Search

Multiple sclerosis (MS) is a neuroinflammatory disease that significantly impacts young women, often leading to disability. Teriflunomide – an FDA-approved and once-daily oral disease-modifying therapy (DMT) – serves as a first-line treatment for relapsing-remitting multiple sclerosis (RRMS). Observational studies on the efficacy and outcomes of teriflunomide in Iranian patients, particularly in female-only cohorts, remain scarce. In this study, we present the findings from a cohort of female RRMS patients treated with Tebazio – the latest teriflunomide brand in Iran, manufactured by Zistdaru Danesh Corporation since 2018. This was a single-center case study involving a cohort of female RRMS patients registered at the Isfahan MS Center in Isfahan, Iran. Patients who were initiated on Tebazio (14 mg once daily) were enrolled at the start of their treatment and subsequently followed for at least 18 months. We included female patients who were either beyond child-bearing age or not planning for pregnancy in the foreseeable future and instructed them to use at least two effective contraception methods. Throughout the follow-up period, we collected subjects' background, clinical and paraclinical data through in-person interviews, neurological examinations, and standardized checklists. The data were then analyzed using SPSS version 26. We enrolled 49 female RRMS patients with a mean age of 44.97 ± 8.83 years and a mean disease duration of 112.83 ± 12.31 months. Two of our subjects (4%) were eventually lost to follow-up (none due to adverse effects or disease progression). Among the 47 patients who completed the follow-up, only five (10.6%) experienced a relapse, and seven (14.9%) developed new T2-weighted lesions on their final brain MRI. We also observed a significant reduction in the mean Expanded Disability Status Scale (EDSS) scores, from 1.53 ± 0.61 at the initial visit to 1.39 ± 0.57 at the final follow-up visit (P-value = 0.001). The most frequent side effects of Tebazio were hair thinning in 68.1% (n=32), GI upset in 36.1% (n=17), and elevated LFT in 29.8% (n=14) of the patients. Additionally, no cases of life-threatening adverse effects (malignancies or progressive leukoencephalopathy) were reported. Tebazio demonstrates robust safety and efficacy in Iranian female RRMS patients of child-bearing age who are not considering pregnancy. The therapy shows low relapse rates, minimal disease progression, and manageable side effects, supporting its role as a viable treatment option. [ABSTRACT FROM AUTHOR]

Statement of the Problem: The use of a new antimicrobial combination in the regenerative endodontic treatment of immature teeth pulp necrosis is a well-known method. Concerns have been raised about the destructive effect of this combination on the stem cells from the apical papilla of permanent human teeth, and there is a study gap. Purpose: The main objective of the present study was to investigate the cytotoxic effect of modified triple antibiotic paste (mTAP) on stem cells from the apical papilla (SCAPs) of permanent human teeth. Materials and Method: In this in vitro study, stem cells were removed from the immature teeth. After cultivation and third passage, metronidazole, ciprofloxacin, minocycline, and clindamycin were placed in the cell culture medium alone, paired, and in combinations as triple antibiotic paste (TAP) (metronidazole, ciprofloxacin, and minocycline) and mTAP (metronidazole, ciprofloxacin, clindamycin) with doses of 25, 50, 100, 200, 400μg/ml. After 1 and 3 days, cell viability in the culture medium was assessed using the MTT method ([4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide). SPSS software version 24, descriptive statistics methods, and statistical tests such as Kruskal-Wallis and Mann-Whitney tests were adopted to analyze the data. Results: Analysis of MTT findings indicated that the use of mTAP at 100μg/ml and TAP at 200μg/ml had no adverse cytotoxic effect on stem cells in the first 24 hours, compared to the control group. The cell viability decreased at higher concentrations, although it was not statistically significant. After 72 hours, the toxicity of concentrations higher than 100μg/ml of mTAP and 400 μg/ml of TAP significantly mitigated the percentage of viable cells. Conclusion: The obtained results demonstrated that the concentration of 100 μg/ml of mTAP could replace TAP in regenerative endodontic treatments at the studied time intervals without worrying about the toxicity. [ABSTRACT FROM AUTHOR]

