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202. Eosinophilic and Noneosinophilic Asthma An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort

Author

Heaney, Liam G. de Llano, Luis Perez Al-Ahmad, Mona Backer, Vibeke Busby, John Canonica, Giorgio Walter Christoff, George C. Cosio, Borja G. FitzGerald, J. Mark Heffler, Enrico Iwanaga, Takashi Jackson, David J. Menzies-Gow, Andrew N. Papadopoulos, Nikolaos G. Papaioannou, I, Andriana and Pfeffer, Paul E. Popov, Todor A. Porsbjerg, Celeste M. Rhee, Chin Kook Sadatsafavi, Mohsen Tohda, Yuji Wang, Eileen and Wechsler, Michael E. Alacqua, Marianna Altraja, Alan and Bjermer, Leif Bjornsdottir, Unnur S. Bourdin, Arnaud and Brusselle, Guy G. Buhl, Roland Costello, Richard W. Hew, Mark Koh, Mariko Siyue Lehmann, Sverre Lehtimaki, Lauri and Peters, Matthew Taille, Camille Taube, Christian Tran, Trung N. Zangrilli, James Bulathsinhala, Lakmini Carter, Victoria A. Chaudhry, Isha Eleangovan, Neva Hosseini, Naeimeh and Kerkhof, Marjan Murray, Ruth B. Price, Chris A. Price, David B.

Abstract

BACKGROUND: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts. RESEARCH QUESTION: What is the prevalence of eosinophilic and noneosinophilic phenotypes in the population with severe asthma, and can these phenotypes be differentiated by clinical and biomarker variables? STUDY DESIGN AND METHODS: This was an historical registry study. Adult patients with severe asthma and available blood eosinophil count (BEC) from 11 countries enrolled in the International Severe Asthma Registry (January 1, 2015-September 30, 2019) were categorized according to likelihood of eosinophilic phenotype using a predefined gradient eosinophilic algorithm based on highest BEC, long-term oral corticosteroid use, elevated fractional exhaled nitric oxide, nasal polyps, and adult-onset asthma. Demographic and clinical characteristics were defined at baseline (ie, 1 year before or closest to date of BEC). RESULTS: One thousand seven hundred sixteen patients with prospective data were included; 83.8% were identified as most likely (grade 3), 8.3% were identified as likely (grade 2), and 6.3% identified as least likely (grade 1) to have an eosinophilic phenotype, and 1.6% of patients showed a noneosinophilic phenotype (grade 0). Eosinophilic phenotype patients (ie, grades 2 or 3) showed later asthma onset (29.1 years vs 6.7 years; P

Published
2021

203. COVID-19 in Severe Asthma Network in Italy (SANI) patients: Clinical features, impact of comorbidities and treatments

Author

Heffler, Enrico, Detoraki, Aikaterini, Contoli, Marco, Papi, Alberto, Paoletti, Giovanni, Malipiero, Giacomo, Brussino, Luisa, Crimi, Claudia, Morrone, Daniela, Padovani, Marianna, Guida, Giuseppe, Gerli, Alberto Giovanni, Centanni, Stefano, Senna, Gianenrico, Paggiaro, Pierluigi, Blasi, Francesco, Canonica, Giorgio Walter, SANI Working Group, Bonavia, M, Bucca, C, Caiaffa, Mf, Calabrese, C, Camiciottoli, G, Caruso, C, Conte, Me, Corsico, Ag, Cosmi, L, Costantino, Mt, Crimi, N, D’Alò, S, D’Amato, M, Del Giacco, S, Farsi, A, Favero, E, Foschino, Bmp, Guarnieri, G, Lo Cicero, S, Lombardi, C, Macchia, L, Mazza, F, Menzella, F, Milanese, M, Montuschi, P, Montagni, M, Nucera, E, Parente, R, Passalacqua, G, Patella, V, Pelaia, G, Pini, L, Puggioni, F, Ricciardi, L, Ricciardolo, Flm, Richeldi, L, Ridolo, E, Rolla, G, Santus, P, Scichilone, N, Solidoro, P, Spadaro, G, Vianello, A, Viviano, V, Yacoub, Mr, Zappa, Mc, Heffler E., Detoraki A., Contoli M., Papi A., Paoletti G., Malipiero G., Brussino L., Crimi C., Morrone D., Padovani M., Guida G., Gerli A.G., Centanni S., Senna G., Paggiaro P., Blasi F., Canonica G.W., Bonavia M., Bucca C., Caiaffa M.F., Calabrese C., Camiciottoli G., Caruso C., Conte M.E., Corsico A.G., Cosmi L., Costantino M.T., Crimi N., D'Alo S., D'Amato M., Del Giacco S., Farsi A., Favero E., Foschino B.M.P., Guarnieri G., Cicero S.L., Lombardi C., Macchia L., Mazza F., Menzella F., Milanese M., Montuschi P., Montagni M., Nucera E., Parente R., Passalacqua G., Patella V., Pelaia G., Pini L., Puggioni F., Ricciardi L., Ricciardolo F.L.M., Richeldi L., Ridolo E., Rolla G., Santus P., Scichilone N., Solidoro P., Spadaro G., Vianello A., Viviano V., Yacoub M.R., and Zappa M.C.

