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Association analysis identifies 65 new breast cancer risk loci
- Source :
- Nature, 551(7678), 92-+. Nature Publishing Group, Nature, 551(7678), 92-94. Nature Publishing Group, Nature, 551(7678), 92, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Michailidou, K, Lindström, S, Dennis, J, Beesley, J, Hui, S, Kar, S, Lemaçon, A, Soucy, P, Glubb, D, Rostamianfar, A, Bolla, M K, Wang, Q, Tyrer, J, Dicks, E, Lee, A, Wang, Z, Allen, J, Keeman, R, Eilber, U, French, J D, Chen, X Q, Fachal, L, McCue, K, Reed, A E M C, Ghoussaini, M, Carroll, J S, Jiang, X, Finucane, H, Adams, M, Adank, M A, Ahsan, H, Aittomäki, K, Anton-Culver, H, Antonenkova, N N, Arndt, V, Aronson, K J, Arun, B, Auer, P L, Bacot, F, Barrdahl, M, Baynes, C, Beckmann, M W, Behrens, S, Benitez, J, Bermisheva, M, Bernstein, L, Blomqvist, C, Hooning, M J, Meijers-Heijboer, H, Waisfisz, Q, NBCS Collaborators, ABCTB Investigators & kConFab/AOCS Investigators 2017, ' Association analysis identifies 65 new breast cancer risk loci ', Nature, vol. 551, no. 7678, pp. 92-94 . https://doi.org/10.1038/nature24284, Nature, Michailidou, K, Lindström, S, Dennis, J, Beesley, J, Hui, S, Kar, S, Lemaçon, A, Soucy, P, Glubb, D, Rostamianfar, A, Bolla, M K, Wang, Q, Tyrer, J, Dicks, E, Lee, A, Wang, Z, Allen, J, Keeman, R, Eilber, U, French, J D, Qing Chen, X, Fachal, L, McCue, K, McCart Reed, A E, Ghoussaini, M, Carroll, J S, Jiang, X, Finucane, H, Adams, M, Adank, M A, Ahsan, H, Aittomäki, K, Anton-Culver, H, Antonenkova, N N, Arndt, V, Aronson, K J, Arun, B, Auer, P L, Bacot, F, Barrdahl, M, Baynes, C, Beckmann, M W, Behrens, S, Benitez, J, Bermisheva, M, Bernstein, L, Blomqvist, C, Bogdanova, N V, Bojesen, S E & Figueroa, J & Tomlinson, I 2017, ' Association analysis identifies 65 new breast cancer risk loci ', Nature, vol. 551, no. 7678, pp. 92–94 . https://doi.org/10.1038/nature24284, Nature, 551(7678), 92. Nature Publishing Group, Michailidou, K, Lindström, S, Dennis, J, Beesley, J, Hui, S, Kar, S, Lemaçon, A, Soucy, P, Glubb, D, Rostamianfar, A, Bolla, M K, Wang, Q, Tyrer, J, Dicks, E, Lee, A, Wang, Z, Allen, J, Keeman, R, Eilber, U, French, J D, Qing Chen, X, Fachal, L, McCue, K, McCart Reed, A E, Ghoussaini, M, Carroll, J S, Jiang, X, Finucane, H, Adams, M, Adank, M A, Ahsan, H, Aittomäki, K, Anton-Culver, H, Antonenkova, N N, Arndt, V, Aronson, K J, Arun, B, Auer, P L, Bacot, F, Barrdahl, M, Baynes, C, Beckmann, M W, Behrens, S, Benitez, J, Bermisheva, M, Bernstein, L, Blomqvist, C, Lophatananon, A, Muir, K, Scott, C & NBCS Collaborators 2017, ' Association analysis identifies 65 new breast cancer risk loci ', Nature, vol. 551, no. 7678, pp. 92-94 . https://doi.org/10.1038/nature24284
- Publication Year :
- 2017
-
Abstract
- Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P
- Subjects :
- 0301 basic medicine
Multifactorial Inheritance
Genome-wide association study
Regulatory Sequences, Nucleic Acid
skin and connective tissue diseases
Cancer genetics
Genetics
Multidisciplinary
medicine.diagnostic_test
3. Good health
Europe
annotation
Medical genetics
Female
Asian Continental Ancestry Group
medicine.medical_specialty
Asia
architecture
European Continental Ancestry Group
ABCTB Investigators
Locus (genetics)
Breast Neoplasms
Biology
Polymorphism, Single Nucleotide
Risk Assessment
Article
White People
NBCS Collaborators