Background: The Covid19 pandemic has reignited debates and discussions around healthcare systems' biosecurity vulnerabilities and cast a spotlight on the potential weaponization of biological agents. Terrorist and violent extremist groups have already attempted to incite the intentional spread of Covid19 and to use it as an improvised form of a biological weapon. This study aims to provide an epidemiological description of all terrorism-related attacks using biological agents sustained between 1970 and 2019.Methods: Data collection was performed using a retrospective database search through the Global Terrorism Database (GTD). The GTD was searched using the internal database search functions for all events using biological weapons between January 1, 1970 - December 31, 2019.Results: 33 terrorist attacks involving biological agents were recorded between 1970 and 2019, registering 9 deaths and 806 injuries. 21 events occurred in the United States, 3 in Kenya, 2 each in both the United Kingdom and Pakistan and a single event in Japan, Columbia, Israel, Russia and Tunisia.Conclusion: The reported use of biological agents as a terrorist weapon is extremely rare and accounts for 0.02% of all historic terrorist attacks. Despite its apparent rarity, however, bioterrorism has the ability to inflict mass injuries unmatched by conventional weapons. Anthrax has been the most commonly used in previous bioterrorism events with the vast majority of reported attacks occurring in the United States by a single suspected perpetrator. Counter-Terrorism Medicine (CTM) and Disaster Medicine (DM) specialists need to be proactive in delivering ongoing educational sessions on biological events to first responder communities, and anticipate emerging novel biotechnology threats. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of this systematic review was to evaluate the existing randomized controlled trials (RCTs) on the safety and efficacy of vital pulp therapy (VPT) and to analyze the outcomes of VPT performed with a variety of pulp-capping materials and techniques. MEDLINE (PubMed), Embase, Cochrane Library, and gray literature were searched (January 2000–March 2021). Study selection and data extraction were performed in duplicate. Eligible RCTs were critically appraised for risk of bias and quality of evidence and were meta-analyzed to estimate the treatment effects. Fourteen studies were included. The pooled success rate of VPT using contemporary capping materials such as mineral trioxide aggregate (MTA) or calcium silicate–based materials (CSMs) was 93.2% (95% confidence interval [CI], 91.6%–94.9%). Multiple subgroup analyses by different etiologies, procedure types, developmental stages of teeth, and preoperative diagnoses were performed. Analyses presented low certainty of evidence. No significant difference was noted between MTA and CSM at 12 months or a longer follow-up (risk ratio = 0.99; 95% CI, 0.95–1.03) with low certainty of evidence. Laser-assisted VPT failed to show significantly better outcomes than conventional VPT (risk ratio = 1.19; 95% CI, 0.99–1.49) with very low certainty of evidence. When MTA or CSM was used as a capping material, VPT was 93% successful. The techniques, etiologies, developmental stages of teeth, and preoperative diagnosis had no significant influence on treatment outcomes. No major adverse effects (except discoloration associated with the use of MTA) were identified. The overall quality of evidence was low. [ABSTRACT FROM AUTHOR]

The acute (symptomatic) apical abscess is characterized by pulp necrosis, rapid onset, spontaneous pain, percussion pain, pus formation, and tissue swelling. The etiopathology of acute apical abscesses includes active (lytic) herpesviruses and gram-negative anaerobic bacteria. The present study examined the potential of valacyclovir, an anti-herpesvirus agent, and systemic amoxicillin to manage the pain of acute apical abscesses. Twenty emergency patients with moderate to severe apical abscess pain received randomly either amoxicillin (1 g immediate dose followed by 500 mg, 4 times a day, totally 7 days) + valacyclovir (2 g immediate dose followed by 500 mg, twice a day, totally 3 days) ("valacyclovir" group, 10 patients) OR amoxicillin (1 g immediate dose followed by 500 mg, 4 times a day, totally 7 days) + placebo ("placebo" group, 10 patients). Daily telephone calls during the 6-day follow-up period assessed pain level on a numeric rating scale and analgesic intake. The Mann-Whitney and the Friedman statistical tests analyzed the outcome data. At the baseline examination, all 10 valacyclovir and 9 placebo patients exhibited moderate to severe pain and 18 patients needed pain medication. On the first day after baseline, the valacyclovir group showed 2 patients with moderate/severe pain and 1 patient on pain medication, but the placebo group revealed as many as 8 patients with moderate/severe pain and 9 patients on pain medication. The difference in pain level and analgesic usage between the valacyclovir and the placebo group remained statistically significant during the entire post-baseline study period (P <.05). The present study points to valacyclovir as a promising adjunctive agent in pain control with acute apical abscesses. [ABSTRACT FROM AUTHOR]