Subjects
severe asthma, medicine.medical_specialty, 2019-20 coronavirus outbreak, COVID-19, Severe Asthma Network in Italy, inflammation, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Severe asthma, Population, Immunology, MEDLINE, Omalizumab, Settore MED/10 - Malattie Dell'Apparato Respiratorio, NO, Internal medicine, Diabetes mellitus, Severity of illness, medicine, Immunology and Allergy, Risk factor, Letters to the Editor, education, Letter to the Editor, Asthma, education.field_of_study, business.industry, Incidence (epidemiology), Mortality rate, COVID-19, medicine.disease, Comorbidity, Severe Asthma Network in Italy, inflammation, Cohort, business, Mepolizumab, medicine.drug
Abstract

To the Editor Since the end of February 2020 Italy, first non- Asian Country, has reported an ever increasing number of COronaVIrus Disease 19 (COVID-19) patients, which has reached over 200,000 confirmed Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infected subjects and resulted in more than 34000 deaths (data updated to June 19th, 20201).Patients with asthma are potentially more severely affected by by SARS-CoV-2 infection 2 and it is well established that respiratory viral infections are associated with severe adverse outcomes in patients with asthma, including increased risk of asthma exacerbation episodes 3. Nonetheless, according to the epidemiological studies published so far, chronic pulmonary diseases are not amongst the most common clinical conditions in COVID-19 patients4About 5-10% of entire asthma population, are severe asthmatics5 and one would expect increased vulnerability to SARS-CoV-2 infection, but no data is so fare available ti confirm this hypothesis.We investigated the incidence of COVID-19, describing its clinical course, in the population of the Severe Asthma Network in Italy (SANI), one of the largest registry for severe asthma worldwide6, and in an additional Center (Azienda Ospedaliero Univeristaria di Ferrara, Ferrara, Italy). All centers, have been contacted and inquired to report confirmed (i.e. patients with positive test result for the virus SARS-CoV-2 from analysis of nasopharyngeal or oropharyngeal swab specimens) or highly suspect cases of COVID-19 (i.e. patients with symptoms, laboratory findings and lung imaging typical of COVID-19 but without access to nasopharyngeal or oropharyngeal swab specimens because of clinical contingencies/emergency) among their cohorts of severe asthma. Demographic and clinical data of the entire cohort of severe asthmatics enrolled in the study and all reported cases of confirmed or suspect cases of COVID-19, have been obtained from the registry platform and collected from the additional Center. Additional data about COVID-19 symptoms, treatment and clinical course have been collected for all cases reported.Ethical issues and statistical analysis are reported in the online supplementary material.Twenty-six (1.73%) out of 1504 severe asthmatics had confirmed (11 out of 26) or highly suspect COVID-19 (15 out 26); eighteen (69.2%) were females and mean age was 56.2 ± 10 years. The geographical distribution of COVID-19 cases is presented in Figure 1.Nine (34.6%) infected patients experienced worsening of asthma during the COVID-19 symptomatic period; four of them needed a short course of oral corticosteroids for controlling asthma exacerbation symptoms.The most frequent COVID-19 symptoms reported were fever (100% of patients), malaise (84.6%), cough (80.8%), dyspnea (80.8%), headache (42.3%) and loss of smell (42.3%). Four patients (15.3%) have been hospitalized, one of which in intensive care unit; among hospitalized patients, two (7.7%) died for COVID-19 interstitial pneumonia. No deaths have been reported among the non-hospitalized patients.Severe asthmatics affected by COVID-19, had a significantly higher prevalence of non-insulin-dependent diabetes mellitus (NIDDM) compared to non-infected severe asthma patients (15.4% vs 3.8%, p=0.002; odds ratio: 4.7). No difference was found in other comorbidities (including rhinitis, chronic rhinosinusitis with or without nasal polyps, bronchiectasis, obesity, gastroesophageal reflux, arterial hypertension, cardiovascular diseases).Twenty-one patients with COVID-19 were on biological treatments: 15 (71%) were on anti-IL-5 or anti-IL5R agents (Mepolizumab n= 13; Benralizumab n=2 - counting for the 2.9% of all severe asthmatics treated with anti-IL5 in our study population) and 6 (29%) were on anti IgE (Omalizumab - 1.3% of all severe asthmatics treated with omalizumab in our study population).Table I summarizes demographic and clinical characteristics of the 26 COVID-19 patients.In conclusion, in our large cohort of severe asthmatics, COVID-19 was infrequent, not supporting the concept of asthma as a particularly susceptible condition to SARS-COV2 infection 2. This is in line with the first published large epidemiological data on COVID-19 patients, in which asthma is under-reported as comorbidity4. The COVID-19 related mortality rate in our cohort of patients was 7.7%, lower than the COVID-19 mortality rate in the general population (14.5% in Italy 1). These findings suggest that severe asthmatics are not at high risk of the SARS-CoV-2 infection and of severe forms of COVID-19. There are potentially different reasons for this. Self-containment is the first, because of the awareness of virus infections acting as a trigger for exacerbations, and therefore they could have acted with greater caution, scrupulously respecting social distancing, lockdown and hygiene rules of prevention, and being more careful in regularly taking asthma medications.Another possible explanation stands in the intrinsic features of type-2 inflammation, that characterizes a great proportion of severe asthmatics. Respiratory allergies and controlled allergen exposures are associated with significant reduction in angiotensin-converting enzyme 2 (ACE2) expression 7, the cellular receptor for SARS-CoV-2. Interestingly, ACE2 and Transmembrane Serine Protease 2 (TMPRSS2) (another protein mediating SARS-CoV-2 cell entry) have been found highly expressed in asthmatics with concomitant NIDDM8, the only comorbidity that was more frequent reported in our COVID-19 severe asthmatics.The third possible explanation refers to the possibility that inhaled corticosteroids (ICS) might prevent or mitigate the development of Coronaviruses infections. By definition, patients with severe asthma are treated with high doses of ICS 5 and this may have had a protective effect for SARS-CoV-2 infection.Noteworthy, among the patients of our case-series of severe asthmatics with COVID-19, the proportion of those treated anti-IL5 biologics was higher (71%) compared to the number of patients treated with anti-IgE (29%). Although the number of cases is too small to draw any conclusion, it is tempting to speculate that different biological treatments can have specific and different impact on antiviral immune response. In addition we may speculate of the consequence of blood eosinophils reduction: eosinopenia has been reported in 52-90% of COVID-19 patients worldwide and it has been suggested as a risk factor for more severe COVID-19 9.In conclusion, in our large cohort of severe asthmatics only a small minority experienced symptoms consistent with COVID-19, and these patients had peculiar clinical features including high prevalence of NIDDM as comorbidity. Further real-life registry-based studies are needed to confirm our findings and to extend the evidence that severe asthmatics are at low risk of developing COVID-19.

Published
2021

204. Digital transformation of health and care in airway diseases from research to practice

Author

Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T.T., Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga M., Melén, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhân, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagaña, Xavier, D. Bateman, Eric, Bédard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean François, Fuentes Perez, José M., Gemicioğlu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, René Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michaël, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Björn, Novellino, Ettore, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Schöll, Isabella, Panzner, Peter, Park, Hae Sim, Passalacqua, Gianni, Pépin, Jean Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Söderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schünemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, François, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stéphane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, Zidarn, Mihaela, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
ARIA, rhinitis, CARAT, MASK, Immunology, Immunology and Allergy, asthma, digital transformation of health and care
Abstract

Funding: MA reports personal fees from POCI-01-0145-FEDER-029130 mINSPIRERS—mHealth to measure and improve adherence to medication in chronic obstructive respiratory diseases—generalization and evaluation of gamification, peer support and advanced image processing technologies from ERDF (European Regional Development Fund) funded by the COMPETE2020 and by National Funds through FCT (Fundação para a Ciência e a Tecnologia)… Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed. publishersversion published

