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Climate change has an indirect effect on water quality in freshwater ecosystems, but it is difficult to assess the contribution of climate change to the complex system. This study explored to what extent climatic indicators (air temperature, wind speed, and rainfall) influence nutrients and oxygen levels in a shallow reservoir, Yuqiao Reservoir, China. The study comprises three parts—describing the temporal trends of climatic indicators and water quality parameters during the period 1992-2011, analyzing the potential impacts of climate on water quality, and finally developing a quantitative assessment to evaluate how climatic factors govern nutrient levels in the reservoir. Our analyses showed that the reservoir experienced substantial cold periods (1992-2001) followed by a warm period (2002-2011). The results showed that increasing air temperature in spring, autumn, and winter and increasing annual wind speed decrease total phosphorus (TP) concentration in the reservoir in spring, summer, and winter. According to the quantitative assessment, the increase in air temperature in spring and winter had a larger contribution to the decrease in TP concentration (47.2 and 64.1%), compared with the influence from decreased wind speed and rainfall. The field data suggest that nutrients decline due to enhanced uptake by macrophytes in years when spring was warmer and the macrophytes started to grow earlier in the season. The increasing wind speed and air temperature in spring also significantly contribute to the increase in dissolved oxygen concentration. This study helps managers to foresee how potential future climate change might influence water quality in similar lake ecosystems. [ABSTRACT FROM AUTHOR]

A new simple and continuous method was developed for chemically grafting multi-wall carbon nanotubes (MWCNTs) onto the surface of carbon fibers (CF) to improve the interlaminar properties of composites. In this method, maleimide-grafted waterborne polyurethane emulsion and furan functionalized MWCNTs were prepared. Then, based on the Diels-Alder reaction under mild reaction conditions (60 °C), CF/MWCNTs multi-scale reinforcements (MSCF) were successfully prepared through a two-step method of MWPU sizing and MWCNTs ultrasonic grafting, which overcame the complex process flow, greatly shortened the preparation time and avoided damage to fibers. The successful grafting of MWCNTs was proved by the results of SEM and HRTEM. After grafting MWCNTs, the interface between the matrix and fibers was enhanced. The interlaminar shear strength (ILSS) and flexural strength of MSCF/epoxy reinforced composites were promoted to 64.54 MPa and 981.95 MPa, which was prominently increased by 52.84% and 32.32%, respectively. In addition, this process could match the current production of carbon fibers for commercialization, but further research was expected to control the grafting amount of MWCNTs and their impact on performance. [Display omitted] • Maleimide grafted waterborne polyurethane emulsion was prepared, which has good storage stability. • Furan-functionalized MWCNTs were prepared by chemical treatment. • Graft of MWCNTs onto the surface of carbon fiber was realized by a simple and continuous two-step method. • The ILSS value of MSCF/epoxy composites is increased by 52.84% compared with the unsized carbon fiber. [ABSTRACT FROM AUTHOR]

Good water quality is critical to public health and aquatic ecological security of global reservoirs. In stratified reservoirs, increasing near-term management demands foster extremely high monitoring and forecasting needs. In this study, a management assistant for stratified reservoirs (MASR) was developed, including a wave-driven monitoring platform and interpretation platform for multiple reservoir water quality variables. The wave-driven platform can adapt to the characteristics of water level changes and transmit the monitoring data through a mobile network to the reservoir manager, which are processed by the interpretation platform in real time for near-term management. After several months of application, MASR monitored 1237 groups of valid profile water quality data with an acceptable error, which showed a strong capacity for capturing the water quality dynamics in a stratified reservoir. The effective identification of thermal stratification structures and anoxic zones can help managers to design withdrawal schemes for reservoirs. Moreover, the prediction of algae state based on the back propagation (BP) neural network provided the basis for making operation plans to proactively control algae blooms. Our study provides an economical and convenient solution for stratified reservoirs to address near-term management issues. [Display omitted] • MASR was developed to observe multiple water quality variables of stratified reservoirs profile. • MASR could identify thermal stratification and anoxic zone, and predict the algae blooms in real time. • Near-term withdrawal schemes and operation plans can be design based on the monitoring and analysis results from MASR. [ABSTRACT FROM AUTHOR]

A facile sol–gel polymerization and impregnation route is developed to large-scale fabricate the novel mesoporous 3D interconnected NiCo-NiCoO 2 /carbon xerogel (CX) hybrids with a homogeneous carbon coating layer on the surface of NiCo and NiCoO 2 nanoparticles, the metallic NiCo nanoparticles are introduced in the NiCo-NiCoO 2 /CX hybrids via a partially reducing chemical reaction at a high annealing temperature. The mesoporous 3D interconnected NiCo-NiCoO 2 /CX hybrids show significantly improved electrochemical performance of high reversible capacity, high-rate capability, and excellent cycling performance as anode electrode materials for Lithium ion batteries (LIBs). After 100 cycles, the NiCo-NiCoO 2 /CX hybrids anode can still get a reversible capacity of 861 mAh g −1 at current density of 100 mA g −1 , which is 2.8 and 1.9 times higher than that of the CX (305 mAh g −1 ) and NiCoO 2 /CX hybrid (456 mAh g −1 ), respectively. The greatly enhanced electrochemical lithium ion storage performance of the NiCo-NiCoO 2 /CX hybrids can be attributed to their unique microstructure characteristics. The elastic nature of CX matrices and carbon layer coating on the surfaces of NiCo and NiCoO 2 nanoparticles, renders the NiCo-NiCoO 2 /CX hybrids very effective in accommodating the volume strain. The highly dispersed NiCo particles display catalytic effect, greatly improve the kinetics of charge-discharge process of the composite anode as the following reaction of NiCo + 2Li 2 O ↔ NiO + CoO + 4Li + + 4e − . The introduction of metallic NiCo can effectively facilitate the decomposition of Li 2 O and the SEI during the charge-discharge process, thus greatly enhance the electrochemical performance. Secondly, the presence of NiCo in the NiCo-NiCoO 2 /CX composite anode can greatly improve the electron conductivity, thus charge transfer kinetics of the composite anode for LIBs. EIS result can well confirm this result. While the homogeneous distribution of NiCoO 2 with high theoretical capacity in the porous CX matrices, effectively reduces the active sites of the CX matrices, resulting in higher reversible capacity of the NiCo-NiCoO 2 /CX hybrids. [ABSTRACT FROM AUTHOR]

• An integrated framework for predicting the aquatic ecological impacts of water replenishment in lakes was developed. • Reasonable spatiotemporal coverage can reduce the uncertainty when the EFDC output was transmitted to the RF model as the input condition. • Effective areas for phytoplankton diversity restoration are related to water quality and quantity, water replenishment routing and internal hydrological connectivity. • Water replenishment in spring is crucial for alleviating the decrease in phytoplankton biodiversity in estival Baiyangdian Lake. An extensive artificial water diversion project aimed at alleviating the shortage of ecological water in lakes can change the original hydrological and physicochemical states and further affect the structure and distribution of phytoplankton communities. Therefore, it is important to fully evaluate the ecological restoration effect of the water diversion project on the water-receiving area before implementing water replenishment. For this purpose, we developed an integrated model framework based on the Environmental Fluid Dynamics Code (EFDC) and Random Forest (RF). We adopted a probability distribution method to address the uncertainty during model coupling. This framework was implemented to simulate and predict the evolution of phytoplankton diversity in Baiyangdian Lake (BL) in China. To solve the problem that the phytoplankton biodiversity in BL decreased especially in summer due to human activity, the Yellow River into BL, the south-to-north water diversion project, and joint replenishment of upstream reservoirs have been implemented in recent years. Our framework was used to analyze the biodiversity restoration effects of multi-source water replenishment through different routings. The results show that spatiotemporal coverage should be considered to reduce uncertainty during model coupling. Water replenishment has a positive impact on the biodiversity of BL; however, there are effective areas for phytoplankton diversity restoration, which are related to water quality and quantity, water replenishment routing and internal hydrological connectivity. The Xiaobai River has the most significant water ecological restoration potential among the routings, compared with that of the Baigou and Fu Rivers. Appropriate water replenishment in spring will play a vital role in alleviating the decrease in phytoplankton biodiversity in summer owing to flood control. [ABSTRACT FROM AUTHOR]

