., Wennlöf, A. H., Patterson, E., Kwak, L., Cernerud, L., Tillgren, P., Sörensen, S., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J. E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M. J., Castelló, S., Thomas, S., Allchurch, E., Burguess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M. L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Valtueña, J., Albers, U., Pedrero, R., Meléndez, A., Benito, P. J., Calderón, J., Gómez Lorente, J. J., Cañada, D., Urzanqui, A., Carlos Ortiz, J., Fuentes, F., María Torres, R., and Navarro, P.

Subjects
Blood Glucose, Male, Health Knowledge, Attitudes, Practice, Adolescent, Epidemiology, Health Status, Endocrinology, Diabetes and Metabolism, Health Behavior, Ideal Body Weight, Medicine (miscellaneous), Blood Pressure, Health Promotion, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Nutrition and Dietetic, Health Status Indicators, Humans, Socioeconomic statu, Healthy Lifestyle, 030212 general & internal medicine, Exercise, Public health, Nutrition and Dietetics, Prevention, Smoking, Age Factors, Protective Factors, Cardiovascular health, Europe, Primary Prevention, Cholesterol, Cross-Sectional Studies, Adolescent Behavior, Cardiovascular Diseases, Television, Female, Risk factor, Diet, Healthy, Cardiology and Cardiovascular Medicine, Biomarkers
Abstract

On behalf of the HELENA Study Group., [Background and aims]: The ideal cardiovascular health (iCVH) construct consists of 4 health behaviors (smoking status, body mass index, physical activity and diet) and 3 health factors (total cholesterol, blood pressure and fasting glucose). A greater number of iCVH components in adolescence are related to better cardiovascular health, but little is known about the correlates of iCVH in adolescents. Thus, the aim of the study was to examine correlates of iCVH in European adolescents., [Methods and results]: The study comprised 637 European adolescents with complete iCVH data. Participants were part of the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional, multicenter study conducted in 9 different European countries. Correlates investigated were sex and age, family affluence scale, maternal education, geographic location, sleep time, television viewing, duration of pregnancy, birth weight and breastfeeding. Younger adolescents, those whose mothers had medium/high education or those who watched television less than 2 h per day had a greater number of iCVH components compared to those who were older, had a mother with low education or watched television 2 h or more daily (P ≤ 0.01)., [Conclusion]: Since in our study older adolescents had worse iCVH than younger adolescents, early promotion of cardiovascular health may be important. Future studies may also investigate the usefulness of limiting television viewing to promote iCVH. Finally, since adolescents of mothers with low education had poorer iCVH, it may be of special interest to tailor public health promotion to adolescents from families with low socioeconomic status., The HELENA project was supported by the European Community Sixth RTD Framework Programme (contract FOOD-CT-2005-007034). The data for this study was gathered under the aegis of the HELENA project, and further analysis was additionally supported by the Spanish Ministry of Economy and Competitiveness (grants RYC-2010-05957 and RYC-2011-09011), the Spanish Ministry of Health: Maternal, Child Health and Development Network (grant RD16/0022), the Fondo Europeo de Desarrollo Regional (MICINN-FEDER) and by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES). Pontus Henriksson was supported by a grant from Henning and Johan Throne-Holst Foundation. Hanna Henriksson was supported by grants from the Swedish Society of Medicine and the County Council of Östergötland, Sweden. Dr. Gracia-Marco acknowledges “Programa de Captación de Talento - UGR Fellows” as part of “Plan Propio” of the University of Granada (Spain).

Published
2018

388. Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study

Author

E.M. González-Gil, C. Cadenas-Sanchez, J. Santabárbara, G. Bueno-Lozano, I. Iglesia, M. González-Gross, D. Molnar, F. Gottrand, S. De Henauw, A. Kafatos, K. Widhalm, Y. Manios, A. Siani, F. Amaro-Gahete, A.I. Rupérez, D. Cañada, L. Censi, M. Kersting, J. Dallongeville, A. Marcos, F.B. Ortega, L.A. Moreno, C. Gilbert, C. Libersa, S. Castelló, M. Sjöstrom, D. Molnár, G. Hall, L. Maes, L. Scalfi, P. Meléndez, J. Fleta, J.A. Casajús, G. Rodríguez, C. Tomás, M.I. Mesana, G. Vicente-Rodríguez, A. Villarroya, C.M. Gil, I. Ara, J.F. Alvira, G. Bueno, A. Lázaro, O. Bueno, J.F. León, J.Ma Garagorri, M. Bueno, I. Labayen, S. Bel Serrat, L.A. Gracia Marco, T. Mouratidou, A. Santaliestra-Pasías, P. De Miguel-Etayo, C. Julián Almárcegui, M. Miguel-Berges, I. Iguacel, J. Wärnberg, E. Nova, S. Gómez, L.E. Díaz, J. Romeo, A. Veses, B. Zapatera, T. Pozo, D. Martínez, L. Beghin, C. Iliescu, J. Von Berlepsch, W. Sichert-Hellert, E. Koeppen, E. Erhardt, K. Csernus, K. Török, S. Bokor, null Angster, E. Nagy, O. Kovács, J. Répasi, C. Codrington, M. Plada, A. Papadaki, K. Sarri, A. Viskadourou, C. Hatzis, M. Kiriakakis, G. Tsibinos, C. Vardavas, M. Sbokos, E. Protoyeraki, M. Fasoulaki, P. Stehle, K. Pietrzik, C. Breidenassel, A. Spinneker, J. Al-Tahan, M. Segoviano, A. Berchtold, C. Bierschbach, E. Blatzheim, A. Schuch, P. Pickert, M.J. Castillo, Á. Gutiérrez, J.R. Ruiz, E.G. Artero, V. España, D. Jiménez-Pavón, P. Chillón, C. Sánchez-Muñoz, M. Cuenca, D. Arcella, E. Azzini, E. Barrison, N. Bevilacqua, P. Buonocore, G. Catasta, D. Ciarapica, P. D'Acapito, M. Ferrari, M. Galfo, C. Le Donne, C. Leclercq, G. Maiani, B. Mauro, L. Mistura, A. Pasquali, R. Piccinelli, A. Polito, R. Roccaldo, R. Spada, S. Sette, M. Zaccaria, P. Vitaglione, C. Montagnese, I. De Bourdeaudhuij, T. De Vriendt, C. Matthys, C. Vereecken, M. de Maeyer, C. Ottevaere, I. Huybrechts, K. Phillipp, S. Dietrich, E. Grammatikaki, Z. Bouloubasi, T.L. Cook, S. Eleutheriou, O. Consta, G. Moschonis, I. Katsaroli, G. Kraniou, S. Papoutsou, D. Keke, I. Petraki, E. Bellou, S. Tanagra, K. Kallianoti, D. Argyropoulou, S. Tsikrika, C. Karaiskos, A. Meirhaeghe, M. Hagströmer, A.H. Wennlöf, L. Hallström, E. Patterson, L. Kwak, N. Rizzo, J. Sánchez-Molero, E. Picó, M. Navarro, B. Viadel, J.E. Carreres, G. Merino, R. Sanjuán, M. Lorente, M.J. Sánchez, S. Thomas, E. Allchurch, P. Burgess, A. Astrom, A. Sverkén, A. Broberg, A. Masson, C. Lehoux, P. Brabant, P. Pate, L. Fontaine, A. Sebok, T. Kuti, A. Hegyi, C. Maldonado, A. Llorente, E. García, H. von Fircks, M.L. Hallberg, M. Messerer, M. Larsson, H. Fredriksson, V. Adamsson, I. Börjesson, L. Fernández, L. Smillie, J. Wills, R. Pedrero-Chamizo, A. Meléndez, J. Valtueña, U. Albers, P.J. Benito, J.J. Gómez Lorente, A. Urzanqui, R.M. Torres, P. Navarro, González-Gil, E. M., Cadenas-Sanchez, C., Santabárbara, J., Bueno-Lozano, G., Iglesia, I., González-Gross, M., Molnar, D., Gottrand, F., De Henauw, S., Kafatos, A., Widhalm, K., Manios, Y., Siani, A., Amaro-Gahete, F., Rupérez, A. I., Cañada, D., Censi, L., Kersting, M., Dallongeville, J., Marcos, A., Ortega, F. B., Moreno, L. A., Gilbert, C., Libersa, C., Castelló, S., Sjöstrom, M., Molnár, D., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Mesana, M. I., Vicente-Rodríguez, G., Villarroya, A., Gil, C. M., Ara, I., Alvira, J. F., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. Ma, Bueno, M., Labayen, I., Bel Serrat, S., Gracia Marco, L. A., Mouratidou, T., Santaliestra-Pasías, A., De Miguel-Etayo, P., Julián Almárcegui, C., Miguel-Berges, M., Iguacel, I., Wärnberg, J., Nova, E., Gómez, S., Díaz, L. E., Romeo, J., Veses, A., Zapatera, B., Pozo, T., Martínez, D., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Null, Nagy, E., Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M. J., Gutiérrez, Ã ., Ruiz, J. R., Artero, E. G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Roccaldo, R., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Phillipp, K., Dietrich, S., Grammatikaki, E., Bouloubasi, Z., Cook, T. L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Hagströmer, M., Wennlöf, A. H., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J. E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M. J., Thomas, S., Allchurch, E., Burgess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M. L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Valtueña, J., Albers, U., Benito, P. J., Gómez Lorente, J. J., Urzanqui, A., Torres, R. M., Navarro, P., Ministerio de Economía y Competitividad (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Stockholm County Council, and Ministerio de Ciencia e Innovación (España)

