Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists.

Authors :: Storelli, S.
Verdijk, P.
Verzijl, D.
Timmerman, H.
Stolpe, A. van de
Tensen, C.P.
Smit, M.J.
Esch, I.J. de
Leurs, R.
Storelli, S.
Verdijk, P.
Verzijl, D.
Timmerman, H.
Stolpe, A. van de
Tensen, C.P.
Smit, M.J.
Esch, I.J. de
Leurs, R.
Source :: Bioorganic & Medicinal Chemistry Letters; 2910; 2913; 0960-894X; 11; 15; ~Bioorganic & Medicinal Chemistry Letters~2910~2913~~~0960-894X~11~15~~
Publication Year :: 2005
Abstract: Item does not contain fulltext<br />A series of 3-phenyl-3H-quinazolin-4-ones have been synthesized and tested for affinity and activity at the chemokine CXCR3 receptor. The most potent compound (1d) has been evaluated using radioligand binding and calcium mobilization assays and is considered a useful tool for further characterization of the CXCR3 receptor.

Database :: OAIster
Journal :: Bioorganic & Medicinal Chemistry Letters; 2910; 2913; 0960-894X; 11; 15; ~Bioorganic & Medicinal Chemistry Letters~2910~2913~~~0960-894X~11~15~~
Publication Type :: Electronic Resource
Accession number :: edsoai.on1284063203
Document Type :: Electronic Resource

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