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2,374 results on '"Simões M"'

203. Biofilm formation under high shear stress increases resilience to chemical and mechanical challenges.

Author

Simões, L. C., Gomes, I. B., Sousa, H., Borges, A., and Simões, M.

Subjects
SHEARING force, BENZALKONIUM chloride, SODIUM hypochlorite, BIOFILMS, STRAINS & stresses (Mechanics), PSEUDOMONAS fluorescens, STAINLESS steel
Abstract

The effect that the hydrodynamic conditions under which biofilms are formed has on their persistence is still unknown. This study assessed the behaviour of Pseudomonas fluorescens biofilms, formed on stainless steel under different shear stress ( τ w ) conditions (1, 2 and 4 Pa), to chemical (benzalkonium chloride – BAC, glutaraldehyde – GLUT and sodium hypochlorite – SHC) and mechanical (20 Pa) treatments (alone and combined). The biofilms formed under different τ w showed different structural characteristics. Those formed under a higher τ w were invariably more tolerant to chemical and mechanical stresses. SHC was the biocide which caused the highest biofilm killing and removal, followed by BAC. The sequential exposure to biocides and mechanical stress was found to be insufficient for effective biofilm control. A basal layer containing biofilm cells mostly in a viable state remained on the surface of the cylinders, particularly for the 2 and 4 Pa-generated biofilms. [ABSTRACT FROM AUTHOR]

Published
2022
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204. Seed germination of six Iberian endemic species – a contribution to enhance plant conservation.

Author

Fernandes, Mariana P., Pinto-Cruz, Carla, Almeida, Erika, Emídio, Marlene, Simões, M. Paula, Gazarini, Luiz, and Belo, Anabela D. F.

Subjects
PLANT conservation, GERMINATION, SPECIES, RESTORATION ecology, NATIVE plants, SOWING
Abstract

Biodiversity has been degraded all around the world due to anthropogenic factors. To counteract this worldwide tendency, ecological restoration programs are expanding. In these programs, the use of native herbaceous species, particularly those endemic or threatened, can be promoted by seeding them but germination requirements for most of these species are unknown. Our research meant to fill this gap of information for six Iberian endemic species suitable to use in restoration actions - Digitalis thapsi, Ferula communis subsp. catalaunica, Linaria amethystea subsp. amethystea, Pterocephalidium diandrum, Sanguisorba hybrida, and Silene scabriflora subsp. scabriflora. Their seed germination behaviour was analysed to establish germination protocols for conservation actions. Three germination conditions were used to simulate different sown seasons. Seeds of all species were tested without pre-treatment and subjected to a cold stratification. Seeds of S. hybrida and P. diandrum were additionally tested with a scarification treatment. All species reached their better germination performance under autumn conditions (15/10 °C; 8/16 hours). In conclusion, for all the six Iberian endemic species tested, germination speed and percentage were suitable for their use in native plants reinforcement. [ABSTRACT FROM AUTHOR]

Published
2021
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206. Utilização de radiação Ultravioleta (UV-C) como tecnologia alternativa aos sulfitos para a estabilização microbiológica de vinho tinto – Resultados prévios

Author

Alves,M., Grácio,J., Simões,M., and Mira,H.

Subjects
Wine, ultraviolet radiation, biology, Chemistry, microbiological stability, Flavour, vinho, General Medicine, Sensory profile, biology.organism_classification, Sensory analysis, estabilidade microbiológica, radiação ultravioleta, chemistry.chemical_compound, sulfites, Food science, wine, Control sample, Sulfur dioxide, Aroma, sulfitos
Abstract

Neste trabalho avaliou-se o efeito da radiação UV-C sobre a estabilidade microbiológica do vinho tinto e, também, a sua influência sobre alguns parâmetros físico-químicos e sobre o perfil sensorial. Assim, o vinho sem sulfitos foi submetido a radiação UV-C com duas doses diferentes, 778 J.L‑1 e 1415 J.L‑1, e procedeu-se ainda à preparação de um controlo a que foi adicionado 40 mg.L‑1 de dióxido de enxofre. Os vinhos (C, dose 1 e dose 2) foram analisados ao longo do tempo (0, 1, 2, 3, 6 e 9 meses). Os resultados obtidos demonstram que a tecnologia UV-C é eficaz no controlo microbiológico do vinho, não se diferenciando do tratamento tradicional para os parâmetros considerados. No que respeita às características físico-químicas, não se verificou diferenças entre os vários tratamentos para a maioria dos parâmetros analisados. Verifica-se que esta tecnologia tem um efeito muito positivo sobre a estabilidade da cor (intensidade e tonalidade) ao longo do tempo, comparativamente com o vinho com dióxido de enxofre. A análise sensorial revelou que os vinhos submetidos ao tratamento com radiação UV-C apresentaram uma melhor estabilização da cor, contudo verificou-se alguma depreciação no aroma e no sabor dos vinhos, que se atenuou ao longo do tempo., Revista de Ciências Agrárias, vol. 40 n.º spe (2017)

Published
2019
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207. Modeling a self-excited induction generator

Author

Simões, M. Godoy

Subjects
InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Reactive power (Electrical engineering), Electromagnetic fields, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Electric machinery, Induction, Induction generators
Abstract

Includes bibliographical references., Induction machines have been widely used in power generation and other industrial applications for decades due to their numerous advantages like robust design and lower cost as compared to synchronous machines. When a standalone induction generator like in isolated wind farm and micro hydro is driven by a mechanical prime mover, the residual magnetism in the rotor of the machine induces an electro-magnetic field (EMF) in the stator windings at a frequency proportional to the rotor speed. This EMF is applied to the capacitors (cap-bank) connected to the stator terminals and causes reactive current to flow in the stator windings. The capbank provides necessary reactive power to run the generator as well as reactive power to the inductive loads connected to the generator. Multiple generators can be connected in parallel to increase reliability and to provide required power for increasing loads. This paper presents a PSIM simulation model of a self-excited induction generator (SEIG) using the well-known [alpha beta gamma] three axis model for induction machines (IM). Transient response of standalone generator, two SEIG generators connected in parallel, and SEIG connected to grid is also part of this study. This paper is expected to be a learning module for electrical engineering students to understand dynamics of the induction machines.

