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The article presents approaches to the definition and classification of knowledge in the tourism and hospitality industry from the standpoint of various groups of stakeholders in order to form a knowledge management algorithm and create knowledge systems adequate to the needs of tourist territories in the context of tourism development. A systematic approach to the formation and functioning of knowledge systems will provide solutions to the associated problems of sustainable tourism development, economic growth of businesses in the business community, and an increase in the attractiveness of tourist areas in accordance with the imperatives for the development of domestic and inbound tourism.

The properties of some organic materials in the removal of oil from water area were studied. It was shown that available materials as technical wool and sintepon can be used as effective sorbents for petroleum removal from water area. The sample mechanical wringing of these sorbents permits to return the part of adsorbed oil for its next use. The dependence of sorption properties (the adsorbed petroleum mass, specific oil adsorption, return of the oil and selectivity of petroleum removal) and petroleum removal from the number of absorption-release cycles was established. It was established that quantity of adsorbed oil decreases in other next step of removal but mass of oil returned increases in the process of mechanical wringing. The regeneration of these adsorbents by flushing in gasoline permits to obtained the initial properties in oil removal from water area. The sorption elements in the form of bags from linen with these materials were prepared. The dependence of the amount of oil removed by these sorption elements from the time of oil clearing of the water area process was determined and the optimal parameters of petroleum removal were established. It was shown that sorption elements on the base of these materials have adsorption capacity equal to 14-16 g of petroleum/g sorbent at selectivity of petroleum removal more than 70 % and oil recovery degree more than 80 % and the possibility their reusable use on oil spill response. The obtained positive results of oil removal from water area permit to propose in extreme cases of oil spills the available industrial products as jerseys, blankest, jackets etc. use successfully for petroleum spill response. The hydrophobization of these elements permits to improve their properties in oil removal from water area. As results of sorption elements modification the increase of adsorbed oil mass and specific petroleum removal at simultaneous increase of returned oil quantity for its next use and oil removal selectivity were established. It was established that synthesized sorption elements not inferior in properties known industrial sorbents for oil removal from water area.

Since the middle 1970s, the public has been seriously concerned about cases of school shooting — an armed attack by students on educational organizations. The global type of activity of social networks, as well as the high potential for the dissemination of destructive information in cyberspace with the use of anonymization, assigns digital resources, in fact, unlimited freedom of action. In this study, an attempt to semantic content analysis of digital destructive content of school shooting is made. The purpose of the study is to determine the system of signs of destructive content suitable for its identification in cyberspace through semantic analysis of the text openly published by users on the social network ‘Vkontakte’, using neural networks. The conducted research allowed us to identify a number of important signs of destructive content of school shooting with the allocation of thematic groups: indirect content of school shooting; drug content; mental distress.

Nowadays, the objects of forensic handwriting analysis are often become short handwritten records of elderly people and senile. The study of such records is one of the most difficult when conducting handwriting examination. This is due to the nature of this object, which is often subjected to changes due to insufficient written practice, influence of age-related changes in the body or conditions common for the elderly people and senile, frequent execution of short handwritten records in unusual conditions, and sometimes with the help of other people, limitations in the studied graphic material. The article attempts to substantiate and systematize theoretical knowledge on the study of short handwritten records executed by elderly and senile people through analyzing the literature and forensic practice on the study of this type of objects, establishing individual patterns of handwriting, explaining the nature of diagnostic signs occurrence, determining the structure of the process for solving the mentioned tasks. Cases from practice and related problematic aspects of solving identification and diagnostic tasks are considered. The main characteristics of impaired ability (sensory, amnestic and motor aphasia) to write are given. Literature sources are analyzed, which consider the physiological mechanisms of the formation of writing skills and the features of their changes due to various conditions in elderly and senile people. Handwriting can undergo changes owing to aging of the body. Disorder of hand-eye coordination, conditions of the musculoskeletal system, nervous system, circulatory disorders, inherent for elderly and senile people, affect the stability of handwriting features. Testaments, contracts of sale and donation, bank documents are often signed by people of elderly and senile age shortly before death resulting from a serious long illness after experiencing such conditions as stroke or myocardial infarction. It is the aging of the body that is accompanied by deterioration in the state of health, impaired vision, muscle weakness, depletion of the nervous system, decreased mobility of the musculoskeletal system and impaired blood circulation. Features of writing motor skill functioning in the elderly and senile people lead to a slowdown in the tempo of movement, decrease in their amplitude and speed, decrease in the plasticity of movements. The correct ratio of such signs as proficiency and coordination of movements is of great importance. In addition, short handwritten records executed by the elderly and senile people contain a limited amount of graphic material. At the moment of executing a short recording, even under normal conditions, the performer needs a certain adaptation to a situation, which can not be performed while rare or occasional execution of a single short record. Therefore, the stability of a skill while executing short recording has an increased spread, and selective variability has low thresholds.

