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Landslide is a major disaster threatening the safety and orderly production of an open-pit mine, so slope stability evaluation is of great significance to the support and monitoring arrangement. Landslide susceptibility mapping (LSM) was widely used in landslide prediction. The former research focused on the algorisms to improve its accuracy, which is relatively complete and left little room for further improvement. In this paper, new factors, including RQD and numerical simulation (NS), are selected to solve the limitation of traditional LSM on the integrity and stress state of the slope. The RQD value was obtained by machine learning and converted into rasters by the ordinary Kriging interpolation method. The slope stress was calculated by the finite difference method and converted into raster data using a program written by Fish language. Based on the information value (INV) method, gradient boosting decision tree (GDBT) was used as the main algorism to generate the LSM-NS. Finally, because LSM-NS contains landslides that have already occurred and those in high susceptibility due to its stress state, commonly used validation methods such as AUROC could no longer be used. Multiple validation methods were applied, such as stress monitoring and UAV tilt photography. The result indicates that the stress increases with crack generating in the high susceptibility area of LSM-NS, where traditional LSM could not predict. Therefore, the addition of RQD and NS could further improve the accuracy using existing algorism. LSM-NS is recommended as the more suitable model for landslide susceptibility assessment in a small area due to its excellent accuracy and efficiency. [ABSTRACT FROM AUTHOR]

Objective A succession of cases have reported flares of adult-onset Still's disease (AOSD) after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), raising concerns. We aimed to investigate the impact of inactivated SARS-CoV-2 vaccines on disease activity in patients with AOSD. Methods We prospectively enrolled clinically inactive AOSD patients visiting the outpatient clinics of our department. The patients received SARS-CoV-2 vaccines (BBIBP-CorV, Sinopharm, Beijing, China) voluntarily. The occurrence of relapse in the participants was recorded during the follow-up period, and a propensity score matching (PSM) method was used to compare the relapse rates between vaccinated and unvaccinated patients. Localized and systemic symptoms were assessed in the vaccinated patients. Results A total of 122 patients with inactive AOSD were included, of which 49.2% (n  = 60) voluntarily received the inactivated SARS-CoV-2 vaccine. The relapse rate did not increase significantly in vaccinated patients in comparison with unvaccinated patients (after PSM: 6.8% vs 6.8%), and no relapse occurred within 1 month after vaccination. No obvious adverse reactions were reported in 75.0% of the participants, and none of the patients reported severe reactions. Conclusion Increased disease activity or relapse following vaccination with inactivated SARS–CoV-2 was rare in patients with inactive AOSD. Local and systemic adverse reactions were found to be mild and self-limiting. These safety profiles of inactivated SARS–CoV-2 vaccines in patients with AOSD may assist in eliminating vaccine hesitancy and increase the vaccination rate against SARS-CoV-2. [ABSTRACT FROM AUTHOR]

A thorough assessment of thermal properties in heterogeneous subsurface is necessary in design of low‐temperature borehole heat exchangers (BHEs). A distributed thermal response test (DTRT), which combines distributed temperature sensing (DTS) with a conventional thermal response test (TRT), was conducted in a U‐bend geothermal loop installed in an open borehole at the University of Illinois at Urbana‐Champaign to estimate thermal properties by analyzing the thermal response of different geologic materials while applying a constant heat input rate. Fiber‐optic cables in the DTRT were deployed both inside the U‐bend geothermal loop and in the center of the borehole to improve the accuracy of calculated heat‐loss rates and borehole temperature profile measurements. To assess the subsurface thermal conductivity during the heating phase of the DTRT, a single‐source model and a multi‐source model, both based on the infinite line source method, were developed using the borehole temperature data and temperatures inside and along the outside of the loop, separately. The two models returned similar thermal conductivity values. The multi‐source modeling has the advantage of predicting the thermal conductivity of heterogeneous geologic materials from borehole temperature profiles during the DTRT heating phase. In addition, based on the distributed thermal conductivity measured in the borehole, estimates were made for both radial thermal impacts and the rate of heat loss in the BHE. [ABSTRACT FROM AUTHOR]