Published
2019
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208. European perspective on 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: Proceedings of an interactive international symposium

Author

Luster, M. Aktolun, C. Amendoeira, I. Barczyński, M. Bible, K.C. Duntas, L.H. Elisei, R. Handkiewicz-Junak, D. Hoffmann, M. Jarzab, B. Leenhardt, L. Musholt, T.J. Newbold, K. Nixon, I.J. Smit, J. Sobrinho-Simões, M. Sosa, J.A. Tuttle, R.M. Verburg, F.A. Wartofsky, L. Führer, D.

Abstract

Background: The American Thyroid Association (ATA) management guidelines for patients with thyroid nodules and differentiated thyroid cancer (DTC) are highly influential practice recommendations. The latest revision appeared in 2015 ("ATA 2015"). These guidelines were developed predominantly by North American experts. European experts frequently have different perspectives, given epidemiological, technological/methodological, practice organization, and medicolegal differences between the respective regions. Summary: Divergent viewpoints were the focus of an invited symposium organized by the European Association of Nuclear Medicine involving 17 European thyroidologists, four ATA Guidelines Taskforce members, and an audience of 200 international experts. The group discussed the preoperative assessment of thyroid nodules, surgery and the role of pathology, radioiodine (RAI) therapy (RAIT), the assessment of initial therapy and dynamic risk stratification, and the treatment of persistent disease, recurrences, and advanced thyroid cancer. The dialogue resulted in this position paper contrasting European and ATA 2015 perspectives on key issues. One difference pertains to the permissiveness of ATA 2015 regarding lobectomy for primary tumors ≤4 cm. European panelists cited preclusion of RAIT, potential need for completion thyroidectomy, frequent inability to avoid chronic thyroid hormone replacement, and limitations of supportive evidence as arguments against widely applying lobectomy. Significant divergence involved ATA 2015's guidance regarding RAIT. European panelists favored wider use of postoperative RAIT than does ATA 2015. Rationales included the modality's association with favorable patient outcomes and generally limited toxicity, and lack of high-quality evidence supporting withholding RAIT. Additionally, European panelists favored recombinant human thyrotropin (rhTSH) in more settings than does ATA 2015, citing avoidance of hypothyroid morbidity and quality-of-life impairment, without apparent sacrifice in oncologic outcomes. Based on clinical evidence plus theoretical advantages, European experts advocated dosimetric versus fixed-activity RAIT approaches for advanced DTC. European panelists noted that the ATA 2015 risk-stratification system requires information sometimes unavailable in everyday practice. ATA 2015 recommendations regarding RAI-refractory DTC should consider potential palliative benefits of RAIT in patients who also have RAI-susceptible lesions. Conclusions: European panelists suggested modifications to approximately one-third of ATA 2015 recommendations. Varying European and ATA 2015 perspectives can stimulate analysis and discussion of the literature and performance of primary research to resolve discrepant recommendations and potentially improve patient outcomes. © Copyright 2019, Mary Ann Liebert, Inc., publishers 2019.

Published
2019

211. Influência do posicionamento no solo na decomposição de folhas e raminhos de Cistus salviifolius L

Author

Simões, M. P., Nunes, J., Gazarini, L., and Madeira, M.

Abstract

The influence of placement on litter decomposition dynamics was studied in the Mediterranean shrub Cistus salviifolius L. Litter bags containing either leaf or branch were placed at soil surface and others buried at 10 cm depth, in a Mediterranean shrubland of Alentejo, Southern Portugal. Changes in organic matter and nutrient content were assessed over a 2-year period. Decomposition was faster for leaves than for branches, as well as for buried residues than for those placed on soil surface. The annual decomposition rates, k, at surface were -0.71 for leaf and -0.17 for branches, while for buried litter they were -0.98 and -0.43, respectively. Organic matter decrease showed two phases: one initial decomposition phase of fast loss, mainly influenced by litter quality, followed by a very slow phase, influenced by both litter quality and placement. Nutrient dynamics was more influenced by litter initial chemical composition than by its placement, and the release was faster in the residues with the highest initial content, the leaves. The linear inverse relations, determined between remaining OM and N concentration in the remaining material, indicate longer N retention periods in the surface leaves than in buried ones., Estudou-se a influência do posicionamento no solo na dinâmica da decomposição de resíduos de arbustos mediterrânicos, numa comunidade característica de montados do Alentejo, durante um período de cerca de 2 anos. Para o efeito, monitorizaram-se as variações de matéria orgânica e de nutrientes em folhas e raminhos de Cistus salviifolius L. colocados na superfície do solo e incorporados a 10 cm de profundidade, através da técnica dos “sacos de decomposição” A taxa anual decomposição das folhas na superfície do solo (-0,71) foi mais rápida do que a dos raminhos em posição homóloga (-0,17). Esta diferenciação foi também observada para as folhas e raminhos incorporados a 10 cm de profundidade, tendo a taxa sido bastante mais elevada (respectivamente -0,98 e -0,43). A diminuição da matéria orgânica ocorreu em duas fases: uma fase inicial de decréscimo bastante rápido, influenciado principal-mente pela natureza do substrato, à qual se seguiu uma fase de decréscimo muito lento, no qual se fez sentir tanto o efeito do substrato como o da sua localização. A libertação dos nutrientes foi mais influenciada pela composição inicial dos resíduos do que pela localização destes no solo, tendo a libertação sido mais rápida nas folhas do que nos raminhos. As relações lineares inversas observadas entre a MO remanescente e a concentração de N no material residual indicam maiores períodos de imobilização de N nas folhas colocadas na superfície do que nas incorporadas no solo.