Tissue plasminogen activator (tPA) is one of the key protein of plasminogen/plasmin system that converts plasminogen in the active proteinase plasmin. Platelets are able to bind both tPA and plasminogen on their surface, thus providing stimulatory effects on activation of zymogen. The present study was aimed to produce polyclonal antibodies against tPA and characterize their immunochemical capacities for further application in flow cytometry assay to study interaction between tPA and platelets. The experimental methods involved immunization of rabbit with tPA, collection of immune serum, synthesis of tPA-containing immunoaffine sorbent, ELISA, and flow cytometry. Polyclonal monospecific antibodies against tPA with high affinity to the antigen (Кd = 4.05・10–9 М) were obtained. Flow cytometry assay based on the use of the produced antibodies showed the presence of binding sites for tPA on the plasma membrane of inactive platelets. Moreover, agonist-stimulated platelets were revealed to expose more binding sites than their resting counterparts. Certain subpopulations of platelets that differ in the ability to bind tPA on their surface were also identified. Obtained data are of significant importance for further investigation of mechanisms underlying the role of platelets to regulate fibrinolytic rates.

Objective Ultra-high-field 7-Tesla (7T) magnetic resonance imaging (MRI) offers increased signal-to-noise and contrast-to-noise ratios, which may improve visualization of cortical malformations. We aim to assess the clinical value of in vivo structural 7T MRI and its post-processing for the noninvasive identification of epileptic brain lesions in patients with pharmacoresistant epilepsy and nonlesional 3T MRI who are undergoing presurgical evaluation. Methods Sixty-seven patients were included who had nonlesional 3T MRI by official radiology report. Epilepsy protocols were used for the 3T and 7T acquisitions. Post-processing of the 7T T1-weighted magnetization-prepared two rapid acquisition gradient echoes sequence was performed using the morphometric analysis program (MAP) with comparison to a normal database consisting of 50 healthy controls. Review of 7T was performed by an experienced board-certified neuroradiologist and at the multimodal patient management conference. The clinical significance of 7T findings was assessed based on intracranial electroencephalography (ICEEG) ictal onset, surgery, postoperative seizure outcomes, and histopathology. Results Unaided visual review of 7T detected previously unappreciated subtle lesions in 22% (15/67). When aided by 7T MAP, the total yield increased to 43% (29/67). The location of the 7T-identified lesion was identical to or contained within the ICEEG ictal onset in 13 of 16 (81%). Complete resection of the 7T-identified lesion was associated with seizure freedom (P = .03). Histopathology of the 7T-identified lesions encountered mainly focal cortical dysplasia (FCD). 7T MAP yielded 25% more lesions (6/24) than 3T MAP, and showed improved conspicuity in 46% (11/24). Significance Our data suggest a major benefit of 7T with post-processing for detecting subtle FCD lesions for patients with pharmacoresistant epilepsy and nonlesional 3T MRI.

Objective:to develop algorithm of independent groups comparison for nominal data of prospective non-randomized clinical trial AMIRI CABG (ClinicalTrials.gov Identifier: NCT03050489) using SAS Enterprise Guide 6.1. Materials and methods.Data collection was performed according to prospective non-randomized clinical trial AMIRI CABG in Pavlov First St. Petersburg State Medical University, Saint Petersburg, Russia between 2016-2019years with 336 patients. Patients were allocated into three groups of treatment. There is database which include following information: gender, myocardial infarction, stroke and postoperative bleeding. Comparison for nominal data (gender and incidence of myocardial infarction, stroke and bleeding) were calculated with SAS Enterprise Guide6.1 software with Chi-squared test and exact Fisher test. Results.There was developed algorithm of two independent groups comparison for nominal data. Conclusion.Presented algorithm of data analysis allows to compare independent groups for nominal data.