The aim of this investigation was to evaluate the clinical and histological differences in wound healing between beveled and perpendicular vertical releasing incisions in dogs. Four male mongrel dogs were used in this investigation. In each quadrant, a vertical releasing incision was made on either the mesial or the distal aspect of the cuspid teeth of each animal all on the same day. The sites were randomly selected to either receive a beveled incision or a perpendicular incision. A sulcular muco-periosteal flap was raised, reapproximated, and then sutured using 3-0 Vicryl. The animals were evaluated daily for the first week, and then at different time intervals during this investigation. One animal was killed at each time interval of 9, 14, 21, and 28 days after surgery. One animal was killed at each time interval, and a bone block consisting of the cuspid teeth and their surrounding bone and soft tissues was harvested, formalin fixed, and paraffin embedded. Samples were sectioned serially and stained with hematoxylin-eosin. Specimens were evaluated using a microscope with magnification ranging from ×10 to ×400 by a histopathologist. Four indices were used for histologic evaluation. At day 9 after surgery, a visible groove was seen in the marginal tissues of both perpendicular and beveled incisions. At day 9, both of the histologic sections showed less organized connective tissue and capillary networks with no significant difference in inflammation. In the 14-day samples, a depression was still present at the perpendicular incision sites, but not in the beveled incision group, where the groove was not visualized at all. In the 21- and 28-day samples, irregular capillary arrangements were seen in the connective tissue of the perpendicular incision groups with completely healed epithelium. There were no statistically significant differences noted histologically between the beveled and perpendicular incision groups noted at 9, 14, 21, or 28 days (P >.05). Based on these findings, it appears that clinical and histologic healing of beveled or perpendicular releasing incisions are similar 28 days after surgery. [ABSTRACT FROM AUTHOR]

Children in the intensive care unit experience a high level of pain and anxiety. This study aimed to reveal the health care providers experience of non-pharmacological pain and anxiety management and its barriers in the pediatric intensive care unit. This qualitative-descriptive study was conducted with thirteen nurses and five physicians in the pediatric intensive care unit in Iran. Individual, in-depth and semi-structured interviews were conducted, which were analyzed by conventional content analysis. Five main categories were identified from data analysis: 1) The importance of parents' presence, 2) Disturbance in the presence of parents and communication during the COVID-19 pandemic, 3) Choosing non-pharmacological approaches according to the child's interests and conditions, 4) Building trust in the child through non-pharmacological interventions 5) Barriers to non-pharmacological pain and anxiety management in the pediatric intensive care unit. Health care providers implement some non-pharmacological methods to manage pain and anxiety in the pediatric intensive care unit. Facilitating the open presence of parents, using innovative methods to communicate with children, and training and psychological support for nurses and parents, especially during the COVID-19 pandemic are recommended. [ABSTRACT FROM AUTHOR]

Earthquake is a random natural phenomenon, which can occur at any time and location in a given seismic zone with any magnitude. The earthquake vulnerability in buildings and urban infrastructures is a key issue for crisis management. Therefore, an assessment model should be developed to identify and prioritize the significant seismic risks involved. In risk management, several numerical and descriptive phrases are used for risk identification and assessment. These phrases are estimative by nature and the accuracy of the estimations is vital in future decision-making in risk management. Fuzzy sets are a reliable tool in solving such problems and result in high level of accuracy through creating multiple-value logical models. The purpose of this study is to identify and prioritize the major risks associated with earthquakes in urban worn-out textures through the Delphi survey technique and fuzzy sets approach. The experts' opinions were collected using a fuzzy Delphi questionnaire with a five-point Likert scale of measurement method. Participants in the Delphi panel consist of 15 experts in the field of engineering. Important risks were determined and prioritized in the two phases of fuzzy Delphi method. According to the results, among the 19 identified major risks, road blockage and flood with defuzzification values of 0.917 and 0.583, respectively, have the highest and lowest risk potential respectively in Jalili Neighborhood's worn-out textures. It is expected that, because of the simplicity and the high accuracy for identification of the most vulnerable parts, this study provides scientific and useful guidance to urban managers and planners in decision-making and adopting the most appropriate strategies for mitigating damages and potential risks of earthquakes in urban worn-out textures. [ABSTRACT FROM AUTHOR]