Published
2021

205. ARIA digital anamorphosis: Digital transformation of health and care in airway diseases from research to practice

Author

Bousquet, Jean Anto, Josep M. Bachert, Claus Haahtela, Tari and Zuberbier, Torsten Czarlewski, Wienczyslawa Bedbrook, Anna and Bosnic-Anticevich, Sinthia Walter Canonica, G. Cardona, Victoria Costa, Elisio Cruz, Alvaro A. Erhola, Marina and Fokkens, Wytske J. Fonseca, Joao A. Illario, Maddalena and Ivancevich, Juan-Carlos Jutel, Marek Klimek, Ludger Kuna, Piotr Kvedariene, Violeta Le, L. T. T. Larenas-Linnemann, Desiree E. Laune, Daniel Lourenco, Olga M. Melen, Erik and Mullol, Joaquim Niedoszytko, Marek Odemyr, Mikaela Okamoto, Yoshitaka Papadopoulos, Nikos G. Patella, Vincenzo Pfaar, Oliver Pham-Thi, Nhan Rolland, Christine Samolinski, Boleslaw Sheikh, Aziz Sofiev, Mikhail Suppli Ulrik, Charlotte Todo-Bom, Ana Tomazic, Peter-Valentin and Toppila-Salmi, Sanna Tsiligianni, Ioanna Valiulis, Arunas and Valovirta, Erkka Ventura, Maria-Teresa Walker, Samantha and Williams, Sian Yorgancioglu, Arzu Agache, Ioana Akdis, Cezmi A. Almeida, Rute Ansotegui, Ignacio J. Annesi-Maesano, Isabella Arnavielhe, Sylvie Basagana, Xavier D. Bateman, Eric Bedard, Annabelle Bedolla-Barajas, Martin Becker, Sven and Bennoor, Kazi S. Benveniste, Samuel Bergmann, Karl C. and Bewick, Michael Bialek, Slawomir E. Billo, Nils and Bindslev-Jensen, Carsten Bjermer, Leif Blain, Hubert Bonini, Matteo Bonniaud, Philippe Bosse, Isabelle Bouchard, Jacques and Boulet, Louis-Philippe Bourret, Rodolphe Boussery, Koen and Braido, Fluvio Briedis, Vitalis Briggs, Andrew Brightling, Christopher E. Brozek, Jan Brusselle, Guy Brussino, Luisa and Buhl, Roland Buonaiuto, Roland Calderon, Moises A. and Camargos, Paulo Camuzat, Thierry Caraballo, Luis Carriazo, Ana-Maria Carr, Warner Cartier, Christine Casale, Thomas and Cecchi, Lorenzo Cepeda Sarabia, Alfonso M. H. Chavannes, Niels and Chkhartishvili, Ekaterine Chu, Derek K. Cingi, Cemal and Correia de Sousa, Jaime Costa, David J. Courbis, Anne-Lise and Custovic, Adnan Cvetkosvki, Biljana D'Amato, Gennaro da Silva, Jane Dantas, Carina Dokic, Dejan Dauvilliers, Yves and De Feo, Giulia De Vries, Govert Devillier, Philippe Di Capua, Stefania Dray, Gerard Dubakiene, Ruta Durham, Stephen R. Dykewicz, Marc Ebisawa, Motohiro Gaga, Mina El-Gamal, Yehia Heffler, Enrico Emuzyte, Regina Farrell, John and Fauquert, Jean-Luc Fiocchi, Alessandro Fink-Wagner, Antje and Fontaine, Jean-Francois Fuentes Perez, Jose M. Gemicioglu, Bilun and Gamkrelidze, Amiran Garcia-Aymerich, Judith Gevaert, Philippe Gomez, Rene Maximiliano Gonzalez Diaz, Sandra and Gotua, Maia Guldemond, Nick A. Guzman, Maria-Antonieta and Hajjam, Jawad Huerta Villalobos, Yunuen R. Humbert, Marc and Iaccarino, Guido Ierodiakonou, Despo Iinuma, Tomohisa and Jassem, Ewa Joos, Guy