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352. Genomic analysis of low‐grade serous ovarian carcinoma to identify key drivers and therapeutic vulnerabilities

Author

Cheasley, Dane, primary, Nigam, Abhimanyu, additional, Zethoven, Magnus, additional, Hunter, Sally, additional, Etemadmoghadam, Dariush, additional, Semple, Timothy, additional, Allan, Prue, additional, Carey, Mark S, additional, Fernandez, Marta L, additional, Dawson, Amy, additional, Köbel, Martin, additional, Huntsman, David G, additional, Le Page, Cécile, additional, Mes‐Masson, Anne‐Marie, additional, Provencher, Diane, additional, Hacker, Neville, additional, Gao, Yunkai, additional, Bowtell, David, additional, deFazio, Anna, additional, Gorringe, Kylie L, additional, and Campbell, Ian G, additional

Published
2020
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354. The Role of Non-Coding RNAs in Uveal Melanoma

Author

Bande, Manuel, primary, Fernandez-Diaz, Daniel, additional, Fernandez-Marta, Beatriz, additional, Rodriguez-Vidal, Cristina, additional, Lago-Baameiro, Nerea, additional, Silva-Rodríguez, Paula, additional, Paniagua, Laura, additional, Blanco-Teijeiro, María José, additional, Pardo, María, additional, and Piñeiro, Antonio, additional

Published
2020
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355. High-flow nasal cannula for Acute Respiratory Distress Syndrome (ARDS) due to COVID-19

Author

Panadero, Carolina, primary, Abad-Fernández, Araceli, additional, Rio-Ramírez, Mª Teresa, additional, Acosta Gutiérrez, Carmen Maria, additional, Calderón-Alcalá, Mariara, additional, López-Riolobos, Cristina, additional, Matesanz-López, Cristina, additional, Garcia-Prieto, Fernando, additional, Diaz-Garcia, Jose Maria, additional, Raboso-Moreno, Beatriz, additional, Vasquez-Gambasica, Zully, additional, Andres-Ruzafa, Pilar, additional, García-Satué, Jose Luis, additional, Calero-Pardo, Sara, additional, Sagastizabal, Belen, additional, Bautista, Diego, additional, Campos, Alfonso, additional, Gonzalez, Marina, additional, Grande, Luis, additional, Jimenez Fernandez, Marta, additional, Santiago-Ruiz, Jose L., additional, Caravaca Perez, Pedro, additional, and Alcaraz, Andres Jose, additional

Published
2020
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356. Treatment of Metastatic Uveal Melanoma: Systematic Review

Author

Rodriguez-Vidal, Cristina, primary, Fernandez-Diaz, Daniel, additional, Fernandez-Marta, Beatriz, additional, Lago-Baameiro, Nerea, additional, Pardo, María, additional, Silva, Paula, additional, Paniagua, Laura, additional, Blanco-Teijeiro, María José, additional, Piñeiro, Antonio, additional, and Bande, Manuel, additional

Published
2020
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359. A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses

Author

Rice, Adrian, primary, Verma, Mohit, additional, Shin, Annie, additional, Zakin, Lise, additional, Sieling, Peter, additional, Tanaka, Shiho, additional, Adisetiyo, Helty, additional, Taft, Justin, additional, Patel, Rosheel, additional, Buta, Sofija, additional, Martin-Fernandez, Marta, additional, Morimoto, Brett, additional, Gabitzsch, Elizabeth, additional, Safrit, Jeffrey T., additional, Balint, Joseph, additional, Dinkins, Kyle, additional, Spilman, Patricia, additional, Bogunovic, Dusan, additional, Rabizadeh, Shahrooz, additional, Niazi, Kayvan, additional, and Soon-Shiong, Patrick, additional

Published
2020
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361. Abstract B23: CDK4/6 and MEK inhibitor combination in low-grade serous ovarian cancer cell lines

Author

Hoenisch, Joshua, primary, Kim, Hannah, additional, Dawson, Amy, additional, Lam, Nicole, additional, Cheasley, Dane A., additional, Gorringe, Kylie, additional, Campbell, Ian, additional, Huntsman, David G., additional, DiMattia, Gabriel, additional, Kobel, Martin, additional, Fernandez, Marta Llaurado, additional, and Carey, Mark S., additional

Published
2020
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362. Multiomics Characterization of Potential Therapeutic Vulnerabilities in Low-grade Serous Ovarian Carcinoma

Author

Shrestha, Raunak, primary, Fernandez, Marta Llaurado, additional, Dawson, Amy, additional, Hoenisch, Joshua, additional, Volik, Stanislav, additional, Lin, Yen-Yi, additional, Anderson, Shawn, additional, Kim, Hannah, additional, Haegert, Anne, additional, Colborne, Shane, additional, McConeghy, Brian, additional, Bell, Robert H., additional, Brahmbhatt, Sonal, additional, DiMattia, Gabriel E., additional, Le Bihan, Stephane, additional, Morin, Gregg B., additional, Collins, Colin C., additional, and Carey, Mark S., additional

Published
2020
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364. MR‐ proADM to detect specific types of organ failure in infection

Author

Andrés, Cristina, primary, Andaluz‐Ojeda, David, additional, Cicuendez, Ramón, additional, Nogales, Leonor, additional, Martín, Silvia, additional, Martin‐Fernandez, Marta, additional, Almansa, Raquel, additional, Calvo, Dolores, additional, Esteban‐Velasco, Maria Carmen, additional, Vaquero‐Roncero, Luis Mario, additional, Ríos‐Llorente, Alberto, additional, Sanchez‐Barrado, Elisa, additional, Muñoz‐Bellvís, Luis, additional, Aldecoa, César, additional, and Bermejo‐Martin, Jesus F., additional

Published
2020
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365. Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions

Author

Martin-Fernandez, Marta, primary, Bravo García-Morato, María, additional, Gruber, Conor, additional, Murias Loza, Sara, additional, Malik, Muhammad Nasir Hayat, additional, Alsohime, Fahad, additional, Alakeel, Abdullah, additional, Valdez, Rita, additional, Buta, Sofija, additional, Buda, Guadalupe, additional, Marti, Marcelo A., additional, Larralde, Margarita, additional, Boisson, Bertrand, additional, Feito Rodriguez, Marta, additional, Qiu, Xueer, additional, Chrabieh, Maya, additional, Al Ayed, Mohammed, additional, Al Muhsen, Saleh, additional, Desai, Jigar V., additional, Ferre, Elise M.N., additional, Rosenzweig, Sergio D., additional, Amador-Borrero, Blanca, additional, Bravo-Gallego, Luz Yadira, additional, Olmer, Ruth, additional, Merkert, Sylvia, additional, Bret, Montserrat, additional, Sood, Amika K., additional, Al-rabiaah, Abdulkarim, additional, Temsah, Mohamad Hani, additional, Halwani, Rabih, additional, Hernandez, Michelle, additional, Pessler, Frank, additional, Casanova, Jean-Laurent, additional, Bustamante, Jacinta, additional, Lionakis, Michail S., additional, and Bogunovic, Dusan, additional

Published
2020
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366. Brain Circuit Alterations and Cognitive Disability in Late-Onset Cobalamin D Disorder

Author

De Las Heras, Javier, primary, Diez, Ibai, additional, Jimenez-Marin, Antonio, additional, Cabrera, Alberto, additional, Ramos-Usuga, Daniela, additional, Diaz-Fernandez, Marta Venecia, additional, Torices, Leire, additional, Nunes-Xavier, Caroline E., additional, Pulido, Rafael, additional, Arango-Lasprilla, Juan Carlos, additional, and Cortes, Jesus M., additional

Published
2020
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367. Hormone receptor expression and outcomes in low-grade serous ovarian carcinoma

Author

Llaurado Fernandez, Marta, primary, Dawson, Amy, additional, Kim, Hannah, additional, Lam, Nicole, additional, Russell, Holly, additional, Bruce, Maegan, additional, Bittner, Madison, additional, Hoenisch, Joshua, additional, Scott, Stephanie A., additional, Talhouk, Aline, additional, Chiu, Derek, additional, Provencher, Diane, additional, Nourmoussavi, Melica, additional, DiMattia, Gabriel, additional, Lee, Cheng-Han, additional, Gilks, C. Blake, additional, Köbel, Martin, additional, and Carey, Mark S., additional

Published
2020
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368. Low-grade serous carcinoma (LGSC): A Canadian multicenter review of practice patterns and patient outcomes