Objective To explore whether inactivated coronavirus disease 2019 vaccine influences the profile of prothrombotic autoantibodies and induces thrombotic events in primary APS patients. Methods We enrolled 39 primary APS patients who received two doses of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (BBIBPCorV, Sinopharm, Beijing, China) voluntarily in this prospective cohort. Prothrombotic autoantibodies were determined before vaccination and 4 weeks after the second dose of vaccination. Thrombotic disorders were evaluated via hospital site visits and assessments. Results There was no significant difference in the presence of all 11 autoantibodies detected before and 4 weeks after vaccination: for aCL, IgG (14 vs 16, P  = 0.64), IgM (13 vs 19, P  = 0.34), IgA (2 vs 3, P  = 0.64); anti-β2GP1, IgG (12 vs 12, P  = 1.00), IgM (5 vs 8, P  = 0.36), IgA (4 vs 3, P  = 0.69); anti-PS/PT IgG (13 vs 16, P  = 0.48), IgM (17 vs 22, P  = 0.26); LAC (22 vs 28, P  = 0.16); aPF4-heparin (0 vs 0, P  = 1.00) and ANA (23 vs 26, P  = 0.48). Notably, the distribution of the aPL profile in the pre- and post-vaccination cohorts was not affected by SARS-CoV-2 vaccination: for patients with a low-risk aPL profile (11 vs 10, P  = 0.799) and patients with a high-risk aPL profile (28 vs 29, P  = 0.799), respectively. Furthermore, no case exhibited symptoms of the thrombotic disorder during a minimum follow-up period of 12 weeks. There was no adjustment to the ongoing treatment regimens following SARS-CoV-2 vaccination. Conclusion Inactivated SARS-CoV-2 vaccine does not influence the profile of anti-phospholipid antibodies and anti-PF4-heparin antibodies nor induces thrombotic events in primary APS patients. [ABSTRACT FROM AUTHOR]

Large perpendicular magnetic anisotropy energy (MAE) and flexible regulation of the magnitude and direction of MAE have great potential for application in information storage devices. Here, utilizing first-principles calculations, we investigated the magnetic properties of free and MgO(001) supported RumIrn clusters (RumIrn@MgO(m + n = 3)). The results indicate that the MAE of mixed clusters increases with the number of Ir atoms due to Ir having a strong coupling between the non-degenerate dxy and dx2−y2 states. The MAE of free Ir3 is −8.18 meV with the easy magnetization direction parallel to the x-axis, while the MAE of supported Ir3 on the MgO substrate increases by a factor of 2.6, and the easy magnetization axis of the structure is shifted to a direction perpendicular to the substrate surface. This change in MAE is due to the significant enhancement in the coupling between the non-degenerate dyz and dx2−y2 states near the Fermi level of Ir3 atoms. Moreover, Ir3@MgO possesses high thermodynamic stability. These results give a new method for manipulating MAE and the direction of easy magnetization, which has great potential for application in magnetic nanodevices. [ABSTRACT FROM AUTHOR]

Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by the persistent presence of antiphospholipid antibodies (aPL) and thrombotic or obstetric events. Given the heterogeneity of the clinical manifestations, it is likely that genetic and acquired factors are involved in the pathogenesis of APS. The inherited polymorphisms of the thrombophilic gene, including methylenetetrahydrofolate reductase (MTHFR) C677T, type 1 plasminogen activator inhibitor (PAI-1) 4G/5G, factor V Leiden (FVL) G1691A, prothrombin (PT) G20210A, antithrombin (AT), and fibrinogen (Fg) polymorphisms, were analyzed in 67 aPL(+) patients from the Chinese Han population, including 41 APS patients and 26 persistent aPL carriers. The MTHFR C677T genotypes of 105 healthy controls, and the PAI-1 4G/5G polymorphism of 120 healthy controls, from the Chinese Han population were acquired for this study. Both the MTHFR C677T genotype (χ2 = 10.67, p = 0.004) and C/T allele distribution (χ2 = 5.92, p = 0.019) between the aPL(+) patients and healthy controls were found to be significantly different. Furthermore, we observed that the patients with at least one T allele had a higher risk of arterial thrombosis (CT vs. CC, OR 11.00, p= 0.025; CT + TT vs. CC, OR 10.27, p = 0.018). The C677T mutation of MTHFR is a risk factor for arterial thrombosis in Chinese Han patients with APS. [ABSTRACT FROM AUTHOR]

The 1.2 MM TPY straight-run diesel hydrocracking of SINIOPEC Beijing Yanshan Company has a designed jet fuel yield of more than 50% . This units has been operating in a detente hydrocracking mode for a long time, because of the overall product structure adjustment and insufficient hydrogen. The device can flexibly adjust the reaction depth according to the jet fuel demand. Retain the same catalyst system, more than 30% of the LCO can be blended into the mixed feedstock oil, and the LCO can be digested to produce gasoline according to the hydrogen balance. Based on the calibration data, the normal operation data and the hydroupgrading data, the performance of the catalyst, process conditions, material balance, comprehensive energy consumption, product distribution and product quality are analyzed and compared. It can provide theoretical and practical basis for production operation and process optimization of similar units, and help other refining enterprises to reduce the ratio of diesel to gasoline and adj'ust the product structure of chemical transformation. [ABSTRACT FROM AUTHOR]