Search

Your search keyword '"Hidemi, Ito"' showing total 484 results
Start Over Author "Hidemi, Ito"
484 results on '"Hidemi, Ito"'

201. Study of muons from ultrahigh energy cosmic ray air showers measured with the Telescope Array experiment

Author

S. Kitamura, Hidemi Ito, Kenta Yashiro, Eiji Kido, M. V. Kuznetsov, Kazuhiro Machida, Jyunsei Chiba, Dongsu Ryu, Y. Takagi, Douglas Bergman, Toshiyuki Nonaka, K. Nagasawa, Hideki Tanaka, Elliott Barcikowski, J. H. Kim, T. Goto, G. Furlich, Takaaki Ishii, Y. Omura, Keitaro Fujita, Dmitri Ivanov, Pierre Sokolsky, J. Ogura, Yasunori Saito, B. K. Shin, Igor Tkachev, D. C. Rodriguez, R. Sahara, M. Takeda, Shigehiro Nagataki, Keijiro Mukai, Yuichiro Tameda, John N. Matthews, Akimichi Taketa, Rasha Abbasi, H. Oda, K. Yamazaki, M. Yamamoto, L. M. Scott, Nobuyuki Sakurai, T. Suzawa, Y. Yoneda, N. Inoue, M. Ohnishi, Sergey Troitsky, J. Remington, Y. Hayashi, Inkyu Park, Federico R. Urban, S. Udo, C. C. H. Jui, Isaac Myers, Y. J. Kwon, Hideyuki Ohoka, K. Kawata, Ryota Onogi, Koichi Sekino, A. Di Matteo, K. H. Lee, S. B. Thomas, T.-A. Shibata, Naoaki Hayashida, Takayuki Tomida, Gordon Thomson, T. Matsuyama, S. Ozawa, R. Mayta, Hongsu Kim, Priti Shah, Tom Stroman, Robert Cady, Y. Zhezher, Grigory Rubtsov, Hideaki Shimodaira, Hyoming Jeong, Y. Takahashi, Mai Takamura, K. Kasahara, Y. Uchihori, Shoichi Kishigami, S. Yoshida, Naoto Sakaki, R. Azuma, Masaomi Ono, Tareq Abu-Zayyad, R. Yamane, Kiyoshi Tanaka, Motoki Hayashi, J. P. Lundquist, Shingo Kawana, William Hanlon, M. Allen, H. Kawai, T. Okuda, J. Yang, H. Tokuno, J. D. Smith, Daisuke Ikeda, S. R. Stratton, Tiffany Wong, R. Takeishi, T. Seki, Masaki Fukushima, Masato Takita, K. Martens, K. Tsutsumi, Peter Tinyakov, Samuel Blake, Shoichi Ogio, Zach Zundel, Fumiya Shibata, R. Ishimori, Toshitsugu Fujii, Oleg Kalashev, H. Yamaoka, Michiyuki Chikawa, Ryo Nakamura, Kazuo Saito, H. Yoshii, Heungsu Shin, Toru Nakamura, K. Hibino, Kenichi Kadota, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, K. Honda, Yasunori Kitamura, Masaaki Tanaka, John Belz, Hiroyuki Sagawa, Ben Stokes, B. G. Cheon, S. Kawakami, Maxim Pshirkov, Akitoshi Oshima, Y. Tsunesada, M. Abe, Fumio Kakimoto, Vladim Kuzmin, and S. Jeong

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Muon, COSMIC cancer database, Particle number, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Monte Carlo method, Hadron, FOS: Physical sciences, Cosmic ray, 01 natural sciences, law.invention, Telescope, Nuclear physics, Air shower, 13. Climate action, law, 0103 physical sciences, High Energy Physics::Experiment, Astrophysics - High Energy Astrophysical Phenomena, 010306 general physics
Abstract

One of the uncertainties in interpretation of ultra-high energy cosmic ray (UHECR) data comes from the hadronic interaction models used for air shower Monte Carlo (MC) simulations. The number of muons observed at the ground from UHECR-induced air showers is expected to depend upon the hadronic interaction model. One may therefore test the hadronic interaction models by comparing the measured number of muons with the MC prediction. In this paper, we present the results of studies of muon densities in UHE extensive air showers obtained by analyzing the signal of surface detector stations which should have high $\it{muon \, purity}$. The muon purity of a station will depend on both the inclination of the shower and the relative position of the station. In 7 years' data from the Telescope Array experiment, we find that the number of particles observed for signals with an expected muon purity of $\sim$65% at a lateral distance of 2000 m from the shower core is $1.72 \pm 0.10{\rm (stat.)} \pm 0.37 {\rm (syst.)}$ times larger than the MC prediction value using the QGSJET II-03 model for proton-induced showers. A similar effect is also seen in comparisons with other hadronic models such as QGSJET II-04, which shows a $1.67 \pm 0.10 \pm 0.36$ excess. We also studied the dependence of these excesses on lateral distances and found a slower decrease of the lateral distribution of muons in the data as compared to the MC, causing larger discrepancy at larger lateral distances.

Published
2018

202. Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21

Author

Osamu Toyoshima, Chizu Tanikawa, Taiki Yamaji, Koichi Matsuda, Shoichiro Tsugane, Yoshinori Murakami, Naomi Sato, Makoto Hirata, Kenji Wakai, Nobuo Fuse, Takako Takai-Igarashi, Hidemi Ito, Mariko Naito, Haruhiko Sugimura, Keitaro Matsuo, Atsushi Shimizu, Norihiro Furusyo, Atsushi Takahashi, Teruhiko Yoshida, Hiromi Sakamoto, Yoichiro Kamatani, Norie Sawada, Johji Inazawa, Yusuke Nakamura, Issei Imoto, Asahi Hishida, Yukihide Momozawa, Makoto Sasaki, Hiroshi Hirose, Isao Oze, Motoki Iwasaki, Michiaki Kubo, and Fumihiko Tanioka

Subjects
0301 basic medicine, Adult, Male, Cancer Research, ABO, beta-Defensins, Chromosomes, Human, Pair 20, Locus (genetics), Genome-wide association study, Biology, Polymorphism, Single Nucleotide, ABO Blood-Group System, Helicobacter Infections, 03 medical and health sciences, Young Adult, Japan, Stomach Neoplasms, ABO blood group system, Genetic variation, Gene cluster, Humans, Genetic Predisposition to Disease, Gene, Genetics, Genomics, and Proteomics, Aged, genome‐wide association study, Genetics, Aged, 80 and over, Homeodomain Proteins, Chromosomes, Human, Pair 12, CUX2, gastric cancer, Intron, General Medicine, Odds ratio, Original Articles, Middle Aged, 030104 developmental biology, Oncology, Gene Expression Regulation, Case-Control Studies, DEFB, Female, Original Article, Chromosomes, Human, Pair 9, Genome-Wide Association Study
Abstract

Gastric cancer is the third leading cause of cancer mortality in Japan and worldwide. Although previous studies identify various genetic variations associated with gastric cancer, host genetic factors are largely unidentified. To identify novel gastric cancer loci in the Japanese population, herein, we carried out a large-scale genome-wide association study using 6171 cases and 27 178 controls followed by three replication analyses. Analysis using a total of 11 507 cases and 38 904 controls identified two novel loci on 12q24.11-12 (rs6490061, P = 3.20 × 10-8 with an odds ratio [OR] of 0.905) and 20q11.21 (rs2376549, P = 8.11 × 10-10 with an OR of 1.109). rs6490061 is located at intron 19 of the CUX2 gene, and its expression was suppressed by Helicobacter pylori infection. rs2376549 is included within the gene cluster of DEFB families that encode antibacterial peptides. We also found a significant association of rs7849280 in the ABO gene locus on 9q34.2 (P = 2.64 × 10-13 with an OR of 1.148). CUX2 and ABO expression in gastric mucosal tissues was significantly associated with rs6490061 and rs7849280 (P = 0.0153 and 8.00 × 10-11 ), respectively. Our findings show the crucial roles of genetic variations in the pathogenesis of gastric cancer.

Published
2018

203. Tobacco smoking and gastric cancer: meta-analyses of published data versus pooled analyses of individual participant data (StoP Project)

Author

Hidemi Ito, Nuno Lunet, Monica Ferraroni, Carlotta Galeone, Mohammad H. Derakhshan, Nuria Aragonés, Pagona Lagiou, Paola Bertuccio, Bárbara Peleteiro, Keitaro Matsuo, Alicja Wolk, Andrea Bellavia, Gemma Castaño-Vinyals, Jinfu Hu, Lina Mu, Paolo Boffetta, Dmitry Maximovitch, Rossella Bonzi, Robert C. Kurtz, Nicola Orsini, Jesús Vioque, Zuo-Feng Zhang, Huan Song, Carlo La Vecchia, Domenico Palli, Eva María Navarrete-Muñoz, Roberta Pastorino, Areti Lagiou, Weimin Ye, David Zaridze, Mohammadreza Pakseresht, Samantha Morais, Claudio Pelucchi, Niclas Håkansson, Reza Malekzadeh, Kenneth C. Johnson, Eva Negri, Stefania Boccia, Ana Ferro, Joshua E. Muscat, Matteo Rota, Guo-Pei Yu, Farhad Pourfarzi, Intituto de Saúde Pública, Ferro, A. and Morais, S. and Rota, M. and Pelucchi, C. and Bertuccio, P. and Bonzi, R. and Galeone, C. and Zhang, Z.-F. and Matsuo, K. and Ito, H. and Hu, J. and Johnson, K.C. and Yuo, G.-P. and Palli, D. and Ferraroni, M. and Muscat, J. and Malekzadeh, R. and Ye, W. and Song, H. and Zaridze, D. and Maximovitch, D. and Aragonés, N. and Castaño-Vinyals, G. and Vioque, J. and Navarrete-Muñoz, E.M. and Pakseresht, M. and Pourfarzi, F. and Wolk, A. and Orsini, N. and Bellavia, A. and Håkansson, N. and Mu, L. and Pastorino, R. and Kurtz, R.C. and Derakhshan, M.H. and Lagiou, A. and Lagioul, P. and Boffetta, P. and Boccia, S. and Negri, E. and Vecchia, C.L. and Peleteiro, B. and Lunet, N., and Instituto de Saúde Pública

Subjects
Cancer Research, Funnel plot, Meta-Analysi, Epidemiology, MEDLINE, tobacco, Article, smoking, 03 medical and health sciences, 0302 clinical medicine, systematic review, Stomach Neoplasms, Risk Factors, publishing, Tobacco Smoking, Medicine, Humans, human, Stomach cancer, Settore MED/42 - IGIENE GENERALE E APPLICATA, stomach cancer, business.industry, Gastric cancer - Risk factors, gastric cancer, Public Health, Environmental and Occupational Health, Cancer, Medline, Publication bias, Odds ratio, individual participant data, medicine.disease, meta-analysis, Systematic review, pooled analysis, Oncology, priority journal, Pooled analysi, 030220 oncology & carcinogenesis, Meta-analysis, Web of Science, 030211 gastroenterology & hepatology, business, Publication Bias, Demography
Abstract

Tobacco smoking is one of the main risk factors for gastric cancer, but the magnitude of the association estimated by conventional systematic reviews and meta-Analyses might be inaccurate, due to heterogeneous reporting of data and publication bias. We aimed to quantify the combined impact of publication-related biases, and heterogeneity in data analysis or presentation, in the summary estimates obtained from conventional meta-Analyses. We compared results from individual participant data pooled-Analyses, including the studies in the Stomach Cancer Pooling (StoP) Project, with conventional meta-Analyses carried out using only data available in previously published reports from the same studies. Fromthe 23 studies in the StoP Project, 20 had published reports with information on smoking and gastric cancer, but only six had specific data for gastric cardia cancer and seven had data on the daily number of cigarettes smoked. Compared to the results obtained with the StoP database, conventional meta-Analyses overvalued the relation between ever smoking (summary odds ratios ranging from 7% higher for all studies to 22% higher for the risk of gastric cardia cancer) and yielded less precise summary estimates (SE ≤2.4 times higher). Additionally, funnel plot asymmetry and corresponding hypotheses tests were suggestive of publication bias. Conventional meta-Analyses and individual participant data pooled-Analyses reached similar conclusions on the direction of the association between smoking and gastric cancer. However, published data tended to overestimate the magnitude of the effects, possibly due to publication biases and limited the analyses by different levels of exposure or cancer subtypes. European Journal of Cancer Prevention 27:197-204 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

Published
2018

204. Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

Author

Maya Ghoussaini, Stacey L. Edwards, Kyriaki Michailidou, Silje Nord, Richard Cowper-Sal·lari, Kinjal Desai, Siddhartha Kar, Kristine M. Hillman, Susanne Kaufmann, Dylan M. Glubb, Jonathan Beesley, Joe Dennis, Manjeet K. Bolla, Qin Wang, Ed Dicks, Qi Guo, Marjanka K. Schmidt, Mitul Shah, Robert Luben, Judith Brown, Kamila Czene, Hatef Darabi, Mikael Eriksson, Daniel Klevebring, Stig E. Bojesen, Børge G. Nordestgaard, Sune F. Nielsen, Henrik Flyger, Diether Lambrechts, Bernard Thienpont, Patrick Neven, Hans Wildiers, Annegien Broeks, Laura J. Van’t Veer, Emiel J. Th Rutgers, Fergus J. Couch, Janet E. Olson, Emily Hallberg, Celine Vachon, Jenny Chang-Claude, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Julian Peto, Isabel dos-Santos-Silva, Lorna Gibson, Heli Nevanlinna, Taru A. Muranen, Kristiina Aittomäki, Carl Blomqvist, Per Hall, Jingmei Li, Jianjun Liu, Keith Humphreys, Daehee Kang, Ji-Yeob Choi, Sue K. Park, Dong-Young Noh, Keitaro Matsuo, Hidemi Ito, Hiroji Iwata, Yasushi Yatabe, Pascal Guénel, Thérèse Truong, Florence Menegaux, Marie Sanchez, Barbara Burwinkel, Frederik Marme, Andreas Schneeweiss, Christof Sohn, Anna H. Wu, Chiu-chen Tseng, David Van Den Berg, Daniel O. Stram, Javier Benitez, M Pilar Zamora, Jose Ignacio Arias Perez, Primitiva Menéndez, Xiao-Ou Shu, Wei Lu, Yu-Tang Gao, Qiuyin Cai, Angela Cox, Simon S. Cross, Malcolm W. R. Reed, Irene L. Andrulis, Julia A. Knight, Gord Glendon, Sandrine Tchatchou, Elinor J. Sawyer, Ian Tomlinson, Michael J. Kerin, Nicola Miller, Christopher A. Haiman, Brian E. Henderson, Fredrick Schumacher, Loic Le Marchand, Annika Lindblom, Sara Margolin, Soo Hwang Teo, Cheng Har Yip, Daphne S. C. Lee, Tien Y. Wong, Maartje J. Hooning, John W. M. Martens, J. Margriet Collée, Carolien H. M. van Deurzen, John L. Hopper, Melissa C. Southey, Helen Tsimiklis, Miroslav K. Kapuscinski, Chen-Yang Shen, Pei-Ei Wu, Jyh-Cherng Yu, Shou-Tung Chen, Grethe Grenaker Alnæs, Anne-Lise Borresen-Dale, Graham G. Giles, Roger L. Milne, Catriona McLean, Kenneth Muir, Artitaya Lophatananon, Sarah Stewart-Brown, Pornthep Siriwanarangsan, Mikael Hartman, Hui Miao, Shaik Ahmad Bin Syed Buhari, Yik Ying Teo, Peter A. Fasching, Lothar Haeberle, Arif B. Ekici, Matthias W. Beckmann, Hermann Brenner, Aida Karina Dieffenbach, Volker Arndt, Christa Stegmaier, Anthony Swerdlow, Alan Ashworth, Nick Orr, Minouk J. Schoemaker, Montserrat García-Closas, Jonine Figueroa, Stephen J. Chanock, Jolanta Lissowska, Jacques Simard, Mark S. Goldberg, France Labrèche, Martine Dumont, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Hiltrud Brauch, Thomas Brüning, Yon-Dschun Koto, Paolo Radice, Paolo Peterlongo, Bernardo Bonanni, Sara Volorio, Thilo Dörk, Natalia V. Bogdanova, Sonja Helbig, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Peter Devilee, Robert A. E. M. Tollenaar, Caroline Seynaeve, Christi J. Van Asperen, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Susan Slager, Amanda E. Toland, Christine B. Ambrosone, Drakoulis Yannoukakos, Suleeporn Sangrajrang, Valerie Gaborieau, Paul Brennan, James McKay, Ute Hamann, Diana Torres, Wei Zheng, Jirong Long, Hoda Anton-Culver, Susan L. Neuhausen, Craig Luccarini, Caroline Baynes, Shahana Ahmed, Mel Maranian, Catherine S. Healey, Anna González-Neira, Guillermo Pita, M Rosario Alonso, Nuria Álvarez, Daniel Herrero, Daniel C. Tessier, Daniel Vincent, Francois Bacot, Ines de Santiago, Jason Carroll, Carlos Caldas, Melissa A. Brown, Mathieu Lupien, Vessela N. Kristensen, Paul D. P. Pharoah, Georgia Chenevix-Trench, Juliet D. French, Douglas F. Easton, and Alison M. Dunning

Subjects
Oncology, medicine.medical_specialty, Multidisciplinary, business.industry, Published Erratum, MEDLINE, General Physics and Astronomy, Locus (genetics), General Chemistry, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, 030220 oncology & carcinogenesis, Internal medicine, medicine, 030212 general & internal medicine, business
Abstract

GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the ‘iCOGS’ genotyping array and impute genotypes for a further 1,284 using 1000 Genomes Project data. All but two, strongly correlated SNPs (rs4442975 G/T and rs6721996 G/A) are excluded as candidate causal variants at odds against >100:1. The best functional candidate, rs4442975, is associated with oestrogen receptor positive (ER+) disease with an odds ratio (OR) in Europeans of 0.85 (95% confidence interval=0.84−0.87; P=1.7 × 10−43) per t-allele. This SNP flanks a transcriptional enhancer that physically interacts with the promoter of IGFBP5 (encoding insulin-like growth factor-binding protein 5) and displays allele-specific gene expression, FOXA1 binding and chromatin looping. Evidence suggests that the g-allele confers increased breast cancer susceptibility through relative downregulation of IGFBP5, a gene with known roles in breast cell biology., Previous studies identified an association between the 2q35 locus and breast cancer. Here, the authors show that a SNP at 2q35, rs4442975, is associated with oestrogen receptor positive disease and suggest that this effect is mediated through the downregulation of a known breast cancer gene, IGFBP5.

Published
2018

205. Recent Improvement in the Long-term Survival of Breast Cancer Patients by Age and Stage in Japan

Author

Tomio Nakayama, Hidemi Ito, Hiroji Iwata, Yoshikazu Nishino, Keitaro Matsuo, Masakazu Hattori, Isao Miyashiro, Hideo Tanaka, Akiyo Yoshimura, Yuri Ito, and Tomohiro Matsuda

Subjects
Adult, medicine.medical_specialty, Adolescent, Epidemiology, Population, Breast Neoplasms, period analysis, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Breast cancer, Age Distribution, breast cancer, Cancer Survivors, Japan, Internal medicine, medicine, Humans, cancer registration, 030212 general & internal medicine, Stage (cooking), education, Aged, Neoplasm Staging, Cancer, Aged, 80 and over, lcsh:R5-920, education.field_of_study, Relative survival, business.industry, relative survival, General Medicine, Middle Aged, medicine.disease, Survival Analysis, Cancer registry, 030220 oncology & carcinogenesis, Localized disease, Female, Original Article, lcsh:Medicine (General), business, long-term survival, Cohort study
Abstract

Background: Recent improvements in 5-year survival of breast cancer have been reported in Japan and other countries. Though the number of long-term breast cancer survivors has been increasing, recent improvements in 10-year survival have not been reported. Moreover, the degree of improvement according to age and disease stage remains unclear. Methods: We calculated long-term survival using data on breast cancer diagnosed from 1993 through 2006 from six prefectural population-based cancer registries in Japan. The recent increase in 10-year relative survival was assessed by comparing the results of period analysis in 2002–2006 with the results of cohort analysis in 1993–1997. We also conducted stratified analyses by age group (15–34, 35–49, 50–69, and 70–99 years) and disease stage (localized, regional, and distant). Results: A total of 63,348 patients were analysed. Ten-year relative survival improved by 2.4% (76.9% vs 79.3%) from 1993 through 2006. By age and stage, 10-year relative survival clearly improved in the age 35–49 years (+2.9%; 78.1% vs 81.0%), 50–69 years (+2.8%; 75.2% vs 78.0%) and regional disease (+3.4%; 64.9% vs 68.3%). In contrast, the degree of improvement was small in the age 15–34 years (+0.1%; 68.2% vs 68.3%), 70–99 years (+1.0%; 87.6% vs 88.6%), localized disease (+1.1%; 92.6% vs 93.7%) and distant metastasis (+0.9%; 13.8% vs 14.7%). Conclusions: These population-based cancer registry data show that 10-year relative survival improved 2.4% over this period in Japan. By age and stage, improvement in the age 15–34 years and distant metastasis was very small, which suggests the need for new therapeutic strategies in these patients.

Published
2018

206. Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population

Author

Hidemi Ito, Mariko Sasaki, Miki Watanabe, Toru Takebayashi, Kazuo Tsubota, Hideo Tanaka, Yumiko Kawasaki, Yuji Nishiwaki, Ayano Takeuchi, Sei Harada, and Ryo Kawasaki

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Science, Disease, Polymorphism, Single Nucleotide, Article, Cohort Studies, Macular Degeneration, 03 medical and health sciences, chemistry.chemical_compound, Sex Factors, 0302 clinical medicine, Japan, Risk Factors, Internal medicine, Odds Ratio, medicine, Humans, Aged, Multidisciplinary, Cholesterol, business.industry, Cholesterol, HDL, Proteins, Cholesterol, LDL, Odds ratio, Middle Aged, Macular degeneration, medicine.disease, eye diseases, Confidence interval, Logistic Models, 030104 developmental biology, Clinical research, chemistry, Complement Factor H, Cohort, 030221 ophthalmology & optometry, Medicine, Female, business, Cohort study
Abstract

The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of these, 3,988 subjects had fundus photographs of sufficient quality, and early AMD was present in 12.3% and 10.3% of men and women, respectively. In men, higher levels of high-density lipoprotein cholesterol and lower levels of triglycerides were associated with increased odds of having early AMD after adjusting for potential risk factors (for each 1 mmol/L increase, odds ratio [OR]: 1.61 and 0.78, 95% confidence interval [CI]: 1.17–2.23 and 0.64–0.96, respectively). In women, higher levels of total cholesterol and low-density lipoprotein cholesterol were associated with increased risk of having early AMD (OR: 1.21 and 1.26, 95% CI: 1.01–1.44 and 1.03–1.53, respectively). Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10–5.04) than men (OR: 1.65, 95% CI: 1.02–2.69). Differential associations of early AMD with both systemic and genetic factors by sex were demonstrated in a Japanese cohort, which suggests that disease process of early AMD could be different by sex.

Published
2018

207. Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)

Author

Paolo Boffetta, Hidemi Ito, Nuno Lunet, Lina Mu, Keitaro Matsuo, Monica Ferraroni, Nerea Fernández de Larrea, Joshua E. Muscat, Mohammad H. Derakhshan, Pagona Lagiou, Matteo Rota, Robert C. Kurtz, Claudio Pelucchi, Carlotta Galeone, Bárbara Peleteiro, Farhad Pourfarzi, Mohammadreza Pakseresht, Reza Malekzadeh, Weimin Ye, Guo Pei Yu, Stefania Boccia, Kenneth C. Johnson, Huan Song, Paola Bertuccio, Zuo-Feng Zhang, Alicja Wolk, Nicola Orsini, Dmitry Maximovitch, Carlo La Vecchia, Jinfu Hu, Niclas Håkansson, Manolis Kogevinas, Areti Lagiou, Andrea Bellavia, Domenico Palli, Jesús Vioque, Eva María Navarrete-Muñoz, Samantha Morais, Eva Negri, David Zaridze, Rossella Bonzi, Ana Ferro, Roberta Pastorino, and Ferro, A. and Morais, S. and Rota, M. and Pelucchi, C. and Bertuccio, P. and Bonzi, R. and Galeone, C. and Zhang, Z.-F. and Matsuo, K. and Ito, H. and Hu, J. and Johnson, K.C. and Yu, G.-P. and Palli, D. and Ferraroni, M. and Muscat, J. and Malekzadeh, R. and Ye, W. and Song, H. and Zaridze, D. and Maximovitch, D. and Fernández de Larrea, N. and Kogevinas, M. and Vioque, J. and Navarrete-Muñoz, E.M. and Pakseresht, M. and Pourfarzi, F. and Wolk, A. and Orsini, N. and Bellavia, A. and Håkansson, N. and Mu, L. and Pastorino, R. and Kurtz, R.C. and Derakhshan, M.H. and Lagiou, A. and Lagiou, P. and Boffetta, P. and Boccia, S. and Negri, E. and La Vecchia, C. and Peleteiro, B. and Lunet, N.

Subjects
Cancer Research, Funnel plot, Alcohol Drinking, alcohol, gastric cancer, individual participant data, meta-analysis, pooled analysis, publication bias, Epidemiology, alcohol consumption, cancer risk, Publication bias, Article, Pooled analysis, Alcohol, Gastric cancer, Individual participant data, Meta-analysis, Pooled analysis, Publication bias, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, medicine, Odds Ratio, Humans, Meta-analysi, human, 030212 general & internal medicine, Stomach cancer, Settore MED/42 - IGIENE GENERALE E APPLICATA, comparative study, cardia carcinoma, stomach cancer, meta analysi, business.industry, drinking behavior, Cancer, Individual participant data, Odds ratio, medicine.disease, 3. Good health, Meta-analysis, Standard error, Systematic review, priority journal, Pooled analysi, Oncology, 030220 oncology & carcinogenesis, business, Alcohol, Gastric cancer, cancer epidemiology, Demography
Abstract

Background: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer. Methods: We compared estimates obtained from conventional meta-analyses, using only data available in published reports from studies that take part in the Stomach Cancer Pooling (StoP) Project, with individual participant data pooled analyses including the same studies. Results: A total of 22 studies from the StoP Project assessed the relation between alcohol intake and gastric cancer, 19 had specific data for levels of consumption and 18 according to cancer location; published reports addressing these associations were available from 18, 5 and 5 studies, respectively. The summary odds ratios [OR, (95%CI)] estimate obtained with published data for drinkers vs. non-drinkers was 10% higher than the one obtained with individual StoP data [18 vs. 22 studies: 1.21 (1.07-1.36) vs. 1.10 (0.99-1.23)] and more heterogeneous (1(2): 63.6% vs 54.4%). In general, published data yielded less precise summary estimates (standard errors up to 2.6 times higher). Funnel plot analysis suggested publication bias. Conclusion: Meta-analyses of the association between alcohol drinking and gastric cancer tended to overestimate the magnitude of the effects, possibly due to publication bias. Additionally, individual participant data pooled analyses yielded more precise estimates for different levels of exposure or cancer subtypes.