Subjects
Male, Pediatric Obesity, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Health Status, Physiology, Medicine (miscellaneous), 030204 cardiovascular system & hematology, Body Mass Index, 0302 clinical medicine, Risk Factors, Nutrition and Dietetic, adolescents, Metabolic Syndrome, Nutrition and Dietetics, biology, Age Factors, Interleukin, Complement C4, Inflammatory biomarkers, Complement C3, Prognosis, Europe, C-Reactive Protein, Female, medicine.symptom, Inflammation Mediators, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Adolescent, Metabolic health, 030209 endocrinology & metabolism, Inflammation, 03 medical and health sciences, Sex Factors, Internal medicine, medicine, Humans, business.industry, C-reactive protein, Case-control study, medicine.disease, Endocrinology, Blood pressure, Cross-Sectional Studies, Case-Control Studies, biology.protein, Metabolic syndrome, business, Body mass index, Inflammatory biomarker, Biomarkers
Abstract

On behalf of the HELENA study group., [Background and aims] Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. [Methods and results] A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. [Results] Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. [Conclusions] Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently., The HELENA Study was supported by the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034) and the Stockholm County Council. This analysis was also supported by the Spanish Ministry of Science and Innovation (JCI-2010-07055) and the gs4:European Regional Development Fund (FEDER). CCS is supported by the Spanish Ministry of Economy and Competitiveness (BES-2014-068829). FBO is supported by a grant from the Spanish Ministry of Science and Innovation (RYC-2011-09011). AIR was funded by a Juan de la Cierva-Formación stipend from the Ministry of Economy and Competitiveness of the Spanish Government (FJCI-2014-19795).