Jung, Ki-Suck Kaidashev, Igor and Kalayci, Omer Kardas, Przemyslaw Keil, Thomas Khaitov, Musa and Khaltaev, Nikolai Kleine-Tebbe, Jorg Kouznetsov, Rostislav and Kowalski, Marek L. Kritikos, Vicky Kull, Inger La Grutta, Stefania Leonardini, Lisa Ljungberg, Henrik and Lieberman, Philip Lipworth, Brian Lodrup Carlsen, Karin C. and Lopes-Pereira, Catarina Loureiro, Claudia C. Louis, Renaud and Mair, Alpana Mahboub, Bassam Makris, Michael Malva, Joao and Manning, Patrick Marshall, Gailen D. Masjedi, Mohamed R. and Maspero, Jorge F. Carreiro-Martins, Pedro Makela, Mika and Mathieu-Dupas, Eve Maurer, Marcus De Manuel Keenoy, Esteban and Melo-Gomes, Elisabete Meltzer, Eli O. Menditto, Enrica and Mercier, Jacques Micheli, Yann Miculinic, Neven Mihaltan, Florin Milenkovic, Branislava Mitsias, Dimitirios I. Moda, Giuliana Mogica-Martinez, Maria-Dolores Mohammad, Yousser and Montefort, Steve Monti, Ricardo Morais-Almeida, Mario and Mosges, Ralph Munter, Lars Muraro, Antonella Murray, Ruth and Naclerio, Robert Napoli, Luigi Namazova-Baranova, Leyla and Neffen, Hugo Nekam, Kristoff Neou, Angelo Nordlund, Bjorn and Novellino, Ettore Nyembue, Dieudonne O'Hehir, Robyn and Ohta, Ken Okubo, Kimi Onorato, Gabrielle L. Orlando, Valentina Ouedraogo, Solange Palamarchuk, Julia Pali-Scholl, Isabella Panzner, Peter Park, Hae-Sim Passalacqua, Gianni and Pepin, Jean-Louis Paulino, Ema Pawankar, Ruby Phillips, Jim Picard, Robert Pinnock, Hilary Plavec, Davor Popov, Todor A. Portejoie, Fabienne Price, David Prokopakis, Emmanuel P. Psarros, Fotis Pugin, Benoit Puggioni, Francesca and Quinones-Delgado, Pablo Raciborski, Filip and Rajabian-Soderlund, Rojin Regateiro, Frederico S. Reitsma, Sietze Rivero-Yeverino, Daniela Roberts, Graham Roche, Nicolas Rodriguez-Zagal, Erendira Rolland, Christine and Roller-Wirnsberger, Regina E. Rosario, Nelson Romano, Antonino and Rottem, Menachem Ryan, Dermot Salimaki, Johanna and Sanchez-Borges, Mario M. Sastre, Joaquin Scadding, Glenis K. and Scheire, Sophie Schmid-Grendelmeier, Peter Schunemann, Holger J. and Sarquis Serpa, Faradiba Shamji, Mohamed Sisul, Juan-Carlos and Sofiev, Mikhail Sole, Dirceu Somekh, David Sooronbaev, Talant Sova, Milan Spertini Spranger, Otto Stellato, Cristiana Stelmach, Rafael Thibaudon, Michel To, Teresa and Toumi, Mondher Usmani, Omar Valero, Antonio A. Valenta, Rudolph Valentin-Rostan, Marylin Pereira, Marilyn Urrutia and van der Kleij, Rianne Van Eerd, Michiel Vandenplas, Olivier and Vasankari, Tuula Vaz Carneiro, Antonio Vezzani, Giorgio and Viart, Frederic Viegi, Giovanni Wallace, Dana Wagenmann, Martin Wang, De Yun Waserman, Susan Wickman, Magnus and Williams, Dennis M. Wong, Gary Wroczynski, Piotr Yiallouros, Panayiotis K. Yusuf, Osman M. Zar, Heather J. Zeng, Stephane and Zernotti, Mario E. Zhang, Luo Shan Zhong, Nan Zidarn, Mihaela

