272 results on '"Yoshio Minabe"'
Search Results
252. Lower Gene Expression for KCNS3 Potassium Channel Subunit in Parvalbumin-Containing Neurons in the Prefrontal Cortex in Schizophrenia.
- Author
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Georgiev, Danko, Arion, Dominique, Enwright, John F., Mitsuru Kikuchi, Yoshio Minabe, Corradi, John P., Lewis, David A., and Takanori Hashimoto
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SCHIZOPHRENIA ,POTASSIUM channels ,PARVALBUMINS ,PREFRONTAL cortex ,NEURONS - Abstract
Objective: In schizophrenia, alterations in markers of cortical GABA neurotransmission are prominent in parvalbumin-containing neurons. Parvalbumin neurons selectively express KCNS3, the gene encoding the Kv9.3 potassium channel α-subunit. Kv9.3 subunits are present in voltage-gated potassium channels that contribute to the precise detection of coincident excitatory synaptic inputs to parvalbumin neurons. This distinctive feature of parvalbumin neurons appears important for the synchronization of cortical neural networks in γ-oscillations. Because impaired prefrontal cortical γ-oscillations are thought to underlie the cognitive impairments in schizophrenia, the authors investigated whether KCNS3 mRNA levels are altered in the prefrontal cortex of schizophrenia subjects. Method: KCNS3 mRNA expression was evaluated by in situ hybridization in 22 matched pairs of schizophrenia and comparison subjects and by microarray analyses of pooled samples of individually dissected neurons that were labeled with Vicia villosa agglutinin (VVA), a parvalbumin neuron-selective marker, in a separate cohort of 14 pairs. Effects of chronic antipsychotic treatments on KCNS3 expression were tested in the prefrontal cortex of antipsychotic-exposed monkeys. Results: By in situ hybridization, KCNS3 mRNA levels were 23% lower in schizophrenia subjects. At the cellular level, both KCNS3 mRNA-expressing neuron density and KCNS3 mRNA level per neuron were significantly lower. By microarray, KCNS3 mRNA levels were lower by 40% in VVA-labeled neurons from schizophrenia subjects. KCNS3 mRNA levels were not altered in antipsychotic-exposed monkeys. Conclusions: These findings reveal lower KCNS3 expression in prefrontal cortical parvalbumin neurons in schizophrenia, providing a molecular basis for compromised detection of coincident synaptic inputs to parvalbumin neurons that could contribute to altered γ-oscillations and impaired cognition in schizophrenia. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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253. Atypical brain lateralisation in the auditory cortex and language performance in 3- to 7-year-old children with high-functioning autism spectrum disorder: a child-customised magnetoencephalography (MEG) study.
- Author
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Yuko Yoshimura, Mitsuru Kikuchi, Kiyomi Shitamichi, Sanae Ueno, Toshio Munesue, Yasuki Ono, Tsunehisa Tsubokawa, Yasuhiro Haruta, Manabu Oi, Yo Niida, Remijn, Gerard B., Tsutomu Takahashi, Michio Suzuki, Haruhiro Higashida, and Yoshio Minabe
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MAGNETOENCEPHALOGRAPHY ,AUDITORY evoked response ,MAGNETIC fields ,AUTISM spectrum disorders in children ,JUVENILE diseases ,LANGUAGE ability testing ,MULTIPLE regression analysis - Abstract
Background Magnetoencephalography (MEG) is used to measure the auditory evoked magnetic field (AEF), which reflects language-related performance. In young children, however, the simultaneous quantification of the bilateral auditory-evoked response during binaural hearing is difficult using conventional adult-sized MEG systems. Recently, a child-customised MEG device has facilitated the acquisition of bi-hemispheric recordings, even in young children. Using the child-customised MEG device, we previously reported that language-related performance was reflected in the strength of the early component (P50m) of the auditory evoked magnetic field (AEF) in typically developing (TD) young children (2 to 5 years old) [Eur J Neurosci 2012, 35:644-650]. The aim of this study was to investigate how this neurophysiological index in each hemisphere is correlated with language performance in autism spectrum disorder (ASD) and TD children. Methods We used magnetoencephalography (MEG) to measure the auditory evoked magnetic field (AEF), which reflects language-related performance. We investigated the