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Melanosis coli (MC) refers to the condition characterized by abnormal brown or black pigmentation deposits on the colonic mucosa. However, the histopathological findings and genes associated with the pathogenesis of melanosis coli remain to be fully elucidated. The present study aimed to examine the histopathological features and differentially expressed genes of MC. This involved performing hematoxylin and eosin staining, specific staining and immunohistochemistry on tissues sections, which were isolated from patients diagnosed with MC. DNA expression microarray analysis, western blotting and immunofluorescence assays were performed to analyze the differentially expressed genes of melanosis coli. The results demonstrated that the pigment deposits in MC consisted of lipofuscin. A TUNEL assay revealed that a substantial number of apoptotic cells were present within the macrophages and superficial lamina propria of the colonic epithelium. Expression microarray analysis revealed that the significantly downregulated genes were CYP3A4, CYP3A7, UGT2B11 and UGT2B15 in melanosis coli. Western blotting and immunofluorescence assays indicated that the expression of CYP3A4 in the normal tissue was higher than in the MC tissue. The results of the present study provided a comprehensive description of the histopathological characteristics and pathogenesis of MC and for the first time, to the best of our knowledge, demonstrated that the cytochrome P450‑associated genes were significantly downregulated in melanosis coli. This novel information can be used to assist in further investigations of melanosis coli.

The mechanisms underpinning Kawasaki disease (KD) are incompletely understood. There is an unmet need for specific biomarkers for the early diagnosis of KD.Eighty-five KD patients suffering from acute-phase and subacute-phase KD, 40 healthy children, and 40 febrile children comprised the study cohort. An enzyme-linked immunosorbent assay was used to measure plasma levels of C1q, C1q-circulating immune complex (C1q-CIC), mannan-binding lectin-associated serine protease (MASP)-1, factor B, C4d, C3d, C5a, C5b-9 and CD59.Plasma concentrations of factor B and C5a in the acute phase were lower than those in healthy and febrile control groups (all P0.05). Compared with acute-phase KD patients, plasma concentrations of C1q, factor B, and C3d in KD patients were increased significantly (P0.05), but those of C4d, MASP-1 and CD59 decreased significantly (P0.05), in patients with sub-acute KD.These data suggest that more than one pathway in the complement system is activated in KD. Importantly, decreased plasma concentrations of factor B and C5a in the acute phase (6-10 d) could be employed as biomarkers for the early diagnosis of KD.

Aims Floral nectar plays a vital role in plant reproductive success by attracting pollinators. Nectar traits of a flower can depend directly on plant characteristics other than environmental factors and exhibit extensive flower- and plant-level variations. Studies on nectar traits frequently focused on intraplant variation for dichogamous plants, but few have paid attention to both intra-and interplant nectar variations in relation to plant characteristics. Revealing within-and among-plant variation and its relative magnitude is important for our understanding of how pollinator-mediated selection can act on nectar traits and evolution of nectar traits. Methods Through investigating protandrous Aconitum gymnandrum populations at the Alpine Meadows and Wetland Ecosystems Research Station of Lanzhou University, we examined the relationships between nectar production per flower and plant characteristics (e.g. flower position within inflorescences, floral sexual phases, flowering time, inflorescence size and floral attractive traits). Important Findings A. gymnandrum exhibited a declining gradient in the nectar volume along inflorescences, with more nectar in basal flowers than distal ones. Protandrous flowers of A. gymnandrum did not show gender-biased nectar production while the nectar volume varied with different stages of floral sexual phases. The significant correlation between the first flowering date of individuals and the mean nectar volume per flower was positive in 2013, but became negative in 2014, suggesting complex effects of biotic and abiotic factors. The mean nectar volume per flower was not related to inflorescence size (the number of total flowers per plant). Furthermore, nectar production was weakly associated with floral attractive traits (the petal width and the galea height), even if the effect of flowering time of individuals was removed, suggesting that the honesty of floral traits as signals of nectar reward for pollinators is not stable in this species.