Abstract: Transition metal sulfides are regarded as another type of high-performance anode materials following the transition metal oxides for lithium ion batteries. However, the lithium storage mechanisms of these sulfides are complicated. This work is intended to evaluate the electrochemical performances of molybdenum disulfide (MoS2) and find out its lithium storage mechanism at different lithium insertion stages. It is found that although the MoS2 shows excellent cycling stability in different voltage ranges, its structural transition is irreversible in the initial cycling. In contrast to the traditional beliefs, metallic Mo is found inert and Li2S/S is the redox couple in a deeply discharged MoS2/Li cell (0.01V vs. Li/Li+). The metallic Mo nanoparticles are believed to be responsible for the enhanced cycling stability of the cell and act as the electronically conducting phase in the capacitive energy storage on the interfaces or grain boundaries of Mo/Li2S x nanocomposite. In addition, the Mo/Li2S nanocomposite can be used as a cathode material for lithium–sulfur batteries. [Copyright &y& Elsevier]

Abstract: Titanium dioxides (TiO2) nanoparticles with one-dimensional (1D) geometry, nanorods and nanostripes, were used as photocatalysts to photodegrade Rhodamine B (RhB) under ultraviolet (UV) and visible irradiation. The nanorods catalyst exhibited very interesting photocatalytic properties: under the UV irradiation its catalytic activity was slightly below that of the well-known TiO2 catalyst P25, while under visible light it exhibited a better activity than P25. This fact indicates that the nanorods have a superior ability to utilize less energetic but more abundant visible light. Moreover, the 1D TiO2 nanoparticles can be readily separated from aqueous suspensions by sedimentation after the reaction. With these advantages the 1D TiO2 catalysts have a great potential for environmental applications. Various analytical techniques were employed to characterize TiO2 catalysts and monitor the photocatalytic reaction. It was found that the catalytic performance of the catalysts is greatly dependent on their structures: The superior activity of P25 (consists of anatase and rutile nanocrystals) under UV light results probably from the interfacial interaction between anatase and rutile nanocrystals in this solid, which do not exist in the nanorods (only anatase). The titanate nanostripes (titanate) can absorb UV photons with shorter wavelength only. [Copyright &y& Elsevier]

Abstract: A novel sol–gel method based on V2O5·nH2O hydro-gel was developed to synthesize nanocrystalline Li3V2(PO4)3/carbon composite material. In this route, V2O5·nH2O hydro-gel, NH4H2PO4, Li2CO3 and high-surface-area carbon were used as starting materials to prepare precursor, and the Li3V2(PO4)3/carbon was obtained by sintering precursor at 750°C for 4h in flowing argon. The sol–gel synthesis ensures homogeneity of the precursors and improved reactivity. The sample was characterized by XRD, SEM and TEM. X-ray diffraction results show Li3V2(PO4)3 sample is monoclinic structure with the space group of P21/n. The TEM image indicates that the Li3V2(PO4)3 particles modified by conductive carbon are about 70nm in diameter. The Li3V2(PO4)3/carbon system showed that the discharge capacities in the first and 50th cycle are about 155.3 and 143.6mAh/g, respectively, in the range of 3.0–4.8V. The sol–gel method is fit for the preparation of Li3V2(PO4)3/carbon composite material which may offer some favorable properties for commercial application. [Copyright &y& Elsevier]

MmNi3.6Co0.7Al0.3Mn0.4 alloys containing carbon nanotubes were prepared by an arc-melting method. It was confirmed by SEM images that a few carbon nanotubes coated or uncoated with AB5 alloy stuck out of the surface of the alloy. The effects of the addition of carbon nanotubes on the structure and the electrochemical characteristics of AB5-type alloy were investigated by XRD and electrochemical measurements. Discharge plateau curves of sigmoid shape were clearly observed for AB5-CNT electrodes during the initial activation, which was different from the original AB5 electrode. In addition, the results indicate that, with the addition of carbon nanotubes, the unit cell volume decreased resulting in a decrease of the stability of the metal hydride and an increase in the discharge plateau potential. The discharge capacity for the alloys decreased with decreasing stability of the metal hydride due to the decrease of maximum amount of the absorbed hydrogen, but the high-rate dischargeability was improved due to the increase in the rate of hydrogen diffusion in the alloys. The capacity retaining ability of the alloys did not remarkably decrease with the addition of carbon nanotubes. [Copyright &y& Elsevier]

In this paper, a simple and efficient regeneration technology of low-temperature pickling regeneration process is proposed for Cu(II)-adsorbed activated carbon fiber felts (ACFFs). The regeneration process mainly uses the strong oxidation of acidic regenerant above boiling point to regenerate ACFFs in a confined space. With no demand for high temperature and high pressure, the regeneration process achieves a high efficiency regeneration and a remarkable enhancement of Cu(II) adsorptivity simultaneously for Cu(II)-adsorbed ACFFs. After parameter optimization, the pickling temperature of 383 K, pickling time of 3 h and HNO 3 concentration of 150 g/L are adopted as optimum process parameters for the reutilization of ACFFs. The regeneration rates of ACFFs in five cycles are maintained at 424.08%–829.59%. Analytical results show that the enhancement of Cu(II) adsorptivity is mainly caused by the remarkable enhancement of specific surface area (increased by 106.08%), micropore volume (increased by 102.17%) and more abundant surface chemical structure (particularly carboxyl and nitro group) after treated by the regeneration process. • Low-temperature-pickling regeneration process is first reported. • During regeneration, specific surface area and micropore volume are increased by 106.08%, 102.17% separately. • 729.59% anti-growth of ACFFs' Cu(II) adsorptivity is achieved by the novel regeneration process. [ABSTRACT FROM AUTHOR]

Rechargeable non-aqueous lithium oxygen batteries (LOBs) have attracted extensive attention as the most promising next-generation battery technologies due to their extremely high theoretical energy density. However, their practical applications are hampered by sluggish reaction kinetics and severe parasitic reactions, resulting from the insulating and insoluble discharge product-Li 2 O 2. Herein, self-standing ZnCo 2 S 4 nanosheet arrays derived from metal-organic framework (MOF) via low-temperature solvothermal sulfuration method, are fabricated as efficient cathode for LOBs. The hollow structure of ZnCo 2 S 4 nanosheet formed during sulfuration provides more catalytic sites and alleviates stress during repeated discharge/charge progress, while three-dimensional (3D) porous architecture inheriting from MOF shortens the transportation pathway of Li+ and O 2 in electrolyte. Compared with pure CoS derived from Co-MOF, more Co3+ exposes on ZnCo 2 S 4 surface due to the introduction of Zn, enhancing the catalytic activity distinctly. Benefitting from the bifunctional catalytic performance, the ZnCo 2 S 4 cathode exhibits an extremely high initial discharge capacity of 9505 mAh g−1 at 100 mA g−1. Additionally, it also achieves a smaller overpotential of 1.02 V under a cutoff capacity of 1000 mAh g−1 and a longer cycle life of 90 cycles at 100 mA g−1. This work provides new insights into designing efficient bifunctional catalyst for LOBs. Image 1 • 3D porous ZnCo 2 S 4 nanosheet arrays with hollow structure are fabricated as bifunctional catalyst for LOBs. • More surface-exposed Co3+ induced by Zn introduction augments the ORR and OER catalytic activity remarkably. • The ZnCo 2 S 4 cathode exhibits extremely high discharge capacity of 9505 mAh g-1 at 100 mA g-1. • The discharge product Li 2 O 2 displays unique morphology of large discs with interconnected nanosheets. [ABSTRACT FROM AUTHOR]

