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В период с 5 по 9 сентября 2022 г. в Женеве по инициативе Российской Федерации в соответствии со статьей IV Конвенции о запрещении разработки, производства и накопления запасов бактериологического (биологического) и токсинного оружия и об их уничтожении (КБТО) состоялось Консультативное совещание государств-участников КБТО. По итогам мероприятия делегациями был принят доклад, не снимающий озабоченности Российской Федерации по вопросам, касающимся нарушений КБТО на территории Украины. Данное обстоятельство предопределило необходимость продвижения российских инициатив по укреплению механизма соблюдения КБТО путем принятия протокола к Конвенции, определяющего механизмы проверки, а также по созданию Научно- консультативного комитета КБТО и расширению мер укрепления доверия.

The GEp-III and GEp-2γ experiments, carried out in Jefferson Lab's Hall C from 2007–2008, consisted of measurements of polarization transfer in elastic electron–proton scattering at momentum transfers of Q2=2.5,5.2,6.8, and 8.54 GeV 2. These measurements were carried out to improve knowledge of the proton electromagnetic form factor ratio R=μpGEp∕GMp at large values of Q2 and to search for effects beyond the Born approximation in polarization transfer observables at Q2=2.5GeV2. The final results of both experiments were reported in a recent archival publication. A full reanalysis of the data from both experiments was carried out in order to reduce the systematic and, for the GEp-2γ experiment, statistical uncertainties. This technical note provides additional details of the final analysis omitted from the main publication, including the final evaluation of the systematic uncertainties.

The GEp-III and GEp-2γ experiments, carried out in Jefferson Lab's Hall C from 2007–2008, consisted of measurements of polarization transfer in elastic electron–proton scattering at momentum transfers of Q2=2.5,5.2,6.8, and 8.54 GeV 2. These measurements were carried out to improve knowledge of the proton electromagnetic form factor ratio R=μpGEp∕GMp at large values of Q2 and to search for effects beyond the Born approximation in polarization transfer observables at Q2=2.5GeV2. The final results of both experiments were reported in a recent archival publication. A full reanalysis of the data from both experiments was carried out in order to reduce the systematic and, for the GEp-2γ experiment, statistical uncertainties. This technical note provides additional details of the final analysis omitted from the main publication, including the final evaluation of the systematic uncertainties.

Subsequent to the release of our original paper, we discovered in the context of preparing our technical supplement [1] for journal publication that a typographical error had existed in the text file that the analysis program used to construct the beam polarization "database" for both the original analysis, published in Ref. [2], and our final analysis. The electron-beam polarization P e and the analyzing power A y cancel exactly in the ratio R , which is proportional to the ratio P t / P l of the transferred polarization components. On the other hand, the extraction of the relative e dependence of P l / P Born l relies on knowledge of the beam polarization. As such, data taking was interrupted roughly every two days during the GEp - 2 ? experiment to perform invasive measurements of the beam polarization using the Hall C Moller polarimeter [3]. The run range affected by the typographical error was entirely contained within the data collected at Q 2 = 2.5 GeV 2 with a beam energy of E e = 3.680 GeV during January 2008. The data from this configuration were combined with the data collected at E e = 3.548 GeV due to the nearly complete overlap of these two settings in terms of Q 2 and e acceptance. It is worth remarking that this typographical error went unnoticed for so long because it only affected a small fraction of the data (less than half of the combined data for ? e ? = 0.790 ) and the difference between the actually assigned beam polarization and the polarization that should have been assigned was comparable in magnitude to the point-to-point systematic uncertainty of the measurement itself. As such, its effect did not show up in various diagnostic plots and statistical tests, such as the time stability of the extracted P l / P Born l ratio. The data for both E e = 3.548 and E e = 3.680 GeV were reprocessed using the corrected beam polarizations to determine the effect of the typographical error on the combined physics results at ? e ? = 0.790 . Because the value of P e cancels in the ratio R , changes in the assumed beam polarization can only affect the results for R via statistical fluctuations due to changes in the relative weighting of different run ranges in the unbinned maximum-likelihood estimators for R . These effects are negligible on the scale of both the statistical and the systematic uncertainties of the data. More noticeable changes are expected in the ratio P l / P Born l since the extracted value of P l is inversely proportional to the assumed value of P e . Table I shows the effect of the corrected beam polarization database on the polarization transfer observables for the combined data for the ? e ? = 0.790 setting, the only measurement affected by the typographical error. The analyzing power did not need to be recalibrated since it was determined using the ? e ? = 0.153 data, which were not affected by the typographical error. As expected, the change in the ratio R is negligible. The value of P Born l , which is computed event by event from the global fit described in the Appendix of the original paper and does not depend on P e , is also unchanged. The magnitudes of P t , P l , and P l / P Born l are reduced by a common multiplicative factor, reflecting the fact that the beam polarization had been underestimated for the run range affected by the typographical error. The most important result of the corrected analysis is that the ratio P l / P Born l has decreased by 0.0024 from 1.0167 to 1.0143, a change comparable in magnitude to the statistical uncertainty but small compared to the total and point-to-point systematic uncertainties. The P l / P Born l result for the original publication [2] would be reduced by the same multiplicative factor as the final result. The physics conclusions of both publications are not materially changed by this correction. (Table Presented). (Figure Presented).