Despite numerous viral outbreaks in the last decade, including a devastating global pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas systems have the potential to address these critical needs in the response against infectious disease. Initially discovered as the bacterial adaptive immune system, these systems provide a unique opportunity to create programmable, sequence-specific technologies for detection of viral nucleic acids and inhibition of viral replication. This review summarizes how CRISPR-Cas systems—in particular the recently discovered DNA-targeting Cas12 and RNA-targeting Cas13, both possessing a unique trans -cleavage activity—are being harnessed for viral diagnostics and therapies. We further highlight the numerous technologies whose development has accelerated in response to the COVID-19 pandemic. In this review, Freije et al. describe the ways CRISPR-Cas systems have been harnessed for the detection and inhibition of mammalian viruses. They focus on Cas12- and Cas13-based detection technologies, including those developed in response to the COVID-19 pandemic and studies of Cas9 and Cas13's antiviral activity. [ABSTRACT FROM AUTHOR]

Regenerative endodontic procedures are undertaken on permanent teeth with necrotic pulps and open apices in an attempt to resolve symptoms, to allow the continued development of the root(s), and to reestablish vitality. The available histologic analysis of these teeth has, in the majority of studies, shown that true regeneration of the pulp-dentin complex is not achieved. A recent investigation using an animal model outlined a procedure wherein pulpal amputation a few millimeters short of the apex followed by evoked bleeding allowed the complete regeneration of the normal pulp-dentin complex in immature vital teeth of ferrets. By implementation of this procedure, we report successful pulp regeneration outcome evidenced by continued root development and a positive response to pulp vitality tests in a maxillary central incisor with an open apex diagnosed with symptomatic irreversible pulpitis. [ABSTRACT FROM AUTHOR]

This systematic review and meta-analysis aimed to evaluate the clinical and radiographic failure of nonsurgical endodontic treatment and retreatment for mature permanent teeth with or without apical periodontitis using the single-cone (SC) obturation technique with calcium silicate-based bio-ceramic (CSBC) sealers and to compare these failure rates to other sealer materials and obturation techniques. A comprehensive search was conducted using MEDLINE (PubMed), Embase, Cochrane Library, Scopus, Web of Science, and gray literature up to March 2023. Two reviewers assessed the eligibility of the included studies. Eligible studies were critically appraised for risk of bias and quality of evidence. Subsequently, a meta-analysis of pooled data was conducted utilizing the RevMan software (P <.05) to evaluate the failure rate of non-surgical root canal therapy using CSBC sealers and SC obturation procedures. Separately, another analysis was conducted to compare those results with the outcome of nonsurgical root canal therapy using alternative obturation materials and methods. Five studies were included. The pooled failure rate for nonsurgical endodontic treatment and retreatment combined using CSBC sealers and SC obturation technique was 6.8% [95% confidence interval (CI) = (3%–12%), I2 = 46%]. A second analysis was conducted on the 3 included clinical trials to compare the outcomes of the intervention (CSBC sealers and SC obturation technique) and control groups (other sealers and other obturation techniques). This analysis found no significant difference between the 2 groups regarding clinical and radiographic failure of endodontic treatment and retreatment [Risk ratio = 0.71, 95% CI = (0.33, 1.51), I2 = 0]. This difference was also not statistically significant when the failure rate of primary root canal treatment and retreatment were separately analyzed [Combined Risk ratio of primary root canal treatment = 0.94, 95% CI = (0.46, 1.93), I2 = 0%; Combined Risk ratio of retreatment = 0.21, 95% CI = (0.001, 75.46), I2 = 0%]. The overall results of this systematic review and meta-analysis demonstrate that the SC obturation technique with CSBC sealer provides similar results compared to other obturation materials and techniques in facilitating the healing of apical periodontitis. [ABSTRACT FROM AUTHOR]

SDSI+AmpSeq: A DNA spike-in tool to track samples and detect key modes of error in SARS-CoV-2 genomic data Kim A. Lagerborg☨,1,2, Erica Normandin*,☨,1,3, Matthew R. Bauer☨,1,2, Gordon Adams1, Katherine Figueroa1, Christine Loreth1, Adrianne Gladden-Young1, Bennett Shaw1,4, Leah R. Pearlman1, Daniel Berenzy5, Hannah H Dewey5, Susan Kales5, Sabrina T. Dobbins1, Erica S. Shenoy4, David Hooper4, Virginia M. Pierce6,7,8, Kimon C. Zachary4,9,10, Daniel J. Park1, Bronwyn L. MacInnis1,11,12, Ryan Tewhey5,13,14, Jacob E. Lemieux1,4, Pardis C. Sabeti ⟊,1,3,11,12,15, Steven K Reilly *,⟊,1,3, Katherine J. Siddle⟊,1,3. ☨,⟊ denote equal contribution. *denotes corresponding author., The global spread and continued evolution of SARS-CoV-2 has driven an unprecedented surge in viral genomic surveillance. Amplicon-based sequencing methods provide a sensitive, low-cost and rapid approach but suffer a high potential for contamination, which can undermine laboratory processes and results. This challenge will only increase with expanding global production of sequences by diverse laboratories for epidemiological and clinical interpretation, as well in genomic surveillance in future outbreaks. We present SDSI+AmpSeq, an approach which uses synthetic DNA spike-ins (SDSIs) to track samples and detect inter-sample contamination through the sequencing workflow. Applying SDSIs to the ARTIC Consortium’s amplicon design, we demonstrate their utility and efficiency in a real-time investigation of a suspected hospital cluster of SARS-CoV-2 cases and across thousands of diagnostic samples at multiple laboratories. We establish that SDSI+AmpSeq provides increased confidence in genomic data by detecting and in some cases correcting for relatively common, yet previously unobserved modes of error without impacting genome recovery., Author's Original