Published
2017

389. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants

Author

Zhou, B, Lu, Y, Hajifathalian, K, Bentham, J, Di Cesare, M, Danaei, G, Bixby, H, Cowan, Mj, Ali, Mk, Taddei, C, Wc, Lo, Reis Santos, B, Stevens, Ga, Riley, Lm, Miranda, Jj, Bjerregaard, P, Rivera, Ja, Fouad, Hm, Ma, G, Mbanya, Jc, Mcgarvey, St, Mohan, V, Onat, A, Pilav, A, Ramachandran, A, Romdhane, Hb, Paciorek, Cj, Bennett, Je, Ezzati, M, Abdeen, Za, Abdul Kadir, K, Abu Rmeileh, Nm, Acosta Cazares, B, Adams, R, Aekplakorn, W, Aguilar Salinas, Ca, Agyemang, C, Ahmadvand, A, Al Othman, Ar, Alkerwi, A, Amouyel, P, Amuzu, A, Andersen, Lb, Anderssen, Sa, Anjana, Rm, Aounallah Skhiri, H, Aris, T, Arlappa, N, Arveiler, D, Assah, Fk, Avdicová, M, Azizi, F, Balakrishna, N, Bandosz, P, Barbagallo, Cm, Barceló, A, Batieha, Am, Baur, La, Benet, M, Bernabe Ortiz, A, Bharadwaj, S, Bhargava, Sk, Bi, Y, Bjertness, E, Bjertness, Mb, Björkelund, C, Blokstra, A, Bo, S, Boehm, Bo, Boissonnet, Cp, Bovet, P, Brajkovich, I, Breckenkamp, J, Brenner, H, Brewster, Lm, Brian, Gr, Bruno, G, Bugge, A, Cabrera de León, A, Can, G, Cândido, Ap, Capuano, V, Carlsson, Ac, Carvalho, Mj, Casanueva, Ff, Casas, Jp, Caserta, Ca, Castetbon, K, Chamukuttan, S, Chaturvedi, N, Chen, Cj, Chen, F, Chen, S, Cheng, Cy, Chetrit, A, Chiou, St, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Concin, H, Cooper, C, Cooper, R, Costanzo, S, Cottel, D, Cowell, C, Crujeiras, Ab, D'Arrigo, G, Dallongeville, J, Dankner, R, Dauchet, L, de Gaetano, G, De Henauw, S, Deepa, M, Dehghan, A, Deschamps, V, Dhana, K, Di Castelnuovo, Af, Djalalinia, S, Doua, K, Drygas, W, Du, Y, Dzerve, V, Egbagbe, Ee, Eggertsen, R, El Ati, J, Elosua, R, Erasmus, Rt, Erem, C, Ergor, G, Eriksen, L, Escobedo de la Peña, J, Fall, Ch, Farzadfar, F, Felix Redondo, Fj, Ferguson, Ts, Fernández Bergés, D, Ferrari, M, Ferreccio, C, Feskens, Ej, Finn, Jd, Föger, B, Foo, Lh, Forslund, As, Francis, Dk, Franco Mdo, C, Franco, Oh, Frontera, G, Furusawa, T, Gaciong, Z, Garnett, Sp, Gaspoz, Jm, Gasull, M, Gates, L, Geleijnse, Jm, Ghasemian, A, Ghimire, A, Giampaoli, S, Gianfagna, Francesco, Giovannelli, J, Giwercman, A, Gross, Mg, González Rivas, Jp, Gorbea, Mb, Gottrand, F, Grafnetter, D, Grodzicki, T, Grøntved, A, Gruden, G, Gu, D, Guan, Op, Guerrero, R, Guessous, I, Guimaraes, Al, Gutierrez, L, Hambleton, Ir, Hardy, R, Hari Kumar, R, Hata, J, He, J, Heidemann, C, Herrala, S, Hihtaniemi, It, Sy, Ho, Sc, Ho, Hofman, A, Hormiga, Cm, Horta, Bl, Houti, L, Howitt, C, Htay, Tt, Htet, As, Htike, Mm, Hu, Y, Hussieni, As, Huybrechts, I, Hwalla, N, Iacoviello, Licia, Iannone, Ag, Ibrahim, Mm, Ikeda, N, Ikram, Ma, Irazola, Ve, Islam, M, Iwasaki, M, Jacobs, Jm, Jafar, T, Jamil, Km, Jasienska, G, Jiang, Cq, Jonas, Jb, Joshi, P, Kafatos, A, Kalter Leibovici, O, Kasaeian, A, Katz, J, Kaur, P, Kavousi, M, Keinänen Kiukaanniemi, S, Kelishadi, R, Kengne, Ap, Kersting, M, Khader, Ys, Khalili, D, Khang, Yh, Kiechl, S, Kim, J, Kolsteren, P, Korrovits, P, Kratzer, W, Kromhout, D, Kujala, Um, Kula, K, Kyobutungi, C, Laatikainen, T, Lachat, C, Laid, Y, Lam, Th, Landrove, O, Lanska, V, Lappas, G, Laxmaiah, A, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León Muñoz, Lm, Li, Y, Lim, Wy, Lima Costa, Mf, Lin, Hh, Lin, X, Lissner, L, Lorbeer, R, Lozano, Je, Luksiene, D, Lundqvist, A, Lytsy, P, Machado Coelho, Gl, Machi, S, Maggi, S, Magliano, Dj, Makdisse, M, Mallikharjuna Rao, K, Manios, Y, Manzato, E, Margozzini, P, Marques Vidal, P, Martorell, R, Masoodi, Sr, Mathiesen, Eb, Matsha, Te, Mcfarlane, Sr, Mclachlan, S, Mcnulty, Ba, Mediene Benchekor, S, Meirhaeghe, A, Menezes, Am, Merat, S, Meshram, Ii, Mi, J, Miquel, Jf, Mohamed, Mk, Mohammad, K, Mohammadifard, N, Mohd Yusoff, Mf, Møller, Nc, Molnár, D, Mondo, Ck, Morejon, A, Moreno, La, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Motta, J, Tt, Mu, Muiesan, Ml, Müller Nurasyid, M, Mursu, J, Nagel, G, Námešná, J, Nang, Ee, Nangthetia, Vb, Navarrete Muñoz, Em, Ndiaye, Nc, Nenko, I, Nervi, F, Nguyen, Nd, Nguyen, Qn, Nieto Martínez, Re, Ning, G, Ninomiya, T, Noale, M, Noto, D, Nsour, Ma, Ochoa Avilés, Am, Oh, K, Ordunez, P, Osmond, C, Otero, Ja, Owusu Dabo, E, Pahomova, E, Palmieri, L, Panda Jonas, S, Panza, F, Parsaeian, M, Peixoto, Sv, Peltonen, M, Peters, A, Peykari, N, Pham, St, Pitakaka, F, Piwonska, A, Piwonski, J, Plans Rubió, P, Porta, M, Portegies, Ml, Poustchi, H, Pradeepa, R, Price, Jf, Punab, M, Qasrawi, Rf, Qorbani, M, Radisauskas, R, Rahman, M, Raitakari, O, Rao, Sr, Ramke, J, Ramos, R, Rampal, S, Rathmann, W, Redon, J, Reganit, Pf, Rigo, F, Robinson, Sm, Robitaille, C, Rodríguez Artalejo, F, Rodriguez Perez Mdel, C, Rodríguez Villamizar, La, Rojas Martinez, R, Ronkainen, K, Rosengren, A, Rubinstein, A, Rui, O, Ruiz Betancourt, Bs, Russo Horimoto, Rv, Rutkowski, M, Sabanayagam, C, Sachdev, Hs, Saidi, O, Sakarya, S, Salanave, B, Salonen, Jt, Salvetti, M, Sánchez Abanto, J, Santos, D, dos Santos, Rn, Santos, R, Saramies, Jl, Sardinha, Lb, Sarrafzadegan, N, Saum, Ku, Scazufca, M, Schargrodsky, H, Scheidt Nave, C, Sein, Aa, Sharma, Sk, Shaw, Je, Shibuya, K, Shin, Y, Shiri, R, Siantar, R, Sibai, Am, Simon, M, Simons, J, Simons, La, Sjostrom, M, Slowikowska Hilczer, J, Slusarczyk, P, Smeeth, L, Snijder, Mb, Hk, So, Sobngwi, E, Söderberg, S, Solfrizzi, V, Sonestedt, E, Soumare, A, Staessen, Ja, Stathopoulou, Mg, Steene Johannessen, J, Stehle, P, Stein, Ad, Stessman, J, Stöckl, D, Stokwiszewski, J, Stronks, K, Strufaldi, Mw, Sun, Ca, Sundström, J, Sung, Yt, Suriyawongpaisal, P, Rg, Sy, Tai, Es, Tamosiunas, A, Tang, L, Tarawneh, M, Tarqui Mamani, Cb, Taylor, A, Theobald, H, Thijs, L, Thuesen, Bh, Tolonen, Hk, Tolstrup, Js, Topbas, M, Torrent, M, Traissac, P, Trinh, Ot, Tulloch Reid, Mk, Tuomainen, Tp, Turley, Ml, Tzourio, C, Ueda, P, Ukoli, Fa, Ulmer, H, Uusitalo, Hm, Valdivia, G, Valvi, D, van Rossem, L, van Valkengoed, Ig, Vanderschueren, D, Vanuzzo, D, Vega, T, Velasquez Melendez, G, Veronesi, Giovanni, Verschuren, Wm, Verstraeten, R, Viet, L, Vioque, J, Virtanen, Jk, Visvikis Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Vrijheid, M, Wade, An, Wagner, A, Walton, J, Wan Mohamud, Wn, Wang, F, Wang, Md, Wang, Q, Wang, Yx, Wannamethee, Sg, Weerasekera, D, Whincup, Ph, Widhalm, K, Wiecek, A, Wijga, Ah, Wilks, Rj, Willeit, J, Wilsgaard, T, Wojtyniak, B, Wong, Ty, Woo, J, Woodward, M, Fc, Wu, Sl, Wu, Xu, H, Yan, W, Yang, X, Ye, X, Yoshihara, A, Younger Coleman, No, Zambon, S, Zargar, Ah, Zdrojewski, T, Zhao, W, Zheng, Y, Zuñiga Cisneros, J., Zhou B., Lu Y., Hajifathalian K., Bentham J., Di Cesare M., Danaei G., Bixby H., Cowan M.J., Ali M.K., Taddei C., Lo W.