136 results on '"Arias Z"'
Search Results
102. The HAWC Gamma-Ray Observatory: Observations of Cosmic Rays
- Author
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Hawc, Collaboration, Abeysekara, A. U., Alfaro, R., Alvarez, C., Álvarez, J. D., Arceo, R., Arteaga-Velázquez, J. C., Ayala Solares, H. A., Barber, A. S., Baughman, B. M., Bautista-Elivar, N., Belmont, E., Benzvi, S. Y., Berley, D., Bonilla Rosales, M., Braun, J., Caballero-Lopez, R. A., Caballero-Mora, K. S., Carramiñana, A., Castillo, M., Cotti, U., Cotzomi, J., Eduardo de la Fuente, León, C., Deyoung, T., Diaz Hernandez, R., Díaz-Vélez, J. C., Dingus, B. L., Duvernois, M. A., Ellsworth, R. W., Fernandez, A., Fiorino, D. W., Fraija, N., Galindo, A., Garfias, F., González, L. X., González, M. M., Goodman, J. A., Grabski, V., Gussert, M., Hampel-Arias, Z., Hui, C. M., Hüntemeyer, P., Imran, A., Iriarte, A., Karn, P., Kieda, D., Kunde, G. J., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., León Vargas, H., Linares, E. C., Linnemann, J. T., Longo, M., Luna-Garcia, R., Marinelli, A., Martinez, H., Martinez, O., Martínez-Castro, J., Matthews, J. A. J., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nava, J., Nellen, L., Newbold, M., Noriega-Papaqui, R., Oceguera-Becerra, T., Patricelli, B., Pelayo, R., Pérez-Pérez, E. G., Pretz, J., Rivière, C., Rosa-González, D., Salazar, H., Salesa, F., Sanchez, F. E., Sandoval, A., Santos, E., Schneider, M., Silich, S., Sinnis, G., Smith, A. J., Sparks, K., Springer, R. W., Taboada, I., Toale, P. A., Tollefson, K., Torres, I., Ukwatta, T. N., Villaseñor, L., Weisgarber, T., Westerhoff, S., Wisher, I. G., Wood, J., Yodh, G. B., Younk, P. W., Zaborov, D., Zepeda, A., and Zhou, H.
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astro-ph.HE ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Astrophysics::High Energy Astrophysical Phenomena ,Physics::Space Physics ,Astrophysics::Instrumentation and Methods for Astrophysics ,FOS: Physical sciences ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We describe measurements of GeV and TeV cosmic rays with the High-Altitude Water Cherenkov Gamma-Ray Observatory, or HAWC. The measurements include the observation of the shadow of the moon; the observation of small-scale and large-scale angular clustering of the TeV cosmic rays; the prospects for measurement of transient solar events with HAWC; and the observation of Forbush decreases with the HAWC engineering array and HAWC-30., Contributions to the 33rd International Cosmic Ray Conference, Rio de Janeiro, Brazil, July 2013
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- 2013
103. The HAWC Gamma-Ray Observatory: Dark Matter, Cosmology, and Fundamental Physics
- Author
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Hawc, Collaboration, Abeysekara, A. U., Alfaro, R., Alvarez, C., Álvarez, J. D., Arceo, R., Arteaga-Velázquez, J. C., Ayala Solares, H. A., Barber, A. S., Baughman, B. M., Bautista-Elivar, N., Belmont, E., Benzvi, S. Y., Berley, D., Bonilla Rosales, M., Braun, J., Caballero-Lopez, R. A., Caballero-Mora, K. S., Carramiñana, A., Castillo, M., Cotti, U., Cotzomi, J., Eduardo de la Fuente, León, C., Deyoung, T., Diaz Hernandez, R., Díaz-Vélez, J. C., Dingus, B. L., Duvernois, M. A., Ellsworth, R. W., Fernandez, A., Fiorino, D. W., Fraija, N., Galindo, A., Garfias, F., González, L. X., González, M. M., Goodman, J. A., Grabski, V., Gussert, M., Hampel-Arias, Z., Hui, C. M., Hüntemeyer, P., Imran, A., Iriarte, A., Karn, P., Kieda, D., Kunde, G. J., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., León Vargas, H., Linares, E. C., Linnemann, J. T., Longo, M., Luna-Garcia, R., Marinelli, A., Martinez, H., Martinez, O., Martínez-Castro, J., Matthews, J. A. J., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nava, J., Nellen, L., Newbold, M., Noriega-Papaqui, R., Oceguera-Becerra, T., Patricelli, B., Pelayo, R., Pérez-Pérez, E. G., Pretz, J., Rivière, C., Rosa-González, D., Salazar, H., Salesa, F., Sanchez, F. E., Sandoval, A., Santos, E., Schneider, M., Silich, S., Sinnis, G., Smith, A. J., Sparks, K., Springer, R. W., Taboada, I., Toale, P. A., Tollefson, K., Torres, I., Ukwatta, T. N., Villaseñor, L., Weisgarber, T., Westerhoff, S., Wisher, I. G., Wood, J., Yodh, G. B., Younk, P. W., Zaborov, D., Zepeda, A., and Zhou, H.
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astro-ph.HE ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Instrumentation and Methods for Astrophysics ,FOS: Physical sciences ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The High-Altitude Water Cherenkov Gamma Ray Observatory (HAWC) is designed to perform a synoptic survey of the TeV sky. The high energy coverage of the experiment will enable studies of fundamental physics beyond the Standard Model, and the large field of view of the detector will enable detailed studies of cosmologically significant backgrounds and magnetic fields. We describe the sensitivity of the full HAWC array to these phenomena in five contributions shown at the 33rd International Cosmic Ray Conference in Rio de Janeiro, Brazil (July 2013)., Comment: Contributions to the 33rd International Cosmic Ray Conference, Rio de Janeiro, Brazil, July 2013
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- 2013
- Full Text
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104. Milagro limits and HAWC sensitivity for the rate-density of evaporating Primordial Black Holes
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Abdo, A.A., primary, Abeysekara, A.U., additional, Alfaro, R., additional, Allen, B.T., additional, Alvarez, C., additional, Álvarez, J.D., additional, Arceo, R., additional, Arteaga-Velázquez, J.C., additional, Aune, T., additional, Ayala Solares, H.A., additional, Barber, A.S., additional, Baughman, B.M., additional, Bautista-Elivar, N., additional, Becerra Gonzalez, J., additional, Belmont, E., additional, BenZvi, S.Y., additional, Berley, D., additional, Bonilla Rosales, M., additional, Braun, J., additional, Caballero-Lopez, R.A., additional, Caballero-Mora, K.S., additional, Carramiñana, A., additional, Castillo, M., additional, Christopher, G.E., additional, Cotti, U., additional, Cotzomi, J., additional, de la Fuente, E., additional, De León, C., additional, DeYoung, T., additional, Diaz Hernandez, R., additional, Diaz-Cruz, L., additional, Díaz-Vélez, J.C., additional, Dingus, B.L., additional, DuVernois, M.A., additional, Ellsworth, R.W., additional, Fiorino, D.W., additional, Fraija, N., additional, Galindo, A., additional, Garfias, F., additional, González, M.M., additional, Goodman, J.A., additional, Grabski, V., additional, Gussert, M., additional, Hampel-Arias, Z., additional, Harding, J.P., additional, Hays, E., additional, Hoffman, C.M., additional, Hui, C.M., additional, Hüntemeyer, P., additional, Imran, A., additional, Iriarte, A., additional, Karn, P., additional, Kieda, D., additional, Kolterman, B.E., additional, Kunde, G.J., additional, Lara, A., additional, Lauer, R.J., additional, Lee, W.H., additional, Lennarz, D., additional, León Vargas, H., additional, Linares, E.C., additional, Linnemann, J.T., additional, Longo, M., additional, Luna-GarcIa, R., additional, MacGibbon, J.H., additional, Marinelli, A., additional, Marinelli, S.S., additional, Martinez, H., additional, Martinez, O., additional, Martínez-Castro, J., additional, Matthews, J.A.J., additional, McEnery, J., additional, Mendoza Torres, E., additional, Mincer, A.I., additional, Miranda-Romagnoli, P., additional, Moreno, E., additional, Morgan, T., additional, Mostafá, M., additional, Nellen, L., additional, Nemethy, P., additional, Newbold, M., additional, Noriega-Papaqui, R., additional, Oceguera-Becerra, T., additional, Patricelli, B., additional, Pelayo, R., additional, Pérez-Pérez, E.G., additional, Pretz, J., additional, Rivière, C., additional, Rosa-González, D., additional, Ruiz-Velasco, E., additional, Ryan, J., additional, Salazar, H., additional, Salesa, F., additional, Sandoval, A., additional, Saz Parkinson, P.M., additional, Schneider, M., additional, Silich, S., additional, Sinnis, G., additional, Smith, A.J., additional, Stump, D., additional, Sparks Woodle, K., additional, Springer, R.W., additional, Taboada, I., additional, Toale, P.A., additional, Tollefson, K., additional, Torres, I., additional, Ukwatta, T.N., additional, Vasileiou, V., additional, Villaseñor, L., additional, Weisgarber, T., additional, Westerhoff, S., additional, Williams, D.A., additional, Wisher, I.G., additional, Wood, J., additional, Yodh, G.B., additional, Younk, P.W., additional, Zaborov, D., additional, Zepeda, A., additional, and Zhou, H., additional