Author

Scott, Stephanie A., primary, Llaurado Fernandez, Marta, additional, Kim, Hannah, additional, Elit, Laurie, additional, Nourmoussavi, Melica, additional, Glaze, Sarah, additional, Roberts, Lesley, additional, Offman, Saul L., additional, Rahimi, Kurosh, additional, Lytwyn, Alice, additional, Sur, Monalisa, additional, Gilks, C. Blake, additional, Matheson, Kara, additional, Köbel, Martin, additional, Dawson, Amy, additional, Tinker, Anna V., additional, Kwon, Janice S., additional, Hoskins, Paul, additional, Santos, Jennifer L., additional, Cheung, Andrea, additional, Provencher, Diane, additional, and Carey, Mark S., additional

Published
2020
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373. JAK Inhibitor Therapy in a Child with Inherited USP18 Deficiency

Author

Alsohime, Fahad, primary, Martin-Fernandez, Marta, additional, Temsah, Mohamad-Hani, additional, Alabdulhafid, Majed, additional, Le Voyer, Tom, additional, Alghamdi, Malak, additional, Qiu, Xueer, additional, Alotaibi, Najla, additional, Alkahtani, Areej, additional, Buta, Sofija, additional, Jouanguy, Emmanuelle, additional, Al-Eyadhy, Ayman, additional, Gruber, Conor, additional, Hasan, Gamal M., additional, Bashiri, Fahad A., additional, Halwani, Rabih, additional, Hassan, Hamdy H., additional, Al-Muhsen, Saleh, additional, Alkhamis, Nouf, additional, Alsum, Zobaida, additional, Casanova, Jean-Laurent, additional, Bustamante, Jacinta, additional, Bogunovic, Dusan, additional, and Alangari, Abdullah A., additional

Published
2020
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374. ISG15 protects human Tregs from interferon alpha‐induced contraction in a cell‐intrinsic fashion

Author

Pacella, Ilenia, primary, Spinelli, Francesca Romana, additional, Severa, Martina, additional, Timperi, Eleonora, additional, Tucci, Gloria, additional, Zagaglioni, Marta, additional, Ceccarelli, Fulvia, additional, Rizzo, Fabiana, additional, Coccia, Eliana M, additional, Patel, Roosheel S, additional, Martin‐Fernandez, Marta, additional, Bogunovic, Dusan, additional, Conti, Fabrizio, additional, Barnaba, Vincenzo, additional, and Piconese, Silvia, additional

Published
2020
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375. De la Gran Madre a la Tealogía. Espiritualidades feministas.

Author

Blanco Fernández, Marta and Blanco Fernández, Marta

Subjects
Masculinity--Religious aspects, Femininity--Religious aspects, Feminist spirituality, Patriarchy--Religious aspects
Abstract

Esta investigación nace a partir de la reflexión sobre la forma de vivir la espiritualidad que tenemos las mujeres occidentales del siglo XXI, partiendo de la base de que, en una cultura como la nuestra, de tradición europea y católica, la divinidad suele ser presentada y vivida en masculino. Podemos referirnos a ella como a un padre, como a un esposo o como a un hijo, sin embargo, no es frecuente conceptualizarla en femenino. Antes, al contrario, la imagen con la que hemos tenido que identificarnos las mujeres a lo largo de los siglos, ha soportado una carga terrible de maldad, pecado, lascivia y lujuria...

Published
2021

376. Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy

Author

Gruber, Conor, primary, Martin-Fernandez, Marta, additional, Ailal, Fatima, additional, Qiu, Xueer, additional, Taft, Justin, additional, Altman, Jennie, additional, Rosain, Jéremie, additional, Buta, Sofija, additional, Bousfiha, Aziz, additional, Casanova, Jean-Laurent, additional, Bustamante, Jacinta, additional, and Bogunovic, Dusan, additional

Published
2019
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379. Current gaps in sepsis immunology: new opportunities for translational research

Author

Rubio, Ignacio, primary, Osuchowski, Marcin F, additional, Shankar-Hari, Manu, additional, Skirecki, Tomasz, additional, Winkler, Martin Sebastian, additional, Lachmann, Gunnar, additional, La Rosée, Paul, additional, Monneret, Guillaume, additional, Venet, Fabienne, additional, Bauer, Michael, additional, Brunkhorst, Frank M, additional, Kox, Matthijs, additional, Cavaillon, Jean-Marc, additional, Uhle, Florian, additional, Weigand, Markus A, additional, Flohé, Stefanie B, additional, Wiersinga, W Joost, additional, Martin-Fernandez, Marta, additional, Almansa, Raquel, additional, Martin-Loeches, Ignacio, additional, Torres, Antoni, additional, Giamarellos-Bourboulis, Evangelos J, additional, Girardis, Massimo, additional, Cossarizza, Andrea, additional, Netea, Mihai G, additional, van der Poll, Tom, additional, Scherag, André, additional, Meisel, Christian, additional, Schefold, Joerg C, additional, and Bermejo-Martín, Jesús F, additional

Published
2019
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380. A new ichthyosaur from the Los Molles Formation (Early Bajocian), Nuequen Basin, Argentina

Author

Fernandez, Marta S.

Subjects
Argentina -- Discovery and exploration, Fishes -- Discovery and exploration, Animals, Fossil -- Identification and classification, Biological sciences, Science and technology
Abstract

A large ichthyosaur from the Los Molles Formation (Early Bajocian) of the Neuquen Basin, Northwestern Patagonia, Argentina, represents a new genus and species, Mollesaurus periallus. The holotype of M. periallus new species represents, along with the type of Chacaicosaurus cayi that was found at the same locality, the only diagnostic ichthyosaur specimens from the Aalenian-Bathonian interval.

Published
1999

382. Chitosan induces differential transcript usage of chitosanase 3 encoding gene (csn3) in the biocontrol fungus Pochonia chlamydosporia 123.

Author

Sambles, Christine, Suarez-Fernandez, Marta, Lopez-Moya, Federico, Lopez-Llorca, Luis Vicente, and Studholme, David J.

Subjects
*CHITOSAN, *POLYMER degradation, *JAVANESE root-knot nematode, *GENETIC engineering, *ENDOPHYTIC fungi
Abstract

Background: Pochonia chlamydosporia is an endophytic fungus used for nematode biocontrol that employs its cellular and molecular machinery to degrade the nematode egg-shell. Chitosanases, among other enzymes, are involved in this process. In this study, we improve the genome sequence assembly of P. chlamydosporia 123, by utilizing long Pacific Biosciences (PacBio) sequence reads. Combining this improved genome assembly with previous RNA-seq data revealed alternative isoforms of a chitosanase in the presence of chitosan. This study could open new insights into understanding fungal resistance to chitosan and root-knot nematode (RKN) egg infection processes. Results: The P. chlamydosporia 123 genome sequence assembly has been updated using long-read PacBio sequencing and now includes 12,810 predicted protein-coding genes. Compared with the previous assembly based on short reads, there are 701 newly annotated genes, and 69 previous genes are now split. Eight of the new genes were differentially expressed in fungus interactions with Meloidogyne javanica eggs or chitosan. A survey of the RNA-seq data revealed alternative splicing in the csn3 gene that encodes a chitosanase, with four putative splicing variants: csn3_v1, csn3_v2, csn3_v3 and csn3_v4. When P. chlamydosporia is treated with 0.1 mg·mL− 1 chitosan for 4 days, csn3 is expressed 10-fold compared with untreated controls. Furthermore, the relative abundances of each of the four transcripts are different in chitosan treatment compared with controls. In controls, the abundances of each transcript are nil, 32, 55, and 12% for isoforms csn3_v1, csn3_v2, csn3_v3 and csn3_v4 respectively. Conversely, in chitosan-treated P. chlamydosporia, the abundances are respectively 80, 15%, 2—3%, 2—3%. Since isoform csn3_v1 is expressed with chitosan only, the putatively encoded enzyme is probably induced and likely important for chitosan degradation. Conclusions: Alternative splicing events have been discovered and described in the chitosanase 3 encoding gene from P. chlamydosporia 123. Gene csn3 takes part in RKN parasitism process and chitosan enhances its expression. The isoform csn3_v1 would be related to the degradation of this polymer in bulk form, while other isoforms may be related to the degradation of chitosan in the nematode egg-shell. [ABSTRACT FROM AUTHOR]

Published
2022
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383. A retrospective investigation of the prodromal stages of eating disorders and use of health services in young patients the year prior to the diagnosis.