-C., Reis-Santos B., Stevens G.A., Riley L.M., Miranda J.J., Bjerregaard P., Rivera J.A., Fouad H.M., Ma G., Mbanya J.C.N., McGarvey S.T., Mohan V., Onat A., Pilav A., Ramachandran A., Ben Romdhane H., Paciorek C.J., Bennett J.E., Ezzati M., Abdeen Z.A., Kadir K.A., Abu-Rmeileh N.M., Acosta-Cazares B., Adams R., Aekplakorn W., Aguilar-Salinas C.A., Agyemang C., Ahmadvand A., Al-Othman A.R., Alkerwi A., Amouyel P., Amuzu A., Bo Andersen L., Anderssen S.A., Anjana R.M., Aounallah-Skhiri H., Aris T., Arlappa N., Arveiler D., Assah F.K., Avdicova M., Azizi F., Balakrishna N., Bandosz P., Barbagallo C.M., Barcelo A., Batieha A.M., Baur L.A., Benet M., Bernabe-Ortiz A., Bharadwaj S., Bhargava S.K., Bi Y., Bjertness E., Bjertness M.B., Bjorkelund C., Blokstra A., Bo S., Boehm B.O., Boissonnet C.P., Bovet P., Brajkovich I., Breckenkamp J., Brenner H., Brewster L.M., Brian G.R., Bruno G., Bugge A., De Leon A.C., Can G., Candido A.P.C., Capuano V., Carlsson A.C., Carvalho M.J., Casanueva F.F., Casas J.-P., Caserta C.A., Castetbon K., Chamukuttan S., Chaturvedi N., Chen C.-J., Chen F., Chen S., Cheng C.-Y., Chetrit A., Chiou S.-T., Cho Y., Chudek J., Cifkova R., Claessens F., Concin H., Cooper C., Cooper R., Costanzo S., Cottel D., Cowell C., Crujeiras A.B., D'Arrigo G., Dallongeville J., Dankner R., Dauchet L., De Gaetano G., De Henauw S., Deepa M., Dehghan A., Deschamps V., Dhana K., Di Castelnuovo A.F., Djalalinia S., Doua K., Drygas W., Du Y., Dzerve V., Egbagbe E.E., Eggertsen R., El Ati J., Elosua R., Erasmus R.T., Erem C., Ergor G., Eriksen L., Escobedo-De La Pena J., Fall C.H., Farzadfar F., Felix-Redondo F.J., Ferguson T.S., Fernandez-Berges D., Ferrari M., Ferreccio C., Feskens E.J.M., Finn J.D., Foger B., Foo L.H., Forslund A.-S., Francis D.K., Do Carmo Franco M., Franco O.H., Frontera G., Furusawa T., Gaciong Z., Garnett S.P., Gaspoz J.-M., Gasull M., Gates L., Geleijnse J.M., Ghasemian A., Ghimire A., Giampaoli S., Gianfagna F., Giovannelli J., Giwercman A., Gross M.G., Rivas J.P.G., Gorbea M.B., Gottrand F., Grafnetter D., Grodzicki T., Grontved A., Gruden G., Gu D., Guan O.P., Guerrero R., Guessous I., Guimaraes A.L., Gutierrez L., Hambleton I.R., Hardy R., Kumar R.H., Hata J., He J., Heidemann C., Herrala S., Hihtaniemi I.T., Ho S.Y., Ho S.C., Hofman A., Hormiga C.M., Horta B.L., Houti L., Howitt C., Htay T.T., Htet A.S., Htike M.M.T., Hu Y., Hussieni A.S., Huybrechts I., Hwalla N., Iacoviello L., Iannone A.G., Ibrahim M.M., Ikeda N., Ikram M.A., Irazola V.E., Islam M., Iwasaki M., Jacobs J.M., Jafar T., Jamil K.M., Jasienska G., Jiang C.Q., Jonas J.B., Joshi P., Kafatos A., Kalter-Leibovici O., Kasaeian A., Katz J., Kaur P., Kavousi M., Keinanen-Kiukaanniemi S., Kelishadi R., Kengne A.P., Kersting M., Khader Y.S., Khalili D., Khang Y.-H., Kiechl S., Kim J., Kolsteren P., Korrovits P., Kratzer W., Kromhout D., Kujala U.M., Kula K., Kyobutungi C., Laatikainen T., Lachat C., Laid Y., Lam T.H., Landrove O., Lanska V., Lappas G., Laxmaiah A., Leclercq C., Lee J., Lehtimaki T., Lekhraj R., Leon-Munoz L.M., Li Y., Lim W.-Y., Lima-Costa M.F., Lin H.-H., Lin X., Lissner L., Lorbeer R., Lozano J.E., Luksiene D., Lundqvist A., Lytsy P., Machado-Coelho G.L.L., Machi S., Maggi S., Magliano D.J., Makdisse M., Rao K.M., Manios Y., Manzato E., Margozzini P., Marques-Vidal P., Martorell R., Masoodi S.R., Mathiesen E.B., Matsha T.E., McFarlane S.R., McLachlan S., McNulty B.A., Mediene-Benchekor S., Meirhaeghe A., Menezes A.M.B., Merat S., Meshram I.I., Mi J., Miquel J.F., Mohamed M.K., Mohammad K., Mohammadifard N., Mohd Yusoff M.F., Moller N.C., Molnar D., Mondo C.K., Morejon A., Moreno L.A., Morgan K., Moschonis G., Mossakowska M., Mostafa A., Mota J., Motta J., Mu T.T., Muiesan M.L., Muller-Nurasyid M., Mursu J., Nagel G., Namesna J., Nang E.E.K., Nangia V.B., Navarrete-Munoz E.M., Ndiaye N.C., Nenko I., Nervi F., Nguyen N.D., Nguyen Q.N., Nieto-Martinez R.E., Ning G., Ninomiya T., Noale M., Noto D., Al Nsour M., Ochoa-Aviles A.M., Oh K., Ordunez P., Osmond C., Otero J.A., Owusu-Dabo E., Pahomova E., Palmieri L., Panda-Jonas S., Panza F., Parsaeian M., Peixoto S.V., Peltonen M., Peters A., Peykari N., Pham S.T., Pitakaka F., Piwonska A., Piwonski J., Plans-Rubio P., Porta M., Portegies M.L.P., Poustchi H., Pradeepa R., Price J.F., Punab M., Qasrawi R.F., Qorbani M., Radisauskas R., Rahman M., Raitakari O., Rao S.R., Ramke J., Ramos R., Rampal S., Rathmann W., Redon J., Reganit P.F.M., Rigo F., Robinson S.M., Robitaille C., Rodriguez-Artalejo F., Del CristoRodriguez-Perez M., Rodriguez-Villamizar L.A., Rojas-Martinez R., Ronkainen K., Rosengren A., Rubinstein A., Rui O., Ruiz-Betancourt B.S., Horimoto A.R.V.R., Rutkowski M., Sabanayagam C., Sachdev H.S., Saidi O., Sakarya S., Salanave B., Salonen J.T., Salvetti M., Sanchez-Abanto J., Santos D., Dos Santos R.N., Santos R., Saramies J.L., Sardinha L.B., Sarrafzadegan N., Saum K.-U., Scazufca M., Schargrodsky H., Scheidt-Nave C., Sein A.A., Sharma S.K., Shaw J.E., Shibuya K., Shin Y., Shiri R., Siantar R., Sibai A.M., Simon M., Simons J., Simons L.A., Sjostrom M., Slowikowska-Hilczer J., Slusarczyk P., Smeeth L., Snijder M.B., So H.-K., Sobngwi E., Soderberg S., Solfrizzi V., Sonestedt E., Soumare A., Staessen J.A., Stathopoulou M.G., Steene-Johannessen J., Stehle P., Stein A.D., Stessman J., Stockl D., Stokwiszewski J., Stronks K., Strufaldi M.W., Sun C.-A., Sundstrom J., Sung Y.-T., Suriyawongpaisal P., Sy R.G., Tai E.S., Tamosiunas A., Tang L., Tarawneh M., Tarqui-Mamani C.B., Taylor A., Theobald H., Thijs L., Thuesen B.H., Tolonen H.K., Tolstrup J.S., Topbas M., Torrent M., Traissac P., Trinh O.T.H., Tulloch-Reid M.K., Tuomainen T.-P., Turley M.L., Tzourio C., Ueda P., Ukoli F.A.M., Ulmer H., Uusitalo H.M.T., Valdivia G., Valvi D., Van Rossem L., Van Valkengoed I.G.M., Vanderschueren D., Vanuzzo D., Vega T., Velasquez-Melendez G., Veronesi G., Verschuren W.M.M., Verstraeten R., Viet L., Vioque J., Virtanen J.K., Visvikis-Siest S., Viswanathan B., Vollenweider P., Voutilainen S., Vrijheid M., Wade A.N., Wagner A., Walton J., Wan Mohamud W.N., Wang F., Wang M.-D., Wang Q., Wang Y.X., Wannamethee S.G., Weerasekera D., Whincup P.H., Widhalm K., Wiecek A., Wijga A.H., Wilks R.J., Willeit J., Wilsgaard T., Wojtyniak B., Wong T.Y., Woo J., Woodward M., Wu F.C., Wu S.L., Xu H., Yan W., Yang X., Ye X., Yoshihara A., Younger-Coleman N.O., Zambon S., Zargar A.H., Zdrojewski T., Zhao W., Zheng Y., Cisneros J.Z., Erasmus MC other, Epidemiology, Public Health, Clinical Genetics, Staessen, Jan A, Vanderschueren, Dirk, Claessens, Frank, and Thijs, Lutgarde