Published
2018

208. Depth of Ultra High Energy Cosmic Ray Induced Air Shower Maxima Measured by the Telescope Array Black Rock and Long Ridge FADC Fluorescence Detectors and Surface Array in Hybrid Mode

Author

R. Azuma, M. Yamamoto, Nobuyuki Sakurai, Ryota Onogi, A. Di Matteo, R. Mayta, B. G. Cheon, Fumiya Shibata, K. Martens, Hideki Tanaka, R. Ishimori, K. H. Lee, M. Abe, T.-A. Shibata, Gordon Thomson, Tom Stroman, Robert Cady, H. Tokuno, S. Kitamura, Priti Shah, T. Goto, K. Tsutsumi, Hideaki Shimodaira, Hyoming Jeong, Rasha Abbasi, S. Kawakami, Akimichi Taketa, Hidemi Ito, Jyunsei Chiba, Dongsu Ryu, J. D. Smith, J. Ogura, Toshiyuki Nonaka, Kiyoshi Tanaka, Akitoshi Oshima, Y. Takagi, G. Furlich, Takaaki Ishii, Shunsuke Ozawa, O. Kalashev, BayarJon Paul Lubsandorzhiev, Hiroshi Yamaoka, Mayuko Minamino, K. Honda, Y. Zhezher, Hiroyuki Sagawa, Keitaro Fujita, Yasunori Kitamura, Peter Tinyakov, Samuel Blake, D. C. Rodriguez, Shoichi Ogio, Ben Stokes, Toshitsugu Fujii, T. Matsuyama, Elliott Barcikowski, B. K. Shin, K. Yamazaki, Dmitri Ivanov, T. Suzawa, M. Allen, Masaaki Tanaka, K. Hibino, R. Sahara, Heungsu Shin, Zach Zundel, Ryo Nakamura, Keijiro Mukai, Isaac Myers, Kazuo Saito, Inkyu Park, Hongsu Kim, Pierre Sokolsky, S. Yoshida, Eiji Kido, Naoto Sakaki, Grigory Rubtsov, M. V. Kuznetsov, M. Takeda, John Belz, Vladim Kuzmin, H. Yoshii, Kazuhiro Machida, Shigehiro Nagataki, S. Jeong, Michiyuki Chikawa, H. Kawai, Tareq Abu-Zayyad, R. Yamane, K. Nagasawa, Douglas Bergman, Y. J. Kwon, Hideyuki Ohoka, Yasunori Saito, T. Seki, Yoshiki Tsunesada, Daisuke Ikeda, S. R. Stratton, Y. Uchihori, L. M. Scott, Tiffany Wong, R. Takeishi, Masaki Fukushima, Toru Nakamura, Y. Hayashi, Yuichiro Tameda, K. Kawata, John N. Matthews, Masato Takita, Kenichi Kadota, Sergey Troitsky, J. H. Kim, Y. Omura, Shingo Kawana, Naoaki Hayashida, William Hanlon, Igor Tkachev, T. Okuda, J. Yang, H. Oda, Kenta Yashiro, Y. Yoneda, N. Inoue, M. Ohnishi, Federico R. Urban, S. Udo, C. C. H. Jui, S. B. Thomas, Takayuki Tomida, K. Kasahara, Shoichi Kishigami, Masaomi Ono, Maxim Pshirkov, Motoki Hayashi, J. P. Lundquist, Koichi Sekino, Y. Takahashi, Mai Takamura, and Fumio Kakimoto

Subjects
Astrophysics::High Energy Astrophysical Phenomena, chemistry.chemical_element, FOS: Physical sciences, Cosmic ray, 7. Clean energy, 01 natural sciences, law.invention, Telescope, Optics, Observatory, law, 0103 physical sciences, Ultra-high-energy cosmic ray, 010303 astronomy & astrophysics, Helium, Astroparticle physics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, business.industry, Astronomy and Astrophysics, Air shower, chemistry, 13. Climate action, Space and Planetary Science, Ridge (meteorology), Astrophysics - High Energy Astrophysical Phenomena, business
Abstract

The Telescope Array observatory utilizes fluorescence detectors and surface detectors to observe air showers produced by ultra high energy cosmic rays in the Earth's atmosphere. Cosmic ray events observed in this way are termed hybrid data. The depth of air shower maximum is related to the mass of the primary particle that generates the shower. This paper reports on shower maxima data collected over 8.5 years using the Black Rock Mesa and Long Ridge fluorescence detectors in conjunction with the array of surface detectors. We compare the means and standard deviations of the observed $X_{\mathrm{max}}$ distributions with Monte Carlo $X_{\mathrm{max}}$ distributions of unmixed protons, helium, nitrogen, and iron, all generated using the QGSJet~II-04 hadronic model. We also perform an unbinned maximum likelihood test of the observed data, which is subjected to variable systematic shifting of the data $X_{\mathrm{max}}$ distributions to allow us to test the full distributions, and compare them to the Monte Carlo to see which elements are not compatible with the observed data. For all energy bins, QGSJet~II-04 protons are found to be compatible with Telescope Array hybrid data at the 95% confidence level after some systematic $X_{\mathrm{max}}$ shifting of the data. Three other QGSJet~II-04 elements are found to be compatible using the same test procedure in an energy range limited to the highest energies where data statistics are sparse., Comment: 39 pages, 18 figures, 5 tables, published in The Astrophysical Journal. This is a peer-reviewed, un-copyedited version of an article published in The Astrophysical Journal. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.3847/1538-4357/aabad7

Published
2018
Full Text
View/download PDF

209. Evidence of Intermediate-Scale Energy Spectrum Anisotropy of Cosmic Rays E$\geq$10$^{19.2}$ eV with the Telescope Array Surface Detector

Author

N. Inoue, M. Ohnishi, R. Sahara, Toru Nakamura, S. Udo, Kenichi Kadota, Maxim Pshirkov, K. Kasahara, M. Abe, Shoichi Kishigami, T. Goto, Toshiyuki Nonaka, Zach Zundel, S. B. Thomas, Fumio Kakimoto, Masaomi Ono, Jyunsei Chiba, Charlie Jui, Dongsu Ryu, B. K. Shin, Hiroshi Yamaoka, Yoshiki Tsunesada, Daisuke Ikeda, Kenta Yashiro, Keitaro Fujita, BayarJon Paul Lubsandorzhiev, Ben Stokes, S. R. Stratton, Y. Takagi, Tiffany Wong, Mayuko Minamino, K. Honda, Masaki Fukushima, H. Tokuno, Yasunori Kitamura, K. Martens, Masato Takita, Hideki Tanaka, Takayuki Tomida, Masaaki Tanaka, J. D. Smith, Fumiya Shibata, Sergey Troitsky, S. Kitamura, R. Ishimori, Keiji Saito, Igor Tkachev, Michiyuki Chikawa, Eiji Kido, M. V. Kuznetsov, D. R. Bergman, H. Oda, Kazuhiro Machida, Hidemi Ito, Pierre Sokolsky, Y. Uchihori, Y. J. Kwon, Hideyuki Ohoka, R. Takeishi, Yasunori Saito, Shigehiro Nagataki, Akitoshi Oshima, T. Matsuyama, Yana Zhezher, T. Suzawa, Shunsuke Ozawa, Shingo Kawana, Yuichiro Tameda, John N. Matthews, Priti Shah, O. Kalashev, Vladim Kuzmin, William Hanlon, J. Ogura, F. Urban, S. Jeong, Isaac Myers, Motoki Hayashi, Peter Tinyakov, J. P. Lundquist, Samuel Blake, Shoichi Ogio, T. Okuda, J. Yang, M. Allen, Y. Omura, Naoaki Hayashida, Koichi Sekino, Elliott Barcikowski, K. Nagasawa, Dmitri Ivanov, Y. Takahashi, Mai Takamura, G. Furlich, Takaaki Ishii, Keijiro Mukai, D. C. Rodriguez, S. Yoshida, Naoto Sakaki, Rasha Abbasi, Kiyoshi Tanaka, John Belz, R. Azuma, Inkyu Park, L. M. Scott, A. Nozato, Y. Hayashi, K. Kawata, Hideaki Shimodaira, Hyoming Jeong, K. H. Lee, Tareq Abu-Zayyad, Hiroyuki Sagawa, T.-A. Shibata, R. Yamane, Gordon Thomson, Ryo Nakamura, Tom Stroman, Robert Cady, Hongsu Kim, Akimichi Taketa, Grigory Rubtsov, M. Yamamoto, H. Yoshii, Nobuyuki Sakurai, K. Yamazaki, Takahiro Fujii, Ryota Onogi, J. H. Kim, A. Di Matteo, B. G. Cheon, R. Mayta, K. Hibino, S. Kawakami, Heungsu Shin, K. Tsutsumi, H. Kawai, T. Seki, and Y. Yoneda

Subjects
Astroparticle physics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, Detector, Monte Carlo method, Isotropy, FOS: Physical sciences, Astronomy and Astrophysics, Cosmic ray, Astrophysics, Poisson distribution, 01 natural sciences, law.invention, Telescope, symbols.namesake, Space and Planetary Science, law, 0103 physical sciences, symbols, Anisotropy, Astrophysics - High Energy Astrophysical Phenomena, 010303 astronomy & astrophysics
Abstract

An intermediate-scale energy spectrum anisotropy has been found in the arrival directions of ultra-high energy cosmic rays of energies above $10^{19.2}$ eV in the northern hemisphere, using 7 years of data from the Telescope Array surface detector. A relative energy distribution test is done comparing events inside oversampled spherical caps of equal exposure, to those outside, using the Poisson likelihood ratio. The center of maximum significance is at $9^h$$16^m$, $45^{\circ}$. and has a deficit of events with energies $10^{19.2}$$\leq$$E$$

Published
2018
Full Text
View/download PDF

210. Constraints on the diffuse photon flux with energies above $10^{18}$ eV using the surface detector of the Telescope Array experiment

Author

Rasha Abbasi, Fumiya Shibata, S. Yoshida, T. Matsuyama, S. Ozawa, Naoto Sakaki, Yasunori Saito, John Belz, K. Nagasawa, R. Ishimori, S. Kitamura, Hidemi Ito, Ryo Nakamura, Motoki Hayashi, Toshiyuki Nonaka, Hideki Tanaka, Kazuo Saito, J. P. Lundquist, M. Yamamoto, Ben Stokes, B. G. Cheon, Heungsu Shin, T. Suzawa, Yuichiro Tameda, Isaac Myers, Inkyu Park, John N. Matthews, Douglas Bergman, Nobuyuki Sakurai, Ryota Onogi, A. Di Matteo, Koichi Sekino, M. Allen, R. Mayta, Y. Zhezher, Grigory Rubtsov, Kenta Yashiro, K. Martens, K. Tsutsumi, Keitaro Fujita, Y. Takahashi, Mai Takamura, L. M. Scott, H. Yoshii, Daisuke Ikeda, Eiji Kido, M. V. Kuznetsov, S. Kawakami, Y. Uchihori, R. Azuma, Toshitsugu Fujii, Kazuhiro Machida, S. R. Stratton, Y. Hayashi, Sergey Troitsky, B. K. Shin, Oleg Kalashev, Hongsu Kim, Hiroyuki Sagawa, Tiffany Wong, R. Takeishi, Charlie Jui, J. Remington, Pierre Sokolsky, K. Kawata, Masaki Fukushima, Akimichi Taketa, G. Furlich, Takaaki Ishii, J. H. Kim, BayarJon Paul Lubsandorzhiev, M. Takeda, Shigehiro Nagataki, Mayuko Minamino, Hideaki Shimodaira, Hyoming Jeong, D. C. Rodriguez, H. Kawai, Y. Omura, Kiyoshi Tanaka, K. Kasahara, K. Honda, Akitoshi Oshima, Y. Tsunesada, Shoichi Kishigami, Yasunori Kitamura, Naoaki Hayashida, Masaaki Tanaka, T. Seki, Masato Takita, J. Ogura, H. Yamaoka, Masaomi Ono, R. Sahara, Michiyuki Chikawa, Y. Yoneda, N. Inoue, Jyunsei Chiba, K. Hibino, Shingo Kawana, Fumio Kakimoto, Dongsu Ryu, K. Yamazaki, Tareq Abu-Zayyad, R. Yamane, Maksim Piskunov, William Hanlon, M. Ohnishi, Takayuki Tomida, Y. Takagi, T. Okuda, J. Yang, Federico R. Urban, Toru Nakamura, S. Udo, K. H. Lee, Kenichi Kadota, T.-A. Shibata, H. Tokuno, Zach Zundel, J. D. Smith, Priti Shah, Gordon Thomson, S. B. Thomas, Tom Stroman, Robert Cady, Igor Tkachev, Maxim Pshirkov, Elliott Barcikowski, Dmitri Ivanov, H. Oda, Keijiro Mukai, Peter Tinyakov, Samuel Blake, Shoichi Ogio, Vladim Kuzmin, T. Goto, S. Jeong, M. Abe, Y. J. Kwon, and Hideyuki Ohoka

Subjects
Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Muon, Photon, 010308 nuclear & particles physics, Detector, FOS: Physical sciences, Astronomy and Astrophysics, Curvature, 01 natural sciences, Computational physics, law.invention, High Energy Physics - Experiment, Telescope, High Energy Physics - Phenomenology, High Energy Physics - Experiment (hep-ex), Air shower, Distribution function, High Energy Physics - Phenomenology (hep-ph), law, 0103 physical sciences, Waveform, Astrophysics - High Energy Astrophysical Phenomena, 010303 astronomy & astrophysics
Abstract

We present the results of the search for ultra-high-energy photons with nine years of data from the Telescope Array surface detector. A multivariate classifier is built upon 16 reconstructed parameters of the extensive air shower. These parameters are related to the curvature and the width of the shower front, the steepness of the lateral distribution function, and the timing parameters of the waveforms sensitive to the shower muon content. A total number of two photon candidates found in the search is fully compatible with the expected background. The $95\%\,$CL limits on the diffuse flux of the photons with energies greater than $10^{18.0}$, $10^{18.5}$, $10^{19.0}$, $10^{19.5}$ and $10^{20.0}$ eV are set at the level of $0.067$, $0.012$, $0.0036$, $0.0013$, $0.0013~\mbox{km}^{-2}\mbox{yr}^{-1}\mbox{sr}^{-1}$ correspondingly., Comment: 7 pages, 2 figures

Published
2018
Full Text
View/download PDF

211. Mass composition of ultra-high-energy cosmic rays with the Telescope Array Surface Detector Data

Author

J. Remington, Koichi Sekino, S. Kitamura, Hidemi Ito, M. Yamamoto, Nobuyuki Sakurai, Ryota Onogi, A. Di Matteo, R. Mayta, Naoaki Hayashida, J. H. Kim, H. Tokuno, B. G. Cheon, Y. Takahashi, Mai Takamura, Pierre Sokolsky, Y. Omura, T. Suzawa, J. D. Smith, S. Yoshida, Naoto Sakaki, M. Takeda, Shigehiro Nagataki, T. Goto, Douglas Bergman, K. Nagasawa, Toshitsugu Fujii, K. Hibino, R. Azuma, Takayuki Tomida, BayarJon Paul Lubsandorzhiev, Kenta Yashiro, Yasunori Saito, Ryo Nakamura, Mayuko Minamino, K. Honda, Isaac Myers, Yasunori Kitamura, S. Kawakami, Kazuo Saito, O. Kalashev, K. Tsutsumi, Fumio Kakimoto, John Belz, Yuichiro Tameda, John N. Matthews, K. Martens, Toru Nakamura, Grigory Rubtsov, Maxim S. Piskunov, H. Yoshii, Masaaki Tanaka, Priti Shah, Fumiya Shibata, R. Ishimori, Kenichi Kadota, Hideki Tanaka, T. Matsuyama, L. M. Scott, Michiyuki Chikawa, K. Yamazaki, Hiroyuki Sagawa, Kohei Yada, Y. Hayashi, Shingo Kawana, R. Sahara, K. H. Lee, T.-A. Shibata, Gordon Thomson, Tom Stroman, Robert Cady, Y. J. Kwon, Hideyuki Ohoka, Elliott Barcikowski, Toshiyuki Nonaka, Dmitri Ivanov, Motoki Hayashi, M. Allen, K. Kawata, S. Ozawa, William Hanlon, J. P. Lundquist, Jyunsei Chiba, Dongsu Ryu, K. Kasahara, Shoichi Kishigami, Daisuke Ikeda, Keijiro Mukai, S. R. Stratton, G. Furlich, Takaaki Ishii, Hiroshi Yamaoka, Keitaro Fujita, Masato Takita, T. Okuda, J. Yang, Hongsu Kim, Masaomi Ono, B. K. Shin, Hideaki Shimodaira, Hyoming Jeong, Tiffany Wong, R. Takeishi, Heungsu Shin, Inkyu Park, Masaki Fukushima, Maxim Pshirkov, D. C. Rodriguez, Akimichi Taketa, Y. Takagi, Eiji Kido, Rasha Abbasi, M. V. Kuznetsov, Kazuhiro Machida, Kiyoshi Tanaka, H. Kawai, Igor Tkachev, J. Ogura, Tareq Abu-Zayyad, R. Yamane, Vladim Kuzmin, T. Seki, S. Jeong, Zach Zundel, Yana Zhezher, Peter Tinyakov, Samuel Blake, Shoichi Ogio, Y. Uchihori, H. Oda, Ben Stokes, M. Abe, Y. Yoneda, N. Inoue, M. Ohnishi, Federico R. Urban, Akitoshi Oshima, Y. Tsunesada, S. Udo, C. C. H. Jui, S. B. Thomas, and Sergey Troitsky

Subjects
Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Library science, FOS: Physical sciences, Mass composition, 01 natural sciences, Promotion (rank), State (polity), Work (electrical), George (robot), 0103 physical sciences, Science policy, High Energy Physics::Experiment, Ultrahigh energy, 010306 general physics, Astrophysics - High Energy Astrophysical Phenomena, Administration (government), media_common
Abstract

The results on ultra-high-energy cosmic rays (UHECR) mass composition obtained with the Telescope Array surface detector are presented. The analysis employs the boosted decision tree (BDT) multivariate analysis built upon 14 observables related to both the properties of the shower front and the lateral distribution function. The multivariate classifier is trained with Monte-Carlo sets of events induced by the primary protons and iron. An average atomic mass of UHECR is presented for energies $10^{18.0}-10^{20.0}\ \mbox{eV}$. The average atomic mass of primary particles shows no significant energy dependence and corresponds to $\langle \ln A \rangle = 2.0 \pm 0.1 (stat.) \pm 0.44 (syst.)$. The result is compared to the mass composition obtained by the Telescope Array with $\mbox{X}_{\mbox{max}}$ technique along with the results of other experiments. Possible systematic errors of the method are discussed., Comment: 11 pages, 9 figures

Published
2018
Full Text
View/download PDF

212. Declining trends in prevalence of Helicobacter pylori infection by birth‐year in a Japanese population

Author

Hideo Tanaka, Keitaro Matsuo, Kazuo Tajima, Hidemi Ito, Hisato Katoh, Miki Watanabe, Isao Oze, Chieko Ashida, and Satoyo Hosono

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Helicobacter pylori infection, Cross-sectional study, Gastroenterology, Helicobacter Infections, Young Adult, Age Distribution, Asian People, Japan, Pepsin, Stomach Neoplasms, Internal medicine, Prevalence, medicine, Humans, pepsinogen, Young adult, Birth Year, Aged, Helicobacter pylori, biology, business.industry, Antibody titer, Epidemiology and Prevention, Cancer, Original Articles, General Medicine, Middle Aged, medicine.disease, biology.organism_classification, Cross-Sectional Studies, high‐risk individuals, Oncology, Immunology, Helicobacter pylori antibody, biology.protein, Female, Original Article, Gastric cancer, business
Abstract

Gastric cancer incidence and mortality have been decreasing in Japan. These decreases are likely due to a decrease in prevalence of Helicobacter pylori infection. Our aim was to characterize the trends in prevalence of H. pylori infection focused on birth‐year. We carried out a cross‐sectional study that included 4285 subjects who were born from 1926 to 1989. We defined H. pylori infection by the serum H. pylori antibody titer. Individuals having H. pylori infection and those with negative H. pylori antibody titer and positive pepsinogen test were defined as high‐risk individuals for gastric cancer. We estimated the birth‐year percent change (BPC) of the prevalence by Joinpoint regression analysis. The prevalence of H. pylori infection among the subjects born from 1927 to 1949 decreased from 54.0% to 42.0% with a BPC of −1.2%. It was followed by a rapid decline in those born between 1949 (42.0%) and 1961 (24.0%) with a BPC of −4.5%, which was followed by those born between 1961 (24.0%) and 1988 (14.0%) with a BPC of −2.1%. The proportion of high‐risk individuals for gastric cancer among the subjects born from 1927 to 1942 decreased from 62.0% to 55.0% with a BPC of −0.8%. A subsequent rapid declining trend was observed in those born between 1942 (55.0%) and 1972 (18.0%) with a BPC of −3.6%, and then it became stable. These remarkable declining trends in the prevalence of H. pylori infection by birth‐year would be useful to predict the future trend in gastric cancer incidence in Japan.

Published
2015

213. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression

Author

Christopher A. Haiman, Pascal Guénel, Hidemi Ito, Susan L. Neuhausen, Christy G. Woolcott, Graham G. Giles, Anthony J. Swerdlow, Per Hall, Kamila Czene, Artitaya Lophatananon, Åslaug Helland, Yu-Tang Gao, Vessela N. Kristensen, Manjeet K. Bolla, Anna H. Wu, Jacques Simard, John L. Hopper, Robert Luben, Julia A. Knight, Mark S. Goldberg, Thilo Dörk, Kay-Tee Khaw, Christopher G. Scott, Giuseppe Floris, Jennifer Stone, Madeleine M.A. Tilanus-Linthorst, Stig E. Bojesen, Daehee Kang, Qin Wang, Angela Cox, Fergus J. Couch, Jonathan Beesley, Maartje J. Hooning, Natalia Bogdanova, Brian E. Henderson, Paolo Peterlongo, Rulla M. Tamimi, Soo Hwang Teo, Diether Lambrechts, Ute Hamann, Wei Zheng, Volker Arndt, Juliet D. French, Stacey L. Edwards, Julian Peto, Ian Tomlinson, Ji Yeob Choi, Elinor J. Sawyer, Melissa C. Southey, Annegien Broeks, Arif B. Ekici, Heli Nevanlinna, Celine M. Vachon, Thérèse Truong, Amanda E. Toland, Javier Benitez, Barbara Burwinkel, Xiao-Ou Shu, Robert Winqvist, Pierre Antoine Dugué, Karen McCue, Mikael Hartman, Minouk J. Schoemaker, Keitaro Matsuo, Norbert Arnold, Deborah J. Thompson, Paolo Radice, Anna Jakubowska, Marjanka K. Schmidt, Hermann Brenner, Hoda Anton-Culver, Argyrios Ziogas, Jenny Chang-Claude, Alicia Beeghly-Fadiel, Veli-Matti Kosma, Hatef Darabi, Drakoulis Yannoukakos, Maya Ghoussaini, Rodney J. Scott, Maria Kabisch, Chen-Yang Shen, Suleeporn Sangrajrang, Montserrat Garcia-Closas, James McKay, Alfons Meindl, Christoph Engel, Joe Dennis, Chiu-Chen Tseng, Catriona McLean, Arja Jukkola-Vuorinen, Peter A. Fasching, Katharina Heusinger, Georgia Chenevix-Trench, Robert A.E.M. Tollenaar, Kyriaki Michailidou, Rita K. Schmutzler, Shivaani Mariapun, Silje Nord, Hiltrud Brauch, Peter Devilee, Isabel dos-Santos-Silva, Douglas F. Easton, Frederik Marmé, Vilde D. Haakensen, Wei-Yen Lim, Keith Humphreys, Siddhartha Kar, Anja Rudolph, Arto Mannermaa, Jan Lubinski, Anna González-Neira, Sara Margolin, Matthias W. Beckmann, Simon S. Cross, Anne Lise Børresen-Dale, Jonine D. Figueroa, Alison M. Dunning, Kenneth Muir, Sander Canisius, Jingmei Li, Carmel Apicella, Jyh-Cherng Yu, Gertraud Maskarinec, Roger L. Milne, Henrik Flyger, Irene L. Andrulis, Annika Lindblom, Sofia Khan, Diana Torres, Clinical Genetics, Obstetrics & Gynecology, Medical Oncology, Surgery, Cardiothoracic Surgery, Pulmonary Medicine, Thompson, Deborah [0000-0003-1465-5799], Ghoussaini, Maya [0000-0002-2415-2143], Dennis, Joe [0000-0003-4591-1214], Wang, Jean [0000-0002-9139-0627], Luben, Robert [0000-0002-5088-6343], Khaw, Kay-Tee [0000-0002-8802-2903], Dunning, Alison [0000-0001-6651-7166], Easton, Douglas [0000-0003-2444-3247], and Apollo - University of Cambridge Repository

Subjects
Genotype, Quantitative Trait Loci, Autophagy-Related Proteins, Estrogen receptor, Breast Neoplasms, Genome-wide association study, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, White People, Article, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Asian People, SDG 3 - Good Health and Well-being, Odds Ratio, medicine, Genetics, Humans, SNP, Genetics(clinical), Luciferases, Genetics (clinical), 030304 developmental biology, Genetic association, 0303 health sciences, Chromosomes, Human, Pair 10, Haplotype, Age Factors, Chromosome Mapping, medicine.disease, 3. Good health, DNA-Binding Proteins, Enhancer Elements, Genetic, Gene Expression Regulation, 030220 oncology & carcinogenesis, Trans-Activators, Regression Analysis, Female, Genome-Wide Association Study, Transcription Factors
Abstract

Genome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association signal by genotyping 428 SNPs across the region in 89,050 European and 12,893 Asian case and control subjects from the Breast Cancer Association Consortium. We identified four independent sets of correlated, highly trait-associated variants (iCHAVs), three of which were located within ZNF365. The most strongly risk-associated SNP, rs10995201 in iCHAV1, showed clear evidence of association with both estrogen receptor (ER)-positive (OR = 0.85 [0.82-0.88]) and ER-negative (OR = 0.87 [0.82-0.91]) disease, and was also the SNP most strongly associated with percent mammographic density. iCHAV2 (lead SNP, chr10: 64,258,684:D) and iCHAV3 (lead SNP, rs7922449) were also associated with ER-positive (OR = 0.93 [0.91-0.95] and OR = 1.06 [1.03-1.09]) and ER-negative (OR = 0.95 [0.91-0.98] and OR = 1.08 [1.04-1.13]) disease. There was weaker evidence for iCHAV4, located 5' of ADO, associated only with ER-positive breast cancer (OR = 0.93 [0.90-0.96]). We found 12, 17, 18, and 2 candidate causal SNPs for breast cancer in iCHAVs 1-4, respectively. Chromosome conformation capture analysis showed that iCHAV2 interacts with the ZNF365 and NRBF2 (more than 600 kb away) promoters in normal and cancerous breast epithelial cells. Luciferase assays did not identify SNPs that affect transactivation of ZNF365, but identified a protective haplotype in iCHAV2, associated with silencing of the NRBF2 promoter, implicating this gene in the etiology of breast cancer.

Published
2015
Full Text
View/download PDF

214. Cigarette smoke inhalation and risk of lung cancer

Author

Toshiro Takezaki, Hidemi Ito, Kazuo Tajima, Keitaro Matsuo, Kohei Yokoi, Koichi Fukumoto, and Hideo Tanaka

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Epidemiology, Asian People, Risk Factors, Internal medicine, Statistical significance, medicine, Humans, Lung cancer, Aged, Aged, 80 and over, Smoke, Inhalation, business.industry, Smoking, Confounding, Public Health, Environmental and Occupational Health, Case-control study, Odds ratio, Middle Aged, medicine.disease, Confidence interval, Oncology, Case-Control Studies, Female, business
Abstract

Several studies have shown that cigarette smoke inhalation is associated with an increased risk of lung cancer (LC) in European populations. The aim of our study was to clarify the relationship between cigarette smoke inhalation and the risk of LC in a Japanese population. We carried out a large case-control study of cigarette smoking and the risk of LC in Japan. Cases were newly diagnosed patients with histologically confirmed LC (n=653). Controls (n=1281) included hospital controls (n=453) and community-based controls (n=828). Odds ratios (OR) and 95% confidence intervals (CI) were derived from unconditional logistic regression analysis, adjusted for basic confounding variables including age, sex, drinking status, fruit and vegetable intake, family history of LC, occupation, and years of education. Compared with never smokers, ORs for ever smokers who do not inhale cigarette smoke (noninhalation) and ever smokers who inhale cigarette smoke (inhalation) were 1.72 (95% CI: 1.15-2.59) and 3.28 (95% CI: 2.38-4.53), respectively, when adjusted for basic confounding variables. When the analysis was restricted to ever smokers, the OR adjusted for basic confounding factors and pack-year of the risk of LC in the inhalation group was significantly higher than that in the noninhalation group. OR for the inhalation group compared with the noninhalation group was 1.52 (95% CI: 1.06-2.18, P=0.021). A similar pattern was observed in subcategory analyses for adenocarcinoma, squamous cell carcinoma and small cell carcinoma, and other histological types, although without statistical significance. Our case-control study showed that inhalation of cigarette smoke is a significant risk for LC independent from pack-years in a Japanese population.