Author

Gómez Del Barrio, Andrés, Ruiz Guerrero, Francisco, Benito Gonzalez, Pilar, Perez Fernandez, Marta, Sanchez Blanco, Lucía, Losa Mugica, Edurne, Calcedo Giraldo, Gabriel, and González Gómez, Jana

Subjects
MEDICAL care, EATING disorders, MEDICAL consultation, MEDICAL records, PRIMARY care
Abstract

Aim: The aim of this study was to analyse the characteristics and the frequency of medical consultations in the year prior to the diagnosis and the intervention onset of the Eating Disorder, as well as the different prodromal symptoms. The final aim was to understand the origin of all referrals and their possible influence on the duration of untreated illness. Methods: We selected 99 young patients (15–25 years) and 61 healthy controls. Their primary and specialized care medical records were both studied retrospectively. Results: 87.6% of patients attended different consultations (primary care, specialized care and emergency department) the year prior compared to 67.2% of the controls (p =.002). The average number of consultations was 3.59 in the case group and 1.57 in the control group (p <.001). These consultations were related to prodromal symptoms in 57.4% compared to 16.4% for the controls (p <.001). They ranged from 29.8% of unspecific digestive symptoms, 22.8% of psychological symptoms, 19.3% of gynaecologic symptoms, 11.9% of weight variation, 8.8% of analytical changes, to 5.3% of malnutrition symptoms. Patients were mainly referred by Primary Care (42.7%). Overall, the mean of the Duration of Untreated Illness was of 7.45 months. Conclusions: The majority of reasons for consultation were related to symptoms that could be prodromal symptoms, but the patients were not diagnosed with an eating disorder. These findings highlight the importance of professionals understanding how to identify the warning signs of an eating disorder, so they can refer patients to a specialized unit to establish an early treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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384. Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain.

Author

Delgado-Velandia, Mario, Gonzalez-Marrachelli, Vannina, Domingo-Relloso, Arce, Galvez-Fernandez, Marta, Grau-Perez, Maria, Olmedo, Pablo, Galan, Iñaki, Rodriguez-Artalejo, Fernando, Amigo, Nuria, Briongos-Figuero, Laisa, Redon, Josep, Martin-Escudero, Juan Carlos, Monleon-Salvado, Daniel, Tellez-Plaza, Maria, and Sotos-Prieto, Mercedes

Subjects
LIFESTYLES, CONFIDENCE intervals, METABOLOMICS, CROSS-sectional method, DIET, TYPE 2 diabetes, PHYSICAL activity, HEALTH behavior, ALCOHOL drinking, DESCRIPTIVE statistics, POPULATION health, SMOKING, DATA analysis software, DISEASE risk factors
Abstract

Background: The contribution of metabolomic factors to the association of healthy lifestyle with type 2 diabetes risk is unknown. We assessed the association of a composite measure of lifestyle with plasma metabolite profiles and incident type 2 diabetes, and whether relevant metabolites can explain the prospective association between healthy lifestyle and incident type 2 diabetes. Methods: A Healthy Lifestyle Score (HLS) (5-point scale including diet, physical activity, smoking status, alcohol consumption and BMI) was estimated in 1016 Hortega Study participants, who had targeted plasma metabolomic determinations at baseline examination in 2001–2003, and were followed-up to 2015 to ascertain incident type 2 diabetes. Results: The HLS was cross-sectionally associated with 32 (out of 49) plasma metabolites (2.5% false discovery rate). In the subset of 830 participants without prevalent type 2 diabetes, the rate ratio (RR) and rate difference (RD) of incident type 2 diabetes (n cases = 51) per one-point increase in HLS was, respectively, 0.69 (95% CI, 0.51, 0.93), and − 8.23 (95% CI, − 16.34, − 0.13)/10,000 person-years. In single-metabolite models, most of the HLS-related metabolites were prospectively associated with incident type 2 diabetes. In probit Bayesian Kernel Machine Regression, these prospective associations were mostly driven by medium HDL particle concentration and phenylpropionate, followed by small LDL particle concentration, which jointly accounted for ~ 50% of the HLS-related decrease in incident type 2 diabetes. Conclusions: The HLS showed a strong inverse association with incident type 2 diabetes, which was largely explained by plasma metabolites measured years before the clinical diagnosis. [ABSTRACT FROM AUTHOR]

Published
2022
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385. Influencia de las características y experiencias del alumno y la valoración de los contenidos de la asignatura de Expresión Gráfica

Author

Romero Fernandez, Marta, Universitat Politècnica de Catalunya. Departament d'Expressió Gràfica a l'Enginyeria, Fernández Sánchez, Joaquín, and Villa Sicilia, Ma Arantzazu

Subjects
Enquestes educatives, Matemàtiques i estadística [Àrees temàtiques de la UPC], Educational surveys
Abstract

El objetivo general del proyecto es obtener información estadística sobre las características de los alumnos de la asignatura de Expresión Gráfica (EG) del Grado en Tecnologías Industriales (GETI) y su percepción respecto a la asignatura. También se pretende conocer la percepción de coordinadores de otras asignaturas del GETI de la ETSEIB respecto a los conocimientos que se adquieren en EG. Se realizaron diferentes encuestas mediante plataformas digitales a estudiantes y coordinadores. Sobre los aspectos sociodemográficos, académicos y experiencias previas se realizó la encuesta Caracterización del estudiante (CE). Se les pasó también el Mental Cutting Test (MCT) y se obtuvo su nota de EG. Además, se preguntó tanto a los estudiantes de primero (encuesta TAM1) como a los de cuarto (encuesta TAM4) la percepción que tenían sobre la asignatura de EG. Para valorar la percepción de los coordinadores de otras asignaturas se les pasó la Encuesta 112 sobre competencias y conocimientos adquiridos por los estudiantes. Se hizo un análisis descriptivo de las variables y posteriormente se realizó un estudio de las asociaciones entre ellas. Los resultados principales son que la nota de EG y la nota de MCT tiene una correlación entre ellas y que además pueden depender del sexo del estudiante, si cursó Dibujo Técnico en Bachillerato, si tiene experiencia con programas CAD 3D, el tiempo de desplazamiento a la universidad, la autopercepción de habilidades espaciales (HE) del alumno y la autopercepción de resolución de problemas gráficos del alumno. Además, existe correlación entre las variables, Nota EG-Nota Dibujo Técnico Bachillerato, Nota EGNota 1er cuatrimestre ETSEIB y Nota EG-Nota suspenso de la última convocatoria de los repetidores. Respecto a la percepción del estudiante sobre la asignatura EG, tanto los alumnos de primero como los de cuarto curso del GETI valoran como “Bastante” y “Mucho” los conocimientos adquiridos en EG para resolver problemas geométricos y la utilización de SolidWorks en la asignatura de EG. Además, no hay diferencias significativas entre las respuestas por sexo del alumno en el TAM 1, pero sí que las hay entre alumnos aprobados y suspendidos. Respecto a la valoración de las competencias adquiridas por los coordinadores de otras asignaturas del GETI, opinan que las competencias valoradas como “Bastante” y “Muy importantes” que los estudiantes han adquirido son: “guionizar la presentación oral del diseño”, “capacidad de trabajo en grupo homogéneo” y “capacidad de análisis de problemas”. Respecto a las competencias valoradas como “Muy importantes” opinan que los estudiantes no han adquirido “definir la métrica de los conjuntos de piezas”, “realizar la representación visual en la posición (render estático)” y “capacidad de defensa del proyecto escrito” y de los conocimientos de delineación son “la representación normalizada de escalas”, “la representación normalizada de acotación” y los “conjuntos y despieces”.

