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There is an urgent need to identify therapeutics for the treatment of Coronavirus disease 2019 (COVID-19). Although different antivirals are given for the clinical management of SARS-CoV-2 infection, their efficacy is still under evaluation. Here, we have screened existing drugs approved for human use in a variety of diseases, to compare how they counteract SARS-CoV-2-induced cytopathic effect and viral replication in vitro. Among the potential 72 antivirals tested herein that were previously proposed to inhibit SARS-CoV-2 infection, only 18 % had an IC50 below 25 µM or 102 IU/ml. These included plitidepsin, novel cathepsin inhibitors, nelfinavir mesylate hydrate, interferon 2-alpha, interferon-gamma, fenofibrate, camostat along the well-known remdesivir and chloroquine derivatives. Plitidepsin was the only clinically approved drug displaying nanomolar efficacy. Four of these families, including novel cathepsin inhibitors, blocked viral entry in a cell—type specific manner. Since the most effective antivirals usually combine therapies that tackle the virus at different steps of infection, we also assessed several drug combinations. Although no particular synergy was found, inhibitory combinations did not reduce their antiviral activity. Thus, these combinations could decrease the potential emergence of resistant viruses. Antivirals prioritized herein identify novel compounds and their mode of action, while independently replicating the activity of a reduced proportion of drugs which are mostly approved for clinical use. Combinations of these drugs should be tested in animal models to inform the design of fast track clinical trials. We are grateful to patients at the Hospital Germans Trias i Pujol that donated their samples for research. For his excellent assistance and advice, we thank Jordi Puig from Fundació Lluita contra la SIDA. We are most grateful to Lidia Ruiz and the Clinical Sample Management Team of IrsiCaixa for their outstanding sample processing and management, and to M. Pilar Armengol and the translational genomics platform team at the Institut de Recerca Germans Trias i Pujol. We truly thank B. Trinité for generating the Spike expression plasmid construct used in this study. We thank Pharma Mar, Rubió Laboratories, Janssen and Drs. Cabrera and Ballana form IrsiCaixa; Pascual-Figal, Lax and Asensio-Lopez MC from “Instituto de Investigación Biosanitaria IMIB-Arrixaca” of Murcia; and Fernández-Real and Barretina from the “Institut d'Investigació Biomèdica de Girona Dr Josep Trueta” for providing some of the reagents tested. Peer Reviewed "Article signat per 18 autors/es: Jordi Rodon, Jordana Muñoz-Basagoiti, Daniel Perez-Zsolt, Marc Noguera-Julian, Roger Paredes, Lourdes Mateu, Carles Quiñones, Carles Perez, Itziar Erkizia, Ignacio Blanco, Alfonso Valencia, Víctor Guallar, Jorge Carrillo, Julià Blanco, Joaquim Segalés, Bonaventura Clotet, Júlia Vergara-Alert, Nuria Izquierdo-Useros"

The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and their association with disease severity. Between March and May 2020, the prospective KING study enrolled 72 COVID-19+ participants grouped according to disease severity. SARS-CoV-2 infection was diagnosed by serological and virological tests. Plasma neutralizing responses were assessed against replicative virus and pseudoviral particles. Multiple regression and non-parametric tests were used to analyze dependence of parameters. The magnitude of neutralizing titers significantly increased with disease severity. Hospitalized individuals developed higher titers compared to mild-symptomatic and asymptomatic individuals, which together showed titers below the detection limit in 50% of cases. Longitudinal analysis confirmed the strong differences in neutralizing titers between non-hospitalized and hospitalized participants and showed rapid kinetics of appearance of neutralizing antibodies (50% and 80% of maximal activity reached after 11 and 17 days after symptoms onset, respectively) in hospitalized patients. No significant impact of age, gender or treatment on the neutralizing titers was observed in this limited cohort. These data identify a clear association of humoral immunity with disease severity and point to immune mechanisms other than antibodies as relevant players in COVID-19 protection. This work was partially funded by Grifols, the Departament de Salut of the Generalitat de Catalunya (Grant DSL0016 to JB and Grant DSL015 to JC), the Spanish Health Institute Carlos III (Grant PI17/01518 and PI18/01332 to JC) and the crowdfunding initiatives #joemcorono, BonPreu/Esclat and Correos. The funders had no role in study design, data collection and analysis, the decision to publish, or the preparation of the manuscript. EP was supported by a doctoral grant from National Agency for Research and Development (ANID)—Formation of Advanced Human Capital Program, Becas Chile: Grant 72180406. We are deeply grateful to all participant and to the technical staff of IrsiCaixa for sample processing. We also thank Daniel Pérez-Zsolt and Jordana Muñoz-Basagoiti for assistance with ACE-2 expressing 293T cell culture. Peer Reviewed "Article signat per 26 autors/es: Benjamin Trinité, Ferran Tarrés-Freixas, Jordi Rodon, Edwards Pradenas, Víctor Urrea, Silvia Marfil, María Luisa Rodríguez de la Concepción, Carlos Ávila-Nieto, Carmen Aguilar-Gurrieri, Ana Barajas, Raquel Ortiz, Roger Paredes, Lourdes Mateu, Alfonso Valencia, Víctor Guallar, Lidia Ruiz, Eulàlia Grau, Marta Massanella, Jordi Puig, Anna Chamorro, Nuria Izquierdo-Useros, Joaquim Segalés, Bonaventura Clotet, Jorge Carrillo, Júlia Vergara-Alert & Julià Blanco"