• The eddy correlation method was adopted to measure SWI oxygen fluxes in reservoirs. • Benthic DO exchange is inhibited in a stratification related anoxic condition. • Hydrodynamic drives to flux are increasingly significant as stratification weakens. • The DO concentrations coupled with hydrodynamics determine SWI oxygen fluxes. Benthic oxygen fluxes at the sediment-water interface (SWI) regulate the process and even direction of biochemical interfacial reactions; thus, they are crucial to the water quality. However, many medium- and large-sized reservoirs suffer from thermal stratification and human operations, lead to a significant impact on SWI oxygen exchanges. A 3-month-long noninvasive measurement of SWI oxygen fluxes was conducted in the Daheiting Reservoir using the eddy correlation method. Its result shows that reservoir stratification markedly affects the benthic boundary layer environment factors such as temperature, dissolved oxygen (DO) concentration, and hydrodynamics. In contrast, reservoir operations determine the benthic flow directions and its correlation to velocities in the mixed stage. A further discussion suggests that benthic temperatures mainly participate in the thermal structure rather than directly affecting the benthic fluxes. Conversely, it is DO concentrations coupled with hydrodynamics that control SWI oxygen fluxes. The flux is inhibited by DO shortage in anoxic conditions, but it is mainly controlled by hydrodynamics with redundant DO. Likewise, the hydrodynamics affects the fluxes by changing the diffusive boundary layer thickness, but this effect is also restrained by the DO field. These results indicate that a long-term and in-situ measurement of SWI oxygen fluxes in drinking reservoirs is of considerable significance to forecast water quality disasters, optimize operation plans, and ensure water security. [ABSTRACT FROM AUTHOR]

In aquatic ecosystems, phytoplankton, as key primary producers, are extremely sensitive to environmental changes. Artificial hydrological regulation, as a water resource management strategy, affects the water quality and ecological environment of the receiving water area. Particularly under multi-source replenishment conditions, the spatiotemporal nonlinear response of water quality poses a challenge to quantify the contribution of multi-source replenishment to the phytoplankton community succession in large lakes. For example, Baiyangdian Lake (BL) has implemented multi-source artificial hydrological regulation measures, including the diversion of the Yellow River into the BL (Xiaobai River), the South-to-North Water Diversion Project (Baigouyin River) and the replenishment of upstream reservoirs (Xiaoyi River, Bao River and Fu River). Physicochemical parameters and phytoplankton community data were surveyed from 2017 to 2020 in July (summer) and October (autumn). The ecological impacts of artificial hydrological regulation were investigated by quantifying the correlations between physicochemical parameters and phytoplankton communities and by quantifying the contribution of artificial hydrological regulation to key factors. The results show that under the artificial hydrological regulation, the phytoplankton community was still dominated by Chlorophyta and Cyanophyta, but the emergence of Xanthophyta and Chrysophyta indicated that the cleanliness of the water column was improved, and the biodiversity indicators showed a fluctuating upward trend, which suggested that the succession trend was favorable. Ammonia nitrogen (NH 3 -N), total phosphorus (TP), and dissolved oxygen (DO) are the key factors affecting phytoplankton community succession in BL. The replenishment sources contribution index (RSCI) was used to characterize the spatiotemporal response of the key factors, and it was found that Fu River has the highest contribution of more than 30%, followed by Xiaoyi River with a contribution of more than 25%. The spatial distribution of RSCI shows that the area with high RSCI values (>0.9) of Fu River accounts for more than 50% of the total area, the area with high RSCI values (>0.9) of Xiaoyi River accounts for more than 35%. Under the comprehensive influence of the RSCI of each replenishment source, the phytoplankton biodiversity index of BL increased from north to south. This study provides basic support for BL in realizing the optimized artificial hydrological regulation strategy and enhancing the ecological restoration benefits in the receiving water area., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Background: Childhood maltreatment contributes to an increased risk of eating disorders in adolescents. However, less is known regarding the underlying mechanism between childhood maltreatment and eating disorders' symptoms. This study tested the mediation effect of social anxiety in the association between childhood maltreatment and eating disorders' symptoms and whether this mediation was moderated by physical activity., Methods: A longitudinal study was conducted among 848 students in grades 7-8 from a middle school in Changsha, China. The students completed measurements on childhood maltreatment (Childhood Trauma Questionnaire) at the baseline and measurements on social anxiety (The Social Anxiety Scale-Adolescents), physical activity, and eating disorders' symptoms (The Eating Attitudes Test) after six months. Mediation and moderation analyses were carried out in SPSS macro-PROCESS., Results: Emotional abuse was significantly related to eating disorders'symptoms, and the association was mediated by social anxiety (indirect effect: β = 0.03, 95% CI: 0.01 to 0.05, p<0.05). Furthermore, physical activities moderated the path of emotional abuse to social anxiety (β = 0.32, 95% CI: 0.25 to 0.39, p<0.01) and social anxiety to eating disorders'symptoms (β = 0.18, 95% CI: 0.10 to 0.26, p<0.01)., Conclusion: This research emphasizes the importance of social anxiety in the relationship between childhood maltreatment and eating disorders' symptoms. Additionally, these associations are weaker for adolescents with more physical activities, addressing the importance of physical activity in the prevention and management of eating disorders' symptoms., Competing Interests: The authors report no conflicts of interest in this work., (© 2024 Li et al.)

All-solid-state lithium-sulfur batteries (ASSLSBs) using poly(ethylene oxide) (PEO) electrolytes offer significant advantages in energy density and safety. However, their development is hampered by the slow Li + conduction in solid polymer electrolytes and sluggish electrochemical conversion at the cathode-electrolyte interface. Herein, we fabricate a self-healing poly(β-amino ester) with a comb-like topological structure and multiple functional groups, synthesized through a Michael addition strategy. This material modifies the PEO-based solid-state electrolyte, creating fast Li + transport channels and improving polysulfides conversion kinetics at the electrode surface. Consequently, both modified all-solid-state lithium symmetric cells and lithium-sulfur batteries exhibit improved electrochemical performance. This work demonstrates an expanded interpenetrating macromolecular engineering approach to develop highly ion-conductive solid polymer electrolytes for ASSLSBs.

Heavy metal sediment pollution has become an increasingly serious problem associated with industrial development, so extensive studies have been conducted concerning their removal. Biochar has recently shown good potential for in-situ remediation of heavy metal-contaminated sediments. The heavy metal adsorption capacity of inexpensive biochar can be improved by loading it with metal oxides. In this study, manganese-modified biochar (MBC) was prepared by KMnO 4 -modified waste-activated sludge biochar and applied to immobilize Pb and Cd in sediments. Its effects on the sediment microbial community were also investigated. The Results showed that manganese modification of the biochar made it more conducive to the adsorption of heavy metals, owing to its higher specific surface area and graphitization structure, more active sites and oxygen-containing groups, and the presence of Mn 2 O 3 crystal structure on the surface. The maximum adsorption capacities of this material for Pb 2+ and Cd 2+ in solution were 176.9 mg/g and 44.0 mg/g, respectively. The application of MBC to the remediation of heavy metal-contaminated sediments transformed Pb and Cd in the sediments from exchangeable to residual state. The F4 content of Pb in the sediments increased from 40.52%-42.36% to 49.11%-51.14% after application of 1% MBC, and to 63.94%-64.49% after application of 5% MBC. Correspondingly, the F1 content of Pb in the sediments decreased from 29.09%-30.68% to 17.43%-17.69% after the application of 5% MBC. Furthermore, MBC efficiently enriched the microbial biodiversity and affected the microbial population structure within 60 days. The relative abundance of uncultured f Symbiobacteraceae and Fonticella communities significantly increased after incubation. The results may provide empirical support for the combination of metal oxides and biochar for the remediation of heavy metal-contaminated sediments., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Background: Cardiovascular diseases (CVDs) are the leading age-related disorders worldwide, with their prevalence increasing annually. Cathepsins are protein-degrading enzymes essential for processes such as intracellular protein breakdown, apoptosis, and immune responses. Recent studies suggest a potential link between cathepsins and CVDs, yet the exact causal relationship remains to be elucidated. To address this, we propose using Mendelian randomization (MR) to explore the causal relationships between cathepsins and CVDs. Methods: We obtained single nucleotide polymorphism (SNP) data for cathepsins from the INTERVAL study, a publicly accessible genome-wide association study (GWAS) dataset. Outcome SNP data were sourced from seven distinct GWAS datasets, ensuring a comprehensive analysis across multiple cardiovascular outcomes. For MR analysis, we primarily employed the inverse variance weighted (IVW) method, known for its efficiency when all SNPs are valid instruments. This was supplemented by the weighted median and MR-Egger methods to provide robustness against potential violations of MR assumptions, such as pleiotropy. The IVW method offers precision and efficiency, the weighted median method adds robustness against invalid instruments, and the MR-Egger method helps identify and correct for pleiotropic biases. Cochran's Q test was utilized to assess heterogeneity, and sensitivity analyses were conducted using MR-PRESSO and the leave-one-out approach. Results: The strength of the associations between exposure and outcome was measured using odds ratios (ORs), and results were presented with 95% confidence intervals (CIs). The cathepsin E increases the risk of myocardial infarction (MI) (OR = 1.053%, 95% CI: 1.007-1.101, p = 0.024) and ischemic stroke (IS) (OR = 1.06%, 95% CI: 1.019-1.103, p = 0.004). Conversely, cathepsin L2 decreases the risk of chronic heart failure (CHF) (OR = 0.922%, 95% CI: 0.859-0.99, p = 0.025) and atrial fibrillation (AF) (OR = 0.956%, 95% CI: 0.918-0.996, p = 0.033). Cathepsin O was associated with an increased risk of IS (OR = 1.054%, 95% CI: 1.008-1.102, p = 0.021) and AF (OR = 1.058%, 95% CI: 1.02-1.098, p = 0.002). Conclusion: Our MR analysis reveals that cathepsin E is a risk factor for MI and IS, cathepsin L2 offers protective effects against CHF and AF, and cathepsin O increases the risk for IS and AF., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Li, Zhou, Xu, Gao, Lou, Chen, Zhang, Fang, Tan and Huang.)

