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252. Docosahexanoic Acid Plus Vitamin D Treatment Improves Features of NAFLD in Children with Serum Vitamin D Deficiency: Results from a Single Centre Trial

Author

Della Corte, Claudia, primary, Carpino, Guido, additional, De Vito, Rita, additional, De Stefanis, Cristiano, additional, Alisi, Anna, additional, Cianfarani, Stefano, additional, Overi, Diletta, additional, Mosca, Antonella, additional, Stronati, Laura, additional, Cucchiara, Salvatore, additional, Raponi, Massimiliano, additional, Gaudio, Eugenio, additional, Byrne, Christopher D., additional, and Nobili, Valerio, additional

Published
2016
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254. OSAS-Related Inflammatory Mechanisms of Liver Injury in Nonalcoholic Fatty Liver Disease

Author

Paschetta, Elena, Belci, Paola, Alisi, Anna, Liccardo, Daniela, Cutrera, Renato, Musso, Giovanni, and Nobili, Valerio

Subjects
Article Subject
Abstract

Obstructive sleep apnoea syndrome (OSAS) is a common sleep disorder, affecting over 4% of the general population, and is associated with metabolic syndrome and cardiovascular disease, independent of obesity and traditional risk factors. OSAS has been recently connected to nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease in the world, which can be found in 30% of the general adult population. Several studies suggest that the chronic intermittent hypoxia (CIH) of OSAS patients may per se trigger liver injury, inflammation, and fibrogenesis, promoting NAFLD development and the progression from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. In NAFLD patients, liver disease may be caused by hypoxia both indirectly by promoting inflammation and insulin resistance and directly by enhancing proinflammatory cytokine production and metabolic dysregulation in liver cells. In this review, we focus on molecular mechanisms linking OSAS to NAFLD, including hypoxia inducible factor (HIF), nuclear factor kappa B (NF-κB), YKL-40, unfolded protein response, and hypoxic adipose tissue inflammation, which all could provide novel potential therapeutic approaches for the management of NAFLD patients with OSAS.

Published
2015
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255. Atherogenic Dyslipidemia and Cardiovascular Risk Factors in Obese Children

Author

D’Adamo, Ebe, Guardamagna, Ornella, Chiarelli, Francesco, Bartuli, Andrea, Liccardo, Daniela, Ferrari, Federica, and Nobili, Valerio

Subjects
Article Subject
Abstract

Childhood obesity when associated with serum lipoprotein changes triggers atherosclerosis. Evidences suggest that the atherosclerotic process begins in childhood and that the extent of early atherosclerosis of the aorta and coronary arteries can be associated with lipoprotein levels and obesity. Furthermore, many studies in childhood demonstrate an important relationship between parameters of insulin sensitivity, body fat distribution, and the development of lipid abnormalities. This review focuses on the most recent findings on the relationship between obesity, dyslipidemia, and cardiovascular risk in children.

Published
2015
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256. Growth failure in Crohn's disease children: may the first treatment have a role?

Author

Capriati, Teresa, Bizzarri, Carla, Dilillo, Anna, Nobili, Valerio, Oliva, Salvatore, and Diamanti, Antonella

Subjects
JUVENILE diseases, STUNTED growth, GROWTH of children, CROHN'S disease
Abstract

Introduction: Growth failure in children is a frequent feature of childhood-onset Crohn's disease (CD), and stunting can persist into adulthood. Growth is an important outcome by which to judge the effectiveness of therapies in children; currently available studies in CD children have focused on the short-term impact of treatments on growth, and there are limited data regarding the long-term effects of treatments upon growth. Areas covered: We designed the present article to review whether the first treatment performed in newly diagnosed CD children may have a role on the future growth course. We conducted a systematic literature search to identify relevant studies published on the PubMed database from January 2002 up to now. We found only six surveys that documented mid-term growth course in newly diagnosed CD patients. Expert commentary: In the last years there have been relevant advances in the clinical management of CD children; however, there is a lack of knowledge about the best strategy to reverse growth failure. Children treated with enteral nutrition have appropriate height and weight gain but do not reverse the growth course. Further surveys are required to better explore not only clinical outcomes but also long-term growth course following each therapeutic strategy. [ABSTRACT FROM AUTHOR]

Published
2019
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257. Hepatitis E in Children: A Position Paper by the ESPGHAN Hepatology Committee