Background Mutations within the ELANE gene, which encodes human neutrophil elastase, are the most common genetic causes of severe congenital neutropenia (SCN). No cases of SCN have been previously described from a Chinese population. Herein, we describe the clinical, hematologic and molecular characteristics of 7 Chinese SCN cases with novel ELANE mutations. Methods Seven Chinese pediatric patients (4 males and 3 females) with suspected SCN were enrolled in this study. Clinical data, peripheral blood, bone marrow and immune function were evaluated for SCN. ELANE genomic DNA and cDNA sequences from patients and potential carriers were analyzed using polymerase chain reaction (PCR) and direct sequencing. Results All the7 patients experienced recurrent infection (soft tissue, lung, oral cavity) during a period of 120 days. Noninfectious conditions such as anemia and osteopenia were found in most patients, and absolute peripheral neutrophil counts varied. DNA and cDNA sequencing demonstrated that the patients harbored a range of heterozygous ELANE gene mutations, including substitution, deletion, insertion and frame shift alterations. All the mutations had not been reported previously; however, no mutation carriers were identified among the parents or siblings, even in a family with 2 affected offspring. Conclusion SCN cases were identified for the first time in China, and all patients carried novel ELANE mutations. Granulocyte-colony stimulating factor (G-CSF) was an effective treatment for most of the SCN patients and prevented life-threatening bacterial infections.

Moisture susceptibility is one of the key issues of warm mix asphalt (WMA). In this research, the moisture susceptibility of asphalt mixtures and binders containing Sasobit warm mix additive was investigated in comparison to that of hot mixture asphalt (HMA) through laboratory aging experiments. The WMA asphalt mixtures were aged in the laboratory at three aging temperatures and times. The moisture susceptibility of the asphalt mixtures was measured through the laboratory immersed Marshall test and freeze-thaw splitting test. The surface free energy (SFE) of asphalt binders extracted from WMA asphalt mixtures was determined by the sessile drop method. The results show that the aging time and temperature have a significant effect on the improvement in moisture susceptibility in terms of both the freeze-thaw splitting strength ratios and the residual Marshall stability of asphalt mixtures containing Sasobit warm mix additive. The SFE of asphalt binders extracted from Sasobit warm mix increased with the aging time and temperature. The moisture susceptibility of the asphalt mixtures and binders containing Sasobit warm mixes was similar to or even greater than that of HMA aging under certain conditions.

Ginned cotton’s quality is one significant factor to evaluate the cotton grade and influence the yarn qualities. Ginned cotton is always mixed with contaminants during picking, storing, drying, transporting, purchasing, and processing. Manual evaluation is time consuming, labor intensive, and unreliable. This paper proposed a fast feature extraction algorithm is presented for the measurement of cotton defects in ginned cotton within a complex background. The edge of cotton defects are extracted from fusion of three channel image of color image. A criterion based on areas is proposed to achieve fast morphological analysis. The different defects can be inspected automatically based on different thresholds. The comparison experiments between measuring system and technician were done and analyzed. The costing time of measuring system was less than 30 seconds, and accuracy was 89.5%. The measuring results show the method can meet with the requirement of grade determination of ginned cottons.

We introduce in this paper an exact solvable BCS-Hubbard model in arbitrary dimensions. The model describes a p-wave BCS superconductor with equal spin pairing moving on a bipartite (cubic, square etc.) lattice with on site Hubbard interaction $U$. We show that the model becomes exactly solvable for arbitrary $U$ when the BCS pairing amplitude $\Delta$ equals the hopping amplitude $t$. The nature of the solution is described in detail in this paper. The construction of the exact solution is parallel to the exactly solvable Kitaev honeycomb model for $S=1/2$ quantum spins and can be viewed as a generalization of Kitaev's construction to $S=1/2$ interacting lattice fermions. The BCS-Hubbard model discussed in this paper is just an example of a large class of exactly solvable lattice fermion models that can be constructed similarly., Comment: 5 pages, 3 figures

Among patients with primary lung cancer, 75-80% present with non-small cell lung cancer (NSCLC). However, there is a lack of studies into the potential preventive effects of curcumin against the activation of autophagy in NSCLC. Therefore, the present study primarily focused on the protective role of curcumin in NSCLC. It was demonstrated that curcumin decreased the viability of the human lung cancer cells lines, A549 and H1299, in a time-and dose-dependent manner (P