Hypoxia in stratified waters greatly threatens aquatic ecology and societal development owing to enhanced nutrient discharge and increasing global temperature. Current research predominantly alleviates hypoxia by reducing dissolved oxygen (DO) consumption or conducting hypolimnetic oxygenation, yet their implementation has encountered bottlenecks. Therefore, this study explores the potential of increasing the inherent DO supplies in stratified reservoirs to mitigate hypoxia. High-frequency in situ observations and massive modeling experiments are integrated to discern the DO supply mode and the dominant driver of DO evolution. Results indicate that periodic thermodynamic conditions determine the DO supply relationships between oxygen sources (inflow carriage, reaeration, and photosynthesis) for different water layers. Thermal stratification causes the hypolimnion to rely mostly on the inflow for DO supply, leading to a fragile budget prone to hypoxia. However, episodic hydrodynamic events (turnover, wind stir, density current, and flood) can promote DO supply and inhibit hypoxia. Temperature and DO regimes are primarily driven by outflow conditions, followed by inflow and meteorology conditions. Furthermore, hypolimnetic hypoxia can be regulated by altering inflow volume, outflow volume, and outlet elevation. These findings highlight the importance of longitudinal solute exchange in DO evolution in stratified reservoirs, providing a basis for alleviating hypoxia through cascade reservoir operations., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Objective: To explore the efficacy and safety of clonidine adhesive patch in Tourette syndrome (TS) patients with comorbid attentiondeficit/hyperactivity disorder (ADHD)., Methods: This study was conducted on a sample of children and adolescents with TS who had comorbid ADHD between May 2012 and March 2015. The patients were diagnosed according to Diagnostic and Statistical Manual of Mental Disorders Fourth Edition, and were randomly assigned to four different dose groups: 1.0 mg/week, 1.5 mg/week, 2.0 mg/week and placebo group, and the symptom was evaluated by Swanson, Nolan, and Pelham Rating Scale, Version IV (SNAP-IV) and Yale Global Tic Severity Scale scales every 2 weeks. The primary outcome was tic disorders (TD) effective rate at week 8., Results: One hundred and twenty-seven TS patients with comorbid ADHD in 2.0 mg/week (n=35), 1.5 mg/week (n=27), 1.0 mg/week (n=36) and placebo groups (n=29) were included in this subgroup analysis. The TD effective rate of the 2.0 mg, 1.5 mg, and 1.0 mg groups at week 8 were significantly better than that in placebo group (85.7%, 81.5%, and 86.1% vs. 20.7%, all p<0.0001). All groups demonstrated significant improvements in SNAP-IV total scale scores compared to baseline (p=0.0004), with treatment groups showing only a trend for better performance compared to placebo group at week 8, without statistical differences (22.1±15.41, 21.3±11.96, and 21.2±12.48 vs. 26.0±13.37, p=0.3385). A total of 9 adverse reactions occurred, all recovered spontaneously without additional medication., Conclusion: Clonidine adhesive patch could safely and effectively reduce the tic symptoms of TS patients with comorbid ADHD, and might be potentially helpful in the ADHD symptoms control.

Objective: CHARGE syndrome is a rare autosomal dominant (AD) multi-system disorder with a broad and variable clinical manifestation and occurs in approximately 1/10,000 newborns in the world. Mutations in the CHD7 gene are the genetic cause of over 90% of patients with typical CHARGE syndrome. The present study reported a novel variant in the CHD7 gene in a Chinese family with an abnormal fetus., Methods: Routine prenatal ultrasound screening showed fetal heart abnormality and left foot varus. Chromosomal microarray analysis (CMA) and fetus-parent whole-exome sequencing (trio-WES) were performed to determine the genetic cause of the fetus. The candidate variant was further verified using Sanger sequencing., Results: CMA analysis revealed normal results. However, WES analysis identified a de novo heterozygous variant of c.2919&#95;2922del (NM&#95;017780.4) on exon 11 of CHD7 gene, resulting in a premature truncation of the CHD7 protein (p.Gly975*). The variant was classified as Pathogenic (PVS1 + PS2&#95;Moderate + PM2&#95;Supporting) based on the ACMG guidelines. Combined with the clinical phenotype of fetal heart abnormalities, it was confirmed CHARGE syndrome., Conclusion: We identified a novel heterozygous variant c.2919&#95;2922del in CHD7 of a Chinese fetus with CHARGE syndrome, enriching the genotype-phenotype spectrum of CHD7. These results suggest that genetic testing could help facilitate prenatal diagnosis of CHARGE syndrome, thus promoting the appropriate genetic counseling., (© 2023. The Author(s) under exclusive licence to The Genetics Society of Korea.)

Improving the sulfur content in the cathode is essential for achieving high-energy-density all-solid-state lithium-sulfur batteries (ASSLSBs). However, the complex multiinterfaces, akin to the short wooden planks that consist of the cask, severely limit the performance of ASSLSBs with high sulfur content. Since singular approaches fail to optimize these interfaces simultaneously, we propose a synergistic approach using a dual-doped sulfide solid electrolyte (Y 2 S 3 and LiI) and an SbSn alloy sulfur host in this work. The incorporation of Y 2 S 3 in the solid electrolyte serves to improve the electrolyte-electrolyte interfaces and enhance the ionic conductivity, while the inclusion of LiI helps stabilize the electrolyte-anode interface and suppress dendrite formation. Meanwhile, the SbSn alloy sulfur host facilitates the transfer of Li + at the electrolyte-cathode interfaces. Consequently, the solid-solid interfaces are significantly improved, leading to impressive specific capacities in ASSLSBs with high sulfur content (>44% in the cathode composite) at room temperature (1163.5 mAh g -1 ) and at 60 °C (1408.7 mAh g -1 ) during the 50th cycle at 0.05C. This work presents a promising strategy for achieving practical high-performance ASSLSBs.

