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Objective: to evaluate the efficacy of a single or double administration of a preparation of high molecular weight hyaluronic acid (HLA) with chondroitin sulfate (CS) in post-traumatic knee osteoarthritis (OA). Material and methods. The study included 91 patients with stage III post-traumatic knee OA. All patients received intra-articular (i/a) injection of high molecular weight HLA with CS; 36 patients received the drug once (group 1) and 55 twice (group 2) with an average interval of 7±2 days. Before the start of treatment and 2 weeks, 1, 3, 6 and 12 months after i/a injection of HLA, pain intensity at rest and during movement was assessed using a visual analogue scale (VAS) and function was assessed using KOOS questionnaire (Knee injury and Osteoarthritis Outcome Score). Results and discussion. In general, patients receiving single and double i/a injections of HLA, pain during movement at baseline, and after 2 weeks, 1, 3, 6 and 12 months was 6.7±1.1; 4.0±0.7; 4.3±0.8; 4.6±1.0; 4.5±1.1 and 5.3±0.4 cm; pain at rest – 2.7±0.6; 1.5±0.2; 1.8±0.2; 2.1±0.5; 2.2±0.3 and 2.6±0.2 cm, and KOOS score was 35.9±13.6; 43.5±13.6; 49.2±17.6; 57.0±12.5; 51.5±11.7 and 40.3±10.2, respectively. In group 1, pain during movement at the same time line reached 6.7±1.2; 4.0±0.7; 4.3±1.1; 4.6±.08; 4.5±0.6 and 5.3±1.3 cm; pain at rest – 2.7±0.5; 1.5±0.3; 1.8±0.4; 2.1±0.4; 2.2±0.6 and 2.6±0.6 cm; KOOS score – 37.2±8.7; 39.1±10.1; 43.0±12.3; 47.0±13.6; 49.5±14.7 and 35.7±12.4, respectively.In the 2nd group, pain during movement was 6.1±1.5; 3.3±0.7; 3.6±0.6; 3.4±0.5; 3.7±0.4 and 4.4±0.3 cm; pain at rest was 2.6±0.3; 1.9±0.2; 1.1±0.2; 0.9±0.1; 0.7±0.1 and 1.7±0.3 cm; KOOS score was 34.7±9.4; 47.1±11.1; 59.3±11.5; 61.4±12.7; 57.2±14.3 and 45.7±12.4, respectively. Conclusion. In patients with stage III knee OA, double injections of HLA with HS were more effective. The maximum pain reduction and functional improvement were observed in the first 3 months after local injection therapy.

Invasion and metastasis are important hallmarks of lung cancer, and affect patients’ survival. Early diagnostics of metastatic potential are important for treatment management. Recent findings suggest that the transition to an invasive phenotype causes changes in the expression of 700–800 genes. In this context, the biomarkers restricted to the specific type of cancer, like lung cancer, are often overlooked. Some well-known protein biomarkers correlate with the progression of the disease and the immunogenicity of the tumor. Most of these biomarkers are not exclusive to lung cancer because of their significant role in tumorigenesis. The dysregulation of others does not necessarily indicate cell invasiveness, as they play an active role in cell division. Clinical studies of lung cancer use protein biomarkers to assess the invasiveness of cancer cells for therapeutic purposes. However, there is still a need to discover new biomarkers for lung cancer. In the future, minimally invasive techniques, such as blood or saliva analyses, may be sufficient for this purpose. Many researchers suggest unconventional biomarkers, like circulating nucleic acids, exosomal proteins, and autoantibodies. This review paper aims to discuss the advantages and limitations of protein biomarkers of invasiveness in lung cancer, to assess their prognostic value, and propose novel biomarker candidates.

Synthesis and study on structure and properties of organic-inorganic composites based on epoxy resin, CuO and Fe3O4 absorbing light in infrared part of spectrum was performed. The composites synthesis was performed by introduction of CuO and Fe3O4 micropowders into liquid epoxy composition with subsequent homogenization of the mixture and polymerization. The study on structure and properties of organic-inorganic composites was performed by methods of optical microscopy, infrared and visible spectroscopy, study on microhardness. According to the IR spectroscopy data, introduction of oxide particles leads to decrease in epoxy polymer degree of calcification. The composites containing Fe3O4 show relatively low light reflection until 4.2 % in the spectral range of 1000–1100 nm that corresponds to the theoretical estimation data. Incorporation of CuO and Fe3O4 micropowders into the epoxy polymer leads to an increase in microhardness from 120 to 160 MPa. Obtained experimental data can serve as the base for development of IR-absorbing organic-inorganic composites for laser technology.