P50m that is evoked by voice stimuli (/ne/) bilaterally in 33 young children (3 to 7 years old) with ASD and in 30 young children who were typically developing (TD). The children were matched according to their age (in months) and gender. Most of the children with ASD were highfunctioning subjects. Results The results showed that the children with ASD exhibited significantly less leftward lateralisation in their P50m intensity compared with the TD children. Furthermore, the results of a multiple regression analysis indicated that a shorter P50m latency in both hemispheres was specifically correlated with higher language-related performance in the TD children, whereas this latency was not correlated with non-verbal cognitive performance or chronological age. The children with ASD did not show any correlation between P50m latency and language-related performance; instead, increasing chronological age was a significant predictor of shorter P50m latency in the right hemisphere. Conclusions Using a child-customised MEG device, we studied the P50m component that was evoked through binaural human voice stimuli in young ASD and TD children to examine differences in auditory cortex function that are associated with language development. Our results suggest that there is atypical brain function in the auditory cortex in young children with ASD, regardless of language development. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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254. Functional characterization of 5-HT3-like receptors in die rat medial prefrontal cortex: biochemical and electrophysiological studies
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Charles R. Ashby, Emmeline Edwards, Rex Y. Wang, and Yoshio Minabe
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Pharmacology ,Electrophysiology ,business.industry ,Medicine ,business ,Prefrontal cortex ,Receptor ,Neuroscience - Published
- 1990
255. Receptor opermed Ca2+ influx: Upmodulaiion of Ca2+ influx evoked by bradykinin and inositol lelrakisphosphates in rus- transformed NIH/3T3 fibroblasts
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Harnhirn Higashida, Yoshinori Nozawa, Masato Hirata, Minako Hashii, and Yoshio Minabe
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Pharmacology ,medicine.medical_specialty ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Internal medicine ,medicine ,Ca2 influx ,Bradykinin ,Inositol ,Receptor - Published
- 1995
256. In vitro1H NMR spectroscopy shows an increase inN-acetylaspartylglutamate and glutamine content in the hippocampus of amygdaloid-kindled rats.
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Yukihiko Shirayama, Seizo Takahashi, Yoshio Minabe, and Takashi Ogino
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METABOLISM ,AMINO acids ,HIPPOCAMPUS (Brain) ,AMYGDALOID body ,ACETIC acid ,GABA - Abstract
We examined energy metabolism and amino acid content in the hippocampus of amygdaloid-kindled rats using
1 H NMR spectroscopy. Three weeks after the last stage 5 seizure, kindled rats were killed by microwave irradiation. The hippocampus was dissected out and subjected to MeOH/CHCl3 extraction. All1 H spectra were analyzed to quantify absolute concentrations using a non-linear least squares method, combined with a prior knowledge of chemical shifts. Saturation effects were compensated for by the T1 measurement of each component. Levels of energy metabolism-related compounds, phosphocreatine, creatine, glucose and succinate were the same in both kindled rats and sham controls. Lactate concentration had a tendency to increase, although this was not statistically significant. When compared with sham controls, levels of aspartate, glutamate, glycine and glutamine, as well as GABA and inositol, were increased in the ipsilateral but not the contralateral hippocampus. In contrast, levels of taurine, alanine and threonine were unchanged. Finally,N-acetylaspartylglutamate content was elevated, whereasN-acetyl-l-aspartate content was unaltered in the ipsilateral hippocampus of kindled animals. Our results suggest that amygdala kindling may affects amino acid metabolism, but not energy metabolism. [ABSTRACT FROM AUTHOR]- Published
- 2005
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257. Effect of the acute and chronic administration of the selective 5-HT6 receptor antagonist SB-271046 on the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study.