Sediment respiration, the relation between dissolved oxygen (DO) attribution and carbon dioxide (CO 2 ) emission, is an important index of the aquatic ecosystem and a key concern in the evaluation of reservoir cleanliness performance. To understand the sediment respiration dynamics regulated by the thermal stratification that is common in deep-water reservoirs, this study conducted in-situ measurements of thermal structures and benthic environments in the Daheiting Reservoir for 16 months. Then, the variations of DO and CO 2 fluxes at the sediment-water interface (SWI) were obtained based on the aquatic eddy correlation method and the newly proposed virtual incubator method, respectively. The results show that the SWI fluxes dynamics can be decomposed into tendency variations dominated by thermal stratification and impulse variations induced by extreme events. The annual average SWI DO and CO 2 fluxes of 3.80-6.62 and 1.92-3.15 mmol m -2 ·d -1 are estimated in the study site through the respiration dynamics, respectively, which CO 2 flux is at a moderate level among the nearly 50 lakes and reservoirs worldwide but accounts for less than 15% of the total CO 2 emission of this reservoir. Moreover, the sediment respiration quotient in stratified reservoirs is lower than in other aquatic environments, suggesting that the permanently flooded area is a weak net carbon source, while most carbon emissions from stratified reservoirs are carbon displacement or net carbon generated within the water. Sediment net carbon emissions correspond to human benefits such as flood control, power generation, and fisheries, whereas water net carbon emissions are usually not beneficial. Therefore, reducing net carbon emissions generated in the water may become an important way to achieve low-carbon operation of deep-water reservoirs., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Background: Childhood maltreatment is associated with internet addiction, but most evidence is from retrospective studies., Aims: We aimed to investigate the relationship between childhood maltreatment and internet addiction through a prospective cohort design., Method: In a prospective cohort study, self-reported data on childhood maltreatment (Childhood Trauma Questionnaire - Short Form) at baseline, and internet addiction (Revised Chinese Internet Addiction Scale) at baseline and 6-month follow-up, were collected online from 756 Chinese junior middle school students aged 11-15 years and residing in Changsha, Hunan Province. Demographic data and covariates such as depression, anxiety, stress (Depression, Anxiety, and Stress Scale 21) and insomnia (Athens Insomnia Scale) were also surveyed at baseline. Logistic regression analysis measured the association between childhood maltreatment and internet addiction, and gender-related differences., Results: Childhood maltreatment was prevalent in Chinese junior middle school students (37.83%), and the incidence rate of internet addiction was 9.26% at the 6-month follow-up. Emotional abuse was a significant risk factor for internet addiction (adjusted odds ratio 2.618, 95% CI 1.194-5.738; P = 0.016) in both males and females., Conclusions: This study suggests a high prevalence of childhood maltreatment in Chinese junior middle school students, and that emotional abuse plays a significant role in internet addiction. More attention should be paid to parenting style and adolescents' mental health.

Cycling stability and safety are two of the main challenges facing lithium metal batteries with metallic lithium as anodes. Quasi-solid-state lithium metal batteries based on gel polymer electrolytes are one of the important development directions for lithium metal batteries addressing those challenges. Herein, we prepare lithiated phosphoryl cellulose nanocrystals (PCNC-Li) as a modification material for poly(vinylidene fluoride) (PVDF) gel polymer electrolyte to improve cycling stability and safety of quasi-solid-state lithium metal batteries. The synthesized PCNC-Li tends to form a uniform network structure on the surface of the PVDF membrane, in which the phosphoryl groups grafted regularly on celluloses can regulate the transport of lithium ions. As a result, a more uniform ion flux and more stable lithium anode interface support an obviously improved cycling stability for lithium metal batteries. Moreover, the introduction of the PCNC-Li coating layer makes the modified PVDF membranes have a better thermal stability and an enhanced mechanical strength, which is beneficial for improvement of safety of lithium metal batteries. This work provides a new alternative to fabricating a better composite gel polymer electrolyte for lithium metal batteries.

Introduction: Internet addiction (IA) is common among adolescents and may have severe consequences. This study aimed to investigate the prevalence and factors associated with IA among middle school students of Hunan Province, China. Relevance between IA and childhood trauma was also explored., Methods: One thousand six hundred ten students were enrolled in this cross-sectional study. Data collected included demographics; internet addiction (revised-Chen internet addiction scale); childhood trauma (CTQ-SF); depression, anxiety, and stress symptoms (DASS-21); suicidal behaviors, as well as non-suicidal self-injury (NSSI). Cramer's V analysis, univariable logistic regression and multivariable logistic regression were used for associations and identifying independent relevance of IA, respectively., Results: The prevalence of IA was 12.8%. Cramer's V analysis showed that IA was associated with emotional abuse, emotional and physical neglect, NSSI, suicidal behaviors, stress, anxiety and depressive symptoms, physical disorder history. Regression analysis showed that IA was independently associated with emotional neglect (OR = 3.062, 95% CI: 2.083, 4.501, p  < 0.001); physical neglect (OR = 2.328; 95% CI: 1.590, 3.409, p  < 0.001); depressive symptoms (OR = 2.218, 95% CI: 1.467, 3.353, p  < 0.001) nationality (OR = 1.888, 95% CI: 1.034, 3.447, p  = 0.006) and age (OR = 1.253, 95% CI: 1.066, 1.471, p  = 0.006)., Discussion: IA is common among middle school students. Attention should be paid to students with childhood trauma since they have a higher risk for IA, which may increase the risk for suicidal behaviors., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher., (Copyright © 2023 Fan, Twayigira, Song, Luo, Huang, Gao and Shen.)

Background: Glioma patients often experience unfavorable outcomes and elevated mortality rates. Our study established a prognostic signature utilizing cuproptosis-associated long non-coding RNAs (CRLs) and identified novel prognostic biomarkers and therapeutic targets for glioma. Methods: The expression profiles and related data of glioma patients were obtained from The Cancer Genome Atlas, an accessible online database. We then constructed a prognostic signature using CRLs and evaluated the prognosis of glioma patients by means of Kaplan-Meier survival curves and receiver operating characteristic curves. A nomogram based on clinical features was employed to predict the individual survival probability of glioma patients. Functional enrichment analysis was conducted to identify crucial CRL-related enriched biological pathways. The role of LEF1-AS1 in glioma was validated in two glioma cell lines (T98 and U251). Results: We developed and validated a prognostic model for glioma with 9 CRLs. Patients with low-risk had a considerably longer overall survival (OS). The prognostic CRL signature may serve independently as an indicator of prognosis for glioma patients. In addition, functional enrichment analysis revealed significant enrichment of multiple immunological pathways. Notable differences were observed between the two risk groups in terms of immune cell infiltration, function, and immune checkpoints. We further identified four drugs based on their different IC50 values from the two risk groups. Subsequently, we discovered two molecular subtypes of glioma (cluster one and cluster two), with the cluster one subtype exhibiting a remarkably longer OS compared to the cluster two subtype. Finally, we observed that inhibition of LEF1-AS1 curbed the proliferation, migration, and invasion of glioma cells. Conclusion: The CRL signatures were confirmed as a reliable prognostic and therapy response indicator for glioma patients. Inhibition of LEF1-AS1 effectively suppressed the growth, migration, and invasion of gliomas; therefore, LEF1-AS1 presents itself as a promising prognostic biomarker and potential therapeutic target for glioma., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Chen, Xu, Gao, Zhu, Liu and Yan.)

Background: Frontotemporal cortex dysfunction has been found to be associated with cognitive impairment in patients with schizophrenia (SCZ). In patients with adolescent-onset SCZ, a more serious type of SCZ with poorer functional outcome, cognitive impairment appeared to occur at an early stage of the disease. However, the characteristics of frontotemporal cortex involvement in adolescent patients with cognitive impairment are still unclear. In the present study, we aimed to illustrate the frontotemporal hemodynamic response during a cognitive task in adolescents with first-episode SCZ., Methods: Adolescents with first-episode SCZ who were aged 12-17 and demographically matched healthy controls (HCs) were recruited. We used a 48-channel functional near-infrared spectroscopy (fNIRS) system to record the concentration of oxygenated hemoglobin (oxy-Hb) in the participants' frontotemporal area during a verbal fluency task (VFT) and analyzed its correlation with clinical characteristics., Results: Data from 36 adolescents with SCZ and 38 HCs were included in the analyses. Significant differences were found between patients with SCZ and HCs in 24 channels, mainly covering the dorsolateral prefrontal cortex, superior and middle temporal gyrus and frontopolar area. Adolescents with SCZ showed no increase of oxy-Hb concentration in most channels, while the VFT performance was comparable between the two groups. In SCZ, the intensity of activation was not associated with the severity of symptoms. Finally, receiver operating characteristic analysis indicated that the changes in oxy-Hb concentration could help distinguish the two groups., Conclusion: Adolescents with first-episode SCZ showed atypical cortical activity in the frontotemporal area during the VFT, and fNIRS features might be more sensitive indicators in cognitive assessment, indicating that the characteristic hemodynamic response pattern might be potential imaging biomarkers for this population., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Zhang, Jin, He, Wu, Cui, Gao, Huang and Luo.)