Published
2018

215. Conflation of expert and crowd reference data to validate global binary thematic maps

Author

Waldner, F., Schucknecht, A., Lesiv, M., Gallego, J., See, L., Pérez-Hoyos, A., d'Andrimont, R., de Maet, T., Laso Bayas, J.C., Fritz, S., Leo, O., Kerdiles, H., Díez, M., Van Tricht, K., Gilliams, S., Shelestov, A., Lavreniuk, M., Simões, M., Ferraz, R., Bellón, B., Bégué, A., Hazeu, G., Stonacek, V., Kolomaznik, J., Misurec, J., Verón, S.R., de Abelleyra, D., Plotnikov, D., Mingyong, L., Singha, M., Patil, P., Zhang, M., Defourny, P., Waldner, F., Schucknecht, A., Lesiv, M., Gallego, J., See, L., Pérez-Hoyos, A., d'Andrimont, R., de Maet, T., Laso Bayas, J.C., Fritz, S., Leo, O., Kerdiles, H., Díez, M., Van Tricht, K., Gilliams, S., Shelestov, A., Lavreniuk, M., Simões, M., Ferraz, R., Bellón, B., Bégué, A., Hazeu, G., Stonacek, V., Kolomaznik, J., Misurec, J., Verón, S.R., de Abelleyra, D., Plotnikov, D., Mingyong, L., Singha, M., Patil, P., Zhang, M., and Defourny, P.

Abstract

With the unprecedented availability of satellite data and the rise of global binary maps, the collection of shared reference data sets should be fostered to allow systematic product benchmarking and validation. Authoritative global reference data are generally collected by experts with regional knowledge through photo-interpretation. During the last decade, crowdsourcing has emerged as an attractive alternative for rapid and relatively cheap data collection, beckoning the increasingly relevant question: can these two data sources be combined to validate thematic maps? In this article, we compared expert and crowd data and assessed their relative agreement for cropland identification, a land cover class often reported as difficult to map. Results indicate that observations from experts and volunteers could be partially conflated provided that several consistency checks are performed. We propose that conflation, i.e., replacement and augmentation of expert observations by crowdsourced observations, should be carried out both at the sampling and data analytics levels. The latter allows to evaluate the reliability of crowdsourced observations and to decide whether they should be conflated or discarded. We demonstrate that the standard deviation of crowdsourced contributions is a simple yet robust indicator of reliability which can effectively inform conflation. Following this criterion, we found that 70% of the expert observations could be crowdsourced with little to no effect on accuracy estimates, allowing a strategic reallocation of the spared expert effort to increase the reliability of the remaining 30% at no additional cost. Finally, we provide a collection of evidence-based recommendations for future hybrid reference data collection campaigns.

Published
2019

227. Conoscopic image of a biaxial negative in a reentrant discotic – biaxial nematic phase transition.

Author

Luders, D.D., Arcolezi, G.M., Pereira, M.L.G., Braga, W.S., Santos, O.R., Simões, M., Kimura, N.M., Sampaio, A.R., and Palangana, A.J

Subjects
PHASE transitions, NEMATIC liquid crystals, DEUTERIUM oxide, LYOTROPIC liquid crystals, PHASE diagrams, DECANOL
Abstract

Conoscopic images have confirmed the occurrence of biaxial positive ( N B +) and biaxial negative ( N B − ) nematic phases between the two uniaxial nematic (discotic – N D and calamitic – N C ) phases. Biaxial positive ( N B + ) nematic phase was also optically characterised between two uniaxial N D phases. These nematic phases are found in different phase diagram lines of potassium laurate ( K L), decanol ( D e O H) and deuterium oxide ( D 2 O) lyotropic mixtures. In limited concentration range between the two phase diagram lines the following phase sequence ( N D → N B + → N B − → N B + → N D ) is determined here through conoscopic images. An analysis of the meaning of this result leads us to conclude that the biaxial nematic phase range between uniaxial nematic phases of phase diagrams with nematic lyotropic materials is separated in two regions: one has an optically positive signal and the other, having an optical negative signal. [ABSTRACT FROM AUTHOR]

Published
2021
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229. A 7 Year Old Girl with Vaginal Burn from Exposure to an Alkaline Battery

Author

Massa, AC, Tavares, M, Carvalho, T, and Simões, M

Subjects
Foreign body, Vaginal burn, Child, Alkaline batteries, MAC GIN
Abstract

Background: Vaginal burns resulting from alkaline batteries are a rare and potential serious complication which require a prompt intervention. Case: A 7-year-old girl presented to the emergency department with lower abdominal pain, dysuria and brownish vaginal discharge. Clinical history suggested a foreign body. Abdominal radiography showed two alkaline batteries inside the vagina that were removed. Vaginoscopy revealed severe vaginal burns with necrosis of a large area of posterior cul de sac. Two months after the girl was asymptomatic. Discussion: Vaginal foreign bodies should be considered in pre-pubertal girls presenting with vaginal bleeding. Its removal and assessment of direct effects should be immediately performed. info:eu-repo/semantics/publishedVersion

Published
2018

232. Isoflavones improve collagen I and glycosaminoglycans and prevent bone loss in type 1 diabetic rats

Author

Carbonel, A. A. F., primary, Vieira, M. C., additional, Simões, R. S., additional, Lima, P. D. A., additional, Fuchs, L. F. P., additional, Girão, E. R. C., additional, Cicivizzo, G. P., additional, Sasso, G. R. S., additional, de Moraes, L. O. Carvalho, additional, Soares Junior, J. M., additional, Baracat, E. C., additional, Simões, M. J., additional, and Girão, M. J. B. C., additional

Published
2019
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243. Treatment of Anemia with Darbepoetin Alfa in Systolic Heart Failure