Published
2019

386. Influence of Polyacrylamide Hydrogel Stiffness on Podocyte morphology, phenotype and mechanical properties

Author

Abdallah, Maya, Martin Fernandez, Marta, Balme, Sebastien, Cuisinier, Frédéric, Gergely, Csilla, Bassil, Maria, El Tahchi, Mario, Faour, Wissam H., Bechelany, Mikhael, Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM), Laboratoire Charles Coulomb (L2C), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Bioingénierie et NanoSciences (LBN), Université Montpellier 1 (UM1)-Université de Montpellier (UM), and Gergely, Csilla

Subjects
[PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], technology, industry, and agriculture, macromolecular substances
Abstract

International audience; Chronic kidney disease (CKD) is characterized by a gradual decline in renal function that progresses toward end-stage renal disease (ESRD). Podocytes are highly specialized glomerular epithelial cells, which form with the glomerular basement membrane (GBM) and capillary endothelium, the glomerular filtration barrier (GFB). GBM is an extracellular matrix (ECM) that acts as a mechanical support and provides biophysical signals that control normal podocytes behavior in the process of glomerular filtration. Thus the modulus of elasticity E or stiffness of “ECM” represents an essential characteristic that controls podocyte functions. The biophysical properties of hydrolyzed Polyacrylamide (PAAm) gels resemble to in vivo ECM and thus provide an opportunity to be applied as ECM-like membranes to study cellular behaviors. Therefore, hydrolyzed PAAm hydrogels were investigated for their potential use as new ECM-like constructs to engineer a basement membrane that form with cultured human podocytes a functional glomerular-like filtration barrier. Such ECM-like polyacrylamide hydrogel construct will provide the unique opportunity of understanding in an in vivo-like setting podocyte cells biological responses by controlling the physical properties of the PAAm membranes. In this work, several PAAm hydrogel layers were prepared by changing the crosslinker concentration. The macromolecular microstructure and stiffness were evaluated by Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) techniques respectively. Accordingly, the mechanical properties and the polymeric network porosity can be effectively controlled by modulating the crosslinker concentration as well as the swelling degree. Moreover, modulating gel stiffness significantly influenced podocyte behavior including morphology, actin cytoskeleton reorganization. In conclusion, podocytes response to the variation of the mechanical properties of the membranes correlated with the hydrogels stiffness. This work addresses the complexity of podocytes behavior which will further enhance our knowledge to develop a kidney-on-chip model much needed to study kidney function in both health and disease states.

Published
2019

387. IL7RA rs6897932 Polymorphism Is Associated with Better CD4+ T-Cell Recovery in HIV Infected Patients Starting Combination Antiretroviral Therapy

Author

Resino, Salvador, Navarrete-Munoz, Maria A., Blanco, Julia, Pacheco, Yolanda M., Castro, Ivan, Berenguer, Juan, Santos, Jesus, Vera-Mendez, Francisco J., Gorgolas, Miguel, Angeles Jimenez-Sousa, M. A., Benito, Jose M., Rallon, Norma, Moreno, Santiago, Jarrin, Inma, Dalmau, David, Luisa Navarro, Maria, Isabel Gonzalez, Maria, Luis Blanco, Jose, Garcia, Federico, Rubio, Rafael, Antonio Iribarren, Jose, Gutierrez, Felix, Vidal, Francesc, Gonzalez, Juan, Alejos, Belen, Hernando, Victoria, Moreno, Cristina, Iniesta, Carlos, Garcia Sousa, Luis Miguel, Sanz Perez, Nieves, Angeles Munoz-Fernandez, M., Maria Garcia-Merino, Isabel, Consuegra Fernandez, Irene, Gomez Rico, Coral, Gallego de la Fuente, Jorge, Palau Concejo, Paula, Portilla, Joaquin, Merino, Esperanza, Reus, Sergio, Boix, Vicente, Giner, Livia, Gadea, Carmen, Portilla, Irene, Pampliega, Maria, Diez, Marcos, Carlos Rodriguez, Juan, Sanchez-Paya, Jose, Luis Gomez, Juan, Hernandez, Jehovana, Remedios Aleman, Maria, del Mar Alonso, Maria, Inmaculada Hernandez, Maria, Diaz-Flores, Felicitas, Garcia, Dacil, Pelazas, Ricardo, Lopez Lirola, Ana, Sanz Moreno, Jose, Arranz Caso, Alberto, Hernandez Gutierrez, Cristina, Novella Mena, Maria, Pulido, Federico, Bisbal, Otilia, Hernando, Asuncion, Dominguez, Lourdes, Crestelo, David Rial, Bermejo, Laura, Santacreu, Mireia, Arrizabalaga, Julio, Jose Aramburu, Maria, Camino, Xabier, Rodriguez-Arrondo, Francisco, Angel von Wichmann, Miguel, Pascual Tome, Lidia, Angel Goenaga, Miguel, Bustinduy, Ma Jesus, Azkune, Harkaitz, Ibarguren, Maialen, Lizardi, Aitziber, Kortajarena, Xabier, Masia, Mar, Padilla, Sergio, Navarro, Andres, Montolio, Fernando, Robledano, Catalina, Gregori Colome, Joan, Adsuar, Araceli, Pascual, Rafael, Fernandez, Marta, Garcia, Elena, Alberto Garcia, Jose, Barber, Xavier, Lopez Bernaldo de Quiros, Juan Carlos, Gutierrez, Isabel, Ramirez, Margarita, Padilla, Belen, Gijon, Paloma, Aldamiz-Echevarria, Teresa, Tejerina, Francisco, Jose Parras, Francisco, Balsalobre, Pascual, Diez, Cristina, Perez Latorre, Leire, Peraire, Joaquin, Vilades, Consuelo, Veloso, Sergio, Vargas, Montserrat, Lopez-Dupla, Miguel, Olona, Montserrat, Rull, Anna, Rodriguez-Gallego, Esther, Alba, Veronica, Montero Alonso, Marta, Lopez Aldeguer, Jose, Blanes Julia, Marino, Tasias Pitarch, Maria, Castro Hernandez, Ivan, Calabuig Munoz, Eva, Cuellar Tovar, Sandra, Salavert Lleti, Miguel, Fernandez Navarro, Juan, Gonzalez-garcia, Juan, Arnalich, Francisco, Ramon Arribas, Jose, Bernardino de la Serna, Jose Ignacio, Miguel Castro, Juan, Escosa, Luis, Herranz, Pedro, Hontanon, Victor, Garcia-Bujalance, Silvia, Garcia Lopez-Hortelano, Milagros, Gonzalez-Baeza, Alicia, Luz Martin-Carbonero, Maria, Mayoral, Mario, Jose Mellado, Maria, Esteban Mican, Rafael, Montejano, Rocio, Luisa Montes, Maria, Moreno, Victoria, Perez-Valero, Ignacio, Rodes, Berta, Sainz, Talia, Sendagorta, Elena, Stella Alcariz, Natalia, Valencia, Eulalia, Ramon Blanco, Jose, Antonio Oteo, Jose, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Perez-Martinez, Laura, Jaen, Angels, Sanmarti, Montse, Cairo, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemi, Rivero, Maria, Reparaz, Jesus, Ruiz de Alda, Maria Gracia, de Leon Cano, Maria Teresa, Ruiz de Galarreta, Beatriz Pierola, Segura, Ferran, Jose Amengual, Maria, Navarro, Gemma, Sala, Montserrat, Cervantes, Manuel, Pineda, Valentin, Calzado, Sonia, Navarro, Marta, de los Santos, Ignacio, Sanz Sanz, Jesus, Salas Aparicio, Ana, Sarria Cepeda, Cristina, Garcia-Fraile Fraile, Lucio, Martin Gayo, Enrique, Luis Casado, Jose, Dronda, Fernando, Moreno, Ana, Perez Elias, Maria Jesus, Gomez Ayerbe, Cristina, Gutierrez, Carolina, Madrid, Nadia, del Campo Terron, Santos, Marti, Paloma, Ansa, Uxua, Serrano, Sergio, Jesus Vivancos, Maria, Bernal, Enrique, Cano, Alfredo, Alcaraz Garcia, Antonia, Bravo Urbieta, Joaquin, Munoz, Angeles, Jose Alcaraz, Maria, del Carmen Villalba, Maria, Hernandez, Jose, Pena, Alejandro, Munoz, Leopoldo, Casas, Paz, Alvarez, Marta, Chueca, Natalia, Vinuesa, David, Martinez-Montes, Clara, Del Romero, Jorge, Rodriguez, Carmen, Puerta, Teresa, Carlos Carrio, Juan, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Riera, Melchor, Penaranda, Maria, Leyes, Maria, Ribas, Ma Angels, Campins, Antoni A., Vidal, Carmen, Fanjul, Francisco, Murillas, Javier, Homar, Francisco, Gomez Ayerbe, Crisitina, Viciana, Isabel, Palacios, Rosario, Maria Gonzalez, Carmen, Viciana, Pompeyo, Espinosa, Nuria, Fernando Lopez-Cortes, Luis, Podzamczer, Daniel, Ferrer, Elena, Imaz, Arkaitz, Tiraboschi, Juan, Silva, Ana, Saumoy, Maria, Olalla, Julian, del Arco, Alfonso, de la Torre, Javier, Luis Prada, Jose, de Lomas Guerrero, Jose Maria Garcia, Perez Stachowski, Javier, Juan Martinez, Onofre, Jesus Vera, Francisco, Martinez, Lorena, Garcia, Josefina, Alcaraz, Begona, Jimeno, Amaya, Castro Iglesias, Angeles, Pernas Souto, Berta, Mena de Cea, Alvaro, Galera, Carlos, Albendin, Helena, Perez, Aurora, Iborra, Asuncion, Moreno, Antonio, Merlos, Maria Angustias, Vidal, Asuncion, Suarez-Garcia, Ines, Malmierca, Eduardo, Gonzalez-Ruano, Patricia, Martin Rodrigo, Dolores, Ruiz Seco, Ma Pilar, Omar Mohamed-Balghata, Mohamed, Gomez Vidal, Maria Amparo, Estrada Perez, Vicente, Tellez Molina, Maria Jesus, Vergas Garcia, Jorge, Perez-Somarriba Moreno, Juncal, Cabello, Alfonso, Alvarez, Beatriz, Prieto, Laura, Galindo Puerto, Maria Jose, Fernando Vilalta, Ramon, Ferrer Ribera, Ana, Rivero Roman, Antonio, Brieva Herrero, Maria Teresa, Rivero Juarez, Antonio, Lopez Lopez, Pedro, Machuca Sanchez, Isabel, Pena Martinez, Jose, Cervero Jimenez, Miguel, Torres Perea, Rafael, Jusdado Ruiz-Capillas, Juan Jose, Pineda, Juan A., CoRIS HIV Biobank Integrated Spani, Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), European Commission, Resino, Salvador, Castro, Iván, Resino, Salvador [0000-0001-8783-0450], and Castro, Iván [0000-0001-9938-2122]