Subjects
Male, Blood Glucose, Adult, Research Report, Settore MED/09 - Medicina Interna, glucosa sanguínea, Epidemiology, humanos, prevention, public health, diabetes, coste de las enfermedades, Diabetes, epidemiology, Global Health, incidencia, Worldwide trends, distribución por sexos, Age Distribution, SDG 3 - Good Health and Well-being, Cost of Illness, distribución por edades, países en desarrollo, Diabetes Mellitus, Prevalence, Insulin, Humans, Hypoglycemic Agents, insulina, Age of Onset, Sex Distribution, Developing Countries, VDP::Medical disciplines: 700::Clinical medical disciplines: 750, Incidence, prevalencia, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750, Bayes Theorem, adulto, Health Surveys, informe de investigación, purl.org/pe-repo/ocde/ford#3.02.00 [https], hipoglicemiantes, encuestas de salud, Female, pooled analysis, teorema de Bayes
Abstract

Background One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. Methods We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. Findings We used data from 751 studies including 4 372 000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-7.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target. Interpretation Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults affected, has increased faster in low-income and middle-income countries than in high-income countries. Funding Wellcome Trust., Wellcome Trust.

Published
2016

390. Physical Activity Is Associated with Attention Capacity in Adolescents

Author

Jérémy Vanhelst, Laurent Béghin, Alain Duhamel, Yannis Manios, Denes Molnar, Sefaan De Henauw, Luis A. Moreno, Francisco B. Ortega, Michael Sjöström, Kurt Widhalm, Frédéric Gottrand, Fréderic Gottrand, Stefaan De Henauw, Marcela González-Gross, Chantal Gilbert, Anthony Kafatos, Christian Libersa, Jackie Sánchez, Mathilde Kersting, Michael Sjöstrom, Dénes Molnár, Jean Dallongeville, Gunnar Hall, Lea Maes, Luca Scalfi, Pilar Meléndez, Jesús Fleta, José A. Casajús, Gerardo Rodríguez, Concepción Tomás, María I. Mesana, Germán Vicente-Rodríguez, Adoración Villarroya, Carlos M. Gil, Ignacio Ara, Juan Revenga, Carmen Lachen, Juan Fernández Alvira, Gloria Bueno, Aurora Lázaro, Olga Bueno, Juan F. León, Jesús Mª Garagorri, Manuel Bueno, Juan Pablo Rey López, Iris Iglesia, Paula Velasco, Silvia Bel, Ascensión Marcos, Julia Wärnberg, Esther Nova, Sonia Gómez, Esperanza Ligia Díaz, Javier Romeo, Ana Veses, Mari Angeles Puertollano, Belén Zapatera, Tamara Pozo, David Martínez, Laurent Beghin, Catalina Iliescu, Juliana Von Berlepsch, Wolfgang Sichert-Hellert, Ellen Koeppen, Dénes Molnar, Eva Erhardt, Katalin Csernus, Katalin Török, Szilvia Bokor, Miklós Angster, Enikö Nagy, Orsolya Kovács, Judit Repásy, Caroline Codrington, María Plada, Angeliki Papadaki, Katerina Sarri, Anna Viskadourou, Christos Hatzis, Michael Kiriakakis, George Tsibinos, Constantine Vardavas, Manolis Sbokos, Eva Protoyeraki, Maria Fasoulaki, Peter Stehle, Klaus Pietrzik, Christina Breidenassel, Andre Spinneker, Jasmin Al-Tahan, Miriam Segoviano, Anke Berchtold, Christine Bierschbach, Erika Blatzheim, Adelheid Schuch, Petra Pickert, Manuel J. Castillo, Ángel Gutiérrez, Jonatan R. Ruiz, Enrique G. Artero, Vanesa España-Romero, David Jiménez-Pavón, Palma Chillón, Magdalena Cuenca-García, Davide Arcella, Elena Azzini, Emma Barrison, Noemi Bevilacqua, Pasquale Buonocore, Giovina Catasta, Laura Censi, Donatella Ciarapica, Paola D'Acapito, Marika Ferrari, Myriam Galfo, Cinzia Le Donne, Catherine Leclercq, Giuseppe Maiani, Beatrice Mauro, Lorenza Mistura, Antonella Pasquali, Raffaela Piccinelli, Angela Polito, Raffaella Spada, Stefania Sette, Maria Zaccaria, Paola Vitaglione, Concetta Montagnese, Ilse De Bourdeaudhuij, Tineke De Vriendt, Christophe Matthys, Carine Vereecken, Mieke de Maeyer, Charlene Ottevaere, Inge Huybrechts, Katharina Phillipp, Sabine Dietrich, Birgit Kubelka, Marion Boriss-Riedl, Eva Grammatikaki, Zoi Bouloubasi, Tina Louisa Cook, Sofia Eleutheriou, Orsalia Consta, George Moschonis, Ioanna Katsaroli, George Kraniou, Stalo Papoutsou, Despoina Keke, Ioanna Petraki, Elena Bellou, Sofia Tanagra, Kostalenia Kallianoti, Dionysia Argyropoulou, Katerina Kondaki, Stamatoula Tsikrika, Christos Karaiskos, Aline Meirhaeghe, Patrick Bergman, María Hagströmer, Lena Hallström, Mårten Hallberg, Eric Poortvliet, Nico Rizzo, Linda Beckman, Anita Hurtig Wennlöf, Emma Patterson, Lydia Kwak, Lars Cernerud, Per Tillgren, Stefaan Sörensen, Jackie Sánchez-Molero, Elena Picó, Maite Navarro, Blanca Viadel, José Enrique Carreres, Gema Merino, Rosa Sanjuán, María Lorente, María José Sánchez, Sara Castelló, Sarah Thomas, Elaine Allchurch, Peter Burguess, Annika Astrom, Anna Sverkén, Agneta Broberg, Annick Masson, Claire Lehoux, Pascal Brabant, Philippe Pate, Laurence Fontaine, Andras Sebok, Tunde Kuti, Adrienn Hegyi, Cristina Maldonado, Ana Llorente, Emilio García, Holger von Fircks, Marianne Lilja Hallberg, Maria Messerer, Mats Larsson, Helena Fredriksson, Viola Adamsson, Ingmar Börjesson, Laura Fernández, Laura Smillie, Josephine Wills, Agustín Meléndez, Pedro J. Benito, Javier Calderón, Jara Valtueña, Paloma Navarro, Alejandro Urzanqui, Ulrike Albers, Raquel Pedrero, Juan José Gómez Lorente, Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Inserm, Université de Lille, CHU Lille, Lille Inflammation Research International Center - U 995 [LIRIC], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], Vanhelst, Jérémy, Béghin, Laurent, Duhamel, Alain, Manios, Yanni, Molnar, Dene, De Henauw, Sefaan, Moreno, Luis A, Ortega, Francisco B, Sjöström, Michael, Widhalm, Kurt, Gottrand, Frédéric, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Martínez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, M, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, Á, Ortega, Fb, Ruiz, Jr, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Cuenca García, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.