Efficient second harmonic generation and broad-band photoluminescence from deeply subwavelength and nontoxic nanoparticles is essential for nanophotonic applications. Here, we explore nonlinear optical response from mesoporous Si/SiO2, SiO2, and Si nanoparticles, considering various fabrication and treatment procedures. We show that thermal annealing (including femtosecond laser treatment) of mesoporous Si/SiO2 nanoparticles provides the transformation of Si phase from amorphous to crystalline, enhancing the second harmonic and nonlinear photoluminescent response. Notably, the SiO2 mesoporous frame of the considered Si/SiO2 nanoparticles plays a dual positive role for the nonlinear process: it stabilizes the Si material, and SiO2:OH− material has a second-order nonlinearity itself and impacts to the observed second harmonic signal.

Professor Alexander M. Seagal (1887–1968), was one of the first Russian cardiologists to identify cardiac arrhythmias as a separate independent problem in cardiology. In addition to numerous works on various issues of therapy and cardiology, he is the author of apparently the first Russian monograph on arrhythmology, "Rhythms of Cardiac Activity and Their Disorders," entirely devoted to cardiac arrhythmias and which went through two editions in Soviet times (1935 and 1958). An analysis of the mechanisms of not only pathological rhythms, but also physiological ones was carried out, an original clinical and electrocardiographic classification of bradycardias ("neurogenic" and "myogenic") and paroxysmal tachycardias was given, the electrophysiological and pathohistological basis of arrhythmias known at that time and methods of their treatment were analyzed. The book shows variants of arrhythmias that are still rare today ("cardiac alternation", etc.), and describes clinical variants of paroxysmal tachycardias, including atypical ones — induced by allergic triggers. In all cases of clinical examples, not only the clinical description and ECG picture of the arrhythmia are provided, but also the necessary therapeutic measures and prognosis. The clinic of arrhythmogenic syncope and other arrhythmic symptoms, which are still relevant in our time, is analyzed. Being a famous music connoisseur, A. M. Seagal used an original approach to recording the tones and rhythms of the heart, using a musical staff. Many clinical observations and conclusions are interesting and relevant in our time. A. M. Seagal was undoubtedly the one who stood at the origins of Russian arrhythmology, as a separate direction in cardiology.

Background. Reducing malignant mortality to 185 cases per 100,000 by 2030 is one of goals of the state program “Healthcare development” in Russia.Aim. To assess potential impact of using trastuzumab deruxtecan in patients with breast cancer on reducing cancer mortality.Materials and methods. Three indications of trastuzumab deruxtecan were considered: adult patients with HER2-positive unresectable or metastatic breast cancer that were previously treated with trastuzumab and a taxane in the advanced or metastatic setting (referred as “Second line”); adult patients with HER2-positive unresectable or metastatic breast cancer who previously received at least two lines of therapy in the metastatic setting including trastuzumab emtansine (referred as “Third line”); adult patients with HER2-low metastatic breast cancer who had received one or two previous lines of chemotherapy (referred as “HER2-low metastatic breast cancer”). The set of comparators for each clinical situation was formed based on the clinical guidelines and clinical trials of trastuzumab deruxtecan. Overall survival and treatment duration were modelled on the clinical trials basis. The model was used to estimate number of lives saved in case of transitioning all eligible patients to trastuzumab deruxtecan within a three-year horizon.Results. Up to 3,609 patients p. a. in the “Second line” situation, 1,300 patients p. a. in the “Third line” situation and 2,260 patients p. a. in the “HER2-low breast cancer” situation can initiate trastuzumab deruxtecan treatment. In that case mortality from neoplasms could be reduced by 1,461 deaths in case of “Second line”, by 427 deaths in case of “Third line” and by 801 deaths in case of “HER2-low metastatic breast cancer” over three years. Reduction in mortality will contribute to achieving the target mortality rate from neoplasms of 21.61–24.81 %, 4.31–12.57 % and 5.91–20.89 %, respectively.Conclusion. Using trastuzumab deruxtecan for breast cancer treatment in different clinical situations leads to quantitate reduction in cancer mortality in Russia.

