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A compressed video bitstream can be partitioned according to the coding priority of the data, allowing prioritized wireless communication or selective dropping in a congested channel. Known as data partitioning in the H.264/Advanced Video Coding (AVC) codec, this paper introduces a further sub-partition of one of the H.264/AVC codec’s three data-partitions. Results show a 5 dB improvement in Peak Signal-to-Noise Ratio (PSNR) through this innovation. In particular, the data partition containing intra-coded residuals is sub-divided into data from: those macroblocks (MBs) naturally intra-coded, and those MBs forcibly inserted for non-periodic intra-refresh. Interactive user-to-user video streaming can benefit, as then HTTP adaptive streaming is inappropriate and the High Efficiency Video Coding (HEVC) codec is too energy demanding.

The metabolism of hepcidin is profoundly modified in chronic kidney disease (CKD). We investigated its relation to iron disorders, inflammation and hemoglobin (Hb) level in 199 non-dialyzed, non-transplanted patients with CKD stages 1-5. All had their glomerular filtration rate measured by 51Cr-EDTA renal clearance (mGFR), as well as measurements of iron markers including hepcidin and of erythropoietin (EPO). Hepcidin varied from 0.2 to 193 ng/mL. The median increased from 23.3 ng/mL [8.8-28.7] to 36.1 ng/mL [14.1-92.3] when mGFR decreased from ≥60 to

In our case, a 45-year-old male patient had multiple fractures accompanied by hypophosphatemia. FGF-23 levels were significantly increased, and total body magnetic resonance imaging (MRI) revealed a tumor mass located at the distal tibia leading to the diagnosis of tumor-induced osteomalacia (TIO). After resection of the tumor, hypophosphatemia and the increased levels of FGF-23 normalized within a few days. Subsequent microscopic examination and immunohistochemical analysis revealed a phosphaturic mesenchymal tumor mixed connective tissue variant (PMTMCT) showing a positive expression of somatostatin receptor 2A (SSTR2A), CD68, and Periostin. Electron microscopy demonstrated a poorly differentiated mesenchymal tumor with a multifocal giant cell component and evidence of neurosecretory-granules. However, the resected margins showed no tumor-free tissue, and therefore a subsequent postoperative radiotherapy was performed. The patient is still in complete remission after 34 months. Tumor resection of PMTMCTs is the therapy of choice. Subsequent radiotherapy in case of incompletely resected tumors can be an important option to avoid recurrence or metastasis even though this occurs rarely. The prognostic value of expression of Periostin has to be evaluated more precisely in a larger series of patients with TIO.

BACKGROUND:Little is known about muscle mass loss in early stage chronic kidney disease (CKD). We used 24-hour urinary creatinine excretion rate to assess determinants of muscle mass and its evolution with kidney function decline. We also described the range of urinary creatinine concentration in this population. METHODS:We included 1072 men and 537 women with non-dialysis CKD stages 1 to 5, all of them with repeated measurements of glomerular filtration rate (mGFR) by (51)Cr-EDTA renal clearance and several nutritional markers. In those with stage 1 to 4 at baseline, we used a mixed model to study factors associated with urinary creatinine excretion rate and its change over time. RESULTS:Baseline mean urinary creatinine excretion decreased from 15.3 ± 3.1 to 12.1 ± 3.3 mmol/24 h (0.20 ± 0.03 to 0.15 ± 0.04 mmol/kg/24 h) in men, with mGFR falling from ≥ 60 to

BACKGROUND: Iron disorders are common and complex in chronic kidney disease (CKD). We sought to determine whether a 3-marker index would improve the classification of iron disorders in CKD anaemia. METHODS: We studied the association between Hb level and iron indexes combining 2 or 3 of the following markers: serum ferritin (

The Endocuff is a device mounted on the tip of the colonoscope to help flatten the colonic folds during withdrawal. This study aimed to compare the adenoma detection rates between Endocuff-assisted (EC) colonoscopy and standard colonoscopy (SC).This randomized prospective multicenter trial was conducted at four academic endoscopy units in Germany.500 patients (235 males, median age 64[IQR 54-73]) for colon adenoma detection purposes were included in the study. All patients were either allocated to EC or SC. The primary outcome measure was the determination of the adenoma detection rates (ADR).The ADR significantly increased with the use of the Endocuff compared to standard colonoscopy (35.4%[95% confidence interval{CI} 29-41%] vs. 20.7%[95%CI 15-26%], p

The puppet film Cybernetic Grandmother (1962) by Jiří Trnka with music by Jan Novák represents an example of a critical attitude towards basic premises of cybernetics widely consumed in Czechoslovakia in 1960s after publishing the translation of Norbert Wiener's seminal work. Novák in cooperation with Trnka provides here a certain deconstruction of cybernetic mythology by its own truest means.