Published
2015

215. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

Author

Vesa Kataja, Aida Karina Dieffenbach, Chia-Ni Hsiung, Catherine S. Healey, Gie Hooi Tan, Soo Hwang Teo, Domenico Palli, Frederik Marme, Katri Pylkäs, Roger L. Milne, Jaana M. Hartikainen, Gord Glendon, Susan L. Slager, Chen-Yang Shen, Fredrick R. Schumacher, Daniel F. Schmidt, Suleeporn Sangrajrang, Kee Seng Chia, Lorna Gibson, Pascal Guénel, Alice S. Whittemore, Jenny Chang-Claude, Yu Tang Gao, Hidemi Ito, Simon S. Cross, Sofia Khan, Marie Sanchez, Daniel Vincent, Daniel Herrero, Nicola Miller, Antoinette Hollestelle, Caroline M. Seynaeve, Christopher A. Haiman, Hermann Brenner, Kay-Tee Khaw, Loris Bernard, Habibul Ahsan, Melissa C. Southey, David Van Den Berg, Martha J. Shrubsole, Daniel O. Stram, William Blot, Mel Maranian, Robert Winqvist, Keitaro Matsuo, John W. M. Martens, Heli Nevanlinna, Mia M. Gaudet, Anna Jakubowska, Christine D. Berg, Paul D.P. Pharoah, Jacques Simard, Manjeet K. Bolla, Dieter Flesch-Janys, Mark S. Goldberg, Paul Brennan, Ching Wan Chan, Sune F. Nielsen, Sara Lindström, Mitul Shah, Matthias W. Beckmann, Craig Luccarini, Jonathan Beesley, Kyriaki Michailidou, Paolo Peterlongo, Marc J. Gunter, Anna González-Neira, Ji Yeob Choi, Per Hall, Sarah Stewart-Brown, Keith Humphreys, Hui Cai, Kathleen E. Malone, Elinor J. Sawyer, Louise A. Brinton, Marjanka K. Schmidt, Xiao-Ou Shu, Barbara Perkins, Lotte Maxild Mortensen, Chiu-Chen Tseng, Hanne Meijers-Heijboer, Minouk J. Schoemaker, Keun-Young Yoo, Julia A. Knight, Alan Ashworth, Stig E. Bojesen, Kamila Czene, Artitaya Lophatananon, Graham G. Giles, S. Ahmed, Kazuo Tajima, Douglas F. Easton, Maria Kabisch, Arja Jukkola-Vuorinen, Wei Lu, Peter A. Fasching, Irene L. Andrulis, Clare Turnbull, Caroline Baynes, Christine B. Ambrosone, Jan Lubinski, Muriel A. Adank, A. Meindl, Taru A. Muranen, Siranoush Manoukian, Susan M. Gapstur, Natalia Bogdanova, Alexander Hein, Annika Lindblom, Nazneen Rahman, Annegien Broeks, Lothar Haeberle, Federico Canzian, G Pita, Ming-Feng Hou, Hiroji Iwata, Drakoulis Yannoukakos, Diana Torres, Vessela N. Kristensen, Peter Devilee, Qiuyin Cai, Christi J Asperen, John L. Hopper, Diether Lambrechts, Michael Lush, Hans Wildiers, Joe Dennis, Sandra L. Halverson, Carl Blomqvist, Erik Van Limbergen, Malin Sund, Daehee Kang, Grethe I. Grenaker Alnæs, Marilie D. Gammon, Ursula Eilber, Ian Tomlinson, Thérèse Truong, Amanda E. Toland, Anna Marie Mulligan, Kirsimari Aaltonen, Olivia Fletcher, Jonine D. Figueroa, Angela Cox, Pei Ei Wu, Maartje J. Hooning, Catriona McLean, Georgia Chenevix-Trench, Pornthep Siriwanarangsan, Malcolm W.R. Reed, Emily Hallberg, Sara Margolin, Volker Arndt, Montserrat Garcia-Closas, Francois Bacot, Rita K. Schmutzler, Julian Peto, David J. Hunter, Thomas Brüning, Katarzyna Jaworska, Christof Sohn, Børge G. Nordestgaard, Enes Makalic, Hatef Darabi, Barbara Burwinkel, Petra P.H. Peeters, J. Margriet Collée, Rongxi Yang, Robert N. Hoover, Eiliv Lund, Fergus J. Couch, Ute Hamann, Jirong Long, Wei Zheng, Sabine Behrens, Giske Ursin, Muhammad G. Kibriya, Claire Mulot, Laure Dossus, Helen Tsimiklis, Tomasz Huzarski, Peter Kraft, Anja Rudolph, Arto Mannermaa, Alison M. Dunning, Lisa B. Signorello, Valerie Gaborieau, Kenneth Muir, Anthony J. Swerdlow, Javier Benitez, Judith S. Brand, Sander Canisius, Hoda Anton-Culver, Veli-Matti Kosma, Thilo Dörk, Sten Cornelissen, Christa Stegmaier, Cheng Har Yip, Brian E. Henderson, Harald Surowy, Jingmei Li, Nur Aishah Taib, W. Ryan Diver, Carmel Apicella, Janet E. Olson, Kristiina Aittomäki, Celine M. Vachon, Regina M. Santella, Dimitrios Trichopoulos, Jianjun Liu, Nick Orr, Martine Dumont, Christian Sutter, Sue K. Park, Mikael Hartman, Susan L. Neuhausen, Hui Miao, M. Pilar Zamora, Anna H. Wu, Rob B. van der Luijt, Isabel dos-Santos-Silva, Graham Casey, Henrik Flyger, M. Rosario Alonso, Nuria Álvarez, Michael J. Kerin, Loic Le Marchand, Jose Ignacio Arias Perez, Mikael Eriksson, Esther M. John, Quinten Waisfisz, Qin Wang, Daniel C. Tessier, Paolo Radice, Robert A.E.M. Tollenaar, James McKay, Silje Nord, Hiltrud Brauch, José María Huerta, Stephen J. Chanock, Mervi Grip, Patrick Neven, Senno Verhoef, Clinical Genetics, Obstetrics & Gynecology, Medical Oncology, Cardiothoracic Surgery, Dennis, Joe [0000-0003-4591-1214], Wang, Jean [0000-0002-9139-0627], Khaw, Kay-Tee [0000-0002-8802-2903], Pharoah, Paul [0000-0001-8494-732X], Dunning, Alison [0000-0001-6651-7166], Easton, Douglas [0000-0003-2444-3247], Apollo - University of Cambridge Repository, Human genetics, and CCA - Oncogenesis

Subjects
Breast Neoplasms, Single-nucleotide polymorphism, Genome-wide association study, Biology, Research Support, Polymorphism, Single Nucleotide, N.I.H, Cohort Studies, brca1, Breast cancer, Research Support, N.I.H., Extramural, Meta-Analysis as Topic, SDG 3 - Good Health and Well-being, common variants, Journal Article, estrogen, chek2-asterisk-1100delc, Genetics, medicine, Humans, Genetic Predisposition to Disease, 1000 Genomes Project, Non-U.S. Gov't, genotype imputation, risk, Genetic association, Research Support, Non-U.S. Gov't, Chromatin binding, Extramural, Cancer, Microarray Analysis, confer susceptibility, medicine.disease, 3. Good health, ovarian-cancer, Genetic Loci, Case-Control Studies, alleles, Female, Imputation (genetics), Genome-Wide Association Study, metaanalysis
Abstract

Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1. ispartof: Nature Genetics vol:47 issue:4 pages:373-80 ispartof: location:United States status: published

Published
2015

216. Genetic polymorphisms of ADH1B, ADH1C and ALDH2, alcohol consumption, and the risk of gastric cancer: the Japan Public Health Center-based prospective study

Author

Akihisa, Hidaka, Shizuka, Sasazuki, Keitaro, Matsuo, Hidemi, Ito, Norie, Sawada, Taichi, Shimazu, Taiki, Yamaji, Motoki, Iwasaki, Manami, Inoue, Shoichiro, Tsugane, and S, Akiba

Subjects
Adult, Male, Risk, Cancer Research, medicine.medical_specialty, Alcohol Drinking, Polymorphism, Single Nucleotide, Gastroenterology, Japan, Stomach Neoplasms, Surveys and Questionnaires, Internal medicine, Genotype, Odds Ratio, Humans, Medicine, Prospective Studies, Prospective cohort study, Aged, Alcohol dehydrogenase, ALDH2, Genetics, Ethanol, biology, business.industry, Aldehyde Dehydrogenase, Mitochondrial, Alcohol Dehydrogenase, Case-control study, ADH1B, General Medicine, Odds ratio, Aldehyde Dehydrogenase, Middle Aged, Confidence interval, Case-Control Studies, biology.protein, Female, business
Abstract

The association between alcohol consumption, genetic polymorphisms of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) and gastric cancer risk is not completely understood. We investigated the association between ADH1B (rs1229984), ADH1C (rs698) and ALDH2 (rs671) polymorphisms, alcohol consumption and the risk of gastric cancer among Japanese subjects in a population-based, nested, case-control study (1990-2004). Among 36 745 subjects who answered the baseline questionnaire and provided blood samples, 457 new gastric cancer cases matched to 457 controls were used in the analysis. The odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated using logistic regression models. No association was observed between alcohol consumption, ADH1B (rs1229984), ADH1C (rs698) and ALDH2 (rs671) polymorphisms and gastric cancer risk. However, considering gene-environmental interaction, ADH1C G allele carriers who drink ≥150 g/week of ethanol had a 2.5-fold increased risk of gastric cancer (OR = 2.54, 95% CI = 1.05-6.17) relative to AA genotype carriers who drink 0 to

Published
2014

217. A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression

Author

Etsuko Ozaki, Chisato Shimanoe, Hidemi Ito, Yoichi Sutoh, Naoyuki Takashima, Kaori Endoh, Rieko Okada, Yukihide Momozawa, Yuichiro Nishida, Kokichi Arisawa, Rie Ibusuki, Tsuyoshi Hachiya, Megumi Hara, Miki Watanabe, Daisuke Matsui, Keitaro Matsuo, Atsushi Shimizu, Kiyonori Kuriki, Aya Kadota, Mariko Naito, Keitaro Tanaka, Asahi Hishida, Michiaki Kubo, Sadao Suzuki, Kenji Wakai, Sayo Kawai, Masahiro Nakatochi, H. Mikami, Takashi Tamura, Ippei Shimoshikiryo, Yusuke Nakamura, and Hirokazu Uemura

Subjects
0301 basic medicine, Adult, Male, Genome-wide association study, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Genetic variation, Adaptation, Psychological, Genetics, Humans, Emotional expression, Disengagement theory, Association (psychology), Gene, Aged, Polymorphism, Genetic, F-Box Proteins, Middle Aged, Expressed Emotion, 030104 developmental biology, Neurology, Female, Psychology, 030217 neurology & neurosurgery, Synapse maturation, Clinical psychology, Cohort study
Abstract

Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10-6 ) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10-6 ). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.

Published
2017

218. Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan

Author

Ikuko, Kashino, Shamima, Akter, Tetsuya, Mizoue, Norie, Sawada, Ayaka, Kotemori, Keitaro, Matsuo, Isao, Oze, Hidemi, Ito, Mariko, Naito, Tomio, Nakayama, Yuri, Kitamura, Akiko, Tamakoshi, Ichiro, Tsuji, Yumi, Sugawara, Manami, Inoue, Chisato, Nagata, Atsuko, Sadakane, Keitaro, Tanaka, Shoichiro, Tsugane, and Taichi, Shimazu

Subjects
Adult, Cohort Studies, Male, Japan, Incidence, Phytochemicals, Humans, Female, Middle Aged, Colorectal Neoplasms, Coffee, Aged, Proportional Hazards Models
Abstract

Coffee is a rich source of bioactive compounds that have potential anticarcinogenic effects. However, it remains unclear whether coffee drinking is associated with colorectal cancer. Also, despite different etiological factors involved in gut physiology, few studies have investigated this association by anatomical site of the lesion. To address these issues, this study examined the association between coffee drinking and colorectal cancer in a pooled analysis from 8 cohort studies conducted in Japan. Among 320,322 participants followed up for 4,503,274 person-years, 6,711 incident colorectal cancer cases were identified. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using the random effects model. Coffee drinking was not materially associated with colorectal cancer risk in men or women (pooled HR 0.92, 95% CI 0.82-1.03 in men and pooled HR 0.90, 95% CI 0.76-1.07 in women). Analysis by subsite showed a lower risk of colon cancer among female drinkers of ≥3 cups coffee/day (pooled HR 0.80, 95% CI 0.64-0.99). There was no such association in men. Coffee drinking was not associated with risk of rectal cancer in men or women. Results were virtually the same among never smokers except for an increased risk of rectal cancer associated with frequent coffee consumption. Coffee drinking may be associated with lower risk of colon cancer in Japanese women.

Published
2017

219. Evidence-based cancer prevention recommendations for Japanese

Author

Kenji Wakai, Hidemi Ito, Takeo Nakayama, Shoichiro Tsugane, Keitaro Tanaka, Yuri Kitamura, Manami Inoue, Yumi Sugawara, Ichiro Tsuji, T Mizoue, Mariko Naito, Taichi Shimazu, Atsuko Sadakane, Norie Sawada, Shizuka Sasazuki, Akiko Tamakoshi, Keitaro Matsuo, and Chisato Nagata

Subjects
Cancer Research, Evidence-based practice, Internationality, Alcohol Drinking, Health Planning Guidelines, MEDLINE, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Asian People, Japan, Meta-Analysis as Topic, Risk Factors, Environmental health, Neoplasms, Medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Exercise, Life Style, Cancer prevention, Evidence-Based Medicine, business.industry, Body Weight, Smoking, Cancer, General Medicine, Evidence-based medicine, medicine.disease, Diet, Oncology, 030220 oncology & carcinogenesis, Biological plausibility, business, Cohort study
Abstract

A comprehensive evidence-based cancer prevention recommendation for Japanese was developed. We evaluated the magnitude of the associations of lifestyle factors and infection with cancer through a systematic review of the literature, meta-analysis of published data, and pooled analysis of cohort studies in Japan. Then, we judged the strength of evidence based on the consistency of the associations between exposure and cancer and biological plausibility. Important factors were extracted and summarized as an evidence-based, current cancer prevention recommendation: 'Cancer Prevention Recommendation for Japanese'. The recommendation addresses six important domains related to exposure and cancer, including smoking, alcohol drinking, diet, physical activity, body weight and infection. The next step should focus on the development of effective behavior modification programs and their implementation and dissemination.

Published
2017

220. Heterogeneous impact of smoking on major salivary gland cancer according to histopathological subtype: A case-control study

Author

Michi, Sawabe, Hidemi, Ito, Taishi, Takahara, Isao, Oze, Daisuke, Kawakita, Yasushi, Yatabe, Yasuhisa, Hasegawa, Shingo, Murakami, and Keitaro, Matsuo

Subjects
Adult, Male, Carcinoma, Acinar Cell, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Smoking, Adenoma, Pleomorphic, Sublingual Gland Neoplasms, Adenocarcinoma, Middle Aged, Salivary Gland Neoplasms, Carcinoma, Adenoid Cystic, Parotid Neoplasms, Submandibular Gland Neoplasms, Head and Neck Neoplasms, Risk Factors, Case-Control Studies, Carcinoma, Squamous Cell, Odds Ratio, Tobacco Smoking, Humans, Carcinoma, Mucoepidermoid, Female, Aged
Abstract

Major salivary gland cancers (M-SGCs) are rare, and have distinct heterogeneous histopathological subtypes. To the authors' knowledge, no consistent evidence of an association between cigarette smoking and the risk of M-SGCs has appeared to date. Furthermore, evidence of potential heterogeneity in the impact of smoking on histopathological subtypes is scarce, despite the fact that the histopathological subtypes of M-SGC exhibit different genetic features.The authors conducted a case-control study to investigate the association between smoking and M-SGC by histopathological subtype. Cases were 81 patients with M-SGCs and the controls were 810 age-matched and sex-matched first-visit outpatients without cancer treated at Aichi Cancer Center Hospital from 1988 to 2005. Odds ratios (OR) and 95% confidence intervals (95% CI) were assessed by conditional logistic regression analysis with adjustment for potential confounders.Smoking was found to be associated with a significantly increased risk of M-SGC overall, with an OR of 3.45 (95% CI, 1.58-7.51; P =.001) for heavy smokers compared with never-smokers. A significant dose-response relationship was observed (P for trend, .001). When stratified by histological subtype, no obvious impact of smoking was observed among patients with mucoepidermoid carcinoma (MEC). In contrast, smoking demonstrated a significantly increased risk of M-SGCs other than MEC, with an OR of 5.15 (95% CI, 2.06-12.87; P.001) for heavy smokers compared with never-smokers. The authors observed possible heterogeneity with regard to the impact of smoking on risk between MEC and M-SGCs other than MEC (P for heterogeneity, .052).The results of the current study demonstrate a significant positive association between cigarette smoking and the risk of M-SGC overall. However, the impact of smoking appeared to be limited to M-SGCs other than MEC. Cancer 2018;124:118-24. © 2017 American Cancer Society.

Published
2017

221. Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians

Author

Jirong Long, Anna H. Wu, Cheng Har Yip, Mikael Hartman, Mi Ryung Han, Chiu-Chen Tseng, Ji Yeob Choi, Artitaya Lophatananon, Douglas F. Easton, Xiao-Ou Shu, Joe Dennis, Soo Hwang Teo, Hui Miao, Chen-Yang Shen, Suleeporn Sangrajrang, Paul Brennan, Alison M. Dunning, Hidemi Ito, Qiuyin Cai, Kenneth Muir, Kyriaki Michailidou, Yu-Tang Gao, Qin Wang, Shou Tung Chen, Ying Zheng, Daehee Kang, Yong-Bing Xiang, Wei Zheng, Keitaro Matsuo, and Manjeet K. Bolla

Subjects
0301 basic medicine, Oncology, Risk, Asian Continental Ancestry Group, Cancer Research, medicine.medical_specialty, PALB2, Oncology and Carcinogenesis, Single-nucleotide polymorphism, Original Manuscript, Breast Neoplasms, Penetrance, Polymorphism, Single Nucleotide, 03 medical and health sciences, Databases, Breast cancer, Asian People, Gene Frequency, Genetic, Internal medicine, Databases, Genetic, medicine, Journal Article, Humans, Genetic Predisposition to Disease, Oncology & Carcinogenesis, Polymorphism, skin and connective tissue diseases, CHEK2, Alleles, Genetic Association Studies, Gynecology, business.industry, Chromosome Mapping, Genetic Variation, General Medicine, Single Nucleotide, medicine.disease, Minor allele frequency, 030104 developmental biology, Population Surveillance, RAD51C, Female, Breast Cancer Genetics, business
Abstract

Over the past 20 years, high-penetrance pathogenic mutations in genes BRCA1, BRCA2, TP53, PTEN, STK11 and CDH1 and moderate-penetrance mutations in genes CHEK2, ATM, BRIP1, PALB2, RAD51C, RAD50 and NBN have been identified for breast cancer. In this study, we investigated whether there are additional variants in these 13 genes associated with breast cancer among women of Asian ancestry. We analyzed up to 654 single nucleotide polymorphisms (SNPs) from 6269 cases and 6624 controls of Asian descent included in the Breast Cancer Association Consortium (BCAC), and up to 236 SNPs from 5794 cases and 5529 controls included in the Shanghai Breast Cancer Genetics Study (SBCGS). We found three missense variants with minor allele frequency (MAF)

Published
2017

222. Association between coffee consumption and all-sites cancer incidence and mortality

Author

Hidemi Ito, Yuri Kitamura, Suketami Tominaga, Tetsuhisa Kitamura, Takaichiro Suzuki, Hideo Tanaka, Tomotaka Sobue, Tomio Nakayama, Kota Katanoda, Ichiro Tsuji, Yoshikazu Nishino, and Junya Sado

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Population, 03 medical and health sciences, 0302 clinical medicine, Caffeine, Neoplasms, Surveys and Questionnaires, Epidemiology, cancer mortality, Medicine, Humans, 030212 general & internal medicine, Prospective Studies, education, Aged, Proportional Hazards Models, coffee consumption, education.field_of_study, business.industry, Incidence, Hazard ratio, Confounding, Cancer, Epidemiology and Prevention, General Medicine, Original Articles, cohort, Middle Aged, medicine.disease, Oncology, Cancer incidence, 030220 oncology & carcinogenesis, Cohort, Female, Original Article, epidemiology, business, Cohort study, Demography
Abstract

The preventive effect of coffee on cancer at different sites has been reported, but the effect on all-sites cancer incidence has not been extensively investigated. We evaluated the association between frequency of coffee consumption and risk of all-sites cancer incidence and mortality among 39 685 men and 43 124 women (age 40–79 years, at baseline), in the Three-Prefecture Cohort Study. The association between frequency of coffee consumption and risk of all-sites cancer incidence and mortality was assessed by a Cox proportional hazards regression model, adjusted for potential confounders. During 411 341 person-years among men and 472 433 person-years among women, a total of 4244 men and 2601 women developed cancer at different sites and a total of 3021 men and 1635 women died of cancer at different sites. We showed an inverse association between frequency of coffee consumption and all-sites cancer incidence in both men and women. Comparing participants who consumed coffee with those who never drank coffee, the adjusted hazard ratios (95% confidential interval) for all-sites cancer incidence was 0.74 (0.62–0.88) for coffee consumption of ≥5 cups/day in men (P for trend

Published
2017

223. Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study

Author

Javier Benitez, Sara Margolin, Diether Lambrechts, Alexandra J. van den Broek, Chen-Yang Shen, Veli-Matti Kosma, Matthias W. Beckmann, Siranoush Manoukian, Antoinette Hollestelle, Montserrat Garcia-Closas, Paul Brennan, Chiu-Chen Tseng, Marjanka K. Schmidt, Carolien H.M. van Deurzen, Peter A. Fasching, Melissa C. Southey, Manjeet K. Bolla, Robert Winqvist, Keitaro Matsuo, Douglas F. Easton, Carl Blomqvist, Adelheid Soubry, Paul D.P. Pharoah, Pascal Guénel, Jenna Lilyquist, Anna González-Neira, Hidemi Ito, Daehee Kang, Thérèse Truong, Fergus J. Couch, Renske Keeman, Kenneth Muir, Caroline Seynaeve, Katri Pylkäs, Simon S. Cross, Per Hall, Olivier Brouckaert, Roger L. Milne, Cheng Har Yip, Qin Wang, Sten Cornelissen, Anja Rudolph, Kamila Czene, Artitaya Lophatananon, Mikael Eriksson, Xiao-Ou Shu, Jonine D. Figueroa, Julia A. Knight, Arto Mannermaa, Jyh-Cherng Yu, Hans Wildiers, John L. Hopper, Wei Zheng, Jingmei Li, Rob A. E. M. Tollenaar, Anthony J. Swerdlow, Hermann Brenner, Henrik Flyger, Patrick Neven, Georgia Chenevix-Trench, Irene L. Andrulis, Paolo Peterlongo, Ji Yeob Choi, Annouschka Laenen, Annika Lindblom, Hiltrud Brauch, Anna H. Wu, Heli Nevanlinna, Michael Jones, Angela Cox, Volker Arndt, Soo-Hwang Teo, Jenny Chang-Claude, Stig E. Bojesen, Graham G. Giles, Suleeporn Saajrang, School of Medicine / Clinical Medicine, Wang, Jean [0000-0002-9139-0627], Benitez, Javier [0000-0002-0923-7202], Blomqvist, Carl [0000-0003-3041-1938], Brauch, Hiltrud [0000-0001-7531-2736], Brenner, Hermann [0000-0002-6129-1572], Chenevix-Trench, Georgia [0000-0002-1878-2587], Cox, Angela [0000-0002-5138-1099], Eriksson, Mikael [0000-0001-8135-4270], González-Neira, Anna [0000-0002-5421-2020], Guénel, Pascal [0000-0002-8359-518X], Jones, Michael [0000-0001-7479-3451], Li, Jingmei [0000-0001-8587-7511], Matsuo, Keitaro [0000-0003-1761-6314], Peterlongo, Paolo [0000-0001-6951-6855], Pylkäs, Katri [0000-0002-2449-0521], Southey, Melissa C [0000-0002-6313-9005], Swerdlow, Anthony [0000-0001-5550-4159], Truong, Thérèse [0000-0002-2943-6786], Pharoah, Paul [0000-0001-8494-732X], Easton, Douglas [0000-0003-2444-3247], Lambrechts, Diether [0000-0002-3429-302X], Apollo - University of Cambridge Repository, Medical Oncology, Pathology, Department of Oncology, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, HUS Comprehensive Cancer Center, Unión Europea. Comisión Europea. 7 Programa Marco, Cancer Research UK (Reino Unido), NIH - National Cancer Institute (NCI) (Estados Unidos), National Health and Medical Research Council (Australia), New South Wales Cancer Council (Reino Unido), Victorian Health Promotion Foundation, Dutch Cancer Society (Holanda), Agence Nationale de la Recherche (Francia), French Agency for Food, Environmental and Occupational Health & Safety (Francia), Asociación Española Contra el Cáncer, Instituto de Salud Carlos III, Centro de Investigación Biomedica en Red - CIBER, Federal Ministry of Education & Research (Alemania), Cancer Society of Finland, Ministry of Education, Culture, Sports, Science, and Technology (Japón), Japan Agency for Medical Research and Development, United States Army Medical Research and Development Command, California Breast Cancer Research Program, German Cancer Aid, Ministry of Higher Education (Malasia), Biomedical Research Council (Singapore), National Institutes of Health (Estados Unidos), and National Research Foundation of Korea

Subjects
0301 basic medicine, Oncology, Triple Negative Breast Neoplasms, Cohort Studies, 0302 clinical medicine, HORMONE-RECEPTOR STATUS, Medizinische Fakultät, Risk Factors, Odds Ratio, Young adult, Reproductive History, POPULATION, Age at menarche, education.field_of_study, WOMEN, ASSOCIATION, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Parity, PREGNANCY, 030220 oncology & carcinogenesis, Age at breast cancer diagnosis, kConFab, Menarche, Female, Cohort study, Research Article, Adult, medicine.medical_specialty, 3122 Cancers, Population, Breast Neoplasms, DIAGNOSIS, lcsh:RC254-282, Risk Assessment, MENARCHE, 1ST BIRTH, 03 medical and health sciences, Young Adult, AGE, Breast cancer, SDG 3 - Good Health and Well-being, Internal medicine, Journal Article, medicine, Biomarkers, Tumor, Humans, ddc:610, education, Aged, Gynecology, Pregnancy, business.industry, Odds ratio, medicine.disease, 030104 developmental biology, Age at first full-time pregnancy, Breast cancer subtype, business
Abstract

Background Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. Methods We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years. Results Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16–1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0.030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01–2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45–1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70–0.88, p, published version, peerReviewed

