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A 'systems medicine' approach to the study of non-alcoholic fatty liver disease

Authors :
Petta, Salvatore
Valenti, Luca
Bugianesi, Elisabetta
Targher, Giovanni
Bellentani, Stefano
Bonino, Ferruccio
Fargion, Silvia
Vanni, Ester
Ferrannini, Ele
Loguercio, Carmela
Lonardo, Amedeo
Marra, Fabio
Mancini, Marcello
Miele, Luca
Nobili, Valerio
Baroni, Gianluca Svegliati
Alessandro, Federico
Ballestri, Stefano
Brunetto, Maurizia Rossana
Coco, Barbara
Grieco, Antonio
Kondili, Loreta
Nascimbeni, Fabio
Prinster, Anna
Romagnoli, Dante
Taddei, Stefano
Vella, Stefano
Miele, Luca (ORCID:0000-0003-3464-0068)
Grieco, Antonio (ORCID:0000-0002-0544-8993)
Petta, Salvatore
Valenti, Luca
Bugianesi, Elisabetta
Targher, Giovanni
Bellentani, Stefano
Bonino, Ferruccio
Fargion, Silvia
Vanni, Ester
Ferrannini, Ele
Loguercio, Carmela
Lonardo, Amedeo
Marra, Fabio
Mancini, Marcello
Miele, Luca
Nobili, Valerio
Baroni, Gianluca Svegliati
Alessandro, Federico
Ballestri, Stefano
Brunetto, Maurizia Rossana
Coco, Barbara
Grieco, Antonio
Kondili, Loreta
Nascimbeni, Fabio
Prinster, Anna
Romagnoli, Dante
Taddei, Stefano
Vella, Stefano
Miele, Luca (ORCID:0000-0003-3464-0068)
Grieco, Antonio (ORCID:0000-0002-0544-8993)
Publication Year :
2016

Abstract

The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g. the definition of risk, prognosis, diagnosis criteria, and new endpoints of clinical trials). Based on this premise and in light of recent findings, the complex mechanisms involved in the pathology of fatty liver and their impact on the short- and long-term clinical outcomes of cardiovascular, metabolic liver diseases associated with steatosis are presented in this review using a new "systems medicine" approach. A new data set is proposed for studying the impairments of different physiological systems that have an impact on fatty liver in different subsets of subjects and patients.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1105029727
Document Type :
Electronic Resource