Objective To investigate the predictive value of thrombospondin-2 (TSP-2) in assessing the response to intravenous immunoglobulin (IVIG) in children with acute Kawasaki disease (KD). Methods This was a cohort study with controls. 71 children with KD were recruited as the case group, including IVIG non-responder (n=17) and IVIG responder (n=54), and healthy children (n=27) and febrile children (n=30) were used as control groups. ELISA was used to measure plasma TSP-2 and TSP-1 levels. The rank-sum test was used to compare groups of non-normally distributed data. Predictive value was evaluated through the receiver operating characteristic (ROC) curve. Results Compared with the control groups, the plasma TSP-2 levels in acute KD were significantly elevated (TSP-2: 31.00 (24.02, 39.28) vs 21.93 (17.00, 24.73) vs 16.23 (14.00, 19.64) ng/mL, P

BACKGROUND Olfactory ensheathing cell transplantation is a promising treatment for spinal cord injury. Diffusion tensor imaging has been applied to assess various kinds of spinal cord injury. However, it has rarely been used to evaluate the beneficial effects of olfactory ensheathing cell transplantation. This study aimed to explore the feasibility of diffusion tensor imaging in the evaluation of functional recovery in rats with olfactory ensheathing cell transplantation after contusive spinal cord injury. MATERIAL AND METHODS Immunofluorescence staining was performed to determine the purity of olfactory ensheathing cells. Rats received cell transplantation at week 1 after injury. Basso, Beattie, and Bresnahan score was used to assess the functional recovery. Magnetic resonance imaging was applied weekly, including diffusion tensor imaging. Diffusion tensor tractography was reconstructed to visualize the repair process. RESULTS The results showed that olfactory ensheathing cell transplantation increased the functional and histological recovery and restrained the secondary injury process after the initial spinal cord injury. The fractional anisotropy values in rats with cell transplantation were significantly higher than those in the control group, while the apparent diffusion coefficient values were significantly lower. Basso, Beattie, and Bresnahan score was positively and linearly correlated with fractional anisotropy value, and it was negatively and linearly correlated with apparent diffusion coefficient value. CONCLUSIONS These findings suggest that diffusion tensor imaging parameters are sensitive biomarker indices for olfactory ensheathing cell transplantation interventions, and diffusion tensor imaging scan can reflect the functional recovery promoted by the olfactory ensheathing cell transplantation after contusive spinal cord injury.

This study was designed to investigate whether fractional anisotropy (FA) contributes to study pathologic changes in SCI. Here rats were divided into a control group and three injury groups. Those in the injury groups were administered a mild, moderate, and severe contusion injury at the T10 vertebral level, respectively. Three rats were randomly selected from each group at 6, 24 and 72 h after SCI for imaging examination. Magnetic resonance diffusion tensor imaging was FA and tractography. Once magnetic resonance was completed, blood was collected and serum levels of neuron specific enolase (NSE) and soluble protein-100β (S-100β) were determined. Then animals were sacrificed and histopathologic examination was conducted. The spinal cord in the SCI model rats produced prominent tissue damages characterized by neuronal injury in the affected regions. An obvious decrease in FA happened 24 h after SCI, and at 72 h, FA tended to be stable. There were significant differences in the serum levels of NSE and S-100β between 6 h and 24 h, respectively. FA significantly related with the serum testing results at 24 h. FA may be used as a marker for different severities of SCI. The optimal time for examination is at 24 h post-injury in rat.

In this paper we study the properties of cold bosons in two-dimensional optical lattices where Bose condensation occurs at a momentum point $\mathbf{k}$ with nonzero $k$-space Berry curvature. By combining results from both analytic and numerical approaches, the bulk and edge excitation spectra of the system are derived. We show that the boson system carries nonuniversal, nontopological temperature-dependent equilibrium angular momentum and edge current at low temperatures. The differences between boson systems with real- and $k$-space Berry curvature are pointed out. In particular, using a simple variational wave-function approach, we show that for bosons in a harmonic trap, the stability of the Bose-condensed state towards vortex formation is rather different in the two cases because of the different angular momentum scalings in the ground states.