Abstract

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.

Published
2021

206. Das europäische Curriculum für die Zusatzbezeichnung Allergologie. Ein Positionspapier des Ärzteverbandes Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B und der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C in Kooperation mit der Europäischen Akademie für Allergologie und klinische Immunologie (EAACI)D und der Sektion Allergologie der Europäischen Union Medizinischer Spezialisten (UEMS)E

Author

Muelleneisen, Norbert, Klimek, Ludger, Worm, Margitta, Merk, Hans, Rabe, Uta, Biedermann, Tilo, Jung, Kirsten, Schlenter, Wolfgang, Ring, Johannes, Chaker, Adam, Wehrmann, Wolfgang, Becker, Sven, Bergmann, Karl-Christian A., Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolf, Fuchs, Thomas, Matricardi, Paolo, Hamelmann, Eckard, Jakob, Thilo, Werfel, Thomas, Wagenmann, Martin, Taube, Christian, Gerstlauer, Michael, Vogelberg, Christian, Van Wijk, Roy Gerth, Eguiluz-Gracia, Ibon, Gayraud, Jacques, Gutermuth, Jan, Heffler, Enrico, Popov, Todor A., Schmid-Grendelmeier, Peter, Tomazic, Peter V., Tsilochristou, Olympia, Del Giacco, Stefano, Zuberbier, Torsten, and Jutel, Marek