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Yoshio Minabe, Yukihiko Shirayama, Kenji Hashimoto, Carol Routledge, Jim J. Hagan, and Charles R. Ashby
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DOPAMINE , *NEURONS , *NERVOUS system , *SUBSTANTIA nigra , *MESENCEPHALON , *RATS , *ANTIPSYCHOTIC agents - Abstract
This study examined the effect of the acute and repeated per os (p.o.) administration of the selective 5-HT6 receptor antagonist SB-271046, on the number, as well as the firing pattern of spontaneously active dopamine (DA) neurons in the rat substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in anesthetized male Sprague-Dawley rats. This was accomplished using the technique of extracellular in vivo electrophysiology. A single p.o. administration of either 1, 3, or 10 mg/kg of SB-271046 did not significantly alter the number of spontaneously active SNC DA neurons per stereotaxic electrode tract compared to vehicle-treated animals. The acute administration of either 1 or 3 mg/kg of SB-271046 did not significantly alter the number of spontaneously active VTA DA neurons. In contrast, a significant decrease in the number of spontaneously active VTA DA neurons was observed after a single administration of 10 mg/kg of SB-271046 compared to vehicle-treated animals. The acute p.o. administration of SB-271046 significantly altered the firing pattern parameters of all (bursting + nonbursting DA neurons) DA neurons, particularly those in the VTA, compared to vehicle-treated animals. The repeated p.o. administration (once per day for 21 days) of 1, 3, or 10 mg/kg of SB-271046 did not significantly alter the number of spontaneously active VTA DA neurons compared to vehicle-treated animals. The repeated administration of 3 or 10 mg/kg of SB-271046 significantly increased the number of spontaneously active SNC DA neurons compared to vehicle controls. Overall, the repeated administration of SB-271046 had relatively little effect on the firing pattern of midbrain DA neurons. The results obtained following the chronic administration of SB-271046 show that this compound has a profile different from that of typical or atypical antipsychotic drugs in this model. Clinical studies are required to understand what role 5-HT6 receptor blockade might eventually play in the treatment of schizophrenia. Synapse 52:2028, 2004. © 2004 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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258. Effect of the acute and chronic administration of the putative atypical antipsychotic drug Y-931 (8-fluoro-12- (4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3b][1,5] benzodiazepine maleate) on spontaneously active rat midbrain dopamine neurons: An in vivo electrophysiological study
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Yoshio Minabe, Kenji Hashimoto, Yukihiko Shirayama, and Charles R. Ashby
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ANTIPSYCHOTIC agents , *DOPAMINE , *NEUROTRANSMITTERS , *LABORATORY rats , *MESENCEPHALON - Abstract
This study examined the effect of the p.o. administration of the putative atypical antipsychotic drug Y-931 (8-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3b][1,5] benzodiazepine maleate) on the activity of spontaneously active dopamine (DA) neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNC) in anesthetized male Sprague-Dawley rats. This was accomplished using in vivo electrophysiology. The acute p.o. administration of Y-931 did not significantly alter the number of spontaneously active SNC DA neurons compared to vehicle-treated animals. A single p.o. administration of 3 and 10 mg/kg of Y-931 significantly increased and decreased, respectively, the number of spontaneously active VTA DA neurons compared to vehicle-treated animals. The acute administration of 3 mg/kg of Y-931 significantly altered the firing pattern parameters for all spontaneously active SNC DA. The 3 and 10 mg/kg doses of Y-931 significantly increased the degree of bursting and irregular activity of spontaneously active VTA and SNC DA neurons firing in a bursting pattern. The repeated p.o. administration (21 days) of 1, 3, or 10 mg/kg of Y-931 significantly decreased the number of spontaneously active VTA DA neurons but had no significant effect on SNC DA neurons compared to vehicle-treated animals. The repeated administration of Y-931 did not significantly alter the firing pattern of all spontaneously active SNC or VTA DA neurons. Our findings indicate that the acute and chronic administration of Y-931 significantly alters the activity of midbrain DA neurons in rats and the electrophysiological profile of chronic Y-931 resembles that of atypical antipsychotic agents. Synapse 51:1926, 2004. © 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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259. Augmentation of milnacipran by risperidone in treatment for major depression.
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Kunihiko Tani, Nori Takei, Masayoshi Kawai, Katsuaki Suzuki, Yoshimoto Sekine, Takao Toyoda, Yoshio Minabe, and Norio Mori
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- 2004
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260. Acute and chronic administration of the selective 5-HT1A receptor antagonist WAY-405 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study.