Block-matching and 3D filtering (BM3D) has showngreat power for image denoising. By decomposing the BM3Drestored image into three orthogonal subbands, we find thatthe subband of the high-frequency component, of which thewavelet coefficients are less than a given threshold, has madesome true textures of the original image lost and, the PSNR ofthe restored image is pulled down. Therefore, in this paper, wepropose a modified BM3D algorithm to solve these problems. We diffuse the subband of the high-frequency component, ofwhich the wavelet coefficients are less than the threshold of theBM3D restored image to the corresponding subband of thenoisy image to get a new estimate by using an improveddirected diffusion equation model. The Laplace operator isreplaced by an anisotropic diffusion operator and two differentcoefficients are added in the two diffusion terms. By replacingthe corresponding subband of the BM3D restored image withthe new estimate, we obtain the improved denoising result. Experimental results demonstrate that the proposed methodachieves better performance than original BM3D algorithm interms of both removing noise and persevering the edges anddetails of the image.

Background: Although various inflammation-based indexes in esophageal carcinoma have been documented, but the prognostic value of the albumin-to-globulin ratio(AGR) and its correlation with fibrinogen in resectable ESCC remain unknown. Methods: The levels of pre-treatment serum common acute phase proteins (including CRP, albumin and fribrinogen) were retrospectively analyzed in 447 patients with ESCC who underwent surgical resection at our department. The prognostic value was explored by univariate and multivariate cox hazard analysis. The correlation between AGR and acute phase proteins were also analyzed. Results: Patients with decreased levels of AGR and increased CRP had significantly lower 5-year survival rates than those with higher AGR, not only in the whole ESCC cohort but also in the subgroups stratified according to the disease T, N classifications, and metastasis, whereas the other acute phase proteins were not independent prognostic factors for ESCC. In addition, a lower AGR level was observed more often in patients with a high fibrinogen level than in those with a low fibrinogen level. Spearman's rank correlation analysis revealed that the AGR level presented a negative correlation with the fibrinogen level (r =-0.317, p

In Mineral resource economics, a large amount of data stored in Excel files usually need to be shown in various charts for analyzing. Excel VBA provides a fast and easy way to create charts. This paper illustrates how to create batched combination charts of several mineral resources and their annual increments based on Excel VBA. Every step of creating process is illustrated in details and the Excel VBA codes are analyzed carefully. And the resulting combination charts are displayed to emphasize the different chart types and to prove the effectiveness of Excel VBA.

Four new securinega-type alkaloids, fluevirines A-D (1-4), along with ten known ones, were isolated from the twigs and leaves of Flueggea virosa. The structures of the new ones were elucidated by means of spectroscopic methods, and their absolute configurations were assigned by CD spectra. Among them, fluevirine A (1) was a novel CC-linked dimeric indolizidine alkaloid and showed weak antimicrobial activity against Staphylococcus aureus. (C) 2014 Elsevier Ltd. All rights reserved.

Min-Max localization algorithm is usually used to acquire the position of a sensor node in wireless sensor networks by the reason of its simpleness and low complexity. However, Min-Max algorithm provides a coarse position estimation. In order to increase its accuracy, an Extended Min-Max (E-Min-Max) algorithm has been proposed. In this paper we focus on this algorithm and propose an improved E-Min-Max algorithm to enhance its accuracy further. Simulations show that the improved E-Min-Max algorithm outperforms its original version in localization.

We report self-powered velocity and trajectory tracking sensor (VTTS) array for detecting object motion, velocity, acceleration and trajectory based on single-electrode triboelectric nanogenerator. The VTTS was fabricated by a cost-effective and simple-designed grid, which obtained the electric signals by the charge transition between the electrodes and the ground according to the electrostatic induction of objects. A self-powered VTTS arrays (9×9 pixels) with low-node mode was prepared and realized the real-time tracking of position, velocity, acceleration and trajectory for a moving object by visual observation. Using the simply electrode weave technique, a high-resolution VTTS with 41×41 pixels on an active size of 1×1 cm2 was obtained and it only needs the 41+41=82 output ports. The device can detect a tiny displacement and trajectory for the high resolution of 250 μm. This work may provide a innovate design for preparing VTTS with ultrahigh pixels and low-cost.