Published
2017

224. Association analysis identifies 65 new breast cancer risk loci

Author

Michael Jones, Dong-Young Noh, Martha J. Shrubsole, Chen-Yang Shen, Xiaoqing Chen, Esther M. John, Patricia Harrington, Quinten Waisfisz, Sue K. Park, Miriam Dwek, Christa Stegmaier, Sibylle Loibl, Wing-Yee Lo, Suleeporn Sangrajrang, Susan L. Neuhausen, Marina Bermisheva, Alicja Wolk, Christof Sohn, Keun-Young Yoo, Arja Jukkola-Vuorinen, Kathrin Thöne, James McKay, John J. Spinelli, Brian D. Carter, Elza Khusnutdinova, Francois Bacot, Paul L. Auer, Anna H. Wu, Christopher I. Amos, Johanna I. Kiiski, Hans Wildiers, Manjeet K. Bolla, Soo Hwang Teo, Julie M. Cunningham, Zhaoming Wang, Dieter Flesch-Janys, Argyrios Ziogas, Ann Smeets, Min Hyuk Lee, Xiaohong R. Yang, Carl Blomqvist, Natalia Antonenkova, Vassilios Georgoulias, Siranoush Manoukian, Anne Lise Børresen-Dale, Montserrat Garcia-Closas, Priyanka Sharma, Michael J. Kerin, Loic Le Marchand, Yoshio Kasuga, Michael Untch, Thomas Brüning, Natalia Bogdanova, Juliet D. French, Mark E. Sherman, Diana Eccles, Don M. Conroy, Marcia Adams, Pascal Guénel, Jonine D. Figueroa, Somchai Thanasitthichai, Jonathan Beesley, Paolo Peterlongo, Angela Cox, Graham G. Giles, Hans Christiansen, Irene L. Andrulis, Caroline Baynes, V. Shane Pankratz, Kristine Jones, Wei Zheng, Motoki Iwasaki, Rita K. Schmutzler, Julian Peto, Sara Margolin, Hedy S. Rennert, Hidemi Ito, Caroline Seynaeve, Jirong Long, Rachel Lloyd, Mark S. Goldberg, Javier Benitez, Børge G. Nordestgaard, Kathleen E. Malone, A. Heather Eliassen, Valerie Rhenius, Kristan J. Aronson, Maartje J. Hooning, Ursula Eilber, Christopher A. Haiman, Ji Yeob Choi, Jaana M. Hartikainen, Ian W. Brock, Barbara Burwinkel, Brigitte Rack, Mitul Shah, Matthias W. Beckmann, Belynda Hicks, Bernardo Bonanni, Alexander Hein, Leslie Bernstein, Christine L. Clarke, Emilie Cordina-Duverger, Sabine Behrens, Hoda Anton-Culver, Angela Brooks-Wilson, Bin Zhu, Gord Glendon, Banu Arun, José A. García-Sáenz, Jose Ignacio Arias Perez, Anne Grundy, Ans M.W. van den Ouweland, Nadege Presneau, Volker Arndt, Mikael Eriksson, Simon S. Cross, Craig Luccarini, Anthony J. Swerdlow, Veli-Matti Kosma, Hui Miao, Ming-Feng Hou, Hiroji Iwata, Christi J. van Asperen, Henrik Flyger, Jennifer Stone, Qin Wang, Penny Soucy, Heli Nevanlinna, Jane Heyworth, Shoichiro Tsugane, Annika Lindblom, Curtis Olswold, Trinidad Caldés, Laura Fachal, Ed Dicks, Shirley Hui, Katja Butterbach, Alison M. Dunning, Peter Devilee, Qiuyin Cai, Antonis C. Antoniou, Diether Lambrechts, Katarzyna Kaczmarek, Katri Pylkäs, Fredrick R. Schumacher, Arif B. Ekici, Aaron D. Norman, Jolanta Lissowska, Daniel C. Tessier, N Hamel, Paolo Radice, Håkan Olsson, Vessela N. Kristensen, Ling Tong, Harald Surowy, Rulla M. Tamimi, Jonathan Tyrer, Michael P. Lux, Stacey L. Edwards, Kathryn J. Ruddy, Giske Ursin, Myrto Barrdahl, Xiao-Ou Shu, Primitiva Menéndez, Sara Y. Brucker, Elad Ziv, Kenneth Muir, Eric Hahnen, Andy C. H. Lee, Rodney J. Scott, Lothar Haeberle, Darya Prokofyeva, Isabel dos-Santos-Silva, Peter Kraft, David G. Cox, Jong Won Lee, Sunil R. Lakhani, Kelly-Anne Phillips, Douglas F. Easton, Melissa C. Southey, Jan Lubinski, Jose E. Castelao, Hanne Meijers-Heijboer, Ivana Maleva Kostovska, Siddhartha Kar, Renske Keeman, Celine M. Vachon, Diana Torres, Stephen J. Chanock, Jack A. Taylor, Emiel J. Th. Rutgers, Chuen Neng Lee, Jason Vollenweider, Gadi Rennert, Jane Romm, Amy E. McCart Reed, Kee Seng Chia, Thomas Rüdiger, Anja Rudolph, Catriona McLean, David Van Den Berg, Christopher G. Scott, Mervi Grip, Lucy Xia, Georgia Chenevix-Trench, Robert Winqvist, Mary Beth Terry, Jenny Chang-Claude, Hans-Ulrich Ulmer, Mikael Hartman, Dona N. Ho, Maria Kabisch, Christoph Engel, Claire Mulot, Grethe I. Grenaker Alnæs, Arto Mannermaa, Nazneen Rahman, Tjoung-Won Park-Simon, Atocha Romero, Lin Fritschi, Manuela Gago-Dominguez, Matthias Ruebner, Valerie Gaborieau, Keitaro Matsuo, Asha Rostamianfar, Emmanouil Saloustros, Dijana Plaseska-Karanfilska, J.-P. Meyer, Sara Lindström, Annegien Broeks, Audrey Lemaçon, Tsun Leung Chan, Tongguang Cheng, Robert J. MacInnis, Habibul Ahsan, Federico Canzian, Paul Brennan, Mia M. Gaudet, David E. Goldgar, Anna Jakubowska, Paul D.P. Pharoah, Jacek Gronwald, Sung-Won Kim, Daehee Kang, Daniel O. Stram, Nichola Johnson, Rob B. van der Luijt, Sten Cornelissen, Camilla Wendt, Dylan M. Glubb, Olufunmilayo I. Olopade, Usha Menon, David J. Hunter, Kristiina Aittomäki, Jamie Allen, Chiu-Chen Tseng, Keith Humphreys, Edmond S. K. Ma, Peter Hillemanns, Hiltrud Brauch, Chia-Ni Hsiung, Sheila Seal, Junko Ishiguro, Dale P. Sandler, Peter Schürmann, Gary D. Bader, Sarah Stewart-Brown, Flavio Lejbkowicz, Marike Gabrielson, Wolfgang Janni, Judith S. Brand, Jingmei Li, Ava Kwong, Stig E. Bojesen, Ying Zheng, Mila Pinchev, Yu Tang Gao, Susan E. Hankinson, Elinor J. Sawyer, Per Broberg, Sofia Khan, Grace Sheng, Alfons Meindl, Margriet Collée, Jyh-Cherng Yu, Ute Krüger, Louise A. Brinton, Elizabeth W. Pugh, Thilo Dörk, Hilary K. Finucane, Peter A. Fasching, Shan Wang-Gohrke, Jenna Lilyquist, Muriel A. Adank, Marjanka K. Schmidt, Susan M. Gapstur, Sune F. Nielsen, Maya Ghoussaini, Minouk J. Schoemaker, Roger L. Milne, Jacques Simard, Clarice R. Weinberg, Kyriaki Michailidou, Shivaani Mariapun, Rob A. E. M. Tollenaar, Lizet E. van der Kolk, Nicola Miller, Anna González-Neira, Ian Tomlinson, Thérèse Truong, Ross L. Prentice, Anna Marie Mulligan, Jason S. Carroll, Taiki Yamaji, Carolina Ellberg, Mingajeva Elvira, Olivia Fletcher, Arnaud Droit, Per Hall, Maria Elena Martinez, Maria Tengström, Hui Cai, Xia Jiang, Janet E. Olson, Julia A. Knight, Nick Orr, Angel Carracedo, Guanmengqian Huang, Martine Dumont, Cheng Har Yip, Tom Maishman, Mary B. Daly, Artitaya Lophatananon, Niclas Håkansson, Steven N. Hart, Nur Aishah Taib, Andreas Schneeweiss, Daniel F. Schmidt, Daniel Vincent, Antoinette Hollestelle, Dimitrios Mavroudis, JoAnn E. Manson, Joe Dennis, Walter C. Willett, Rudolf Kaaks, Karen McCue, Enes Makalic, Kimberly F. Doheny, Eunjung Lee, Robert N. Hoover, Fergus J. Couch, Ute Hamann, Alice S. Whittemore, Hermann Brenner, Lorraine Durcan, Kamila Czene, Patrick Neven, John L. Hopper, Clinical Genetics, Medical Oncology, Human Genetics, CCA - Cancer biology and immunology, Dennis, Joe [0000-0003-4591-1214], Wang, Jean [0000-0002-9139-0627], Tyrer, Jonathan [0000-0003-3724-4757], Dicks, Ed [0000-0002-0617-0401], Lee, Andrew [0000-0003-0677-0252], Allen, Jamie [0000-0002-8677-2225], Fachal Vilar, Laura [0000-0002-7256-9752], Carroll, Jason [0000-0003-3643-0080], Rhenius, Valerie [0000-0003-4215-3235], Antoniou, Antonis [0000-0001-9223-3116], Pharoah, Paul [0000-0001-8494-732X], Dunning, Alison [0000-0001-6651-7166], Easton, Douglas [0000-0003-2444-3247], Apollo - University of Cambridge Repository, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, and Amsterdam Reproduction & Development (AR&D)

Subjects
0301 basic medicine, Multifactorial Inheritance, Genome-wide association study, Regulatory Sequences, Nucleic Acid, skin and connective tissue diseases, Cancer genetics, Genetics, Multidisciplinary, medicine.diagnostic_test, 3. Good health, Europe, annotation, Medical genetics, Female, Asian Continental Ancestry Group, medicine.medical_specialty, Asia, architecture, European Continental Ancestry Group, ABCTB Investigators, Locus (genetics), Breast Neoplasms, Biology, Polymorphism, Single Nucleotide, Risk Assessment, Article, White People, NBCS Collaborators, 03 medical and health sciences, Breast cancer, Asian People, SDG 3 - Good Health and Well-being, Genetic variation, ConFab/AOCS Investigators, expression, medicine, Genetic predisposition, Journal Article, Humans, Computer Simulation, Genetic Predisposition to Disease, biological pathways, Genetic association, Genetic testing, Genetic association study, Binding Sites, interaction networks, medicine.disease, comprehensive molecular portraits, mutations, susceptibility loci, 030104 developmental biology, Genetic Loci, genome-wide association, protein, Transcription Factors, Genome-Wide Association Study
Abstract

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P

Published
2017

225. Long‐term survival and conditional survival of cancer patients in Japan using population‐based cancer registry data

Author

Masashi Matsuzaka, Kayo Nakata-Yamada, Isao Oze, Hidemi Ito, Masakazu Hattori, Yoshikazu Nishino, Satoyo Hosono, Yuri Ito, Hiromi Sugiyama, Isao Miyashiro, Akiko Ioka, Masashi Nakayama, Rina Tanaka, Tomio Nakayama, Etsuko Nomura, Hideaki Tsukuma, Tomohiro Matsuda, and Dai Chihara

Subjects
Male, Oncology, Gerontology, Cancer Research, medicine.medical_specialty, Population, survival, period analysis, Japan, Neoplasms, Internal medicine, Pancreatic cancer, Epidemiology of cancer, medicine, cancer registry, Humans, Registries, education, Thyroid cancer, Cancer, education.field_of_study, conditional survival, Relative survival, business.industry, Age Factors, Original Articles, General Medicine, medicine.disease, Cancer registry, Population Surveillance, Female, Liver cancer, business, Follow-Up Studies
Abstract

Although we usually report 5-year cancer survival using population-based cancer registry data, nowadays many cancer patients survive longer and need to be followed-up for more than 5 years. Long-term cancer survival figures are scarce in Japan. Here we report 10-year cancer survival and conditional survival using an established statistical approach. We received data on 1,387,489 cancer cases from six prefectural population-based cancer registries in Japan, diagnosed between 1993 and 2009 and followed-up for at least 5 years. We estimated the 10-year relative survival of patients who were followed-up between 2002 and 2006 using period analysis. Using this 10-year survival, we also calculated the conditional 5-year survival for cancer survivors who lived for some years after diagnosis. We reported 10-year survival and conditional survival of 23 types of cancer for 15-99-year-old patients and four types of cancer for children (0-14 years old) and adolescent and young adults (15-29 years old) patients by sex. Variation in 10-year cancer survival by site was wide, from 5% for pancreatic cancer to 95% for female thyroid cancer. Approximately 70-80% of children and adolescent and young adult cancer patients survived for more than 10 years. Conditional 5-year survival for most cancer sites increased according to years, whereas those for liver cancer and multiple myeloma did not increase. We reported 10-year cancer survival and conditional survival using population-based cancer registries in Japan. It is important for patients and clinicians to report these relevant figures using population-based data.

Published
2014

226. Stroke mortality associated with environmental tobacco smoke among never-smoking Japanese women: A prospective cohort study

Author

Haruo Nakatsuka, Hidemi Ito, Tomio Nakayama, Takaichiro Suzuki, Ichiro Tsuji, Hideo Tanaka, Tomotaka Sobue, Yoshikazu Nishino, Suketami Tominaga, and Kota Katanoda

Subjects
Adult, medicine.medical_specialty, Subarachnoid hemorrhage, Epidemiology, Risk Assessment, Tobacco smoke, Cohort Studies, Japan, Internal medicine, medicine, Humans, Prospective Studies, Prospective cohort study, Stroke, Aged, Aged, 80 and over, business.industry, Smoking, Confounding, Hazard ratio, Public Health, Environmental and Occupational Health, Environmental Exposure, Middle Aged, medicine.disease, Confidence interval, Surgery, Population study, Female, Tobacco Smoke Pollution, business
Abstract

Objective This study examined the association of exposure to environmental tobacco smoke (ETS) during adulthood with stroke and its subtypes using data from a large-scale prospective cohort study in Japan. Methods The study population included 36,021 never-smoking Japanese women who were enrolled between 1983 and 1985 and were followed-up for 15 years. We used Cox proportional hazard regression models to estimate hazard ratios (HRs) for stroke death associated with ETS exposure at home during adulthood. Results A total of 906 cases of stroke death were observed during 437,715 person-years of follow-up. Compared with never-smoking women without smoking family members, HRs for stroke mortality among never-smoking women living with smoking family members in all subjects, in those aged 40–79 years, and in those aged ≥ 80 years were 1.14 (95% confidence interval: 0.99–1.31), 1.24 (95% CI: 1.05–1.46), and 0.89 (95% CI: 0.66–1.19), respectively, after adjustment for possible confounders. The risk was most evident for subarachnoid hemorrhage [HR: 1.66 (95% CI: 1.02–2.70) in all subjects]. Conclusion This study suggests that exposure to ETS at home during adulthood is associated with an increased risk of stroke among never-smoking Japanese women.

Published
2014

227. Impact of metallothionein gene polymorphisms on the risk of lung cancer in a Japanese population

Author

Hidemi Ito, Fumihiko Matsuda, Keitaro Matsuo, Satoyo Hosono, Isao Oze, Hideo Nakane, Hideo Tanaka, and Minoru Hirano

Subjects
Oncology, Genetics, Cancer Research, medicine.medical_specialty, Confounding, Case-control study, Single-nucleotide polymorphism, Odds ratio, Biology, Logistic regression, medicine.disease, Confidence interval, Internal medicine, medicine, Gene–environment interaction, Lung cancer, Molecular Biology
Abstract

Metallothioneins (MTs) are cysteine-rich proteins that act as antioxidants. A case-control study was conducted to assess the effects of gene polymorphisms in the MT region on the risk of lung cancer in Japanese subjects: 769 lung cancer cases and 939 non-cancer controls. Associations were evaluated using logistic regression models with adjustment for potential confounders (age, sex, and lifestyle factors including smoking, drinking, and green-yellow vegetable intake). We found five polymorphisms in the MT-1 gene region that showed statistically significant associations with lung cancer. Of these polymorphisms, rs7196890 showed the strongest association (odds ratio: 1.30, P = 0.004, 95% confidence interval: 1.09–1.55). The impact of the polymorphism decreased with the increase of smoking, and virtually no association with lung cancer was observed among heavy smokers whose pack-year values were 30 or more (odds ratio: 1.02, P = 0.93, 95% confidence interval: 0.67–1.55). These results suggest that polymorphisms in the MT gene are moderately associated with the risk of lung cancer and that the associations are modified by lifestyle factors. © 2014 Wiley Periodicals, Inc.

Published
2014

228. Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1

Author

Siew-Kee Low, Wei Lu, Min Ho Park, Yoshio Kasuga, Jiemin Liao, Sei Hyun Ahn, Ji Yeob Choi, Hyuna Sung, Michiaki Kubo, Bingshan Li, Kyota Ashikawa, Yanfeng Zhang, Hidemi Ito, Koichi Matsuda, Chen-Yang Shen, Ryan J. Delahanty, Bu Tian Ji, Yu-Tang Gao, Han Sung Kang, Yusuke Nakamura, Motoki Iwasaki, Hiroji Iwata, Chia-Ni Hsiung, Mi Kyung Kim, Ying Zheng, Ellen P S Man, Daehee Kang, Ui-Soon Khoo, Soo Hwang Teo, Xiao-Ou Shu, Yong-Bing Xiang, Wanqing Wen, Jiajun Shi, Wei Zheng, Chun Li, Shoichiro Tsugane, Keitaro Matsuo, Hui Miao, Peter B. Kang, Pei-Ei Wu, Qiuyin Cai, Sue K. Park, Kelvin Y.K. Chan, Dong-Young Noh, Jirong Long, Shivaani Mariapun, Ben Zhang, Sun-Seog Kweon, Atsushi Takahashi, Mikael Hartman, and Min-Ho Shin

Subjects
Adult, Risk, Breast Neoplasms, Genome-wide association study, Biology, White People, Article, Breast cancer, Asian People, Genetics, medicine, Genome-Wide Association Analysis, Humans, Genetic Predisposition to Disease, skin and connective tissue diseases, Genetic association, Chromosomes, Human, Pair 15, Asia, Eastern, Case-control study, Middle Aged, medicine.disease, 3. Good health, Chromosomes, Human, Pair 1, Genetic Loci, Case-Control Studies, Susceptibility locus, Chromosomes, Human, Pair 5, Female, Genome-Wide Association Study
Abstract

In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified three novel genetic loci associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene, P = 8.82 × 10−9), rs10474352 at 5q14.3 (near the ARRDC3 gene, P = 1.67 × 10−9), and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene, P = 4.25 × 10−8). These associations were replicated in European-ancestry populations including 16,003 cases and 41,335 controls (P = 0.030, 0.004, and 0.010, respectively). Data from the ENCODE project suggest that variants rs4951011 and rs10474352 may be located in an enhancer region and transcription factor binding sites, respectively. This study provides additional insights into the genetics and biology of breast cancer.