Mid-Cenozoic widespread arc magmatism in North Patagonia extends from the forearc to the retroarc zones, representing an anomalous large volume when compared to the present-day arc zone and even other past arc configurations. It represents a crucial stage in Andean arc evolution as was developed after a period of arc waning and within plate magmatism. Controversies exist regarding the origin of these volcanic sequences, with scarce integrated field, geochemical and geochronological analyses. We focused our study on the El Maitén Belt, located in the present-day retroarc zone, particularly on a poorly studied section corresponding to the southern outcrops of this volcanic belt. This volcanism consists of basaltic and andesitic lava flows and interbedded pyroclastic deposits, whose emplacement was controlled by extensional tectonics as indicated by the occurrence of wedge-like strata associated with normal faults. A U-Pb age on the basal part of this section shows that magmatic activity started by 37 Ma, earlier than previous studies that considered this volcanism as Oligocene. Geochemically, these rocks are part of the subalkaline and particularly tholeiitic series. All samples show trace element enrichments, depletions and ratios characteristic of arc magmas, though fluids and sediment imprint seem limited. On these bases, we propose decompression melting as the main process associated with the genesis of this volcanism. Therefore, this magmatic association constrained to the late Eocene represents the earliest evidence of arc volcanism in the Patagonian Andes, under an extensional regime, after a Paleogene waning of arc activity. Fil: Fernández Paz, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina Fil: Litvak, Vanesa Dafne. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina Fil: Echaurren Gonzalez, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina Fil: Iannelli, Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina Fil: Encinas, Alfonso. Universidad de Concepción; Chile Fil: Folguera Telichevsky, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina Fil: Valencia, Víctor. Washington State University. School Of Earth & Environmental Sciences; Estados Unidos

Desertification of Central Patagonia began between ~14–12 Ma and therefore was not directly connected to the opening of the Drake Passage and initial conformation of the Antarctica ice cap in early Miocene times. Local processes, in particular the uplift of the Southern Andes, seem to have played a major role in climatic and biotic changes. We studied synorogenic strata filling a partly cannibalized foredeep between ~45° and 47°S at the latitudes of the Chile triple juction. Older synorogenic successions have yielded 18.7–16.4 Ma (U-Pb) in the western sector of the North Patagonian Cordillera corresponding to Meseta Guadal, Jeinemeni and Alto de Río Cisnes sections. This uplift was partly contemporaneous with broken foreland deformation associated with the San Bernardo fold belt to the east at 17.7–15 Ma. Younger synorogenic successions of 13.5 Ma (U-Pb), associated with a short pulse of major uplift that gave way to deposition of a thick conglomeratic succession, and subsequently finer-grained deposits of 12.3 Ma, are on the eastern Andean front in the Chalía and Guenguell sections, implying a retraction in orogenic activity, and out-of-sequence growth of the Patagonian Cordillera. Consequently, contractional deformation in this area ended after ~12 Ma, sealed by the extrusion of extensive alkali flood basalts, indicating that Neogene shortening only lasted ~6 My, ending around 6 My before the subduction of the Chile Ridge at the latitudes of Central Patagonia and 4.5 My before subduction at the southern tip of South America. Fil: Folguera Telichevsky, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina Fil: Encinas, Alfonso. Universidad de Concepción; Chile Fil: Echaurren Gonzalez, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina Fil: Gianni, Guido Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; Argentina Fil: Orts, Darío Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación en Paleobiología y Geología; Argentina Fil: Valencia, Víctor. Washington State University; Estados Unidos Fil: Carrasco, Gabriel. Servicios Científicos Educativos y Turismo Científico Chile; Chile

