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949 results on '"David D. Roberts"'

301. TIP3 (Tec Interacting Protein-3 = SOCS1)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

302. TRAIL-R2 (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

303. CCN5: rCOP1, WISP-2, CTGF-L, HICP

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

304. Type II Interferon

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

305. TPD52 (Tumor Protein D52)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

306. c-MYC

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

307. CD38 Negative Kinase 2

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

308. CCN1: Cyr61, CEF10, ßIG-M1, IGFBP10, IGFBP-rP4

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

309. Cholecystokinin-1 Receptor: CCK-1 Receptor

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

310. CCN4: ELM-1, WISP-1

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

311. Cell Proliferation-Inducing Gene 17

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

312. Concertina (Drosophila melanogaster Homolog)

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

313. CK-I

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

314. Tumor Rejection Antigen gp96

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

315. TCP-1 and Cct1

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

316. CCN3: NOV, IGFBP9, IGFBP-rP3

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

317. Calcium-Activated Neutral Protease

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

318. Type II PIP Kinase

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

319. TMEM85 (Transmembrane Protein 85)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

320. Caspase Recruitment Domain Family, Member 11

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

321. Cell Surface Glycoprotein CD53

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

322. TFEB/Transcription Factor EB (AGS12)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

323. Casein Kinase-I

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

324. TRIF: TIR Domain–Containing Adaptor-Inducing Interferon β

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

325. C-Src Kinase

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

326. Tripartite Motif Protein 23

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

327. Toll-Like Receptor 3

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

328. TOB2 (Transducer of ERBB2 2)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

329. TRAIL-R1 (Tumor Necrosis Factor-Related Apoptosis-Inducing ligand Receptor 1)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

330. CREB (Cyclic AMP-Responsive Element-Binding Protein)

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

331. C-Terminal Src Kinase

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

332. CCN6: WISP-3

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

333. Cholecystokinin Type A Receptor

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

334. Crk-Associated Substrate (CAS)

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

335. Toll-Like Receptor 4 Adapter Protein

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

336. The 5-HT3 Receptor

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

337. Casein Kinase 2

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

338. Testis Determining Factor

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012

339. Chiffon (Drosophila)

Author

Frans van Roy, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, David W. Litchfield, Dave Boucher, Jean-Bernard Denault, Keiko Matsuda, Michisuke Yuzaki, Carlos Repeke, Thiago Garlet, Ana Paula Trombone, Gustavo Garlet, Elcia Maria Silveira, Andreia Vieira, Fernando Cunha, Satoshi Kubota, Masaharu Takigawa, Helena Soares, Sofia Nolasco, João Gonçalves, Armand Bensussan, Anne Marie-Cardine, Sumit Deswal, Wolfgang W. A. Schamel, Leopoldo Santos-Argumedo, Gail A. Bishop, Dima A. Decker, Bruce S. Hostager, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano, Yvonne Rosenstein, Pauline Johnson, Asanga Samarakoon, Amy E. Saunders, Kenneth W. Harder, David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg, Pedro A. Lazo, Ramiro Barcia, Hsin-Jung Wu, Natarajan Muthusamy, Subbarao Bondada, Shoshana Levy, Sudesh Pawaria, Robert J. Binder, Hisao Masai, Dongli Hu, Jill M. Lahti, Bernhard B. Singer, Richard Horuk, Laurence J. Miller, Jean Morisset, Anita R. Mistry, Christopher A. O’Callaghan, Angharad E. Fenton-May, Michael Reschen, Janet A. Willment, Gordon D. Brown, Leonard Rabinow, Scott A. Ness, Carl E. Creutz, Nan Yagishita-Kyo, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, Haruhiko Bito, Masato Okada, Heung-Chin Cheng, Mohammed Iqbal Hossain, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong, Banibrata Sen, Faye M. Johnson, Paula A. Pino, Astrid E. Cardona, Federico Paroni, Kathrin Maedler, and Randy Y. C. Poon

Published
2012

340. Purification of thrombospondin from human platelets

Author

David D. Roberts, Neng-Hua Guo, and JoAnne Cashel

Subjects
endocrine system, Thrombospondin, Cell growth, Motility, Biological activity, Cell Biology, Biology, Pathology and Forensic Medicine, Biochemistry, Gene expression, Platelet, Anatomy, Thrombospondins, Gene
Abstract

Thrombospondins are a rapidly growing family of adhesive proteins that have diverse activities to modulate cellular growth, motility, and gene expression. Thrombospondin-1 (TSP) was the first identified member of this family and is the major form of thrombospondin in human platelets. A method is described to prepare TSP from human platelets in biologically active form with minimal degradation or contamination with other platelet proteins.

