Back to Search
Start Over
Acute effect of some psychotropic drugs on low-frequency amygdaloid kindled seizures
- Source :
- Biological psychiatry. 22(12)
- Publication Year :
- 1987
-
Abstract
- We assessed the acute effects of some psychotropic drugs on amygdaloid-kindled seizures produced by low-frequency stimulation. We used the number of stimulating pulses required for the induction of epileptic afterdischarge (pulse-number threshold, PNT) as an indicator for the seizure-generating threshold, and the duration of the epileptic afterdischarge (AD duration, ADD) as an indicator for the duration of the induced seizures. Methamphetamine and atropine elevated the PNT and reduced the ADD. Haloperidol reduced the PNT at all tested doses and reduced the ADD at high dosage. Imipramine elevated the PNT at low doses and reduced the PNT at high dosage. Imipramine also reduced the ADD. Reserpine at high dose elevated the PNT without affecting the ADD.
- Subjects :
- Male
Imipramine
Reserpine
Stimulation
Pharmacology
Methamphetamine
Epilepsy
medicine
Haloperidol
Kindling, Neurologic
Animals
Evoked Potentials
Biological Psychiatry
Psychotropic Drugs
biology
Dose-Response Relationship, Drug
business.industry
Fissipedia
Electroencephalography
medicine.disease
biology.organism_classification
Amygdala
Atropine
Cats
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 00063223
- Volume :
- 22
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Biological psychiatry
- Accession number :
- edsair.doi.dedup.....49635ba2623b126cda9d32f4497d73cb