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Fischler, Björn, Baumann, Ulrich, Dezsofi, Antal, Hadzic, Nedim, Hierro, Loreto, Jahnel, Jörg, McLin, Valérie, Nobili, Valerio, Smets, Françoise, Verkade, Henkjan, Debray, Dominique, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Fischler, Björn, Baumann, Ulrich, Dezsofi, Antal, Hadzic, Nedim, Hierro, Loreto, Jahnel, Jörg, McLin, Valérie, Nobili, Valerio, Smets, Françoise, Verkade, Henkjan, and Debray, Dominique

Abstract

BACKGROUND: Hepatitis E virus (HEV) is endemic in large parts of the developing world. Waterborne transmission of genotypes 1 or 2 commonly causes acute hepatitis, which is usually self limited in healthy individuals. In addition, acute HEV infections also occur outside endemic areas, mostly related to foodborne transmission of HEV genotype 3. A growing number of publications in the last decade have reported chronic infection progressing to cirrhosis in immunosuppressed patients. It has also been suggested that HEV transmission may occur via contaminated blood products. This publication aims to provide recommendations for diagnosis, prevention and treatment of HEV infection, particularly in children after solid organ transplantation (SOT). METHODS: A systematic PubMed literature search on HEV infection from 1990 to January 2016 was performed focusing on paediatric studies. The existing body of evidence was reviewed and recommendations were agreed upon following discussion and unanimous agreement by all members of the ESPGHAN Hepatology Committee during a consensus meeting in January 2016. In the absence of randomized controlled studies these recommendations were considered to be expert opinions.

Published
2016

258. A 'systems medicine' approach to the study of non-alcoholic fatty liver disease

Author

Petta, Salvatore, Valenti, Luca, Bugianesi, Elisabetta, Targher, Giovanni, Bellentani, Stefano, Bonino, Ferruccio, Fargion, Silvia, Vanni, Ester, Ferrannini, Ele, Loguercio, Carmela, Lonardo, Amedeo, Marra, Fabio, Mancini, Marcello, Miele, Luca, Nobili, Valerio, Baroni, Gianluca Svegliati, Alessandro, Federico, Ballestri, Stefano, Brunetto, Maurizia Rossana, Coco, Barbara, Grieco, Antonio, Kondili, Loreta, Nascimbeni, Fabio, Prinster, Anna, Romagnoli, Dante, Taddei, Stefano, Vella, Stefano, Miele, Luca (ORCID:0000-0003-3464-0068), Grieco, Antonio (ORCID:0000-0002-0544-8993), Petta, Salvatore, Valenti, Luca, Bugianesi, Elisabetta, Targher, Giovanni, Bellentani, Stefano, Bonino, Ferruccio, Fargion, Silvia, Vanni, Ester, Ferrannini, Ele, Loguercio, Carmela, Lonardo, Amedeo, Marra, Fabio, Mancini, Marcello, Miele, Luca, Nobili, Valerio, Baroni, Gianluca Svegliati, Alessandro, Federico, Ballestri, Stefano, Brunetto, Maurizia Rossana, Coco, Barbara, Grieco, Antonio, Kondili, Loreta, Nascimbeni, Fabio, Prinster, Anna, Romagnoli, Dante, Taddei, Stefano, Vella, Stefano, Miele, Luca (ORCID:0000-0003-3464-0068), and Grieco, Antonio (ORCID:0000-0002-0544-8993)

Abstract

The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g. the definition of risk, prognosis, diagnosis criteria, and new endpoints of clinical trials). Based on this premise and in light of recent findings, the complex mechanisms involved in the pathology of fatty liver and their impact on the short- and long-term clinical outcomes of cardiovascular, metabolic liver diseases associated with steatosis are presented in this review using a new "systems medicine" approach. A new data set is proposed for studying the impairments of different physiological systems that have an impact on fatty liver in different subsets of subjects and patients.