To avoid the effect of the error of dielectric volume fraction brought by fabricating process on band gap, the diamond crystals with different the error of dielectric volume fraction were designed and fabricated to investigate the fluctuation of band gaps. Theses photonic crystals with a diamond structure were fabricated using alumina by stereolithography, gel-casting and sintering. The photonic band gaps were observed along direction and the photonic band gaps were formed in different frequency range. Increasing the radius from 4.2mm to 4.32mm and changing band width from 0.8 to 1.39GHz, the radius is increased by 2.86%, and corresponding band width increased by 73.75%. Therefore, the fabrication error in mold and fabrication process including injecting mold, sintering should be maintained under the same conditions, which can retain the error of band gap.

Investigation of the alkaloids from Myrioneuron faberi, a plant unique to China, gave four pairs of enantiomers (1-4). (±)-β-Myrifabral A (1) and (±)-α-myrifabral A (2) formed an inseparable mixture of anomers (cluster A), as did (±)-β-myrifabral B (3) and (±)-α-myrifabral B (4) (cluster B). Their structures were determined by X-ray diffraction and NMR analysis. Compounds 1-4 possessed novel cyclohexane-fused octahydroquinolizine skeletons and represent the first quinolizidine alkaloids from the genus Myrioneuron. The epimers of cluster A (1 and 2) were modified and separated. In vitro, clusters A and B and their derivatives inhibited replication of hepatitis C virus (HCV, IC50 0.9 to 4.7 μM) with cytotoxicity lower than that of telaprevir.

This paper first analyzes the protocol used in video on demand system function, using method. Then this paper introduces the coding technology, according to the characteristics of streaming media network transmission, points out the case for network transmission code. This paper introduces the influence of patching algorithm, greedy algorithm, elegant patch algorithm and cycle algorithm on streaming media height algorithm. The paper presents research on algorithm of video on demand scheduling by protocol of video on demand and multimedia encoding technology.

Five two-dimensional (2D) metal–organic coordination polymers, [M(D-cam)(bbbm)][M(L-cam)(bbbm)] [M = Co (1), Ni (2) and Zn (3)], [CuII(OH)(bbbm)(H2O)]2(NO3)2·2H2O (4) and [CuI(bbbm)2](HCOO) (5) [H2cam = camphoric acid and bbbm = 1,1-(1,4-butanediyl)bis-1H-benzimidazole], have been hydrothermally synthesized and structurally characterized. Complexes 1–3 are isostructural and possess three-dimensional (3D) supramolecular architectures based on two types of homochiral layers. Both 4 and 5 exhibit (4,4) layer structures, which are extended into 3D supramolecular architectures by hydrogen bonding and π–π stacking interactions, respectively. The magnetic properties of 4, as well as the thermostable and photoluminescent properties of 1–5 have been investigated.

The AZ31 alloy ingot with diameter of 110 mm and length of 3500 mm was fabricated successfully. The compositions and microstructure morphologies of the ingot at different locations were performed, which indicated that the chemical composition distributed homogeneously through the whole alloy ingot and the average grain size increased from the surface to the center. The results of the EDS and element face-scanning illustrated that the eutectic compounds mainly consisted of β-Mg17Al12 and a small amount of β-Mg17(AlZn)12. Furthermore, slight improvements of the strength and ductility were observed from the center to the surface along the axial direction of the alloy ingot, while both the strength and elongation to failure of the samples along the radial direction are higher than that along the axial direction. The fine grain strengthening was the main contributors to the strength of the as-casted AZ31 alloy.

The kinetic resolution of 4-substituted-3,4-dihydrocoumarins was realized via Pd-catalyzed allylic substitution reaction using Trost's chiral ligand L12, affording optically active mono- and trans-3,4-disubstituted dihydrocoumarin derivatives in high yields and with high enantioselectivities with an S factor up to 55.

