Search

Given the complexity of today's world, we might need to work with numbers requiring multi-attribute functions, such as those having positive, neutral, and negative membership and those having truth, indeterminacy, and falsity membership. Adding these numbers together to get a single real number is the most important factor. In situations like this, decision-makers have more difficult choices and are unable to apply the single attribute function of the soft set theory. To address this constraint, the hyper-soft set theory with multi-attribute functions is introduced. We combine the notion of neutrosophic hypersoft set with picture fuzzy hypersoft set to form a single theory of neutrosophic picture hypersoft set in this study. We introduce the notions of correlation coefficient and weighted correlation coefficient and demonstrate its fundamental properties for neutrosophic picture hypersoft set. Then, we introduce the notions of a weighted average operator and a weighted geometric operator for neutrosophic picture hypersoft set by using the various aggregation operators with a suitable example. Making decisions based on several factors and choosing the best option is multi-criteria decision-making or MCDM. When ranking and choosing options based on a distance metric, one essential and useful strategy is the Technique of order preference by similarity to an ideal solution (TOPSIS). We demonstrate the accuracy of the fuzzy TOPSIS methodology by extending it to neutrosophic fuzzy TOPSIS and using neutrosophic picture hypersoft set theory to describe the MCDM problem in this study. We provide a generalized neutrosophic TOPSIS approach to demonstrate correlation coefficients and the effectiveness of this approach with an appropriate example. Finally, we offer a comparison to prior studies to demonstrate the viability of the proposed approach. [ABSTRACT FROM AUTHOR]

Background: Curcumin (Curcuma longa) is a well-known medicinal plant that induces autophagy in various model species, helping maintain cellular homeostasis. Its role as a caloric restriction mimetic (CRM) is being investigated. This study explores the potential of curcumin (CUR), as a CRM, to provide neuroprotection in D galactose induced accelerated senescence model of rats through modulation of autophagy. For six weeks, male rats received simultaneous supplementation of D-gal (300 mg/kg b.w., subcutaneously) and CUR (200 mg/kg b.w., oral). Method and results: The oxidative stress indices, antioxidants, and electron transport chain complexes in brain tissues were measured using standard methods. Reverse transcriptase-polymerase chain reaction (RT-PCR) gene expression analysis was used to evaluate the expression of autophagy, neuroprotection, and aging marker genes. Our results show that curcumin significantly (p ≤ 0.05) enhanced the level of antioxidants and considerably lowered the level of oxidative stress markers. Supplementing with CUR also increased the activity of electron transport chain complexes in the mitochondria of aged brain tissue, demonstrating the antioxidant potential of CUR at the mitochondrial level. CUR was found to upregulate the expression of the aging marker gene (SIRT-1) and the genes associated with autophagy (Beclin-1 and ULK-1), as well as neuroprotection (NSE) in the brain. The expression of IL-6 and TNF-α was downregulated. Conclusion: Our findings demonstrate that CUR suppresses oxidative damage brought on by aging by modulating autophagy. These findings imply that curcumin might be beneficial for neuroprotection in aging and age-related disorders. [ABSTRACT FROM AUTHOR]

Bioactive borosilicate glasses having weight composition (74-X) SiO2, 16 Na2O, 10 B2O3 and (X) V2O5 (wt%), where (X = 0, 0.1, 0.3, 0.5, 1, 2.5, 4 wt %) were synthesized using the conventional melting procedure. Bioactive glass samples were melted in a platinum crucible of 50 ml capacity at 1400 °C in the globular furnace with air as the furnace atmosphere and kept hold for 2 h. These glasses were characterised and tested by using several experiment techniques like XRD, FTIR, SEM and EDX. The bioactivity of the borosilicate samples was determined by submerging them in simulated body fluid (SBF) for different time intervals. The developed hydroxy apatite (HA) was identified by FTIR, XRD, SEM and EDX technique. The obtained results demonstrate that the in-vitro bioactivity of the samples increases with the increase in V2O5 doping in samples. Various properties like density, compressive strength and electrical properties are determined. Physical and mechanical properties are improved after V2O5 doping. Electrical properties are improved after SBF doping, and the result shows the ion movement due to increased bioactivity. The in-vitro hemocompatibility and cellular compatibility on MG-63 cell lines were carried out. It was found that samples were compatible with human blood. Cellular proliferation is increased with increasing concentration of V2O5. However beyond 0.5% V2O5 doping the value of bioactivity decreases at higher concentrations of samples in culture media. [ABSTRACT FROM AUTHOR]

Atlanto-occipital assimilation is an osseous embryological anomaly of the craniovertebral junction in which the atlas (C1) is fused to the occiput of skull. Embryologically, this assimilation may happen due to failure of the segmentation and separation of the caudal occipital and the cranial cervical sclerotome. The segmentation clock is maintained by NOTCH and WNT signalling pathways along with Hox genes and retinoic acid. This condition is likely to be a consequence of mutation in above mentioned genes. The knowledge of this assimilation may be crucial for the clinicians as it may lead to various neurovascular symptoms. The present case report involves the analysis of atlanto-occipital assimilation with its clinical significance and embryological basis. [ABSTRACT FROM AUTHOR]