Second harmonic generation is a non-linear optical phenomenon in which coherent radiation with frequency ω interacts with a non-centrosymmetric material and produces coherent radiation at frequency 2ω. Owing to the exciting physical phenomena that take place during the non-linear optical excitation at the nanoscale, there is currently extensive research in the non-linear optical responses of nanomaterials, particularly in low-dimensional materials. Here, we review recent advancements in the polarization-resolved second harmonic generation propertied from atomically thin two-dimensional (2D) crystals and present a unified theoretical framework to account for their nonlinear optical response. Two major classes of 2D materials are particularly investigated, namely metal chalcogenides and perovskites. The first attempts to tune and control the second harmonic generation properties of such materials via the application of specific nanophotonic schemes are additionally demonstrated and discussed. Besides presenting recent advances in the field, this work also delineates existing limitations and highlights emerging possibilities and future prospects in this field.

The problem of testing sandwich specimens with composite facing layers and a transversally soft core for four-point bending was formulated. The localized external load from the loading rollers to the facing layer of the specimen was assumed to be transmitted through composite tabs, which reduced the stress concentration in the compressed facing layer. The external facing layers and tabs were analyzed for deformation mechanics using S.P. Timoshenko’s kinematic model. The model considered compression in the facing layers but not in the tabs. The core was classified as transversally soft with zero tangential stresses. The tabs were connected to the facing layers through adhesive interlayers, and the displacement vectors of the front surfaces of the tabs were coupled kinematically with the displacement vectors of the front surfaces of the facing layers. The relationships between the transverse shear stresses and strain in the facing layers were assumed to be physically nonlinear, with the shear modulus being a function of the shear strain.Using the generalized variational principle of virtual displacements, a system of nonlinear differential equilibrium equations for the facing layers and tabs was derived. The system was closed by three more equations, which were the conditions for the kinematic coupling of the facing layers with the core based on tangential displacements. To numerically solve the formulated problem, the finite sum method, also known as the method of integrating matrices, was employed. This method involved reducing the original boundary value problem to integro-algebraic equations with Volterra-type operators of the second kind and additional relations for determining the unknown integration constants. The algorithm of the developed method was implemented as an application software, which facilitated a series of computational experiments. The results obtained were compared with the experimental data on the four-point bending of sandwich specimens with the facing layers made of a unidirectional fiber-reinforced composite characterized by specific geometric and physico-mechanical properties, as well as with tabs under the loading rollers. It was shown that the use of tabs significantly increases the ultimate compressive failure stresses in the facing layers.

Abstract Background Among the non-traditional antibacterial agents in development, only a few targets critical Gram-negative bacteria such as carbapenem-resistant Pseudomonas aeruginosa, Acinetobacter baumannii or cephalosporin-resistant Enterobacteriaceae. Endolysins and their genetically modified versions meet the World Health Organization criteria for innovation, have a novel mode of antibacterial action, no known bacterial cross-resistance, and are being intensively studied for application against Gram-negative pathogens. Methods The study presents a multidisciplinary approach, including genetic engineering of LysECD7-SMAP and production of recombinant endolysin, its analysis by crystal structure solution following molecular dynamics simulations and evaluation of antibacterial properties. Two types of antimicrobial dosage forms were formulated, resulting in lyophilized powder for injection and hydroxyethylcellulose gel for topical administration. Their efficacy was estimated in the treatment of sepsis, and pneumonia models in BALB/c mice, diabetes-associated wound infection in the leptin receptor-deficient db/db mice and infected burn wounds in rats. Results In this work, we investigate the application strategies of the engineered endolysin LysECD7-SMAP and its dosage forms evaluated in preclinical studies. The catalytic domain of the enzyme shares the conserved structure of endopeptidases containing a putative antimicrobial peptide at the C-terminus of polypeptide chain. The activity of endolysins has been demonstrated against a range of pathogens, such as Klebsiella pneumoniae, A. baumannii, P. aeruginosa, Staphylococcus haemolyticus, Achromobacter spp, Burkholderia cepacia complex and Haemophylus influenzae, including those with multidrug resistance. The efficacy of candidate dosage forms has been confirmed in in vivo studies. Some aspects of the interaction of LysECD7-SMAP with cell wall molecular targets are also discussed. Conclusions Our studies demonstrate the potential of LysECD7-SMAP therapeutics for the systemic or topical treatment of infectious diseases caused by susceptible Gram-negative bacterial species and are critical to proceed LysECD7-SMAP-based antimicrobials trials to advanced stages.