Subjects
Male, 0301 basic medicine, humanos, lcsh:QR1-502, HIV Infections, Biochemistry, Gastroenterology, lcsh:Microbiology, 0302 clinical medicine, Receptor subunit, Genotype, Hiv infected patients, Drug Interactions, 030212 general & internal medicine, mediana edad, Cd4 t cell, Brief Report, immune reconstitution, Middle Aged, adulto, IL7RA, antirretrovirales, interacciones farmacológicas, Anti-Retroviral Agents, Female, SNPs, Adult, Cart, medicine.medical_specialty, Single-nucleotide polymorphism, cART, Polymorphism, Single Nucleotide, 03 medical and health sciences, Internal medicine, Statistical significance, medicine, Humans, Molecular Biology, Receptors, Interleukin-7, business.industry, HIV, Antiretroviral therapy, CD4, CD4 Lymphocyte Count, recuento de linfocitos CD4, 030104 developmental biology, infecciones por VIH, genotipo, business
Abstract

This article belongs to the Section Molecular Medicine., Interleukin-7 receptor subunit alpha (IL7RA) rs6897932 polymorphism IS related to CD4+ recovery after combination antiretroviral therapy (cART), but no studies so far have analyzed its potential impact in patients with very low CD4+ T-cells count. We aimed to analyze the association between IL7RA rs6897932 polymorphism and CD4+ T-cells count restoration in HIV-infected patients starting combination antiretroviral therapy (cART) with CD4+ T-cells count 20% and was in Hardy–Weinberg equilibrium (p = 0.550). Of 411 patients, 256 carried the CC genotype, while 155 had the CT/TT genotype. The CT/TT genotype was associated with a higher slope of CD4+ T-cells recovery (arithmetic mean ratio; AMR = 1.16; p = 0.016), higher CD4+ T-cells increase (AMR = 1.19; p = 0.004), and higher CD4+ T-cells count at the end of follow-up (AMR = 1.13; p = 0.006). Besides, rs6897932 CT/TT was related to a higher odds of having a value of CD4+ T-cells at the end of follow-up ≥500 CD4+ cells/mm3 (OR = 2.44; p = 0.006). After multiple testing correction (Benjamini–Hochberg), only the increase of ≥ 400 CD4+ cells/mm3 lost statistical significance (p = 0.052). IL7RA rs6897932 CT/TT genotype was related to a better CD4+ T-cells recovery and it could be used to improve the management of HIV-infected patients starting cART with CD4+ T-cells count, This study has been (partially) funded by grants RD12/0017/0031 and D16/0025/0013 to JMB, and RD12/0017/0024 and RD16CIII/0002/0002 to SR as part of the Health Research and Development Strategy, State Plan for Scientific and Technical Research and Innovation (2008–2011; 2013–2016) and co-financed by Institute of Health Carlos III, ISCIII—Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund (ERDF). MA Jiménez-Sousa is funded by project RD16CIII/0002/0002; MA Navarrete-Muñoz is co-funded by RD16/0025/0013 project and Intramural Research Scholarship from IIS-FJD. N Rallón is a Miguel Servet investigator from the ISCIII [grant number CP14/00198].

Published
2019

388. Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis

Author

Fernandez, Marta Llaurado, Dawson, Amy, Hoenisch, Joshua, Kim, Hannah, Bamford, Sylvia, Salamanca, Clara, Dimattia, Gabriel, Shepherd, Trevor, Cremona, Mattia, Hennessy, Bryan, Anderson, Shawn, Volik, Stanislav, Collins, Colin C., Huntsman, David G., and Carey, Mark S.

Subjects
EGFR inhibitor, MEK inhibitor, PKC-alpha, Predictive biomarkers, Ovarian cancer
Abstract

Background: Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as most patients present with advanced disease and current cytotoxic therapies are not overly effective. Recognizing that these cancers may be driven by MAPK pathway activation, MEK inhibitors (MEKi) are being tested in clinical trials. LGSC respond to MEKi only in a subgroup of patients, so predictive biomarkers and better therapies will be needed. Methods: We evaluated a number of patient-derived LGSC cell lines, previously classified according to their MEKi sensitivity. Two cell lines were genomically compared against their matching tumors samples. MEKi-sensitive and MEKi-resistant lines were compared using whole exome sequencing and reverse phase protein array. Two treatment combinations targeting MEKi resistance markers were also evaluated using cell proliferation, cell viability, cell signaling, and drug synergism assays. Results: Low-grade serous ovarian cancer cell lines recapitulated the genomic aberrations from their matching tumor samples. We identified three potential predictive biomarkers that distinguish MEKi sensitive and resistant lines: KRAS mutation status, and EGFR and PKC-alpha protein expression. The biomarkers were validated in three newly developed LGSC cell lines. Sub-lethal combination of MEK and EGFR inhibition showed drug synergy and caused complete cell death in two of four MEKi-resistant cell lines tested. Conclusions: KRAS mutations and the protein expression of EGFR and PKC-alpha should be evaluated as predictive biomarkers in patients with LGSC treated with MEKi. Combination therapy using a MEKi with EGFR inhibition may represent a promising new therapy for patients with MEKi-resistant LGSC.

Published
2019

389. 'Let’s Go Engineering'

Author

Fernandez, Marta, Cabos, Susanna, Roca, Eva, Gimenez, Elsa, and Serrano, Maria

Subjects
Technology and women -- Study and teaching (Primary), Tecnología, Dones i tecnologia -- Educació primària, Desenvolupament humà i sostenible::Desenvolupament humà::Igualtat de gènere [Àrees temàtiques de la UPC], Valores
Abstract

Let’s Go Engineering nace del análisis de la situación actual en España, donde faltan profesionales de la ingeniería para cubrir las necesidades del mercado. Adicionalmente a ésto encontramos la falta de diversidad en el mundo de la ingeniería. Con esto in mente y tras llevar a cabo algunas charlas en centros educativos de Primaria y Secundaria sobre esta problemática, un equipo de Schneider Electric decidió impulsar y desarrollar de forma voluntaria 'Let's Go Engineering', un programa dirigido a estudiantes en últimos cursos de la escuela primaria, cuyo objetivo es colaborar activamente con los centros educativos de las principales ciudades españolas, para crear un espacio de influencia y así contribuir a despertar vocaciones de ingeniería y romper los estereotipos de género asociados a estas carreras. El programa 'Let's Go Engineering' se realiza durante un curso escolar y se compone de varias fases, a lo largo de las cuales se realizan diferentes actividades que pretenden despertar la creatividad de los estudiantes y mostrar el impacto humanitario y beneficio social de la tecnología. Cada clase incluida en el programa se prepara de forma conjunta entre el equipo que integra 'Let's Go Engineering' y el profesorado en las aulas. Además, se hace un acompañamiento a las familias a través de las AMPAs, para que sean conocedores de la realidad, contribuyan a romper estereotipos y sean también agentes del cambio en la mentalidad de las nuevas generaciones. 'Let's Go Engineering', inició el mes de septiembre 2018, con una periodicidad variable de las imparticiones de actividades de entre 15 días y un mes. El programa cuenta con un equipo de más de 40 voluntarios de Schneider Electric y con la colaboración de profesores especializados, universidades públicas como la Universitat Politècnica de Catalunya (UPC), y empresas Partners de Schneider Electric