Objective: to develop algorithm of assessment of prognostic value of biomarker (troponin I) for predicting death after coronary artery bypass grafting. Materials and methods. Data collection was performed according to prospective non-randomized clinical trial AMIRI CABG in Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia between 20162019 years with 336 patients. There is database with clinical, laboratory and instrumental data. Statistics were calculated with SAS Enterprise Guide 6.1 software. Prognostic capability of biomarker for death were evaluated with logistic regression. Spline of relation between death and biomarker level were plotted using coefficient of logistic regression and intercept. Upper reference limit was calculated with Youden index. Results. There was developed algorithm to assess prognostic value of biomarker and its usefulness for clinical application and to define upper reference limit of biomarker. This algorithm could be useful for physicians and researchers for data analysis. Conclusion. Presented algorithm of data analysis allows to assess prognostic value of novel biomarker and its clinical usefulness.

The article shows that the activities of the State in the field of social support and social protection are aimed at addressing the needs of the lower levels of Maslow’s pyramid of motivation: physiological needs, the needs of a safe existence. Currently, we are fighting poverty, while we need to create conditions for the formation of an active life position of citizens, which is aimed at the development of the human capital of the country, on the quality of which the successes of modern society depend. This task is achieved by forming motivations of the highest levels of the pyramid: the need for social contacts, self-affirmation and self-expression. The development of the Concept and Program for Human Capital Development would allow to coordinate and link all activities of a socio-economic nature, both already being implemented in the country and formulated in the Address of the President to the Federal Assembly on January 15, 2020.

The analysis of the epidemic process associated with COVID-19 is carried out, possible scenarios of the development of events are presented. The most common anamnestic data, symptoms of infection, clinical picture and possible complications are described in detail. The features of the COVID-19 course in risk groups and the algorithms of administrative and medical actions that should underlie the provision of medical care to patients with cardiovascular, oncological, rheumatological diseases, pregnant women, etc. The section of diagnostics and examination features is of particular importance, since it includes not only the definition of the causative agent of the disease, but also the main indicators that determine the severity of the clinical picture, prognosis, the nature and extent of medical care. Considerable experience is presented in the clinical practice of computed tomography of the lungs, the method, the primary and early method for identifying not only lung lesions, but also the underlying disease — COVID-19. Information is presented from literary sources based on the experience of overcoming this formidable disease and its consequences by our colleagues, as well as the experience of domestic clinicians and scientists.

A formal model of an ecosystem, focused on software engineering, is proposed. Two approaches to the analysis of properties of this model, which are called network and automata approaches, are described. In particular, methods for finding optimal plan of job execution in an ecosystem, identification of emergency situations, possibility of paralell execution of problems are considered.

Two-staged treatment of arterio-portal fistula

Objective: to develop algorithm of correlation analysis of prospective non-randomized clinical trial AMIRICABG (ClinicalTrials.gov Identifier: NCT03050489) data using SAS Enterprise Guide 6.1. Materials and methods. Data collection was performed according prospective non-randomized clinical trial AMIRICABG (ClinicalTrials.gov Identifier: NCT03050489) in Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia between 20162019 years with 336 patients. There is database with clinical, laboratory and instrumental data. Correlation analysis was performed with SAS Enterprise Guide 6.1. Results. There was developed algorithm of correlation analysis data of prospective non-randomized clinical trial AMIRICABG (ClinicalTrials.gov Identifier: NCT03050489). This algorithm could be useful for physicians and researchers for data analysis. Conclusion. Presented algorithm of correlation analysis could make easier and improve efficient data analysis with SAS Enterprise Guide 6.1.

The interaction of the fifth kringle of Glu-plasminogen with fibrin triggers activation and initiation of fibrinolysis, yet the site on fibrin that binds kringle 5 remains unknown. The aim of our work was to determine an amino acid sequence in the D-fragment of fibrin(ogen) molecule, which is complementary to the lysine-binding site (LBS) in kringle 5. We studied the interaction between kringle 5 of plasminogen with polypeptide chains of the D-fragments of fibrin and cyanogen bromide fragments FCB-2 and t-NDSK and showed that kringle 5 bound specifically to α- and γ-chains of the D-fragment and the α-chain of FCB-2. Tryptic peptides of D-fragment α-chain were obtained, separated by their ability to bind with the immobilized kringle 5, and then all studied peptides were characterized by MALDI-TOF analysis. The critical amino acid residues of the α-chain of D-fragment, which provide its interaction with kringle 5, turned out to be α171Arg and/or α176Lys. The binding site of Glu-plasminogen complementary to the LBS of kringle 5 is located within Аα168Ala−183Lys, a sequence in a weakly structured loop between two supercoils in the α-chain of the D-fragment of the fibrin(ogen) molecule.