Subsequent to the release of our original paper, we discovered in the context of preparing our technical supplement [1] for journal publication that a typographical error had existed in the text file that the analysis program used to construct the beam polarization "database" for both the original analysis, published in Ref. [2], and our final analysis. The electron-beam polarization P e and the analyzing power A y cancel exactly in the ratio R , which is proportional to the ratio P t / P l of the transferred polarization components. On the other hand, the extraction of the relative e dependence of P l / P Born l relies on knowledge of the beam polarization. As such, data taking was interrupted roughly every two days during the GEp - 2 ? experiment to perform invasive measurements of the beam polarization using the Hall C Moller polarimeter [3]. The run range affected by the typographical error was entirely contained within the data collected at Q 2 = 2.5 GeV 2 with a beam energy of E e = 3.680 GeV during January 2008. The data from this configuration were combined with the data collected at E e = 3.548 GeV due to the nearly complete overlap of these two settings in terms of Q 2 and e acceptance. It is worth remarking that this typographical error went unnoticed for so long because it only affected a small fraction of the data (less than half of the combined data for ? e ? = 0.790 ) and the difference between the actually assigned beam polarization and the polarization that should have been assigned was comparable in magnitude to the point-to-point systematic uncertainty of the measurement itself. As such, its effect did not show up in various diagnostic plots and statistical tests, such as the time stability of the extracted P l / P Born l ratio. The data for both E e = 3.548 and E e = 3.680 GeV were reprocessed using the corrected beam polarizations to determine the effect of the typographical error on the combined physics results at ? e ? = 0.790 . Because the value of P e cancels in the ratio R , changes in the assumed beam polarization can only affect the results for R via statistical fluctuations due to changes in the relative weighting of different run ranges in the unbinned maximum-likelihood estimators for R . These effects are negligible on the scale of both the statistical and the systematic uncertainties of the data. More noticeable changes are expected in the ratio P l / P Born l since the extracted value of P l is inversely proportional to the assumed value of P e . Table I shows the effect of the corrected beam polarization database on the polarization transfer observables for the combined data for the ? e ? = 0.790 setting, the only measurement affected by the typographical error. The analyzing power did not need to be recalibrated since it was determined using the ? e ? = 0.153 data, which were not affected by the typographical error. As expected, the change in the ratio R is negligible. The value of P Born l , which is computed event by event from the global fit described in the Appendix of the original paper and does not depend on P e , is also unchanged. The magnitudes of P t , P l , and P l / P Born l are reduced by a common multiplicative factor, reflecting the fact that the beam polarization had been underestimated for the run range affected by the typographical error. The most important result of the corrected analysis is that the ratio P l / P Born l has decreased by 0.0024 from 1.0167 to 1.0143, a change comparable in magnitude to the statistical uncertainty but small compared to the total and point-to-point systematic uncertainties. The P l / P Born l result for the original publication [2] would be reduced by the same multiplicative factor as the final result. The physics conclusions of both publications are not materially changed by this correction. (Table Presented). (Figure Presented).

The relevance of the article is conditioned by the exceptional importance of the social infrastructure for the development of the state, society and each individual. Social infrastructure ensures the development of the municipal unit, satisfaction of the basic needs and interests of the population, creation of the conditions for its subsistence and reproduction. In this connection, the paper aims at analysis of the main challenges and tendencies in the functioning of the social infrastructure of the Russian territories, the factors of its development. The major method of research is jury of opinion--the leaders of local authorities, that has allowed to consider the main resources and restrictions of their activities for the development of social infrastructure in the modern Russian conditions. The article includes the analysis of factors, determining the effectiveness of the development of social infrastructure of municipal units in the Russian Federation. The work discloses the financial-and-economic and political factors, limiting the development of territorial social infrastructure. The article proves that the socio-cultural factors can serve as resources of formation of investment attractiveness of the territory, the development of social infrastructure. The results of the research can be used in the activity of public authorities in drafting of regulations, the practice of local government, contributing to the development of social infrastructure.