- Published
- 2015
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105. VAMOS: A pathfinder for the HAWC gamma-ray observatory
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Abeysekara, A.U., primary, Alfaro, R., additional, Alvarez, C., additional, Álvarez, J.D., additional, Ángeles, F., additional, Arceo, R., additional, Arteaga-Velázquez, J.C., additional, Avila-Aroche, A., additional, Ayala Solares, H.A., additional, Badillo, C., additional, Barber, A.S., additional, Baughman, B.M., additional, Bautista-Elivar, N., additional, Becerra Gonzalez, J., additional, Belmont, E., additional, Benítez, E., additional, BenZvi, S.Y., additional, Berley, D., additional, Bernal, A., additional, Bonilla Rosales, M., additional, Braun, J., additional, Caballero-Lopez, R.A., additional, Caballero-Mora, K.S., additional, Cabrera, I., additional, Carramiñana, A., additional, Castañeda-Martínez, L., additional, Castillo, M., additional, Cotti, U., additional, Cotzomi, J., additional, de la Fuente, E., additional, De León, C., additional, DeYoung, T., additional, Diaz-Azuara, A., additional, Diaz-Cruz, L., additional, Diaz Hernandez, R., additional, Díaz-Vélez, J.C., additional, Dingus, B.L., additional, Dultzin, D., additional, DuVernois, M.A., additional, Ellsworth, R.W., additional, Fernandez, A., additional, Fiorino, D.W., additional, Fraija, N., additional, Galindo, A., additional, García-Torales, G., additional, Garfias, F., additional, González, A., additional, González, L.X., additional, González, M.M., additional, Goodman, J.A., additional, Grabski, V., additional, Gussert, M., additional, Guzmán-Cerón, C., additional, Hampel-Arias, Z., additional, Harding, J.P., additional, Hernández-Cervantes, L., additional, Hui, C.M., additional, Hüntemeyer, P., additional, Imran, A., additional, Iriarte, A., additional, Karn, P., additional, Kieda, D., additional, Kunde, G.J., additional, Langarica, R., additional, Lara, A., additional, Lara, G., additional, Lauer, R.J., additional, Lee, W.H., additional, Lennarz, D., additional, León Vargas, H., additional, Linares, E.C., additional, Linnemann, J.T., additional, Longo, M., additional, Luna-Garcia, R., additional, Marinelli, A., additional, Martínez, L.A., additional, Martínez, H., additional, Martínez, O., additional, Martínez-Castro, J., additional, Martos, M., additional, Matthews, J.A.J., additional, McEnery, J., additional, Mendoza Torres, E., additional, Miranda-Romagnoli, P., additional, Moreno, E., additional, Mostafá, M., additional, Nava, J., additional, Nellen, L., additional, Newbold, M., additional, Noriega-Papaqui, R., additional, Oceguera-Becerra, T., additional, Page, D.P., additional, Patricelli, B., additional, Pelayo, R., additional, Pérez-Pérez, E.G., additional, Pretz, J., additional, Ramírez, I., additional, Rentería, A., additional, Rivière, C., additional, Rosa-González, D., additional, Ruiz-Sala, F., additional, Ruiz-Velasco, E.L., additional, Ryan, J., additional, Sacahui, J.R., additional, Salazar, H., additional, Salesa, F., additional, Sandoval, A., additional, Santos, E., additional, Schneider, M., additional, Silich, S., additional, Sinnis, G., additional, Smith, A.J., additional, Sparks Woodle, K., additional, Springer, R.W., additional, Suarez, F., additional, Taboada, I., additional, Tepe, A., additional, Toale, P.A., additional, Tollefson, K., additional, Torres, I., additional, Tinoco, S., additional, Ukwatta, T.N., additional, Valdés Galicia, J.F., additional, Vanegas, P., additional, Vázquez, A., additional, Villaseñor, L., additional, Wall, W., additional, Weisgarber, T., additional, Westerhoff, S., additional, Wisher, I.G., additional, Wood, J., additional, Yodh, G.B., additional, Younk, P.W., additional, Zaborov, D., additional, Zepeda, A., additional, and Zhou, H., additional
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- 2015
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106. Caracterización Epidemiológica y Toxicológica del Envenenamiento por Tityus Zulianus (Scorpiones, Buthidae) en el Estado Mérida, Venezuela
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Borges, A, Arandia, J, Colmenares De Arias, Z, Vargas, AM, and Alfonzo, MJ
- Subjects
Dosis Letal ,Scorpionism ,Lethal dose ,Escorpionismo ,Mérida ,Tityus - Abstract
El envenenamiento por escorpiones del género Tityus es causa de intoxicación grave y de muerte en niños menores de 8 años de edad en ciertos sectores del Estado Mérida. El tratamiento de estos casos requiere del uso de dosis elevadas del suero anti-Tityus discrepans. Con el fin de disectar geográficamente el problema, se revisaron los registros epidemiológicos regionales entre 1992 y 1998, revelándose un incremento sostenido de la tasa de incidencia en ese período para todo el Estado y la localización de la totalidad de los accidentes graves en los distritos sanitarios de El Vigía y Tovar. La especie más abundante del área endémica resultó Tityus zulianus González-Sponga, que habita desde el límite Zulia-Mérida-Trujillo hasta el norte de Táchira. Los valores de DL50 en ratones del veneno de T. zulianus provenientes de Tucaní (El Vigía) (1.68 mg/kg) y Mesa Bolívar (Tovar) (1.61 mg/kg) fueron similares, aunque no se descartan diferencias cualitativas y/o cuantitativas en la composición que puedan ser responsables de las diferencias clínicas observadas en los accidentes de ambas áreas. Envenomation by Tityus scorpions in Mérida State, western Venezuela, often produces respiratory distress and death in children under 8 years of age. Treatment usually requires large doses of the heterologous, anti-Tityus discrepans serum. To dissect the problem geographically, the records of scorpion sting cases held at the Epidemiology Division, Mérida Health Commission, were searched on a per sanitary district basis. The search revealed an increase in the total number of cases during 1992-98 and that the problem is restricted to El Vigía and Tovar sanitary districts, in or around villages located in the rain forest area south of Lake Maracaibo. The most abundant scorpion species was Tityus zulianus, which distribution area is hereby extended. No significant difference was found between the lethal dose in mice for T. zulianus venom from Tucaní (El Vigía district, 1.68 mg/kg) versus T. zulianus from Mesa Bolívar (Tovar district, 1.61 mg/kg) although quantitative and/or qualitative differences in composition cannot be dismissed, which could be responsible for the differences in the clinical outcome of cases from both districts.
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- 2002
107. Thevetin B: glicósido cardiotónico predominante en thevetia peruviana
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Amaringo Villa, Fredy, Hormaza A., Angelina, Arias Z., Mario, Amaringo Villa, Fredy, Hormaza A., Angelina, and Arias Z., Mario
- Abstract
El glicósido1 cardiotónico Thevetin B fue aislado, purificado, caracterizado y cuantificado como el componente principal en las hojas de Thevetia peruviana, especie vegetal difundida en la región del Valle del Aburrá. Las potenciales propiedades cardiotónicas descritas para este tipo de compuestos, lo convierten en una molécula de interés para el tratamiento de la insuficiencia cardíaca congestiva. Su purificación fue alcanzada mediante cromatografía de columna, su identificación estructural a través de espectroscopia de RMN y cromatografía líquida de alta resolución acoplada a masas (HPLC-MS) y su cuantificación por cromatogramas de HPLC haciendo uso del método de estándar externo.