Abstract Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive eye disease. GDLD is characterized by the loss of barrier function in corneal epithelial cells (CECs) and amyloid deposition due to pathogenic variants in the TACSTD2 gene. Limbal stem cell transplantation (LSCT) has been suggested as an effective therapeutic alternative for patients with GDLD. However, despite LSCT, amyloid deposition recurs in some patients. The pathogenesis of recurrence is poorly studied. We present the case of a patient with GDLD. Genetic analysis revealed a homozygous deletion, NM_002353.3:c.653del, in the TACSTD2 gene. Functional analysis in a cell model system revealed the loss of the transmembrane domain and subcellular protein mislocalization. The patient with GDLD underwent direct allogeneic LSCT with epithelial debridement followed by deep anterior lamellar keratoplasty 10 months later due to amyloid deposition and deterioration of vision. Taken together, the results of transcriptome analysis and immunofluorescence staining of post-LSCT corneal sample with amyloid deposits obtained during keratoplasty demonstrated complete restoration of wild-type TACSTD2 expression, indicating that donor CECs replaced host CECs. Our study provides experimental evidence that amyloid deposition can recur after LSCT despite complete restoration of wild-type TACSTD2 expression.

This article describes the study of attention concentration in children using a new method — the ATTON test for the first time. The duration of the test, the response rate, the number of errors and correct answers in the main (106 children) and control (108 children) groups were measured. The authors identified differences in the groups in test duration, response rate, number of errors and correctly completed tasks at the significance level α

Aim of the study was to analyze the frequency and dynamics of schizophrenia, schizotypal disorder and autism in children and adolescents in Moscow and in the Kabardino-Balkarian Republic (KBR) for 2021–2022 to determine the need for appropriate support measures for this population group. Material and methods. The dynamics of primary and general morbidity of mental diseases, including children and adolescents, as well as primary and general morbidity of schizophrenia (F20), schizotypal disorder (F21) and autism among children and adolescents in Moscow and in the KBR for 2021–2022, corresponding to the ICD-10 codes, are considered. Results and discussion. There is an increase in the overall incidence of mental illness in 2021 and 2022 both in Moscow (an increase of 8.4 %) and in the KBR (an increase of 0.3 %), of which among the child population (10.9 and 2.2 %, respectively). An enhancement of the primary incidence of mental illness in Moscow was revealed with an increase of 23.7 %, in the KBR with an increase of 1.1 %, among the child population corresponding values were 29.4 and 10.6 %. The overall incidence of schizophrenia decreased by 1.1 % in Moscow and by 0.5 % in the KBR, among the child population – by 1.3 and 21.3 %, respectively. The overall incidence of schizotypal disorder enhanced by 9.1 % in Moscow, by 8.1 % in the KBR, among the child population – by 7.9 and 0 %, respectively. A decrease in the primary incidence of schizophrenia was revealed by 0.1 % in Moscow, by 91 % in the KBR. Among the child population it increased by 25.6 % in Moscow and decreased by 100 % in the KBR, as well as number of newly diagnosed cases of schizophrenia. The primary incidence of schizotypal disorder rose by 34.1 % in Moscow, by 16.7 % in the KBR, among the child population it decreased by 1 % and hasn’t changed, respectively. It is possible to note an increase in the total incidence of autism in 2021–2022 both in Moscow (by 21.1 %) and in the KBR (by 9.4 %), while the number of newly diagnosed cases of autism in Moscow increased by 26.3 %, then in the CBD it decreased by 66.8 %. Conclusions. A diagnostic bias was revealed – a decrease in the number of patients diagnosed with schizophrenia (F20) and a significant increase in the number of patients diagnosed with schizotypal disorder (F21). The statistical data obtained mainly indicate an improvement in the diagnosis of autism in childhood in Moscow and a decrease in the incidence of autism in the KBR.