Author

Karl Swedberg, James B. Young, Inder S. Anand, Sunfa Cheng, Akshay S. Desai, Rafael Diaz, Aldo P. Maggioni, John J. V. McMurray, Christopher O'Connor, Marc A. Pfeffer, Scott D. Solomon, Yan Sun, Michal Tendera, Dirk J. van Veldhuisen, Young J, Grinfeld L, Krum H, Vanhaecke J, Olivera Clausell N, Goudev A, Howlett J, Corbalan R, Hradec J, Kober L, Eha J, Cohen Solal A, Anker SD, Chopra V, Lewis B, Erglis A, Sakalyte G, Cardona Munoz E, Dunselman P, Dickstein K, Ponikowski P, Seabra Gomes R, Apetrei E, Mareev V, Murin J, Dalby A, Lopez Sendon J, Willenheimer R, Cleland J, Adams K, Anand I, Butler J, Dunlap M, Felker M, Ghali J, Levy W, Carson P, Cohn J, Drexler H, Pocock S, Ryden L, Poole Wilson P, Fishbane S, Ivanovich P, Nissenson A, Katz S, Barkoudah E, Campbell P, Desai A, Finn PV, Hartley L, Kasabov R, Odutayo KA, Rajesh V, Solomon S, Weinrauch LA, Albizem M, Cheng S, Chou W, Deegenaars M, Dougherty M, Fouqueray B, Froissart M, Froment A, Gadd S, Ghosh S, Grazette L, Guillet S, Gulabani D, Haddock B, Harris C, Jaffer A, Kerns C, Kim J, Knussel B, Law H, Mather R, Mix C, Moore L, Moyes R, Polu K, Rossert J, Scarlata D, Smirnakis K, Smith L, Snyder W, Sun Y, Trotman ML, Wasserman S, Watkins A, Wong M, Zhang Y, Amuchastegui M, Belziti C, Bluguermann J, Caccavo M, Cartasegna L, Colque R, Cuneo C, Fernandez A, Gabito A, Goicochea R, Gonzalez M, Gorosito V, Hominal M, Kevorkian R, Litvak Bruno M, Llanos J, Mackinnon I, Manuale O, Marzetti E, Nul D, Perna E, Riccitelli M, Sanchez A, Santos D, Schygiel P, Toblli J, Vogel D, Aggarwal A, Amerena J, De Looze F, Fletcher P, Hare D, Ireland M, Lattimore J, Marwick T, Sindone A, Thompson P, Waites J, Altenberger J, Ebner C, Lenz K, Pacher R, Poelzl G, Charlier F, de Ceuninck M, De Keulenaer G, Dendale P, Maréchal P, Mullens W, Thoeng J, Vanderheyden M, Weytjens C, Wollaert B, Albuquerque D, Almeida D, Aspe y. Rosas J, Bocchi E, Bordignon S, Clausell N, Kaiser S, Leaes P, Martins Alves S, Montera M, Moura L, Pereira de Castro R, Rassi S, Reis A, Saraiva J, Simões M, Souza Neto J, Teixeira M, Benov H, Chompalova B, Donova T, Georgiev P, Gotchev D, Grigorov M, Guenova D, Hergeldjieva V, Ivanov D, Kostova E, Manolova A, Marchev S, Nikolov F, Popov A, Raev D, Tzekova M, Czarnecki W, Giannetti N, Haddad H, Heath J, Huynh T, Lepage S, Liu P, Lonn E, Ma P, Manyari D, Moe G, Parker J, Pesant Y, Rajda M, Ricci J, Roth S, Sestier F, Sluzar V, Sussex B, Vizel S, Antezana G, Bugueno C, Castro P, Conejeros C, Manriquez L, Martinez D, Potthoff S, Stockins B, Vukasovic J, Gregor P, Herold M, Jerabek O, Jirmar R, Kuchar R, Linhart A, Podzemska B, Soucek M, Spac J, Spacek R, Vodnansky P, Bronnum Schou J, Clemmensen K, Egstrup K, Jensen G, Kjoller Hansen L, Markenvard J, Rokkedal J, Skagen K, Torp Pedersen C, Tuxen C, Videbak L, Laks T, Vahula V, Harjola V, Kettunen R, Kotila M, Bauer F, Coisne D, Davy J, De Groote P, Dos Santos P, Funck F, Galinier M, Gibelin P, Isnard R, Neuder Y, Roul G, Sabatier R, Trochu J, Denny S, Dreykluft T, Flesch M, Genth Zotz S, Hambrecht R, Hein J, Jeserich M, John M, Kreider Stempfle H, Laufs U, Muellerleile K, Natour M, Sandri M, Schäufele T, von Hodenberg E, Weyland K, Winkelmann B, Tse H, Yan B, Barsi B, Csikasz J, Dezsi C, Edes I, Forster T, Karpati P, Kerekes C, Kis E, Kosa I, Lupkovics G, Nagy A, Preda I, Ronaszeki A, Tomcsanyi J, Zamolyi K, Agarwal D, Bahl V, Bordoloi A, Chockalingam K, Chopda M, Dugal J, Ghaisas N, Grant P, Hiremath S, Iyengar S, Jagadeesa Subramania B, Jain P, Joshi A, Khan A, Mullasari A, Naik S, Oomman A, Pai V, Pareppally Gopal R, Parikh K, Patel T, Prakash V, Sastry B, Sathe S, Sinha N, Srikanthan V, Subburamakrishnan P, Thacker H, Wander G, Admon D, Katz A, Klainman E, Marmor A, Moriel M, Mosseri M, Shotan A, Weinstein J, Zimlichman R, Agostoni P, Albanese M, Alunni G, Bini R, Boccanelli A, Bolognese L, Campana C, Carbonieri E, Carpino C, Checco L, Cosmi F, Angelo GD, De Cristofaro M, Floresta A, Fucili A, Galvani M, Ivleva A, Marra S, Musca G, Peccerillo N, Picchio E, Russo T, Scelsi L, Senni M, Tavazzi L, Jasinkevica I, Kakurina N, Veze I, Volans E, Bagdonas A, Berukstis E, Celutkiene J, Dambrauskaite A, Jarasuniene D, Luksiene D, Rudys A, Sliaziene S, Aguilar Romero R, Cardona Muñoz E, Castro Jimenez J, Chavez Herrera J, Chuquiure Valenzuela E, De la Pena G, Herrera E, Leiva Pons J, Lopez Alvarado A, Mendez Machado G, Ramos Lopez G, Basart D, Buijs E, Cornel J, de Leeuw M, Dijkgraaf R, Freericks M, Hamraoui K, Lenderlink T, Linssen G, Lodewick P, Lodewijks C, Lok D, Nierop P, Ronner E, Somsen A, van Dantzig J, van der Burgh P, van Kempen L, van Vlies B, Voors A, Wardeh A, Willems F, Gundersen T, Hole T, Thalamus J, Westheim A, Dabrowski M, Gorski J, Korewicki J, Kuc K, Miekus P, Musial W, Niegowska J, Piotrowski W, Podolec P, Polonski L, Rynkiewicz A, Szelemej R, Trusz Gluza M, Ujda M, Wojciechowski D, Wysokinski A, Camacho A, Fonseca C, Monteiro P, Bruckner I, Carasca E, Coman I, Datcu M, Dragulescu