Background: Cholangiocarcinoma (CHOL) is the most prevalent type of malignancy and the second most common form of primary liver cancer, resulting in high rates of morbidity and mortality. Necroptosis is a type of regulated cell death that appears to be involved in the regulation of several aspects of cancer biology, including tumorigenesis, metastasis, and cancer immunity. This study aimed to construct a necroptosis-related gene (NRG) signature to investigate the prognosis of CHOL patients using an integrated bioinformatics analysis., Methods: CHOL patient data were acquired from the Gene Expression Omnibus (GEO) (GSE89748, GSE107943) and The Cancer Genome Atlas (TCGA) databases, with NRGs data from the necroptosis pathway in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Univariate and multivariate regression analyses were performed to establish the NRG signatures. Kaplan-Meier (KM) curves were used to evaluate the prognosis of patients with CHOL. Functional enrichment analysis was performed to identify key NRG-associated biological signaling pathways. We also applied integrative multi-omics analysis to the high- and low-risk score groups. Spearman's rank correlation was used to clarify the relationship between the NRG signature and immune infiltration., Results: 65 differentially expressed (DE) NRGs were screened, five of which were selected to establish the prognostic signature of NRG S based on multivariate Cox regression analysis. We observed that low-risk patients survived significantly longer than high-risk patients. We found that patients with high-risk scores experienced higher immune cell infiltration, drug resistance, and more somatic mutations than patients with low-risk scores. We further found that sensitivities to GW843682X, mitomycin C, rapamycin, and S-trityl-L-cysteine were significantly higher in the low-risk group than in the high-risk group. Finally, we validated the expression of five NRGs in CHOL tissues using the TCGA database, HPA database and our clinical data., Conclusion: These findings demonstrate that the five-NRG prognostic signature for CHOL patients is reasonably accurate and valid, and it may prove to be of considerable value for the treatment and prognosis of CHOL patients in the future., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Xu, Gao, Xing and Guo.)

Objectives: Cyberbullying is quite common in adolescents and college students, and it influences mental health in many aspects. The purpose of this study was to investigate the prevalence of cyberbullying in Chinese college students and to look for related factors., Methods: Eight thousand and ninety-eight college students aged 17-26 were enrolled in this cross-sectional study. We collected information of their sociodemographic data, depression (evaluated by Self-Rating Depression Scale), anxiety (evaluated by Self-Rating Anxiety Scale), lifetime suicidal behaviors (including suicidal ideation, suicidal plans, and suicide attempts), and experiences of cyberbullying for the past 12 months by online questionnaires., Results: The prevalence of cyberbullying for the past 12 months was 7.82% (633/8,098) among college students. Binary logistic regression analysis showed that sex (odds ratio, OR = 0.522, 95%CI = 0.433-0.629, p < 0.001), suicide attempts (OR = 2.164, 95%CI = 1.589-2.948, p < 0.001), depression (OR = 2.372, 95%CI = 1.602-3.512, p < 0.001), and anxiety (OR = 1.911, 95%CI = 1.305-2.800, p = 0.001) were independently associated with cyberbullying., Conclusion: Cyberbullying is very common among college students in Hunan Province, China. Besides, being male, suicide attempts, depression and anxiety were independently associated with cyberbullying, which highlights the importance of paying attention to cyberbullying and addressing anxiety, depression, and suicidal behaviors among college students to better improve their mental health and prevent suicide., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Jin, Zhang, Twayigira, Gao, Xu, Huang, Luo and Shen.)

Escherichia coli cysteine desulfurase (CD), IscS, modifies basal metabolism by transferring sulphur (S) from L-cysteine to numerous cellular pathways, whereas NFS1, a human CD, is active only in the formation of the [Acp] 2 :[ISD11] 2 :[NFS1] 2 complex. Despite the accumulation of red-coloured IscS in E. coli cells as a result of the deficiency of accessible iron, as revealed in our previous studies, the mechanism of the potential enzymatic reaction remains unclear. In this study, the N-terminus of IscS was fused with the C-terminus of NFS1, which was reported to be almost fully active as IscS and exhibits a pyridoxal 5'-phosphate (PLP) absorption peak at 395 nm. Moreover, SUMO-EH-IscS exhibited significant growth recovery and NADH-dehydrogenase I activity in the iscS mutant cells. Furthermore, through in vitro and in vivo experiments combined with high-performance liquid chromatography and ultra-performance liquid chromatography-tandem mass spectrometry, it was shown that the new absorption peaks of the IscS H104Q, IscS Q183E, IscS K206A, and IscS K206A&C328S variants at 340 and 350 nm may correspond to the enzyme reaction intermediates, Cys-ketimine and Cys-aldimine, respectively. However, after mutation of the conserved active-site residues, additional absorption peaks at 420 and 430 nm were associated with PLP migration in the active-site pocket. Additionally, the corresponding absorption peaks of Cys-quinonoid, Ala-ketimine, and Ala-aldimine intermediates in IscS were 510, 325, and 345 nm, respectively, as determined by site-directed mutagenesis and substrate/product-binding analyses during the CD reaction process. Notably, red IscS formed in vitro by incubating IscS variants (Q183E and K206A) with excess L-alanine and sulphide under aerobic conditions produced an absorption peak similar to the wild-type IscS, at 510 nm. Interestingly, site-directed mutation of IscS with hydrogen bonds to PLP at Asp180 and Gln183 resulted in a loss of enzymatic activity followed by an absorption peak consistent with NFS1 (420 nm). Furthermore, mutations at Asp180 or Lys206 inhibited the reaction of IscS in vitro with L-cysteine (substrate) and L-alanine (product). These results suggest that the conserved active site residues (His104, Asp180, and Gln183) and their hydrogen bond with PLP in the N-terminus of IscS play a key role in determining whether the L-cysteine substrate can enter the active-site pocket and regulate the enzymatic reaction process. Therefore, our findings provide a framework for evaluating the roles of conserved active-site residues, motifs, and domains in CDs., Competing Interests: Authors YP and XXi were employed by Hunan Animal Pharmaceutical Company, Hunan Agricultural Group Company, Hunan Agricultural Development & Investment Group Company, Wangcheng Economic and Technological Development Zone. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Pang, Wang, Gao, Jiang, Zhu, Liang, Liang, Wu, Xu, Ren, Xie, Wang, Sun, Xiong, Lyu, Li and Tan.)

Objectives: Shelter hospital was an alternative way to provide large-scale medical isolation and treatment for people with mild coronavirus disease 2019 (COVID-19). Due to various reasons, patients admitted to the large shelter hospital was reported high level of psychological distress, so did the healthcare workers. This study aims to introduce a comprehensive and multifaceted psychosocial crisis intervention model., Methods: The psychosocial crisis intervention model was provided to 200 patients and 240 healthcare workers in Wuhan Wuchang shelter hospital. Patient volunteers and organized peer support, client-centered culturally sensitive supportive care, timely delivery of scientific information about COVID-19 and its complications, mental health knowledge acquisition of non-psychiatric healthcare workers, group activities, counseling and education, virtualization of psychological intervention, consultation and liaison were exhibited respectively in the model. Pre-service survey was done in 38 patients and 49 healthcare workers using the Generalized Anxiety Disorder 7-item (GAD-7) scale, the Patient Health Questionnaire 2-item (PHQ-2) scale, and the Primary Care PTSD screen for the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (PC-PTSD-5). Forty-eight healthcare workers gave feedback after the intervention., Results: The psychosocial crisis intervention model was successfully implemented by 10 mental health professionals and was well-accepted by both patients and healthcare workers in the shelter hospital. In pre-service survey, 15.8% of 38 patients were with anxiety, 55.3% were with stress, and 15.8% were with depression; 16.3% of 49 healthcare workers were with anxiety, 26.5% were with stress, and 22.4% were with depression. In post-service survey, 62.5% of 48 healthcare workers thought it was very practical, 37.5% thought more practical; 37.5% of them thought it was very helpful to relief anxiety and insomnia, and 27.1% thought much helpful; 37.5% of them thought it was very helpful to recognize patients with anxiety and insomnia, and 29.2% thought much helpful; 35.4% of them thought it was very helpful to deal with patients' anxiety and insomnia, and 37.5% thought much helpful., Conclusions: Psychological crisis intervention is feasible, acceptable, and associated with positive outcomes. Future tastings of this model in larger population and different settings are warranted.