INTRODUCTION: Even though renal function decline is considered relentless in chronic kidney disease (CKD), improvement has been shown in patients with hypertensive nephropathy. Whether this can occur in any type of nephropathy and at any stage is unknown as are the features of patients who improve. METHODS: We identified 406 patients in the NephroTest cohort with glomerular filtration rates (mGFR) measured by (51)Cr-EDTA clearance at least 3 times during at least 2 years of follow-up. Individual examination of mGFR trajectories by 4 independent nephrologists classified patients as improvers, defined as those showing a sustained mGFR increase, or nonimprovers. Twelve patients with erratic trajectories were excluded. Baseline data were compared between improvers and nonimprovers, as was the number of recommended therapeutic targets achieved over time (specifically, for systolic and diastolic blood pressure, proteinuria, and use of renin angiotensin system blockers). RESULTS: Measured GFR improved over time in 62 patients (15.3%). Their median mGFR slope was +1.88[IQR 1.38, 3.55] ml/min/year; it was -2.23[-3.9, -0.91] for the 332 nonimprovers. Improvers had various nephropathies, but not diabetic glomerulopathy or polycystic kidney disease. They did not differ from nonimprovers for age, sex, cardiovascular history, or CKD stage, but their urinary albumin excretion rate was lower. Improvers achieved significantly more recommended therapeutic targets (2.74±0.87) than nonimprovers (2.44±0.80, p

String quartets by Jan Novák (1921–1984) as a whole has not yet been processed either practically or theoretically. This year, Ištvan Quartet decided to make a complete recording. This event gave us the opportunity to completely overlook and analyze the available scores, which were previously owned by the family of the composer. These are compositions created in large span of composer's life in years 1945–1978. Some cycles are apparently closed (String Quartet of 1946, Three inventions for string quartet, Quadricinium Fidium) for certain we are not sure of their finality (String Quartet "Jiří Trnka", The two-movement string quartet). In general, we can state use of rational (neoclassical) style with elements of jazz and in quartets created in the 60s years, the use of serial techniques. In the late period there is a distinguishable influence of Leoš Janáček's string quartets.

Digital Subscriber Line (DSL) network access is subject to error bursts, which, for interactive video, can introduce unacceptable latencies if video packets need to be re-sent. If the video packets are protected against errors with Forward Error Correction (FEC), calculation of the application-layer channel codes themselves may also introduce additional latency. This paper proposes Low-Density Generator Matrix (LDGM) codes rather than other popular codes because they are more suitable for interactive video streaming, not only for their computational simplicity but also for their licensing advantage. The paper demonstrates that a reduction of up to 4 dB in video distortion is achievable with LDGM Application Layer (AL) FEC. In addition, an extension to the LDGM scheme is demonstrated, which works by rearranging the columns of the parity check matrix so as to make it even more resilient to burst errors. Telemedicine and video conferencing are typical target applications.

Bystromite (MgSb2O6) nanorods were prepared using a colloidal method in the presence of ethylenediamine, after a calcination step at 800 °C in static air. From X-ray powder diffraction analyses, a trirutile-type structure with lattice parameters a = 4.64 Å and c = 9.25 Å and space group P42/mnm was identified. Using scanning electron microscopy (SEM), microrods with sizes from 0.2 to 1.6 μm were observed. Transmission electron microscopy (TEM) analyses revealed that the nanorods had a length of ~86 nm and a diameter ~23.8 nm. The gas-sensing properties of these nanostructures were tested using pellets elaborated with powders of the MgSb2O6 oxide (calcined at 800 °C) at temperatures 23, 150, 200, 250 and 300 °C. The pellets were exposed to different concentrations of carbon monoxide (CO) and propane (C3H8) at these temperatures. The results showed that the MgSb2O6 nanorods possess excellent stability and high sensitivity in these atmospheres.