- Published
- 2011
108. Sensitivity of the high altitude water Cherenkov detector to sources of multi-TeV gamma rays
- Author
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Abeysekara, A.U., primary, Alfaro, R., additional, Alvarez, C., additional, Álvarez, J.D., additional, Arceo, R., additional, Arteaga-Velázquez, J.C., additional, Ayala Solares, H.A., additional, Barber, A.S., additional, Baughman, B.M., additional, Bautista-Elivar, N., additional, Belmont, E., additional, BenZvi, S.Y., additional, Berley, D., additional, Bonilla Rosales, M., additional, Braun, J., additional, Caballero-Lopez, R.A., additional, Carramiñana, A., additional, Castillo, M., additional, Cotti, U., additional, Cotzomi, J., additional, de la Fuente, E., additional, De León, C., additional, DeYoung, T., additional, Diaz Hernandez, R., additional, Diaz-Velez, J.C., additional, Dingus, B.L., additional, DuVernois, M.A., additional, Ellsworth, R.W., additional, Fernandez, A., additional, Fiorino, D.W., additional, Fraija, N., additional, Galindo, A., additional, Garcia-Luna, J.L., additional, Garcia-Torales, G., additional, Garfias, F., additional, González, L.X., additional, González, M.M., additional, Goodman, J.A., additional, Grabski, V., additional, Gussert, M., additional, Hampel-Arias, Z., additional, Hui, C.M., additional, Hüntemeyer, P., additional, Imran, A., additional, Iriarte, A., additional, Karn, P., additional, Kieda, D., additional, Kunde, G.J., additional, Lara, A., additional, Lauer, R.J., additional, Lee, W.H., additional, Lennarz, D., additional, León Vargas, H., additional, Linares, E.C., additional, Linnemann, J.T., additional, Longo, M., additional, Luna-García, R., additional, Marinelli, A., additional, Martinez, O., additional, Martínez-Castro, J., additional, Matthews, J.A.J., additional, Miranda-Romagnoli, P., additional, Moreno, E., additional, Mostafá, M., additional, Nava, J., additional, Nellen, L., additional, Newbold, M., additional, Noriega-Papaqui, R., additional, Oceguera-Becerra, T., additional, Patricelli, B., additional, Pelayo, R., additional, Pérez-Pérez, E.G., additional, Pretz, J., additional, Rivière, C., additional, Ryan, J., additional, Rosa-González, D., additional, Salazar, H., additional, Salesa, F., additional, Sandoval, A., additional, Santos, E., additional, Schneider, M., additional, Silich, S., additional, Sinnis, G., additional, Smith, A.J., additional, Sparks, K., additional, Springer, R.W., additional, Taboada, I., additional, Toale, P.A., additional, Tollefson, K., additional, Torres, I., additional, Ukwatta, T.N., additional, Villaseñor, L., additional, Weisgarber, T., additional, Westerhoff, S., additional, Wisher, I.G., additional, Wood, J., additional, Yodh, G.B., additional, Younk, P.W., additional, Zaborov, D., additional, Zepeda, A., additional, and Zhou, H., additional
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- 2013
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109. On the sensitivity of the HAWC observatory to gamma-ray bursts
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Abeysekara, A.U., primary, Aguilar, J.A., additional, Aguilar, S., additional, Alfaro, R., additional, Almaraz, E., additional, Álvarez, C., additional, Álvarez-Romero, J. de D., additional, Álvarez, M., additional, Arceo, R., additional, Arteaga-Velázquez, J.C., additional, Badillo, C., additional, Barber, A., additional, Baughman, B.M., additional, Bautista-Elivar, N., additional, Belmont, E., additional, Benítez, E., additional, BenZvi, S.Y., additional, Berley, D., additional, Bernal, A., additional, Bonamente, E., additional, Braun, J., additional, Caballero-Lopez, R., additional, Cabrera, I., additional, Carramiñana, A., additional, Carrasco, L., additional, Castillo, M., additional, Chambers, L., additional, Conde, R., additional, Condreay, P., additional, Cotti, U., additional, Cotzomi, J., additional, D’Olivo, J.C., additional, de la Fuente, E., additional, De León, C., additional, Delay, S., additional, Delepine, D., additional, DeYoung, T., additional, Diaz, L., additional, Diaz-Cruz, L., additional, Dingus, B.L., additional, Duvernois, M.A., additional, Edmunds, D., additional, Ellsworth, R.W., additional, Fick, B., additional, Fiorino, D.W., additional, Flandes, A., additional, Fraija, N.I., additional, Galindo, A., additional, Garcı´a-Luna, J.L., additional, Garcı´a-Torales, G., additional, Garfias, F., additional, González, L.X., additional, González, M.M., additional, Goodman, J.A., additional, Grabski, V., additional, Gussert, M., additional, Guzmán-Ceron, C., additional, Hampel-Arias, Z., additional, Harris, T., additional, Hays, E., additional, Hernandez-Cervantes, L., additional, Hüntemeyer, P.H., additional, Imran, A., additional, Iriarte, A., additional, Jimenez, J.J., additional, Karn, P., additional, Kelley-Hoskins, N., additional, Kieda, D., additional, Langarica, R., additional, Lara, A., additional, Lauer, R., additional, Lee, W.H., additional, Linares, E.C., additional, Linnemann, J.T., additional, Longo, M., additional, Luna-García, R., additional, Martı´nez, H., additional, Martínez, J., additional, Martı´nez, L.A., additional, Martı´nez, O., additional, Martı´nez-Castro, J., additional, Martos, M., additional, Matthews, J., additional, McEnery, J.E., additional, Medina-Tanco, G., additional, Mendoza-Torres, J.E., additional, Miranda-Romagnoli, P.A., additional, Montaruli, T., additional, Moreno, E., additional, Mostafa, M., additional, Napsuciale, M., additional, Nava, J., additional, Nellen, L., additional, Newbold, M., additional, Noriega-Papaqui, R., additional, Oceguera-Becerra, T., additional, Olmos Tapia, A., additional, Orozco, V., additional, Pérez, V., additional, Pérez-Pérez, E.G., additional, Perkins, J.S., additional, Pretz, J., additional, Ramirez, C., additional, Ramírez, I., additional, Rebello, D., additional, Rentería, A., additional, Reyes, J., additional, Rosa-González, D., additional, Rosado, A., additional, Ryan, J.M., additional, Sacahui, J.R., additional, Salazar, H., additional, Salesa, F., additional, Sandoval, A., additional, Santos, E., additional, Schneider, M., additional, Shoup, A., additional, Silich, S., additional, Sinnis, G., additional, Smith, A.J., additional, Sparks, K., additional, Springer, W., additional, Suárez, F., additional, Suarez, N., additional, Taboada, I., additional, Tellez, A.F., additional, Tenorio-Tagle, G., additional, Tepe, A., additional, Toale, P.A., additional, Tollefson, K., additional, Torres, I., additional, Ukwatta, T.N., additional, Valdes-Galicia, J., additional, Vanegas, P., additional, Vasileiou, V., additional, Vázquez, O., additional, Vázquez, X., additional, Villaseñor, L., additional, Wall, W., additional, Walters, J.S., additional, Warner, D., additional, Westerhoff, S., additional, Wisher, I.G., additional, Wood, J., additional, Yodh, G.B., additional, Zaborov, D., additional, and Zepeda, A., additional
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- 2012
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110. 159. Perfusion computed tomography of human brain tumors: Quantitative assessment of cerebral blood flow, cerebral blood volume, time-to-peak and microvascular permeability: Report of four cases
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Bouza Domínguez, J., primary, Rodríguez Gutiérrez, K., additional, Aparicio Arias, Z., additional, Jordán González, J.A., additional, Fermín, E., additional, Nerey, A., additional, and Vila García, J.M., additional
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- 2008
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111. Aplicación de aspectos metodológicos para la evaluación de los esquemas de rutas urbanas. Caso ciudad de Sancti Spíritus.
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Parra, Arias Z. C., Auxiliar, Padilla, Magdaleno I., and Agregada
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URBAN transportation , *PASSENGER traffic , *PUBLIC transit , *BUS transportation , *URBAN planning , *TRANSPORTATION - Abstract
The article presents the methodological aspects used to evaluate the structure of the current scheme of urban routes from the technical and exploitation point of view. The aspects considered for the evaluation of the scheme of routes are related fundamentally with the planning of the urban space, the road network, the passengers´ movement (origin-destination of the trips), and technical and operational indicators which enable the analysis of the service level offered and at the same time to organize, to plan and to operatic the available resources in order to increase the offer to satisfy the population's demand and to improve the results in the enterprise management. The application of the indicators was validated in the urban public transportation service in Sancti Spíritus city. As a result it was proposed a new scheme of urban routes which combine technical, economic and productive indicators to be able to satisfy the demand with a better service level. [ABSTRACT FROM AUTHOR]
- Published
- 2011
112. Indicadores de evaluación en la operación del servicio interurbano de pasajeros por ómnibus. Una aplicación: Organización Económica Estatal de Transporte (OEET) "Mártires de Girón".
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Parra Arias, Z. and Padilla Magdaleno, I.
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PUBLIC transit , *TRANSPORTATION research , *BUS transportation , *BUSES , *PASSENGER traffic - Abstract
To evaluate the bus passenger transport operation they are used operational and technical indicators, which let us know some adequate information to improve the operations and the planning of activities in a certain period so as the level service. The objective of this paper is to achieve an analysis of the main indicators in order to evaluate the interurban passenger service by bus so as to show the similarity between them by the opinions of national and international authors. [ABSTRACT FROM AUTHOR]
- Published
- 2008
113. El contrato de mandato en la legislación ecuatoriana
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Morales Alvarez, Jorge, Arias Z., Manuel M., Morales Alvarez, Jorge, and Arias Z., Manuel M.
- Published
- 1988
114. The HAWC Gamma-Ray Observatory: Observations of Cosmic Rays
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Abeysekara, A. U., Alfaro, R., Alvarez, C., Álvarez, J. D., Arceo, R., Arteaga-Velázquez, J. C., Ayala Solares, H. A., Barber, A. S., Baughman, B. M., Bautista-Elivar, N., Belmont, E., Benzvi, S. Y., Berley, D., Rosales, M. Bonilla, Braun, J., Caballero-Lopez, R. A., Caballero-Mora, K. S., Carramiñana, A., Castillo, M., Cotti, U., Cotzomi, J., La Fuente, E., León, C., Deyoung, T., Diaz Hernandez, R., Díaz-Vélez, J. C., Dingus, B. L., Duvernois, M. A., Ellsworth, R. W., Fernandez, A., Fiorino, D. W., Fraija, N., Galindo, A., Garfias, F., González, L. X., González, M. M., Goodman, J. A., Grabski, V., Gussert, M., Hampel-Arias, Z., Hui, C. M., Hüntemeyer, P., Imran, A., Iriarte, A., Karn, P., Kieda, D., Kunde, G. J., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., Vargas, H. León, Linares, E. C., Linnemann, J. T., Longo, M., Luna-Garcia, R., Marinelli, A., Martinez, H., Martinez, O., Martínez-Castro, J., Matthews, J. A. J., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nava, J., Lukas Nellen, Newbold, M., Noriega-Papaqui, R., Oceguera-Becerra, T., Patricelli, B., Pelayo, R., Pérez-Pérez, E. G., Pretz, J., Rivière, C., Rosa-González, D., Salazar, H., Salesa, F., Sanchez, F. E., Sandoval, A., Santos, E., Schneider, M., Silich, S., Sinnis, G., Smith, A. J., Sparks, K., Springer, R. W., Taboada, I., Toale, P. A., Tollefson, K., Torres, I., Ukwatta, T. N., Villaseñor, L., Weisgarber, T., Westerhoff, S., Wisher, I. G., Wood, J., Yodh, G. B., Younk, P. W., Zaborov, D., Zepeda, A., and Zhou, H.
115. Towards a measurement of the e+ e- Flux above 1 TeV with HAWC
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Segev BenZvi, Fiorino, D., Hampel-Arias, Z., and Nisa, M. U.
