201. Role of Antigenic Stimulation in Cutaneous T-Cell Lymphomas.
- Author
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Gumina ME, Hooper MJ, Zhou XA, and Koralov SB
- Subjects
- Humans, Skin pathology, Skin Neoplasms pathology, Lymphoma, T-Cell, Cutaneous pathology
- Abstract
Cutaneous T-cell lymphoma (CTCL) involves a clonal expansion of malignant cells accumulating in the skin, a primary barrier site. CTCL has long been hypothesized to be caused or perpetuated by chronic antigen stimulation due to unknown exposures. These antigenic triggers, defined as any element that may cause activation of malignant T cells through TCR signaling, have been hypothesized to range from chemicals to microbes. This review covers current evidence supporting chemical and microbial stimuli that may act as antigenic triggers of CTCL and summarizes novel areas of investigation, in which the potential antigenicity of the exposure is still unknown., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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