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The article offers information on Wireless wearable sweat biosensors which have gained huge traction due to their potential for noninvasive health monitoring. It mentions Despite intensive research activities, most wearable energy harvesters suffer from complex fabrication procedures, poor robustness, and low power density, making them unsuitable for continuous biosensing.

Polycomb group (PcG) proteins repress master regulators of development and differentiation through organization of chromatin structure. Mutation and dysregulation of PcG genes cause developmental defects and cancer. PcG proteins form condensates in the cell nucleus, and these condensates are the physical sites of PcG-targeted gene silencing via formation of facultative heterochromatin. However, the physiochemical principles underlying the formation of PcG condensates remain unknown, and their determination could shed light on how these condensates compact chromatin. Using fluorescence live-cell imaging, we observed that the Polycomb repressive complex 1 (PRC1) protein chromobox 2 (CBX2), a member of the CBX protein family, undergoes phase separation to form condensates and that the CBX2 condensates exhibit liquid-like properties. Using site-directed mutagenesis, we demonstrated that the conserved residues of CBX2 within the intrinsically disordered region (IDR), which is the region for compaction of chromatin in vitro, promote the condensate formation both in vitro and in vivo.We showed that the CBX2 condensates concentrate DNA and nucleosomes. Using genetic engineering,wereport that trimethylation of Lys-27 at histone H3 (H3K27me3), a marker of heterochromatin formation produced by PRC2, had minimal effects on the CBX2 condensate formation. We further demonstrated that the CBX2 condensate formation does not require CBX2--PRC1 subunits; however, the condensate formation of CBX2--PRC1 subunits depends on CBX2, suggesting a mechanism underlying the assembly of CBX2--PRC1 condensates. In summary, our results reveal that PcG condensates assemble through liquid--liquid phase separation (LLPS) and suggest that phase-separated condensates can organize PcGbound chromatin. [ABSTRACT FROM AUTHOR]

Nanoparticle-mediated intervalence transfer was reported with ferrocene moieties that were attached onto the ruthenium nanoparticle surface by ruthenium-carbene π bonds. The resulting particles exhibited two pairs of voltammetric waves with a potential spacing of about 200 mV and a rather intense absorption peak in the near-infrared range (~1930 nm) at mixed valence. Both features suggested Class II characteristics of the intraparticle intervalence transfer that mainly arose from through-bond interactions between the metal centers. Quantum calculations based on density functional theory showed that the nanoparticle core electrons served as conducting band states for the effective charge delocalization between particle-bound ferrocene moieties. [ABSTRACT FROM AUTHOR]

The article examines the thermodynamics of hydrogen atom transfer (HAT) to a high-valent iron imido complex that is supported by a bulky tris(carbene)-borate ligand. The authors determine the barriers toward electron and proton transfer to calculate the thermodynamic barrier to HAT. They add that the barrier toward proton transfer has been estimated by reaction of LMesFeNAd with a series of acids that differ in their pKa.