301. Role Of Supraspinal α1-Adrenoceptors For Voiding In Conscious Rats With And Without Bladder Outlet Obstruction
- Author
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Bao Jun Gu, Karl-Erik Andersson, Yasuhiko Igawa, Osamu Ishizuka, and Osamu Nishizawa
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Urology ,Central nervous system ,Cystometry ,Adrenergic ,urologic and male genital diseases ,α1 adrenoceptor ,female genital diseases and pregnancy complications ,Neck of urinary bladder ,Terazosin ,Bladder outlet obstruction ,medicine.anatomical_structure ,Endocrinology ,Internal medicine ,medicine ,Prazosin ,business ,medicine.drug - Abstract
Purpose: Previous studies have shown that spinal α1-adrenoceptors can influence voiding in normal rats and in rats with outlet obstruction. Also, at the supraspinal level such receptors may be involved in voiding control. Therefore, we studied in rats the effects on cystometrography of intracerebroventricular administered α1-adrenoceptor antagonists.Materials and Methods: Continuous cystometry was performed in conscious, freely moving rats with and without bladder outlet obstruction. Cystometric parameters were evaluated before and after intracerebroventricular drug administration.Results: In normal rats intracerebroventricular administration of 8 nmol. kg.−1 prazosin (Pfizer Central Research, Sandwich, United Kingdom) or terazosin (Abbott Laboratories, Abbott Park, Illinois) (nonsubtype selective) caused no change in cystometric parameters. At 24 or 80 nmol. kg.−1 the 2 drugs significantly decreased voiding pressure and increased bladder capacity, voided volume and post-void residual urine volume. Admini...
- Published
- 2002