201. Teratogenic effect of Carbamazepine use during pregnancy in the mice.
- Author
-
Elshama SS, Osman HE, and El-Kenawy Ael-M
- Subjects
- Abnormalities, Drug-Induced pathology, Animals, Female, Fetal Growth Retardation chemically induced, Fetal Growth Retardation pathology, Fetal Weight drug effects, Fetus abnormalities, Forelimb abnormalities, Forelimb drug effects, Gestational Age, Hindlimb abnormalities, Hindlimb drug effects, Mice, Nervous System drug effects, Nervous System pathology, Nervous System Malformations chemically induced, Nervous System Malformations pathology, Pregnancy, Risk Assessment, Abnormalities, Drug-Induced etiology, Anticonvulsants toxicity, Carbamazepine toxicity, Fetus drug effects, Teratogens toxicity
- Abstract
Carbamazepine use is the first choice of antiepileptic drugs among epileptic pregnant females. There are many inconclusive studies regard the safety of carbamazepine use during pregnancy. This study aims to investigate the morphological and histopathological teratogenic effects of carbamazepine use during pregnancy. The healthy pregnant females mice divided into equal five groups (each n=20). The first (control) group received distilled water/day. Second, third, fourth and fifth group received 8.75, 22.75, 52.5, 65 mg of carbamazepine/day respectively. Carbamazepine and water were given by gastric gavage throughout gestational period. Fetuses were delivered on the 18th day of gestation by hysterectomy. Fetal measurements and appearance were assessed with investigation the histopathological changes of brain and spinal cord. There was a significant decrease of weight, different organs weight, length, upper and lower limb length of mice in the first day of delivery in fifth group. There was a significant increase of weight, different organs weight, length, upper and lower limb length in the third group. Many congenital anomalies such as spina bifida, meromelia, microphalmia, oligodactyly, anencephaly, neurodegeneration of brain and spinal cord were noticedin fifth group. Teratogenic effect of carbamazepine represented as growth retardation and neurodevelopmental toxicity depending on its overdose degree.
- Published
- 2015