Published
2014

229. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Hidemi Ito, Stephen K. Van Den Eeden, Abdisamad M. Ibrahim, Ching C. Lau, Preetha Rajaraman, Gloria M. Petersen, Judith Hoffman-Bolton, Colin P.N. Dinney, Chang Hyun Kang, Melinda C. Aldrich, Mark P. Purdue, Xiao-Ou Shu, William J. Blot, Sanjay Shete, Alpa V. Patel, Charles Kooperberg, Paolo Vineis, David Van Den Berg, Chao A. Hsiung, Anthony J. Swerdlow, Qing Lan, Wu Chou Su, Afshan Siddiq, Ulrike Peters, Katia Scotlandi, Sara H. Olson, Kendra Schwartz, Kelly L. Bolton, Chancellor Hohensee, Josep Lloreta, Kevin B. Jacobs, Debra T. Silverman, Rudolf Kaaks, Wei Zheng, Steven Gallinger, Junwen Wang, Angela Carta, Massimo Serra, Petra H.M. Peeters, Victoria L. Stevens, Yasushi Yatabe, Geraldine Cancel-Tassin, Joshua N. Sampson, Young Tae Kim, Graham A. Colditz, Pan-Chyr Yang, Baosen Zhou, Fredrick R. Schumacher, Nicolas Wentzensen, Evelyn Tay, Claudia Maria Hattinger, Chen Wu, Pilar Amiano, Mattias Johansson, Maxwell P. Lee, Christian P. Kratz, Michael B. Cook, Mingfeng Zhang, Kay-Tee Khaw, Jian-Min Yuan, Anne Zeleniuch-Jacquotte, Jinping Jia, Roberto Tirabosco, Jing Ma, Neil E. Caporaso, Christopher A. Haiman, Bu Tian Ji, Adrienne M. Flanagan, Neyssa Marina, Eric J. Jacobs, Sophia S. Wang, Chong-Jen Yu, Edward Giovannucci, Margaret Wrensch, Robert L. Grubb, Bin Zhu, Daniel O. Stram, Manolis Kogevinas, Margaret R. Karagas, Mazda Jenab, Alison M. Mondul, Jun Xu, Preethi S. Raj, Anders Ahlbom, Christine D. Berg, Shelley Niwa, Kala Visvanathan, Loic Le Marchand, Jorge R. Toro, Robert N. Hoover, Heather Spencer Feigelson, Michelle Brotzman, Laurence N. Kolonel, Krista A. Zanetti, Chengfeng Wang, Mary Ann Butler, Ann Truelove, Irene L. Andrulis, Hongbing Shen, H. Dean Hosgood, Ming Shyan Huang, Gee-Chen Chang, Jianjun Liu, John K. Wiencke, Stephanie J. Weinstein, Beatrice Melin, Kouya Shiraishi, Zhihua Yin, Lee E. Moore, Börje Ljungberg, Jolanta Lissowska, Elizabeth M. Gillanders, M. T. Landi, Cari M. Kitahara, Maria Feychting, Kuan-Yu Chen, Matthias Simon, Brian M. Wolpin, Hemang Parikh, Hannah P. Yang, Graham G. Giles, Alison Johnson, Demetrius Albanes, Carlos González, Brian E. Henderson, Xifeng Wu, Harvey A. Risch, Amy Hutchinson, Christopher Hautman, Constance Chen, Zhibin Hu, Donghui Li, Elio Riboli, Julie E. Buring, Curtis C. Harris, Xu Che, Núria Malats, Roger Henriksson, Rosario Tumino, Joanne S. Colt, Alfredo Carrato, Paolo Boffetta, Maria Pik Wong, Hideo Tanaka, Federico Canzian, Alan D. L. Sihoe, Chien-Jen Chen, Kenneth Muir, Chen Ying, Qincheng He, Melissa C. Southey, Marc Sanson, Victoria K. Cortessis, Sharon A. Savage, Wei Hu, Yao Tettey, Daniela S. Gerhard, Sofia Pavanello, Guangwen Cao, H. Barton Grossman, Michael Goggins, Hideo Kunitoh, Peter D. Inskip, Seth P. Lerner, Peter Kraft, David Thomas, Peng Guan, Chung Hsing Chen, I. Shou Chang, Christoffer Johansen, Roberta McKean-Cowdin, Lee J. Helman, Yuh Min Chen, Ana Patiño-García, Pär Stattin, Xiaoping Miao, Tangchun Wu, Jay S. Wunder, Ann W. Hsing, Yu-Tang Gao, Brooke L. Fridley, Tania Carreón, Charles C. Chung, Nan Hu, Yoo Jin Jung, Richard B. Biritwum, Eric J. Duell, Philip R. Taylor, Satu Männistö, Kai Yu, Meredith Yeager, Xia Pu, Vittorio Krogh, Anand P. Chokkalingam, Susan M. Gapstur, W. Ryan Diver, Yuanqing Ye, Keitaro Matsuo, Cecilia Arici, You-Lin Qiao, Alan R. Schned, Dominique S. Michaud, Joanne W. Elena, Christopher Kim, Dongxin Lin, Yun-Chul Hong, Daru Lu, Reina García-Closas, Jonine D. Figueroa, Linda M. Liao, Yi-Long Wu, Heiner Boeing, Mark Lathrop, Göran Hallmans, Elizabeth A. Holly, Carol Giffen, Andrew A. Adjei, Consol Serra, Anne Tjønneland, Joseph F. Fraumeni, Alisa M. Goldstein, Ruth C. Travis, Rebecca Troisi, Dalsu Baris, Nalan Gokgoz, Olivier Cussenot, Xiang Deng, Yeul Hong Kim, Malin Sund, Sonja I. Berndt, E. David Crawford, Edward D. Yeboah, Sook Whan Sung, Françoise Clavel-Chapelon, Woon-Puay Koh, Nilgun Kurucu, Richard B. Hayes, Ashish M. Kamat, Beata Peplonska, Laurie Burdette, Ze Zhang Tang, Alan A. Arslan, Malcolm C. Pike, Sabina Sierri, J. Michael Gaziano, Lorna H. McNeil, Katherine A. McGlynn, Ulla Vogel, Logan G. Spector, H. Bas Bueno-de-Mesquita, Stephen J. Chanock, Jae Yong Park, Jennifer Prescott, Fernando Lecanda, Margaret A. Tucker, Ti Ding, Christian C. Abnet, Jenny Chang-Claude, Dimitrios Trichopoulos, Wei-Yen Lim, Wen Tan, Nick Orr, Jin Hee Kim, Stefano Porru, Chand Khanna, Robert R. McWilliams, Zhaoming Wang, Jeong Seon Ryu, David V. Conti, Alison P. Klein, Adonina Tardón, Robert J. Klein, Rebecca J. Rodabough, Mark H. Greene, Aruna Kamineni, Jie Lin, Rachael Z. Stolzenberg-Solomon, Patricia Hartge, Susan E. Hankinson, Young-Chul Kim, In Sam Kim, Luis Sierrasesúmaga, Roel Vermeulen, Paige M. Bracci, Mariana C. Stern, Louise A. Brinton, Myron D. Gross, Yong-Bing Xiang, Chih Yi Chen, G. A. Gerald Andriole, Paul S. Meltzer, Ying-Huang Tsai, Faith G. Davis, Ulrika Andersson, Paul Brennan, Sara Lindström, Chaoyu Wang, Giuseppe Mastrangelo, Laufey T. Amundadottir, Immaculata De Vivo, Bryan A. Bassig, Elisabete Weiderpass, Takashi Kohno, Nilanjan Chatterjee, Margaret R. Spitz, Pier Alberto Bertazzi, William Wheeler, David J. Hunter, Wei Tang, Qiuyin Cai, Naomi E. Allen, Molly Schwenn, Emily White, Min Shen, Adeline Seow, Laura E. Beane Freeman, James E. Mensah, Howard D. Sesso, Anna Luisa Di Stefano, Amanda Black, Manuela Gago-Dominguez, Christine B. Ambrosone, Avima M. Ruder, Martha S. Linet, Meir J. Stampfer, Robert C. Kurtz, Donald A. Barkauskas, Lisa W. Chu, Montserrat Garcia-Closas, Jason W. Hoskins, Melissa A. Austin, Kyoung Mu Lee, Jianxin Shi, Charles S. Fuchs, Nathaniel Rothman, Richard Gorlick, Piero Picci, Gianluca Severi, Ann G. Schwartz, Jian Gu, Christopher I. Amos, Marie-Christine Boutron-Ruault, Salvatore Panico, Alicja Wolk, Sara S. Strom, Lisa Mirabello, Jin-Hu Fan, Chin-Fu Hsiao, Neal D. Freedman, Geoffrey S. Tobias, Julie M. Gastier-Foster, Wang, Z, Zhu, B, Zhang, M, Parikh, H, Jia, J, Chung, Cc, Sampson, Jn, Hoskins, Jw, Hutchinson, A, Burdette, L, Ibrahim, A, Hautman, C, Raj, P, Abnet, Cc, Adjei, Aa, Ahlbom, A, Albanes, D, Allen, Ne, Ambrosone, Cb, Aldrich, M, Amiano, P, Amos, C, Andersson, U, Andriole G., Jr, Andrulis, Il, Arici, C, Arslan, Aa, Austin, Ma, Baris, D, Barkauskas, Da, Bassig, Ba, Beane Freeman, Le, Berg, Cd, Berndt, Si, Bertazzi, Pa, Biritwum, Rb, Black, A, Blot, W, Boeing, H, Boffetta, P, Bolton, K, Boutron Ruault, Mc, Bracci, Pm, Brennan, P, Brinton, La, Brotzman, M, Bueno de Mesquita, Hb, Buring, Je, Butler, Ma, Cai, Q, Cancel Tassin, G, Canzian, F, Cao, G, Caporaso, Ne, Carrato, A, Carreon, T, Carta, A, Chang, Gc, Chang, I, Chang Claude, J, Che, X, Chen, Cj, Chen, Cy, Chen, Ch, Chen, C, Chen, Ky, Chen, Ym, Chokkalingam, Ap, Chu, Lw, Clavel Chapelon, F, Colditz, Ga, Colt, J, Conti, D, Cook, Mb, Cortessis, Vk, Crawford, Ed, Cussenot, O, Davis, Fg, De Vivo, I, Deng, X, Ding, T, Dinney, Cp, Di Stefano, Al, Diver, Wr, Duell, Ej, Elena, Jw, Fan, Jh, Feigelson, H, Feychting, M, Figueroa, Jd, Flanagan, Am, Fraumeni JF, Jr, Freedman, Nd, Fridley, Bl, Fuchs, C, Gago Dominguez, M, Gallinger, S, Gao, Yt, Gapstur, Sm, Garcia Closas, M, Garcia Closas, R, Gastier Foster, Jm, Gaziano, Jm, Gerhard, D, Giffen, Ca, Giles, Gg, Gillanders, Em, Giovannucci, El, Goggins, M, Gokgoz, N, Goldstein, Am, Gonzalez, C, Gorlick, R, Greene, Mh, Gross, M, Grossman, Hb, Grubb R., 3rd, Gu, J, Guan, P, Haiman, Ca, Hallmans, G, Hankinson, Se, Harris, Cc, Hartge, P, Hattinger, C, Hayes, Rb, He, Q, Helman, L, Henderson, Be, Henriksson, R, Hoffman Bolton, J, Hohensee, C, Holly, Ea, Hong, Yc, Hoover, Rn, Hosgood HD, 3rd, Hsiao, Cf, Hsing, Aw, Hsiung, Ca, Hu, N, Hu, W, Hu, Z, Huang, M, Hunter, Dj, Inskip, Pd, Ito, H, Jacobs, Ej, Jacobs, Kb, Jenab, M, Ji, Bt, Johansen, C, Johansson, M, Johnson, A, Kaaks, R, Kamat, Am, Kamineni, A, Karagas, M, Khanna, C, Khaw, Kt, Kim, C, Kim, I, Kim, Yh, Kim, Yc, Kim, Yt, Kang, Ch, Jung, Yj, Kitahara, Cm, Klein, Ap, Klein, R, Kogevinas, M, Koh, Wp, Kohno, T, Kolonel, Ln, Kooperberg, C, Kratz, Cp, Krogh, V, Kunitoh, H, Kurtz, Rc, Kurucu, N, Lan, Q, Lathrop, M, Lau, Cc, Lecanda, F, Lee, Km, Lee, Mp, Le Marchand, L, Lerner, Sp, Li, D, Liao, Lm, Lim, Wy, Lin, D, Lin, J, Lindstrom, S, Linet, M, Lissowska, J, Liu, J, Ljungberg, B, Lloreta, J, Lu, D, Ma, J, Malats, N, Mannisto, S, Marina, N, Mastrangelo, G, Matsuo, K, Mcglynn, Ka, McKean Cowdin, R, Mcneill, Lh, Mcwilliams, Rr, Melin, B, Meltzer, P, Mensah, Je, Miao, X, Michaud, D, Mondul, Am, Moore, Le, Muir, K, Niwa, S, Olson, Sh, Orr, N, Panico, Salvatore, Park, Jy, Patel, Av, Patino Garcia, A, Pavanello, S, Peeters, Ph, Peplonska, B, Peters, U, Petersen, Gm, Picci, P, Pike, Mc, Porru, S, Prescott, J, Pu, X, Purdue, Mp, Qiao, Yl, Rajaraman, P, Riboli, E, Risch, Ha, Rodabough, Rj, Rothman, N, Ruder, Am, Ryu, J, Sanson, M, Schned, A, Schumacher, Fr, Schwartz, Ag, Schwartz, Kl, Schwenn, M, Scotlandi, K, Seow, A, Serra, C, Serra, M, Sesso, Hd, Severi, G, Shen, H, Shen, M, Shete, S, Shiraishi, K, Shu, Xo, Siddiq, A, Sierrasesumaga, L, Sierri, S, Loon Sihoe, Ad, Silverman, Dt, Simon, M, Southey, Mc, Spector, L, Spitz, M, Stampfer, M, Stattin, P, Stern, Mc, Stevens, Vl, Stolzenberg Solomon, Rz, Stram, Do, Strom, S, Su, Wc, Sund, M, Sung, Sw, Swerdlow, A, Tan, W, Tanaka, H, Tang, W, Tang, Zz, Tardon, A, Tay, E, Taylor, Pr, Tettey, Y, Thomas, Dm, Tirabosco, R, Tjonneland, A, Tobias, G, Toro, Jr, Travis, Rc, Trichopoulos, D, Troisi, R, Truelove, A, Tsai, Yh, Tucker, Ma, Tumino, R, Van Den Berg, D, Van Den Eeden, Sk, Vermeulen, R, Vineis, P, Visvanathan, K, Vogel, U, Wang, C, Wang, J, Wang, S, Weiderpass, E, Weinstein, Sj, Wentzensen, N, Wheeler, W, White, E, Wiencke, Jk, Wolk, A, Wolpin, Bm, Wong, Mp, Wrensch, M, Wu, C, Wu, T, Wu, X, Wu, Yl, Wunder, J, Xiang, Yb, Xu, J, Yang, Hp, Yang, Pc, Yatabe, Y, Ye, Y, Yeboah, Ed, Yin, Z, Ying, C, Yu, Cj, Yu, K, Yuan, Jm, Zanetti, Ka, Zeleniuch Jacquotte, A, Zheng, W, Zhou, B, Mirabello, L, Savage, Sa, Kraft, P, Chanock, Sj, Yeager, M, Landi, Mt, Shi, J, Chatterjee, N, Amundadottir, Lt, Wang, Z., Zhu, B., Zhang, M., Parikh, H., Jia, J., Chung, C.C., Sampson, J.N., Hoskins, J.W., Hutchinson, A., Burdette, L., Ibrahim, A., Hautman, C., Raj, P.S., Abnet, C.C., Adjei, A.A., Ahlbom, A., Albanes, D., Allen, N.E., Ambrosone, C.B., Aldrich, M., Amiano, P., Amos, C., Andersson, U., Gerald Andriole, G.A., Jr., Andrulis, I.L., Arici, C., Arslan, A.A., Austin, M.A., Baris, D., Barkauskas, D.A., Bassig, B.A., Freeman, L.E.B., Berg, C.D., Berndt, S.I., Bertazzi, P.A., Biritwum, R.B., Black, A., Blot, W., Boeing, H., Boffetta, P., Bolton, K., Boutron-Ruault, M.-C., Bracci, P.M., Brennan, P., Brinton, L.A., Brotzman, M., Bueno-de-Mesquita, H.B., Buring, J.E., Butler, M.A., Cai, Q., Cancel-Tassin, G., Canzian, F., Cao, G., Caporaso, N.E., Carrato, A., Carreon, T., Carta, A., Chang, G.-C., Chang, I.-S., Chang-Claude, J., Che, X., Chen, C.-J., Chen, C.-Y., Chen, C.-H., Chen, C., Chen, K.-Y., Chen, Y.-M., Chokkalingam, A.P., Chu, L.W., Clavel-Chapelon, F., Colditz, G.A., Colt, J.S., Conti, D., Cook, M.B., Cortessis, V.K., Crawford, E.D., Cussenot, O., Davis, F.G., De Vivo, I., Deng, X., Ding, T., Dinney, C.P., Di Stefano, A.L., Diver, W.R., Duell, E.J., Elena, J.W., Fan, J.-H., Feigelson, H.S., Feychting, M., Figueroa, J.D., Flanagan, A.M., Fraumeni, J.F., Jr., Freedman, N.D., Fridley, B.L., Fuchs, C.S., Gago-Dominguez, M., Gallinger, S., Gao, Y.-T., Gapstur, S.M., Garcia-Closas, M., Garcia-Closas, R., Gastier-Foster, J.M., Gaziano, J.M., Gerhard, D.S., Giffen, C.A., Giles, G.G., Gillanders, E.M., Giovannucci, E.L., Goggins, M., Gokgoz, N., Goldstein, A.M., Gonzalez, C., Gorlick, R., Greene, M.H., Gross, M., Grossman, H.B., Grubb, R., III and Gu, J., Guan, P., Haiman, C.A., Hallmans, G., Hankinson, S.E., Harris, C.C., Hartge, P., Hattinger, C., Hayes, R.B., He, Q., Helman, L., Henderson, B.E., Henriksson, R., Hoffman-Bolton, J., Hohensee, C., Holly, E.A., Hong, Y.-C., Hoover, R.N., Dean Hosgood, H., Hsiao, C.-F., Hsing, A.W., Hsiung, C.A., Hu, N., Hu, W., Hu, Z., Huang, M.-S., Hunter, D.J., Inskip, P.D., Ito, H., Jacobs, E.J., Jacobs, K.B., Jenab, M., Ji, B.-T., Johansen, C., Johansson, M., Johnson, A., Kaaks, R., Kamat, A.M., Kamineni, A., Karagas, M., Khanna, C., Khaw, K.-T., Kim, C., Kim, I.-S., Kim, J.H., Kim, Y.H., Kim, Y.-C., Kim, Y.T., Kang, C.H., Jung, Y.J., Kitahara, C.M., Klein, A.P., Klein, R., Kogevinas, M., Koh, W.-P., Kohno, T., Kolonel, L.N., Kooperberg, C., Kratz, C.P., Krogh, V., Kunitoh, H., Kurtz, R.C., Kurucu, N., Lan, Q., Lathrop, M., Lau, C.C., Lecanda, F., Lee, K.-M., Lee, M.P., Marchand, L.L., Lerner, S.P., Li, D., Liao, L.M., Lim, W.-Y., Lin, D., Lin, J., Lindstrom, S., Linet, M.S., Lissowska, J., Liu, J., Ljungberg, B., Lloreta, J., Lu, D., Ma, J., Malats, N., Mannisto, S., Marina, N., Mastrangelo, G., Matsuo, K., McGlynn, K.A., McKean-Cowdin, R., McNeil, L.H., McWilliams, R.R., Melin, B.S., Meltzer, P.S., Mensah, J.E., Miao, X., Michaud, D.S., Mondul, A.M., Moore, L.E., Muir, K., Niwa, S., Olson, S.H., Orr, N., Panico, S., Park, J.Y., Patel, A.V., Patino-Garcia, A., Pavanello, S., Peeters, P.H.M., Peplonska, B., Peters, U., Petersen, G.M., Picci, P., Pike, M.C., Porru, S., Prescott, J., Pu, X., Purdue, M.P., Qiao, Y.-L., Rajaraman, P., Riboli, E., Risch, H.A., Rodabough, R.J., Rothman, N., Ruder, A.M., Ryu, J.-S., Sanson, M., Schned, A., Schumacher, F.R., Schwartz, A.G., Schwartz, K.L., Schwenn, M., Scotlandi, K., Seow, A., Serra, C., Serra, M., Sesso, H.D., Severi, G., Shen, H., Shen, M., Shete, S., Shiraishi, K., Shu, X.-O., Siddiq, A., Sierrasesumaga, L., Sierri, S., Sihoe, A.D.L., Silverman, D.T., Simon, M., Southey, M.C., Spector, L., Spitz, M., Stampfer, M., Stattin, P., Stern, M.C., Stevens, V.L., Stolzenberg-Solomon, R.Z., Stram, D.O., Strom, S.S., Su, W.-C., Sund, M., Sung, S.W., Swerdlow, A., Tan, W., Tanaka, H., Tang, W., Tang, Z.-Z., Tardon, A., Tay, E., Taylor, P.R., Tettey, Y., Thomas, D.M., Tirabosco, R., Tjonneland, A., Tobias, G.S., Toro, J.R., Travis, R.C., Trichopoulos, D., Troisi, R., Truelove, A., Tsai, Y.-H., Tucker, M.A., Tumino, R., Van Den Berg, D., Van Den Eeden, S.K., Vermeulen, R., Vineis, P., Visvanathan, K., Vogel, U., Wang, C., Wang, J., Wang, S.S., Weiderpass, E., Weinstein, S.J., Wentzensen, N., Wheeler, W., White, E., Wiencke, J.K., Wolk, A., Wolpin, B.M., Wong, M.P., Wrensch, M., Wu, C., Wu, T., Wu, X., Wu, Y.-L., Wunder, J.S., Xiang, Y.-B., Xu, J., Yang, H.P., Yang, P.-C., Yatabe, Y., Ye, Y., Yeboah, E.D., Yin, Z., Ying, C., Yu, C.-J., Yu, K., Yuan, J.-M., Zanetti, K.A., Zeleniuch-Jacquotte, A., Zheng, W., Zhou, B., Mirabello, L., Savage, S.A., Kraft, P., Chanock, S.J., Yeager, M., Landi, M.T., Shi, J., Chatterjee, N., and Amundadottir, L.T.

Subjects
Male, SINGLE-NUCLEOTIDE POLYMORPHISM, Genome-wide association study, Epigenesis, Genetic, Gene Frequency, Molecular Biology, Genetics, Genetics (clinical), Neoplasms, Odds Ratio, Genome-wide association studies (GWAS), Telomerase, DNA METHYLATION Author Information, Association Studies Articles, General Medicine, PANCREATIC-CANCER, PROSTATE-CANCER, Neoplasm Proteins, POSTMENOPAUSAL BREAST-CANCER, TERT PROMOTER MUTATIONS, Gene Expression Regulation, Neoplastic, 2 SUSCEPTIBILITY LOCI, DNA methylation, Chromosomes, Human, Pair 5, Female, Risk, Locus (genetics), Single-nucleotide polymorphism, TERT and CLPTM1L gene, Biology, Polymorphism, Single Nucleotide, LUNG-CANCER, Humans, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, Allele, Gene, Allele frequency, Alleles, Genetic association, chromosome 5p15.33, Computational Biology, Membrane Proteins, DNA Methylation, Genetic Loci, TELOMERE LENGTH, Genome-Wide Association Study
Abstract

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 x 10(-39); Region 3: rs2853677, P = 3.30 x 10(-36) and PConditional = 2.36 x 10(-8); Region 4: rs2736098, P = 3.87 x 10(-12) and PConditional = 5.19 x 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 x 10(-6); and Region 6: rs10069690, P = 7.49 x 10(-15) and PConditional = 5.35 x 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 x 10(-18) and PConditional = 7.06 x 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.

Published
2014

230. Association of vegetable and fruit intake with gastric cancer risk among Japanese: a pooled analysis of four cohort studies

Author

T. Shimazu, K. Wakai, A. Tamakoshi, I. Tsuji, K. Tanaka, K. Matsuo, C. Nagata, T. Mizoue, M. Inoue, S. Tsugane, S. Sasazuki, Shizuka Sasazuki, Shoichiro Tsugane, Manami Inoue, Motoki Iwasaki, Tetsuya Otani, Norie Sawada, Taichi Shimazu, Taiki Yamaji, Ichiro Tsuji, Yoshitaka Tsubono, Yoshikazu Nishino, Akiko Tamakoshi, Keitaro Matsuo, Hidemi Ito, Kenji Wakai, Chisato Nagata, Tetsuya Mizoue, and Keitaro Tanaka

Subjects
Male, medicine.medical_specialty, Population, Diet Surveys, Cohort Studies, Asian People, Risk Factors, Stomach Neoplasms, Surveys and Questionnaires, Internal medicine, Vegetables, medicine, Humans, Food science, education, Prospective cohort study, Proportional Hazards Models, education.field_of_study, Proportional hazards model, business.industry, Incidence, Incidence (epidemiology), Confounding, Hazard ratio, Cancer, Hematology, medicine.disease, Diet, Oncology, Fruit, Female, business, Cohort study
Abstract

Background Prospective evidence is inconsistent regarding the association between vegetable/fruit intake and the risk of gastric cancer. Methods In an analysis of original data from four population-based prospective cohort studies encompassing 191 232 participants, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of gastric cancer incidence according to vegetable and fruit intake and conducted a meta-analysis of HRs derived from each study. Results During 2 094 428 person-years of follow-up, 2995 gastric cancer cases were identified. After adjustment for potential confounders, we found a marginally significant decrease in gastric cancer risk in relation to total vegetable intake but not total fruit intake: the multivariate-adjusted HR (95% CI; P for trend) for the highest versus the lowest quintile of total vegetable intake was 0.89 (0.77–1.03; P for trend = 0.13) among men and 0.83 (0.67–1.03; P for trend = 0.40) among women. For distal gastric cancer, the multivariate HR for the highest quintile of total vegetable intake was 0.78 (0.63–0.97; P for trend = 0.02) among men. Conclusion(s) This pooled analysis of data from large prospective studies in Japan suggests that vegetable intake reduces gastric cancer risk, especially the risk of distal gastric cancer among men.

Published
2014

231. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study

Author

Gordon, Fehringer, Darren R, Brenner, Zuo-Feng, Zhang, Yuan-Chin Amy, Lee, Keitaro, Matsuo, Hidemi, Ito, Qing, Lan, Paolo, Vineis, Mattias, Johansson, Kim, Overvad, Elio, Riboli, Antonia, Trichopoulou, Carlotta, Sacerdote, Isabelle, Stucker, Paolo, Boffetta, Paul, Brennan, David C, Christiani, Yun-Chul, Hong, Maria Teresa, Landi, Hal, Morgenstern, Ann G, Schwartz, Angela S, Wenzlaff, Gad, Rennert, John R, McLaughlin, Curtis C, Harris, Susan, Olivo-Marston, Irene, Orlow, Bernard J, Park, Marjorie, Zauderer, Juan M, Barros Dios, Alberto, Ruano Raviña, Jack, Siemiatycki, Anita, Koushik, Philip, Lazarus, Ana, Fernández-Somoano, Adonina, Tardon, Loic, Le Marchand, Hermann, Brenner, Kai-Uwe, Saum, Eric J, Duell, Angeline S, Andrew, Neonila, Szeszenia-Dabrowska, Jolanta, Lissowska, David, Zaridze, Peter, Rudnai, Eleonora, Fabianova, Dana, Mates, Lenka, Foretova, Vladimir, Janout, Vladimir, Bencko, Ivana, Holcatova, Angela Cecilia, Pesatori, Dario, Consonni, Ann, Olsson, Kurt, Straif, and Rayjean J, Hung

Subjects
Male, Asia, Lung Neoplasms, Alcohol Drinking, education, Oncology and Carcinogenesis, Cardiovascular, Article, DIET, Cohort Studies, Alcohol Use and Health, Substance Misuse, liquor, ENVIRONMENTAL TOBACCO-SMOKE, Risk Factors, Tobacco, Humans, EXPOSURE, Oncology & Carcinogenesis, wine, Lung, METAANALYSIS, Cancer, Aged, Science & Technology, Tobacco Smoke and Health, alcohol, Prevention, Alcoholic Beverages, Smoking, food and beverages, CONSUMPTION, Middle Aged, ETIOLOGY, Stroke, Europe, Alcoholism, lung cancer, Good Health and Well Being, Oncology, Case-Control Studies, North America, Respiratory, beer, LIFE-STYLE, Female, Life Sciences & Biomedicine, BEVERAGE PREFERENCE, 1112 Oncology And Carcinogenesis
Abstract

It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0-4.9 g per day: OR = 0.80, 95% CI = 0.70-0.90; 5-9.9 g per day: OR = 0.82, 95% CI = 0.69-0.99; 10-19.9 g per day: OR = 0.79, 95% CI = 0.65-0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance.

Published
2016

232. Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry

Author

Hidemi Ito, Ji Yeob Choi, Douglas F. Easton, Keitaro Matsuo, Paul D.P. Pharoah, Joe Dennis, Daehee Kang, Xingyi Guo, Yong-Bing Xiang, Ying Zheng, Montserrat Garcia-Closas, Chen-Yang Shen, Paul Brennan, Chiu-Chen Tseng, Manjeet K. Bolla, Wanqing Wen, Qiuyin Cai, Soo Hwang Teo, Jacques Simard, Kyriaki Michailidou, Wei Zheng, Xiao-Ou Shu, Per Hall, Yu-Tang Gao, Hui Miao, Qin Wang, Anna H. Wu, Jirong Long, Cheng Har Yip, Artitaya Lophatananon, Suleeporn Sangrajrang, Alison M. Dunning, Kenneth Muir, Shou-Tung Chen, Mikael Hartman, Dennis, Joe [0000-0003-4591-1214], Wang, Jean [0000-0002-9139-0627], Dunning, Alison [0000-0001-6651-7166], Pharoah, Paul [0000-0001-8494-732X], Easton, Douglas [0000-0003-2444-3247], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Oncology, Genome-wide association study, Bioinformatics, 0302 clinical medicine, Risk Factors, Surgical oncology, Odds Ratio, skin and connective tissue diseases, Medicine(all), Research Support, Non-U.S. Gov't, Methodology for SNP data analysis, 3. Good health, Population Surveillance, 030220 oncology & carcinogenesis, Female, Risk assessment, Algorithms, Research Article, Asian Continental Ancestry Group, medicine.medical_specialty, Asia, Breast Neoplasms, Single-nucleotide polymorphism, Risk Assessment, 03 medical and health sciences, Breast cancer, Asian People, Research Support, N.I.H., Extramural, Prediction model, Internal medicine, Journal Article, medicine, Humans, Genetic Predisposition to Disease, Statistical methods in genetics, Genetic Association Studies, Genetic association, Models, Statistical, business.industry, Case-control study, Genetic Variation, Odds ratio, medicine.disease, 030104 developmental biology, Case-Control Studies, business, Breast cancer risk, Research Support, U.S. Gov't, Non-P.H.S, Genome-Wide Association Study
Abstract

Background Approximately 100 common breast cancer susceptibility alleles have been identified in genome-wide association studies (GWAS). The utility of these variants in breast cancer risk prediction models has not been evaluated adequately in women of Asian ancestry. Methods We evaluated 88 breast cancer risk variants that were identified previously by GWAS in 11,760 cases and 11,612 controls of Asian ancestry. SNPs confirmed to be associated with breast cancer risk in Asian women were used to construct a polygenic risk score (PRS). The relative and absolute risks of breast cancer by the PRS percentiles were estimated based on the PRS distribution, and were used to stratify women into different levels of breast cancer risk. Results We confirmed significant associations with breast cancer risk for SNPs in 44 of the 78 previously reported loci at P

Published
2016

233. Abstract LB-174: Genome-wide association meta-analysis identifies novel GP2 gene risk variants for pancreatic cancer in the Japanese population

Author

Masayuki Yamamoto, Atsushi Shimizu, Hidemi Ito, Hiromi Sakamoto, Yasushi Adachi, Yingsong Lin, Kenji Wakai, Yoichiro Kamatani, Michiaki Kubo, Takashi Kadowaki, Naoki Sasahira, Haruhisa Nakao, Mitsuru Mori, Keitaro Matsuo, Makoto Ueno, Shogo Kikuchi, Naoto Egawa, Fumihiko Matsuda, Hiroshi Ishii, Shoichiro Tsugane, Masahiro Nakatochi, and Teruhiko Yoshida

Subjects
Genetics, Cancer Research, Cancer, Genome-wide association study, Single-nucleotide polymorphism, Biology, medicine.disease, Oncology, Pancreatic cancer, Meta-analysis, Mendelian randomization, medicine, SNP, Genetic association
Abstract

Pancreatic cancer is one of the most challenging malignancies because of its dismal prognosis, largely unknown etiology, and absence of early detection method. Here we report the results of a meta-analysis of three genome-wide association studies (GWAS) involving 2039 pancreatic cancer cases and 32592 control subjects, which represent the largest sample size in the Japanese population. To complement the SNP-based GWAS, we performed a gene-based GWAS using MAGMA. Given the pleiotropic effects observed for the top variants, we performed a Mendelian randomization (MR) analysis to address the possible causal relationship between type-2 diabetes (T2D) and pancreatic cancer risk, using 82 T2D-related SNPs and 25 hemoglobin A1c (HbA1c)-related SNPs as instrumental variables. We identified 3 (13q12.2, 13q22.1, and 16p12.3) genome-wide significant loci (P Citation Format: Yingsong Lin, Masahiro Nakatochi, Hidemi Ito, Yoichiro Kamatani, Hiromi Sakamoto, Hiroshi Ishii, Naoki Sasahira, Makoto Ueno, Naoto Egawa, Mitsuru Mori, Haruhisa Nakao, Yasushi Adachi, Kenji Wakai, Shoichiro Tsugane, Masayuki Yamamoto, Atsushi Shimizu, Takashi Kadowaki, Teruhiko Yoshida, Fumihiko Matsuda, Michiaki Kubo, Shogo Kikuchi, Keitaro Matsuo. Genome-wide association meta-analysis identifies novel GP2 gene risk variants for pancreatic cancer in the Japanese population [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-174.

Published
2019

234. Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia

Author

Woon-Puay Koh, Keiko Wada, Keun-Young Yoo, Yoon Ok Ahn, Manami Inoue, Shoichiro Tsugane, Jian-Min Yuan, Jing Gao, Xiao-Ou Shu, John D. Potter, Eiko Saito, Yumi Sugawara, Norie Sawada, Jae Jeong Yang, Seiki Kanemura, Chen-Yang Shen, Eric J. Grant, Mangesh S. Pednekar, Chisato Nagata, Fujiko Irie, Wanqing Wen, Keitaro Matsuo, Shafiur Rahman, Wen-Harn Pan, Hidemi Ito, Hui Cai, Pei Ei Wu, Hong Lan Li, San Lin You, Yu Chen, Sue K. Park, Jiang He, Shu Zhang, Toshimi Sairenchi, Prakash C. Gupta, Kee Seng Chia, Habibul Ashan, Yasutake Tomata, Jin-Hu Fan, Chien-Jen Chen, Paolo Boffetta, Myung Hee Shin, Akiko Tamakoshi, Yu-Tang Gao, Wei Zheng, Danxia Yu, Yong-Bing Xiang, Daehee Kang, Ichiro Tsuji, Renwei Wang, Atsuko Sadakane, Dongfeng Gu, You-Lin Qiao, Yang J.J., Yu D., Wen W., Saito E., Rahman S., Shu X.-O., Chen Y., Gupta P.C., Gu D., Tsugane S., Xiang Y.-B., Gao Y.-T., Yuan J.-M., Tamakoshi A., Irie F., Sadakane A., Tomata Y., Kanemura S., Tsuji I., Matsuo K., Nagata C., Chen C.-J., Koh W.-P., Shin M.-H., Park S.K., Wu P.-E., Qiao Y.-L., Pednekar M.S., He J., Sawada N., Li H.-L., Gao J., Cai H., Wang R., Sairenchi T., Grant E., Sugawara Y., Zhang S., Ito H., Wada K., Shen C.-Y., Pan W.-H., Ahn Y.-O., You S.-L., Fan J.-H., Yoo K.-Y., Ashan H., Chia K.S., Boffetta P., Inoue M., Kang D., Potter J.D., and Zheng W.