Published
2019

390. VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients

Author

Jimenez-Sousa, Maria A., Luis Jimenez, Jose, Fernandez-Rodriguez, Amanda, Brochado-Kith, Oscar, Maria Bellon, Jose, Gutierrez, Felix, Diez, Cristina, Bernal-Morell, Enrique, Viciana, Pompeyo, Munoz-Fernandez, Maria A., Resino, Salvador, Moreno, Santiago, del Amo, Julia, Dalmau, David, Luisa Navarro, Maria, Isabel Gonzalez, Maria, Luis Blanco, Jose, Garcia, Federico, Rubio, Rafael, Antonio Iribarren, Jose, Vidal, Francesc, Berenguer, Juan, Gonzalez, Juan, Del Amo, Julia, Jarrin, Inma, Alejos, Belen, Hernando, Victoria, Moreno, Cristina, Iniesta, Carlos, Garcia Sousa, Luis Miguel, Perez, Nieves Sanz, Angeles Munoz-Fernandez, M., Maria Garcia-Merino, Isabel, Consuegra Fernandez, Irene, Gomez Rico, Coral, Gallego de la Fuente, Jorge, Palau Concejo, Paula, Portilla, Joaquin, Merino, Esperanza, Reus, Sergio, Boix, Vicente, Giner, Livia, Gadea, Carmen, Portilla, Irene, Pampliega, Maria, Diez, Marcos, Carlos Rodriguez, Juan, Sanchez-Paya, Jose, Luis Gomez, Juan, Hernandez, Jehovana, Remedios Aleman, Maria, del Mar Alonso, Maria, Inmaculada Hernandez, Maria, Diaz-Flores, Felicitas, Garcia, Dacil, Pelazas, Ricardo, Lopez Lirola, Ana, Sanz Moreno, Jose, Arranz Caso, Alberto, Hernandez Gutierrez, Cristina, Novella Mena, Maria, Pulido, Federico, Bisbal, Otilia, Hernando, Asuncion, Dominguez, Lourdes, Rial Crestelo, David, Bermejo, Laura, Santacreu, Mireia, Arrizabalaga, Julio, Jose Aramburu, Maria, Camino, Xabier, Rodriguez-Arrondo, Francisco, Angel von Wichmann, Miguel, Pascual Tome, Lidia, Angel Goenaga, Miguel, Jesus Bustinduy, Ma, Azkune, Harkaitz, Ibarguren, Maialen, Lizardi, Aitziber, Kortajarena, Xabier, Masia, Mar, Padilla, Sergio, Navarro, Andres, Montolio, Fernando, Robledano, Catalina, Gregori Colome, Joan, Adsuar, Araceli, Pascual, Rafael, Fernandez, Marta, Garcia, Elena, Alberto Garcia, Jose, Barber, Xavier, Bernaldo de Quiros, Juan Carlos Lopez, Gutierrez, Isabel, Ramirez, Margarita, Padilla, Belen, Gijon, Paloma, Aldamiz-Echevarria, Teresa, Tejerina, Francisco, Jose Parras, Francisco, Balsalobre, Pascual, Perez Latorre, Leire, Peraire, Joaquin, Vilades, Consuelo, Veloso, Sergio, Vargas, Montserrat, Lopez-Dupla, Miguel, Olona, Montserrat, Rull, Anna, Rodriguez-Gallego, Esther, Alba, Veronica, Montero Alonso, Marta, Lopez Aldeguer, Jose, Blanes Julia, Marino, Tasias Pitarch, Maria, Castro Hernandez, Ivan, Calabuig Munoz, Eva, Cuellar Tovar, Sandra, Salavert Lleti, Miguel, Fernandez Navarro, Juan, Gonzalez-garcia, Juan, Arnalich, Francisco, Ramon Arribas, Jose, Bernardino de la Serna, Jose Ignacio, Miguel Castro, Juan, Escosa, Luis, Herranz, Pedro, Hontanon, Victor, Garcia-Bujalance, Silvia, Garcia Lopez-Hortelano, Milagros, Gonzalez-Baeza, Alicia, Luz Martin-Carbonero, Maria, Mayoral, Mario, Jose Mellado, Maria, Esteban Mican, Rafael, Montejano, Rocio, Luisa Montes, Maria, Moreno, Victoria, Perez-Valero, Ignacio, Rodes, Berta, Sainz, Talia, Sendagorta, Elena, Stella Alcariz, Natalia, Valencia, Eulalia, Ramon Blanco, Jose, Antonio Oteo, Jose, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Perez-Martinez, Laura, Jaen, Angels, Sanmarti, Montse, Cairo, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemi, Rivero, Maria, Reparaz, Jesus, Ruiz de Alda, Maria Gracia, de Leon Cano, Maria Teresa, Ruiz de Galarreta, Beatriz Pierola, Segura, Ferran, Jose Amengual, Maria, Navarro, Gemma, Sala, Montserrat, Cervantes, Manuel, Pineda, Valentin, Calzado, Sonia, Navarro, Marta, de los Santos, Ignacio, Sanz Sanz, Jesus, Salas Aparicio, Ana, Sarria Cepeda, Cristina, Garcia-Fraile Fraile, Lucio, Martin Gayo, Enrique, Luis Casado, Jose, Dronda, Fernando, Moreno, Ana, Perez Elias, Maria Jesus, Gomez Ayerbe, Cristina, Gutierrez, Carolina, Madrid, Nadia, del Campo Terron, Santos, Marti, Paloma, Ansa, Uxua, Serrano, Sergio, Jesus Vivancos, Maria, Bernal, Enrique, Cano, Alfredo, Alcaraz Garcia, Antonia, Bravo Urbieta, Joaquin, Munoz, Angeles, Jose Alcaraz, Maria, del Carmen Villalba, Maria, Hernandez, Jose, Pena, Alejandro, Munoz, Leopoldo, Casas, Paz, Alvarez, Marta, Chueca, Natalia, Vinuesa, David, Martinez-Montes, Clara, Del Romero, Jorge, Rodriguez, Carmen, Puerta, Teresa, Carlos Carrio, Juan, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Riera, Melchor, Penaranda, Maria, Leyes, Maria, Angels Ribas, Ma, Campins, Antoni A., Vidal, Carmen, Fanjul, Francisco, Murillas, Javier, Homar, Francisco, Santos, Jesus, Gomez Ayerbe, Crisitina, Viciana, Isabel, Palacios, Rosario, Maria Gonzalez, Carmen, Espinosa, Nuria, Fernando Lopez-Cortes, Luis, Podzamczer, Daniel, Ferrer, Elena, Imaz, Arkaitz, Tiraboschi, Juan, Silva, Ana, Saumoy, Maria, Olalla, Julian, del Arco, Alfonso, de la Torre, Javier, Luis Prada, Jose, de Lomas Guerrero, Jose Maria Garcia, Perez Stachowski, Javier, Juan Martinez, Onofre, Jesus Vera, Francisco, Martinez, Lorena, Garcia, Josefina, Alcaraz, Begona, Jimeno, Amaya, Castro Iglesias, Angeles, Pernas Souto, Berta, Mena de Cea, Alvaro, Galera, Carlos, Albendin, Helena, Perez, Aurora, Iborra, Asuncion, Moreno, Antonio, Angustias Merlos, Maria, Vidal, Asuncion, Suarez-Garcia, Ines, Malmierca, Eduardo, Gonzalez-Ruano, Patricia, Martin Rodrigo, Dolores, Omar Mohamed-Balghata, Mohamed, Gomez Vidal, Maria Amparo, Estrada Perez, Vicente, Tellez Molina, Maria Jesus, Vergas Garcia, Jorge, Perez-Somarriba Moreno, Juncal, Gorgolas, Miguel, Cabello, Alfonso, Alvarez, Beatriz, Prieto, Laura, Galindo Puerto, Maria Jose, Fernando Vilalta, Ramon, Ferrer Ribera, Ana, Rivero Roman, Antonio, Brieva Herrero, Maria Teresa, Rivero Juarez, Antonio, Lopez Lopez, Pedro, Machuca Sanchez, Isabel, Pena Martinez, Jose, Cervero Jimenez, Miguel, Torres Perea, Rafael, Jusdado Ruiz-Capillas, Juan Jose, Pineda, Juan A., CoRIS, Spanish HIV HGM BioBank, LTNPs Cohort, Red de Investigación Cooperativa en Investigación en Sida (España), Instituto de Salud Carlos III, and Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)

