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Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4 + T cells in cutaneous T-cell lymphoma.
- Source :
-
Oncoimmunology [Oncoimmunology] 2019 Jul 17; Vol. 8 (11), pp. e1641387. Date of Electronic Publication: 2019 Jul 17 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Staphylococcus aureus is implicated in disease progression in cutaneous T-cell lymphoma (CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well as primary malignant CD4 <superscript>+</superscript> T cells from Sézary syndrome patients are considerably more resistant to alpha-toxin-induced cell death than their non-malignant counterparts. Thus, in a subset of Sézary syndrome patients the ratio between malignant and non-malignant CD4 <superscript>+</superscript> T cells increases significantly following exposure to alpha-toxin. Whereas toxin-induced cell death is ADAM10 dependent in healthy CD4 <superscript>+</superscript> T cells, resistance to alpha-toxin in malignant T cells involves both downregulation of ADAM10 as well as other resistance mechanisms. In conclusion, we provide first evidence that Staphylococcus aureus derived alpha-toxin can tilt the balance between malignant and non-malignant CD4 <superscript>+</superscript> T cells in CTCL patients. Consequently, alpha-toxin may promote disease progression through positive selection of malignant CD4 <superscript>+</superscript> T cells, identifying alpha-toxin as a putative drug target in CTCL.<br /> (© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.)
Details
- Language :
- English
- ISSN :
- 2162-4011
- Volume :
- 8
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Oncoimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 31646088
- Full Text :
- https://doi.org/10.1080/2162402X.2019.1641387