Subjects
Adult, Male, Asia, Risk Factors, Diabetes management, Cause of Death, Diabetes mellitus, Diabetes Mellitus, Prevalence, medicine, Humans, Prospective Studies, Prospective cohort study, Proportional Hazards Models, Aged, business.industry, Proportional hazards model, Hazard ratio, Diabetes Mellitu, General Medicine, Middle Aged, medicine.disease, Prospective Studie, Relative risk, Cohort, Proportional Hazards Model, Female, business, Body mass index, Human, Demography
Abstract

Importance: Asia is home to the largest diabetic populations in the world. However, limited studies have quantified the association of diabetes with all-cause and cause-specific mortality in Asian populations. Objectives: To evaluate the association of diabetes with all-cause and cause-specific mortality in Asia and to investigate potential effect modifications of the diabetes-mortality associations by participants' age, sex, education level, body mass index, and smoking status. Design, Setting, and Participants: This pooled analysis incorporated individual participant data from 22 prospective cohort studies of the Asia Cohort Consortium conducted between 1963 and 2006. A total of 1 002 551 Asian individuals (from mainland China, Japan, South Korea, Singapore, Taiwan, India, and Bangladesh) were followed up for more than 3 years. Cohort-specific hazard ratios and 95% confidence intervals for all-cause and cause-specific mortality were estimated using Cox regression models and then pooled using random-effects meta-analysis. Analysis was conducted between January 10, 2018, and August 31, 2018. Exposures: Doctor-diagnosed diabetes, age, sex, education level, body mass index, and smoking status. Main Outcomes and Measures: All-cause and cause-specific mortality. Results: Of 1 002 551 participants (518 537 [51.7%] female; median [range] age, 54.0 [30.0-98.0] years), 148 868 deaths were ascertained during a median (range) follow-up of 12.6 (3.0-38.9) years. The overall prevalence of diabetes reported at baseline was 4.8% for men and 3.6% for women. Patients with diabetes had a 1.89-fold risk of all-cause death compared with patients without diabetes (hazard ratio [HR], 1.89; 95% CI, 1.74-2.04), with the highest relative risk of death due to diabetes itself (HR, 22.8; 95% CI, 18.5-28.1), followed by renal disease (HR, 3.08; 95% CI, 2.50-3.78), coronary heart disease (HR, 2.57; 95% CI, 2.19-3.02), and ischemic stroke (HR, 2.15; 95% CI, 1.85-2.51). The adverse diabetes-mortality associations were more evident among women (HR, 2.09; 95% CI, 1.89-2.32) than among men (HR, 1.74; 95% CI, 1.62-1.88) (P for interaction

Published
2019

235. Tobacco Smoking and Mortality in Asia

Author

Ichiro Tsuji, Hidemi Ito, Hong Lan Li, San Lin You, Kee Seng Chia, Fujiko Irie, Shoichiro Tsugane, Keiko Wada, Jian-Min Yuan, Eiko Saito, Woon-Puay Koh, Manami Inoue, Keun-Young Yoo, Myung Hee Shin, Jing Gao, Mangesh S. Pednekar, Chisato Nagata, Chen-Yang Shen, John D. Potter, Yoon Ok Ahn, You-Lin Qiao, Paolo Boffetta, Dongfeng Gu, Habibul Ashan, Daehee Kang, Renwei Wang, Chien-Jen Chen, Norie Sawada, Keitaro Matsuo, Atsuko Sadakane, Wen-Harn Pan, Wanqing Wen, Danxia Yu, Yong-Bing Xiang, Hui Cai, Sue K. Park, Xiao-Ou Shu, Akiko Tamakoshi, Yu-Tang Gao, Jiang He, Shafiur Rahman, Yumi Sugawara, Wei Zheng, Yasutake Tomata, Eric J. Grant, Jae Jeong Yang, Seiki Kanemura, Prakash C. Gupta, Yang J.J., Yu D., Wen W., Shu X.-O., Saito E., Rahman S., Gupta P.C., He J., Tsugane S., Xiang Y.-B., Gao Y.-T., Koh W.-P., Tamakoshi A., Irie F., Sadakane A., Tsuji I., Kanemura S., Matsuo K., Nagata C., Chen C.-J., Yuan J.-M., Shin M.-H., Park S.K., Pan W.-H., Qiao Y.-L., Pednekar M.S., Gu D., Sawada N., Li H.-L., Gao J., Cai H., Grant E., Tomata Y., Sugawara Y., Ito H., Wada K., Shen C.-Y., Wang R., Ahn Y.-O., You S.-L., Yoo K.-Y., Ashan H., Chia K.S., Boffetta P., Inoue M., Kang D., Potter J.D., and Zheng W.

Subjects
Asia, business.industry, Hazard ratio, Tobacco control, General Medicine, medicine.disease, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Relative risk, Cohort, Attributable risk, Tobacco Smoking, medicine, Humans, 030212 general & internal medicine, Cohort Studie, Prospective cohort study, Lung cancer, business, Human, Demography, Cohort study
Abstract

Importance Understanding birth cohort–specific tobacco smoking patterns and their association with total and cause-specific mortality is important for projecting future deaths due to tobacco smoking across Asian populations. Objectives To assess secular trends of tobacco smoking by countries or regions and birth cohorts and evaluate the consequent mortality in Asian populations. Design, Setting, and Participants This pooled meta-analysis was based on individual participant data from 20 prospective cohort studies participating in the Asia Cohort Consortium. Between September 1, 2017, and March 31, 2018, a total of 1 002 258 Asian individuals 35 years or older were analyzed using Cox proportional hazards regression analysis and random-effects meta-analysis. The pooled results were presented for mainland China; Japan; Korea, Singapore, and Taiwan; and India. Exposures Tobacco use status, age at starting smoking, number of cigarettes smoked per day, and age at quitting smoking. Main Outcomes and Measures Country or region and birth cohort–specific mortality and the population attributable risk for deaths from all causes and from lung cancer. Results Of 1 002 258 participants (51.1% women and 48.9% men; mean [SD] age at baseline, 54.6 [10.4] years), 144 366 deaths (9158 deaths from lung cancer) were ascertained during a mean (SD) follow-up of 11.7 (5.3) years. Smoking prevalence for men steadily increased in China and India, whereas it plateaued in Japan and Korea, Singapore, and Taiwan. Among Asian male smokers, the mean age at starting smoking decreased in successive birth cohorts, while the mean number of cigarettes smoked per day increased. These changes were associated with an increasing relative risk of death in association with current smoking in successive birth cohorts of pre-1920, 1920s, and 1930 or later, with hazard ratios for all-cause mortality of 1.26 (95% CI, 1.17-1.37) for the pre-1920 birth cohort, 1.47 (95% CI, 1.35-1.61) for the 1920s birth cohort, and 1.70 (95% CI, 1.57-1.84) for the cohort born in 1930 or later. The hazard ratios for lung cancer mortality were 3.38 (95% CI, 2.25-5.07) for the pre-1920 birth cohort, 4.74 (95% CI, 3.56-6.32) for the 1920s birth cohort, and 4.80 (95% CI, 3.71-6.19) for the cohort born in 1930 or later. Tobacco smoking accounted for 12.5% (95% CI, 8.4%-16.3%) of all-cause mortality in the pre-1920 birth cohort, 21.1% (95% CI, 17.3%-24.9%) of all-cause mortality in the 1920s birth cohort, and 29.3% (95% CI, 26.0%-32.3%) of all-cause mortality for the cohort born in 1930 or later. Tobacco smoking among men accounted for 56.6% (95% CI, 44.7%-66.3%) of lung cancer mortality in the pre-1920 birth cohort, 66.6% (95% CI, 58.3%-73.5%) of lung cancer mortality in the 1920s birth cohort, and 68.4% (95% CI, 61.3%-74.4%) of lung cancer mortality for the cohort born in 1930 or later. For women, tobacco smoking patterns and lung cancer mortality varied substantially by countries and regions. Conclusions and Relevance In this study, mortality associated with tobacco smoking continued to increase among Asian men in recent birth cohorts, indicating that tobacco smoking will remain a major public health problem in most Asian countries in the coming decades. Implementing comprehensive tobacco-control programs is warranted to end the tobacco epidemic.

Published
2019

236. Coffee and green tea consumption is associated with upper aerodigestive tract cancer in Japan

Author

Isao Oze, Hidemi Ito, Satoyo Hosono, Masayuki Shinoda, Shunzo Hatooka, Hideo Tanaka, Miki Watanabe, Kazuo Tajima, Yasuhisa Hasegawa, Keitaro Matsuo, and Daisuke Kawakita

Subjects
Cancer Research, business.industry, Head and neck cancer, Confounding, Case-control study, Odds ratio, Esophageal cancer, medicine.disease, Green tea, Confidence interval, Upper aerodigestive tract, Oncology, Environmental health, medicine, Food science, business
Abstract

The impact of coffee and green tea consumption on upper aerodigestive tract (UADT) cancer risk has not been established. Evaluation of the possible anticarcinogenic properties of their ingredients is confounded by the potential increase in risk owing to the high temperatures at which these beverages are generally consumed. We conducted a case–control study to evaluate the association between coffee and tea consumption and the risk of UADT cancer. The study enrolled 961 patients with UADT cancer and 2,883 noncancer outpatients who visited Aichi Cancer Center between 2001 and 2005. Information on coffee and green tea consumption and other lifestyle factors was collected via a self-administered questionnaire. Consumption of three or more cups of coffee per day had a significant inverse association with UADT cancer [odds ratio (OR) 0.73, 95% confidence interval (CI) 0.55–0.96]. In contrast, consumption of three or more cups of green tea per day had a significant positive association with UADT cancer (OR 1.39, 95% CI 1.13–1.70). These associations were evident for head and neck cancer but not for esophageal cancer. The association of coffee consumption with head and neck cancer was observed only among never smokers and alcohol drinkers. Similarly, the association of green tea consumption was observed among never smokers and never alcohol drinkers. No change in these associations was seen on stratification by each confounding factors. These findings suggest that consumption of coffee might be associated with a decreased risk of UADT cancer, whereas that of green tea might be associated with an increased risk.

Published
2013

237. Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1

Author

Per Hall, Hui Cai, Roger L. Milne, Douglas F. Easton, Anja Rudolph, José Ignacio Arias, Vessela N. Kristensen, Julia A. Knight, Lisa B. Signorello, Petra Seibold, Jonathan Tyrer, Arto Mannermaa, Alan Ashworth, Andreas Schneeweiss, Sandra Deming-Halverson, Katarzyna Durda, Kimael Eriksson, Thilo Dörk, Isabel dos Santos Silva, Alfons Meindl, Laura Baglietto, Fredrick R. Schumacher, Peter Devilee, Qiuyin Cai, Janet E. Olson, Keith Humphreys, Annegien Broeks, Soo Hwang Teo, Michael P. Lux, Sze Yee Phuah, Federick Marme, Pascal Guénel, Hidemi Ito, Irene L. Andrulis, Natalia Bogdanova, Christoph Engel, Juliet D. French, Nina Ditsch, Xianshu Wang, Susan L. Slager, Bernardo Bonanni, Hermann Brenner, Nick Orr, Marie Rose Christiaens, Martine Dumont, Martin O'Reilly, Annika Lindblom, Catriona McLean, Ans M.W. van den Ouweland, Marjanka K. Schmidt, Sara Margolin, Kerstin B. Meyer, Martha J. Shrubsole, Malcolm W.R. Reed, Hans Ulrich Ulmer, Georgia Chenevix-Trench, Kyriaki Michailidou, Brian E. Henderson, Nicola Miller, Sandrine Tchatchou, Stig E. Bojesen, Pornthep Siriwanarangsan, Joe Dennis, Jaana M. Hartikainen, Matthias W. Beckmann, Fergus J. Couch, David Van Den Berg, Celine M. Vachon, Pierre Laurent-Puig, Montserrat Garcia-Closas, Ian Tomlinson, Thomas Brüning, Maya Ghoussaini, Mikael Hartman, Kristiina Aittomäki, Thérèse Truong, Katarzyna Jaworska, Yon Ko, Yu Tang Gao, Paolo Peterlongo, Stacey L. Edwards, Saskia Carlebur, Hartef Darabi, Pei Ei Wu, Ute Hamann, M. Pilar Zamora, Taru A. Muranen, Jirong Long, Stephen J. Chanock, William Blot, Sonja Helbig, Heiko Müller, Christina Clarke Dur, Ji Yeob Choi, Melissa C. Southey, Olivia Fletcher, Ming-Feng Hou, Hiroji Iwata, Nichola Johnson, Wei Zheng, Robert Winqvist, Diether Lambrechts, Javier Benitez, Chen-Yang Shen, Suleeporn Sangrajrang, Chia-Ni Hsiung, James McKay, Kristen S. Purrington, Cheng Har Yip, Ann Smeets, Valerie Gaborieau, Keitaro Matsuo, Anthony J. Swerdlow, Anne Lise Børresen-Dale, Anna Jakubowska, Dong Young Noh, Paul D.P. Pharoah, Ines de Santiago, Hiltrud Brauch, Vesa Kataja, Yasushi Yatabe, Anna H. Wu, Grethe I. Grenaker Alnæs, Jonine D. Figueroa, Christopher A. Haiman, Florence Menegaux, Hoda Anton-Culver, Paul Brennan, Veli-Matti Kosma, Bruce A.J. Ponder, Dieter Flesch-Janys, Thomas Rüdiger, Shaik Ahmad Buhari, Katri Pylkäs, Gord Glendon, Rita K. Schmutzler, Julian Peto, Chiu-Chen Tseng, Sune F. Nielsen, Mark S. Goldberg, Angela Cox, Carolien H.M. van Deurzen, Artitaya Lophatananon, Radhika Prathalingham, Børge G. Nordestgaard, Arja Jukkola-Vuorinen, Wei Lu, Peter A. Fasching, Florentia Fostira, Wei-Yen Lim, Barbara Burwinkel, Jenny Chang-Claude, Michael J. Kerin, Maartje J. Hooning, Kamila Czene, Asta Försti, Loic Le Marchand, Gianluca Severi, Volker Arndt, John L. Hopper, Jan Lubinski, Jacques Simard, Frans B. L. Hogervorst, Alison M. Dunning, Kenneth Muir, Saila Kauppila, Laura J. van't Veer, John W.M. Martens, Helen Tsimiklis, Loris Bernard, Heli Nevanlinna, Jolanta Lissowska, Robert Pilarski, Qin Wang, Paolo Radice, Robert A.E.M. Tollenaar, Jianjun Liu, Graham G. Giles, Henrik Flyger, Arif B. Ekici, Xiao-Ou Shu, Manjeet K. Bolla, Carl Blomqvist, Daehee Kang, Argyrios Ziogas, Bernard Thienpont, Patricia Harrington, Sue K. Park, Christa Stegmaier, Sarah Stewart-Brown, Elinor J. Sawyer, Miao Hui, Susan L. Neuhausen, Daniel O. Stram, Christof Sohn, Minouk J. Schoemaker, Jingmei Li, Carmel Apicella, Caroline M. Seynaeve, Clinical Genetics, Medical Oncology, Pathology, and Cardiothoracic Surgery

Subjects
Fibroblast Growth Factor, african-american, Genome-wide association study, Medical and Health Sciences, Chromosome conformation capture, 0302 clinical medicine, 2.1 Biological and endogenous factors, Genetics(clinical), Aetiology, Promoter Regions, Genetic, Genetics (clinical), Cancer, African Continental Ancestry Group, Genetics & Heredity, Genetics, 0303 health sciences, Tumor, Chromosome Mapping, Biological Sciences, 3. Good health, Chromatin, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, kConFab Investigators, Female, RNA Interference, women, GENICA Network, transcription, reveals, Type 2, Alleles, Asian Continental Ancestry Group, Binding Sites, Breast Neoplasms, Case-Control Studies, Cell Line, Tumor, Chromatin Immunoprecipitation, E2F1 Transcription Factor, European Continental Ancestry Group, Genetic Association Studies, Haplotypes, Hepatocyte Nuclear Factor 3-alpha, Humans, Position-Specific Scoring Matrices, Protein Binding, Receptor, Fibroblast Growth Factor, Type 2, Genetic Loci, Receptor, Australian Ovarian Cancer Study Group, Black People, Single-nucleotide polymorphism, Locus (genetics), Biology, determinant, White People, Article, Cell Line, estrogen-receptor binding, Promoter Regions, 03 medical and health sciences, Genetic, SDG 3 - Good Health and Well-being, Asian People, Breast Cancer, expression, ddc:610, Allele, 030304 developmental biology, Neoplastic, Prevention, Human Genome, Molecular biology, susceptibility loci, Gene Expression Regulation, genome-wide association, chromatin, Hypersensitive site, Chromatin immunoprecipitation
Abstract

The 10q26 locus in the second intron of FGFR2 is the locus most strongly associated with estrogen-receptor-positive breast cancer in genome-wide association studies. We conducted fine-scale mapping in case-control studies genotyped with a custom chip (iCOGS), comprising 41 studies (n = 89,050) of European ancestry, 9 Asian ancestry studies (n = 13,983), and 2 African ancestry studies (n = 2,028) from the Breast Cancer Association Consortium. We identified three statistically independent risk signals within the locus. Within risk signals 1 and 3, genetic analysis identified five and two variants, respectively, highly correlated with the most strongly associated SNPs. By using a combination of genetic fine mapping, data on DNase hypersensitivity, and electrophoretic mobility shift assays to study protein-DNA binding, we identified rs35054928, rs2981578, and rs45631563 as putative functional SNPs. Chromatin immunoprecipitation showed that FOXA1 preferentially bound to the risk-associated allele (C) of rs2981578 and was able to recruit ERα to this site in an allele-specific manner, whereas E2F1 preferentially bound the risk variant of rs35054928. The risk alleles were preferentially found in open chromatin and bound by Ser5 phosphorylated RNA polymerase II, suggesting that the risk alleles are associated with changes in transcription. Chromatin conformation capture demonstrated that the risk region was able to interact with the promoter of FGFR2, the likely target gene of this risk region. A role for FOXA1 in mediating breast cancer susceptibility at this locus is consistent with the finding that the FGFR2 risk locus primarily predisposes to estrogen-receptor-positive disease. © 2013 The American Society of Human Genetics.

Published
2013
Full Text
View/download PDF

239. Differences in incidence and trends of haematological malignancies in <scp>J</scp> apan and the <scp>U</scp> nited <scp>S</scp> tates

Author

Tomohiro Matsuda, Hidemi Ito, Akiko Shibata, Dai Chihara, Keitaro Matsuo, Akira Katsumi, Dennis D. Weisenburger, Shigeo Nakamura, Lindsay M. Morton, and Sobue Tomotaka

Subjects
Male, Oncology, medicine.medical_specialty, Population, Disease, Japan, hemic and lymphatic diseases, Internal medicine, medicine, Surveillance, Epidemiology, and End Results, Humans, Registries, education, education.field_of_study, Mycosis fungoides, business.industry, Incidence, Lymphoma, Non-Hodgkin, Incidence (epidemiology), Hematology, medicine.disease, Hodgkin Disease, United States, Confidence interval, Lymphoma, Hematologic Neoplasms, Immunology, Etiology, Female, business
Abstract

The incidence of a malignant disease reflects the genetic and cumulative exposure to the environment of a population. Therefore, evaluation of the incidence and trends of a disease in different populations may provide insights into its aetiology and pathogenesis. To evaluate the incidence of haematological malignancies according to specific subtypes, we used population-based registry data in Japan (N = 125 148) and the United States (US; N = 172 925) from 1993 to 2008. The age-adjusted incidence of haematological malignancies in Japan was approximately one-half that in the US but has been increasing significantly, whereas no significant change was seen in the US [annual percent change (95% C confidence interval): Japan, +2·4% (1·7, 3·1); US, +0·1% (-0·1, 0·2)]. Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) showed the largest differences in incidence, with the most remarkable differences observed for chronic lymphocytic leukaemia, HL-nodular sclerosis, mycosis fungoides and cutaneous T-cell lymphoma. HL and NHL are increasing substantially in Japan but not in the US, suggesting that environmental exposures, such as Westernization of the life style may be causing this increase. Differences in the incidence and trends for specific subtypes also showed a marked contrast across subtypes, which, in turn, may provide significant new insights into disease aetiology in the future.

Published
2013

240. Factors Associated With Weight Gain After Smoking Cessation Therapy in Japan

Author

Hidemi Ito, Chie Taniguchi, Akihiro Tokoro, Hiroshi Suehisa, Kazunobu Tachibana, Hideo Tanaka, Isao Oze, Yasuhiro Nozaki, Nobuyo Nakamichi, Hisataka Sakakibara, Hideo Saka, and Yukio Suzuki

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Weight Gain, Cohort Studies, chemistry.chemical_compound, Asian People, Japan, Risk Factors, Quinoxalines, Internal medicine, medicine, Nursing Interventions Classification, Humans, Nicotinic Agonists, Varenicline, General Nursing, Aged, Motivation, business.industry, Weight change, Age Factors, Tobacco Use Disorder, Benzazepines, Middle Aged, Stepwise regression, medicine.disease, Comorbidity, Logistic Models, chemistry, Physical therapy, Smoking cessation, Female, Smoking Cessation, Self Report, medicine.symptom, business, Weight gain, Cohort study
Abstract

Background: Smoking cessation is often followed by weight gain, which may attenuate motivation to sustain a quit attempt. Objectives: The aim was to identify factors associated with weight gain in smokers who received smoking cessation therapy (SCT) in Japan. Methods: The weight change in 283 smokers between baseline and 12 months after finishing SCT was observed. Factors associated with marked weight gain of 3.5 kg or more were identified using stepwise logistic regression. Results: Smoking cessation success was 83% (234/283) at the completion of SCT but decreased to 69% (194/283) 12 months later. Twelve months after the end of SCT, age 50 and over (OR = 0.38, 95% CI [0.19, 0.76]) and varenicline use (OR = 0.30, 95% CI [0.11, 0.78]) were protected against marked weight gain, whereas presence of a comorbidity (OR = 3.33, 95% CI [1.10, 10.00]), high level of nicotine dependence at baseline (OR = 2.07, 95% CI [1.09, 3.92]), and successfully quitting smoking (OR = 4.57, 95% CI [1.94, 10.08]) were associated with marked weight gain. Discussion: Understanding the factors associated with weight gain after smoking cessation can help in the design of nursing interventions to lessen or prevent weight gain among smokers who try to quit.

Published
2013

241. Polymorphisms in Base Excision Repair Genes Are Associated With Endometrial Cancer Risk Among Postmenopausal Japanese Women

Author

Kaoru Hirose, Toru Nakanishi, Hidemi Ito, Kazuo Tajima, Keitaro Matsuo, Hideo Tanaka, Isao Oze, Miki Watanabe, and Satoyo Hosono

Subjects
Adult, Oncology, medicine.medical_specialty, DNA Repair, Genotype, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, XRCC1, Asian People, Risk Factors, MUTYH, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Genetic Association Studies, Aged, business.industry, Endometrial cancer, Haplotype, Obstetrics and Gynecology, Cancer, Middle Aged, medicine.disease, APEX1, Endometrial Neoplasms, Postmenopause, Case-Control Studies, Female, business, Carcinoma, Endometrioid, Body mass index
Abstract

ObjectivesPolymorphisms in base excision repair (BER) genes are associated with risk for several types of cancers but have not been studied with respect to endometrial cancer among Japanese women. Therefore, we conducted a case-control study to explore the association between polymorphisms in BER genes and the risk for endometrial cancer.Methods/MaterialsThis study included a total of 91 postmenopausal subjects with endometrial cancer and 261 controls without cancer who visited the Aichi Cancer Center between 2001 and 2005. We focused on single nucleotide polymorphisms within coding regions of 5 BER genes (OGG1,MUTYH,XRCC1,APEX1, andPARP1). To assess lifestyle in the etiology of endometrial cancer, we used a self-administered questionnaire. Associations were evaluated using multivariate unconditional logistic regression models. We also assessed whether there were intergenic associations or an interaction with obesity.ResultsWe observed a significant association between endometrial cancer risk andXRCC1rs1799782 (C > T, Arg194Trp) andXRCC1rs25487 (G > A, Arg399Gln). We uncovered a significant association between obesity (body mass index, ≥25) and rs25487. TheXRCC1polymorphisms were in complete linkage disequilibrium, and theXRCC1haplotype TG associated significantly with endometrial cancer risk. The interaction between the CA haplotype and body mass index was marginally significant, whereas interaction between haplotype inXRCC1and rs1136410 (PARP1) was not significant.ConclusionsWe found a significant association between endometrial cancer risk andXRCC1polymorphisms and haplotype TG in postmenopausal Japanese women.

Published
2013

242. The energy spectrum of ultra-high-energy cosmic rays measured by the Telescope Array FADC fluorescence detectors in monocular mode

Author

T. Kanbe, Y. Kobayashi, Fumiya Shibata, S. Kitamura, Robert M. Anderson, R. Ishimori, Hidemi Ito, Sergey Troitsky, Grigory Rubtsov, Isaac Myers, T. Matsuyama, Y. Yamakawa, S. Yoshida, H. Ukai, Priti Shah, Yuichiro Tameda, S. Suzuki, Taka Tomida, T. Shirahama, John N. Matthews, Douglas Bergman, Pierre Sokolsky, R. Zollinger, D. Oku, K. Hiyama, Y. J. Kwon, Hiroyuki Sagawa, K. Ikuta, Hideyuki Ohoka, Hideaki Shimodaira, M. Takeda, J. H. Kim, M. Allen, T. J. Sonley, Shigehiro Nagataki, K. Oki, Charlie Jui, J. Ogura, Y. Kondo, Akimichi Taketa, Naoaki Hayashida, Y. Tsuyuguchi, K. Kasahara, K. Kitamoto, J. P. Lundquist, Takaaki Ishii, Toshiyuki Nonaka, Mayuko Minamino, K. Honda, S. Y. Roh, B. G. Cheon, Takeshi Okuda, Igor Tkachev, T. Iguchi, A. L. Sampson, D. C. Rodriguez, S. Iwamoto, John Belz, Inkyu Park, K. Miyata, Masaomi Ono, J. I. Shin, Yasunori Kitamura, K. Yamazaki, Bokkyun Shin, S. Kawakami, Y. Murano, Tareq Abu-Zayyad, Vladim Kuzmin, R. Yamane, T. Fujii, K. Tsutsumi, Hiroshi Yamaoka, R. Aida, Masaaki Tanaka, G. Vasiloff, R. Azuma, T. Matsuura, Elliott Barcikowski, T.-A. Shibata, L. M. Scott, K. Hibino, Jyunsei Chiba, Dongsu Ryu, Gordon Thomson, Tom Stroman, Robert Cady, Y. Hayashi, Hongsu Kim, Dmitri Ivanov, H. Fujii, Y. Uchihori, O. Kalashev, W. R. Cho, H. Kawai, Hyun-Il Kim, Kiyoshi Tanaka, H. Yoshii, Eiji Kido, Yoshiki Tsunesada, K. Kuramoto, Y. Yoneda, N. Inoue, S. I. Lim, Daisuke Ikeda, Toru Nakamura, Kenichi Kadota, S. R. Stratton, M. Ohnishi, S. Machida, S. Udo, J. Yang, Y. Wada, Tiffany Wong, J. Lan, S. B. Thomas, Nobuyuki Sakurai, S. W. Nam, T. Fukuda, Masaki Fukushima, Peter Tinyakov, Samuel Blake, Shoichi Ogio, E. J. Cho, Michiyuki Chikawa, Yasuhiro H. Takahashi, Zach Zundel, Masato Takita, K. Martens, Hideki Tanaka, H. Tokuno, J. D. Smith, R. W. Springer, Tomohiro Matsuda, K. Kobayashi, Shingo Kawana, William Hanlon, Maxim Pshirkov, K. Hayashi, Fumio Kakimoto, Akitoshi Oshima, Shunsuke Ozawa, and Ben Stokes

Subjects
Astroparticle physics, Physics, business.industry, Aperture, Monte Carlo method, Detector, Astronomy and Astrophysics, Cosmic ray, law.invention, Telescope, Optics, law, Ultra-high-energy cosmic ray, business, Event reconstruction
Abstract

We present a measurement of the energy spectrum of ultra-high-energy cosmic rays performed by the Telescope Array experiment using monocular observations from its two new FADC-based fluorescence detectors. After a short description of the experiment, we describe the data analysis and event reconstruction procedures. Since the aperture of the experiment must be calculated by Monte Carlo simulation, we describe this calculation and the comparisons of simulated and real data used to verify the validity of the aperture calculation. Finally, we present the energy spectrum calculated from the merged monocular data sets of the two FADC-based detectors, and also the combination of this merged spectrum with an independent, previously published monocular spectrum measurement performed by Telescope Array’s third fluorescence detector [T. Abu-Zayyad et al., The energy spectrum of Telescope Array’s middle drum detector and the direct comparison to the high resolution fly’s eye experiment, Astroparticle Physics 39 (2012) 109-119, http://dx.doi.org/10.1016/j.astropartphys.2012.05.012 , Available from: ]. This combined spectrum corroborates the recently published Telescope Array surface detector spectrum [T. Abu-Zayyad, et al., The cosmic-ray energy spectrum observed with the surface detector of the Telescope Array experiment, ApJ 768 (2013) L1, http://dx.doi.org/10.1088/2041-8205/768/1/L1 , Available from: ] with independent systematic uncertainties.