S, Ionescu P, Iordachescu Petica D, Manitiu I, Popa V, Pop Moldovan A, Radoi M, Stamate S, Tomescu M, Vita I, Aroutiounov G, Ballyuzek M, Bart B, Churina S, Glezer M, Goloshchekin B, Kobalava Z, Kostenko V, Lopatin Y, Martynov A, Orlov V, Semernin E, Shogenov Z, Sidorenko B, Skvortsov A, Storzhakov G, Sulimov V, Talibov O, Tereshenko S, Tsyrline V, Zadionchenko V, Zateyshchikov D, Dzupina A, Hranai M, Kmec J, Micko K, Pella D, Sojka G, Spisak V, Vahala P, Vinanska D, Badat A, Bayat J, Dawood S, Delport E, Ellis G, Garda R, Klug E, Mabin T, Naidoo D, Pretorius M, Ranjith N, Van Zyl L, Weich H, Anguita M, Berrazueta J, Bruguera i. Cortada J, de Teresa E, Gómez Sánchez M, González Juanatey J, Gonzalez Maqueda I, Jordana R, Lupon J, Manzano L, Pascual Figal D, Pulpón L, Recio J, Ridocci Soriano F, Rodríguez Lambert J, Roig Minguell E, Romero J, Valdovinos P, Klintberg L, Kronvall T, Lycksell M, Morner S, Rydberg E, Swedberg K, Timberg I, Wikstrom G, Moccetti T, Ashok J, Banerjee P, Carr White G, Connolly E, Francis M, Greenbaum R, Kadr H, Lindsay S, McMurray J, Megarry S, Memon A, Murdoch D, Senior R, Squire I, Tan L, Witte K, Adamson P, Adler A, Altschul L, Altschuller A, Amirani H, Andreou C, Ansari M, Antonishen M, Banchs H, Banerjee S, Banish D, Bank A, Barbagelata A, Barnard D, Bellinger R, Benn A, Berk M, Berry B, Bethala V, Bilazarian S, Bisognano J, Bleyer F, Blum M, Boehmer J, Bouchard A, Boyle A, Bozkurt B, Brown C, Burlew B, Burnham K, Call J, Cambier P, Cappola T, Carlson R, Chandler B, Chandra R, Chandraratna P, Chernick R, Colan D, Colfer H, Colucci W, Connelly T, Costantini O, Dadkhah S, Dauber I, Davis J, Davis S, Denning S, Drazner M, Dunlap S, Egbujiobi L, Elkayam U, Elliott J, El Shahawy M, Essandoh L, Ewald G, Fang J, Farhoud H, Felker G, Fernandez J, Festin R, Fishbein G, Florea V, Flores E, Floro J, Gabris M, Garg M, Gatewood R, Geller M, Ghumman W, Gibbs G, Gillespie E, Gilmore R, Gogia H, Goldberg L, Gradus Pizlo I, Grainger T, Gudmundsson G, Gunawardena D, Gupta D, Hack T, Hall S, Hamroff G, Hankins S, Hanna M, Hargrove J, Haught W, Hauptman P, Hazelrigg M, Herzog C, Heywood J, Hill T, Hilton T, Hirsch H, Hunter J, Ibrahim H, Imburgia M, Iteld B, Jackson B, Jaffrani N, Jain D, Jain A, James M, Jimenez J, Johnson E, Kale P, Kaneshige A, Kapadia S, Karia D, Karlsberg R, Katholi R, Kerut E, Khoury W, Kipperman R, Klapholz M, Kosinski E, Kozinn M, Kraus D, Krueger S, Kumar S, Lader E, Lee C, Lewis E, Light McGroary K, Loh I, Lombardi W, Machado C, Maislos F, Mancini D, Markus T, Mather P, McCants K, McGrew F, McLaurin B, McMillan E, McNamara D, Meyer T, Meymandi S, Miller A, Minami E, Modi M, Mody F, Mohanty P, Moscoso R, Moskowitz R, Moustafa M, Mullen M, Naz T, Noonan T, O. 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D, Davy, J, De Groote, P, Dos Santos, P, Funck, F, Galinier, M, Gibelin, P, Isnard, R, Neuder, Y, Roul, G, Sabatier, R, Trochu, J, Denny, S, Dreykluft, T, Flesch, M, Genth Zotz, S, Hambrecht, R, Hein, J, Jeserich, M, John, M, Kreider Stempfle, H, Laufs, U, Muellerleile, K, Natour, M, Sandri, M, Schäufele, T, von Hodenberg, E, Weyland, K, Winkelmann, B, Tse, H, Yan, B, Barsi, B, Csikasz, J, Dezsi, C, Edes, I, Forster, T, Karpati, P, Kerekes, C, Kis, E, Kosa, I, Lupkovics, G, Nagy, A, Preda, I, Ronaszeki, A, Tomcsanyi, J, Zamolyi, K, Agarwal, D, Bahl, V, Bordoloi, A, Chockalingam, K, Chopda, M, Dugal, J, Ghaisas, N, Grant, P, Hiremath, S, Iyengar, S, Jagadeesa Subramania, B, Jain, P, Joshi, A, Khan, A, Mullasari, A, Naik, S, Oomman, A, Pai, V, Pareppally Gopal, R, Parikh, K, Patel, T, Prakash, V, Sastry, B, Sathe, S, Sinha, N, Srikanthan, V, Subburamakrishnan, P, Thacker, H, Wander, G, Admon, D, Katz, A, Klainman, E, Marmor, A, Moriel, M, Mosseri, M, Shotan, A, Weinstein, J, Zimlichman, 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Light McGroary, K, Loh, I, Lombardi, W, Machado, C, Maislos, F, Mancini, D, Markus, T, Mather, P, Mccants, K, Mcgrew, F, Mclaurin, B, Mcmillan, E, Mcnamara, D, Meyer, T, Meymandi, S, Miller, A, Minami, E, Modi, M, Mody, F, Mohanty, P, Moscoso, R, Moskowitz, R, Moustafa, M, Mullen, M, Naz, T, Noonan, T, O., Brien T, Oellerich, W, Oren, R, Pamboukian, S, Pereira, N, Pitt, W, Porter, C, Prabhu, S, Promisloff, S, Ratkovec, R, Richardson, R, Ross, A, Saleh, N, Saltzberg, M, Sarkar, S, Schmedtje, J, Schneider, R, Schuyler, G, Shanes, J, Sharma, A, Siegel, C, Siegel, R, Silber, D, Singh, N, Singh, J, Singh, V, Sklar, J, Small, R, Smith, A, Smith, E, Smull, D, Sotolongo, R, Staniloae, C, Stapleton, D, Steele, P, Stehlik, J, Stein, M, Tang, W, Thadani, U, Torre Amoine, G, Trichon, B, Tsai, C, Tummala, R, Van Bakel, A, Vicari, R, Vijay, N, Vijayaraghavan, K, Vittorio, T, Vossler, M, Wagoner, L, Wallis, D, Ward, N, Widmer, M, Wight, J, Wilkins, C, Williams, C, Williams, G, Winchester, M, Winkel, E, Wittmer, B, Wood, D, Wormer, D, Wright, R, Xu, Z, Yasin, M, Zolty, R., Faculteit Medische Wetenschappen/UMCG, and Cardiovascular Centre (CVC)

