251. Tranexamic Acid: A Potential Adjunct to Resectoscopic Endometrial Ablation
- Author
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Bulent Ergun, Cem Celik, Mehmet Özsürmeli, and Ercan Bastu
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Treatment outcome ,Abnormal uterine bleeding ,Outcomes ,Drug Administration Schedule ,law.invention ,Blood loss ,Randomized controlled trial ,law ,medicine ,Humans ,Endometrial ablation ,Menorrhagia ,Endometrial Ablation Techniques ,business.industry ,Randomized-Controlled-Trial ,Uterine bleeding ,Resection ,Combined Modality Therapy ,Surgery ,Plasminogen Inactivators ,Treatment Outcome ,Tranexamic Acid ,Anesthesia ,Gynaecological Surgery ,Abdominal Hysterectomy ,Female ,Uterine Hemorrhage ,Ill health ,Resectoscopic surgery ,business ,Tranexamic acid ,medicine.drug - Abstract
Abnormal uterine bleeding (AUB) is a substantial cause of ill health in women worldwide. In this study, our aim was to evaluate the effectiveness of endometrial ablation using a modified urologic resectoscope along with tranexamic acid in AUB. Sixty patients were enrolled in this study. All patients underwent resectoscopic surgery. Patients were randomly divided into two groups. Group 1 (n = 30) received 500 mg of tranexamic acid. Group 2 (n = 30) served as the control group and underwent surgery without the administration of tranexamic acid. Total pictorial blood loss assessment chart (PBAC) scores were significantly lower postoperatively (152.14 ± 9.65 versus 6.6 ± 0.90; P < 0.001). When stratified by the administration of tranexamic acid, the number of patients with a postoperative day 1 PBAC score ≤15 was higher in the tranexamic group (19 versus 13), whereas the number of patients with a post operative day 1 PBAC score >15 was lower in the tranexamic group (11 versus 17), but the differences were not statistically significant (P > 0.05). AUB is a complex disease that may need repeated treatments. In expert hands, the treatment rate of resectoscopic surgery seems acceptable. However, some patients may require additional interventions, like repeated surgery, hysterectomy, or a drug therapy in the long run. Introduction of tranexamic acid as a potential adjunct to rollerball endometrial ablation may present an interesting option that requires additional well-designed studies before firm conclusions can be made.
- Published
- 2013