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High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics::Instrumentation and Detectors ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Instrumentation and Methods for Astrophysics ,FOS: Physical sciences ,High Energy Physics::Experiment ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The High-Altitude Water Cherenkov (HAWC) Observatory records the air showers produced by cosmic rays and gamma rays at a rate of about 20 kHz. While the events observed by HAWC are 99.9% hadronic cosmic rays, this background can be strongly suppressed using topological cuts that preferentially select electromagnetic air showers. Using this capability of HAWC, we can create a sample of air showers dominated by gamma rays and cosmic electrons and positrons. HAWC is one of the few operating observatories capable of measuring showers produced by electron and positron primaries above 1 TeV, and can record these showers from two-thirds of the sky each day. We describe the sensitivity of HAWC to leptonic cosmic rays, and discuss prospects for the measurement of the combined $e^+e^-$ flux and possible approaches for positron and electron charge separation with the HAWC detector., Comment: Presented at the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. See arXiv:1508.03327 for all HAWC contributions
116. The HAWC Gamma-Ray Observatory: Design, Calibration, and Operation
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Hawc, Collaboration, Abeysekara, A. U., Alfaro, R., Alvarez, C., Álvarez, J. D., Arceo, R., Arteaga-Velázquez, J. C., Ayala Solares, H. A., Barber, A. S., Baughman, B. M., Bautista-Elivar, N., Belmont, E., Benzvi, S. Y., Berley, D., Bonilla Rosales, M., Braun, J., Caballero-Lopez, R. A., Caballero-Mora, K. S., Carramiñana, A., Castillo, M., Cotti, U., Cotzomi, J., Eduardo de la Fuente, León, C., Deyoung, T., Diaz Hernandez, R., Díaz-Vélez, J. C., Dingus, B. L., Duvernois, M. A., Ellsworth, R. W., Fernandez, A., Fiorino, D. W., Fraija, N., Galindo, A., Garfias, F., González, L. X., González, M. M., Goodman, J. A., Grabski, V., Gussert, M., Hampel-Arias, Z., Hui, C. M., Hüntemeyer, P., Imran, A., Iriarte, A., Karn, P., Kieda, D., Kunde, G. J., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., León Vargas, H., Linares, E. C., Linnemann, J. T., Longo, M., Luna-Garcia, R., Marinelli, A., Martinez, H., Martinez, O., Martínez-Castro, J., Matthews, J. A. J., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nava, J., Nellen, L., Newbold, M., Noriega-Papaqui, R., Oceguera-Becerra, T., Patricelli, B., Pelayo, R., Pérez-Pérez, E. G., Pretz, J., Rivière, C., Rosa-González, D., Salazar, H., Salesa, F., Sanchez, F. E., Sandoval, A., Santos, E., Schneider, M., Silich, S., Sinnis, G., Smith, A. J., Sparks, K., Springer, R. W., Taboada, I., Toale, P. A., Tollefson, K., Torres, I., Ukwatta, T. N., Villaseñor, L., Weisgarber, T., Westerhoff, S., Wisher, I. G., Wood, J., Yodh, G. B., Younk, P. W., Zaborov, D., Zepeda, A., and Zhou, H.
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High Energy Astrophysical Phenomena (astro-ph.HE) ,astro-ph.HE ,Physics::Instrumentation and Detectors ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Instrumentation and Methods for Astrophysics ,FOS: Physical sciences ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,Physics::Atmospheric and Oceanic Physics ,astro-ph.IM - Abstract
The High-Altitude Water Cherenkov Gamma Ray Observatory (HAWC) is under construction 4100 meters above sea level at Sierra Negra, Mexico. We describe the design and cabling of the detector, the characterization of the photomultipliers, and the timing calibration system. We also outline a next-generation detector based on the water Cherenkov technique., Contributions to the 33rd International Cosmic Ray Conference, Rio de Janeiro, Brazil, July 2013
117. VERITAS and Fermi -LAT Observations of TeV Gamma-Ray Sources Discovered by HAWC in the 2HWC Catalog
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Abeysekara, A. U., Archer, A., Benbow, W., Bird, R., Brose, R., Buchovecky, M., Buckley, J. H., Bugaev, V., Chromey, A. J., Connolly, M. P., Cui, W., Daniel, M. K., Falcone, A., Feng, Q., Finley, J. P., Fortson, L., Furniss, A., Hütten, M., Hanna, D., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kertzman, M., Kieda, D., Krause, M., Krennrich, F., Kumar, S., Lang, M. J., Lin, T. T. Y., McArthur, S., Moriarty, P., Mukherjee, R., O’Brien, S., Ong, R. A., Otte, A. N., Park, N., Petrashyk, A., Pohl, M., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rulten, C., Sadeh, I., Santander, M., Sembroski, G. H., Shahinyan, K., Sushch, I., Tyler, J., Wakely, S. P., Weinstein, A., Wells, R. M., Wilcox, P., Wilhelm, A., Williams, D. A., Williamson, T. J, Zitzer, B., Abdollahi, S., Ajello, M., Baldini, L., Barbiellini, G., Bastieri, D., Bellazzini, R., Berenji, B., Bissaldi, E., Blandford, R. D., Bonino, R., Bottacini, E., Brandt, T. J., Bruel, P., Buehler, R., Cameron, R. A., Caputo, R., Caraveo, P. A., Castro, D., Cavazzuti, E., Charles, E., Chiaro, G., Ciprini, S., Cohen-Tanugi, J., Costantin, D., Cutini, S., D’Ammando, F., Palma, F. De, Lalla, N. Di, Mauro, M. Di, Venere, L. Di, Domínguez, A., Favuzzi, C., Fegan, S. J., Franckowiak, A., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Giordano, F., Giroletti, M., Green, D., Grenier, I. A., Guillemot, L., Guiriec, S., Hays, E., Hewitt, J. W., Horan, D., Jóhannesson, G., Kensei, S., Kuss, M., Larsson, S., Latronico, L., Lemoine-Goumard, M., Li, J., Longo, F., Loparco, F., Lovellette, M. N., Lubrano, P., Magill, J. D., Maldera, S., Mazziotta, M. N., McEnery, J. E., Michelson, P. F., Mitthumsiri, W., Mizuno, T., Monzani, M. E., Morselli, A., Moskalenko, I. V., Negro, M., Nuss, E., Ojha, R., Omodei, N., Orienti, M., Orlando, E., Palatiello, M., Paliya, V. S., Paneque, D., Perkins, J. S., Persic, M., Pesce-Rollins, M., Petrosian, V., Piron, F., Porter, T. A., Principe, G., Rainò, S., Rando, R., Rani, B., Razzano, M., Razzaque, S., Reimer, A., Reimer, O., Reposeur, T., Sgrò, C., Siskind, E. J., Spandre, G., Spinelli, P., Suson, D. J., Tajima, H., Thayer, J. B., Thompson, D. J., Torres, D. F., Tosti, G., Troja, E., Valverde, J., Vianello, G., Vogel, M., Wood, K., Yassine, M., Alfaro, R., Álvarez, C., Álvarez, J. D., Arceo, R., Arteaga-Velázquez, J. C., Rojas, D. Avila, Solares, H. A. Ayala, Becerril, A., Belmont-Moreno, E., BenZvi, S. Y., Bernal, A., Braun, J., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Castillo, M., Cotti, U., Cotzomi, J., De León, S. Coutiño, León, C. De, Fuente, E. De La, Dichiara, S., Dingus, B. L., DuVernois, M. A., Díaz-Vélez, J. C., Engel, K., Enriquez-Rivera, O., Fiorino, D. W., Fleischhack, H., Fraija, N., García-González, J. A., Garfias, F., Muñoz, A. González, González, M. M., Goodman, J. A., Hampel-Arias, Z., Harding, J. P., Hernandez, S., Hernandez-Almada, A., Hona, B., Hueyotl-Zahuantitla, F., Hui, C. M., Hüntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kaufmann, S., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Luna-García, R., López-Coto, R., Malone, K., Marinelli, S. S., Martinez, O., Martinez-Castellanos, I., Martínez-Castro, J., Martínez-Huerta, H., Matthews, J. A., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Pelayo, R., Pretz, J., Pérez-Pérez, E. G., Ren, Z., Rho, C. D., Rivière, C., Rosa-González, D., Rosenberg, M., Ruiz-Velasco, E., Salazar, H., Greus, F. Salesa, Sandoval, A., Schneider, M., Arroyo, M. Seglar, Sinnis, G., Smith, A. J., Springer, R. W., Surajbali, P., Taboada, I., Tibolla, O., Tollefson, K., Torres, I., Ukwatta, T. N., Villaseñor, L., Weisgarber, T., Westerhoff, S., Wisher, I. G., Wood, J., Yapici, T., Yodh, G., Zepeda, A., and Zhou, H.
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13. Climate action - Abstract
The astrophysical journal 866(1), 24 (2018). doi:10.3847/1538-4357/aade4e, The High Altitude Water Cherenkov (HAWC) collaboration recently published their 2HWC catalog, listing 39 very high energy (VHE; >100 GeV) gamma-ray sources based on 507 days of observation. Among these, 19 sources are not associated with previously known teraelectronvolt (TeV) gamma-ray sources. We have studied 14 of these sources without known counterparts with VERITAS and Fermi-LAT. VERITAS detected weak gamma-ray emission in the 1 TeV–30 TeV band in the region of DA 495, a pulsar wind nebula coinciding with 2HWC J1953+294, confirming the discovery of the source by HAWC. We did not find any counterpart for the selected 14 new HAWC sources from our analysis of Fermi-LAT data for energies higher than 10 GeV. During the search, we detected gigaelectronvolt (GeV) gamma-ray emission coincident with a known TeV pulsar wind nebula, SNR G54.1+0.3 (VER J1930+188), and a 2HWC source, 2HWC J1930+188. The fluxes for isolated, steady sources in the 2HWC catalog are generally in good agreement with those measured by imaging atmospheric Cherenkov telescopes. However, the VERITAS fluxes for SNR G54.1+0.3, DA 495, and TeV J2032+4130 are lower than those measured by HAWC, and several new HAWC sources are not detected by VERITAS. This is likely due to a change in spectral shape, source extension, or the influence of diffuse emission in the source region., Published by IOP, Chicago, Ill. [u.a.]