Subjects
Political science, Immunology and Allergy, Humanities
Abstract

Hintergrund: Die Vision der europaischen allergologischen Gesellschaften ist es, die Ausbildung zum Allergologen in Europa zu vereinheitlichen und prinzipiell den Facharzt fur Allergologie zu fordern und zu fordern. In den meisten europaischen Landern gibt es bereits den Facharzt fur Allergologie. In Deutschland gibt es leider nur eine Zusatzbezeichnung Allergologie. Methoden: Um nun auch fur Lander mit lediglich einer Zusatzbezeichnung fur Allergologie eine Vorlage zu erstellen, hat die European Academy of Allergy and Clinical Immunology (EAACI) in Kooperation mit der Union Europeenne des Medecins Specialistes (UEMS) ein Curriculum fur eine Zusatzbezeichnung erstellt und veroffentlicht. Im Folgenden wird dieses europaische Positionspapier in deutscher Ubersetzung und in Anpassung an die deutschen Verhaltnisse vorgestellt. Die beteiligten Autoren reprasentieren die deutschen und die europaischen, allergologischen Fachgesellschaften. Ergebnisse: Dieses Curriculum soll den Mindeststandard der Ausbildung zum Allergologen in Deutschland beschreiben und die theoretischen Kenntnisse, Fahigkeiten, Kompetenzen sowie die Anforderungen an Ausbilder und Ausbildungsinstitutionen benennen. Schlussfolgerung: Ohne einen vollen Facharzt fur Allergologie mussen die Subspezialisten in der Allergologie zwingend mit anderen Fachgruppen kooperieren, Kompetenzen teilen und eine gemeinsame Sprache entwickeln. Die Harmonisierung der Ausbildung ist der einzige Weg, um dies zu erreichen. Fur die Zusatzbezeichnung 18 Monate Weiterbildung und fur den Facharzt funf Jahre Weiterbildung: das ist der europaische Weg. Die Deutschen Allergologen verlieren sonst den Anschluss an die europaische Entwicklung und senken die Qualitat der Ausbildung zum Allergologen gefahrlich ab.

Published
2021

207. Type 2-High Severe Asthma with and without Bronchiectasis: A Prospective Observational Multicentre Study

Author

Crimi,Claudia, Campisi,Raffaele, Nolasco,Santi, Ferri,Sebastian, Cacopardo,Giulia, Impellizzeri,Pietro, Pistorio,Maria Provvidenza, Fagone,Evelina, Pelaia,Corrado, Heffler,Enrico, Crimi,Nunzio, Crimi,Claudia, Campisi,Raffaele, Nolasco,Santi, Ferri,Sebastian, Cacopardo,Giulia, Impellizzeri,Pietro, Pistorio,Maria Provvidenza, Fagone,Evelina, Pelaia,Corrado, Heffler,Enrico, and Crimi,Nunzio

Abstract

Claudia Crimi,1 Raffaele Campisi,1 Santi Nolasco,2 Sebastian Ferri,3,4 Giulia Cacopardo,5 Pietro Impellizzeri,2 Maria Provvidenza Pistorio,2 Evelina Fagone,2 Corrado Pelaia,6 Enrico Heffler,3,4 Nunzio Crimi1,2 1Respiratory Medicine Unit, A.O.U. Policlinico “G. Rodolico - San Marco”, Catania, Italy; 2Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy; 3Personalized Medicine, Asthma and Allergy - IRCCS Humanitas Research Hospital, Rozzano, Italy; 4Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy; 5Respiratory Intensive Care Unit, ARNAS Civico General Hospital, Palermo, Italy; 6Department of Medical and Surgical Sciences, University “Magna Graecia”, Catanzaro, ItalyCorrespondence: Claudia CrimiRespiratory Medicine Unit, A.O.U. Policlinico “G. Rodolico - San Marco”, Catania, ItalyEmail dott.claudiacrimi@gmail.comIntroduction: Type 2-high severe asthma (T2-SA) is often associated with several comorbidities. To this extent, the coexistence of T2-SA and bronchiectasis (BE) is considered an emerging phenotype.Methods: We performed a prospective observational multicentre study, including T2-SA patients. Chest HRCT confirmed the presence of BE. Data on exacerbations, pulmonary function, Asthma Control Test (ACT), chronic mucus hypersecretion (CMH), chronic rhinosinusitis (CRS), oral corticosteroid (OCS) dosage, eosinophils in peripheral blood and FeNO were recorded. The Bhalla score was used for radiological assessment of T2-SA+BE patients and the Bronchiectasis Severity Index (BSI) was calculated.Results: A total of 113 patients (mean age 55 ± 11 years, 59.3% female) were enrolled. Co-presence of BE was confirmed in 50/113 (44.2%) patients who identified the T2-SA+BE group. CRS and CRSwNP were more prevalent in T2-SA+BE vs T2-SA [respectively, 42/50 (84%) vs 37/63 (58.7%), p = 0.004 and 27/50 (54%) vs 27/63 (42.9%), p = 0.0165]. Furthermore, T2-SA+BE patients reported more CMH compared to T2