Subjects
Oncology, medicine.medical_specialty, LTNPs, lcsh:Medicine, Single-nucleotide polymorphism, non-progression, 030312 virology, Calcitriol receptor, 03 medical and health sciences, single nucleotide polymorphisms, Acquired immunodeficiency syndrome (AIDS), Internal medicine, medicine, Vitamin D and neurology, SNP, Allele, 030304 developmental biology, VDR, Non-progression, 0303 health sciences, business.industry, Brief Report, lcsh:R, General Medicine, Odds ratio, Single nucleotide polymorphisms, Acquired immune system, medicine.disease, AIDS, business
Abstract

Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in antiretroviral treatment (ART)-naive HIV-infected patients. Methods: We conducted a retrospective study in 667 HIV-infected patients, who were classified within three groups according to their AIDS progression pattern (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)). Five VDR SNPs (rs11568820, rs4516035, rs2228570, rs1544410, and rs7975232) were genotyped using Agena Bioscience's MassARRAY platform. Results: Significant association results were found for rs2228570. Within all HIV patients, the presence of T allele at VDR rs2228570 SNP was protective against AIDS progression (ordinal outcome) under additive (adjusted odds ratio (aOR) = 0.75; p = 0.009), dominant (aOR = 0.69; p = 0.015), and codominant (aOR = 0.56; p = 0.017) inheritance models. In addition, the same allele was protective under additive and codominant inheritance models when we compared with LTNPs vs. RPs [aOR = 0.64 (p = 0.019) and aOR = 0.37 (p = 0.018), respectively] and when we compared MPs vs. RPs [aOR = 0.72 (p = 0.035) and aOR = 0.45 (p = 0.028), respectively]. Conclusions: The VDR rs2228570 T allele was related to a lower AIDS progression pattern in ART-naive HIV-infected patients. These findings expand upon the knowledge about HIV pathogenesis in untreated HIV-infected patients with different clinical outcomes., This work has been (partially) funded by the RD16/0025/0019 and RD16CIII/0002/0002, projects as part of Accion Estrategica en Salud, Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (2013-2016) and cofinanced by Instituto de Salud Carlos III (Subdireccion General de Evaluacion) and Fondo Europeo de Desarrollo Regional (FEDER), RETIC PT17/0015/0042, Fondo de Investigacion Sanitaria (FIS) (grant number PI16/01863, PI17/01115, PI17CIII/00003), EPIICAL Project and Comunidad de Madrid B2017/BMD-3703. Programa de Investigacion de la Consejeria de Sanidad de la Comunidad de Madrid to JLJ. CIBER-BBN is an initiative funded by the VI National R& D& i Plan 2008-2011, Iniciativa Ingenio 2010, the Consolider Program, and CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. COST CA17140 Cancer Nanomedicine-Front the Bench to Bebside. AFR are supported and funded by Instituto de Salud Carlos III [grant number CP14/0010].

Published
2019

391. What Hotel Owners And Operators Need To Know About Employee Rights Under The FFCRA

Author

Fernandez, Marta

Subjects
Epidemics -- Economic aspects -- United States, Leaves of absence -- Laws, regulations and rules -- Economic aspects, COVID-19 -- Economic aspects -- Laws, regulations and rules, Government regulation, Business, international, Families First Coronavirus Response Act of 2020
Abstract

Frequently Asked Questions or FAQs about employee rights under the Families First Coronavirus Response Act Effective April 1, 2020 and continuing through December 31, 2020, covered employers need to begin [...]

Published
2020

392. Contribution à la sélection de modèle via pénalisation Lasso en Épidémiologie

Author

Avalos Fernandez, Marta, Université de Bordeaux (UB), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Statistics In System biology and Translational Medicine (SISTM), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux, Jérôme Saracco (Jerome.Saracco@math.u-bordeaux1.fr, Président), and Avalos, Marta

Subjects
[STAT.AP]Statistics [stat]/Applications [stat.AP], [STAT.ME] Statistics [stat]/Methodology [stat.ME], [INFO.INFO-LG] Computer Science [cs]/Machine Learning [cs.LG], Model selection, [STAT.CO] Statistics [stat]/Computation [stat.CO], [STAT.ML] Statistics [stat]/Machine Learning [stat.ML], Sélection de modèle, sélection de variables, [STAT.AP] Statistics [stat]/Applications [stat.AP], [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, épidémiologie, epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Lasso, [STAT.CO]Statistics [stat]/Computation [stat.CO], [STAT.ME]Statistics [stat]/Methodology [stat.ME], variable selection
Abstract

Mes travaux portent principalement sur le développement, l’adaptation, l’implémentation et l’application de méthodes statistiques de sélection de modèle. Ma principale contribution consiste à adapter des méthodes de l'apprentissage statistique supervisé qui sont devenues très populaires lors de la dernière décennie, les régressions pénalisées de type Lasso, à l'analyse de données issues d'études épidémiologiques. L'enjeu est de s'attaquer aux problèmes des données volumineuses (\textit{Big Data}) tout en respectant les objectifs et spécificités de la discipline. Le volume important se réfère ici au fait que le nombre d'observations et/ou le nombre de variables est bien plus important que celui qui était classique dans le domaine, sans exclure le cas où le nombre de variables est supérieur au nombre d'observations (données de grande dimension). Le contexte de la pratique épidémiologique est en plein changement avec les évolutions technologiques et la conséquente disponibilité croissante des Big Data. Le Système National des Données de Santé (SNDS), regroupant les principales bases de données de santé publique existantes en France, constitue un exemple de Big Data en santé. Le données ``omiques'' (génomiques, transcriptomiques, protéomiques, métabolomiques, microbiomiques, mycobiomiques, viromiques,$\ldots$) issues des avancées des techniques de séquençage à haut débit constituent un autre exemple de Big Data en santé. Enfin, les mesures de l'\textit{exposome} (par opposition aux facteurs génétiques), qui désigne en épidémiologie l’ensemble des expositions environnementales que subit un individu au long de sa vie peut également constituer une source de Big Data.Ce document s'articule autour de trois chapitres. Il résume mon activité de recherche depuis 2005, soit depuis mon recrutement à l’Université de Bordeaux après ma thèse. Le premier chapitre est une introduction générale dans laquelle je contextualise, motive et énonce la problématique abordée tout au long de mes recherches. Le deuxième chapitre est consacré à mes travaux en lien avec les études sur les traumatismes accidentels et expositions médicamenteuses à partir des données du SNDS. Le troisième chapitre est consacré à mes travaux en lien avec des études biomédicales: la prédiction de la charge virale censurée par un seuil de détection à partir des mutations du VIH, d'une part, et l'automatisation de la détection des seuils d'anomalie des hémogrammes en population générale, d'autre part.

Published
2018

393. Representation Learning of Compositional Data

Author

Avalos Fernandez, Marta, Nock, Richard, Ong, Cheng, Rouar, Julien, Sun, Ke, Statistics In System biology and Translational Medicine (SISTM), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Data61 [Canberra] (CSIRO), Australian National University (ANU)-Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), The University of Sydney, Australian National University (ANU), S. Bengio, H. Wallach, H. Larochelle, K. Grauman, N. Cesa-Bianchi, R. Garnett., and Avalos, Marta

Subjects
PCA, [STAT.AP]Statistics [stat]/Applications [stat.AP], [STAT.ME] Statistics [stat]/Methodology [stat.ME], [INFO.INFO-LG] Computer Science [cs]/Machine Learning [cs.LG], Compositional data, Relative abundance data, [STAT.CO] Statistics [stat]/Computation [stat.CO], Bregman divergences, [STAT.ML] Statistics [stat]/Machine Learning [stat.ML], [STAT.AP] Statistics [stat]/Applications [stat.AP], [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [STAT.CO]Statistics [stat]/Computation [stat.CO], [STAT.ME]Statistics [stat]/Methodology [stat.ME], Microbiome data
Abstract

International audience; We consider the problem of learning a low dimensional representation for compositional data. Compositional data consists of a collection of nonnegative data that sum to a constant value. Since the parts of the collection are statistically dependent, many standard tools cannot be directly applied. Instead, compositional data must be first transformed before analysis. Focusing on principal component analysis (PCA), we propose an approach that allows low dimensional representation learning directly from the original data. Our approach combines the benefits of the log-ratio transformation from compositional data analysis and exponential family PCA. A key tool in its derivation is a generalization of the scaled Bregman theorem, that relates the perspective transform of a Bregman divergence to the Bregman divergence of a perspective transform and a remainder conformal divergence. Our proposed approach includes a convenient surrogate (upper bound) loss of the exponential family PCA which has an easy to optimize form. We also derive the corresponding form for nonlinear autoencoders. Experiments on simulated data and microbiome data show the promise of our method.