Background: The GAP Activity Towards Rags 1 (GATOR1) complex, which includes DEPDC5, NPRL2, and NPRL3, plays a key role in epilepsy. It has been reported that focal epilepsy is associated with mutations in the NPRL3 gene in some cases. We report two rare mutations in the NPRL3 gene in two unrelated Chinese families with focal epilepsy in this study. Methods: The proband and her brother in family E1 first experienced seizures at 1.5 and 6 years of age, respectively. Despite resection of epileptogenic foci, she still suffered recurrent seizures. The first seizure of a 20-year-old male proband in family E2 occurred when he was 2 years old. To identify pathogenic variants in these families, whole-exome sequencing (WES) was performed on genomic DNA from peripheral blood. Results: In family E1, the trio-WES analysis of the proband and her brother without apparent structural brain abnormalities identified a heterozygous variant in the NPRL3 gene (c.954C>A, p.Y318*, NM&#95;001077350.3). In family E2, the proband carried a heterozygous NPRL3 mutation (c.1545-1G>C, NM&#95;001077350.3). Surprisingly, the mothers of the two probands each carried the variants, but neither had an attack. Bioinformatics analysis predicted that the mutation (c.954C>A) was in the highly conserved amino acid residues of NPRL3, which affected the α-helix of NPRL3 protein, leading to a truncated protein. The splice variant (c.1545-1G>C) resulted in the loss of the last exon of the NPRL3 gene. Conclusion: The results of this study provide a foundation for diagnosing NPRL3 -related epilepsy by enriching their genotypes and phenotypes and help us identify the genetic etiologies of epilepsy in these two families., Competing Interests: XG, ZD, SX, WJ, and QY were employed by Yinfeng Gene Technology Co, Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Hu, Gao, Chen, Kan, Du, Xin, Ji, Yu and Cao.)

Efficient inverted (p-i-n) type CsPbI 3 perovskite solar cells (PSCs) have revealed promising applications due to their excellent thermal and photostability. Regulating the nucleation and crystallization of perovskite film is an important route to improving the performance of CsPbI 3 PSCs. Herein, we explored cesium acetate (CsAc) as additive to manipulate the crystallization process of CsPbI 3 perovskite films. By involving in the intermediate phase DMA 1- x Cs x PbI 3- y Ac y of perovskite, the pseudo-halide acetate (Ac - ) can retard the ion exchange reaction between DMA + and Cs + , leading to a perovskite with dense morphology, low defect density, and a long carrier lifetime. As a result, the optimal CsPbI 3 PSCs yielded a high power conversion efficiency of 18.3%. Moreover, the encapsulated devices showed excellent operational stability and the devices retained their initial performance following 500 h of operation at the maximum power point under one-sun illumination in ambient conditions., (© 2022 IOP Publishing Ltd.)

Schizophrenia patients often suffer from deficit in theory of mind (TOM). Prior neuroimaging studies revealed neuroimaging correlates of TOM deficit in adults with schizophrenia, neuroimaging correlates of TOM in adolescents is less well established. This study aimed to investigate gray matter volume (GMV) abnormalities and TOM deficits in schizophrenic adolescents, and examine the relationship between them. Twenty adolescent schizophrenic patients and 25 age, sex-matched healthy controls underwent T1-weighted magnetic resonance imaging (MRI) scans, and were examined for TOM based on the Reading the Mind in the Eyes test (RMET). Univariate voxel-based morphometry (VBM) and multivariate source-based morphometry (SBM) were employed to examine alterations of two GMV phenotypes in schizophrenic adolescents: voxel-wise GMV and covarying structural brain patterns (SBPs). Compared with controls, our results revealed a significant deficit in RMET performance of the patients, Voxel-wise VBM analysis revealed that patients exhibited decreased GMV in bilateral insula, orbitofrontal cortex, and right rolandic operculum, and GMV of these brain regions were positively correlated with RMET performance. Multivariate SBM analysis identified a significantly different between-group SBP comprising of bilateral insula and inferior frontal cortex, bilateral superior temporal cortex, and bilateral lateral parietal cortex and right rolandic operculum. The loading scores of this SBP was positively correlated with RMET performance. This study revealed impairment of TOM ability in schizophrenic adolescents and revealed an association between TOM deficit and decreased GMV in regions which are crucial for social cognition, thereby provided insight and possible target regions for understanding the neural pathology and normalizing TOM deficit in adolescent schizophrenia patients., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Understanding dynamic future changes in precipitation can provide prior information for nonpoint source pollution simulations under global warming. However, the evolution of the dependence structure and the unevenness characteristics of precipitation are rarely considered. This study applied a two-stage bias correction to daily precipitation and max/min temperature data in the Daqing River Basin (DQRB) with the HadGEM3-RA climate model. Validated from 1981 to 2015, future scenarios under two emission paths covering 2031-2065 and 2066-2100 were projected to assess variations in both the amount and unevenness of precipitation. The results suggested that, overall, the two-stage bias correction could reproduce the marginal distributions of variables and the evolution process of the dependence structure. In the future, the amount of precipitation in the plains is expected to increase more than that in the mountains, while precipitation unevenness, as measured by relative entropy, shows a slight increase in the mountains and a decrease in the plains, with enhanced seasonality. Conditioned on rising temperatures, high-/low-intensity precipitation tends to intensify/weaken precipitation unevenness. Additionally, the potential application of the bias correction method used herein and the possible impacts of uneven precipitation on nonpoint source pollution are given for further analyses. This study can provide useful information for future nonpoint source pollution simulations in the DQRB., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

A temperature control curtain can effectively mitigate the negative effect of outflow temperature on the river eco-environment downstream. To investigate the response of outflow temperature to influence factors (i.e., installation position of temperature control curtain, submerged depth, temperature distribution, and outflow discharge), experiments were conducted in a nonlinearly stratified fluid. The important degree of influence factors was determined by entropy weight method. The results indicated that the effect extent of influence factors on the outflow temperature was temperature distribution, submerged depth, outflow discharge, and installation position in turn. The installation position had little effect on the outflow temperature. Increasing the outflow discharge could withdraw more warm water near the surface and increase the outflow temperature. The outflow temperature also rose with decreasing submerged depth, and more warm water above the temperature control curtain level tended to be extracted when the submerged depth was enough. Although the outflow temperature increased, its variation amplitude depended on the temperature gradient of temperature distribution and was not affected by the structural form of selective withdrawal. From the point of operation management, the minimum submerged depth was determined using sensitivity analysis to obtain maximum improvement of outflow temperature.

Artificial substrates (ASs) and floating treatment wetlands (FTWs) have been widely used in the treatment of polluted surface water. In fact, periphyton on ASs functions in nutrient removal, while the plant-periphyton complex functions in FTWs. However, the nutrient removal performance of the periphyton on ASs and the plant-periphyton complex in FTWs has not been systematically compared. Thus, ASs and FTWs were established in a mesocosm experiment to compare nitrogen and phosphorus removal between the two ecological treatment techniques. The results showed that the total nitrogen removal efficiency was 60.4% in the AS treatments and 65.3% in the FTWs, while the total phosphorus removal efficiency was 83.7% in the AS treatments and 39.45% in the FTWs. Periphyton on the ASs absorbed 2.5 g N m -2 and 0.85 g P m -2 , accounting for 20.8% of the N removal and 18.7% of the P removal. Sedimentation contributed to 71.3% of the N removal and 56.1% of the P removal in the AS treatments. For the plant-periphyton complex in the FTWs, 25.1% of the N and 53.0% of the P accumulated in plant tissue. Most of the reduced N (47.1%) was removed by other pathways, which was likely the effect of periphyton attached on plant roots and floating rafts. The nutrient removal efficiencies and pathways of AS and FTW treatments showed different characteristics, providing a reference for the selection of treatment measures for polluted surface water remediation.

The risk of water shortage caused by uncertainties, such as frequent drought, varied precipitation, multiple water resources, and different water demands, brings new challenges to the water transfer projects. Uncertainties exist for transferring water and local surface water; therefore, the relationship between them should be thoroughly studied to prevent water shortage. For more effective water management, an uncertainty-based water shortage risk assessment model (UWSRAM) is developed to study the combined effect of multiple water resources and analyze the shortage degree under uncertainty. The UWSRAM combines copula-based Monte Carlo stochastic simulation and the chance-constrained programming-stochastic multiobjective optimization model, using the Lunan water-receiving area in China as an example. Statistical copula functions are employed to estimate the joint probability of available transferring water and local surface water and sampling from the multivariate probability distribution, which are used as inputs for the optimization model. The approach reveals the distribution of water shortage and is able to emphasize the importance of improving and updating transferring water and local surface water management, and examine their combined influence on water shortage risk assessment. The possible available water and shortages can be calculated applying the UWSRAM, also with the corresponding allocation measures under different water availability levels and violating probabilities. The UWSRAM is valuable for mastering the overall multi-water resource and water shortage degree, adapting to the uncertainty surrounding water resources, establishing effective water resource planning policies for managers and achieving sustainable development.