Urgent actions are imperative to assess ambient BTEX concentration in urban areas and increase awareness of the significant health risks linked to exposure to these volatile compounds. This study examines the spatiotemporal variations of BTEX concentration in BRT stations and provides a health risk assessment in Tabriz, located in the northwest of Iran. We collected samples repeatedly from four BRT stations and three areas between stations (N = 86). The mixture BTEX compounds had average concentrations ranging from 6.7 to 52.9 μg/m3, with the highest concentration belonging to o-xylene. Additionally, the average ratios of toluene/benzene, m-xylene/benzene, and o-xylene/benzene were 2.4, 2.3, and 3.0, respectively. Total BTEX concentrations were significantly higher in BRT stations than areas between stations. Furthermore, the concentration of total BTEX doubled in the evening compared to the morning. Although the maximum concentrations of BTEX were recorded in winter, there were no significant seasonal differences. The lifetime cancer risk (LCR) of benzene exposure was 1.07 × 10−7 and 1.52 × 10−5 for passengers and residents located in the vicinity of the BRT lane, respectively. In conclusion, this study suggests that emissions from BRT buses are one of the main contributors to BTEX in Tabriz. • BTEX concentrations were significantly higher in BRT stations than in-between stations. • Total BTEX concentration doubled in the evening compared to the morning. • Total BTEX levels were only marginally higher in winter than summer. • The LCR for individuals located near the BRT lane exceeded the EPA-recommended value. [ABSTRACT FROM AUTHOR]

Highlights • We found no associations between patients' mean anti-HSV2 antibody index and the diagnosis of NMO or MS. • There was no significant difference in mean anti-HSV2 antibody O.D./index between control group and MS or NMO group. • We found no associations between NMO and MS patients' demographic and clinical features and their mean anti-HSV2 antibody index/O.D. Abstract Background Multiple sclerosis (MS) and neuromyelitis optica (NMO) are demyelinating disorders of the central nervous system. There is growing evidence that viruses may play a causal role in these diseases. Human herpes viruses have been of special attention since their DNA have been detected in many of MS patients' samples. Human herpes simplex virus 2 (HSV-2) is a member of this family which has not been investigated thoroughly in MS and NMO. Methods We took blood samples from 90 subjects including 30 RRMS patients, 30 NMO patients and 30 healthy controls. After serum isolation, all serum samples were frozen at −70°C to be used for enzyme linked immunosorbent assay (ELISA) for detection of specific antibodies against HSV-2. Presence or absence of antibodies against HSV-2 was determined based on the cut-off calibrator and index values were then determined. A value of <0.9: negative, between 0.9 and 1.1: equivocal and <1.1: positive. Results Mean age of all subjects was 33.36 and female to male ratio was 4.3/1. None of the subjects were seropositive for anti-HSV-2 antibody. Analysis indicated no significant differences (P -value >0.05) among antibody levels between MS (0.19 ± 0.08), NMO (0.22 ±0.16) and control (0.21 ±0.09) groups. There were also no correlations between mean antibody index or O.D. and subjects' sex, family history, blood group, smoking history, age and presence of visual-motor-sensory or other forms of disability in any of the three MS, NMO and control groups (P -value >0.05). Conclusion We found no associations between patients' diagnosis of MS or NMO and mean anti-HSV-2 antibody index and O.D. levels. [ABSTRACT FROM AUTHOR]