118. All-particle cosmic ray energy spectrum measured by the HAWC experiment from 10 to 500 TeV
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Hawc, Collaboration, Alfaro, R., Alvarez, C., Arceo, R., Arteaga-Velázquez, J. C., Avila Rojas, D., Ayala Solares, H. A., Barber, A. S., Becerril, A., Belmont-Moreno, E., Benzvi, S. Y., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Castillo, M., Cotti, U., Cotzomi, J., Coutiño León, S., León, C., Eduardo de la Fuente, Diaz Hernandez, R., Dichiara, S., Dingus, B. L., Duvernois, M. A., Díaz-Vélez, J. C., Ellsworth, R. W., Enriquez-Rivera, O., Fiorino, D. W., Fleischhack, H., Fraija, N., García-González, J. A., González Muñoz, A., González, M. M., Goodman, J. A., Hampel-Arias, Z., Harding, J. P., Hernandez-Almada, A., Hinton, J., Hueyotl-Zahuantitla, F., Hui, C. M., Huntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kaufmann, S., Lara, A., Lauer, R. J., Lennarz, D., León Vargas, H., Linnemann, J. T., Longinotti, A. L., Raya, G. Luis, Luna-García, R., López-Cámara, D., López-Coto, R., Malone, K., Marinelli, S. S., Martinez, O., Martinez-Castellanos, I., Martínez-Castro, J., Martínez-Huerta, H., Matthews, J. A., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Pelayo, R., Pretz, J., Pérez-Pérez, E. G., Ren, Z., Rho, C. D., Rivière, C., Rosa-González, D., Rosenberg, M., Ruiz-Velasco, E., Salesa Greus, F., Sandoval, A., Schneider, M., Schoorlemmer, H., Sinnis, G., Smith, A. J., Springer, R. W., Surajbali, P., Taboada, I., Tibolla, O., Tollefson, K., Torres, I., Ukwatta, T. N., Villaseñor, L., Weisgarber, T., Westerhoff, S., Wood, J., Yapici, T., Zepeda, A., Zhou, H., and Álvarez, J. D.
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Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,HAWC - Abteilung Hinton ,Range (particle radiation) ,010308 nuclear & particles physics ,Astrophysics::High Energy Astrophysical Phenomena ,Gamma ray ,FOS: Physical sciences ,Cosmic ray ,Astrophysics ,01 natural sciences ,Power law ,Observatory ,0103 physical sciences ,Angular resolution ,Astrophysics - High Energy Astrophysical Phenomena ,010306 general physics ,Energy (signal processing) ,Cherenkov radiation - Abstract
We report on the measurement of the all-particle cosmic ray energy spectrum with the High Altitude Water Cherenkov (HAWC) Observatory in the energy range 10 to 500 TeV. HAWC is a ground based air-shower array deployed on the slopes of Volcan Sierra Negra in the state of Puebla, Mexico, and is sensitive to gamma rays and cosmic rays at TeV energies. The data used in this work were taken from 234 days between June 2016 to February 2017. The primary cosmic-ray energy is determined with a maximum likelihood approach using the particle density as a function of distance to the shower core. Introducing quality cuts to isolate events with shower cores landing on the array, the reconstructed energy distribution is unfolded iteratively. The measured all-particle spectrum is consistent with a broken power law with an index of $-2.49\pm0.01$ prior to a break at $(45.7\pm0.1$) TeV, followed by an index of $-2.71\pm0.01$. The spectrum also respresents a single measurement that spans the energy range between direct detection and ground based experiments. As a verification of the detector response, the energy scale and angular resolution are validated by observation of the cosmic ray Moon shadow's dependence on energy., Comment: 16 pages, 11 figures, 4 tables, submission to Physical Review D
119. The HAWC Gamma-Ray Observatory: Sensitivity to Steady and Transient Sources of Gamma Rays
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Abeysekara, A. U., Alfaro, R., Alvarez, C., Álvarez, J. D., Arceo, R., Arteaga-Velázquez, J. C., Ayala Solares, H. A., Barber, A. S., Baughman, B. M., Bautista-Elivar, N., Belmont, E., Benzvi, S. Y., Berley, D., Rosales, M. Bonilla, Braun, J., Caballero-Lopez, R. A., Caballero-Mora, K. S., Carramiñana, A., Castillo, M., Cotti, U., Cotzomi, J., La Fuente, E., León, C., Tyce DeYoung, Diaz Hernandez, R., Díaz-Vélez, J. C., Dingus, B. L., Duvernois, M. A., Ellsworth, R. W., Fernandez, A., Fiorino, D. W., Fraija, N., Galindo, A., Garfias, F., González, L. X., González, M. M., Goodman, J. A., Grabski, V., Gussert, M., Hampel-Arias, Z., Hui, C. M., Hüntemeyer, P., Imran, A., Iriarte, A., Karn, P., Kieda, D., Kunde, G. J., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., Vargas, H. León, Linares, E. C., Linnemann, J. T., Longo, M., Luna-Garcia, R., Marinelli, A., Martinez, H., Martinez, O., Martínez-Castro, J., Matthews, J. A. J., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nava, J., Nellen, L., Newbold, M., Noriega-Papaqui, R., Oceguera-Becerra, T., Patricelli, B., Pelayo, R., Pérez-Pérez, E. G., Pretz, J., Rivière, C., Rosa-González, D., Salazar, H., Salesa, F., Sanchez, F. E., Sandoval, A., Santos, E., Schneider, M., Silich, S., Sinnis, G., Smith, A. J., Sparks, K., Springer, R. W., Taboada, I., Toale, P. A., Tollefson, K., Torres, I., Ukwatta, T. N., Villaseñor, L., Weisgarber, T., Westerhoff, S., Wisher, I. G., Wood, J., Yodh, G. B., Younk, P. W., Zaborov, D., Zepeda, A., and Zhou, H.
120. The HAWC Gamma-Ray Observatory: Design, Calibration, and Operation
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Abeysekara, A. U., Alfaro, R., Alvarez, C., Álvarez, J. D., Arceo, R., Arteaga-Velázquez, J. C., Ayala Solares, H. A., Barber, A. S., Baughman, B. M., Bautista-Elivar, N., Belmont, E., Benzvi, S. Y., Berley, D., Rosales, M. Bonilla, Braun, J., Caballero-Lopez, R. A., Caballero-Mora, K. S., Carramiñana, A., Castillo, M., Cotti, U., Cotzomi, J., La Fuente, E., León, C., Tyce DeYoung, Diaz Hernandez, R., Díaz-Vélez, J. C., Dingus, B. L., Duvernois, M. A., Ellsworth, R. W., Fernandez, A., Fiorino, D. W., Fraija, N., Galindo, A., Garfias, F., González, L. X., González, M. M., Goodman, J. A., Grabski, V., Gussert, M., Hampel-Arias, Z., Hui, C. M., Hüntemeyer, P., Imran, A., Iriarte, A., Karn, P., Kieda, D., Kunde, G. J., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., Vargas, H. León, Linares, E. C., Linnemann, J. T., Longo, M., Luna-Garcia, R., Marinelli, A., Martinez, H., Martinez, O., Martínez-Castro, J., Matthews, J. A. J., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nava, J., Nellen, L., Newbold, M., Noriega-Papaqui, R., Oceguera-Becerra, T., Patricelli, B., Pelayo, R., Pérez-Pérez, E. G., Pretz, J., Rivière, C., Rosa-González, D., Salazar, H., Salesa, F., Sanchez, F. E., Sandoval, A., Santos, E., Schneider, M., Silich, S., Sinnis, G., Smith, A. J., Sparks, K., Springer, R. W., Taboada, I., Toale, P. A., Tollefson, K., Torres, I., Ukwatta, T. N., Villaseñor, L., Weisgarber, T., Westerhoff, S., Wisher, I. G., Wood, J., Yodh, G. B., Younk, P. W., Zaborov, D., Zepeda, A., and Zhou, H.
121. HAWC Contributions to the 34th International Cosmic Ray Conference (ICRC2015)
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Abeysekara, A. U., Alfaro, R., Alvarez, C., Álvarez, J. D., Arceo, R., Arteaga-Velázquez, J. C., Ayala Solares, H. A., Barber, A. S., Baughman, B. M., Bautista-Elivar, N., Becerra Gonzalez, J., Becerril, A., Belmont, E., Benzvi, S. Y., Berley, D., Bernal, A., Braun, J., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Castillo, M., Cotti, U., Cotzomi, J., León, S. Coutiño, La Fuente, E., León, C., Tyce DeYoung, Diaz Hernandez, R., Diaz-Cruz, L., Díaz-Vélez, J. C., Dingus, B. L., Duvernois, M. A., Ellsworth, R. W., Engel, K., Enriquez-Rivera, O., Fick, B., Fiorino, D. W., Flores, J. L., Fraija, N., Garcia-Torales, G., Garfias, F., González, M. M., Goodman, J. A., Gussert, M., Hampel-Arias, Z., Hansen, P., Harding, J. Patrick, Hernandez, S., Hui, C. M., Hüntemeyer, P., Imran, A., Iriarte, A., Karn, P., Kieda, D., Kunde, G. J., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., León Vargas, H., Linnemann, J. T., Proper, M. Longo, Raya, G. Luis, Luna-García, R., Malone, K., Marinelli, A., Marinelli, S. S., Martinez, H., Martinez, O., Martínez-Castro, J., Matthews, J. A. J., Mcenery, J., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nellen, L., Newbold, M., Nisa, M. Un, Noriega-Papaqui, R., Oceguera-Becerra, T., Patricelli, B., Pelayo, R., Pérez-Pérez, E. G., Pretz, J., Ren, Z., Rho, C. D., Rivière, C., Rosa-González, D., Ryan, J., Salazar, H., Salesa Greus, F., Sandoval, A., Schneider, M., Sinnis, G., Smith, A. J., Smith, A. W., Woodle, K. Sparks, Springer, R. W., Taboada, I., Tibolla, O., Toale, P. A., Tollefson, K., Torres, I., Ukwatta, T. N., Villaseñor, L., Weisgarber, T., Westerhoff, S., Wisher, I. G., Wood, J., Yapici, T., Yodh, G. B., Younk, P. W., Zepeda, A., and Zhou, H.