Published
2018

394. How should we approach prescribing for persistent pain in primary care?

Author

Fulthorpe, Francesca, Mosaheb, Rishi, Czernicki, Michal, and Fernandez, Marta

Subjects
PHYSICIAN-patient relations, IMMUNOCOMPROMISED patients, MEDICATION therapy management, PRIMARY health care, DRUG prescribing, DECISION making, COMMUNICATION, QUALITY of life, PHYSICIAN practice patterns, OPIOID analgesics, PAIN management
Published
2023
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396. Molecular Mechanisms of Chitosan Interactions with Fungi and Plants

Author

Universidad de Alicante. Departamento de Ciencias del Mar y Biología Aplicada, Universidad de Alicante. Instituto Multidisciplinar para el Estudio del Medio "Ramón Margalef", Lopez-Moya, Federico, Suarez-Fernandez, Marta, Lopez-Llorca, Luis Vicente, Universidad de Alicante. Departamento de Ciencias del Mar y Biología Aplicada, Universidad de Alicante. Instituto Multidisciplinar para el Estudio del Medio "Ramón Margalef", Lopez-Moya, Federico, Suarez-Fernandez, Marta, and Lopez-Llorca, Luis Vicente

Abstract

Chitosan is a versatile compound with multiple biotechnological applications. This polymer inhibits clinically important human fungal pathogens under the same carbon and nitrogen status as in blood. Chitosan permeabilises their high-fluidity plasma membrane and increases production of intracellular oxygen species (ROS). Conversely, chitosan is compatible with mammalian cell lines as well as with biocontrol fungi (BCF). BCF resistant to chitosan have low-fluidity membranes and high glucan/chitin ratios in their cell walls. Recent studies illustrate molecular and physiological basis of chitosan-root interactions. Chitosan induces auxin accumulation in Arabidopsis roots. This polymer causes overexpression of tryptophan-dependent auxin biosynthesis pathway. It also blocks auxin translocation in roots. Chitosan is a plant defense modulator. Endophytes and fungal pathogens evade plant immunity converting chitin into chitosan. LysM effectors shield chitin and protect fungal cell walls from plant chitinases. These enzymes together with fungal chitin deacetylases, chitosanases and effectors play determinant roles during fungal colonization of plants. This review describes chitosan mode of action (cell and gene targets) in fungi and plants. This knowledge will help to develop chitosan for agrobiotechnological and medical applications.

Published
2019

397. The Making of an Imperial Agricultural Landscape in the valley of Belén

Author

European Commission, Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Ministère de l'Europe et des Affaires étrangères (France), González-García, A. César, Saintenoy, Thibault, Crespo Fernandez, Marta, European Commission, Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Ministère de l'Europe et des Affaires étrangères (France), González-García, A. César, Saintenoy, Thibault, and Crespo Fernandez, Marta

Abstract

Agricultural planning is not limited to works of terracing, land allotment and hydraulic engineering. As a collective social practice, agriculture also requires the formalization of a corporate coordination system, based on devices such as calendars and ceremonies, which relate the collective of farmers with the space-time of agricultural practice in a given socio-economic and political context. We present an unusual architectural structure located in the Altos de Arica (south-central Andes), whose circular shape and combination of windows and niches echo the characteristics of a special Inca building of Cuzco¿s main square: the sunturhuasi. By means of a 3D multiscale modelling-based simulation, we demonstrate the landscape and astronomical potential of this architecture. The results are consistent with ethno-historical information about the Inca agricultural calendar and related astronomical observation practices. Taking into account the local archaeological context, we suggest that this special architecture constituted a central stage of an imperial built environment related to the political economy of maize production.

Published
2019

398. The making of an imperial agricultural landscape in the Valley of Belén

Author

Ministère de l'Europe et des Affaires étrangères (France), Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), European Commission, Saintenoy, Thibault [0000-0001-8941-2164], González-García, A. César [0000-0003-1831-8562], Saintenoy, Thibault, González-García, A. César, Crespo Fernandez, Marta, Ministère de l'Europe et des Affaires étrangères (France), Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), European Commission, Saintenoy, Thibault [0000-0001-8941-2164], González-García, A. César [0000-0003-1831-8562], Saintenoy, Thibault, González-García, A. César, and Crespo Fernandez, Marta

Abstract

As the Inca Empire was predominantly agrarian, the integration of local farming communities into a corporate agricultural system constituted a great challenge for the imperial political economy. The authors thus analyse an unusual circular structure in the Altos de Arica region of northern Chile, which resembles an important building - called 'sunturhuasi' - in the capital, Cusco. They explore this structure using three-dimensional modelling, identifying its probable use in astronomical observations and hence its clear connection with the Inca agricultural calendar, ultimately suggesting that it was central to an imperial built environment related to the political economy of maize production.

Published
2019

399. Incahullo_Sunturwasi dataset

Author

Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Ministère de l'Europe et des Affaires étrangères (France), European Commission, Saintenoy, Thibault, Crespo Fernandez, Marta, González-García, A. César, Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Ministère de l'Europe et des Affaires étrangères (France), European Commission, Saintenoy, Thibault, Crespo Fernandez, Marta, and González-García, A. César

Abstract

3D model of an Inca building generated from a multi-scale photogrammetric survey, anchored to a digital elevation model (DEM) “Advanced Elevation Serie 4m” of the study area, georeferenced after the Chilean geodetic network; horizon from the centre of the building generated from the same DEM ; archaeo-astronomical simulation to be run with the Scenery 3D plug-in of Stellarium software.

Published
2019

400. Influencia de las características y experiencias del alumno y la valoración de los contenidos de la asignatura de Expresión Gráfica

Author

Universitat Politècnica de Catalunya. Departament d'Expressió Gràfica a l'Enginyeria, Fernández Sánchez, Joaquín, Villa Sicilia, Ma Arantzazu, Romero Fernandez, Marta, Universitat Politècnica de Catalunya. Departament d'Expressió Gràfica a l'Enginyeria, Fernández Sánchez, Joaquín, Villa Sicilia, Ma Arantzazu, and Romero Fernandez, Marta

Abstract

El objetivo general del proyecto es obtener información estadística sobre las características de los alumnos de la asignatura de Expresión Gráfica (EG) del Grado en Tecnologías Industriales (GETI) y su percepción respecto a la asignatura. También se pretende conocer la percepción de coordinadores de otras asignaturas del GETI de la ETSEIB respecto a los conocimientos que se adquieren en EG. Se realizaron diferentes encuestas mediante plataformas digitales a estudiantes y coordinadores. Sobre los aspectos sociodemográficos, académicos y experiencias previas se realizó la encuesta Caracterización del estudiante (CE). Se les pasó también el Mental Cutting Test (MCT) y se obtuvo su nota de EG. Además, se preguntó tanto a los estudiantes de primero (encuesta TAM1) como a los de cuarto (encuesta TAM4) la percepción que tenían sobre la asignatura de EG. Para valorar la percepción de los coordinadores de otras asignaturas se les pasó la Encuesta 112 sobre competencias y conocimientos adquiridos por los estudiantes. Se hizo un análisis descriptivo de las variables y posteriormente se realizó un estudio de las asociaciones entre ellas. Los resultados principales son que la nota de EG y la nota de MCT tiene una correlación entre ellas y que además pueden depender del sexo del estudiante, si cursó Dibujo Técnico en Bachillerato, si tiene experiencia con programas CAD 3D, el tiempo de desplazamiento a la universidad, la autopercepción de habilidades espaciales (HE) del alumno y la autopercepción de resolución de problemas gráficos del alumno. Además, existe correlación entre las variables, Nota EG-Nota Dibujo Técnico Bachillerato, Nota EGNota 1er cuatrimestre ETSEIB y Nota EG-Nota suspenso de la última convocatoria de los repetidores. Respecto a la percepción del estudiante sobre la asignatura EG, tanto los alumnos de primero como los de cuarto curso del GETI valoran como “Bastante” y “Mucho” los conocimientos adquiridos en EG para resolver problemas geométricos y la utilización

Published
2019

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