Published
1994

341. Abstract B18: Thrombospondin-1 regulates carcinogenesis in an in vivo model of colorectal cancer

Author

David R. Soto Pantoja, David D. Roberts, Nicole Morris, Maria E. Torres, J. Michael Sipes, and Nancy J. Emenaker

Subjects
Cancer Research, Cancer prevention, Colorectal cancer, business.industry, Matricellular protein, Cancer, Mouse model of colorectal and intestinal cancer, medicine.disease, medicine.disease_cause, Oncology, Thrombospondin 1, Immunology, medicine, Cancer research, Carcinogenesis, business, Transcription factor
Abstract

According to the National Cancer Institute more than 140,000 people will be diagnosed in the United States with colorectal cancer this year alone. The adenomatus polyposis coli (APC) gene is frequently mutated in colorectal cancer, the APC-min mouse correspondingly is a widely used model for the study of this type of cancer. Studies indictate that the matricellular protein Thrombospondin 1 (TSP1) is lost during progression of colon cancer. To study the role of TSP1 in this disease we generated APC-min and TSP-/- APC-min mice. Our data indicates that expression of TSP1 in the APC-min mouse prevents the development of adenomas in the large intestine in mice fed a low fat diet. On the other hand lack of TSP1 increases tumor multiplicity in these mice, and up-regulates Ki67 in intestinal tissue. Moreover TSP-/- APC-min mice show 50% reduction in survival when compared to TSP+/+APC-min mice alone. Here we show that ADD1/SREBP1 a key transcription factor linking changes in nutritional status of certain genes that regulate systemic energy metabolism is upregulated only in the TSP null APC min/+ animals indicating and association with increased tumor aggressiveness. Together this data indicates that TSP1 regulates progression of colon carcinogenesis and define molecular targets of TSP1 in the prevention of colorectal cancer. Citation Format: David R. Soto Pantoja, Maria E. Torres, J. Michael Sipes, Nicole Morris, David D. Roberts, Nancy J. Emenaker. Thrombospondin-1 regulates carcinogenesis in an in vivo model of colorectal cancer. [abstract]. In: Proceedings of the Thirteenth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2014 Sep 27-Oct 1; New Orleans, LA. Philadelphia (PA): AACR; Can Prev Res 2015;8(10 Suppl): Abstract nr B18.

Published
2015

342. Hydrogen sulfide is an endogenous potentiator of T cell activation

Author

David D. Roberts, Evelyn A. Wang, Sukhbir Kaur, Thomas W. Miller, Daniel H. Fowler, Erica V. Stein, Serge Gould, Langston Lim, and Shoba Amarnath

Subjects
Interleukin 2, Antigens, Differentiation, T-Lymphocyte, CD4-Positive T-Lymphocytes, T cell, Immunology, Cystathionine beta-Synthase, Mice, Transgenic, Biology, Lymphocyte Activation, Biochemistry, Jurkat cells, TCIRG1, Jurkat Cells, Mice, Antigens, CD, medicine, Cytotoxic T cell, Animals, Humans, Lectins, C-Type, IL-2 receptor, Hydrogen Sulfide, Molecular Biology, Cell Proliferation, Air Pollutants, ZAP70, Cystathionine gamma-Lyase, Interleukin-2 Receptor alpha Subunit, CD28, Cell Biology, equipment and supplies, Cell biology, medicine.anatomical_structure, Gene Expression Regulation, Interleukin-2, medicine.drug
Abstract

H(2)S is an endogenous signaling molecule that may act via protein sulfhydrylation to regulate various physiological functions. H(2)S is also a byproduct of dietary sulfate metabolism by gut bacteria. Inflammatory bowel diseases such as ulcerative colitis are associated with an increase in the colonization of the intestine by sulfate reducing bacteria along with an increase in H(2)S production. Consistent with its increased production, H(2)S is implicated as a mediator of ulcerative colitis both in its genesis or maintenance. As T cells are well established mediators of inflammatory bowel disease, we investigated the effect of H(2)S exposure on T cell activation. Using primary mouse T lymphocytes (CD3+), OT-II CD4+ T cells, and the human Jurkat T cell line, we show that physiological levels of H(2)S potentiate TCR-induced activation. Nanomolar levels of H(2)S (50-500 nM) enhance T cell activation assessed by CD69 expression, interleukin-2 expression, and CD25 levels. Exposure of T cells to H(2)S dose-dependently enhances TCR-stimulated proliferation with a maximum at 300 nM (30% increase, p0.01). Furthermore, activation increases the capacity of T cells to make H(2)S via increased expression of cystathionine γ-lyase and cystathionine β-synthase. Disrupting this response by silencing these H(2)S producing enzymes impairs T cell activation, and proliferation and can be rescued by the addition of 300 nM H(2)S. Thus, H(2)S represents a novel autocrine immunomodulatory molecule in T cells.