Published
2013

243. Alcohol and dietary folate intake and the risk of breast cancer

Author

Hidemi Ito, Satoyo Hosono, Kazuo Tajima, Keitaro Matsuo, Hiroji Iwata, Hideo Tanaka, Tania Islam, Kaoru Hirose, Miki Watanabe, and Aiko Sueta

Subjects
Adult, Risk, Cancer Research, medicine.medical_specialty, Alcohol Drinking, Receptor, ErbB-2, Epidemiology, Physiology, Breast Neoplasms, Folic Acid, Breast cancer, Internal medicine, Odds Ratio, Humans, Medicine, Risk factor, Aged, business.industry, Confounding, Public Health, Environmental and Occupational Health, Absolute risk reduction, Case-control study, Cancer, Odds ratio, Middle Aged, medicine.disease, Endocrinology, Receptors, Estrogen, Oncology, Case-Control Studies, Female, Breast disease, Receptors, Progesterone, business
Abstract

Owing to its interaction with alcohol, folate has been suggested to be a potential factor for many types of cancer. The impact of these factors on the risk of breast cancer among Asian populations has not been fully examined, however, particularly with respect to receptor status. We carried out a case-control study in premenopausal and postmenopausal Japanese women, including 1754 breast cancer patients and 3508 noncancer controls. We determined the association between self-reported alcohol drinking, dietary folate intake, and the risk of breast cancer. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using logistic models adjusted for potential confounders. Alcohol consumption was associated with the risk of breast cancer, with the OR for a drinker consuming 23 g or more per day relative to a nondrinker of 1.39 (95% CI: 1.07-1.80). A significant inverse association was observed between folate intake and overall risk of breast cancer, with an OR of 0.79 (95% CI: 0.68-0.93; Ptrend=0.004) for the highest tertile relative to the lowest. The OR of a drinker consuming 23 g or more per day relative to a nondrinker with a low folate intake was 1.58 (95% CI: 1.06-2.33). However, a significantly increased risk was not observed in tertile 2 and tertile 3 folate in taker with any amount of alcohol consumption. Higher folate intake decreases the risk of breast cancer among Japanese, whereas alcohol intake increases the risk. These two factors interact with each other, and the excess risk of breast cancer with alcohol consumption might be attenuated by increasing the intake of folate. In addition, the effects of folate/alcohol may vary according to the tumor subtype.

Published
2013

244. Genome-wide association study of genetic factors related to confectionery intake: Potential roles of theADIPOQgene

Author

Naoyuki Takashima, Kokichi Arisawa, Haruo Mikami, Guang Yin, Sadao Suzuki, Kazuo Tajima, Nobuyuki Hamajima, Mariko Naito, Michiaki Kubo, Keitaro Matsuo, Hideo Tanaka, Fumihiko Matsuda, Tatsuhiko Sakamoto, Ryo Yamada, Satoyo Hosono, Emi Morita, Takahisa Kawaguchi, Kenji Wakai, Hidemi Ito, Noriko Nakahata, Yasushi Yatabe, Meiko Takahashi, Keizo Ohnaka, and Yoshiyuki Watanabe

Subjects
Genetics, Nutrition and Dietetics, Adiponectin, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Genome-wide association study, Single-nucleotide polymorphism, Biology, ADIPOQ Gene, Endocrinology, Polymorphism (computer science), SNP, Genotyping, Allele frequency
Abstract

Objective: The excessive consumption of confectionery might have adverse effects on human health. To screen genetic factors associated with confectionery-intake frequency, a genome-wide association study (GWAS) in Japan was conducted. Design and Methods: For the discovery phase (stage 1), we conducted a GWAS of 939 noncancer patients in a cancer hospital. Additive models were used to test associations between genotypes of approximately 500,000 single-nucleotide polymorphisms (SNPs) and the confectionery-intake score (based on intake frequency). We followed-up association signals with P 0.01 in stage 1 by genotyping the SNPs of 4,491 participants in a cross-sectional study within a cohort (replication phase [stage 2]). Results: We identified 12 SNPs in stage 1 that were potentially related to confectionery intake. In stage 2, this association was replicated for one SNP (rs822396; P = 0.049 for stage 2 and 4.2 × 10−5 for stage 1+2) in intron 1 of the ADIPOQ gene, which encodes the adipokine adiponectin. Conclusions: Given the biological plausibility and previous relevant findings, the association of an SNP in the ADIPOQ gene with a preference for confectionery is worthy of follow-up and provides a good working hypothesis for experimental testing.

Published
2013

245. Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls

Author

Joe Dennis, Sarah Stewart-Brown, Per Hall, Hui Cai, Pei Ei Wu, Soo Chin Lee, Alison M. Dunning, Kenneth Muir, Wenjin Wang, Min Hyuk Lee, Francois Bacot, Hyuna Sung, Chiu-Chen Tseng, Zefang Ren, Hidemi Ito, Artitaya Lophatananon, Ben Zhang, Wei Lu, Kexin Chen, Jong Won Lee, Daniel O. Stram, Mi Kyung Kim, Wonshik Han, Chiun-Sheng Huang, Soo Hwang Teo, Ji Yeob Choi, David Van Den Berg, Hui Miao, Xiao-Ou Shu, Jiajun Shi, Wei Zheng, Mikael Hartman, Hongbing Shen, Jirong Long, Douglas F. Easton, Qin Wang, Javier Benitez, Chun Li, Hideo Tanaka, Jyh Cherng Yu, Bu Tian Ji, Motoki Iwasaki, Daniel C. Tessier, Thomas C. Putti, Daniel Vincent, Tien Yin Wong, Ming-Feng Hou, Ui-Soon Khoo, Keitaro Matsuo, Cheng Har Yip, Hiroji Iwata, Keun-Young Yoo, Dong Young Noh, Paul D.P. Pharoah, Anna H. Wu, Sung-Won Kim, In Nee Kang, Yong-Bing Xiang, Ying Zheng, Wanqing Wen, Jong-Young Lee, Pornthep Siriwanarangsan, Chen-Yang Shen, Suleeporn Sangrajrang, Daehee Kang, Aiko Sueta, Yu Tang Gao, Qiuyin Cai, Kyriaki Michailidou, Manjeet K. Humphreys, Sue K. Park, and Christopher A. Haiman

Subjects
Adult, Oncology, China, medicine.medical_specialty, Population, Estrogen receptor, Breast Neoplasms, Single-nucleotide polymorphism, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Asian People, Internal medicine, Republic of Korea, Genetics, medicine, Humans, Genetic Predisposition to Disease, education, Molecular Biology, Genetics (clinical), Aged, 030304 developmental biology, Genetic association, 0303 health sciences, education.field_of_study, Association Studies Articles, Case-control study, Cancer, General Medicine, Middle Aged, medicine.disease, 3. Good health, Receptors, Estrogen, Case-Control Studies, 030220 oncology & carcinogenesis, Female, Genome-Wide Association Study
Abstract

In a consortium including 23 637 breast cancer patients and 25 579 controls of East Asian ancestry, we investigated 70 single-nucleotide polymorphisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide association studies (GWASs) conducted primarily in European-ancestry populations. SNPs in 31 loci showed an association with breast cancer risk at P < 0.05 in a direction consistent with that reported previously. Twenty-one of them remained statistically significant after adjusting for multiple comparisons with the Bonferroni-corrected significance level of, published_or_final_version

Published
2013

246. Coffee consumption and the risk of colorectal cancer by anatomical subsite in Japan: Results from the HERPACC studies

Author

Hiroko, Nakagawa-Senda, Hidemi, Ito, Satoyo, Hosono, Isao, Oze, Hideo, Tanaka, and Keitaro, Matsuo

Subjects
Adult, Aged, 80 and over, Male, Middle Aged, Coffee, Logistic Models, Japan, Risk Factors, Case-Control Studies, Surveys and Questionnaires, Odds Ratio, Humans, Female, Colorectal Neoplasms, Aged
Abstract

Consumption of coffee, a popular beverage worldwide, has been associated with lower colorectal cancer (CRC) risk. Although CRC exhibits different biological characteristics by anatomical subsite, the possibly heterogeneous impact of coffee on CRC by anatomical subsite has remained unclear. Here, we conducted two case-control studies to examine the association between coffee consumption and CRC risk as well as risk by anatomic subsite among Japanese using data from the Hospital-based Epidemiological Research Program at Aichi Cancer Center I and II (HERPACC-I and II). Subjects were enrolled in HERPACC-I between 1988 and 2000 and in HERPACC-II between 2001 and 2005. Coffee consumption was measured with a self-administered questionnaire. A conditional logistic regression model was used to calculate odds ratios (ORs) of CRC with coffee consumption, adjusted for potential confounders of age, smoking, alcohol drinking, red meat intake, BMI, exercise, family history of CRC, and diabetes mellitus history. We estimated summary ORs by pooling study-specific ORs with a fixed effects model. In total, 2,696 CRC cases and 13,480 non-cancer outpatients as controls were included. Overall, compared to non-drinkers, ORs of less than 1 cup/day, 1-2 cups/day and 3 or more cups/day for CRC were 0.88 (95% CI: 0.77-1.00), 0.90 (95% CI: 0.80-1.01) and 0.78 (95% CI: 0.65-0.92), respectively (trend-p = 0.009). Subsite-specific analysis revealed a significant inverse linear trend between coffee consumption and distal colon cancer (p-trend = 0.048), and a tendency toward a lower risk of rectal cancer (p-trend = 0.068). These findings suggest that coffee consumption might impact the prevention of CRC, especially distal colon cancer.

Published
2016

247. Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk

Author

Ugo Boggi, Cosmeri Rizzato, Krzysztof Jamroziak, Andrea Mambrini, Gabriele Capurso, Yogesh K. Vashist, Valerio Pazienza, Christoph W. Michalski, Giulia Martina Cavestro, Keitaro Matsuo, Ewa Małecka-Panas, Jakob R. Izbicki, Harald Klüter, Timothy J. Key, Ludmila Vodickova, Vincenzo Corbo, Kenji Yamao, Domenica Gioffreda, Anna Stępień, Milena Di Leo, Willem Niesen, Audrius Ivanauskas, Cosimo Sperti, Carlo Federico Zambon, Peter Bugert, Beatrice Mohelnikova-Duchonova, Satoyo Hosono, Angelo Andriulli, Renata Talar-Wojnarowska, Maria Gazouli, John P. Neoptolemos, Franco Bambi, Francesca Tavano, Claudio Pasquali, Yasuhiro Shimizu, Manuela Pastore, Federico Canzian, Rudolf Kaaks, Daniele Campa, Gianfranco Delle Fave, Frederike Dijk, George Theodoropoulos, Raffaele Pezzilli, Paola Pacetti, Eithne Costello, Pavel Vodicka, Verena Katzke, Stefano Landi, Juozas Kupcinskas, Oliver Strobel, Martin Lovecek, Thilo Hackert, Manuel Gentiluomo, Markus W. Büchler, Pavel Soucek, Roberto Valente, Bas Bueno-de-Mesquita, Hidemi Ito, Kay-Tee Khaw, Olivier R. Busch, Daniela Basso, Campa, D, Pastore, M, Gentiluomo, M, Talar Wojnarowska, R, Kupcinskas, J, Malecka Panas, E, Neoptolemos, Jp, Niesen, W, Vodicka, P, Delle Fave, G, Bas Bueno de Mesquita, H, Gazouli, M, Pacetti, P, Di Leo, M, Ito, H, Klüter, H, Soucek, P, Corbo, V, Yamao, K, Hosono, S, Kaaks, R, Vashist, Y, Gioffreda, D, Strobel, O, Shimizu, Y, Dijk, F, Andriulli, A, Ivanauskas, A, Bugert, P, Tavano, F, Vodickova, L, Zambon, Cf, Lovecek, M, Landi, S, Key, Tj, Boggi, U, Pezzilli, R, Jamroziak, K, Mohelnikova Duchonova, B, Mambrini, A, Bambi, F, Busch, O, Pazienza, V, Valente, R, Theodoropoulos, G, Hackert, T, Capurso, G, Cavestro, GIULIA MARTINA, Pasquali, C, Basso, D, Sperti, C, Matsuo, K, Büchler, M, Khaw, Kt, Izbicki, J, Costello, E, Katzke, V, Michalski, C, Stepien, A, Rizzato, C, Canzian, F., CCA -Cancer Center Amsterdam, Pathology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and Surgery

Subjects
0301 basic medicine, Pancreatic disease, CDKN2A, association study, miRSNP, pancreatic cancer, single nucleotide polymorphisms, Alleles, Asian Continental Ancestry Group, Binding Sites, Carcinoma, Pancreatic Ductal, Case-Control Studies, Cyclin-Dependent Kinase Inhibitor p15, Cyclin-Dependent Kinase Inhibitor p18, DNA Methylation, Disease Progression, European Continental Ancestry Group, Genetic Predisposition to Disease, Genotype, Germ-Line Mutation, Humans, International Cooperation, Japan, Odds Ratio, Pancreatic Neoplasms, Prognosis, Retrospective Studies, Polymorphism, Single Nucleotide, Bioinformatics, 0302 clinical medicine, Medicine, Single Nucleotide, 3. Good health, Oncology, Pancreatic Ductal, 030220 oncology & carcinogenesis, Research Paper, Single-nucleotide polymorphism, White People, 03 medical and health sciences, Germline mutation, Asian People, Pancreatic cancer, Allele, Polymorphism, Cyclin-Dependent Kinase Inhibitor p16, business.industry, Carcinoma, Cancer, medicine.disease, 030104 developmental biology, Cancer research, business
Abstract

The CDKN2A(p16) gene plays a key role in pancreatic cancer etiology. It is one of the most commonly somatically mutated genes in pancreatic cancer, rare germline mutations have been found to be associated with increased risk of developing familiar pancreatic cancer and CDKN2A promoter hyper-methylation has been suggested to play a critical role both in pancreatic cancer onset and prognosis. In addition several unrelated SNPs in the 9p21.3 region, that includes the CDNK2A, CDNK2B and the CDNK2B-AS1 genes, are associated with the development of cancer in various organs. However, association between the common genetic variability in this region and pancreatic cancer risk is not clearly understood. We sought to fill this gap in a case-control study genotyping 13 single nucleotide polymorphisms (SNPs) in 2,857 pancreatic ductal adenocarcinoma (PDAC) patients and 6,111 controls in the context of the Pancreatic Disease Research (PANDoRA) consortium. We found that the A allele of the rs3217992 SNP was associated with an increased pancreatic cancer risk (OR het=1.14, 95% CI 1.01-1.27, p=0.026, ORhom =1.30, 95% CI 1.12-1.51, p=0.00049). This pleiotropic variant is reported to be a mir-SNP that, by changing the binding site of one or more miRNAs, could influence the normal cell cycle progression and in turn increase PDAC risk. In conclusion, we observed a novel association in a pleiotropic region that has been found to be of key relevance in the susceptibility to various types of cancer and diabetes suggesting that the CDKN2A/Blocus could represent a genetic link between diabetes and pancreatic cancer risk.

Published
2016

248. Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus

Author

Kenneth Offit, Hoda Anton-Culver, Ans M.W. van den Ouweland, Siranoush Manoukian, Christine L. Clarke, Kyriaki Michailidou, Antonis C. Antoniou, Maria Kabisch, Isabel dos-Santos-Silva, Douglas F. Easton, Curtis Olswold, Graham G. Giles, Tien Yin Wong, Ursula Eilber, Mads Thomassen, Christopher A. Haiman, Alice J. Sigurdson, Lothar Haeberle, Florence Menegaux, Ana Osorio, Marco Montagna, Katarzyna Jaworska-Bieniek, Eitan Friedman, Simon S. Cross, Daniel Barrowdale, Elinor J. Sawyer, Adam N. Freeman, Caroline Seynaeve, Min Hyuk Lee, Arnaud Droit, Per Hall, Minouk J. Schoemaker, Trinidad Caldés, Peter Hillemanns, Frederik Marmé, Jenny Lester, Michele M. Doody, Bernard Peissel, Peter Kraft, Elza Khusnutdinova, Anna H. Wu, Stéphanie Peeters, Georg Pfeiler, Pascal Guénel, Hidemi Ito, Xingyi Guo, Antoinette Hollestelle, Heli Nevanlinna, Kathleen Claes, Ylva Paulsson-Karlsson, Cecilia M. Dorfling, Roger L. Milne, Daehee Kang, Judith S. Brand, Diether Lambrechts, Olufunmilayo I. Olopade, Simona Agata, Saundra S. Buys, Muhammad Usman Rashid, Fabienne Lesueur, Alicia Beeghly-Fadiel, Peter Devilee, Manjeet K. Bolla, Natalia Antonenkova, Irene Konstantopoulou, Claudine Isaacs, Anja Rudolph, Carl Blomqvist, Tjoung Won Park-Simon, Judy Garber, Csilla Szabo, Francois Bacot, Arto Mannermaa, Yu-Tang Gao, Stig E. Bojesen, Susan L. Neuhausen, Marina Bermisheva, Qiuyin Cai, Zakaria Einbeigi, Christian F. Singer, Qin Wang, Kerstin Rhiem, Sofia Khan, Fiona Lalloo, Robert L. Nussbaum, Thilo Dörk, William J. Blot, Sylvie Mazoyer, Julia A. Knight, Katherine L. Nathanson, Clare Turnbull, Nazneen Rahman, Anne Lise Børresen-Dale, Chuen Neng Lee, Annegien Broeks, Martha J. Shrubsole, Ava Kwong, Jirong Long, Ian G. Campbell, Sara Margolin, Fergus J. Couch, Laima Tihomirova, Mary Beth Terry, Jenny Chang-Claude, Alice S. Whittemore, Joseph Vijai, Alfons Meindl, Xiao-Ou Shu, Shan Wang-Gohrke, Wei Zheng, Beth Y. Karlan, Jacques Simard, Angela Cox, Shahana Ahmed, Polly A. Newcomb, Ritu Salani, Chen-Yang Shen, Adalgeir Arason, Sandrine Tchatchou, Ute Hamann, Elizabeth J. van Rensburg, Michael Jones, Mark H. Greene, Anthony J. Swerdlow, Senno Verhoef, Jonine Figueroa, Hermann Brenner, Volker Arndt, Charles Joly Beauparlant, Esther M. John, Nadege Presneau, Jingmei Li, Laura Papi, Marjanka K. Schmidt, Montserrat Garcia-Closas, Uffe Birk Jensen, Georgia Chenevix-Trench, Paolo Peterlongo, Penny Soucy, Thomas Brüning, Jaana M. Hartikainen, Siddhartha Kar, Ji Yeob Choi, Manuel R. Teixeira, Phuong L. Mai, Alex Teulé, Jyh Cherng Yu, Paul Brennan, Maya Ghoussaini, Edith Olah, Henrik Flyger, Michael Friedlander, Soo Hwang Teo, Frans B. L. Hogervorst, Kathleen M. Egan, David J. Hunter, Kristiina Aittomäki, Joe Dennis, Anna González-Neira, Mikael Hartman, Alison M. Dunning, Doris Steinemann, Debra Frost, Melissa C. Southey, Ramunas Janavicius, Evgeny N. Imyanitov, Catherine M. Phelan, Amanda E. Toland, Anna Marie Mulligan, David ven den Berg, Rita K. Schmutzler, Julian Peto, Irene L. Andrulis, Chenjie Zeng, Kenneth Muir, Peter Schürmann, Saila Kauppila, Banu Arun, Jane Carpenter, Jeffrey N. Weitzel, Yael Laitman, Susan M. Domchek, Robert Winqvist, Caroline Baynes, Brita Arver, Marc Tischkowitz, Kamila Czene, Keitaro Matsuo, Barbara Burwinkel, Miriam Dwek, Kim De Leeneer, David E. Goldgar, Anna Jakubowska, Paul D.P. Pharoah, Peter A. Fasching, Bernd Dworniczak, Susan J. Ramus, Lesley McGuffog, Andrea Gehrig, Michael J. Kerin, Thomas Hansen, Francesca Damiola, John L. Hopper, Loic Le Marchand, Peter J. Hulick, Annika Lindblom, Emily Hallberg, Miguel de la Hoya, Gaetana Gambino, Martine Dumont, Susan L. Slager, Bernardo Bonanni, Bent Ejlertsen, Norhashimah Hassan, Sue Healey, Orland Diez, Mary B. Daly, Carolyn B. Hendricks, Artitaya Lophatananon, Annelie Liljegren, Steven N. Hart, Jan Lubinski, Natalia Bogdanova, Drakoulis Yannoukakos, Steve Ellis, Silje Nord, Hiltrud Brauch, Gad Rennert, Conxi Lázaro, Daniel C. Tessier, Paolo Radice, Dominique Stoppa-Lyonnet, Nadine Tung, Andrew K. Godwin, Suleeporn Sangrajrang, Karoline Kuchenbaecker, Javier Benitez, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON), Medicum, Kristiina Aittomäki / Principal Investigator, Department of Medical and Clinical Genetics, Clinicum, Department of Oncology, Department of Obstetrics and Gynecology, School of Medicine / Clinical Medicine, Wang, Jean [0000-0002-9139-0627], Dennis, Joe [0000-0003-4591-1214], Tischkowitz, Marc [0000-0002-7880-0628], Pharoah, Paul [0000-0001-8494-732X], Dunning, Alison [0000-0001-6651-7166], Antoniou, Antonis [0000-0001-9223-3116], Easton, Douglas [0000-0003-2444-3247], Apollo - University of Cambridge Repository, Clinical Genetics, Medical Oncology, and Obstetrics & Gynecology

Subjects
0301 basic medicine, Fine-scale mapping, Genome-wide association study, HORMONE-RELATED PROTEIN, Epigenesis, Genetic, Breast cancer, Medizinische Fakultät, Databases, Genetic, Genotype, BRCA2 MUTATION CARRIERS, Odds Ratio, Medicine and Health Sciences, Pair 12, Medicine, Genetic risk factor, Promoter Regions, Genetic, Medicine(all), Genetics, BRCA1 Protein, PTHLH-CCDC91, Chromosome Mapping, LOCALIZATION, Single Nucleotide, PTHLH, 3. Good health, Enhancer Elements, Genetic, Population Surveillance, Female, Medical Genetics, BRAC1 mutation carriers, CCDC91, Alleles, Breast Neoplasms, Case-Control Studies, Computational Biology, European Continental Ancestry Group, Haplotypes, Heterozygote, Humans, Mutation, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk, Chromosomes, Human, Pair 12, Genetic Predisposition to Disease, Genome-Wide Association Study, Human, Research Article, EXPRESSION, Enhancer Elements, SUSCEPTIBILITY LOCI, 3122 Cancers, Single-nucleotide polymorphism, Chromosomes, White People, OVARIAN-CANCER, Càncer de mama, Promoter Regions, Databases, 03 medical and health sciences, Research Support, N.I.H., Extramural, SDG 3 - Good Health and Well-being, Genetic, Journal Article, ddc:610, Polymorphism, GENOME-WIDE ASSOCIATION, Medicinsk genetik, Genetic association, Cancer och onkologi, business.industry, Haplotype, Case-control study, Biology and Life Sciences, Odds ratio, medicine.disease, ENHANCERS, 030104 developmental biology, Cancer and Oncology, METASTASIS, 3111 Biomedicine, GENETIC MODIFIERS, business, Genètica, Epigenesis
Abstract

Article, Background Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. Method We performed a fine-scale mapping study of a 700 kb region including 441 genotyped and more than 1300 imputed genetic variants in 48,155 cases and 43,612 controls of European descent, 6269 cases and 6624 controls of East Asian descent and 1116 cases and 932 controls of African descent in the Breast Cancer Association Consortium (BCAC; http://bcac.ccge.medschl.cam.ac.uk/), and in 15,252 BRCA1 mutation carriers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Stepwise regression analyses were performed to identify independent association signals. Data from the Encyclopedia of DNA Elements project (ENCODE) and the Cancer Genome Atlas (TCGA) were used for functional annotation. Results Analysis of data from European descendants found evidence for four independent association signals at 12p11, represented by rs7297051 (odds ratio (OR) = 1.09, 95 % confidence interval (CI) = 1.06–1.12; P = 3 × 10-9), rs805510 (OR = 1.08, 95 % CI = 1.04–1.12, P = 2 × 10-5), and rs1871152 (OR = 1.04, 95 % CI = 1.02–1.06; P = 2 × 10-4) identified in the general populations, and rs113824616 (P = 7 × 10-5) identified in the meta-analysis of BCAC ER-negative cases and BRCA1 mutation carriers. SNPs rs7297051, rs805510 and rs113824616 were also associated with breast cancer risk at P, published version, peerReviewed

Published
2016

249. Changes in trends in colorectal cancer incidence rate by anatomic site between 1978 and 2004 in Japan

Author

Hidemi Ito, Haruo Mikami, Hiromi Sugiyama, Masakazu Hattori, Kayo Nakata, Yoshikazu Nishino, Hideo Tanaka, Isao Oze, Hiroko Nakagawa, and Satoyo Hosono

Subjects
Male, Cancer Research, medicine.medical_specialty, Time Factors, Epidemiology, Colorectal cancer, Population, Rectum, Anatomic Site, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Sex Factors, Japan, Internal medicine, medicine, Asian country, Humans, Registries, education, Survival rate, Aged, education.field_of_study, business.industry, Incidence (epidemiology), Incidence, Public Health, Environmental and Occupational Health, Age Factors, Cancer, Middle Aged, medicine.disease, Prognosis, Surgery, Survival Rate, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, business, Colorectal Neoplasms, Follow-Up Studies
Abstract

Although colorectal cancer (CRC), a major type of cancer worldwide, has shown a proximal or right-sided shift in subsite distribution in western countries, trends in subsite incidence in Asian countries remain unclear. Here, we evaluated subsite-specific trends in CRC incidence rate between 1978 and 2004 in Japan using large data from 10 population-based cancer registries. The colorectal sites (C18-C20) were categorized into three groups: proximal colon (C18.0-C18.5), distal colon (C18.6-C18.7), and rectum (C19.9 and C20.9). Trends in age-standardized incidence rates (ASRs) were characterized by joinpoint regression analysis. A total of 303 802 CRC cases were analyzed. Overall, ASRs increased remarkably until 1993, with an annual percentage change (APC) of 4.9%, and then stabilized thereafter. By subsite, however, ASRs of proximal colon significantly increased, with APCs of 7.1% (1978-1991), 3.8% (1991-1996), and 0.9% (1996-2004); distal colon showed an initial significant increase, with an APC of 7.6%, but stabilized from 1991 until the end of observation; and rectal cancer showed an initial significant increase, with APCs of 1.9% (1978-1988) and 5.6% (1988-1992), but then decreased abruptly in 1992, the year CRC screening was introduced nationwide, with an APC of -1.0%. Thus, we revealed that changes in incidence trends for the three anatomic sites apparently began to differ in the 1990s. Careful monitoring is necessary to confirm whether these trends are changing in the Japanese population.

