INTRAVESICAL OXYHEMOGLOBIN INITIATES BLADDER OVERACTIVITY IN CONSCIOUS, NORMAL RATS

Authors :: Karl-Erik Andersson
Raj Kumar Pandita
Hiroya Mizusawa
Source :: Journal of Urology. 164:545-550
Publication Year :: 2000
Publisher :: Ovid Technologies (Wolters Kluwer Health), 2000.
Abstract: Purpose: To investigate whether intravesical oxyhemoglobin, a nitric oxide scavenger, changes bladder activity in normal rats.Materials and Methods: Oxyhemoglobin was given intravesically at different concentrations to conscious, female Sprague-Dawley rats undergoing continuous cystometry.Results: Intravesical oxyhemoglobin increased bladder activity in a concentration-dependent way. At a concentration of 2.5 × 10−4 M (n = 8), micturition pressure (p

Subjects :: medicine.medical_specialty
medicine.diagnostic_test
business.industry
Urology
media_common.quotation_subject
Cystometry
Bladder capacity
Urination
Nitric oxide
Basal (phylogenetics)
chemistry.chemical_compound
chemistry
Micturition volume
Toxicity
medicine
business
media_common
Guanylate cyclase

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