Relevance. Type-1 diabetes mellitus affects usual oral microbiome for active growth of periodontal pathogenic bacteria concentration in geometric progression, which leads to decrease in function of local immunity of oral cavity, inflammation of periodontal tissues and resorption of alveolar bone – the characteristics of chronic generalized periodontitis. This article provides analysis of qualitative and quantitative composition of microflora of periodontal pocket among type-1 diabetes patients before and after conservative periodontal therapy using ultrasonic treatment technique with a polishing suspension based on calcium hydroxide («Vector Paro», Durr Dental).Purpose. To evaluate the antibacterial effectiveness of professional oral hygiene complex with the additional treatment of periodontal pockets with «Vector Paro» device among patients with type-1 diabetes and chronic generalized mild periodontitis.Materials and methods. 30 patients with chronic generalized mild periodontitis and type-1 diabetes were examined with using analyses of periodontal pockets microflora contents. All patients underwent a standard complex of professional oral hygiene and gentle periodontal therapy with the «Vector Paro» device. Re-examination was in 4 weeks.Results. The performed complex of conservative periodontal therapy improved periodontal status in both groups, but in control group changes were more significant.Conclusion. Dynamic monitoring of qualitative and quantitative composition of periodontal pockets in combination with conservative periodontal therapy using the «Vector Paro» apparatus improves hygienic and periodontal status among patients with type-1 diabetes.

In general, magnetism and superconductivity are antagonistic to each other. However, there are several families of superconductors, in which superconductivity may coexist with magnetism, and only a few examples are known, when superconductivity itself induces spontaneous magnetism. The most known compounds are Sr$_2$RuO$_4$ and some noncentrosymmetric superconductors. Here, we report the finding of a narrow dome of a novel $s+is'$ superconducting (SC) phase with broken time-reversal symmetry (BTRS) inside the broad $s$-wave SC region of the centrosymmetric multiband superconductor Ba$_{\rm 1-x}$K$_{\rm x}$Fe$_2$As$_2$ ($0.7 \lesssim x \lesssim 0.85$). We observe spontaneous magnetic fields inside this dome using the muon spin relaxation ($\mu$SR) technique. Furthermore, our detailed specific heat study reveals that the BTRS dome appears very close to a change in the topology of the Fermi surface (Lifshitz transition). With this, we experimentally demonstrate the emergence of a novel quantum state due to topological changes of the electronic system., Comment: 28 pages, 11 figures

Objective: to develop algorithm of multiple comparisons data of prospective non-randomized clinical trial AMIRI CABG (ClinicalTrials.gov Identifier: NCT03050489) using SAS Enterprise Guide 6.1. Materials and methods. Data collection was performed according prospective non-randomized clinical trial AMIRI CABG in Pavlov First St. Petersburg State Medical University, Saint Petersburg, Russia between 20162019 years with 336 patients. There is database with clinical, laboratory and instrumental data. Multiple comparisons test was performed with SAS Enterprise Guide 6.1. Results. There was developed algorithm of multiple comparisons data of prospective non-randomized clinical trial AMIRI CABG for independent group. This algorithm could be useful for physicians and researchers for data analysis. Conclusion. Presented algorithm of data analysis could make easier and improve efficient data analysis. SAS Enterprise Guide 6.1 allows fast and accurate process data

Relevance. Processes of disturbance of regional hemodynamics, tissue blood flow, insufficiency of transcapillary metabolism and antioxidant system caused by dysfunction of periodontal vascular endothelium among patients with diabetes type 1 directly lead to diabetic microangiopathy accompanied by decrease of level of microcirculation and perfusion of periodontal tissues among patients with absolute insulin insufficiency. The reduction of linear and volumetric blood flow rates in periodontal vessels among patients with type 1 diabetes compared to values obtained by ultrasonic dopplerography in healthy patients can be considered as distinctive features of the manifestation of this systemic disease on microcirculation of periodontal tissues.Purpose. To evaluate the hemodynamics of periodontal vessels among patients with diabetes mellitus type 1 and without diabetes before and after conservative periodontal therapy.Materials and methods. 40 patients at the age 20-30 years were surveyed: 20 patients with diabetes mellitus type 1 and 20 patients without diabetes. All subjects underwent dental examination. To study the state of microcirculation of periodontal tissues patients of both groups underwent high-frequency ultrasound Doppler “Minimax-doppler-k”. Further was conducted professional oral hygiene complex with training in rules of individual oral hygiene. Reexamination was scheduled after 4 weeks. Results. During the conduction have been registered average baseline of the linear (Vam) and volumetric (Qam) blood flow in periodontal vessels in patients with diabetes mellitus type 1 and without diabetes. Average linear (Vam) and volumetric (Qam) blood flow before the conduction of professional oral hygiene complex were considerably lower compared to patients without diabetes. This points reduction of microcirculation and perfusion of periodontal tissues in patients with diabetes mellitus type 1 and without diabetes. Reassessment of blood flow in periodontal tissues in 4 weeks after professional oral hygiene revealed an increase in rate of microcirculation in periodontal tissues among patients with diabetes mellitus type 1 and without diabetes. Conclusion. Our study confirms the theory of hemodynamic impairment and local hemostasis in patients with type 1 diabetes, which is reflected in the appearance of trophic disorders of an inflammatory-dystrophic nature and a decrease in hemodynamic parameters. After conservative periodontal therapy, we revealed positive changes in hemodynamics of periodontal vessels, which was recorded using ultrasound dopplerography. Our results will allow us to select the optimal algorithms for the timely diagnosis, prevention and treatment of dental diseases in patients with type 1 diabetes in future.