Background. The purpose is to investigate metal non-opaque foreign bodies of firearm origin. Materials and methods. Five cases of removing soft tissue foreign bodies of gunshot origin were investigated, when radiography of the limb soft tissues didn’t detect foreign bodies, but they were removed during the primary surgical wound debridement. X-ray of soft tissue gunshot wounds found no foreign bodies. To study radiographic density, foreign bodies were placed in a foam model with subsequent multislice computed tomography. For spectral analysis of metal foreign bodies, we used wavelengths unconventional for X-ray, which allowed to conduct X-ray fluorescence and X-ray structural studies. Results. Radiographic density of metal foreign bodies ranged from 989 to 2123 HU. Given the different thickness of foreign bodies, from 0.4 to 3.2 mm, the average was 1700 ± 189 HU. The foam had radiographic density of –969 HU with model dimensions of 200 × 100 × 50 mm. When examining samples of foreign bodies, it was found that they are deformed, have different thicknesses. One of the samples is light and smooth on one side, and dark and rough on the other. X-ray fluorescence results: composition on the light side (% by mass): Al — base, Mn — 0.8, Fe — 0.3, Zn — 0.1, Cr — 0.05, Ti — 0.2, corresponding to Al-Mn alloy. The dark side is an oxidized Al-Mn alloy. In the spectrum of the dark side of the sample, the Br-Kα line was detected, which indicates the participation of bromine compounds in the oxidation process. From the smooth side of the sample, the spectrum of this line is not determined. Conclusions. Non-opaque metal foreign bodies of gunshot origin are a rare phenomenon. Metal foreign bodies with low radiographic density are non-ferromagnetic, the use of modern magnetic surgical instruments will not be effective. Visualization of metal foreign bodies, which are not determined by radiography, is possible with the help of multislice computed tomography. The use of the wavelength of primary radiation, which is unconventional for X-ray spectral analysis, and original X-ray optical schemes allows for quantitative determination of the composition and structure of any metal foreign bodies.

Allogeneic tendon grafts are seriously demand in knee joint plastic surgery. The novel method of tendon cryopreservation, including sterilization with supercritical carbon dioxide, was developed in N.V. Sklifosovsky Research Institute for Emergency Cryopreserved tendons retain their normal fiber structure without significant loss of mechanical properties. At the next stage it was necessary to evaluate cryopreserved tendons′ integration inside bone canal in experimental animals.The aim of study. To evaluate morphologic changes of autologous and allogeneic tendons inside the femur in rats and to determine the effect of tendon transplantation on the physical activity.Material and methods. The study was conducted on white inbreed male rats. Three groups of animals were formed: the control group (animals without tendon transplantation), the 1st experimental group – animals with autologous tendon transplantation, the 2nd experimental group – animals with allogeneic tendon transplantation. In animals of the experimental groups the through channel was formed in the distal metaepiphysis of the femur and a tail tendon graft 0.5 x 0.1 cm was placed there. To assess the physical activity of the animals, we studied maximum distance that the animals could run 3 and 6 weeks after transplantation was determined, using treadmill test. The graft structure was evaluated on histological preparations in transmitted light, stained with hematoxylin-eosin and Van Gieson′s stain. To assess the preservation of collagen fibers we checked the autofluorescence intensity of collagen.Results. According to the treadmill test, the distance run by the animals of both experimental groups did not significantly differ from the values in the control group. Histological analysis after 3 weeks in both experimental groups revealed signs of fibers′ decomposition in the absence of inflammatory infiltration and maintaining close contact with bone trabeculae. The autofluorescence intensity of the collagen fibers in grafts corresponded to normal or was close to normal. After 6 weeks, the animals of both experimental groups revealed areas of graft fusion with their own bone, Sharpe fibers were actively formed. In both groups, numerous small vessels with diameters up to 10 microns were detected in the area of tendon-bone contact. Infiltration of grafts by inflammatory cells was absent or very insignificant, active migration of fibroblasts to the tendon area was also not observed. In both groups, tendon grafts had areas where fiber decompactization was observed. In the area of contact with the bone, the autofluorescence of tendon fibers was sharply increased, which indicates the chemical cleavage of collagen. At 3 and 6 weeks after transplantation the effect of fixation (integration) of the tendon with bone tissue was observed in both experimental groups.Conclusions. Allogeneic tendon grafts did not cause a pronounced inflammatory or immune reaction in experimental animals. 6 weeks after transplantation of autologous and allogeneic tendons, the integration of grafts inside the femoral canal was observed. Cryopreserved allogeneic tendons were able to integrate into the body's own tissues without pronounced structural and functional disorders. According to the treadmill test, the distance covered by the animals of both experimental groups did not differ statistically significantly from the values in the control group (without tendon transplantation) after 3 and 6 weeks