122. Multiwavelength follow-up of a rare IceCube neutrino multiplet
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Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Al Samarai, I., Altmann, D., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Archinger, M., Argüelles, C., Auffenberg, J., Axani, S., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K.-H., BenZvi, S., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Börner, M., Bos, F., Bose, D., Böser, S., Botner, O., Braun, J., Brayeur, L., Bretz, H.-P., Bron, S., Burgman, A., Carver, T., Casier, M., Cheung, E., Chirkin, D., Christov, A., Clark, K., Classen, L., Coenders, S., Collin, G. H., Conrad, J. M., Cowen, D. F., Cross, R., Day, M., De André, J. P. A. M., De Clercq, C., Del Pino Rosendo, E., Dembinski, H., De Ridder, S., Desiati, P., De Vries, K. D., De Wasseige, G., De With, M., DeYoung, T., Di Lorenzo, V., Dujmovic, H., Dumm, J. P., Dunkman, M., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eller, P., Euler, S., Evenson, P. A., Fahey, S., Fazely, A. R., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Flis, S., Fösig, C.-C., Franckowiak, A., Friedman, E., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Ghorbani, K., Giang, W., Gladstone, L., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Griffith, Z., Haack, C., Hallgren, A., Halzen, F., Hansen, E., Hansmann, T., Hanson, K., Hebecker, D., Heereman, D., Helbing, K., Hellauer, R., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoshina, K., Huang, F., Huber, M., Hultqvist, K., In, S., Ishihara, A., Jacobi, E., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Kang, W., Kappes, A., Karg, T., Karle, A., Katz, U., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kim, J., Kim, M., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Kohnen, G., Koirala, R., Kolanoski, H., Konietz, R., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Kroll, M., Krückl, G., Krüger, C., Kunnen, J., Kunwar, S., Kurahashi, N., Kuwabara, T., Kyriacou, A., Labare, M., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lesiak-Bzdak, M., Leuermann, M., Lu, L., Lünemann, J., Madsen, J., Maggi, G., Mahn, K. B. M., Mancina, S., Mandelartz, M., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Meier, M., Menne, T., Merino, G., Meures, T., Miarecki, S., Micallef, J., Momenté, G., Montaruli, T., Moulai, M., Nahnhauer, R., Naumann, U., Neer, G., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Olivas, A., O’Murchadha, A., Palczewski, T., Pandya, H., Pankova, D. V., Peiffer, P., Penek, Ö., Pepper, J. A., Pérez De Los Heros, C., Pieloth, D., Pinat, E., Price, P. B., Przybylski, G. T., Quinnan, M., Raab, C., Rädel, L., Rameez, M., Rawlins, K., Reimann, R., Relethford, B., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Sabbatini, L., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Sarkar, S., Satalecka, K., Schlunder, P., Schmidt, T., Schoenen, S., Schöneberg, S., Schumacher, L., Seckel, D., Seunarine, S., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stanev, T., Stasik, A., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Sutherland, M., Taavola, H., Taboada, I., Tatar, J., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Toscano, S., Tosi, D., Tselengidou, M., Tung, C. F., Turcati, A., Unger, E., Usner, M., Vandenbroucke, J., Van Eijndhoven, N., Vanheule, S., Van Rossem, M., Van Santen, J., Vehring, M., Voge, M., Vogel, E., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Waza, A., Weaver, Ch., Weiss, M. J., Wendt, C., Westerhoff, S., Whelan, B. J., Wickmann, S., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, T. R., Woolsey, E., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Zoll, M., Stanek, K. Z., Shappee, B. J., Kochanek, C. S., Holoien, T. W.-S., Prieto, J. L., Fox, D. B., DeLaunay, J. J., Turley, C. F., Barthelmy, S. D., Lien, A. Y., Mészáros, P., Murase, K., Kocevski, D., Buehler, R., Giomi, M., Racusin, J. L., Albert, A., Alfaro, R., Alvarez, C., Álvarez, J. D., Arceo, R., Arteaga-Velázquez, J. C., Ayala Solares, H. A., Barber, A. S., Baustista-Elivar, N., Becerril, A., Belmont-Moreno, E., Bernal, A., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Castillo, M., Cotti, U., Coutiño De León, S., De La Fuente, E., De León, C., Diaz Hernandez, R., Díaz-Vélez, J. C., Dingus, B. L., DuVernois, M. A., Ellsworth, R. W., Engel, K., Fiorino, D. W., Fraija, N., García-González, J. A., Gerhardt, M., González Muñoz, A., González, M. M., Goodman, J. A., Hampel-Arias, Z., Harding, J. P., Hernandez, S., Hui, C. M., Hüntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kaufmann, S., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., León Vargas, H., Linnemann, J. T., Luis Raya, G., Luna-García, R., López-Coto, R., Malone, K., Marinelli, S. S., Martinez, O., Martinez-Castellanos, I., Martínez-Castro, J., Martínez-Huerta, H., Matthews, J. A., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Pelayo, R., Pretz, J., Pérez-Pérez, E. G., Ren, Z., Rho, C. D., Rivière, C., Rosa-González, D., Rosenberg, M., Salesa Greus, F., Sandoval, A., Schneider, M., Schoorlemmer, H., Sinnis, G., Smith, A. J., Springer, R. W., Surajbali, P., Tibolla, O., Tollefson, K., Torres, I., Ukwatta, T. N., Villaseñor, L., Weisgarber, T., Wisher, I. G., Wood, J., Yapici, T., Zepeda, A., Zhou, H., Arcavi, I., Hosseinzadeh, G., Howell, D. A., Valenti, S., McCully, C., Lipunov, V. M., Gorbovskoy, E. S., Tiurina, N. V., Balanutsa, P. V., Kuznetsov, A. S., Kornilov, V. G., Chazov, V., Budnev, N. M., Gress, O. A., Ivanov, K. I., Tlatov, A. G., Rebolo Lopez, R., Serra-Ricart, M., Evans, P. A., Kennea, J. A., Gehrels, N., Osborne, J. P., Page, K. L., Abeysekara, A. U., Archer, A., Benbow, W., Bird, R., Brantseg, T., Bugaev, V., V Cardenzana, J., Connolly, M. P., Cui, W., Falcone, A., Feng, Q., Finley, J. P., Fleischhack, H., Fortson, L., Furniss, A., Griffin, S., Grube, J., Hütten, M., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Krause, M., Kumar, S., Lang, M. J., Lin, T. T. Y., McArthur, S., Moriarty, P., Mukherjee, R., Nieto, D., Ong, R. A., Otte, A. N., Pohl, Martin, Popkow, A., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rulten, C., Sadeh, I., Santander, M., Sembroski, G. H., Staszak, D., Trépanier, S., Tyler, J., Wakely, S. P., Weinstein, A., Wilcox, P., Wilhelm, A., Williams, D. A., Zitzer, B., Bellm, E., Cano, Z., Gal-Yam, A., Kann, D. A., Ofek, E. O., Rigault, M., and Soumagnac, M.