Published
2016

259. Macrophage accumulation and fibrosis in adipose tissue is linked to liver damage and metabolic risk in obese children

Author

Walker, Ryan W, Allayee, Hooman, Inserra, Alessandro, Fruhwirth, Rodolfo, Alisi, Anna, Devito, Rita, Carey, Magalie E, Sinatra, Frank, Goran, Michael I, and Nobili, Valerio

Subjects
Blood Glucose, Liver Cirrhosis, Male, Adolescent, Intra-Abdominal Fat, Article, Body Mass Index, Risk Factors, Humans, Insulin, Aspartate Aminotransferases, Obesity, Prospective Studies, Child, Adiposity, Interleukin-6, Tumor Necrosis Factor-alpha, Macrophages, Body Weight, Alanine Transaminase, Fasting, Body Height, Subcutaneous Fat, Abdominal, C-Reactive Protein, Diabetes Mellitus, Type 2, Liver, Female, Adiponectin, Biomarkers
Abstract

Obesity in childhood is associated with an inflammatory state in adipose tissue and liver, which elevates risk for diabetes and liver disease. No prior study has examined associations between pathologies occurring in adipose tissue and liver to identify elements of tissue damage associated with type 2 diabetes risk. This study sought to determine whether inflammation and fibrosis in abdominal subcutaneous adipose tissue (SAT) in obese/overweight children (BMI-z 2.3 ± 0.76) was related to the extent of observed liver disease or type 2 diabetes risk.Biopsy samples of abdominal (SAT) and liver were simultaneously collected from 33 Italian children (mean BMI 28.1 ± 5.1 kg/m(2) and mean age 11.6 ± 2.2 years) with confirmed NAFLD. Histology and immunohistochemistry were conducted on biopsies to assess inflammation and fibrosis in adipose tissue and fibrosis and inflammation in liver.Presence vs. absence of crown-like structures (CLS) in SAT was significantly related to liver fibrosis scores (1.7 ± 0.7 vs. 1.2 ± 0.7, P = 0.04) independent of BMI. SAT fibrosis was significantly correlated with a lower disposition index (r = -0.48, P = 0.006). No other adipose measures were associated with liver disease parameters.Markers of subcutaneous white adipose tissue inflammation are associated with greater extent of liver fibrosis independent of obesity and SAT fibrosis may contribute to diabetes risk through reduced insulin secretion.

Published
2014

263. Macrophage Activation in Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Correlates with Hepatic Progenitor Cell Response via Wnt3a Pathway

Author

Carpino, Guido, primary, Nobili, Valerio, additional, Renzi, Anastasia, additional, De Stefanis, Cristiano, additional, Stronati, Laura, additional, Franchitto, Antonio, additional, Alisi, Anna, additional, Onori, Paolo, additional, De Vito, Rita, additional, Alpini, Gianfranco, additional, and Gaudio, Eugenio, additional

Published
2016
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264. Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta‐omics‐based approach

Author

Del Chierico, Federica, primary, Nobili, Valerio, additional, Vernocchi, Pamela, additional, Russo, Alessandra, additional, De Stefanis, Cristiano, additional, Gnani, Daniela, additional, Furlanello, Cesare, additional, Zandonà, Alessandro, additional, Paci, Paola, additional, Capuani, Giorgio, additional, Dallapiccola, Bruno, additional, Miccheli, Alfredo, additional, Alisi, Anna, additional, and Putignani, Lorenza, additional

Published
2016
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265. The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

Author

Mancina, Rosellina Margherita, primary, Dongiovanni, Paola, additional, Petta, Salvatore, additional, Pingitore, Piero, additional, Meroni, Marica, additional, Rametta, Raffaela, additional, Borén, Jan, additional, Montalcini, Tiziana, additional, Pujia, Arturo, additional, Wiklund, Olov, additional, Hindy, George, additional, Spagnuolo, Rocco, additional, Motta, Benedetta Maria, additional, Pipitone, Rosaria Maria, additional, Craxì, Antonio, additional, Fargion, Silvia, additional, Nobili, Valerio, additional, Käkelä, Pirjo, additional, Kärjä, Vesa, additional, Männistö, Ville, additional, Pihlajamäki, Jussi, additional, Reilly, Dermot F., additional, Castro-Perez, Jose, additional, Kozlitina, Julia, additional, Valenti, Luca, additional, and Romeo, Stefano, additional

Published
2016
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269. A “systems medicine” approach to the study of non-alcoholic fatty liver disease