Exposure time is an important characteristic for hydrodynamics that has simultaneous impacts on the biochemical processes in tidal systems. To eliminate man-made errors, decrease computational effort, and increase simulation efficiency, exposure time was evaluated under different hydrodynamic conditions for a bay to investigate the impact of the external domain on the accuracy of the computational results for exposure time. The exposure time was explicitly defined and computed using a hydrodynamic model and tracer experiments for a set of ten external domain sizes (EDS), five external domain lengths (EDL), and three special hydrodynamic conditions. The results indicated that the external domain had a significant influence on the exposure time, and the intensity of this influence was related to hydrodynamic conditions. The sensitivity of the exposure time to the external domain increased with increasing tidal range, while freshwater inflows decreased this sensitivity. However, the variation trends for exposure time with different EDS and EDL were independent of the hydrodynamic conditions. Considering the computational efficiency (maximum), the calculated error (minimum) of the exposure time, and the impact of the boundary conditions (minimum), the recommended EDS and EDL range from 9 to 13 times the initial domain size and 1.30 to 1.45 times the length in the bay, respectively. The research regarding exposure time and external domains not only helps to eliminate the errors caused by man-made factors and reduce the computational effort but also provides a reference for understanding the interrelationship between coastal waters, reciprocating flow, and the water environment.

Purpose: To evaluate the ability of strabismus surgery to improve the health-related quality of life (HRQOL) assessment scores of children with intermittent exotropia and their parents., Methods: For this prospective, randomized, parallel group study, 130 children (8-17 year of age) with intermittent exotropia were recruited and randomized to undergo either corrective strabismus surgery or active monitoring without surgery. Each child was accompanied by a parent. HRQOL was assessed with 3 intermittent exotropia questionnaires (IXTQ)--the child self-report, parental proxy report, and parental self-report--administered at enrollment and 3 months after intervention. The primary outcome was change in IXTQ score after 3 months for both groups., Results: At enrollment the scores of the surgery group (n = 63) and monitoring group (n = 57) did not differ significantly (P > 0.05). The sex of the reporting parent had no significant influence on the proxy or parental scores at enrollment or at 3 months (P > 0.05, multivariate analysis). Strabismus surgery significantly improved all parts of the IXTQ scores (P < 0.0001, repeated measures analysis of variance). No significant changes were found for the child scores at 3 months in the monitoring group (P = 0.33). However, the parental and proxy scores were significantly decreased (P < 0.0001)., Conclusions: Corrective strabismus surgery significantly improved the HRQOL scores of the children with intermittent exotropia and their parents., (Copyright © 2015 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.)

Selective withdrawal from a thermal stratified reservoir has been widely utilized in managing reservoir water withdrawal. Besides theoretical analysis and numerical simulation, model test was also necessary in studying the temperature of withdrawn water. However, information on the similarity theory of the withdrawn water temperature model remains lacking. Considering flow features of selective withdrawal, the similarity theory of the withdrawn water temperature model was analyzed theoretically based on the modification of governing equations, the Boussinesq approximation, and some simplifications. The similarity conditions between the model and the prototype were suggested. The conversion of withdrawn water temperature between the model and the prototype was proposed. Meanwhile, the fundamental theory of temperature distribution conversion was firstly proposed, which could significantly improve the experiment efficiency when the basic temperature of the model was different from the prototype. Based on the similarity theory, an experiment was performed on the withdrawn water temperature which was verified by numerical method.

Side-type orifice intake is a type of selective withdrawal facility used in managing reservoirs to mitigate the negative effects of low-temperature water. Based on the temperature data of a thermal stratified reservoir in China, an experiment was conducted in flume to study the influence of intake flow rate on withdrawn water temperature with different temperature distributions. Results indicated that withdrawn water temperature changed with different flow rates. The temperature change was determined by the water temperature gradients above and below the intake, whereas the change trend of temperature depended on the difference between the water temperature gradient above and below the intake. We likewise proposed a new equation with which the withdrawn water temperature of a thermal stratified reservoir using a side-type orifice could be calculated. These findings could be directly applied to the design and operation of side-type orifice intake in thermal stratified reservoirs.

Objective: To explore posttraumatic stress disorder (PTSD) positive screening and factors influencing the mental state in victims who were evacuated/were not evacuated from Wenchuan earthquake area within 1 month., Methods: The 3 groups included 235 victims who were not evacuated from Shifang territory (the incident scene, Group A), 44 victims who were evacuated to Second Xiangya Hospital (the wounded, Group B) and 36 relatives (the relatives, Group C). The mental state of all subjects was evaluated by Impact of Event Scale-Revised (IES-R) and other tools., Results: (1) One month after the disaster, and the positive rate of PTSD screening in these survivors was 35.56%, the positive rate in women was significantly higher than that in men (chi(2)=16.27,P<0.001). The positive rate of PTSD screening in Group A, Group B and Group C was 39.15%, 31.82%, and 16.67%, respectively, with significant difference (chi(2)(mh)=5.243,P<0.05). Among the three groups which met the diagnosis criterion of PTSD symptoms, the scores for "numbness/avoidance symptom"and "excessive arousing symptom"in Group A were significantly higher than those in Group B and C (P<0.01). (2) The scores for "anxiety"and "depression"and "psychosomatic"symptoms in Group A and Group B were significantly higher than those in Group C (P<0.05). (3) Gender, place of residence and evacuating from the earthquake area or not were factors of PTSD symptoms., Conclusion: One month after the earthquake, the victims suffered psychologically. PTSD symptoms, anxiety and depression symptoms were their major mental problems, more attention to especially women victims. The protection factors include dispersing victims to the secure place as soon as possible, expanding and strengthening society support. Early psychological interventions will help victims to raise their psychological endurance and prevent PTSD effectively.

This paper reports the successful preparation of core-shell hybrid nanocomposites by a 'grafting from' approach based on in situ atom transfer radical polymerization (ATRP) of methyl methacrylate (MMA) from titanate nanotubes (TNTs). Transmission electron microscope (TEM) images of the products provide direct evidence for the formation of a core-shell structure, possessing a hard core of TNTs and a soft shell of poly-MMA (PMMA). Fourier-transform infrared spectroscopy (FT-IR), hydrogen nuclear magnetic resonance ((1)H NMR), scanning electron microscopy (SEM), and thermal gravimetric analysis (TGA) were used to determine the chemical structure, morphology, and the grafted PMMA quantities of the resulting products. The grafted PMMA content was well controlled and increased with increasing monomer/initiator ratio. Further copolymerization of hydroxyethyl methacrylate (HEMA) with PMMA-coated TNTs as initiators was realized, illustrating the 'living' characteristics of the ATRP method used in this paper.

Molecular dynamics simulations for the liquid-vacuum interface of the ionic liquid 1-ethyl-3-methylimidazolium nitrate (EMIM+/NO3-) were performed for both electronically polarizable and nonpolarizable potential energy surfaces. The interfacial structural properties, such as the oscillation in the number density profile, the orientational ordering, and the local clustering in the interfacial region, were calculated. The simulations with both the polarizable and nonpolarizable model demonstrate the existence of an inhomogeneous interfacial structure normal to the surface layer. It was found for both models that the ethyl tail group on EMIM+ is likely to protrude outward from the surface. In the outmost surface layer, the cation is likely to lie on the surface with the imidazolium ring parallel to the interface, while there is a second region with enhanced density from that in the bulk where the cation preferably slants with the imidazolium ring tending to be perpendicular to the surface. The results also reveal that the electronic polarization effect is important for the ionic liquid interface. It is found that the cation is likely to be segregated at the ionic liquid surface for the polarizable model, while for the nonpolarizable model, the anion is found to be more likely to exhibit such behavior. The surface tension of the polarizable model (58.5 +/- 0.5 mN/m) is much smaller than that of the nonpolarizable model (82.7 +/- 0.6 mN/m), in better agreement with extrapolated experimental measurements on similar ionic liquid systems.