Published
2021

208. Allergen immunotherapy: The growing role of observational and randomized trial Real-World Evidence

Author

Paoletti, Giovanni, Di Bona, Danilo, Chu, Derek K., Firinu, Davide, Heffler, Enrico, Agache, Ioana, Jutel, Marek, Klimek, Ludger, Pfaar, Oliver, Moesges, Ralph, DunnGalvin, Audrey, Genuneit, Jon, Hoffmann, Hans Jurgen, Canonica, Giorgio Walter, Paoletti, Giovanni, Di Bona, Danilo, Chu, Derek K., Firinu, Davide, Heffler, Enrico, Agache, Ioana, Jutel, Marek, Klimek, Ludger, Pfaar, Oliver, Moesges, Ralph, DunnGalvin, Audrey, Genuneit, Jon, Hoffmann, Hans Jurgen, and Canonica, Giorgio Walter

Abstract

Background Although there is a considerable body of knowledge about allergen immunotherapy (AIT), there is a lack of data on the reliability of real-world evidence (RWE) in AIT, and consequently, a lack of information on how AIT effectively works in real life. Methods To address the current unmet need for an appraisal of the quality of RWE in AIT, the European Academy of Allergy and Clinical Immunology Methodology Committee recently initiated a systematic review of observational studies of AIT, which will use the RELEVANT tool and the Grading of Recommendations Assessment, Development and Evaluation approach (GRADE) to rate the quality of the evidence base as a whole. The next step will be to develop a broadly applicable, pragmatic real-world database using systematic data collection. Based on the current RWE base, and perspectives and recommendations of authorities and scientific societies, a hierarchy of RWE in AIT is proposed, which places pragmatic trials and registry data at the positions of highest level of evidence. Key Results There is a need to establish more AIT registries that collect data in a cohesive way, using standardized protocols. Conclusions This will provide an essential source of real-world data that can be easily shared, promoting evidence-based research and quality improvement in study design and clinical decision-making.

Published
2021

209. ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Author

Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, Zidarn, Mihaela, Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, and Zidarn, Mihaela

Abstract

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.

Published
2021
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210. Eosinophilic and Noneosinophilic Asthma:An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort

Author

Heaney, Liam G., Perez de Llano, Luis, Al-Ahmad, Mona, Backer, Vibeke, Busby, John, Canonica, Giorgio Walter, Christoff, George C., Cosio, Borja G., FitzGerald, J. Mark, Heffler, Enrico, Iwanaga, Takashi, Jackson, David J., Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Alacqua, Marianna, Altraja, Alan, Bjermer, Leif, Björnsdóttir, Unnur S., Bourdin, Arnaud, Brusselle, Guy G., Buhl, Roland, Costello, Richard W., Hew, Mark, Koh, Mariko Siyue, Lehmann, Sverre, Lehtimäki, Lauri, Peters, Matthew, Taillé, Camille, Taube, Christian, Tran, Trung N., Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Kerkhof, Marjan, Murray, Ruth B., Price, Chris A., Price, David B., Heaney, Liam G., Perez de Llano, Luis, Al-Ahmad, Mona, Backer, Vibeke, Busby, John, Canonica, Giorgio Walter, Christoff, George C., Cosio, Borja G., FitzGerald, J. Mark, Heffler, Enrico, Iwanaga, Takashi, Jackson, David J., Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Alacqua, Marianna, Altraja, Alan, Bjermer, Leif, Björnsdóttir, Unnur S., Bourdin, Arnaud, Brusselle, Guy G., Buhl, Roland, Costello, Richard W., Hew, Mark, Koh, Mariko Siyue, Lehmann, Sverre, Lehtimäki, Lauri, Peters, Matthew, Taillé, Camille, Taube, Christian, Tran, Trung N., Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Kerkhof, Marjan, Murray, Ruth B., Price, Chris A., and Price, David B.