The spectroscopic behavior of a photochromic compound 5, 11, 17, 23-tetra-tert-but yl-25, 27-bis (1’,3’,3’-trimethyl-6-nitrospiro-[2-H-1-benzopyran-2,2’-indoline]-8-methoxycarbonylmethoxy)-26,28-dihydroxycalix [4] arene (1) and its complex with lanthanum nitrate was described. Compound 1 has typical photochromic properties for its two spirobenzopyran groups. The complexation spectroscopic behavior has been investigated in anhydrous acetonitrile by UV-vis, fluorescence spectra and ESR spectra. The results obtained proved the formation of complexes and indicated that the spectroscopic behavior of the supramolecular system could be regulated by light. The system might be used as on-off switches.

To support the development of the PV industry, the China National Energy Bureau has issued some policies to stimulate the domestic PV market consumption, such as the “Golden Sun Demonstration Project”, “Building Integrated PV” policy. But these policies have some great vulnerability. Many developed countries, such as Germany, Japan, USA; they have some mature PV price settlement policies, such as Feed-in Tariff, Net Metering and Self-Consumption. Therefore, according to the needs of domestic situation, China National Energy Bureau needs to refer to those developed countries’ mature PV price settlement policies to formulate a PV price settlement policy. This policy must suit China PV market. And this policy should guide the development of domestic PV market correctly. Herein, I put forward some recommendations to improve our PV price settlement policy.

Four new acyclic diterpenoids (i.e., nemoralisin B (1) and nemoralisins H-J (2-4)) along with three known acyclic diterpenoids (i.e., nemoralisin, nemoralisin A, and nemoralisin D) were isolated from the fruits of Aphanamixis grandifolia. Their structures were determined by extensive spectroscopic studies using NMR spectroscopy and mass spectrometry. In addition, the structure of nemoralisin B has been revised from the previously reported a,beta-unsaturated delta-lactone structure to an a,beta-unsaturated glactone one. Nemoralisin J (4) exhibited moderate inhibitory activity against lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells with an IC50 value of 9.96 mu M. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

The fluorescence of N-methyl-1-naphthymethylamine (NA) was reversible modulated by acid and base based on switching photoinduced electron transfer (PET) process, which constituted a reversible on –off switch. However, addition of a calix [4] arene-spiropyran (Calix-2sp) derivative, which has absorption from 200 nm to 400 nm, caused that the fluorescence of protonated NA (NAH) was quenched and it could not be return to its initial high value by means of addition of acid again. Thus, the system made up of an INHIBIT logic gate.

In order to avoid the flaw including rigid regulations of architecture, strong coupling among modules, removal of fault and advanced technology embedding hard in 3D graphics render engine, a customizable architecture for 3D graphics render engine platform was proposed. The architecture introduced some simulation models which were design standard, expansibility, assembly relation of simulation component resource, development of typical modules and component design. Application developer could customize simulation assembly component flexibly and compose own 3D graphics render engine generally.

A new series of supramolecular hydrogen-bonded liquid cryatals complexes were synthesized based on pyridine derivative and 4-n-alkoxybenzoic acids. The formation of hydrogen bonds was verified by infrared spectra. The thermal behavior of supramolecular liquid crystals was studied using differential scanning calorimeter (DSC). The liquid crystal texture was revealed with polarizing optical microscope (POM). It demonstrats that all supramolecular complexes have good liquid crystal properties.

Spiramine C-D, the atisine-type diterpenoid alkaloids isolated from the Chinese herbal medicine Spiraea japonica complex, are shown to have anti-inflammatory effects in vitro. In this study, we report that spiramine derivatives of spiramine C-D bearing alpha,beta-unsaturated ketone induce apoptosis of Bax (/) /Bak (/) MEFs cell, which is positively corresponding their cytotoxicity of tumor cell lines including multidrug resistance MCF-7/ADR. The results indicated that oxazolidine ring is necessary, and derivatives bearing double 'Michael reaction acceptor' group would significantly increased activities both of inducing apoptosis of Bax (/) /Bak (/) cells and cytotoxicity of tumor cells. The result indicated that spiramine derivative with alpha,beta-unsaturated ketone group is a new anti-cancer agent with a capability of inducing apoptosis of cancer cells in Bax(-/-)/Bak(-/-) independent manner. (C) 2014 Elsevier Ltd. All rights reserved.