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13. Climate action ,7. Clean energy - Abstract
Astronomy and astrophysics 607, A115 (2017). doi:10.1051/0004-6361/201730620, On February 17, 2016, the IceCube real-time neutrino search identified, for the first time, three muon neutrino candidates arriving within 100 s of one another, consistent with coming from the same point in the sky. Such a triplet is expected once every 13.7 years as a random coincidence of background events. However, considering the lifetime of the follow-up program the probability of detecting at least one triplet from atmospheric background is 32%. Follow-up observatories were notified in order to search for an electromagnetic counterpart. Observations were obtained by Swift’s X-ray telescope, by ASAS-SN, LCO and MASTER at optical wavelengths, and by VERITAS in the very-high-energy gamma-ray regime. Moreover, the Swift BAT serendipitously observed the location 100 s after the first neutrino was detected, and data from the Fermi LAT and HAWC observatory were analyzed. We present details of the neutrino triplet and the follow-up observations. No likely electromagnetic counterpart was detected, and we discuss the implications of these constraints on candidate neutrino sources such as gamma-ray bursts, core-collapse supernovae and active galactic nucleus flares. This study illustrates the potential of and challenges for future follow-up campaigns., Published by EDP Sciences, Les Ulis
123. The HAWC Gamma-Ray Observatory: Dark Matter, Cosmology, and Fundamental Physics
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Abeysekara, A. U., Alfaro, R., Alvarez, C., Álvarez, J. D., Arceo, R., Arteaga-Velázquez, J. C., Ayala Solares, H. A., Barber, A. S., Baughman, B. M., Bautista-Elivar, N., Belmont, E., Benzvi, S. Y., Berley, D., Rosales, M. Bonilla, Braun, J., Caballero-Lopez, R. A., Caballero-Mora, K. S., Carramiñana, A., Castillo, M., Cotti, U., Cotzomi, J., La Fuente, E., León, C., Deyoung, T., Diaz Hernandez, R., Díaz-Vélez, J. C., Dingus, B. L., Duvernois, M. A., Ellsworth, R. W., Fernandez, A., Fiorino, D. W., Fraija, N., Galindo, A., Garfias, F., González, L. X., González, M. M., Goodman, J. A., Grabski, V., Gussert, M., Hampel-Arias, Z., Hui, C. M., Hüntemeyer, P., Imran, A., Iriarte, A., Karn, P., Kieda, D., Kunde, G. J., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., Vargas, H. León, Linares, E. C., Linnemann, J. T., Longo, M., Luna-Garcia, R., Marinelli, A., Martinez, H., Martinez, O., Martínez-Castro, J., Matthews, J. A. J., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nava, J., Lukas Nellen, Newbold, M., Noriega-Papaqui, R., Oceguera-Becerra, T., Patricelli, B., Pelayo, R., Pérez-Pérez, E. G., Pretz, J., Rivière, C., Rosa-González, D., Salazar, H., Salesa, F., Sanchez, F. E., Sandoval, A., Santos, E., Schneider, M., Silich, S., Sinnis, G., Smith, A. J., Sparks, K., Springer, R. W., Taboada, I., Toale, P. A., Tollefson, K., Torres, I., Ukwatta, T. N., Villaseñor, L., Weisgarber, T., Westerhoff, S., Wisher, I. G., Wood, J., Yodh, G. B., Younk, P. W., Zaborov, D., Zepeda, A., and Zhou, H.
124. Evaluación de un biorreactor de lecho empacado para el desarrollo del hongo Beauveria bassiana
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Zapata Zapata Arley David and Arias Zabala Mario
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Fermentación en estado sólido ,control biológico ,solid-state fermentation ,biological control ,Biotechnology ,TP248.13-248.65 - Abstract
La evaluación del biorreactor de lecho empacado para el desarrollo del hongo Beauveria bassiana se hizo con base en las variables temperatura y concentración de conidias, utilizando un sustrato sólido constituido por trigo entero. Se tomaron como parámetros de operación, la altura del lecho, el flujo de aire y la posición dentro del biorreactor, siendo el tiempo de fermentación un parámetro predeterminado que permitió monitorear las variables y comparar la productividad en el desarrollo del hongo. Se pudo observar, con ayuda de un diseño de experimentos factorial y una prueba de Tukey, que bajo ciertas condiciones de operación como una relación H/D = 0.9 (H: altura del lecho, D: diametro del biorreactor) y un flujo de aire de 12.3 L/min, se incrementó significativamente la productividad del hongo con respecto al método tradicional de producción (botellas) bajo la escala ensayada, siendo la posición un factor poco significativo en el proceso. Palabras clave: Fermentación en estado sólido, control biológico.
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- 2003
125. Cultivo de células vegetales en biorreactores:un sistema potencial para la producción de metabolitos secundarios.
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Orozco Sánches Fernando, Hoyos Sánchez Rodrigo, and Arias Zabala Mario E
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Metabolitos Secundarios ,Biorreactores ,Cultivo de Células Vegetales. ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
Los cultivos de células vegetales en biorreactores ofrecen un gran potencial para la producción de metabolitos secundarios, con importantes aplicaciones en la industria química, farmacéutica o alimenticia. Estos sistemas permiten controlar mejor la producción, a diferencia de los métodos tradicionales con plantaciones, los cuales presentan variaciones en la calidad y cantidad del producto debido a cambios climatológicos, estacionales, problemas geopolíticos o tenencia del suelo. Esta revisión presenta algunos grupos de metabolitos secundarios de plantas, su utilidad y ejemplos de sustancias con un potencial de producción al nivel comercial en cultivos celulares. Además, se presentan tres tipos de reactores (células en suspensión, células inmovilizadas y biopelículas de células), los problemas asociados con el cultivo de células vegetales y los factores que afectan la producción de los metabolitos secundarios. Los anteriores factores involucran la composición del medio de cultivo (sales inorgánicas, vitaminas, fuente de carbono, hormonas y reguladores de crecimiento), la composición del gas suministrado (oxígeno, bióxido de carbono, etileno), la temperatura, el pH, la radiación luminosa, las características de mezclado, la fase del crecimiento celular, el grado de diferenciación celular y la elicitación (biótica o abiótica). El estudio y la manipulación de los anteriores factores (variables operación) constituyen una etapa determinante para el diseño de un proceso que utilice esta tecnología como método de producción.
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- 2002
126. Uso alternativo de las frutas en preparación de mostos y fermentos.
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Ramírez Buitrago María Elvira and Arias Zabala Mario
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Mostos ,Fermentos ,Anaquel ,Fermentación alcohólica ,Deshidratación osmótica. ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
El presente trabajo busca establecer una técnica que permita aumentar la vida de anaquel por períodos prolongados de mostos y fermentos obtenidos de pulpas de frutas, para su aprovechamiento en la industria vinícola. Con este fin se realizó el estudio cinético de la fermentación alcohólica de pulpa de guayaba concentrada, aplicando dos tratamientos: mosto fresco y mosto conservado usando una combinación de métodos químicos y deshidratación osmótica. Se realizaron 18 fermentaciones, 9 para cada tratamiento, bajo control automático de las principales variables de operación, en proceso discontinuo y volumen de 12 litros. Se hizo el seguimiento, durante el proceso, de las concentraciones de sustrato, producto y biomasa durante 14 horas de fermentación, manteniendo el mismo valor de pH, concentración inicial de mosto, nutrientes y velocidad de agitación para todas las fermentaciones. Los valores de las variables correspondientes a la máxima productividad de alcohol fueron: temperatura 30°C, concentración inicial de sustrato, medido como azúcares reductores totales ART, 200 g/l y concentración de inóculo de 60 g/l. Dicha productividad máxima fue 7.39 g/l, habiéndose establecido que no existe diferencia estadísticamente significativa entre mosto fresco y mosto conservado.
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- 2000
127. Resolvin D2-induced reparative dentin and pulp stem cells after pulpotomy in a rat model.
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Yoneda M, Ideguchi H, Nakamura S, Arias Z, Ono M, Omori K, Yamamoto T, and Takashiba S
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Introduction: Vital pulp therapy (VPT) is performed to preserve dental pulp. However, the biocompatibility of the existing materials is of concern. Therefore, novel materials that can induce pulp healing without adverse effects need to be developed. Resolvin D2 (RvD2), one of specialized pro-resolving mediators, can resolve inflammation and promote the healing of periapical lesions. Therefore, RvD2 may be suitable for use in VPT. In the present study, we evaluated the efficacy of RvD2 against VPT using in vivo and in vitro models., Methods: First molars of eight-week-old male Sprague-Dawley rats were used for pulpotomy. They were then divided into three treatment groups: RvD2, phosphate-buffered saline, and calcium hydroxide groups. Treatment results were assessed using radiological, histological, and immunohistochemical (GPR18, TNF-α, Ki67, VEGF, TGF-β, CD44, CD90, and TRPA1) analyses. Dental pulp-derived cells were treated with RvD2 in vitro and analyzed using cell-proliferation and cell-migration assays, real-time PCR ( Gpr18 , Tnf-α , Il-1β , Tgf-β , Vegf , Nanog , and Trpa1 ), ELISA (VEGF and TGF-β), immunocytochemistry (TRPA1), and flow cytometry (dental pulp stem cells: DPSCs)., Results: The formation of calcified tissue in the pulp was observed in the RvD2 and calcium hydroxide groups. RvD2 inhibited inflammation in dental pulp cells. RvD2 promoted cell proliferation and migration and the expression of TGF-β and VEGF in vitro and in vivo . RvD2 increased the number of DPSCs. In addition, RvD2 suppressed TRPA1 expression as a pain receptor., Conclusion: RvD2 induced the formation of reparative dentin, anti-inflammatory effects, and decreased pain, along with the proliferation of DPSCs via the expression of VEGF and TGF-β, on the pulp surface in pulpotomy models., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Zulema Arias reports financial support was provided by 10.13039/501100001691Japan Society for the Promotion of Science. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)
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- 2024
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128. Hindsight2020: Characterizing Uncertainty in the COVID-19 Scientific Literature.
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Dobolyi K, Sieniawski GP, Dobolyi D, Goldfrank J, and Hampel-Arias Z
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- Humans, SARS-CoV-2, Uncertainty, Communication, Disease Outbreaks, COVID-19 epidemiology
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Following emerging, re-emerging, and endemic pathogen outbreaks, the rush to publish and the risk of data misrepresentation, misinterpretation, and even misinformation puts an even greater onus on methodological rigor, which includes revisiting initial assumptions as new evidence becomes available. This study sought to understand how and when early evidence emerges and evolves when addressing different types of recurring pathogen-related questions. By applying claim-matching by means of deep learning Natural Language Processing (NLP) of coronavirus disease 2019 (COVID-19) scientific literature against a set of expert-curated evidence, patterns in timing across different COVID-19 questions-and-answers were identified, to build a framework for characterizing uncertainty in emerging infectious disease (EID) research over time. COVID-19 was chosen as a use case for this framework given the large and accessible datasets curated for scientists during the beginning of the pandemic. Timing patterns in reliably answering broad COVID-19 questions often do not align with general publication patterns, but early expert-curated evidence was generally stable. Because instability in answers often occurred within the first 2 to 6 mo for specific COVID-19 topics, public health officials could apply more conservative policies at the start of future pandemics, to be revised as evidence stabilizes.