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Yoshio Minabe, Lee Schechter, Kenji Hashimoto, Yuhiko Shirayama, and Charles R. Ashby
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SEROTONIN antagonists , *MESENCEPHALON , *DOPAMINERGIC neurons , *LABORATORY rats , *ELECTROPHYSIOLOGY , *APOMORPHINE - Abstract
In this study, we examined the effect of the acute and chronic administration of WAY-405, a selective 5-HT1A receptor antagonist, on the number and firing pattern of spontaneously active substantia nigra pars compacta (A9) and ventral tegmental area (A10) dopamine (DA) neurons in anesthetized rats. This was accomplished using in vivo, extracellular single unit recording. The i.v. administration of WAY-405 (5640 μg/kg) did not significantly alter the basal firing rate or pattern of spontaneously active A9 and A10 DA neurons. A single injection of 10 μg/kg of WAY-405 decreased the number of spontaneously active A10 DA neurons and the 100 μg/kg dose significantly decreased the number of spontaneously active A9 and A10 DA neurons compared to vehicle-treated animals. A single injection of 1, 10, or 100 μg/kg of WAY-405 significantly decreased the degree of bursting of A10 DA neurons. In contrast, 1 μg/kg i.p. of WAY-405 significantly increased the percent of A9 DA neurons exhibiting a bursting pattern. The repeated administration of 10 or 100 μg/kg i.p. of WAY-405 (21 days) significantly decreased the number of spontaneously active DA neurons in both the A9 and A10 compared to vehicle-treated animals and this decrease was not reversed by i.v. (+)-apomorphine. The repeated administration of WAY-405 significantly altered the firing pattern of DA neurons, particularly those in the A10 area. Overall, these results indicate that the antagonism of the 5-HT1A receptor significantly alters the activity of midbrain DA neurons in anesthetized rats. Synapse 50:181190, 2003. © 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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261. Effect of photic and thiosemicarbazide activation in the lateral geniculate kindled cat
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Kazunori Yoshida, Yuji Wada, Nariyoshi Yamaguchi, Hiroshi Okuda, and Yoshio Minabe
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Neurology ,business.industry ,Geniculate ,Medicine ,Photic zone ,Neurology (clinical) ,Anatomy ,business ,Neuroscience - Published
- 1986
262. Lateral geniculate kindling and long-lasting photosensitivity in cats
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Yuji Wada, Kazunori Yoshida, Yoshio Minabe, Hiroshi Okuda, Nariyoshi Yamaguchi, and Itsuki Jibiki
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Male ,Time Factors ,Photic Stimulation ,Stimulation ,Amygdala ,Developmental Neuroscience ,Seizures ,Geniculate ,Convulsion ,Kindling, Neurologic ,Animals ,Medicine ,Pentylenetetrazol ,CATS ,Kindling ,business.industry ,Geniculate Bodies ,Electroencephalography ,medicine.anatomical_structure ,Neurology ,Cats ,Female ,Disease Susceptibility ,medicine.symptom ,business ,Neuroscience ,medicine.drug - Abstract
The kindling response of the lateral geniculate body (GL) was compared with that of the amygdala, using cats. Daily electrical stimulation in the GL group led to the generalized tonic-clonic convulsion in most subjects and the resulting state of seizure susceptibility was long-lasting, as in the amygdala group. The kindling response of the GL differed from that of the amygdala in some respects, i.e., rapid kindling, short latency for seizure generalization, a different pattern of behavioral seizure development, and seizure regression during the course of kindling. The effects of photic stimulation with pentylenetetrazol administration were also examined before and after kindling in both groups. This study revealed that the photically induced myoclonus, at times proceeding to the generalized tonic-clonic convulsion, was provoked repeatedly as a result of GL kindling, whereas none of the amygdala-kindled cats showed such marked photosensitivity. These photically induced seizures were invariably observed for at least 4 weeks after GL kindling. Our results suggest that a neural mechanism participating in GL kindling is different from that in amygdala kindling, and that there might be cross-sensitization between seizure susceptibility resulting from GL kindling and photosensitivity.