El diseñador gráfico posee la capacidad no solo de crear piezas y estrategias de comunicación, sino que además de ser transmisor, posee las habilidades y herramientas de ser lector y más aún traductor de esas producciones visuales en un sentido de la sintaxis de la imagen, su significado y sus usos. El entendimiento de los lenguajes y expresiones en la actualidad es primordial para que un diseñador pueda comunicarse adecuadamente apoyándose de elementos y ayudas que le brinde el entorno social, en este caso los fenómenos relacionados con la gráfica urbana, el graffiti. En este estudio se pretende esclarecer a partir del análisis y desde la perspectiva gráfica, los elementos del graffiti, su intención comunicativa y su relación con el espacio donde están dispuestos, en este caso el Parque de Jovita. Este proyecto aporta a las escasas investigaciones analíticas acerca del tema, y además brinda una base para futuras investigaciones, planteando una detallada metodología de análisis complementada con entrevistas y aprovechando de los medios tecnológicos informáticos, para identificar y exponer elementos del graffiti en la ciudad de Cali, a partir del diseño e implementación de un modelo de análisis formal. Metodológicamente, se inicia este estudio en el año 2017, año en el cual se comienza la ubicación, registro fotográfico e identificación de las diferentes piezas de graffiti. Una vez realizado el proceso de selección y clasificación de piezas, se definieron el diseño de fichas de análisis, fotográfica y junto con el diseño de entrevistas se proponen algunas hipótesis acerca de los resultados alcanzados en cuanto a variables obtenidas y la relación graffiti, diseño gráfico y el espacio Proyecto de Grado (Diseñador de la Comunicación Gráfica) -- Universidad Autónoma de Occidente, 2018. Pregrado Diseñador(a) de la Comunicación Gráfica

The most important Cenozoic marine transgression in Patagonia occurred during the late Oligocene–early Miocene when marine waters of Pacific and Atlantic origin flooded most of southern South America including the present Patagonian Andes between ~41° and 47° S. The age, correlation, and tectonic setting of the different marine formations deposited during this period are debated. However, recent studies based principally on U–Pb geochronology and Sr isotope stratigraphy, indicate that all of these units had accumulated during the late Oligocene–early Miocene. The marine transgression flooded a vast part of southern South America and, according to paleontological data, probably allowed for the first time in the history of this area a transient connection between the Pacific and Atlantic oceans. Marine deposition started in the late Oligocene–earliest Miocene (~26–23 Ma) and was probably caused by a regional event of extension related to major plate reorganization in the Southeast Pacific. Progressive extension and crustal thinning allowed a generalized marine flooding of Patagonia that reached its maximum extension at ~20 Ma. It was followed by a phase of compressive tectonics that started around 19–16 Ma and led to the growth of the Patagonian Andes. The youngest (~19–15 Ma) marine deposits that accumulated in the eastern Andean Cordillera and the extra-Andean regions are coeval with fluvial synorogenic deposits and probably had accumulated under a compressive regime. Fil: Encinas, Alfonso. Universidad de Concepción; Chile Fil: Folguera Telichevsky, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina Fil: Bechis, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Diversidad Cultural y Procesos de Cambio. Universidad Nacional de Río Negro. Instituto de Investigaciones en Diversidad Cultural y Procesos de Cambio; Argentina Fil: Finger, Kennet. University of California; Estados Unidos Fil: Zambrano, Patricio. Universidad Andrés Bello; Chile Fil: Pérez, Andrés Felipe. Universidad de Concepción; Chile Fil: Bernabé, Pablo. Universidad de Concepción; Chile Fil: Tapia, Francisca. Universidad de Concepción; Chile Fil: Riffo, Ricardo. Universidad de Concepción; Chile Fil: Buatois, Luis Alberto. University of Saskatchewan; Canadá Fil: Orts, Darío Leandro. Universidad Nacional de Río Negro. Sede Alto Valle. Instituto de Investigaciones en Paleobiología y Geología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Nielsen, Sven Nikolaus. Universidad Austral de Chile. Instituto de Ciencias de la Tierra; Chile Fil: Valencia, Víctor V.. Washington State University; Estados Unidos Fil: Cuitiño, José Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Geología y Paleontología; Argentina Fil: Oliveros, Verónica. Universidad de Concepción; Chile Fil: De Girolamo Del Mauro, Lizet. Universidad de Concepción; Chile Fil: Ramos, Victor Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina

Una de las principales causas del problema de movilidad es el acelerado aumento de volúmenes vehiculares, en especial el de las motocicletas. Colombia, ocupa el segundo lugar en la producción de motocicletas en la región (MinCIT ) para el año 2013 se vendieron 644.751 motocicletas y para el año 2014 se obtuvo un aumento aproximado del 15%, estimando cifras superiores para el 2015. Este tema afecta los estudios donde se realiza la conversión a la unidad de automóvil equivalente para la homogenización del flujo, dicho concepto se vuelve insignificante y difícil de ser apropiado en el tránsito dominado por las motocicletas, debido a que el alto volumen y el comportamiento de éstas, demandan otra conversión. Un estudio de caso se ha desarrollado, con el objetivo de proponer un método para la generación de factores de conversión a la unidad de motocicletas, los cuales están en función de la velocidad y el espacio efectivo que presentan los vehículos al movilizarse por una corriente vehicular. Abstract: One of the main causes of mobility’s problem is the rapid increase in vehicle volumes, especially motorcycles. Colombia, ranks second in the production of motorcycles in the region (MinCIT), for 2013 644.751 motorcycles were sold and for 2014 an increase of approximately 15% was obtained, estimating higher figures for 2015. This issue affects studies where conversion is done to the equivalent car unit for the homogenization of the flow, this becomes an alternative concept but less appropriate when the traffic is dominated by motorcycles, due to the high volume and behavior, these demand another conversion. A case study has been developed with the aim of proposing a method for generating conversion factors to motorcycles unit, which are in function of the speed and vehicles effective space when they mobilize in a vehicular flow. Maestría

The gondwanan magmatism in the San Rafael Massif, known as Choiyoi Magmatic Cycle, was emplaced during the inception of a magmatic arc setting during the early Permian. Two different sections can be differentiated in this volcanic sequence. The lower section (~281 up to ~265 Ma) consisting of andesites and dacitic to low-silica rhyolitic ignimbrites has geochemical characteristics that indicate a subduction zone setting. The upper section (~265 up to ~252 Ma) composed of rhyolitic ignimbrites and lava flows, dacitic to rhyolitic subvolcanics and alkalic basaltic andesites has geochemical characteristics transitional between subduction and continental intraplate settings. Several Cu-(Mo) porphyry deposits are genetically linked to the lower section (Infiernillo, San Pedro and La Chilca-Zanjón del Buitre). In this paper, we discussed the petrogenesis of the magmatism linked to the porphyry deposits from the San Rafael Massif. The petrogenetic analysis suggests that the lower section was produced in a thickened crust resulting in an adakite-like signature magmatism. The U/Pb LA-ICP-MS age of magmatic zircons from an intrusive associated to the San Pedro porphyry (263.1 ± 4.2 Ma) allowed confirming that the emplacement of Cu-Mo porphyry deposits in the San Rafael Massif occurred during the change in the geodynamical conditions from a transpressive to a transtensive tectonic regime. Fil: Gómez, Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; Argentina Fil: Rubinstein, Nora Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; Argentina Fil: Valencia, Víctor A.. School Of Earth And Environmental Sciences; Estados Unidos

Elaboración de un modelo de scoring de seguimiento de cartera, para una entidad financiera colombiana que atiende clientes del segmento preferencial, vigilada por la Superintendencia Financiera de Colombia, y que pretende hacer una estimación correcta del nivel de riesgo de su cartera, para así determinar eficientemente las pérdidas esperadas (provisiones de cartera), y las pérdidas inesperadas (capital económico), para dar cumplimiento a las normas establecidas por el ente regulador en temas de cobertura de los activos, y a la par estar evaluando permanentemente el riesgo crediticio de la entidad y retroalimentando los procesos de originación de cartera, para que los mismos sean en un futuro mucho más ajustados para lograr disminuir al máximo el ingreso de clientes con perfiles de riesgo que sobrepasan los estándares predefinidos por la entidad -- En este orden de ideas, con base en la información cuantitativa y cualitativa proporcionada por el intermediario financiero, y realizando la minería de datos correspondiente, se determinaron las variables representativas para la medición del riesgo crediticio, posteriormente se desarrolló un modelo de scoring basado en la teoría estadística de la regresión logística, que determinara los niveles óptimos de pérdidas esperadas e inesperadas para este establecimiento de crédito, en la línea de Consumo del Segmento Preferencial, fijando los puntos de incumplimiento de la cartera

