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1,365 results on '"Timmerman H"'

201. Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis

Author

Lutgendorff, F., Nijmeijer, R.M., Sandstrom, P.A., Trulsson, L.M., Magnusson, K.E., Timmerman, H., Minnen, L.P. van, Rijkers, G.T., Gooszen, H.G., Akkermans, L.M., Soderholm, J.D., Lutgendorff, F., Nijmeijer, R.M., Sandstrom, P.A., Trulsson, L.M., Magnusson, K.E., Timmerman, H., Minnen, L.P. van, Rijkers, G.T., Gooszen, H.G., Akkermans, L.M., and Soderholm, J.D.

Abstract

Contains fulltext : 183595.PDF (publisher's version ) (Open Access)

Published
2009

208. The use of animal models to study bacterial translocation during acute pancreatitis.

Author

Zorglijn GE/ONCO Medisch, Zorgeenheid Heelkunde Medisch, MMB, van Minnen, L.P., Blom, M., Timmerman, H., Visser, M.R., Gooszen, H.G., Akkermans, L.M.A., Zorglijn GE/ONCO Medisch, Zorgeenheid Heelkunde Medisch, MMB, van Minnen, L.P., Blom, M., Timmerman, H., Visser, M.R., Gooszen, H.G., and Akkermans, L.M.A.

Published
2007

209. New phtalazinones

Author

Hatzelmann, A., Boss, H., Häfner, D., Beume, R., Kley, H.P., Sterk, G.L., van der Mey, M., van der Laan, IJ., and Timmerman, H.

Published
1997

212. Piperidine derivatives

Author

Timmerman, H., Zhang, M.Q., Onogi, K., Takahashi, Y., Tamura, M., Toma, T., Wada, Y., Matsumoto, J., Kanke, T., and Medicinal chemistry

Published
1997

215. Tetrazole derivatives

Author

Timmerman, H., Zhang, M.Q., Onogi, K., Tamura, M., Toma, T., Wada, Y., Matsumoto, J., Kanke, T., and Medicinal chemistry

Published
1997

216. Heterologous expression of rat epitope-tagged histamine H2 receptors in insect Sf9 cells

Author

Beukers, M.W., Klaassen, C.H.W., de Grip, W.J., Verzijl, D., Timmerman, H., Leurs, R., and Medicinal chemistry

Subjects
SDG 3 - Good Health and Well-being, Large-scale production, purification and labeling of bovine rhodopsin by means of recombinant baculovirus, Grote-schaal produktie, zuivering en labeling van runder rhodopsine met behulp van recombinant baculovirus, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 25978.PDF (Publisher’s version ) (Open Access)

Published
1997

222. (Homo)piperazine derivatives

Author

Timmerman, H., Zhang, M.Q., Onogi, K., Tamura, M., Toma, T., Wada, Y., and Medicinal chemistry

Published
1997

229. Prenylamine derivatives as blockers of the vesicular transporter for dopamine

Author

Vaccari, A., Saba, P.L., Caldirola, M.P., Bijlo, G.J., Timmerman, H., and Medicinal chemistry

Subjects
SDG 6 - Clean Water and Sanitation
Abstract

A new series of diphenylalkylamine congeners of prenylamine have been assayed in binding experiments on rat striatal membrane preparations. The aim was to ascertain the influence of structural modifications and lipophilicity on their interaction with the [

Published
1997

237. Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding

Author

Verzijl, D., Pardo, L.M., van Dijk, M.A., Gruijthuijsen, Y.K., Jongejan, A., Timmerman, H., Nicholas, J., Schwarz, M., Murphy, P.M., Leurs, R., Smit, M.J., Verzijl, D., Pardo, L.M., van Dijk, M.A., Gruijthuijsen, Y.K., Jongejan, A., Timmerman, H., Nicholas, J., Schwarz, M., Murphy, P.M., Leurs, R., and Smit, M.J.

Abstract

The constitutively active G-protein-coupled receptor and viral oncogene ORF74, encoded by Kaposi sarcoma-associated herpesvirus (human herpesvirus 8), binds a broad range of chemokines, including CXCL1 (agonist), CXCL8 (neutral ligand), and CXCL10 (inverse agonist). Although chemokines interact with the extracellular N terminus and loops of the receptor, we demonstrate that helix 8 (Hx8) in the intracellular carboxyl tail (C-tail) of ORF74 directs chemokine binding. Partial deletion of the C-tail resulted in a phenotype with reduced constitutive activity but intact regulation by ligands. Complete deletion of the C-tail, including Hx8, resulted in an inactive phenotype that lacks CXCL8 binding sites and has an increased number of binding sites for CXCL10. Similar effects were obtained with the single R7.61

Published
2006
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248. Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists.

Author

Storelli, S., Verdijk, P., Verzijl, D., Timmerman, H., Stolpe, A. van de, Tensen, C.P., Smit, M.J., Esch, I.J. de, Leurs, R., Storelli, S., Verdijk, P., Verzijl, D., Timmerman, H., Stolpe, A. van de, Tensen, C.P., Smit, M.J., Esch, I.J. de, and Leurs, R.

Abstract

Item does not contain fulltext, A series of 3-phenyl-3H-quinazolin-4-ones have been synthesized and tested for affinity and activity at the chemokine CXCR3 receptor. The most potent compound (1d) has been evaluated using radioligand binding and calcium mobilization assays and is considered a useful tool for further characterization of the CXCR3 receptor.

Published
2005

249. Effect of antibiotics, prebiotics and probiotics in treatment for hepatic encephalopathy.

Author

Bongaerts, G.P.A., Severijnen, R.S.V.M., Timmerman, H., Bongaerts, G.P.A., Severijnen, R.S.V.M., and Timmerman, H.

Abstract

Contains fulltext : 48620timmerman.pdf (publisher's version ) (Closed access), In order to reduce ammonia production by urease-positive bacteria Solga recently hypothesised (S.F. Solga, Probiotics can treat hepatic encephalopathy, Medical Hypotheses 2003; 61: 307-13), that probiotics are new therapeutics for hepatic encephalopathy (HE), and that they may replace antibiotics and lactulose. This influenced our view of the effect of antibiotics, prebiotics, e.g., lactulose, and probiotics on intestinal bacteria in the treatment of HE. Intestinal ammonia arises from aminoacids after bacterial de-amination and not from urea making urease-positive bacteria irrelevant. Antibiotics are not preferred in the treatment of HE, since ammonia-producing antibiotic-resistant bacteria may survive and replace ammonia-producing antibiotic-susceptible bacteria. Intestinal prebiotics are carbohydrate-like compounds, such as lactulose and resistant starch, that beneficially affects host's health in a different manner than normal food. In the small bowel prebiotics are not absorbed and digested, but are fermented in the colon by colonic bacteria. Fermentation of prebiotics yields lactic, acetic and butyric acids, as well as gas especially hydrogen (H2). The massive H2 volumes cause rapid intestinal hurry and thus massive amounts of colonic bacteria, not only urease-positive bacteria, but also deaminating bacteria, are removed and intestinal uptake of toxic bacterial metabolites, e.g., ammonia, reduced. As living non-pathogenic micro-organisms, probiotics beneficially affect the host's health by fermenting non-absorbed sugars, especially in the small bowel. Thus, they reduce the substrate of the other bacteria, and simultaneously they create a surplus of fermentation products which may affect the non-probiotic flora. Regarding the fermentation products (lactic acid, ethanol, acetic acid and CO2) five groups of probiotic micro-organisms are known. It is argued that probiotic, CO2-producing (facultatively) heterolactic lactobacilli, i.e., lactobacilli, that produce bot

Published
2005

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