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- 1986
263. Effects of chronic lithium treatment on limbic seizure generation in the cat
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Masayoshi Kurachi, Kenji Emori, and Yoshio Minabe
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Male ,Lithium (medication) ,Hippocampus ,Lithium ,Epilepsy ,Limbic system ,Seizures ,Oral administration ,Kindling, Neurologic ,Limbic System ,medicine ,Animals ,Pharmacology ,Seizure threshold ,Kindling ,business.industry ,Electroencephalography ,Limbic lobe ,medicine.disease ,Electric Stimulation ,medicine.anatomical_structure ,Anesthesia ,Cats ,Female ,business ,medicine.drug - Abstract
The effect of chronic lithium administration (2.2-8.7 mEq/kg/day, 17 days) to the cat on seizure initiation in the amygdala and hippocampus was assessed by the low-frequency kindling technique. Lithium 4.3 mEq/kg/day PO, producing a serum lithium level between 1.2 and 1.6 mEq/l, caused an elevation of the amygdala seizure threshold on treatment days 5-9. In contrast, the same dosage caused a transient reduction of the hippocampus seizure threshold on treatment days 13-17 and on withdrawal days 21-25. Lithium 2.2 mEq/kg/day PO caused no significant effect on the parameters of the two types of seizure. Lithium 8.7 mEq/kg/day PO caused severe behavioral changes and did not permit chronic treatment. These results indicate that the effect of chronic lithium treatment on limbic seizures is dependent on the location of epileptic focus.
- Published
- 1988
264. Acute Effect of Anticonvulsants on Amygdaloid Kindled Seizures Induced with Low-Frequency Stimulations
- Author
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Masayoshi Kurachi, Yasuyuki Tanii, and Yoshio Minabe
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Male ,Phenytoin ,medicine.medical_treatment ,Pharmacology ,Membrane Potentials ,Epilepsy ,Convulsion ,Kindling, Neurologic ,medicine ,Animals ,Valproic Acid ,Diazepam ,business.industry ,Brain ,Electroencephalography ,Carbamazepine ,Amygdala ,medicine.disease ,Ethosuximide ,Anticonvulsant ,Neurology ,Phenobarbital ,Anesthesia ,Cats ,Anticonvulsants ,Female ,Neurology (clinical) ,medicine.symptom ,business ,medicine.drug - Abstract
Summary: : Acute effects of several antiepileptic drugs on low-frequency amygdaloid-kindled seizures were assessed. The number of stimulating pulses required for the provocation of epileptic afterdischarge (pulse-number threshold, PNT) was used as an indicator for the seizure-generating threshold. The duration of epileptic afterdischarge (AD duration) was used as an indicator for the severity of the induced seizures. Phenytoin (PHT) and carbamazepine (CBZ) reduced AD duration more than did elevating PNT. Conversely, phenobarbital (PB) and diazepam (DZP) elevated PNT more than did reducing AD duration. Weak effects on the two indicators, valproic acid (VPA) and ethosuximide (ESM), were observed. Low-frequency kindling may be a useful experimental model of epilepsy in drug-assessments.
- Published
- 1987
265. Saving-effect of stimulating pulses at low-frequency amygdaloid kindling in cats
- Author
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Manabu Tsutsumi, Yasuyuki Tanii, Yoshio Minabe, Youichi Kadono, and Ichiro Nakamura
- Subjects
Provocation test ,Action Potentials ,Globus Pallidus ,Amygdala ,Hippocampus ,Amygdaloid nucleus ,Parietal Lobe ,Kindling, Neurologic ,Medicine ,Animals ,Amygdaloid kindling ,Molecular Biology ,Low frequency stimulation ,CATS ,business.industry ,Kindling ,General Neuroscience ,Generalized convulsion ,Electric Stimulation ,Frontal Lobe ,medicine.anatomical_structure ,Cats ,Neurology (clinical) ,business ,Neuroscience ,Developmental Biology - Abstract
Cats were stimulated in the lateral amygdala with low-frequency square-wave pulses. All subjects were kindled until generalized convulsion occurred. During the kindling process, a prolongation of the interpulse interval and a reduction of the number of pulses required for the provocation of afterdischarges were observed. We refer to this phenomenon as the ‘saving-effect’ of stimulating pulses to provoke afterdischarges.