Broadband wireless technology, though aimed at video services, also poses a potential threat to video services, as wireless channels are prone to error bursts. In this paper, an adaptive, application-layer Forward Error Correction (FEC) scheme protects H.264/AVC data-partitioned video. Data partitioning is the division of a compressed video stream into partitions of differing decoding importance. The paper determines whether equal error protection (EEP) through FEC of all partition types or unequal error protection (UEP) of the more important partition type is preferable. The paper finds that, though UEP offers a small reduction in bitrate, if EEP is employed, there are significant gains (several dBs) in video quality. Overhead from using EEP rather than UEP was found to be around 1% of the overall bitrate. Given that data partitioning already reduces errors through packet size reduction and differentiation of coding data, EEP with data partitioning is a practical means of protecting user-based video streaming. The gain from employing EEP is shown to be higher quality video to the user, which will result in a greater take-up of video services. The results have implications for other forms of prioritized video streaming.

Parasitic flatworms are responsible for serious infectious diseases that affect humans as well as livestock animals in vast regions of the world. Yet, the drug armamentarium available for treatment of these infections is limited: praziquantel is the single drug currently available for 200 million people infected with Schistosoma spp. and there is justified concern about emergence of drug resistance. Thioredoxin glutathione reductase (TGR) is an essential core enzyme for redox homeostasis in flatworm parasites. In this work, we searched for flatworm TGR inhibitors testing compounds belonging to various families known to inhibit thioredoxin reductase or TGR and also additional electrophilic compounds. Several furoxans and one thiadiazole potently inhibited TGRs from both classes of parasitic flatworms: cestoda (tapeworms) and trematoda (flukes), while several benzofuroxans and a quinoxaline moderately inhibited TGRs. Remarkably, five active compounds from diverse families possessed a phenylsulfonyl group, strongly suggesting that this moiety is a new pharmacophore. The most active inhibitors were further characterized and displayed slow and nearly irreversible binding to TGR. These compounds efficiently killed Echinococcus granulosus larval worms and Fasciola hepatica newly excysted juveniles in vitro at a 20 µM concentration. Our results support the concept that the redox metabolism of flatworm parasites is precarious and particularly susceptible to destabilization, show that furoxans can be used to target both flukes and tapeworms, and identified phenylsulfonyl as a new drug-hit moiety for both classes of flatworm parasites.

Rheumatoid arthritis- (RA-) associated interstitial lung disease (RA-ILD) is the extra-articular complication with most adverse impact on the quality of life and survival in RA patients. However, treatment options are limited and controlled studies are lacking. Here, we present the case of a 66-year-old patient suffering from severe RA-ILD, which has been successfully treated with Rituximab (RTX). After failure of conventional DMARD therapy, our patient showed sustained improvement of clinical pulmonary parameters as well as joint inflammation following B-cell depletion with RTX. The six-minute-walk test improved from 380 meters to 536 meters and the forced vital capacity from 2.49 liters to 3.49. The disease activity score could be reduced from 7.7 to 2.8. Therefore, RTX might be considered as an alternative treatment for RA-ILD in patients not responding to conventional DMARD therapy.

This paper presents a prioritization scheme based on an analysis of the impact on objective video quality when dropping individual slices from coded video streams. It is shown that giving higher-priority classified packets preference in accessing the wireless media results in considerable quality gain (up to 3 dB in tests) over the case when no prioritization is applied. The proposed scheme is demonstrated for an IEEE 802.11e quality-of-service- (QoS-) enabled wireless LAN. Though more complex prioritization systems are possible, the proposed scheme is crafted for mobile interactive or user-to-user video services and is simply implemented within the Main or the Baseline profiles of an H.264 codec.

The Glass Bead Game, a novel written by Hermann Hesse is understandable on many levels. It disserts on the spiritual and intellectual world constructed by universities and their principal representatives. In the broadest sense it deals with the possibility of existence of small elite groups keeping and fostering the noble Glass Bead Game. In more detailed view the game is something very hermetical and artificial, crossing borders of particular arts and sciences. Under very similar perspective can be seen the game played by rules of the New Music. Dodecaphony and row techniques became for a certain period the main expressive tool for the czech exile composer Jan Novák (1921–1984).

Tumor biomarkers provide a quantitative tool for following tumor progression and response to therapy. However, investigations of clinically useful tumor biomarkers are time-consuming, costly, and limited by patient and tumor heterogeneity. In addition, assessment of biomarkers as indicators of therapy response is confounded by the concomitant use of multiple therapeutic interventions. Herein we report our use of a clinically relevant orthotopic animal model of malignant pleural mesothelioma for investigating tumor biomarkers. Utilizing multi-modality imaging with correlative histopathology, we demonstrate the utility and accuracy of the mouse model in investigating tumor biomarkers--serum soluble mesothelin-related peptide (SMRP) and osteopontin (OPN). This model revealed percentage change in SMRP level to be an accurate biomarker of tumor progression and therapeutic response--a finding consistent with recent clinical studies. This in vivo platform demonstrates the advantages of a validated mouse model for the timely and cost-effective acceleration of human biomarker translational research.

