YAP1Rearrangement in Parotid Sclerosing Mucoepidermoid Carcinoma

ABSTRACTObjectiveThis study investigates to investigate Yes-associated protein 1 (YAP1) rearrangement status in a six-case of sclerosing mucoepidermoid carcinoma (SMEC) series with reference to 20 conventional mucoepidermoid carcinomas.MethodA retrospective analysis was conducted on a cohort of patients diagnosed with SMEC from 2018 to 2022. The presence of YAP1rearrangement was determined using fluorescence in situ hybridization (FISH) analysis targeting the YAP1gene located at 11q22.1-q22.2. Clinical data, including patient outcomes, were collected and analyzed. Next-generation sequencing (NGS) was performed to identify the fusion partner involved in the YAP1rearrangement.ResultsA total of six cases of SMEC were included in the study, of YAP1::MAML2fusion was detected and five cases showed YAP1rearrangement on FISH testing.ConclusionYAP1alteration may explain the indolent nature of SMECs, especially in cases with low cellularity. Further studies incorporating NGS analysis are warranted to unravel the fusion partner associated with YAP1rearrangement, providing a deeper understanding of the molecular mechanisms underlying the positive outcomes observed in these patients.