Subjects
Male, medicine.medical_specialty, Adolescent, Cross-sectional study, Overweight, Motor Activity, 03 medical and health sciences, 0302 clinical medicine, medicine, D2 Test of Attention, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Aerobic exercise, Humans, Attention, 030212 general & internal medicine, Effects of sleep deprivation on cognitive performance, Child, Exercise, 2. Zero hunger, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, business.industry, International Standard Classification of Education, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Cognition, Mesh:Adolescent, Mesh:Attention, Mesh:Child, Mesh:Cross-Sectional Studies, Mesh:Exercise, Mesh:Female, Mesh:Humans, Mesh:Male, Mesh:Motor Activity, 030229 sport sciences, Cross-Sectional Studies, Pediatrics, Perinatology and Child Health, Physical therapy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, medicine.symptom, business, Body mass index, Clinical psychology
Abstract

International audience; Objective: To assess the relationships among physical activity, measured objectively, and attention capacity in European adolescents.Study design: The study included 273 adolescents, aged 12.5-17.5 years, who participated in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Participants wore a uniaxial accelerometer for 7 days to measure physical activity. The d2 Test of Attention was administered to assess attention capacity. Multivariate analyses were used to study the association of attention capacity with each measure of physical activity. Receiver operating characteristic analysis was performed to determine thresholds that best discriminate between low and good attention capacity.Results: After controlling for potential confounding variables (age, sex, body mass index, parental educational level, fat mass, aerobic fitness, and center), adolescents' attention capacity test performances were significantly and positively associated with longer time spent in moderate or moderate-to-vigorous physical activity (MVPA) in free-living conditions (P < .05). Receiver operating characteristic curve analyses revealed that the physical activity thresholds that best discriminated between low/good attention capacities were ≥41 min·day−1 for moderate, ≥12 min·day−1 for vigorous, and ≥58 min·day−1 for MVPA.Conclusion:These findings suggest that promoting MVPA may be have a beneficial effect on attention capacity, an important component of cognition, in adolescents.

Published
2015

391. Abnormal QRS-T angles in 5796 women and men aged 50-64: an electrocardiographic analysis providing mechanistic insights.

Author

Bergfeldt L, Hellsing R, Molnar D, Taha A, Lundahl G, Gransberg L, and Bergström G

Subjects
Humans, Female, Male, Middle Aged, Sweden, Electrocardiography, Vectorcardiography methods
Abstract

Introduction: Abnormal QRS-T angles are prognostic markers for cardiovascular deaths including sudden cardiac death. They occur in ∼5-6% of population-based cohorts but in ∼20% of patients with diabetes. The mechanistic background, electrical activation and/or recovery disturbances, is not known and the topic of this study., Methods: Applying Frank vectorcardiography (VCG) and simultaneously recorded scalar 12‑lead ECG, electrical activation and recovery of abnormal QRS-T angles were studied in 311 participants (5.4%) from a population-based cohort of 5796 women and men in the main Swedish CArdio-Pulmonary bio-Imaging Study (SCAPIS) in Gothenburg. Cut-off values for the peak and mean QRS-T angles were > 124° and > 119°, based on the >95th percentile among all 1080 participants in the pilot SCAPIS and reference values for normal directions (Q1-Q3) from 319 apparently healthy (30%) of them., Results: Of 311 cases 17% had known cardiac disease. Deviations of QRS and QRSarea-vectors from reference limits (90%) were significantly more common than deviations of T- and Tarea-vectors (65%). Standard ECG signs suggested pathophysiology in 20%; left bundle branch block (LBBB) and voltage criteria for left ventricular hypertrophy being most frequent (9-10%) each. Sub-group analysis of the 30 with LBBB showed very large variability in vector directions., Conclusions: Our observations provide mechanistic insights about abnormal QRS-T angles of potential value for future prognostic and interventional studies. The results also have potential implications for LBB area pacing and the approach to left ventricular hypertrophy., Competing Interests: Declaration of competing interest There are no disclosures to be made for any of the authors in relation to this work., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2024
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392. Burden of respiratory syncytial virus infections in older adults with acute respiratory infection in Japan: An epidemiological study among outpatients.

Author

Ohbayashi H, Sakurai T, Himeji D, Fukushima Y, Takahashi H, Kiyosue A, Sabater Cabrera E, Matsuki T, Molnar D, Preckler Moreno V, Damaso S, Pirçon JY, and Moitinho de Almeida M

Subjects
Humans, Aged, Japan epidemiology, Acute Disease, Middle Aged, Female, Male, Prevalence, Aged, 80 and over, Cost of Illness, Hospitalization statistics & numerical data, Respiratory Syncytial Virus, Human isolation & purification, Respiratory Syncytial Virus Infections epidemiology, Respiratory Tract Infections epidemiology, Respiratory Tract Infections virology, Quality of Life, Outpatients statistics & numerical data
Abstract

Background: Respiratory syncytial virus (RSV) is a leading cause of acute respiratory illness, with severe outcomes in older adults. Information on the prevalence, hospitalization rate, and impact on the health-related quality of life (HRQoL) of RSV in older adults with acute respiratory infections (ARI) in outpatient settings in Japan is limited., Methods: This multi-center epidemiological study included outpatients aged ≥60 years presenting with ARI between August 2021 and February 2023. Nasal and throat swabs were collected and tested by reverse transcription polymerase chain reaction (RT-PCR). The prevalence of RT-PCR-confirmed RSV (cRSV)-ARI, cRSV-lower respiratory tract disease (LRTD), and other respiratory viruses was calculated by season, region, age group, and RSV subtype. HRQoL was assessed via patient-reported outcomes., Results: The study included 923 ARI episodes (cRSV-ARI: N = 24; non-cRSV-ARI: N = 899). In years 1 and 2 (August 2021-July 2022 and August 2022-February 2023), the prevalence of cRSV-ARI was 2.5% and 2.8%, respectively. There was a predominance of RSV-B and RSV-A subtypes in years 1 and 2, respectively. In years 1 and 2 combined, 37.5% of cRSV-ARI cases had lower respiratory tract infection; all cRSV-LRTD cases occurred in those aged 60-74 years. RSV-ARI cases reported throat, chest, and respiratory symptoms, leading to impaired functioning and HRQoL., Conclusions: During the observed study period, RSV was circulating among older adults in Japan. RSV was a leading cause of ARI and LRTD. More data are needed to fully clarify the burden of RSV among older adults in Japan., Competing Interests: Declaration of Competing interest Eliazar Sabater Cabrera has been employed by and has held financial equities in GSK; Daniel Molnar was employed by and held financial equities in GSK during the conduct of the study and preparation of the manuscript; Silvia Damaso has been employed by and has held financial equities in GSK; Jean-Yves Pirçon has been employed by and has held financial equities in GSK; Maria Moitinho de Almeida has been employed by and has held financial equities in GSK; Victor Preckler Moreno was employed by and held financial equities in GSK when the study was conducted; Taizo Matsuki was employed by and held financial equities in GSK when the study was conducted, and is currently employed by MSD; Hiroshi Takahashi received funding from GSK to conduct this study; Daisuke Himeji received funding from GSK to conduct this study. Yasushi Fukushima received funding from GSK to conduct this study. These authors declare no other financial or non-financial relationships and activities. Hiroyuki Ohbayashi declares no financial or non-financial relationships and activities and no conflicts of interest; Takayuki Sakurai declares no financial or non-financial relationships and activities and no conflicts of interest; Arihiro Kiyosue declares no financial or non-financial relationships and activities and no conflicts of interest., (Copyright © 2024 [Author/Employing Institution]. Published by Elsevier B.V. All rights reserved.)

Published
2024
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393. Public Health Impact of the Adjuvanted RSVPreF3 Vaccine for Respiratory Syncytial Virus Prevention Among Older Adults in the United States.