Although the Río de la Plata craton is exposed over a relatively large area in Uruguay, eastern Argentina, and southernmost Brazil, its geological evolution is poorly known because of great geological complexity and paucity of data. We report here U-Pb ages of detrital zircons from samples of five Neoproterozoic sandstone units deposited on the Río de la Plata Craton (RPC) in Uruguay and Argentina. The zircon ages provide definitive evidence of a great range of ages of rocks composing the craton-ages that would not have been known without the geochronology of detrital zircons. In turn, these new ages allow for a much fuller understanding of the nature and history of the craton. Quartz arenites of the Piedras de Afilar Formation show typical Transamazonian ages with peaks at 2.00-2.07, 1.87 and 1.78 Ga. However, the most important zircon population in the sample analyzed is Mesoproterozoic with maxima at 1.49, 1.35, 1.24 and 1.0 Ga. Archean zircons are subordinate. On the other hand, zircons recovered from two sandstone levels in the Arroyo del Soldado Group (Yerbal and Cerros San Francisco formations) are mostly Archean in age with maxima at 3.2 and 2.72-2.78 Ga. Palaeoproterozoic zircons are also prominent in this unit with peaks at 2.45 and 2.19, of which the latter is a typical Transamazonian age. Two samples from the Sierras Bayas Group in Tandilia (Argentina) show different age spectra. Sandstones of the Villa Mónica Formation have a unimodal zircon population of Transamazonian age with a peak at 2.15 Ga. Sandstones of the Cerro Largo Formation are characterized by a dominant Transamazonian zircon population with peaks at 2.15, 2.0 and 1.78, but also display important Archean-earliest Palaeoproterozoic (3.33, 2.99, 2.7, 2.46 Ga) and Mesoproterozoic peaks (1.55, 1.23 and 1.05 Ga). The abundance of Mesoproterozoic detrital zircons is surprising, given the limited outcrop area of Mesoproterozoic units in the RPC. Thus, the Mesoproterozoic orogenic event responsible for the generation of the dextral Sarandí del Yí megashear is much more important than previously assumed. A proto-Andean, Mesoproterozoic belt is suggested as the source of the Mesoproterozoic detritus. Archean rocks of the RPC crop out only in the Nico Pérez Terrane in Uruguay. The presence of Archean zircons in sandstones of the Sierras Bayas Group in Argentina suggests that the Nico Pérez Terrane was much closer to Tandilia than it is today. This is in accordance with the proposed sinistral reactivation of the Sarandí del Yí Shear Zone in the Cambrian, which resulted from tangential collision of the Cuchilla Dionisio-Pelotas Terrane. Finally, the conspicuous absence of Neoproterozoic zircons confirm other lines of evidence suggesting that the Neoproterozoic strata were deposited on a stable continental margin opening to the east and south. The Neoproterozoic basins had obviously no contribution whatsoever from Brasiliano-Pan African belts, supporting the idea of Cambrian terrane accretion as the mechanism responsible for the present configuration of the Río de la Plata Craton and the final amalgamation of Gondwana. © 2008 Elsevier B.V. Fil: Gaucher, Claudio. Departamento de Geología, Facultad de Ciencias, Iguá 4225, 11400 Montevideo; Uruguay Fil: Finney, Stanley C.. Department of Geological Sciences, California State University Long Beach, Long Beach, CA 90840-390; Estados Unidos Fil: Poire, Daniel Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; Argentina Fil: Valencia, Víctor A.. Geosciences, University of Arizona, 1040 E Fourth Street, Tucson, AZ 85721-0077; Estados Unidos Fil: Grove, Marty. Department of Earth & Space Sciences, University of California at Los Angeles, Los Angeles, CA 90095; Estados Unidos Fil: Blanco, Gonzalo. Departamento de Geología, Facultad de Ciencias, Iguá 4225, 11400 Montevideo; Uruguay Fil: Pamoukaghlian, Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; Argentina Fil: Gómez Peral, Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; Argentina