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- 2023
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129. Recent Advances in Apical Periodontitis Treatment: A Narrative Review.
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Arias Z, Nizami MZI, Chen X, Chai X, Xu B, Kuang C, Omori K, and Takashiba S
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Apical periodontitis is an inflammatory response caused by pulp infection. It induces bone resorption in the apical and periapical regions of the tooth. The most conservative approach to treat this condition is nonsurgical endodontic treatment. However, clinical failure has been reported with this approach; thus, alternative procedures are required. This review highlights recent literature regarding advanced approaches for the treatment of apical periodontitis. Various therapies, including biological medications, antioxidants, specialized pro-resolving lipid mediators, and stem cell therapy, have been tested to increase the success rate of treatment for apical periodontitis. Some of these approaches remain in the in vivo phase of research, while others have just entered the translational research phase to validate clinical application. However, a detailed understanding of the molecular mechanisms that occur during development of the immunoinflammatory reaction in apical periodontitis remains unclear. The aim of this review was to summarize advanced approaches for the treatment of apical periodontitis. Further research can confirm the potential of these alternative nonsurgical endodontic treatment approaches.
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- 2023
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130. Personalized Preclinical Training in Dental Ergonomics and Endodontics in Undergraduate Dentistry Students (Pilot Study).
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Arias Z, Haines S, Yamamoto T, Hatanaka K, Yamashiro K, Sonoi N, and Takashiba S
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- Humans, Pilot Projects, Curriculum, Ergonomics, Students, Dental, Endodontics
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The curriculum at the Department of Pathophysiology in the Periodontal Sciences program at Okayama University includes normative preclinical training (NPT) using phantoms. NPT is given to the whole class of 5 th year students divided in groups of 8 students/instructor. In 2019, an innovative personalized preclinical training (PPT) pilot study was implemented for this group of students whereby two students, each with their own dental unit, were coached by one instructor. The main topics covered were dental ergonomics and endodontics. We aimed to evaluate the effectiveness of PPT in dental ergonomics and endodontics toward increasing the knowledge and future clinical skills of students who had already undergone NPT. A test on endodontics was taken before and after PPT. A questionnaire was completed to assess their perception of improvement regarding the above-mentioned topics. Test scores and questionnaire results both showed that the students' level of knowledge and awareness of future clinical skills was significantly higher after PPT. This pilot study demonstrated that PPT increased the students' knowledge and future clinical skills. As preclinical training forms the foundation for clinical practice, investment in future research regarding this personalized approach is likely to enhance students' understanding and clinical performance., Competing Interests: No potential conflict of interest relevant to this article was reported.
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- 2023
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131. Reattachment of Fractured Tooth Fragment by Multidisciplinary Treatment Approach.
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Arias Z, Falú Hinojosa Ledezma H, Patricia Osorio Terán C, Omori K, Yamamoto T, Zahedul Islam Nizami M, and Takashiba S
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- Humans, Adult, Tooth Root injuries, Incisor, Esthetics, Dental, Root Canal Therapy, Tooth Crown, Dental Restoration, Permanent, Tooth Fractures therapy, Dental Bonding
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Dental anterior fractures are common injuries, especially in those who practice extreme sports. This report describes a 25-year-old Bolivian patient who attended our private dental clinic in La Paz, Bolivia after experiencing an accident during downhill mountain biking. An intraoral examination revealed a fracture line on the buccal side in the middle third of the coronal portion of the right central maxillary incisor which extended towards the proximal and lingual sides. Multidisciplinary treatment, including crown lengthening, osteotomy, root canal treatment, fiberglass post insertion, and reattachment of the fracture segment was performed. A follow-up examination at 10 months later revealed that the tooth was completely reestablished both functionally and esthetically and that there was no periapical pathosis or discomfort. This outcome suggests that if a patient seeks a dental consultation soon after a complex crown-root fracture has occurred, and if the broken tooth segment is available, then reattachment offers an economical and simple treatment option which will allow immediate restoration of functionality and esthetic standards. Continued follow-up should form part of such a treatment plan to allow long-term pulp vitality and periodontal health status to be monitored.
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- 2023
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132. Autophagy as a potential mechanism underlying the biological effect of 1,25-Dihydroxyvitamin D3 on periodontitis: a narrative review.
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Chen X, Arias Z, Omori K, Yamamoto T, Shinoda-Ito Y, and Takashiba S
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- Humans, Vitamin D, Autophagy, Inflammation, Calcitriol, Periodontitis
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The major active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D3), is known for its wide bioactivity in periodontal tissues. Although the exact mechanisms underlying its protective action against periodontitis remain unclear, recent studies have shown that 1,25D3 regulates autophagy. Autophagy is vital for intracellular pathogen invasion control, inflammation regulation, and bone metabolic balance in periodontal tissue homeostasis, and its regulation could be an interesting pathway for future periodontal studies. Since vitamin D deficiency is a worldwide health problem, its role as a potential regulator of autophagy provides new insights into periodontal diseases. Based on this premise, this narrative literature review aimed to investigate the possible connection between 1,25D3 and autophagy in periodontitis. A comprehensive literature search was conducted on PubMed using the following keywords (e.g., vitamin D, autophagy, periodontitis, pathogens, epithelial cells, immunity, inflammation, and bone loss). In this review, the latest studies on the protective action of 1,25D3 against periodontitis and the regulation of autophagy by 1,25D3 are summarized, and the potential role of 1,25D3-activated autophagy in the pathogenesis of periodontitis is analyzed. 1,25D3 can exert a protective effect against periodontitis through different signaling pathways in the pathogenesis of periodontitis, and at least part of this regulatory effect is achieved through the activation of the autophagic response. This review will help clarify the relationship between 1,25D3 and autophagy in the homeostasis of periodontal tissues and provide perspectives for researchers to optimize prevention and treatment strategies in the future., (© 2023. The Author(s).)
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- 2023
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133. Graphene Oxide-based Endodontic Sealer: An in Vitro Study.
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Nizami MZI, Gorduysus M, Shinoda-Ito Y, Yamamoto T, Nishina Y, Takashiba S, and Arias Z
- Subjects
- Humans, Anti-Bacterial Agents, Research Design, Materials Testing, Root Canal Filling Materials pharmacology, Graphite pharmacology
- Abstract
The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall., Competing Interests: No potential conflict of interest relevant to this article was reported.
- Published
- 2022
- Full Text
- View/download PDF
134. Microbiome composition comparison in oral and atherosclerotic plaque from patients with and without periodontitis.
- Author
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Isoshima D, Yamashiro K, Matsunaga K, Taniguchi M, Matsubara T, Tomida S, Ota S, Sato M, Shimoe Y, Kohriyama T, Arias Z, Omori K, Yamamoto T, and Takashiba S
- Subjects
- DNA, Bacterial genetics, Humans, Microbiota, Periodontitis, Plaque, Atherosclerotic
- Abstract
There is no conclusive evidence regarding a causal relationship between periodontitis and atherosclerosis. In this study, we examined the microbiome in the oral cavity and atheromatous plaques from atherosclerosis patients with or without periodontitis to investigate the role of oral bacteria in the formation of atheromatous plaques. We chose four patients with and without periodontitis, who had undergone carotid endarterectomy. Bacterial samples were extracted from the tongue surface, from periodontal pocket (during the oral examination), and from the atheromatous plaques (APs). We investigated the general and oral conditions from each patient and performed next-generation sequencing (NGS) analysis for all bacterial samples. There were no significant differences between both groups concerning general conditions. However, the microbiome patterns of the gingival pocket showed differences depending on the absence or presence of periodontitis, while those of the tongue surface were relatively similar. The microbiome pattern of the atheromatous plaques was entirely different from that on the tongue surface and gingival pocket, and oral bacteria were seldom detected. However, the microbiome pattern in atheromatous plaques was different in the presence or absence of periodontitis. These results suggested that oral bacteria did not affect the formation of atheromatous plaques directly.
- Published
- 2021
- Full Text
- View/download PDF
135. Formation and electrochemical characterization of 6-thioguanosine monolayers on the mercury surface.
- Author
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González Arias Z, Muñiz Alvarez JL, and López Fonseca JM
- Abstract
The interfacial and electrochemical behavior of 6-thioguanosine-6-thioguanine riboside (6TGR)-on a hanging mercury drop electrode was studied with ac and cyclic voltammetry in a solution of 0.1 M Na(2)SO(4) and 0.01 M sodium acetate buffer at pH 4.3. A self-assembled monolayer (SAM) of chemisorbed 6TGR molecules formed under determined adsorption conditions was characterized. A low-density monolayer of chemisorbed 6TGR molecules and a condensed monolayer of physisorbed ones, which are successively formed by reduction of the SAM, were also studied.
- Published
- 2006
- Full Text
- View/download PDF
136. Electrochemical characterization of a mixed self-assembled monolayer of 6-thioguanine and guanine on a mercury electrode.
- Author
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González Arias Z, Muñiz Alvarez JL, and López Fonseca JM
- Subjects
- Electrochemistry, Electrodes, Guanine chemistry, Mercury chemistry, Oxygen chemistry, Thioguanine chemistry
- Abstract
A monolayer constituted by chemisorbed 6-thioguanine and physisorbed guanine molecules was formed on a hanging mercury drop electrode from deoxygenated solutions of 6-thioguanine (6TG) and guanine (G). The mixed monolayer was characterized by chronoamperometry, cyclic voltammetry, and phase-sensitive ac voltammetry under in situ conditions, and the experimental data revealed a compact packing of molecules in the film. Ex situ measurements in the presence of dissolved oxygen proved that the mixed monolayer is stable in solutions lacking 6TG and G.
- Published
- 2004
- Full Text
- View/download PDF
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