Subjects
Male, CHRONIC KIDNEY-DISEASE, Darbepoetin alfa, Ciencias de la Salud, Kaplan-Meier Estimate, law.invention, Hemoglobins, DOUBLE-BLIND, Randomized controlled trial, law, hemic and lymphatic diseases, Treatment Failure, Hazard ratio, Ética Médica, Anemia, General Medicine, Middle Aged, Shock, Septic, Stroke, purl.org/becyt/ford/3 [https], Female, medicine.drug, medicine.medical_specialty, CIENCIAS MÉDICAS Y DE LA SALUD, Placebo, CONTROLLED-TRIAL, purl.org/becyt/ford/3.3 [https], MORBIDITY, Double-Blind Method, Darbepoetin, Internal medicine, Thromboembolism, parasitic diseases, medicine, Humans, Adverse effect, Erythropoietin, Aged, Proportional Hazards Models, CITY CARDIOMYOPATHY QUESTIONNAIRE, business.industry, Proportional hazards model, MORTALITY, equipment and supplies, medicine.disease, Surgery, REDUCTION, EPOETIN, Heart failure, Hematinics, business, Systolic heart failure, Heart Failure, Systolic
Abstract

BACKGROUND: Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia. We evaluated the effects of darbepoetin alfa on clinical outcomes in patients with systolic heart failure and anemia. METHODS: In this randomized, double-blind trial, we assigned 2278 patients with systolic heart failure and mild-to-moderate anemia (hemoglobin level, 9.0 to 12.0 g per deciliter) to receive either darbepoetin alfa (to achieve a hemoglobin target of 13 g per deciliter) or placebo. The primary outcome was a composite of death from any cause or hospitalization for worsening heart failure. RESULTS: The primary outcome occurred in 576 of 1136 patients (50.7%) in the darbepoetin alfa group and 565 of 1142 patients (49.5%) in the placebo group (hazard ratio in the darbepoetin alfa group, 1.01; 95% confidence interval, 0.90 to 1.13; P=0.87). There was no significant between-group difference in any of the secondary outcomes. The neutral effect of darbepoetin alfa was consistent across all prespecified subgroups. Fatal or nonfatal stroke occurred in 42 patients (3.7%) in the darbepoetin alfa group and 31 patients (2.7%) in the placebo group (P=0.23). Thromboembolic adverse events were reported in 153 patients (13.5%) in the darbepoetin alfa group and 114 patients (10.0%) in the placebo group (P=0.01). Cancer-related adverse events were similar in the two study groups. CONCLUSIONS: Treatment with darbepoetin alfa did not improve clinical outcomes in patients with systolic heart failure and mild-to-moderate anemia. Our findings do not support the use of darbepoetin alfa in these patients. (Funded by Amgen; RED-HF ClinicalTrials.gov number, NCT00358215.). Fil: Swedberg, Karl. University of Gothenburg; Suecia Fil: Young, James B.. Cleveland Clinic; Estados Unidos Fil: Anand, Inder S.. University of Minnesota; Estados Unidos Fil: Cheng, Sunfa. Amgen; Estados Unidos Fil: Desai, Akshay S.. Brigham and Women’s Hospital; Estados Unidos Fil: Diaz, Rafael. Estudios Clínicos Latinoamérica; Argentina Fil: Maggioni, Aldo P.. Italian Association of Hospital Cardiologists Research Center; Italia Fil: McMurray, John J.V.. University of Glasgow; Reino Unido Fil: O’Connor, Christopher. University of Duke; Estados Unidos Fil: Pfeffer, Marc A.. Brigham and Women’s Hospital; Estados Unidos Fil: Solomon, Scott D.. Brigham and Women’s Hospital; Estados Unidos Fil: Sun, Yan. Amgen; Estados Unidos Fil: Tendera, Michal. Medical University of Silesia; Polonia Fil: van Veldhuisen, Dirk J.. University of Groningen; Países Bajos Fil: Toblli, Jorge Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