Categories of rights and legitimate interests of a person are among the most essential in modern legal science, legislation and law enforcement practice. These categories are of particular importance in the field of criminal proceedings. The outcome of the preliminary investigation and trial in criminal cases largely depends on the correct understanding and subsequent application of these categories. The state should not only recognize, but also guarantee the possibility to exercise the rights and legitimate interests of an individual, enshrined at various levels, up to the international law. The study of the use of the legal concept of «personality» in various areas of law, including criminal procedure, indicates its application in the widest sense as a synonym for the concept of «a human». The law refers to a human as a person, regardless of the capacity in which he acts in specific legal relations. Categories «human», «individual», «personality», «person», «citizen» in the field of criminal proceedings can be considered synonymous. Some special characteristics arise not from differences in the general social status, but solely from the specific procedural status granted to a person in connection with criminal proceedings. In the research publications, the words «rights» and «freedoms» of the individual are considered identical, i.e. synonyms, and are described through the category of «opportunities». But for the recognition of such opportunities, it is not always required for them to be enshrined in the criminal procedure law. The category of «legitimate interest» has a specific meaning and differs from the categories of «rights and freedoms» of an individual. Legitimate interests are not indicated in the law itself because their scope of application is wider than the scope of law implementation. But such interests should not contradict the law, i.e. the provisions of the current legislation. A fundamental change in states perception of the individual has led to a significant change of the doctrine and content of criminal proceedings aimed primarily at protecting the rights and legitimate interests of the individual.

Platelets store, produce and release a variety of angiogenesis regulators, which can contribute to both normal tissue repair and angiopathy-associated pathologies. Plasminogen has been earlier shown to regulate some platelet functions, but if it is able to modulate angiogenic capacities of platelets is still poorly studied. Thus, the aim of the present study was to evaluate the effects of different plasminogen forms on the formation and secretion of angiogenic protein regulators by platelets. Human washed platelets were obtained by gel-filtration on Sepharose-2B. The levels of P-selectin (CD-62P) exposed on the plasma membrane of untreated and activated platelets was monitored by flow cytometry. Secretion of platelet-derived vascular endothelial growth factor (VEGF) as well as plasminogen fragmentation and angiostatin formation by intact platelets and platelet plasma membranes were analyzed by immunoblotting. It was shown that thrombin or collagen exposure resulted in enhanced P-selectin surface expression by platelets, while Lys-form of plasminogen reduced agonist-induced platelet secretion. Lys-plasminogen, but not Glu-form, inhibited agonist-induced VEGF release from platelets. Activation of platelets significantly accelerated plasminogen cleavage and angiostatin formation. Anti-actin antibodies inhibited plasminogen fragmentation during incubation with platelet plasma membranes indicating surface-exposed actin participation in plasminogen conversion to angiostatins. The present study uncovers a novel function of plasminogen to limit angiogenic potential of platelets via angiostatin formation and inhibition of VEGF secretion.

Objective: This paper covers the influence of the COVID-19 pandemic on bank activity and bank development which is aimed at ensuring competitiveness and stability of the Russian bank system. The aim of this paper is to study the results of bank activity and areas for further development of Russian banks under the COVID-19 pandemic. Methods: The study was conducted on the basis of a systematic and integrated approach with a set of general scientific and private scientific methods. Results: It is crucial to integrate risk management in business strategy and management systems of Russian banks, to combine accurate and reliable planning and forecasting in banking, to ensure efficient management of spending so as to increase operational efficiency and cost-effectiveness based on digital technology. Conclusions: The main approach to risks management should be holistic, comprehensive, and timely implemented into banking activity to ensure its stability and competitiveness in the long run.