Background: Several lines of research support associations between sleep and cognition in older adults. However, there is a paucity of data regarding sleep and cognition in nonagenarians and centenarians.Aims: The current study examined self-reported sleep quantity and sleep quality in relation to hippocampal volume and cognition in adults aged 90 and older.Methods: A total of 144 participants of The 90+ Study completed The Medical Outcomes Study sleep questionnaire. Participants reported subjective sleep duration in hours and three sleep quality factors: sleep problems, adequacy, and somnolence. Neuropsychological assessments of memory, global cognition, language, and executive function were completed, on average, 61 days from the questionnaire. Hippocampal volume on 3 T MRI, adjusted for intracranial volume, was obtained in 82 participants. We performed multiple linear regressions, controlling for age, sex, education, sleep medication, and depression, to examine sleep characteristics in relation to hippocampal volume and cognitive performance in all the subjects and then stratified by cognition.Results: Sleep duration > 8 h was associated with lower scores in tests of global cognition, memory, and executive function compared to sleep duration of 7-8 h when collapsing across cognitive status, but only with memory in cognitively impaired subjects, and not in cognitively normal subjects.Conclusions and discussion: Long-sleep duration is associated with poorer global cognition, memory, and executive function in the oldest-old, and is only associated with memory in cognitively impaired oldest-old. Additional research is necessary to determine if sleep duration is a risk factor or a result of poor cognition in advanced age. [ABSTRACT FROM AUTHOR]

Introduction The susceptibility of endodontically treated teeth (ETT) to fracture is mainly associated with the loss of tooth structure. This study evaluated the effect of the access cavity design and taper preparation of root canals on ETT fracture resistance of maxillary molars. Methods For tapering assessment, 30 sound distobuccal roots of maxillary molars were randomly assigned to 1 of 3 groups ( n = 10): a .04 taper, a .06 taper, or a .08 taper. Endodontic canal preparations were performed using the Twisted Files rotary system (Kerr Co, Glendora, CA). In addition, 48 intact maxillary first and second molars were randomly assigned to 1 of 3 groups ( n = 16) for cavity preparation approaches: intact teeth, traditional access cavity (TAC), or conservative access cavity (CAC). Fracture resistance was tested using a universal testing machine. For statistical analysis, the level of significance was P ≤ .05. Results The .04 taper instrumentation had the highest fracture resistance (259.61 ± 52.06), and the .08 taper had the lowest (168.43 ± 59.63). The .04 and .06 groups did not differ significantly ( P > .05); however, these groups differed significantly from the .08 group ( P ≤ .05). Regarding the cavity preparation approaches, the 3 groups of intact teeth, CAC, and TAC showed fracture resistance mean values of 2118.85 ± 336.97, 1705.69 ± 591.51, and 1471.11 ± 435.34, respectively, with no significant difference between the CAC and TAC groups ( P > .05). Conclusions Increasing the taper of the root canal preparation can reduce fracture resistance. Moreover, access cavity preparation can reduce resistance; however, CAC in comparison with TAC had no significant impact. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Meningiomas without dural attachments are quite a novelty, with such meningiomas in the posterior fossa being even more far and few between. The authors describe an extremely rare cerebellopontine angle (CPA) meningioma lacking a dural attachment arising from the choroid plexus of the foramen of Luschka (CPFOL). A 35-year-old male presented to our center complaining of a generalized and progressive headache for 10 months. A 3 cm × 4 cm well-defined lesion in the left CPA, hypointense in T1 and hyperintense in T2-weighted magnetic resonance imaging (MRI), was noted with no evident dural base or dural attachment. CPFOL was appreciated right at the point where the tumoral base was detected, which implied that the tumor originated from CPFOL. A gross total resection (GTR) was achieved, with the postoperative period remaining uneventful. The histopathologic investigation confirmed a transitional meningioma World Health Organization (WHO) grade I with no atypical features. Meningioma without dural attachment remains a rare phenomenon, with few available in English literature, and such pathology in the posterior fossa is even more unusual. Discriminating between CPFOL and another kind of CPA meningioma is mandatory when dealing with intracranial meningioma surgeries. While managing a space-occupying lesion around CPA, although extremely rare, a meningioma originating from CPFOL is suggested to be included in the differentials with necessary imaging analysis and advised to be imperatively pursued before proceeding for surgical intervention. • Meningiomas arising from the choroid plexus of the foramen of Luschka and located in the CPA without dural attachment is an infrequent entity. • The CPA-located tumors possess specific differential diagnosis, which, in turn, demands an exceptional therapeutic plan. • Cerebellopontine angle meningioma originating from choroid plexus of the foramen of Luschka without dural base or dural attachment remains an extremely rare entity. [ABSTRACT FROM AUTHOR]