Author

Molnar D, La EM, Verelst F, Poston S, Graham J, Van Bellinghen LA, and Curran D

Abstract

Introduction: Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract disease in older adults, resulting in substantial morbidity and mortality., Methods: This study estimates the public health impact of vaccination with the adjuvanted RSVPreF3 vaccine among adults aged ≥ 60 years in the United States (US). A static, multi-cohort Markov model was used to estimate RSV-related outcomes over a 3-year time horizon for scenarios with and without one-time RSV vaccination. The base-case analysis assumed the same vaccination coverage as for influenza vaccines, with key epidemiology and vaccine inputs obtained from the published literature and phase 3 clinical trial results for the adjuvanted RSVPreF3 vaccine. Model outcomes included the clinical burden of RSV (symptomatic RSV acute respiratory illness [RSV-ARI] cases [classified as upper or lower respiratory tract disease], pneumonia complications, and mortality) and RSV-related healthcare resource use (hospitalizations, emergency department visits, outpatient visits, and antibiotic prescriptions)., Results: In the base-case analysis, approximately 56.7 million adults aged ≥ 60 years received the vaccine, resulting in 2,954,465 fewer symptomatic RSV-ARI cases over 3 years compared with no vaccination, including 321,019 fewer X-ray confirmed pneumonia cases and 16,660 fewer RSV-related deaths. Vaccination also prevented a substantial number of RSV-related hospitalizations (203,891), emergency department visits (164,060), outpatient visits (1,577,586), and antibiotic prescriptions (1,343,915) over the 3-year period. A considerable public health impact was observed across a range of sensitivity analyses., Conclusions: These findings highlight the potential of the adjuvanted RSVPreF3 vaccine to substantially reduce RSV disease burden among US older adults aged ≥ 60 years., (© 2024. The Author(s).)

Published
2024
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394. Association between adherence to the EAT-Lancet sustainable reference diet and cardiovascular health among European adolescents: the HELENA study.

Author

Cacau LT, Hanley-Cook GT, Vandevijvere S, Leclercq C, De Henauw S, Santaliestra-Pasias A, Manios Y, Mourouti N, Esperanza Díaz L, Gonzalez-Gross M, Widhalm K, Molnar D, Stehle P, Kafatos A, Gottrand F, Kersting M, Castillo M, Lachat C, Marchioni DM, Huybrechts I, and Moreno LA

Subjects
Humans, Adolescent, Body Mass Index, Diet, Healthy, Cholesterol, Diet, Energy Intake
Abstract

Background: The EAT-Lancet Commission proposed a global reference diet to promote healthy diets within planetary boundaries. Studies evaluating the associations between the reference diet with health outcomes among adolescents are scarce. Thus, our aim was to assess the association between adherence to the EAT-Lancet diet and cardiovascular health among European adolescents., Methods: Data from the HELENA study were used. Usual dietary intake was assessed using two 24-h dietary recalls and adherence to the EAT-Lancet diet was assessed using the Planetary Health Diet Index (PHDI), a 16-component index that ranges from 0 to 150 points. Cardiovascular health was assessed through the seven-component Ideal Cardiovascular Health (ICH) score: never smoked, eutrophic body mass index, moderate-to-vigorous physical activity, healthy dietary pattern, low blood pressure, low fasting plasma glucose, and low total cholesterol. Total ICH score was categorized into ideal (5-7) and non-ideal (0-4)., Results: A 10-point increment in the PHDI was associated with a lower probability of a non-ideal ICH status (OR 0.84, [95% CI: 0.75, 0.94]) among European adolescents, after adjusting for age, sex, socio-economic status, and total energy intake. Furthermore, a 10-point increment in the PHDI was associated with lower probability of high blood pressure (OR: 0.87 [0.79, 0.96]) and a lower probability of high blood cholesterol (OR: 0.88 [0.78, 0.99])., Conclusion: Our study suggests that a higher PHDI may be associated with a better cardiovascular health status among European adolescents., (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)

Published
2024
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395. The respiratory syncytial virus prefusion F protein vaccine attenuates the severity of respiratory syncytial virus-associated disease in breakthrough infections in adults ≥60 years of age.

Author

Curran D, Matthews S, Cabrera ES, Pérez SN, Breva LP, Rämet M, Helman L, Park DW, Schwarz TF, Melendez IMG, Schaefer A, Roy N, Stephan B, Molnar D, Kostanyan L, Powers JH 3rd, and Hulstrøm V

Subjects
Humans, Aged, Middle Aged, Breakthrough Infections, Viral Fusion Proteins, Antibodies, Viral, Antibodies, Neutralizing, Respiratory Syncytial Virus Vaccines therapeutic use, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus Infections prevention & control, Respiratory Syncytial Virus, Human, Respiratory Tract Infections, Influenza, Human prevention & control, Influenza, Human drug therapy
Abstract

Background: Respiratory syncytial virus (RSV) is a contagious pathogen causing acute respiratory infections (ARIs). Symptoms range from mild upper respiratory tract infections to potentially life-threatening lower respiratory tract disease (LRTD). In adults ≥60 years old, vaccine efficacy of a candidate vaccine for older adults (RSVPreF3 OA) was 71.7% against RSV-ARI and 82.6% against RSV-LRTD (AReSVi-006/NCT04886596). We present the patient-reported outcomes (PROs) from the same trial at the end of the first RSV season in the northern hemisphere (April 2022)., Methods: In this phase 3 trial, adults aged ≥60 years were randomized (1:1) to receive one dose of RSVPreF3 OA vaccine or placebo. PROs were assessed using InFLUenza Patient-Reported Outcome (FLU-PRO), Short Form-12 (SF-12), and EuroQol-5 Dimension (EQ-5D) questionnaires. Peak FLU-PRO Chest/Respiratory scores during the first 7 days from ARI episode onset were compared using a Wilcoxon test. Least squares mean (LSMean) of SF-12 physical functioning (PF) and EQ-5D health utility scores were estimated using mixed effects models., Results: In the RSVPreF3 OA group ( N  = 12,466), 27 first RSV-ARI episodes were observed versus 95 in the Placebo group ( N  = 12,494). Median peak FLU-PRO Chest/Respiratory scores were lower in RSVPreF3 OA (1.07) versus Placebo group (1.86); p  = 0.0258. LSMean group differences for the PF and EQ-5D health utility score were 7.00 (95% confidence interval [CI]: -9.86, 23.85; p  = 0.4125) and 0.0786 (95% CI: -0.0340, 0.1913; p  = 0.1695)., Conclusions: The RSVPreF3 OA vaccine, in addition to preventing infection, attenuated the severity of RSV-associated symptoms in breakthrough infections, with trends of reduced impact on PF and health utility., Competing Interests: During this study, Eliazar Sabater Cabrera, Desmond Curran, Veronica Hulstrøm, Lusine Kostanyan, and Daniel Molnar were GSK employees. Eliazar Sabater Cabrera, Desmond Curran, Veronica Hulstrøm, Lusine Kostanyan, and Daniel Molnar hold shares in GSK. Isabel Maria Galan Melendez was an investigator for the study of RSV OA‐006 and declares to have received payments from GSK per contract, as well as equipment on loan and study materials. Silvia Narejos Pérez participated as principal investigator (PI) in clinical trials with different sponsors, including GSK and received financial support during the present manuscript. As a PI, she collaborated in the presentation of the results of clinical trials of vaccines and received financial support for attending meetings and/or travel. Laura Helman received payment for completing the study work and was given financial support for attending meetings and/or travel as an investigator. During the development of the study, John H. Powers III was a consultant for GSK and Vir on the clinical study design. Besides that, he received consulting fees from Adaptive Phage, Arrevus, Atheln, Bavarian Nordic, Cellularity, Eicos, Evofem, Eyecheck, Gilead, Mustang, OPKO, Otsuka, Resolve, Romark, Spine BioPharma, and UTIlity. He is an unpaid board member of Health Literacy Media. Mika Rämet declares that his institute was sponsored by GSK to perform the current study. Tino Schwarz has received honoraria for lecturing or advisory boards from Alexion, AstraZeneca, Bavarian Nordic, Biogen, Biontech, CSL Seqirus, GSK, Janssen‐Cilag, Merck‐Serono, Moderna, MSD, Novavax, Pfizer, Roche, Sanofi‐Aventis, and Takeda and for conducting clinical vaccine trials from GSK, Pfizer, Clover Biopharmaceuticals, and Serum Institute of India. Brigitte Stephan participated as investigator in clinical trials with different sponsors, including GSK. Sean Matthews, Lina Pérez Breva, Nathalie Roy, Dae Won Park, and Axel Schaefer have nothing to declare., (© 2024 GSK. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.)