- Published
- 1986
266. Effects of chronic haloperidol treatment on amygdaloid seizure generation in cats
- Author
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Masayoshi Kurachi, Yoshio Minabe, and Manabu Tsutsumi
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Male ,medicine.medical_treatment ,Neurochemical ,Seizures ,Convulsion ,Kindling, Neurologic ,Haloperidol ,Animals ,Medicine ,Antipsychotic ,Pharmacology ,CATS ,Seizure threshold ,business.industry ,Kindling ,Electroencephalography ,Amygdala ,Electric Stimulation ,Electrodes, Implanted ,Anesthesia ,Toxicity ,Cats ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
We evaluated the effect of chronic haloperidol treatment (0.5-2 mg/kg/day, 21 day) on amygdala-generating seizures using a kindling procedure induced by low frequency electrical stimulations. The number of stimulating pulses required for triggering of epileptic afterdischarge (pulse-number threshold; PNT) is the indicator of the seizure generating threshold. A PNT decrease occurred, followed by a PNT increase toward the pre-treatment level during high-dose, chronic haloperidol treatment. A PNT increase occurred, followed by a PNT decrease toward the pre-treatment level during the withdrawal period after the high-dose treatment. A decrease of the triggered seizure duration occurred during the high-dose treatment. These results indicate that a transient decrease of seizure generating threshold occurs during chronic haloperidol treatment, and withdrawal of the drug is followed by what appears to be a rebound phenomenon. We suggest that this effect might be related to the antipsychotic potency and associated neurochemical changes known to be caused by chronic haloperidol treatment.
- Published
- 1988
267. Serial changes of the susceptibility of epileptogenic focus during hippocampal kindling induced with low-frequency electrical stimulation in cats
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Yasuyuki Tanii, Yohichi Kadono, Masayoshi Kurachi, Manabu Tsutsumi, and Yoshio Minabe
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Epileptogenic focus ,Dorsal hippocampus ,CATS ,Epilepsy ,Time Factors ,Kindling ,Chemistry ,General Neuroscience ,Provocation test ,Hippocampus ,Brain ,Stimulation ,Hippocampal formation ,Electric Stimulation ,Membrane Potentials ,Cats ,Kindling, Neurologic ,Animals ,Neurology (clinical) ,Molecular Biology ,Neuroscience ,Developmental Biology - Abstract
Cats were stimulated in the dorsal hippocampus with low-frequency square wave pulses. All subjects were kindled until generalized convulsion occured. In the early stage of the kindling process, an increase in the interpulse interval and a decrease in the number of stimulating pulses required for the provocation of epileptic afterdischarge were observed, but in the late stage a decrease in the former and an increase in the latter were observed. It appears from these data that completion of hippocampal kindling is accompanied by a decrease in excitability at the site of stimulation subsequent to an increase in the same.
- Published
- 1987
268. An evidence of 'post-seizure excitation' in feline-kindled seizures
- Author
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Masayoshi Kurachi, Yoshio Minabe, and Kenji Emori
- Subjects
Male ,CATS ,Seizure threshold ,Kindling ,business.industry ,General Neuroscience ,Hippocampus ,Action Potentials ,Amygdala ,Seizures ,Anesthesia ,Cats ,Kindling, Neurologic ,Medicine ,Animals ,Female ,Neurology (clinical) ,business ,Molecular Biology ,Developmental Biology ,Low frequency stimulation - Abstract
We assessed the post-seizure effects on the seizure threshold and the seizure duration using low-frequency kindling technique. The number of stimulating pulses required for a triggering of epileptic afterdischarge (pulse-number threshold; PNT) was used for the indicator of seizure threshold. PNT increased significantly at 2 and 4 h inter-stimulation intervals, whereas it decreased significantly with an increase of seizure duration at 16 and 24 h intervals. It appears from these data that a post-seizure excitation occurs after a post-seizure inhibition.