Author

Petta, Salvatore, primary, Valenti, Luca, additional, Bugianesi, Elisabetta, additional, Targher, Giovanni, additional, Bellentani, Stefano, additional, Bonino, Ferruccio, additional, Ferrannini, Ele, additional, Loguercio, Carmela, additional, Lonardo, Amedeo, additional, Marra, Fabio, additional, Mancini, Marcello, additional, Miele, Luca, additional, Nobili, Valerio, additional, Baroni, Gianluca Svegliati, additional, Alessandro, Federico, additional, Ballestri, Stefano, additional, Rossana Brunetto, Maurizia, additional, Coco, Barbara, additional, Grieco, Antonio, additional, Fargion, Silvia, additional, Kondili, Loreta, additional, Nascimbeni, Fabio, additional, Prinster, Anna, additional, Romagnoli, Dante, additional, Taddei, Stefano, additional, Vanni, Ester, additional, and Vella, Stefano, additional

Published
2016
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278. PCSK7gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients

Author

Dongiovanni, Paola, Meroni, Marica, Baselli, Guido, Mancina, Rosellina M., Ruscica, Massimiliano, Longo, Miriam, Rametta, Raffaela, Cespiati, Annalisa, Pelusi, Serena, Ferri, Nicola, Ranzani, Valeria, Nobili, Valerio, Pihlajamaki, Jussi, Fracanzani, Anna Ludovica, Badiali, Sara, Petta, Salvatore, Fargion, Silvia, Romeo, Stefano, Kozlitina, Julia, and Valenti, Luca

Abstract

Dyslipidemia and altered iron metabolism are typical features of nonalcoholic fatty liver disease (NAFLD). Proprotein convertase subtilisin/kexin type 7 (PCSK7) gene variation has been associated with circulating lipids and liver damage during iron overload. The aim of this study was to examine the impact of the PCSK7rs236918 variant on NAFLD-related traits in 1,801 individuals from the Liver Biopsy Cohort (LBC), 500,000 from the UK Biobank Cohort (UKBBC), and 4,580 from the Dallas Heart Study (DHS). The minor PCSK7rs236918 C allele was associated with higher triglycerides, aminotransferases, and hepatic inflammation in the LBC (P< 0.05) and with hypercholesterolemia and liver disease in the UKBBC. In the DHS, PCSK7missense variants were associated with circulating lipids. PCSK7was expressed in hepatocytes and its hepatic expression correlated with that of lipogenic genes (P< 0.05). The rs236918 C allele was associated with upregulation of a new “intra-PCSK7” long noncoding RNA predicted to interact with the protein, higher hepatic and circulating PCSK7 protein (P< 0.01), which correlated with triglycerides (P= 0.04). In HepG2 cells, PCSK7deletion reduced lipogenesis, fat accumulation, inflammation, transforming growth factor β pathway activation, and fibrogenesis. In conclusion, PCSK7gene variation is associated with dyslipidemia and more severe liver disease in high risk individuals, likely by modulating PCSK7expression/activity.

Published
2019
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279. Similarities and Differences in Allocation Policies for Pediatric Liver Transplantation Across the World

Author

Fischler, Björn, Baumann, Ulrich, D'Agostino, Daniel, D'Antiga, Lorenzo, Dezsofi, Antal, Debray, Dominique, Durmaz, Ozlem, Evans, Helen, Frauca, Esteban, Hadzic, Nedim, Jahnel, Jörg, Loveland, Jerome, McLin, Valérie, Ng, Vicky L., Nobili, Valerio, Pawlowska, Joanna, Sharif, Khalid, Smets, Francoise, Verkade, Henkjan J., Hsu, Evelyn, Horslen, Simon, and Bucuvalas, John

Abstract

We aimed to investigate national allocation policies for pediatric liver transplantation (LT). A survey was prepared by the European Society for Paediatric Gastroenterology Hepatology and Nutrition Hepatology Committee in collaboration with the North American Studies of Pediatric Liver Transplantation consortium. The survey was sent to pediatric hepatologists and transplant surgeons worldwide. National data were obtained from centrally based registries. Replies were obtained from 15 countries from 5 of the world continents. Overall donation rate varied between 9 and 35 per million inhabitants. The number of pediatric LTs was 4 to 9 per million inhabitants younger than 18 years for 13 of the 15 respondents. In children younger than 2 years mortality on the waiting list (WL) varied between 0 and 20%. In the same age group, there were large differences in the ratio of living donor LT to deceased donor LT and in the ratio of split liver segments to whole liver. These differences were associated with possible discrepancies in WL mortality. Similarities but also differences between countries were detected. The described data may be of importance when trying to reduce WL mortality in the youngest children.