Objective: to evaluate differences in the expression of genes associated with β-oxidation and de novo synthesis of fatty acids (FAs) in the blood of patients with the late stage of knee osteoarthritis (OA) before total knee arthroplasty (TA) depending on the development of postoperative pain (POP) in order to determine the molecular mechanisms responsible for the development of chronic POP. Material and methods. Blood of 50 patients with stage III–IV knee OA complaining of constant pain and joint dysfunction was analyzed prior to TA. The control group consisted of 26 healthy individuals. Pain intensity was assessed using a visual analogue scale (VAS) and the BPI questionnaire. In addition, pain, stiffness and physical functioning were assessed using WOMAC index and the presence of neuropathic pain was assessed using the DN4 and PainDETECT questionnaires. The development of POP was assessed 3 and 6 months after TA. Total RNA isolated from blood was used to determine the expression of ACLY, ACC1, MLYCD, FASN and CPT1A genes by real-time quantitative reverse transcriptase-polymerase chain reaction. Results and discussion. POP ≥ 30 mm by VAS was detected in 17 patients. Before TA, the expression of most of the analyzed genes was significantly increased compared to controls, while the expression of the FASN gene was comparable in patients with OA and healthy individuals. There were no differences in clinical and functional parameters between the groups of patients with and without POP. Before surgery, patients who subsequently developed POP had significantly higher expression of ACLY and CPT1A genes than patients who were satisfied with the results of TA. At the same time, no differences in the expression of ACC1, MLYCD and FASN were found in the groups analyzed. Conclusion. The development of POP is associated with an increased supply of FAs to the mitochondria caused by overexpression of the CPT1A gene, as well as with the accumulation of acetyl-CoA, a product of high expression of the ACLY gene, which can be measured in the blood of OA patients before TA.

Local injection therapy (LIT) with hyaluronic acid (HA) medications is one of the most promising methods for the treatment of periarticular soft tissue pathology (PASTP) caused by injury or overuse. Objective: to evaluate the efficacy and safety of LIT with HA medication with a molecular weight of 500–730 kDa in patients with various post-traumatic PASTP. Material and methods. The study included 30 patients with rotator cuff syndrome (RCS), lateral epicondylitis (LE) and plantar fasciitis (PF) after trauma. Inclusion criteria were the presence of moderate/severe pain (≥40 mm on a visual analogue scale (VAS)) over a 3-month period and the absence of effect of LIT with glucocorticoids. All patients were administered HA peritendinously three times (7 days apart) under ultrasound guidance. Treatment results were evaluated after 1 and 3 months based on the dynamics of pain intensity (VAS) and functional indicators using the ASES (American Shoulder and Elbow Surgical Evaluation), MES (Mayo Elbow Score) and FFI (Foot Functional Index) questionnaires. Results and discussion. In the general group, there was a statistically significant decrease in pain intensity after 1 and 3 months from a mean of 57.6 ± 14.7 to 37.0 ± 14.8 and 35.0 ± 14.3 mm according to VAS respectively (p < 0.05). In the patient groups with different PASTP, the average assessment of pain intensity and functional impairment at baseline and after 1 and 3 months was: for RCS (n = 11) 59.0 ± 15.1, 39.0 ± 15.7, 36.3 ± 16.2 mm according to VAS and 49.1 ± 14.3, 60.1 ± 13.7, 61.7 ± 3.8 according to ASES, respectively; with LE (n = 10) 54.0 ± 13.4, 35.0 ± 9.7, 34.0 ± 11.7 mm according to VAS and 71.5 ± 11.1, 78.3 ± 9.0, 81.5 ± 8.3 according to MES; with PF (n = 9) 61.0 ± 16.5, 36.6 ± 19.3, 34.4 ± 15.8 mm according to VAS and 47.2 ± 22.8, 39.6 ± 39.7, 39.0 ± 29.9 according to FFI. None of the patients experienced any adverse events during treatment. Conclusion. HA medication with a molecular weight of 500–730 kDa showed good efficacy and safety in LIT of PASTP of the shoulder, elbow joint and foot. Further studies are needed to evaluate the possibility of a broad use of the drug for the treatment of PASTP in real clinical practice.