Published
2013

244. Antimicrobial screening of Plectranthus madagascariensis and P. neochilus extracts

Author

Pereira, Margarida, Matias, Diogo, Pereira, Filipe, Reis, Catarina P., Simões, M. F., and Rijo, Patrícia

Subjects
ANTIMICROBIANOS, natural products, Plectranthus spp, lcsh:RM1-950, CIÊNCIAS FARMACÊUTICAS, Antimicrobial activity, FARMACOLOGIA, FITOQUÍMICA, PHARMACEUTICAL SCIENCES, lcsh:Therapeutics. Pharmacology, extraction methods, PLANT CHEMISTRY, EXPERIÊNCIAS LABORATORIAIS, PLANTAS MEDICINAIS, PHARMACEUTICAL DRUGS, FÁRMACOS, ANTIMICROBIAL, MEDICINAL PLANTS, PHARMACOLOGY, LABORATORY EXPERIMENTS
Abstract

Natural products are widely used as traditional medicines and are a common source of bioactive molecules for the treatment of bacterial infections. In particular, some plants of the genus Plectranthus (Lamiaceae) have demonstrated several applications, including the treatment of various infections. In this work, aqueous, acetonic and methanolic extracts of P. madagascariensis and P. neochilus were prepared using several extraction methods (infusion, decoction, maceration, microwave- and ultrasoundassisted and supercritical fluids). All extracts were screened for their antimicrobial activity against Gram positive bacteria (Enterococcus faecalis, Staphylococcus aureus, Bacillus subtilis and Mycobacterium smegmatis) and Gram negative bacteria (Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli) and two yeast (Candida albicans and Saccharomyces cerevisiae) strains. The P. madagascariensis acetonic extracts obtained using ultrasound and maceration methods and P. neochilus acetonic extract obtained by ultrasound technique showed activity against the five tested Gram positive bacteria (5‒24 mm of inhibition zone using the well diffusion test). The antimicrobial activity was further evaluated by the microdilution method (MIC values were between 250‒0.49 μg/mL) and the bioautography assay against S. aureus. The P. madagascariensis ultrasound acetonic extract was the most active extract against all the tested Gram positive bacteria (MIC values ranged between 31.25 - 0.49 μg/mL). It was also active against resistant MRSA and VRE strains (MIC values ranged between 31.25-0.98 μg/mL). The S. aureus bioautography assay showed that the more polar compounds were the responsible for the antimicrobial activity., Os produtos naturais são amplamente utilizados como remédios tradicionais e são uma fonte comum de moléculas bioativas para o tratamento de infeções bacterianas. Em particular, algumas plantas do género Plectranthus (Lamiaceae) demonstraram diversas aplicações, incluindo no tratamento de várias infeções. Neste trabalho, foram preparados extratos aquosos, acetónicos e metanólicos de P. madagascariensis e P. neochilus utilizando vários métodos de extração (infusão, decocção, maceração, extração assistida por micro-ondas e por ultrassom e com fluidos no estado supercrítico). Todos os extratos foram testados quanto à atividade antimicrobiana face a bactérias de Gram-positivo (Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis Bacillus subtilis e Mycobacterium smegmatis) e de Gram-negativo (Pseudomonas aeruginosa, Klebsiella pneumoniae e Escherichia coli) e duas estirpes de leveduras (Candida albicans e Saccharomyces cerevisiae). O extrato acetónico de P. madagascariensis obtido pelas técnicas de ultrassom e maceração e o extrato acetónico de P. neochilus obtido pela técnica de ultrassom demonstraram atividade contra as cinco bactérias Gram-positivas testadas (5-24 mm de zona de inibição no teste de difusão). A atividade antimicrobiana foi ainda avaliada pelo método da microdiluição (valores de CMI entre 250-0,49 μg/mL) e pelo ensaio de bioautografia usando o S. aureus. O extrato acetónico de P. madagascariensis foi o mais ativo contra todas as bactérias de Gram positivo testadas (valores de CMI entre 31,25-0,49 μg/ml). Foi também ativo em bactérias resistentes a antibióticos: MRSA e VRE (valores de CMI entre 31,25-0,98 μg/mL). Os ensaios de bioautografia com S. aureus demonstraram que os compostos mais polares são os responsáveis pela sua atividade antimicrobiana.

Published
2015

247. Multimodality imaging evaluation of Chagas disease: an expert consensus of Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI)

Author

Nunes, M, Badano, L, Marin-Neto, J, Edvardsen, T, Fernández-Golfín, C, Bucciarelli-Ducci, C, Popescu, B, Underwood, R, Habib, G, Zamorano, J, Saraiva, R, Sabino, E, Botoni, F, Barbosa, M, Barros, M, Falqueto, E, Simões, M, Schmidt, A, Rochitte, C, Rocha, M, Ribeiro, A, Lancellotti, P, Nunes, Maria Carmo P, Badano, Luigi, Marin-Neto, J Antonio, Edvardsen, Thor, Fernández-Golfín, Covadonga, Bucciarelli-Ducci, Chiara, Popescu, Bogdan A, Underwood, Richard, Habib, Gilbert, Zamorano, Jose Luis, Saraiva, Roberto Magalhães, Sabino, Ester Cerdeira, Botoni, Fernando A, Barbosa, Márcia Melo, Barros, Marcio Vinicius L, Falqueto, Eduardo, Simões, Marcus Vinicius, Schmidt, André, Rochitte, Carlos Eduardo, Rocha, Manoel Otávio Costa, Ribeiro, Antonio Luiz Pinho, Lancellotti, Patrizio, Nunes, M, Badano, L, Marin-Neto, J, Edvardsen, T, Fernández-Golfín, C, Bucciarelli-Ducci, C, Popescu, B, Underwood, R, Habib, G, Zamorano, J, Saraiva, R, Sabino, E, Botoni, F, Barbosa, M, Barros, M, Falqueto, E, Simões, M, Schmidt, A, Rochitte, C, Rocha, M, Ribeiro, A, Lancellotti, P, Nunes, Maria Carmo P, Badano, Luigi, Marin-Neto, J Antonio, Edvardsen, Thor, Fernández-Golfín, Covadonga, Bucciarelli-Ducci, Chiara, Popescu, Bogdan A, Underwood, Richard, Habib, Gilbert, Zamorano, Jose Luis, Saraiva, Roberto Magalhães, Sabino, Ester Cerdeira, Botoni, Fernando A, Barbosa, Márcia Melo, Barros, Marcio Vinicius L, Falqueto, Eduardo, Simões, Marcus Vinicius, Schmidt, André, Rochitte, Carlos Eduardo, Rocha, Manoel Otávio Costa, Ribeiro, Antonio Luiz Pinho, and Lancellotti, Patrizio