Published
2011

344. sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration

Author

John M. Sipes, David D. Roberts, Jeffrey S. Rubin, Yoshiro Chuman, Svetlana A. Kuznetsova, Vladimir Wolf, Maria J. Calzada, Gema Martin-Manso, and Charles P. Xavier

Subjects
Cell, Amino Acid Motifs, Biophysics, Motility, Breast Neoplasms, Biochemistry, Article, Thrombospondin 1, Cell Line, Tumor, Nerve Growth Factor, medicine, Cell Adhesion, Humans, Breast, Cell adhesion, Molecular Biology, Glycoproteins, biology, Cell adhesion molecule, Wnt signaling pathway, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Cell biology, Fibronectin, medicine.anatomical_structure, biology.protein, Intercellular Signaling Peptides and Proteins, Female, Breast carcinoma
Abstract

Secreted frizzled-related protein (sFRP)-1 is a Wnt antagonist that inhibits breast carcinoma cell motility, whereas the secreted glycoprotein thrombospondin-1 stimulates adhesion and motility of the same cells. We examined whether thrombospondin-1 and sFRP-1 interact directly or indirectly to modulate cell behavior. Thrombospondin-1 bound sFRP-1 with an apparent Kd = 48 nM and the related sFRP-2 with a Kd = 95 nM. Thrombospondin-1 did not bind to the more distantly related sFRP-3. The association of thrombospondin-1 and sFRP-1 is primarily mediated by the amino-terminal N-module of thrombospondin-1 and the netrin domain of sFRP-1. sFRP-1 inhibited α3β1 integrin-mediated adhesion of MDA-MB-231 breast carcinoma cells to a surface coated with thrombospondin-1 or recombinant N-module, but not adhesion of the cells on immobilized fibronectin or type I collagen. sFRP-1 also inhibited thrombospondin-1-mediated migration of MDA-MB-231 and MDA-MB-468 breast carcinoma cells. Although sFRP-2 binds similarly to thrombospondin-1, it did not inhibit thrombospondin-1-stimulated adhesion. Thus, sFRP-1 binds to thrombospondin-1 and antagonizes stimulatory effects of thrombospondin-1 on breast carcinoma cell adhesion and motility. These results demonstrate that sFRP-1 can modulate breast cancer cell responses by interacting with thrombospondin-1 in addition to its known effects on Wnt signaling.

Published
2011

345. Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1

Author

Sukhbir Kaur, Lijuan Zhang, Svetlana A. Kuznetsova, Michael L. Pendrak, Martin J. Romeo, Zhuqing Li, David D. Roberts, and John M. Sipes

Subjects
T cell, Receptors, Antigen, T-Cell, Glycobiology and Extracellular Matrices, CD47 Antigen, Nerve Tissue Proteins, Perlecan, Biochemistry, Jurkat cells, Thrombospondin 1, chemistry.chemical_compound, Amyloid beta-Protein Precursor, Jurkat Cells, medicine, Serine, Cytotoxic T cell, Humans, Antigen-presenting cell, Molecular Biology, biology, ZAP70, Endothelial Cells, Cell Biology, Heparan sulfate, Molecular biology, medicine.anatomical_structure, Proteoglycan, chemistry, biology.protein, Heparitin Sulfate, Signal Transduction
Abstract

Cell surface proteoglycans on T cells contribute to retroviral infection, binding of chemokines and other proteins, and are necessary for some T cell responses to the matricellular glycoprotein thrombospondin-1. The major cell surface proteoglycans expressed by primary T cells and Jurkat T cells have an apparent M(r)200,000 and are modified with chondroitin sulfate and heparan sulfate chains. Thrombospondin-1 bound in a heparin-inhibitable manner to this proteoglycan and to a soluble form released into the medium. Based on mass spectrometry, knockdown, and immunochemical analyses, the proteoglycan contains two major core proteins as follows: amyloid precursor-like protein-2 (APLP2, apparent M(r) 230,000) and CD47 (apparent M(r)250,000). CD47 is a known thrombospondin-1 receptor but was not previously reported to be a proteoglycan. This proteoglycan isoform of CD47 is widely expressed on vascular cells. Mutagenesis identified glycosaminoglycan modification of CD47 at Ser(64) and Ser(79). Inhibition of T cell receptor signaling by thrombospondin-1 was lost in CD47-deficient T cells that express the proteoglycan isoform of APLP2, indicating that binding to APLP2 is not sufficient. Inhibition of CD69 induction was restored in CD47-deficient cells by re-expressing CD47 or an S79A mutant but not by the S64A mutant. Therefore, inhibition of T cell receptor signaling by thrombospondin-1 is mediated by CD47 and requires its modification at Ser(64).