Nowadays, wireless technologies are increasingly being used for human needs. Increasingly, technologies are emerging that are used by people not only for the need to transfer data. One of these technologies is the Internet of Things, which often uses wireless sensors with ZigBee data transmission technology as end devices.There are areas that require deployment of these networks on the territory, a large number of sensors are required, which must with sufficient accuracy “know” their position on the deployment area. Usually, devices with built-in GPS modules are used for this, but devices containing this module are significantly more expensive than without it. And if in a large distributed network with many segments, more than 1000 such devices are required, then a device with a GPS module can only be at most one for each segment. Therefore, if this is a forest where there are many thousands of trees and it is necessary to monitor fires at the initial stage, which take place in many US states in the summer, then the cognitive task of teaching those devices, that do not contain a GPS module, to determine their position is relevant. This paper proposes a mathematical formulation of the cognitive task of learning to determine the coordinates of devices in wireless sensor networks. The study of the mathematical model has been carried out. The purpose of these studies was to find new alternative teaching methods for determining the distance between objects of IoT sensor networks, using the function of localizing objects where an emergency occurred.

Nematicity in heavily hole-doped iron pnictide superconductors remains controversial. Sizeable nematic fluctuations and even nematic orders far from magnetic instability were declared in RbFe2As2and its sister compounds. Here, we report a systematic elastoresistance study of a series of isovalent- and electron-doped KFe2As2crystals. We found divergent elastoresistance on cooling for all the crystals along their [110] direction. The amplitude of elastoresistivity diverges if K is substituted with larger ions or if the system is driven toward a Lifshitz transition. However, we conclude that none of them necessarily indicates an independent nematic critical point. Instead, the increased nematicity can be associated with another electronic criticality. In particular, we propose a mechanism for how elastoresistivity is enhanced at a Lifshitz transition.

Significance During infection, extracellular “labile” heme, released from damaged red blood or parenchymal cells, acts as prototypical alarmin stimulating myeloid cells. A characteristic hallmark of myeloid cell activation is the development of trained immunity, specified as long-lasting adaptations based on transcriptional and epigenetic modifications. In vivo, this is maintained by the rerouting of hematopoiesis. We found that heme is a previously unrecognized trained immunity inducer promoting resistance to bacterial infection in mice. This goes along with extensive long-lasting epigenetic memory in hematopoietic stem cells provoking drastic changes in the transcription factor–binding landscape of myeloid progenitor cells. Given the critical role of heme during infections, we propose that trained immunity is a more general component of innate immunity than previously suggested., Trained immunity defines long-lasting adaptations of innate immunity based on transcriptional and epigenetic modifications of myeloid cells and their bone marrow progenitors [M. Divangahi et al., Nat. Immunol. 22, 2–6 (2021)]. Innate immune cells, however, do not exclusively differentiate between foreign and self but also react to host-derived molecules referred to as alarmins. Extracellular “labile” heme, released during infections, is a bona fide alarmin promoting myeloid cell activation [M. P. Soares, M. T. Bozza, Curr. Opin. Immunol. 38, 94–100 (2016)]. Here, we report that labile heme is a previously unrecognized inducer of trained immunity that confers long-term regulation of lineage specification of hematopoietic stem cells and progenitor cells. In contrast to previous reports on trained immunity, essentially mediated by pathogen-associated molecular patterns, heme training depends on spleen tyrosine kinase signal transduction pathway acting upstream of c-Jun N-terminal kinases. Heme training promotes resistance to sepsis, is associated with the expansion of self-renewing hematopoetic stem cells primed toward myelopoiesis and to the occurrence of a specific myeloid cell population. This is potentially evoked by sustained activity of Nfix, Runx1, and Nfe2l2 and dissociation of the transcriptional repressor Bach2. Previously reported trained immunity inducers are, however, infrequently present in the host, whereas heme abundantly occurs during noninfectious and infectious disease. This difference might explain the vanishing protection exerted by heme training in sepsis over time with sustained long-term myeloid adaptations. Hence, we propose that trained immunity is an integral component of innate immunity with distinct functional differences on infectious disease outcome depending on its induction by pathogenic or endogenous molecules.