An immortality of the production of the Moravian composer Jan Novák (1921–1984) should have been provided by the connection to the Latin language and literature. Novák not only set in music verses of Latin humanists and classics, but he also translated into Latin, composed poetry and he was also the author of the paper Musica poetica Latina. There is perhaps no precedent for such a writing in the twentieth century. It is a practical guide for setting Latin texts in music, including the theory of metrical poetry, classical Latin pronunciation, etc. In my paper I have tried to compare the Novák's attempt with two disproportionately more famous writings on the topic: Horatio's De Arte Poetica and Musica Poetica by Joachim Burmeister.

The impossibility of return is a significant feature of the production of artists in exile. Analogous to Bohuslav Martinů, Jan Novák became a composer in exile owing to the political situation in Czechoslovakia. Just one year before the communist putsch in 1948, Novák studied with Aaron Copland and Bohuslav Martinů in Tanglewood and in New York. The principles of free thought and creation outside prescribed limits became integral to his personality. In 1968, after twenty years of confronting political obstacles, Jan Novák decided to return to the free world. Nevertheless he did not return to the USA. In 1984 Rafael Kubelík planned to perform Novák's cantata Dido in New York with the composer in the role of narrator, but an injury sustained by the conductor prevented any performance within Novák's lifetime. Dido was finally performed by the New York Philharmonic in 1986, two years after Jan Novák's death; but he was never to return either to the USA or to the country of his birth for the recognition that was his due.

The cestode Echinococcus granulosus, the agent of hydatidosis/echinococcosis, is remarkably well adapted to its definitive host. However, the molecular mechanisms underlying the successful establishment of larval worms (protoscoleces) in the dog duodenum are unknown. With the aim of identifying molecules participating in the E. granulosus-dog cross-talk, we surveyed the transcriptomes of protoscoleces and protoscoleces treated with pepsin at pH 2. This analysis identified a multigene family of secreted monodomain Kunitz proteins associated mostly with pepsin/H(+)-treated worms, suggesting that they play a role at the onset of infection. We present the relevant molecular features of eight members of the E. granulosus Kunitz family (EgKU-1 - EgKU-8). Although diverse, the family includes three pairs of close paralogs (EgKU-1/EgKU-4; EgKU-3/EgKU-8; EgKU-6/EgKU-7), which would be the products of recent gene duplications. In addition, we describe the purification of EgKU-1 and EgKU-8 from larval worms, and provide data indicating that some members of the family (notably, EgKU-3 and EgKU-8) are secreted by protoscoleces. Detailed kinetic studies with native EgKU-1 and EgKU-8 highlighted their functional diversity. Like most monodomain Kunitz proteins, EgKU-8 behaved as a slow, tight-binding inhibitor of serine proteases, with global inhibition constants (K(I) (*)) versus trypsins in the picomolar range. In sharp contrast, EgKU-1 did not inhibit any of the assayed peptidases. Interestingly, molecular modeling revealed structural elements associated with activity in Kunitz cation-channel blockers. We propose that this family of inhibitors has the potential to act at the E. granulosus-dog interface and interfere with host physiological processes at the initial stages of infection.

Packet-level Forward Error Control (FEC) for video streaming over a wireless network has received comparatively limited investigation, because of the delay introduced by the need to assemble a group of packets. However, packet-level interleaving when combined with FEC presents a remedy to time-correlated error bursts, though it can further increase delay if this issue is not addressed. This paper proposes adapting the overall degree of interleaved packet-level FEC according to the display deadlines of packets, transmit buffer occupation, and estimated video input to the wireless channel, all of which address the issue of delay. To guard against estimation error, the scheme applies a conservative adaptation policy, which accounts for picture type importance to ensure that display deadlines are met, thus avoiding this defect of interleaving. The paper additionally introduces a greedy algorithm that effectively groups packet-level FEC protection according to packet priority. Priority encoding adds extra protection during deep fades. As feedback is not required, the interleaving scheme is suitable for all forms of video broadcast. A Bluetooth piconet demonstrates the packet-level FEC interleaving scheme, which provides higher quality delivered video compared to the industry-standard Pro-MPEG Cop#3r2 interleaving scheme.