Published
2011

346. Therapeutic Targeting of CD47 to Modulate Tissue Responses to Ischemia and Radiation

Author

Jeffrey S. Isenberg, David R. Soto-Pantoja, and David D. Roberts

Subjects
Pathology, medicine.medical_specialty, Cell signaling, Morpholino, business.industry, Matricellular protein, Ischemia, medicine.disease, Article, medicine.anatomical_structure, Fibrosis, medicine, Cancer research, Bone marrow, Stem cell, business, Reperfusion injury
Abstract

CD47 is a widely expressed cell surface receptor that serves as a counter-receptor for signal regulatory protein-α and as a receptor for the secreted matricellular protein thrombospondin-1. Thrombospondin-1 signaling through CD47 regulates cellular signaling pathways that control cell survival, growth, motility, mitochondrial biogenesis, arterial vasoactive responses to physiologic vasodilators and blood flow, and responsiveness to growth factors. Studies employing mice lacking either thrombospondin-1 or CD47 have revealed an important role for this receptor-ligand interaction in tissue responses to injury and stress. These null mice show enhanced recovery from soft tissue fixed ischemic injuries, ischemia reperfusion injuries, and radiation injuries. These studies have led to development of antisense strategies to locally or globally suppress CD47 gene expression. A translation-blocking CD47 morpholino improves tissue survival in skin flap and hindlimb fixed ischemia models, full thickness skin grafts, and a liver ischemia/reperfusion model of organ transplantation in mice. Furthermore, the benefits of morpholino treatment extend to aged mice and mice with dysregulated fat metabolism that characteristically exhibit impaired recovery from ischemic injuries. Activity of the morpholino was also demonstrated for treatment of ischemic injury in miniature pigs. Treatment with the CD47 morpholino protects mice from major effects of ionizing radiation including alopecia, deterioration of muscle function, soft tissue and cutaneous fibrosis, and loss of hematopoietic stem cells in bone marrow. Remarkably, the same treatment does not protect tumors but instead enhances their ablation by irradiation. We discuss prospects for further development of CD47 antisense therapeutics for clinical applications including reconstructive surgery, organ transplantation, angioplasty, and cancer.

Published
2011

347. Specific simple sugars promote chemotaxis and chemokinesis of corneal endothelial cells

Author

David R. Whikehart, Neng-Hua Guo, Vivian S. Zabrenetzky, David D. Roberts, Tikva Vogel, and Diane A. Blake

Subjects
Sucrose, Physiology, ATPase, medicine.medical_treatment, Clinical Biochemistry, Chemokinesis, Deoxyglucose, Ouabain, Cell Movement, Extracellular, medicine, Animals, Cells, Cultured, biology, Chemotaxis, Growth factor, Endothelium, Corneal, Blood Proteins, Cell Biology, Molecular biology, Fibronectins, Endothelial stem cell, Glucose, Biochemistry, Cell culture, biology.protein, Calcium, Cattle, Sodium-Potassium-Exchanging ATPase, medicine.drug
Abstract

Bovine corneal endothelial cells showed a strong migratory response to specific simple sugars (D-glucose and sucrose, but not L-glucose, sorbitol, lactose, or D-galactose) at concentrations above 10 mM. Checkerboard analysis of the migratory responses in modified Boyden chambers indicated both chemotactic and chemokinetic effects. Serum starvation of the cultures increased the chemotaxis towards D-glucose and 2-deoxy-D-glucose, but not towards sucrose. Migration to sucrose and glucose was inhibited by chelation of extracellular calcium or by inhibition of Na+,K+ ATPase with ouabain. To date, this migratory response has been found only in corneal endothelial cells. Neither human melanoma cells, human breast carcinoma cells, bovine aortic endothelial cells, nor bovine microvascular endothelial cells migrated towards simple sugars, although all cell types migrated toward fibronectin in chemotaxis assays. After 16–19 passages in culture, bovine corneal endothelial cells retained their ability to migrate towards fibronectin, but lost their ability to migrate towards sugars. This loss of migratory response was accompanied by a sevenfold decrease in Na+,K+ ATPase activity. Although loss of Na+,K+ ATPase activity accompanied the loss of migratory response, pretreatment of cell cultures with 25 mM glucose did not stimulate, but rather lowered Na+,K+ ATPase activity in low or high passage cultures. © 1993 Wiley-Liss, Inc.