The relevance of the research is conditioned by the need to win the competition struggle by certain organizations and area in general. Education has recently become very popular for the training of highly professional staff. However, achieving this goal is possible by means of creation of favorable working and learning conditions, maintaining health of the teaching staff and students. Therefore, the present article has the purpose to reveal the issues of monitoring of working conditions and the nature of their influence on the health of students and academic staff of Russian State Social University (RSSU). The main approach, implemented in the study has been the system one, giving the opportunity to study the problem in the logical relationship. Also, there has been used the method of comparative analysis, based on the comparison of the results of content analysis of documentary data of the university and sociological survey. The paper reveals the nature of the impact of working conditions on the health of students and teaching staff. There is a dependence of the increase in the incidence of the academic staff and the duration of the university renewal. Scientific and methodological recommendations for the formation of working and learning conditions, favorable for health of students and professors have been working out.

Abstract Current trends in the application of bioindication methods are related to the use of submersible tools that perform real‐time measurements directly in the studied aquatic environment. The methods based on the registration of changes in the behavioral responses of zooplankton, in particular Crustaceans, which make up the vast majority of the biomass in water areas, seem quite promising. However, the multispecies composition of natural planktonic biocenoses poses the need to consider the potential difference in the sensitivity of organisms to pollutants. This paper describes laboratory studies of the phototropic response of plankton to attracting light. The studies were carried out on a model natural community that in equal amounts includes Daphnia magna, Daphnia pulex, and Cyclops vicinus, as well as on the monoculture groups of these species. The phototropic response was initiated by the attracting light with a wavelength of 532 nm close to the local maximum of the reflection spectrum of chlorella microalgae. Standard potassium bichromate was used as the model pollutant. The largest phototropic response value is registered in the assemblage. The concentration growth rate of crustaceans in the illuminated volume was 4.5 ± 0.3 ind (L min)−1. Of the studied species, the phototropic response was mostly expressed in Daphnia magna (3.7 ± 0.4 ind (L min)−1), while in Daphnia pulex, it was reduced to 2.4 ± 0.2 ind (L min)−1, and in Cyclops vicinus, it was very small—0.16 ± 0.02 ind (L min)−1. This is caused by peculiar trophic behavior of phyto‐ and zoophages. The addition of a pollutant, namely potassium bichromate, caused a decrease in the concentration rate of crustaceans in the attracting light zone, while a dose‐dependent change in phototropic responses was observed in a group of species and the Daphnia magna assemblage. The results of laboratory studies showed high potential of using the phototropic response of zooplankton to monitor the quality of its habitat thus ensuring the early diagnostics of water pollution. Besides, the paper shows the possibility of quantifying the phototropic response of zooplankton using submersible digital holographic cameras (DHC).

This paper describes the results of studying the waves in the southern part of the Sea of Okhotsk on the sea routes between Sakhalin and Iturup islands by means of autonomous wave recorders. The study was performed in order to improve the safety of the maritime transport system and ensure its safe functioning. Analysis of the wave regime and weather conditions in the southern part of the Sea of Okhotsk, has shown that a cyclone of any direction approaching the southern part of the Sea of Okhotsk, causes sea waves with heights of more than 1.7 meters in the considered water area and nearshore of Iturup Island. However, if a cyclone approaches Sakhalin Island from the northwest direction, the height of wind waves and swell in the coastal area of the southeast of the island is small, and here is an opportunity for ships to take shelter from the storm. The analysis of long waves with tidal harmonic periods of 4 hours and more has shown, that they have almost the same oscillation phase for both islands. The internal waves caused by the local features of bathymetry and relief of the coastal zone for each adjacent water area are analyzed. Surface gravitational waves with a period of about 2.8 hours were detected at Kuibyshevsky and Kurilsky bays, and waves with a period of 2.4 hours were detected near the Okhotskoye village at Sakhalin Island. It is shown that the highest Q-factor in the Kurilsk region has the resonant water area for the periods of 4.5 minutes. It is noted that for these waves the phenomenon of a tyagun (harbour oscillations) can be expected during a storm at sea.

Intramuscularly administered vaccines stimulate robust serum neutralizing antibodies, yet they are often less competent in eliciting sustainable “sterilizing immunity” at the mucosal level. Our study uncovers a strong temporary neutralizing mucosal component of immunity, emanating from intramuscular administration of an mRNA vaccine. We show that saliva of BNT162b2 vaccinees contains temporary IgA targeting the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus-2 spike protein and demonstrate that these IgAs mediate neutralization. RBD-targeting IgAs were found to associate with the secretory component, indicating their bona fide transcytotic origin and their polymeric multivalent nature. The mechanistic understanding of the high neutralizing activity provided by mucosal IgA, acting at the first line of defense, will advance vaccination design and surveillance principles and may point to novel treatment approaches and new routes of vaccine administration and boosting.