A three-dimensional (3D) homochiral metal-organic coordination polymer with a 6-connected 412.63 topology was synthesized hydrothermally, Cd4(D-cam)4(bbbm)2 (1) [D-H2cam = D-(+)-camphoric acid and bbbm = 1,1-(1,4-butanediyl)bis-1H-benzimidazole], which represents the first example of metal-camphorate coordination polymers constructed from two types of dinuclear cadmium clusters [Cd2(O2C–)4] and a flexible bis(benzimidazole)-based ligand. The thermal and photoluminescent properties of 1 were investigated.

The indoor molding methods don't match the actual degree of compaction, which will cause the compaction over one hundred degrees and the more reflective cracks of the cement stabilized macadam base. In order to prevent this kind of phenomenon, a series tests on two kinds different molding methods were conducted. It contained maximum dry density, UCS,drying shrinkage performance and impact of aggregates performance .The results show that the dry density and UCS(unconfined compressive strength) of vibration molding are greater than isostatic pressing method's, the drying shrinkage performance of vibration molding is better than static pressure molding's. The vibration molding has less affected for the aggregate performance. It is more similar to the actual field.

Five hetisane-type C20-diterpenoid alkaloids, trichodelphinines A-E, one delnudine-type C20-diterpenoid alkaloid, trichodelphinine F and three known flavonoids, quercetin, quercetin 3-O-β-D-glucopyranoside, and quercetin 3-O-β-D-glucopyranoside-7-O-α-L-arabinopyranoside, were isolated from whole plants of Delphinium trichophorum Franch. Their structures were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, NOESY and X-ray crystallographic analysis, and from chemical evidence. The cytotoxic activities of the diterpenoid alkaloids were evaluated using the MTT method, and the IC50 values of their cytotoxicity against A549 cancer cells ranged from 12.03 to 52.79 μM.

Background. The pretreatment albumin and globulin ratio (AGR) was an inflammation-associated factor which was related to the overall survival in various malignancies. The aim of this study was to evaluate the prognostic value of AGR in patients with gastric cancer. Method. This retrospective study included 862 cases pathologically diagnosed with gastric cancer. All patients were randomly divided into the testing group (431 cases) and validation group (431 cases). The relationships of AGR with clinicopathologic characteristics and prognosis were analyzed by Kaplan-Meier and Cox regression methods. Results. In the testing group, the median overall survival was 26.90 months and the cutoff value of AGR was 1.50 based on R language. Kaplan-Meier analysis showed that lower AGR was correlated with poorer overall survival. Multivariate analysis demonstrated that AGR was an independent prognostic factor for overall survival (HR: 0.584, 95% CI = 0.351–0.973, and p = 0.039). In the validation group, the median overall survival was 24.10 months. Lower AGR (≤1.50) also had a significantly poorer overall survival by Kaplan-Meier analysis. According to multivariate analysis, the AGR was also confirmed to be an independent prognostic factor for overall survival (HR: 0.578, 95% CI = 0.373–0.897, and p = 0.015). Conclusions. Our study suggested that the pretreatment AGR could be a prognostic biomarker for overall survival in patients with gastric cancer.

Background: Serum lipids have been documented as prognostic biomarkers in several types of cancer, however the prognostic value of serum lipids in non-esophageal squamous cell carcinoma (non-ESCC) is not clear. The purpose of this study was to investigate the prognostic roles of serum lipids in non-ESCC and to establish a novel effective nomogram for overall survival (OS) and disease-free survival (DFS) in patients with non-ESCC. Methods: We retrospectively analyzed the prognostic values of pretreatment serum lipids, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoproteinA-I (ApoAI), and apolipoprotein B (ApoB) and three lipid derivatives: atherogenic index [AI: (TC−HDL-C)/HDL-C], THR (TG/HDL-C) and LHR (LDL-C/HDL-C) in non-ESCC patients. Prognostic factors predictive of OS and DFS were determined by univariate and cox hazards analysis, and prognostic nomograms were established. The predictive power of independent prognostic factors was compared adopting time-dependent ROC. Comparisons between the nomograms and traditional TNM staging systems were evaluated using the C-index and decision curve analysis. Results: A total of 180 non-ESCC patients were recruited in this prospective study between January 2006 and December 2016. Four (cancer type, TNM stage, TC, and TG) and five (cancer type, TNM stage, TC, TG, and LDL-C) independent prognostic factors were chosen to generate the nomogram for OS and DFS, respectively. Our results showed that the area under curves (AUCs) of cancer type and TG were higher than TNM stage for OS. For DFS, however, AUCs of cancer type, TG and LDL-C were higher than the TNM stage. The C-index of the nomogram for predicting the OS was 0.69, which was significantly higher than that of TNM stage (0.58, P=0.005). In addition, for DFS, the C-index of the nomogram was significantly higher than that of the TNM stage (0.70 vs . 0.60, P=0.001). Furthermore, decision curve analysis showed that the predictive accuracy of the prognostic nomogram for OS and DFS were both higher than the TNM stage. Conclusions: Our study demonstrated that pretreatment of serum lipids based on the prognostic nomogram could be applied to predict the OS and DFS in non-ESCC patients.