This article describes the experience of using the type I interferon inhibitor anifrolumab (AFM) in a patient with a torpid course of systemic lupus erythematosus. The reason for prescribing AFM was the need for a quick achievement of low disease activity due to a planned hip replacement. Dynamic observational data over a six-month period confirmed that AFM enables a rapid achievement of low disease activity without increasing the dose of glucocorticoids, significantly improve the patient's quality of life and even prepare them for major surgery without exacerbating the underlying process.

У роботі досліджується крайова двоточкова задача для систем лінійних диференціальних рівнянь у частинних похідних. Не для будь-якої системи існує коректна двоточкова крайова задача. Так, для рівняння $$\displaystyle\frac{\partial u(x_1,x_2,t)}{\partial t}=\displaystyle\frac{\partial u(x_1,x_2,t)}{\partial x_1}+i \frac{\partial u(x_1,x_2,t)}{\partial x_2}$$ не існує крайових умов виду $au(x_1,x_1,0)+bu(x_1,x_2,T)=\varphi(x_1,x_2)$, при яких ця крайова задача буде буде коректна в просторі Л.\,Шварца. У роботі з'ясовано умови для матриці системи, за яких існують коректні крайові задачі в просторі Л. Шварца, а також вказано вигляд ціх крайових умов. Так для систем з ермітовою матрицею крайова задача з умовами наступного виду $u(x,0)+u(x,T)=\varphi(x)$ завжди буде коректною в просторі Л. Шварца, а також в просторах функцій кінцевої гладкості степеневого зростання. Для систем з однією просторовою змінною доведено, що завжди існують коректні крайові задачі з умовою $u(x,0)+bu(x,T)=\varphi(x)$ з додатньою $b$. Крім того досліджуються параболічні крайові задачі, властивостью яких є збільшування гладкості розв'язків. З'ясовано, що при умові степеневого зростання модуля власних значень матриці системи (тобто $\mathop{\text{Re}}\lambda_j(s)|\geq c|s|^h-b$ з додатними $c$ і $h$) існують параболічні крайові задачі. Наведено приклади коректних та параболічних крайових задач. Аналогічні результати мають місце для лінійних диференціальних рівнянь у частинних похідних. В якості прикладу розглянуто рівняння Гельмгольця $$\displaystyle\frac{\partial^2 u(x,t)}{\partial t^2}+\Delta u(x,t)=k u(x,t)$$, яке не є коректним за Петровським, але для нього існує крайова задача, яка є параболічною. Для рівняння з однією просторовою змінною наведено достатні умови на рівняння другого порядку за часом, при яких існують параболічні крайові задачі.

The article presents the results of an analysis of snow cover pollution in different parts of the Kirovsky district of Saratov. A comparison of the obtained data with the 1992 indicators was carried out. The connection between transport hubs with the highest dust load values and an increase in the number of cars was determined. Current spatial and temporal trends in snow cover pollution have been identified. The fact was confirmed that the highest concentration of dust in the snow cover is detected in areas with high traffic load. Determining the relationship between the increase in dust load in the study areas and the increase in the number of cars over a period of 30 years confirms the significant impact of transport on the ecological state of the environment in urbanized areas.