Published
2019
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280. Hepatic progenitor cells as a source of adipokines and glucagon-like peptide-1 in pediatric nonalcoholic fatty liver disease

Author

Carpino, Guido, Nobili, Valerio, Onori, Paolo, Alisi, Anna, Franchitto, Antonio, De Vito, Rita, Mancinelli, Romina, Alpini, Gianfranco, Alvaro, Domenico, and Gaudio, Eugenio

Subjects
nutritional and metabolic diseases, digestive system, digestive system diseases, adiponectin, resistin, NASH, stem, progenitor
Abstract

Background & aims. nonalcoholic fatty liver disease (NAFLD) is one of the most important causes of liver-related morbidity and mortality in children. NAFLD includes a spectrum of diseases ranging from simple fatty liver to nonalcoholic steatohepatitis (NASH)1. NASH development is characterized by intricate interactions between resident and recruited cells2. The aim of our study was to evaluate the involvement of Hepatic Progenitor Cells (HPCs) in pediatric NAFLD. Methods. 20 untreated, consecutive children and adolescents with biopsy-proven NAFLD (12 NASH, 8 NO-NASH) were studied by immunohistochemistry/fluorescence. HPCs and intermediate hepatocytes were counted and correlated with steatosis, inflammation, hepatocyte ballooning, fibrosis and the NAFLD activity score (NAS). Finally, the expression of adipokines (adiponectin, resistin, GLP-1) in liver cells was assessed. Results. HPC compartment was markedly expanded in pNAFLD and especially in childrens with NASH and this was independently associated with the degree of fibrosis. NASH livers were also characterized by the appearance of intermediate hepatocytes. Adiponectin expression in HPCs of NAFLD patients appears to be down-regulated with respect to the normal liver and this was correlated with lobular inflammation and steatosis. Resistin expression increases in pNAFLD in relation with the expansion of HPCs pool and with the degree of fibrosis. GLP-1 was overexpressed in HPCs of pNAFLD patients in relation with the degree of steatosis and NAS. Conclusions. HPCs activation takes part of liver response to oxidative stress in pediatric NAFLD and is correlated with the setting of fibrosis and the progression towards NASH. Adiponectin, resistin and GLP-1 become available to liver resident cells not only through the bloodstream but, possibly, through local production by paracrine mechanisms. The intra-hepatic expression of these proteins is strongly associated with the severity of pediatric NAFLD and may have relevant implications both in diagnosis and therapy. 1. Alisi A et al. J Pediatr 2009;155:469-74 2. Gaudio E et al. Dig Liver Dis 2009;41:455-62, Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011

Published
2011

281. Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children

Author

Alisi, Anna, Panera, Nadia, Agostoni, Carlo, and Nobili, Valerio

Subjects
Article Subject, nutritional and metabolic diseases, reproductive and urinary physiology, digestive system diseases
Abstract

Intrauterine growth retardation (IUGR), the most important cause of perinatal mortality and morbidity, is defined as a foetal growth less than normal for the population, often used as synonym of small for gestational age (SGA). Studies demonstrated the relationships between metabolic syndrome (MS) and birthweight. This study suggested that, in children, adolescents, and adults born SGA, insulin resistance could lead to other metabolic disorders: type 2 diabetes (DM2), dyslipidemia, and nonalcoholic fatty liver disease (NAFLD). NAFLD may evolve to nonalcoholic steatohepatitis (NASH), and it is related to the development of MS. Lifestyle intervention, physical activity, and weight reduction represent the mainstay of NAFLD therapy. In particular, a catch-up growth reduction could decrease the risk to develop MS and NAFLD. In this paper, we outline clinical and experimental evidences of the association between IUGR, metabolic syndrome, insulin resistance, and NAFLD and discuss on a possible management to avoid the risk of MS in adulthood.

Published
2011
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283. LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease

Author

Ceccarelli, Sara, primary, Panera, Nadia, additional, Mina, Marco, additional, Gnani, Daniela, additional, De Stefanis, Cristiano, additional, Crudele, Annalisa, additional, Rychlicki, Chiara, additional, Petrini, Stefania, additional, Bruscalupi, Giovannella, additional, Agostinelli, Laura, additional, Stronati, Laura, additional, Cucchiara, Salvatore, additional, Musso, Giovanni, additional, Furlanello, Cesare, additional, Svegliati-Baroni, Gianluca, additional, Nobili, Valerio, additional, and Alisi, Anna, additional