A Pd-catalyzed intramolecular asymmetric allylic alkylation (AAA) reaction with "hard" carbanions has been developed for the first time, affording 2,3-disubstituted indanones with high diastereo- and enantioselectivities. The transformation of these products into other core structures of natural products has been demonstrated.

With the development of digital medical technology and Internet-related technology, the hospital's diagnosis and treatment become more and more inseparable from the work of modern digital imaging findings. The traditional way of medical image management services cannot meet the requirements of the new health care, so application of digital image management has become a top priority. With international and domestic regional medical information integration and sharing of system construction, imaging data center will serve as the core component of regional medical clinical information sharing system.

Effect of microorganisms and nickel sulfide ore before and after bioleaching on the emulsification was investigated. The emulsion stability was evaluated by the disengagement time or the production rate of crud. The results indicate that no crud formed and the disengagement time of system was prolonged with increasing bacteria density. And a large number of bacteria dispersed at the water-oil interface and aqueous phase and rarely existed in organic phase. The influence of bacteria on the emulsion stability was attributed to the structural characteristics and the mass transfer viscosity. And the emulsion with nickel sulfide ore after bioleaching was more stable, characterized as higher production rate of crud and lower light transmittance of aqueous phase, because bacteria alter the surface properties of minerals and increase particles’ hydrophilicity.

It is studied that Modern Design Methods based on Pro/Engineer software. The building process of rapid design platform of gear box is given systematically by applying top-down design techniques of data sharing mode, parametric modeling tools of standard parts, interchangeable parts library and kinematic simulation analysis methods. The solid modeling and simulation analysis of gear box is completed. The rapid design platform can provide technical support for manufacturing companies to adapt to quick changes of market and to research and develop series products efficiently.

This paper introduces the definition of ottoman stitch in details, provides some fabric panels of ottoman and describes the appearance of fabric structure. In addition, the knitting method and technology design for whole-ottoman and part-ottoman in Knit CAD are introduced and analyzed respectively. Finally, some typical examples for application of ottoman on sweater design are enumerated, which can enlarge and enrich the fields of sweater design.

The way of fault characteristic parameters fuzzy processing and optimizing the weights and thresholds of ANN by GA are studied. As a result, the convergent rate and convergent precision are greatly increased. Application to the fault diagnosis of a air blower system shows the new model overcomes the low learning rate and local optima of BP algorithm, and the fault diagnosis precision is effectively improved.

Cloud computing as a new network technology has been widely used in various fields, a important role of cloud computing is the storage and management for massive information data, therefore the cloud computing provides a good platform for data mining. This paper first describes simply on cloud computing, and then expounds and analyzes data mining application which based on cloud computing, finally introduces the data mining application based on cloud computing platform.

Time is the core of GPS satellite navigation system, and time service is one of the basic functions of the GPS system. The application of GPS technology in time service is more and more extensive, basing on its high accuracy, real-time, good continuity, low cost, etc.. In this paper, firstly, the building and maintaining of GPS time system is summarized, then GPS time service technology and GPS time transfer technology and their practical application in society is illustrated furtherly, secondly the prospects of GPS in time service technology and time transfer technology are discussed. With the development of GPS system performance and data processing technology, its application in time-frequency domain will widen continuously, which has important society significance for country's economic construction, national security and scientific research, etc.