Published
2024
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396. Population trajectories and age-dependent associations of obesity risk factors with body mass index from childhood to adolescence across European regions: A two-cohort study.

Author

Schreuder A, Börnhorst C, Wolters M, Veidebaum T, Tornaritis M, Sina E, Russo P, Moreno LA, Molnar D, Lissner L, De Henauw S, Ahrens W, and Vrijkotte T

Subjects
Child, Humans, Adolescent, Body Mass Index, Cohort Studies, Longitudinal Studies, Risk Factors, Obesity epidemiology, Obesity etiology
Abstract

Objective: To investigate population trajectories of behavioural risk factors of obesity from childhood to adolescence and their associations with body mass index (BMI) in children across European regions., Methods: Data were harmonised between the European multi-centre IDEFICS/I.Family and the Amsterdam Born Children and their Development Cohort. Participants were aged 2.0-9.9 and 5.0-7.5 years at baseline, respectively, and were followed until age 18 years. Behavioural risk factors of interest included diet, physical activity, media use and sleep. Mixed effects models were used for statistical analyses to account for repeated measurements taken from the same child., Results: The study included a total of 14 328 individuals: 4114, 4582, 3220 and 2412 participants from Northern, Southern, Eastern Europe and Amsterdam, respectively. Risk factor means and prevalences changed with age, but the trajectories were mostly similar across regions. Almost no associations between behavioural factors and BMI were found at the age of 6 years. At 11 years, daily sugar-sweetened foods consumption, use of active transport, sports club membership and longer nocturnal sleep duration were negatively associated with BMI in most regions; positive associations were found with media use. Most associations at 11 years of age persisted to 15 years., Conclusions: Whilst population trajectories of media use and nocturnal sleep duration are similar across European regions, those of other behavioural risk factors like active transport and daily vegetable consumption differ. Also, associations between behavioural risk factors and BMI become stronger with age and show similar patterns across regions., (© 2023 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.)

Published
2024
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397. Cost-effectiveness analysis of respiratory syncytial virus vaccination with the adjuvanted prefusion F protein vaccine (RSVPreF3 OA) for adults ≥60 years old in Japan.

Author

Mizukami A, Preckler V, Verelst F, Matsuki T, Ho Y, Kurai D, and Molnar D

Subjects
Humans, Aged, Japan epidemiology, Middle Aged, Aged, 80 and over, Male, Female, Vaccination economics, Viral Fusion Proteins immunology, Quality-Adjusted Life Years, Respiratory Syncytial Virus, Human immunology, Adjuvants, Immunologic economics, Adjuvants, Immunologic administration & dosage, Markov Chains, Cost-Effectiveness Analysis, Cost-Benefit Analysis, Respiratory Syncytial Virus Infections prevention & control, Respiratory Syncytial Virus Infections economics, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus Vaccines economics, Respiratory Syncytial Virus Vaccines administration & dosage, Respiratory Syncytial Virus Vaccines immunology
Abstract

Objectives: Older adults (OA) are at risk of morbidity and mortality from respiratory syncytial virus (RSV), a major cause of seasonal acute respiratory illness. The first RSV vaccine for OA (RSVPreF3 OA) was recently launched in Japan. With the already large and growing OA population in Japan, and limited RSV treatments, prevention is key. The aim of this study was to assess the cost-effectiveness of introducing RSVPreF3 OA for Japanese adults aged ≥60 years., Methods: A static multicohort Markov model was adapted to assess the cost-effectiveness of a single dose of RSVPreF3 OA versus no vaccination over a three-year time horizon. Deterministic and probabilistic sensitivity analyses were conducted to assess parameter uncertainty., Results: RSVPreF3 OA vaccination prevented 1,008,499 cases and 6,840 deaths, with 109,119 quality-adjusted life-years (QALYs) gained. The incremental cost-effectiveness ratio was Japanese yen (JPY) 4,180,084/QALY gained from a payer perspective and JPY 4,041,917/QALY gained from a societal perspective (with productivity loss from RSV disease), thus vaccination was considered cost-effective. Base case results were robust to changes in sensitivity and scenario analyses., Conclusions: RSVPreF3 OA vaccination for adults ≥60 years can provide substantial health benefits and is a cost-effective intervention to reduce the RSV burden in Japan.

Published
2024
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398. The potential public health impact of the respiratory syncytial virus prefusion F protein vaccine in people aged ≥60 years in Japan: results of a Markov model analysis.

Author

Kurai D, Mizukami A, Preckler V, Verelst F, Molnar D, Matsuki T, Ho Y, and Igarashi A

Subjects
Humans, Aged, Japan epidemiology, Public Health, Antibodies, Viral, Respiratory Syncytial Virus Vaccines, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus Infections prevention & control, Respiratory Syncytial Virus, Human
Abstract

Background: Respiratory syncytial virus (RSV), a common respiratory pathogen, can lead to severe symptoms, especially in older adults (OA). A recently developed RSV prefusion F protein (RSVPreF3 OA) vaccine confers high protection against RSV lower respiratory tract disease (LRTD) over two full RSV seasons. The aim of this study was to assess the potential public health impact of RSVPreF3 OA vaccination in the Japanese OA population., Research Design and Methods: A static Markov model was used to estimate the number of symptomatic RSV cases, hospitalizations and deaths in the Japanese population aged ≥ 60 years over a 3-year time horizon. Japan-specific RSV epidemiology and healthcare resource use parameters were used; vaccine efficacy was derived from a phase 3 randomized study (AReSVi-006, NCT04886596). Vaccination coverage was set to 50%., Results: Without vaccination, >5 million RSV acute respiratory illness (ARI) would occur (2.5 million LRTD and 2.8 million upper respiratory tract infections) leading to ~ 3.5 million outpatient visits, >534,000 hospitalizations and ~ 25,500 RSV-related deaths over 3 years. Vaccination could prevent > 1 million RSV-ARI cases, 728,000 outpatient visits, 143,000 hospitalizations and 6,840 RSV-related deaths., Conclusions: RSVPreF3 OA vaccination is projected to have a substantial public health impact by reducing RSV-related morbidity and mortality in the OA population.

Published
2024
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400. Dietary Diversity and Its Association with Diet Quality and Health Status of European Children, Adolescents, and Adults: Results from the I.Family Study.

Author

Dello Russo M, Formisano A, Lauria F, Ahrens W, Bogl LH, Eiben G, De Henauw S, Hebestreit A, Intemann T, Hunsberger M, Lissner L, Molnar D, Pala V, Papoutsou S, Santaliestra-Pasias AM, Veidebaum T, Wolters M, Siani A, and Russo P

Abstract

Dietary diversity (DD) plays a crucial role in fostering high-quality diets, but its association with health outcomes, particularly body adiposity and non-communicable diseases (NCDs), is inconsistent. This may be due to a lack of a standardized method for estimating DD. Our study investigates the association between two DD indices, namely the dietary diversity score (DDS) and food variety score (FVS), and anthropometric measures, biochemical parameters, and diet quality in a large population sample from the I.Family study across research centers in eight European countries. In our cross-sectional analysis of 3035 participants, DDSs varied among countries, with a higher prevalence in the third DDS tertile among those with higher education. DDS showed a positive association with diet quality across all age groups. Higher DDS tertile individuals showed increased fiber, fruit, and vegetable intake, greater meal frequency, and lower ultra-processed food consumption. No relevant biochemical differences were observed across DDS tertiles, and a higher DDS was associated with lower overweight/obesity prevalence only in adults. No significant associations were found with FVS. Our findings emphasize the need to consider food groups for a more accurate estimation of diet quality. This aligns with studies suggesting DDS alone is not an independent risk factor for obesity in children and adolescents. Public health programs should prioritize food diversity to promote improved nutrition and overall well-being in communities.

Published
2023
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