Published
2015
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286. Statin use and non-alcoholic steatohepatitis in at risk individuals

Author

Dongiovanni, Paola, primary, Petta, Salvatore, additional, Mannisto, Ville, additional, Mancina, Rosellina Margherita, additional, Pipitone, Rosaria, additional, Karja, Vesa, additional, Maggioni, Marco, additional, Kakela, Pirjo, additional, Wiklund, Olov, additional, Mozzi, Enrico, additional, Grimaudo, Stefania, additional, Kaminska, Dorota, additional, Rametta, Raffaela, additional, Craxi, Antonio, additional, Fargion, Silvia, additional, Nobili, Valerio, additional, Romeo, Stefano, additional, Pihlajamaki, Jussi, additional, and Valenti, Luca, additional

Published
2015
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287. Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease

Author

Jahnel, Jörg, primary, Zöhrer, Evelyn, additional, Alisi, Anna, additional, Ferrari, Federica, additional, Ceccarelli, Sara, additional, De Vito, Rita, additional, Scharnagl, Hubert, additional, Stojakovic, Tatjana, additional, Fauler, Günter, additional, Trauner, Michael, additional, and Nobili, Valerio, additional

Published
2015
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291. Indications and Limitations of Bariatric Intervention in Severely Obese Children and Adolescents With and Without Nonalcoholic Steatohepatitis

Author

Nobili, Valerio, primary, Vajro, Pietro, additional, Dezsofi, Antal, additional, Fischler, Bjorn, additional, Hadzic, Nedim, additional, Jahnel, Joerg, additional, Lamireau, Thierry, additional, McKiernan, Patrick, additional, McLin, Valerie, additional, Socha, Piotr, additional, Tizzard, Sarah, additional, and Baumann, Ulrich, additional

Published
2015
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294. Liver Biopsy in Children

Author

Dezsőfi, Antal, primary, Baumann, Ulrich, additional, Dhawan, Anil, additional, Durmaz, Ozlem, additional, Fischler, Björn, additional, Hadzic, Nedim, additional, Hierro, Loreto, additional, Lacaille, Florence, additional, McLin, Valérie A., additional, Nobili, Valerio, additional, Socha, Piotr, additional, Vajro, Pietro, additional, and Knisely, Alexander S., additional

Published
2015
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295. Plasma Cathepsin D Levels: A Novel Tool to Predict Pediatric Hepatic Inflammation

Author

Walenbergh, Sofie M A, primary, Houben, Tom, additional, Hendrikx, Tim, additional, Jeurissen, Mike L J, additional, van Gorp, Patrick J, additional, Vreugdenhil, Anita C E, additional, Adriaanse, Marlou P, additional, Buurman, Wim A, additional, Hofker, Marten H, additional, Mosca, Antonella, additional, Lindsey, Patrick J, additional, Alisi, Anna, additional, Liccardo, Daniela, additional, Panera, Nadia, additional, Koek, Ger H, additional, Nobili, Valerio, additional, and Shiri-Sverdlov, Ronit, additional

Published
2015
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296. Nonalcoholic Fatty Liver Disease

Author

Nobili, Valerio, primary, Alkhouri, Naim, additional, Alisi, Anna, additional, Della Corte, Claudia, additional, Fitzpatrick, Emer, additional, Raponi, Massimiliano, additional, and Dhawan, Anil, additional

Published
2015
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298. Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

Author

Dongiovanni, Paola, primary, Petta, Salvatore, additional, Maglio, Cristina, additional, Fracanzani, Anna Ludovica, additional, Pipitone, Rosaria, additional, Mozzi, Enrico, additional, Motta, Benedetta Maria, additional, Kaminska, Dorota, additional, Rametta, Raffaela, additional, Grimaudo, Stefania, additional, Pelusi, Serena, additional, Montalcini, Tiziana, additional, Alisi, Anna, additional, Maggioni, Marco, additional, Kärjä, Vesa, additional, Borén, Jan, additional, Käkelä, Pirjo, additional, Di Marco, Vito, additional, Xing, Chao, additional, Nobili, Valerio, additional, Dallapiccola, Bruno, additional, Craxi, Antonio, additional, Pihlajamäki, Jussi, additional, Fargion, Silvia, additional, Sjöström, Lars, additional, Carlsson, Lena M., additional, Romeo, Stefano, additional, and Valenti, Luca, additional

Published
2015
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