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Tranexamic Acid: A Potential Adjunct to Resectoscopic Endometrial Ablation
- Source :
- International Surgery. 97:310-314
- Publication Year :
- 2013
- Publisher :
- International College of Surgeons, 2013.
-
Abstract
- Abnormal uterine bleeding (AUB) is a substantial cause of ill health in women worldwide. In this study, our aim was to evaluate the effectiveness of endometrial ablation using a modified urologic resectoscope along with tranexamic acid in AUB. Sixty patients were enrolled in this study. All patients underwent resectoscopic surgery. Patients were randomly divided into two groups. Group 1 (n = 30) received 500 mg of tranexamic acid. Group 2 (n = 30) served as the control group and underwent surgery without the administration of tranexamic acid. Total pictorial blood loss assessment chart (PBAC) scores were significantly lower postoperatively (152.14 ± 9.65 versus 6.6 ± 0.90; P < 0.001). When stratified by the administration of tranexamic acid, the number of patients with a postoperative day 1 PBAC score ≤15 was higher in the tranexamic group (19 versus 13), whereas the number of patients with a post operative day 1 PBAC score >15 was lower in the tranexamic group (11 versus 17), but the differences were not statistically significant (P > 0.05). AUB is a complex disease that may need repeated treatments. In expert hands, the treatment rate of resectoscopic surgery seems acceptable. However, some patients may require additional interventions, like repeated surgery, hysterectomy, or a drug therapy in the long run. Introduction of tranexamic acid as a potential adjunct to rollerball endometrial ablation may present an interesting option that requires additional well-designed studies before firm conclusions can be made.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Treatment outcome
Abnormal uterine bleeding
Outcomes
Drug Administration Schedule
law.invention
Blood loss
Randomized controlled trial
law
medicine
Humans
Endometrial ablation
Menorrhagia
Endometrial Ablation Techniques
business.industry
Randomized-Controlled-Trial
Uterine bleeding
Resection
Combined Modality Therapy
Surgery
Plasminogen Inactivators
Treatment Outcome
Tranexamic Acid
Anesthesia
Gynaecological Surgery
Abdominal Hysterectomy
Female
Uterine Hemorrhage
Ill health
Resectoscopic surgery
business
Tranexamic acid
medicine.drug
Subjects
Details
- ISSN :
- 25202456 and 00208868
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- International Surgery
- Accession number :
- edsair.doi.dedup.....521eb40fce0adc6f2b207561a416a082