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Proliferation and differentiation of neural stem cells irradiated with X-rays in logarithmic growth phase.
- Source :
-
Neuroscience research [Neurosci Res] 2012 Jul; Vol. 73 (3), pp. 263-8. Date of Electronic Publication: 2012 Apr 24. - Publication Year :
- 2012
-
Abstract
- Exposure of the fetal brain to ionizing radiation causes congenital brain abnormalities. Normal brain formation requires regionally and temporally appropriate proliferation and differentiation of neural stem cells (NSCs) into neurons and glia. Here, we investigated the effects of X-irradiation on proliferating homogenous NSCs prepared from mouse ES cells. Cells irradiated with X-rays at a dose of 1Gy maintained the capabilities for proliferation and differentiation but stopped proliferation temporarily. In contrast, the cells ceased proliferation following irradiation at a dose of >5Gy. These results suggest that irradiation of the fetal brain at relatively low doses may cause congenital brain abnormalities as with relatively high doses.<br /> (Copyright © 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.)
- Subjects :
- Animals
Cell Differentiation physiology
Cell Line
Female
Mice
Nervous System Malformations etiology
Nervous System Malformations pathology
Neural Stem Cells metabolism
Neurogenesis physiology
Neurogenesis radiation effects
Pregnancy
Prenatal Exposure Delayed Effects physiopathology
Radiation Injuries, Experimental physiopathology
X-Rays adverse effects
Cell Differentiation radiation effects
Cell Proliferation radiation effects
Neural Stem Cells pathology
Neural Stem Cells radiation effects
Pregnancy, Animal radiation effects
Prenatal Exposure Delayed Effects pathology
Radiation Injuries, Experimental pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8111
- Volume :
- 73
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neuroscience research
- Publication Type :
- Academic Journal
- Accession number :
- 22561132
- Full Text :
- https://doi.org/10.1016/j.neures.2012.04.005