Published
1993

348. Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin-binding domain and synthetic peptides from the type I repeats of thrombospondin

Author

Amos Panet, Diane A. Blake, Jacob Hartman, Simona Mendelovitz, Henry C. Krutzsch, Tikva Vogel, David D. Roberts, and Neng-Hua Guo

Subjects
Angiogenesis, Basic fibroblast growth factor, Endothelial cell chemotaxis, Biology, Biochemistry, Cornea, chemistry.chemical_compound, Cell Movement, Thrombospondin 1, Cell Adhesion, Animals, Humans, Amino Acid Sequence, Molecular Biology, Aorta, Thrombospondin, Binding Sites, Membrane Glycoproteins, Heparin, Epithelial Cells, Chemotaxis, DNA, Cell Biology, Peptide Fragments, Recombinant Proteins, Endothelial stem cell, Kinetics, chemistry, Cattle, Fibroblast Growth Factor 2, Endothelium, Vascular, Thrombospondins, Cell Division, Binding domain
Abstract

Thrombospondin is an inhibitor of angiogenesis that modulates endothelial cell adhesion, proliferation, and motility. Synthetic peptides from the second type I repeat of human thrombospondin containing the consensus sequence -Trp-Ser-Pro-Trp- and a recombinant heparin binding fragment from the amino-terminus of thrombospondin mimic several of the activities of the intact protein. The peptides and heparin-binding domain promote endothelial cell adhesion, inhibit endothelial cell chemotaxis to basic fibroblast growth factor (bFGF), and inhibit mitogenesis and proliferation of aortic and corneal endothelial cells. The peptides also inhibit heparin-dependent binding of bFGF to corneal endothelial cells. The antiproliferative activities of the peptides correlate with their ability to bind to heparin and to inhibit bFGF binding to heparin. Peptides containing amino acid substitutions that eliminate heparin-binding do not alter chemotaxis or proliferation of endothelial cells. Inhibition of proliferation by the peptide is time-dependet and reversible. Thus, the antiproliferative activities of the thrombospondin peptides and recombinant heparin-binding domain result at least in part from competition with heparin-dependent growth factors for binding to endothelial cell proteoglycans. These results suggest that both the Trp-Ser-Xaa-Trp sequences in the type I repeats and the amino-terminal domain play roles in the antiproliferative activity of thrombospondin.

Published
1993

349. Inhibition of fibronectin binding and fibronectin-mediated cell adhesion to collagen by a peptide from the second type I repeat of thrombospondin

Author

David D. Roberts, Tikva Vogel, John M. Sipes, Neng-Hua Guo, Eric Negre, and Henry C. Krutzsch

Subjects
animal structures, Molecular Sequence Data, Platelet Membrane Glycoproteins, Biology, Platelet membrane glycoprotein, Cell Line, Cell–cell interaction, Thrombospondin 1, Cell Adhesion, Humans, Amino Acid Sequence, Cell adhesion, Thrombospondins, Repetitive Sequences, Nucleic Acid, Thrombospondin, Binding Sites, Sequence Homology, Amino Acid, integumentary system, Articles, Cell Biology, Molecular biology, Fibronectins, Fibronectin, Fibronectin binding, biology.protein, Gelatin, Collagen, Peptides
Abstract

The platelet and extracellular matrix glycoprotein thrombospondin interacts with various types of cells as both a positive and negative modulator of cell adhesion, motility, and proliferation. These effects may be mediated by binding of thrombospondin to cell surface receptors or indirectly by binding to other extracellular matrix components. The role of peptide sequences from the type I repeats of thrombospondin in its interaction with fibronectin were investigated. Fibronectin bound specifically to the peptide Gly-Gly-Trp-Ser-His-Trp from the second type I repeat of thrombospondin but not to the corresponding peptides from the first or third repeats or flanking sequences from the second repeat. The two Trp residues and the His residue were essential for binding, and the two Gly residues enhanced the affinity of binding. Binding of the peptide and intact thrombospondin to fibronectin were inhibited by the gelatin-binding domain of fibronectin. The peptide specifically inhibited binding of fibronectin to gelatin or type I collagen and inhibited fibronectin-mediated adhesion of breast carcinoma and melanoma cells to gelatin or type I collagen substrates but not direct adhesion of the cells to fibronectin, which was inhibited by the peptide Gly-Arg-Gly-Asp-Ser. Thus, the fibronectin-binding thrombospondin peptide Gly-Gly-Trp-Ser-His-Trp is a selective inhibitor of fibronectin-mediated interactions of cells with collagen in the extracellular matrix.

Published
1993

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