Multi-agent transport systems represent a convergence of diverse technologies, with the Internet of Things (IoT) serving as a foundational enabler for data orchestration. IoT facilitates seamless integration across networks, devices, and infrastructure, heralding an era where connectivity transcends human-human interactions to encompass interactions between objects and systems. Within IoT-enabled transport ecosystems, physical components become sentient through embedded sensors, perpetually generating vast data streams capturing real-world dynamics. This data deluge holds profound potential for optimizing operations, enhancing efficiencies, and augmenting societal convenience. Harnessing these data insights is imperative for catalyzing economic and policy shifts towards sustainable mobility paradigms that harmonize growth and societal benefit. IoT integration presents opportunities for innovative business models and technological advancements reshaping the transportation landscape. The purpose is to formulate comprehensive proposals for improving the traffic flow management model of a modern agglomeration based on "live" data. The method and methodology of the work. The article used methods of induction, analysis, synthesis and abstraction; scientific and theoretical method; method of research and comparison. Results. The findings prove that sustainable development processes directly correlate with implementing transportation projects, exerting a multiplicative effect across related industries through optimized accessibility and logistics. Consequently, transport infrastructure quality improves from reduced operational costs, making adopting new sustainable transportation modes economically viable for the broader economy. Scope of application of the results. It is advisable to apply the results obtained in the field of public administration, economic entities of transport and logistics activities.

Nanoscaled YAG:V powders were synthesized using low-temperature polymer-salt method. A comparison of their structure with monocrystals structure was performed. Structure, morphology and chemical composition of materials were studied using XRD, SEM and energy-dispersive X-ray spectroscopy. Estimation of average sizes of nanocrystals and crystal cell parameters was performed based on XRD data. The results were compared with the results obtained earlier for YAG:V monocrystals. Nanopowders synthesized at 1000 °C consist from microscopic aggregates of YAG:V nanocrystals with average size of 43 nm and crystal structure characteristic for YAG monocrystals. It was found that V3+ incorporation and their substitution of aluminum ions leads to distortion of crystal cell. It was shown that this phenomenon is observed both in YAG:V monocrystals and nanopowders synthesized using low-temperature polymer-salt method. The infrared spectroscopy data shows the similarity of the monocrystal and nanopowders structure. Obtained powders can be applied for fabrication of light-absorbing optical ceramics and organo-inorganic composites.

The issue of creating a criteria base for the Hartmann–Sprenger pipe workflow based on a closed mathematical model is considered. On the basis of a closed mathematical model, the main parameters affecting the increase in the total temperature of the gas at the end of the dead-end cavity above the deceleration temperature of the incoming flow are recorded. Parameters with the same dimension are combined into one group so that only one dimensionless complex is obtained for all these quantities. Finding dimensionless complexes based on the modeling theory allowed us to determine the criteria base of the Hartmann–Sprenger pipe workflow.

The paper presents the results of studies of dust residues of snow cover within various climatic zones and copper deposits of the Ural region. Snow cover research is one of the methods for environmental assessment of territories. This concerns the study of dust residues from snow cover samples, as shown by the example of the territories of the Northern and Southern Urals at different stages of work on copper deposits. The initial stage of study and development is considered using the example of porphyry copper deposits in the Chelyabinsk region, where snow samples reveal organic matter in dust residues, typical birch seeds, a small amount of minerals at a low dust load (P ˂ 100 kg/day per km2). For the deposits of the Ivdel region (Northern Urals), the dust residues largely contain organic dust, fragments of ore minerals (pyrite, chalcopyrite) and minerals of volcanic rocks and metasomatic rocks. The maximum value of the dust load is set for the Novo-Shemurskoye deposit currently being developed. A study of dust residues in the zone of influence of the Karabash copper smelter (before its reconstruction) has shown that in some parts of the sanitary protection zone the level of snow cover pollution is very high with dust load values up to 12,633 kg/day per km2, which is determined primarily by the widespread use of crushed copper smelting slag. In general, the study of dust residues of snow cover provides information about both the ecological state of the territories and the mineral composition of the residues, which must be used for practical purposes.