Abstract

Aims To develop a document by Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI) to review and summarize the most recent evidences about the non-invasive assessment of patients with Chagas disease, with the intent to set up a framework for standardized cardiovascular imaging to assess cardiovascular morphologic and functional disturbances, as well as to guide the subsequent process of clinical decision-making.Methods and results Chagas disease remains one of the most prevalent infectious diseases in Latin America, and has become a health problem in non-endemic countries. Dilated cardiomyopathy is the most severe manifestation of Chagas disease, which causes substantial disability and early mortality in the socially most productive population leading to a significant economical burden. Prompt and correct diagnosis of Chagas disease requires specialized clinical expertise to recognize the unique features of this disease. The appropriate and efficient use of cardiac imaging is pivotal for diagnosing the cardiac involvement in Chagas disease, to stage the disease, assess patients' prognosis and address management. Echocardiography is the most common imaging modality used to assess, and follow-up patients with Chagas disease. The presence of echocardiographic abnormalities is of utmost importance, since it allows to stage patients according to disease progression. In early stages of cardiac involvement, echocardiography may demonstrate segmental left ventricuar wall motion abnormalities, mainly in the basal segments of inferior, inferolateral walls, and the apex, which cannot be attributed to obstructive coronary artery arteries. The prevalence of segmental wall motion abnormalities varies according to the stage of the disease, reaching about 50% in patients with left ventricular dilatation and dysfunction. Speckle tracking echocardiography allows a more precise and quantitative measurement of the regional myo

Published
2018

248. Exploiting compressive system identification for multiple line outage detection in smart grids

Author

Babakmehr, M., Harirchi, F., Al Durra, A., Muyeen, S.M., Simões, M., Babakmehr, M., Harirchi, F., Al Durra, A., Muyeen, S.M., and Simões, M.

Abstract

© 2018 IEEE Due to system complexity and structural variations, real time power line outage detection (POD) and localization is a critical and challenging monitoring goal for modern smart grid (SG). Online monitoring of power lines status plays a major role in system-wide cascading blackout prevention. In this work, we aim to address the multiple POD problems by exploiting the compressive system identification (CSI) - a time efficient approach in complex network analysis. We consider a power network (PN) as a single graph and the mathematical formulation of POD is initialized using the DC power-flow model and graph theory concepts. The POD sparse recovery problem (POD-SRP) reported earlier is improved and generalized in case of large-scale multiple outages. The technical challenges from sparse recovery perspective are addressed through developing new SRP solvers. Moreover, a new sparse-based mathematical formulation for POD is termed as 'Binary-POD-SRP' to specifically address the signal dynamic range issue. Finally, using the IEEE standard test-beds, it is discussed how the inherent challenges within large-scale multiple-outages can be solved by applying these new techniques and formulations.

Published
2018

250. A Remote Sensing Approach for Regional-Scale Mapping of Agricultural Land-Use Systems Based on NDVI Time Series

Author

BELLÓN, B., BEGUÉ, A., LO SEEN, D., ALMEIDA, C. A. de, SIMÕES, M., BEATRIZ BELLÓN, Cirad, UMR TETIS, AGNÈS BEGUÉ, Cirad, UMR TETIS, DANNY LO SEEN, Cirad, UMR TETIS, CLAUDIO APARECIDO DE ALMEIDA, INPE, and MARGARETH GONCALVES SIMOES, CNPS.

Subjects
Terre agricole, Télédétection, Analyse en composantes (statist), Sistema de Cultivo, Cartographie de l' utilisation des terres, Élevage, principal components analysis (PCA), F01 - Culture des plantes, Système d'information géographique, Couverture végétale, lcsh:Science, PCA, Utilisation des terres, Moderate Resolution Imaging Spectroradiometer (MODIS), GEOBIA, U10 - Informatique, mathématiques et statistiques, L01 - Élevage - Considérations générales, Agriculture, cropping systems, B10 - Géographie, MODIS, Estratificação, P31 - Levés et cartographie des sols, Système de culture, lcsh:Q, geographic object-based image analysis (GEOBIA), U30 - Méthodes de recherche, Plante de culture, Stratification, Analyse d'image
Abstract

In response to the need for generic remote sensing tools to support large-scale agricultural monitoring, we present a new approach for regional-scale mapping of agricultural land-use systems (ALUS) based on object-based Normalized Difference Vegetation Index (NDVI) time series analysis. The approach consists of two main steps. First, to obtain relatively homogeneous land units in terms of phenological patterns, a principal component analysis (PCA) is applied to an annual MODIS NDVI time series, and an automatic segmentation is performed on the resulting high-order principal component images. Second, the resulting land units are classified into the crop agriculture domain or the livestock domain based on their land-cover characteristics. The crop agriculture domain land units are further classified into different cropping systems based on the correspondence of their NDVI temporal profiles with the phenological patterns associated with the cropping systems of the study area. A map of the main ALUS of the Brazilian state of Tocantins was produced for the 2013-2014 growing season with the new approach, and a significant coherence was observed between the spatial distribution of the cropping systems in the final ALUS map and in a reference map extracted from the official agricultural statistics of the Brazilian Institute of Geography and Statistics (IBGE). This study shows the potential of remote sensing techniques to provide valuable baseline spatial information for supporting agricultural monitoring and for large-scale land-use systems analysis.

Published
2017

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