03 medical and health sciences
Breast cancer
Asian People
SDG 3 - Good Health and Well-being
Genetic variation
ConFab/AOCS Investigators
expression
medicine
Genetic predisposition
Journal Article
Humans
Computer Simulation
Genetic Predisposition to Disease
biological pathways
Genetic association
Genetic testing
Genetic association study
Binding Sites
interaction networks
medicine.disease
comprehensive molecular portraits
mutations
susceptibility loci
030104 developmental biology
Genetic Loci
genome-wide association
protein
Transcription Factors
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 00280836
- Database :
- OpenAIRE
- Journal :
- Nature, 551(7678), 92-+. Nature Publishing Group, Nature, 551(7678), 92-94. Nature Publishing Group, Nature, 551(7678), 92, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Michailidou, K, Lindström, S, Dennis, J, Beesley, J, Hui, S, Kar, S, Lemaçon, A, Soucy, P, Glubb, D, Rostamianfar, A, Bolla, M K, Wang, Q, Tyrer, J, Dicks, E, Lee, A, Wang, Z, Allen, J, Keeman, R, Eilber, U, French, J D, Chen, X Q, Fachal, L, McCue, K, Reed, A E M C, Ghoussaini, M, Carroll, J S, Jiang, X, Finucane, H, Adams, M, Adank, M A, Ahsan, H, Aittomäki, K, Anton-Culver, H, Antonenkova, N N, Arndt, V, Aronson, K J, Arun, B, Auer, P L, Bacot, F, Barrdahl, M, Baynes, C, Beckmann, M W, Behrens, S, Benitez, J, Bermisheva, M, Bernstein, L, Blomqvist, C, Hooning, M J, Meijers-Heijboer, H, Waisfisz, Q, NBCS Collaborators, ABCTB Investigators & kConFab/AOCS Investigators 2017, ' Association analysis identifies 65 new breast cancer risk loci ', Nature, vol. 551, no. 7678, pp. 92-94 . https://doi.org/10.1038/nature24284, Nature, Michailidou, K, Lindström, S, Dennis, J, Beesley, J, Hui, S, Kar, S, Lemaçon, A, Soucy, P, Glubb, D, Rostamianfar, A, Bolla, M K, Wang, Q, Tyrer, J, Dicks, E, Lee, A, Wang, Z, Allen, J, Keeman, R, Eilber, U, French, J D, Qing Chen, X, Fachal, L, McCue, K, McCart Reed, A E, Ghoussaini, M, Carroll, J S, Jiang, X, Finucane, H, Adams, M, Adank, M A, Ahsan, H, Aittomäki, K, Anton-Culver, H, Antonenkova, N N, Arndt, V, Aronson, K J, Arun, B, Auer, P L, Bacot, F, Barrdahl, M, Baynes, C, Beckmann, M W, Behrens, S, Benitez, J, Bermisheva, M, Bernstein, L, Blomqvist, C, Bogdanova, N V, Bojesen, S E & Figueroa, J & Tomlinson, I 2017, ' Association analysis identifies 65 new breast cancer risk loci ', Nature, vol. 551, no. 7678, pp. 92–94 . https://doi.org/10.1038/nature24284, Nature, 551(7678), 92. Nature Publishing Group, Michailidou, K, Lindström, S, Dennis, J, Beesley, J, Hui, S, Kar, S, Lemaçon, A, Soucy, P, Glubb, D, Rostamianfar, A, Bolla, M K, Wang, Q, Tyrer, J, Dicks, E, Lee, A, Wang, Z, Allen, J, Keeman, R, Eilber, U, French, J D, Qing Chen, X, Fachal, L, McCue, K, McCart Reed, A E, Ghoussaini, M, Carroll, J S, Jiang, X, Finucane, H, Adams, M, Adank, M A, Ahsan, H, Aittomäki, K, Anton-Culver, H, Antonenkova, N N, Arndt, V, Aronson, K J, Arun, B, Auer, P L, Bacot, F, Barrdahl, M, Baynes, C, Beckmann, M W, Behrens, S, Benitez, J, Bermisheva, M, Bernstein, L, Blomqvist, C, Lophatananon, A, Muir, K, Scott, C & NBCS Collaborators 2017, ' Association analysis identifies 65 new breast cancer risk loci ', Nature, vol. 551, no. 7678, pp. 92-94 . https://doi.org/10.1038/nature24284
- Accession number :
- edsair.doi.dedup.....02ae4dc4b3b083725f91978a6ca648ed
- Full Text :
- https://doi.org/10.1038/nature24284