- Published
- 1989
269. Low-frequency kindling as a new experimental model of epilepsy
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Ichiro Nakamura, Yoshio Minabe, Yasuyuki Tanii, Yohichi Kadono, and Manabu Tsutsumi
- Subjects
Male ,CATS ,Epilepsy ,Kindling ,Experimental model ,Provocation test ,Stimulation ,medicine.disease ,Amygdala ,Electric Stimulation ,Electrophysiology ,medicine.anatomical_structure ,Developmental Neuroscience ,Neurology ,Anesthesia ,medicine ,Cats ,Kindling, Neurologic ,Animals ,Phenobarbital ,Female ,Psychology ,medicine.drug - Abstract
Ten cats were stimulated twice a day in the lateral amygdala with low-frequency stimulation of about 3 Hz until generalized convulsion occurred. After the completion of kindling, the longest interpulse interval required for provocation of generalized convulsion (pulse-interval threshold) was determined in each subject. The pulse-interval threshold was 1300 ms in five cats, and 900 ms in five other cats. Then the stability of pulse-interval threshold and of the number of stimulating pulses required for provocation of afterdischarge when the stimulation was delivered with the pulse-interval threshold (pulse-number threshold) was tested. The pulse-interval threshold, pulse-number threshold, and duration of afterdischarge in each stimulation did not change statistically at the interstimulation interval from 24 h to 7 days. Phenobarbital and diphenylhydantoin elevated the pulse-number threshold significantly. We propose that low-frequency kindling is a valuable experimental model of epilepsy in assessing simply and precisely the susceptibility of the epileptic focus itself and the severity of epileptic seizures.
- Published
- 1986
270. Effects of chronic treatment of methamphetamine and imipramine on amygdaloid seizure's generation
- Author
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Masayoshi Kurachi, Kenji Emori, and Yoshio Minabe
- Subjects
Male ,Imipramine ,Pharmacology ,Methamphetamine ,Neurochemical ,Oral administration ,Convulsion ,medicine ,Kindling, Neurologic ,Animals ,Evoked Potentials ,Seizure threshold ,Dose-Response Relationship, Drug ,Kindling ,business.industry ,General Neuroscience ,Electroencephalography ,General Medicine ,Amygdala ,Psychiatry and Mental health ,Neurology ,Toxicity ,Cats ,Female ,Neurology (clinical) ,medicine.symptom ,business ,medicine.drug - Abstract
We assessed the effects of chronic treatment of methamphetamine (1–2 mg/kg/day, i.p., 17 days) and imipramine (2–8 mg/kg/day, P.o., 17 days) on amygdala-generating seizures using the kindling method induced by low-frequency electrical stimulations. The number of stimulating pulses required for the triggering of epileptic after-discharge (pulse-number threshold: PNT) is the indicator of seizure generating threshold. A PNT elevation followed by its reduction occurred, compared to the pretreatment level, during a 2 mg/kg/day chronic methamphetamine treatment. A reduction in the PNT and triggered afterdischarge durations occurred during a chronic imipramine treatment. These results indicate that both methamphetamine and imipramine reduced the seizure generating threshold by repeated applications. It is suggested that this finding might be related to the psychoactive potency and associated neurochemical changes which are known to be caused by these drugs.
- Published
- 1988
271. Acute effect of some psychotropic drugs on low-frequency amygdaloid kindled seizures
- Author
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Yasuyuki Tanii, Yoshio Minabe, and Masayoshi Kurachi
- Subjects
Male ,Imipramine ,Reserpine ,Stimulation ,Pharmacology ,Methamphetamine ,Epilepsy ,medicine ,Haloperidol ,Kindling, Neurologic ,Animals ,Evoked Potentials ,Biological Psychiatry ,Psychotropic Drugs ,biology ,Dose-Response Relationship, Drug ,business.industry ,Fissipedia ,Electroencephalography ,medicine.disease ,biology.organism_classification ,Amygdala ,Atropine ,Cats ,Female ,business ,medicine.drug - Abstract
We assessed the acute effects of some psychotropic drugs on amygdaloid-kindled seizures produced by low-frequency stimulation. We used the number of stimulating pulses required for the induction of epileptic afterdischarge (pulse-number threshold, PNT) as an indicator for the seizure-generating threshold, and the duration of the epileptic afterdischarge (AD duration, ADD) as an indicator for the duration of the induced seizures. Methamphetamine and atropine elevated the PNT and reduced the ADD. Haloperidol reduced the PNT at all tested doses and reduced the ADD at high dosage. Imipramine elevated the PNT at low doses and reduced the PNT at high dosage. Imipramine also reduced the ADD. Reserpine at high dose elevated the PNT without affecting the ADD.
- Published
- 1987
272. Lack of neuroprotective effect of σ receptor ligands in the neurotoxicity of p-chloroamphetamine in rat brain
- Author
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Natsuko Narita, Kenji Hashimoto, Masaomi Iyo, Yoshio Minabe, and Kosuke Yamazaki
- Published
- 1995
- Full Text
- View/download PDF
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