Published
2016

250. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

Author

Jirong Long, Simon S. Cross, Marc Tischkowitz, Beth Y. Karlan, Trinidad Caldés, Fergus J. Couch, Charlotte Sagne, Ute Hamann, Olga M. Sinilnikova, Maria Kabisch, Richard C Sallari, Gad Rennert, Daniel Barrowdale, Elinor J. Sawyer, Anthony J. Swerdlow, Jenny Lester, Åke Borg, Anders Bojesen, Rosa B. Barkardottir, Simon A. Gayther, Heli Nevanlinna, Judy Garber, Norbert Arnold, Vilde Drageset Haakensen, Vessela N. Kristensen, Christopher G. Scott, Daehee Kang, Gillian Mitchell, Eitan Friedman, Laura Ottini, Diether Lambrechts, Manjeet K. Bolla, Robert L. Nussbaum, Tomasz Huzarski, Dieter Niederacher, Angela Cox, Rachel Laframboise, Maartje J. Hooning, Volker Arndt, Penny Soucy, Marjanka K. Schmidt, William Blot, Soo Hwang Teo, Anne Lise Børresen-Dale, Maria A. Caligo, Ana Osorio, Orland Diez, Gertraud Maskarinec, Johanna Rantala, Kelly-Anne Phillips, Pascal Guénel, Hidemi Ito, Miquel Angel Pujana, Anna H. Wu, Christy G. Woolcott, Maya Ghoussaini, Hatef Darabi, Sander Canisius, Kay-Tee Khaw, Irene Konstantopoulou, Carl Blomqvist, Christine Rappaport, Joan Brunet, Hermann Brenner, Sylvie Mazoyer, Irene L. Andrulis, Nicholas A Sinnott-Armstrong, Javier Benitez, Claudine Isaacs, Mahdi Moradi Marjaneh, Joseph Vijai, Jennifer Stone, Qin Wang, Caroline Seynaeve, Patricia A. Ganz, Sara Margolin, Paolo Radice, Janet E. Olson, Soo-Chin Lee, Mark H. Greene, Laura Papi, Carmel Apicella, Ava Kwong, Mitul Shah, Matthias W. Beckmann, Yael Laitman, Hoda Anton-Culver, Ans M.W. van den Ouweland, Sue K. Park, Annegien Broeks, Georgia Chenevix-Trench, Jonathan Beesley, Nadja Bogdanova-Markov, Paolo Peterlongo, Paraskevi Apostolou, Bernardo Bonanni, Frederik Marmé, Veli-Matti Kosma, Alfons Meindl, Brian E. Henderson, Rulla M. Tamimi, Siranoush Manoukian, Bent Ejlertsen, Miroslav Kapuscinski, Juliet D. French, Mark E. Sherman, Ji Yeob Choi, Graham G. Giles, Stacey L. Edwards, Evgeny N. Imyanitov, Kamila Czene, Thomas Hansen, Nick Orr, Susanne Kaufmann, Lenka Foretova, Celine M. Vachon, Edith Olah, Anja Rudolph, Arto Mannermaa, Phuong L. Mai, Isabel dos-Santos-Silva, Haran Sivakumaran, Francesca Damiola, Christian F. Singer, Muhammad Usman Rashid, Ed Dicks, Mikael Hartman, Antonis C. Antoniou, Dominique Stoppa-Lyonnet, Douglas F. Easton, Alison M. Dunning, John L. Hopper, Nadine Tung, Annika Lindblom, Kristiina Aittomäki, Kenneth Muir, Sue Healey, Cheng Har Yip, Mads Thomassen, Melissa C. Southey, Ramunas Janavicius, Cecilia M. Dorfling, Christine B. Ambrosone, Siddhartha Kar, Mary B. Daly, Artitaya Lophatananon, Rachel Rando, Banu Arun, Christopher A. Haiman, Catherine M. Phelan, Margaret Hills, Manuel R. Teixeira, Diana Torres, Hans Wildiers, Andrew K. Godwin, Keith Humphreys, Katri Pylkäs, Monika Jarosz, Susan L. Neuhausen, Montserrat Garcia-Closas, Robert Winqvist, Joe Dennis, Sook-Yee Yoon, Wei Zheng, Mitch Dowsett, Gord Glendon, Natasha Bogdanova, Suleeporn Sangrajrang, Steve Ellis, Paul Brennan, Lee Eunjung, Keitaro Matsuo, Jacek Gronwald, David E. Goldgar, Debra Frost, Chiu-Chen Tseng, Henrik Flyger, Kristine M. Hillman, Susan M. Domchek, Elena Lopez-Knowles, Bernard Peissel, Anna von Wachenfeldt, Karoline Kuchenbaecker, Anna Jakubowska, Paul D.P. Pharoah, Jose Ignacio Arias Perez, Kim De Leeneer, Roger L. Milne, Peter A. Fasching, Louise Izatt, Saundra S. Buys, Lesley McGuffog, Elizabeth J. van Rensburg, Pei-Ei Wu, Peter Devilee, Åslaug Helland, Qiuyin Cai, Peter J. Hulick, Miguel de la Hoya, Esther M. John, Kerstin Rhiem, Jan Lubinski, Karen A. Pooley, Marion Piedmonte, Catherine S. Healey, Mark S. Goldberg, Xiao-Ou Shu, Antoinette Hollestelle, Mary Beth Terry, Jenny Chang-Claude, Silje Nord, Chen-Yang Shen, Hiltrud Brauch, Kathleen Claes, Jason Sang Hun Lee, Sofia Khan, Katherine L. Nathanson, Hans Ehrencrona, Olufunmilayo I. Olopade, Stig E. Bojesen, Matti A. Rookus, Andrew Lee, Rita K. Schmutzler, Julian Peto, Jeffrey N. Weitzel, Barbara Burwinkel, Arjen R. Mensenkamp, Jacques Simard, Yu-Tang Gao, Robert Luben, S. Drury, Thilo Dörk, Laima Tihomirova, Per Hall, Barbara Perkins, Simona Agata, Jonine D. Figueroa, Julia A. Knight, Kenneth Offit, Kyriaki Michailidou, Anna González-Neira, Ian Tomlinson, Thérèse Truong, Amanda E. Toland, Anna Marie Mulligan, Noralane M. Lindor, Deborah J. Thompson, Marco Montagna, Clinical Genetics, Medical Oncology, Obstetrics & Gynecology, Dunning, Alison [0000-0001-6651-7166], Thompson, Deborah [0000-0003-1465-5799], Pooley, Karen [0000-0002-1274-9460], Dicks, Ed [0000-0002-0617-0401], Dennis, Joe [0000-0003-4591-1214], Wang, Jean [0000-0002-9139-0627], Ghoussaini, Maya [0000-0002-2415-2143], Lee, Andrew [0000-0003-0677-0252], Tischkowitz, Marc [0000-0002-7880-0628], Luben, Robert [0000-0002-5088-6343], Khaw, Kay-Tee [0000-0002-8802-2903], Pharoah, Paul [0000-0001-8494-732X], Antoniou, Antonis [0000-0001-9223-3116], Easton, Douglas [0000-0003-2444-3247], Apollo - University of Cambridge Repository, Targeted Gynaecologic Oncology (TARGON), Damage and Repair in Cancer Development and Cancer Treatment (DARE), and [ 1 ] Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England [ 2 ] Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England [ 3 ] QIMR Berghofer Med Res Inst, Canc Div, Brisbane, Qld, Australia [ 4 ] Breakthrough Breast Canc Res Ctr, Breast Canc Res, London, England [ 5 ] Royal Marsden Hosp, Acad Biochem, London SW3 6JJ, England [ 6 ] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA [ 7 ] MIT, Comp Sci & Artificial Intelligence Lab, 77 Massachusetts Ave, Cambridge, MA 02139 USA [ 8 ] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Amsterdam, Netherlands [ 9 ] Univ Melbourne, Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia [ 10 ] Univ Melbourne, Dept Pathol, Melbourne, Vic, Australia [ 11 ] Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry CV4 7AL, W Midlands, England [ 12 ] Univ Manchester, Inst Populat Hlth, Manchester, Lancs, England [ 13 ] Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Gynecol & Obstet, Comprehens Canc Ctr Erlangen Nuremberg Metropolit, D-91054 Erlangen, Germany [ 14 ] Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol & Oncol, Dept Med, Los Angeles, CA 90095 USA [ 15 ] London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1, England [ 16 ] Kings Coll London, Guys Hosp, Div Canc Studies, Res Oncol, London, England [ 17 ] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England [ 18 ] Univ Oxford, Oxford Biomed Res Ctr, Oxford, England [ 19 ] German Canc Res Ctr, Div Mol Genet Epidemiol, Heidelberg, Germany [ 20 ] German Canc Res Ctr, Mol Epidemiol Grp, Heidelberg, Germany [ 21 ] Heidelberg Univ, Natl Ctr Tumor Dis, Heidelberg, Germany [ 22 ] Heidelberg Univ, Dept Obstet & Gynecol, Heidelberg, Germany [ 23 ] INSERM, Ctr Res Epidemiol & Populat Hlth, Environm Epidemiol Canc, Villejuif, France [ 24 ] Univ Paris Sud, Villejuif, France [ 25 ] Copenhagen Univ Hosp, Herlev Hosp, Copenhagen Gen Populat Study, Herlev, Denmark [ 26 ] Copenhagen Univ Hosp, Herlev Hosp, Dept Clin Biochem, Herlev, Denmark [ 27 ] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark [ 28 ] Copenhagen Univ Hosp, Herlev Hosp, Dept Breast Surg, Herlev, Denmark [ 29 ] Spanish Natl Canc Ctr CNIO, Human Canc Genet Program, Madrid, Spain [ 30 ] Hosp Monte Naranco, Serv Cirugia Gen & Especialidades, Oviedo, Spain [ 31 ] Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA [ 32 ] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA [ 33 ] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany [ 34 ] German Canc Res Ctr, German Canc Consortium, Heidelberg, Germany [ 35 ] Tech Univ Munich, Dept Obstet & Gynaecol, D-80290 Munich, Germany [ 36 ] Univ Hosp Cologne, Dept Obstet & Gynaecol, Div Mol Gynecooncol, Cologne, Germany [ 37 ] Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany [ 38 ] Univ Hosp, Ctr Integrated Oncol, Cologne, Germany [ 39 ] Dr Margarete Fischer Bosch Inst Clin Pharmacol, Auerbachstr 112, Stuttgart, Germany [ 40 ] Univ Tubingen, Tubingen, Germany [ 41 ] German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany [ 42 ] Helsinki Univ Cent Hosp, Dept Clin Genet, Helsinki, Finland [ 43 ] Univ Helsinki, Helsinki Univ Cent Hosp, Dept Oncol, Helsinki, Finland [ 44 ] Aichi Canc Ctr Res Inst, Div Epidemiol & Prevent, Aichi, Japan [ 45 ] Aichi Canc Ctr Res Inst, Div Mol Med, Nagoya, Aichi, Japan [ 46 ] Hannover Med Sch, Radiat Oncol Res Unit, Hannover, Germany [ 47 ] Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany [ 48 ] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden [ 49 ] Karolinska Univ Hosp, Dept Oncol Pathol, Stockholm, Sweden [ 50 ] Kuopio Univ Hosp, Ctr Canc, SF-70210 Kuopio, Finland [ 51 ] Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland [ 52 ] Kuopio Univ Hosp, Dept Clin Pathol, Imaging Ctr, SF-70210 Kuopio, Finland [ 53 ] Vesalius Res Ctr, Leuven, Belgium [ 54 ] Univ Leuven, Dept Oncol, Lab Translat Genet, Leuven, Belgium [ 55 ] Univ Hosp Leuven, Dept Gen Med Oncol, Multidisciplinary Breast Ctr, Leuven, Belgium [ 56 ] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany [ 57 ] Univ Med Ctr Hamburg Eppendorf, UCCH, Hamburg, Germany [ 58 ] Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy [ 59 ] Fdn IRCCS Ist Nazl Tumori, Dept Prevent & Predict Med, Unit Mol Basis Genet Risk & Genet Testing, Milan, Italy [ 60 ] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA [ 61 ] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia [ 62 ] McGill Univ, Dept Med, Montreal, PQ, Canada [ 63 ] McGill Univ, Royal Victoria Hosp, Div Clin Epidemiol, Montreal, PQ H3A 1A1, Canada [ 64 ] Sime Darby Med Ctr, Canc Res Initiat Fdn, Subang Jaya, Malaysia [ 65 ] Univ Malaya, Med Ctr, Canc Res Inst, Breast Canc Res Unit, Kuala Lumpur, Malaysia [ 66 ] Radiumhospitalet, Oslo Univ Hosp, Inst Canc Res, Dept Genet, Oslo, Norway [ 67 ] Univ Oslo, Inst Clin Med, Oslo, Norway [ 68 ] Univ Oslo, Oslo Univ Hosp, Dept Clin Mol Biol, Oslo, Norway [ 69 ] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med, Nashville, TN 37212 USA [ 70 ] Univ Oulu, NordLab Oulu Univ Hosp, Dept Clin Chem, Lab Canc Genet & Tumor Biol, Oulu, Finland [ 71 ] Univ Oulu, NordLab Oulu Univ Hosp, Bioctr Oulu, Oulu, Finland [ 72 ] Northern Finland Lab Ctr NordLab, Lab Canc Genet & Tumor Biol, Oulu, Finland [ 73 ] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada [ 74 ] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada [ 75 ] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Prosserman Ctr Hlth Res, Toronto, ON M5G 1X5, Canada [ 76 ] Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada [ 77 ] Leiden Univ Med Ctr, Dept Pathol, Leiden, Netherlands [ 78 ] Leiden Univ Med Ctr, Dept Human Genet, Leiden, Netherlands [ 79 ] Erasmus MC, Dept Med Oncol, Rotterdam, Netherlands [ 80 ] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA [ 81 ] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden [ 82 ] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands [ 83 ] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China [ 84 ] Univ Sheffield, Sheffield Canc Res, Dept Oncol, Sheffield, S Yorkshire, England [ 85 ] Univ Sheffield, Dept Neurosci, Acad Unit Pathol, Sheffield, S Yorkshire, England [ 86 ] Int Epidemiol Inst, Rockville, MD USA [ 87 ] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea [ 88 ] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea [ 89 ] Seoul Natl Univ, Coll Med, Canc Res Inst, Seoul, South Korea [ 90 ] Natl Univ Hlth Syst, Dept Haematol Oncol, Singapore, Singapore [ 91 ] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117548, Singapore [ 92 ] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore [ 93 ] Natl Univ Hlth Syst, Dept Surg, Singapore, Singapore [ 94 ] Pontificia Univ Javerianar, Inst Human Genet, Bogota, Colombia [ 95 ] Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland [ 96 ] Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon, France [ 97 ] Natl Canc Inst, Bangkok, Thailand [ 98 ] Roswell Pk Canc Inst, Buffalo, NY 14263 USA [ 99 ] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA [ 100 ] China Med Univ, Sch Publ Hlth, Taichung, Taiwan [ 101 ] Acad Sinica, Inst Biomed Sci, Taiwan Biobank, Taipei, Taiwan [ 102 ] Inst Canc Res, Breakthrough Breast Canc Res Ctr, Div Canc Studies, London SW3 6JB, England [ 103 ] Inst Canc Res, Div Genet & Epidemiol, London SW3 6JB, England [ 104 ] Inst Canc Res, Div Breast Canc Res, London SW3 6JB, England [ 105 ] Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia [ 106 ] Canc Prevent Inst Calif, Dept Epidemiol, Fremont, CA USA [ 107 ] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA [ 108 ] Fox Chase Canc Ctr, Dept Clin Genet, 7701 Burholme Ave, Philadelphia, PA 19111 USA [ 109 ] Univ Utah, Sch Med, Dept Dermatol, Huntsman Canc Inst, Salt Lake City, UT USA [ 110 ] Univ Utah, Sch Med, Dept Med, Huntsman Canc Inst, Salt Lake City, UT USA [ 111 ] State Res Inst Ctr Innovat Med, Vilnius, Lithuania [ 112 ] Latvian Biomed Res & Study Ctr, Riga, Latvia [ 113 ] Beth Israel Deaconess Med Ctr, Dept Med Oncol, Boston, MA 02215 USA [ 114 ] Univ Pretoria, Dept Genet, ZA-0002 Pretoria, South Africa [ 115 ] Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA USA [ 116 ] Copenhagen Univ Hosp, Rigshosp, Dept Oncol, Copenhagen, Denmark [ 117 ] Copenhagen Univ Hosp, Rigshosp, Ctr Genom Med, Copenhagen, Denmark [ 118 ] Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain [ 119 ] Biomed Network Rare Dis CIBERER, Madrid, Spain [ 120 ] Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Program, Human Genotyping CEGEN Unit, Madrid, Spain [ 121 ] City Hope Clin Canc Genom Community Res Network, Duarte, CA USA [ 122 ] City Hope Natl Med Ctr, Clin Canc Genet, Duarte, CA USA [ 123 ] Ist Europeo Oncol, Div Canc Prevent & Genet, Milan, Italy [ 124 ] Ist Nazl Tumori, Fdn Ist Ricovero & Cura Carattere Sci, Dept Prevent & Predict Med, Unit Med Genet, Via Venezian 1, I-20133 Milan, Italy [ 125 ] Univ Florence, Dept Biomed Expt & Clin Sci, Unit Med Genet, Florence, Italy [ 126 ] Univ Roma La Sapienza, Dept Mol Med, Piazzale Aldo Moro 5, I-00185 Rome, Italy [ 127 ] Aghia Paraskevi Attikis, Natl Ctr Sci Res Demokritos, INRASTES Inst Nucl & Radiol Sci & Technol, Mol Diagnost Lab, Athens, Greece [ 128 ] Dana Farber Canc Inst, Canc Risk & Prevent Clin, Boston, MA 02115 USA [ 129 ] Shaukat Khanum Mem Canc Hosp & Res Ctr, Dept Basic Sci, Lahore, Pakistan [ 130 ] Guys & St Thomas Natl Hlth Serv NHS Fdn Trust, Clin Genet, London, England [ 131 ] Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA [ 132 ] Univ Kiel, Univ Hosp Schleswig Holstein, Dept Gynaecol & Obstet, Campus Kiel, Kiel, Germany [ 133 ] Univ Dusseldorf, Dusseldorf, Germany [ 134 ] Univ Hosp Cologne, Ctr Mol Med Cologne, Dept Obstet & Gynaecol, Ctr Familial Breast & Ovarian Canc, Cologne, Germany [ 135 ] Univ Hosp Cologne, Ctr Mol Med Cologne, Ctr Integrated Oncol, Cologne, Germany [ 136 ] Univ Munster, Inst Human Genet, D-48149 Munster, Germany [ 137 ] Univ Lyon 1, CNRS UMR 5286, INSERM U1052, Ctr Rech Cancerol Lyon, F-69365 Lyon, France [ 138 ] Inst Curie, Dept Tumour Biol, Paris, France [ 139 ] Univ Paris 05, Sorbonne Paris Cite, Paris, France [ 140 ] Hosp Civils Lyon, Ctr Leon Berard, Unite Mixte Genet Constitutionnelle Canc Frequent, Lyon, France [ 141 ] Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA [ 142 ] Univ Ghent, Ctr Med Genet, B-9000 Ghent, Belgium [ 143 ] Hosp Clin San Carlos, IdISSC, Mol Oncol Lab, Madrid, Spain [ 144 ] Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland [ 145 ] Univ Helsinki, Cent Hosp, Helsinki, Finland [ 146 ] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands [ 147 ] Erasmus Univ, Med Ctr, Family Canc Clin, Dept Med Oncol, Rotterdam, Netherlands [ 148 ] Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands [ 149 ] Hong Kong Sanat & Hosp, Canc Genet Ctr, Hong Kong Hereditary Breast Canc Family Registry, Hong Kong, Hong Kong, Peoples R China [ 150 ] Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China [ 151 ] Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary [ 152 ] Vall dHebron Univ Hosp, VHIO, Oncogenet Lab, Barcelona, Spain [ 153 ] Catalan Inst Oncol, IDIBGI, Hereditary Canc Program, Genet Counseling Unit, Girona, Spain [ 154 ] Catalan Inst Oncol, IDIBELL Bellvitge Biomed Res Inst, Breast Canc & Syst Biol Unit, Barcelona, Spain [ 155 ] Univ Iceland, Fac Med, Landspitali Univ Hosp, Dept Pathol, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital University of Iceland [ 156 ] Univ Iceland, Fac Med, Biomed Ctr BMC, Reykjavik, Iceland [ 157 ] Ctr Hosp Univ Quebec, Div Med Genet, Quebec City, PQ, Canada [ 158 ] Univ Laval, Quebec City, PQ, Canada [ 159 ] Ctr Hosp Univ Quebec, Quebec City, PQ, Canada [ 160 ] IRCCS, IOV, Immunol & Mol Oncol Unit, Padua, Italy [ 161 ] Portuguese Oncol Inst, Dept Genet, Oporto, Portugal [ 162 ] Univ Porto, Biomed Sci Inst ICBAS, Rua Campo Alegre 823, P-4100 Oporto, Portugal [ 163 ] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA [ 164 ] McGill Univ, Program Canc Genet, Montreal, PQ, Canada [ 165 ] Masaryk Univ, Masaryk Mem Canc Inst, Brno, Czech Republic [ 166 ] Masaryk Univ, Fac Med, Brno, Czech Republic [ 167 ] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA [ 168 ] Med Univ Vienna, Ctr Comprehens Canc, Dept Obstet & Gynecol, Vienna, Austria [ 169 ] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Canc Epidemiol, Tampa, FL 33682 USA [ 170 ] NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, US NIH, Rockville, MD USA [ 171 ] Carmel Hosp, Dept Community Med & Epidemiol, Haifa, Israel [ 172 ] Technion Israel Inst Technol, Bruce Rappaport Fac Med, POB 9649, IL-31096 Haifa, Israel [ 173 ] Clalit Natl Israeli Canc Control Ctr, Haifa, Israel [ 174 ] NN Petrov Oncol Res Inst, St Petersburg, Russia [ 175 ] NorthShore Univ Hlth Syst, Ctr Med Genet, Evanston, IL USA [ 176 ] Peter MacCallum Canc Ctr, Div Canc Med, East Melbourne, Vic, Australia [ 177 ] Roswell Pk Canc Inst, Stat & Data Management Ctr, NRG Oncol, Buffalo, NY 14263 USA [ 178 ] Univ Hlth Network, Lab Med Program, Toronto, ON, Canada [ 179 ] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada [ 180 ] Vejle Hosp, Dept Clin Genet, Vejle, Denmark [ 181 ] Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark [ 182 ] Univ Pisa, Dept Lab Med, Sect Genet Oncol, Pisa, Italy [ 183 ] Univ Hosp Pisa, Pisa, Italy [ 184 ] Univ Malaya, Univ Malaya Med Ctr, Fac Med, Univ Malaya Canc Res Inst, Kuala Lumpur, Malaysia [ 185 ] Chaim Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, IL-52621 Tel Hashomer, Israel [ 186 ] Lund Univ, Dept Oncol, Lund, Sweden [ 187 ] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden [ 188 ] Univ Lund Hosp, Dept Clin Genet, S-22185 Lund, Sweden [ 189 ] Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden [ 190 ] Univ Chicago, Med Ctr, Ctr Clin Canc Genet & Global Hlth, Chicago, IL 60637 USA [ 191 ] Univ Calif Los Angeles, Sch Med, Johnsson Comprehens Canc Ctr, Div Canc Prevent & Control Res, Los Angeles, CA USA [ 192 ] Univ Calif Los Angeles, Sch Publ Hlth, Johnsson Comprehens Canc Ctr, Div Canc Prevent & Control Res, Los Angeles, CA USA [ 193 ] Univ Calif San Francisco, Dept Med & Genet, San Francisco, CA 94143 USA [ 194 ] Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA [ 195 ] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA [ 196 ] Peter MacCallum Canc Ctr, Familial Canc Ctr, Melbourne, Vic, Australia [ 197 ] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia [ 198 ] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Los Angeles, CA 90048 USA [ 199 ] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA [ 200 ] Dalhousie Univ, Dept Obstet Gynaecol & Pediat, Halifax, NS, Canada [ 201 ] Univ Western Australia, Ctr Genet Origins Hlth & Dis, Perth, WA 6009, Australia [ 202 ] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA [ 203 ] Harvard Univ, Sch Med, Boston, MA USA [ 204 ] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA [ 205 ] Harvard Univ, Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 665 Huntington Ave, Boston, MA 02115 USA [ 206 ] Univ Cambridge, Dept Publ Hlth & Primary Care, Clin Gerontol, Cambridge, England

Subjects
0301 basic medicine, Genes, BRCA2, Estrogen receptor, MODIFIERS, Gene Expression, Genome-wide association study, Cell Cycle Proteins, DISEASE, Breast cancer, Risk Factors, Brjóstakrabbamein, BRCA2 MUTATION CARRIERS, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], SUSCEPTIBILITY LOCUS, MAMMOGRAPHIC DENSITY, Regulation of gene expression, Genetics, Research Support, Non-U.S. Gov't, Estrogen Receptor alpha/genetics, Phenotype, 3. Good health, Gene Expression Regulation, Neoplastic, Medical genetics, Chromosomes, Human, Pair 6, Female, BONE-MINERAL DENSITY, NAF12, Protein Binding, EXPRESSION, medicine.medical_specialty, Locus (genetics), Breast Neoplasms, Estrògens, Biology, Breast Neoplasms/genetics, Polymorphism, Single Nucleotide, Article, Càncer de mama, 03 medical and health sciences, Research Support, N.I.H., Extramural, SDG 3 - Good Health and Well-being, REVEALS, medicine, Journal Article, cancer, Humans, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, METAANALYSIS, breast, Genetic Association Studies, Base Sequence, Estrogen Receptor alpha, Genetic Variation, Arfgengi, medicine.disease, Estrogen, 030104 developmental biology, breast cancer, BRCA1, BRCA2, Carrier Proteins, Estrogen receptor alpha, Research Support, U.S. Gov't, Non-P.H.S, Meta-Analysis
Abstract

To access publisher's full text version of this article click on the hyperlink at the bottom of the page We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each associated with different phenotype sets, including estrogen receptor (ER(+) or ER(-)) and human ERBB2 (HER2(+) or HER2(-)) tumor subtypes, mammographic density and tumor grade. The best candidate causal variants for ER(-) tumors lie in four separate enhancer elements, and their risk alleles reduce expression of ESR1, RMND1 and CCDC170, whereas the risk alleles of the strongest candidates for the remaining independent causal variant disrupt a silencer element and putatively increase ESR1 and RMND1 expression. National Institute for Health Research (NIHR) info:eu-repo/grantAgreement/EC/FP7/223175 Cancer Research UK C1287/A10118 C1287/A10710 C12292/A11174 C1281/A12014 C5047/A8384 C5047/A15007 C5047/A10692 C8197/A16565 US National Institutes of Health (NIH) CA128978 CA192393 CA116167 CA176785 US National Institutes of Health (NIH Specialized Program of Research Excellence (SPORE) in Breast Cancer) CA116201 Post-Cancer GWAS initiative 1U19 CA148537 1U19 CA148065 1U19 CA148112 Post-Cancer GWAS initiative (GAME-ON initiative) US Department of Defense W81XWH-10-1-0341 Canadian Institutes of Health Research (CIHR) Komen Foundation for the Cure Breast Cancer Research Foundation Ovarian Cancer Research Fund

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results