Abstract

Background: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts. Research Question: What is the prevalence of eosinophilic and noneosinophilic phenotypes in the population with severe asthma, and can these phenotypes be differentiated by clinical and biomarker variables? Study Design and Methods: This was an historical registry study. Adult patients with severe asthma and available blood eosinophil count (BEC) from 11 countries enrolled in the International Severe Asthma Registry (January 1, 2015-September 30, 2019) were categorized according to likelihood of eosinophilic phenotype using a predefined gradient eosinophilic algorithm based on highest BEC, long-term oral corticosteroid use, elevated fractional exhaled nitric oxide, nasal polyps, and adult-onset asthma. Demographic and clinical characteristics were defined at baseline (ie, 1 year before or closest to date of BEC). Results: One thousand seven hundred sixteen patients with prospective data were included; 83.8% were identified as most likely (grade 3), 8.3% were identified as likely (grade 2), and 6.3% identified as least likely (grade 1) to have an eosinophilic phenotype, and 1.6% of patients showed a noneosinophilic phenotype (grade 0). Eosinophilic phenotype patients (ie, grades 2 or 3) showed later asthma onset (29.1 years vs 6.7 years; P < .001) and worse lung function (postbronchodilator % predicted FEV1, 76.1% vs 89.3%; P = .027) than those with a noneosinophilic phenotype. Patients with noneosinophilic phenotypes were more likely to be women (81.5% vs 62.9%; P = .047), to have eczema (20.8% vs 8.5%; P = .003), and to use anti-IgE (32.1% vs 13.4%; P = .004) and leukotriene receptor antagonists (50.0% vs 28.0%; P = .011) add-on therapy. Interpretation: According to this multicomponent, consensus-driven, and evidence-based eosinophil gradient algorithm (using variables readily accessi

Published
2021

211. Real-life survey on severe asthma patients during COVID-19 lockdown in Italy

Author

Caruso, Cristiano, Colantuono, Stefania, Urbani, Sara, Heffler, Enrico, Canonica, Giorgio Walter, Andriollo, Gloria, Di Michele, Loreta, Scarlata, Simone, Zennaro, Danila, Rigon, Amelia, Vadacca, Marta, Moroni, Rossana, Nucera, Eleonora, Gasbarrini, Antonio, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Caruso, Cristiano, Colantuono, Stefania, Urbani, Sara, Heffler, Enrico, Canonica, Giorgio Walter, Andriollo, Gloria, Di Michele, Loreta, Scarlata, Simone, Zennaro, Danila, Rigon, Amelia, Vadacca, Marta, Moroni, Rossana, Nucera, Eleonora, Gasbarrini, Antonio, Nucera, Eleonora (ORCID:0000-0002-0565-7680), and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Introduction: The SARS-CoV-2 pandemic has deeply revolutionized our lives and consequently the management of patients, specifically ones with severe asthma.Objective: A survey was conducted to evaluate the effects on adherence, exacerbations and quality of life in patients with severe asthma during the COVID-19 pandemic period.Methods: 100 severe asthma patients, who accepted to participate to the survey, were asked to respond to different questionnaires in order to assess asthma symptoms (Asthma Control Test - ACT, and Asthma Control Quality - ACQ) and rino-sinusal ones (Sino-nasal outcome test - SNOT-22).Results: 31 out of 100 patients reported worsening of respiratory symptoms requiring a step-up in therapy dosage or frequency during the observational period; however, exacerbation rate was very low. Only 17 (17%) of the 100 participants experienced a severe asthma exacerbation. Moreover, there was no confirmed diagnosis of COVID-19 in this population.Conclusion: Patients with severe asthma did not show higher rates of exacerbations during the pandemic outbreak as well as no increased risk of contracting COVID-19 infection or developing the disease. Self-administration of biological drugs could be useful to maintain high rates of adherence to therapy, and, at the same time, to decrease the risk of exacerbations or Intensive Care Unit (ICU) room access.

Published
2021

212. Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies.

Author

Jacobsen, Elizabeth A, Jackson, David J, Heffler, Enrico, Mathur, Sameer K, Bredenoord, Albert Jan, Pavord, Ian ID, Akuthota, Praveen, Roufosse, Florence, Rothenberg, Marc E, Jacobsen, Elizabeth A, Jackson, David J, Heffler, Enrico, Mathur, Sameer K, Bredenoord, Albert Jan, Pavord, Ian ID, Akuthota, Praveen, Roufosse, Florence, and Rothenberg, Marc E

Abstract

The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo, initially in mice and more recently in humans. Researchers using eosinophil knockout mice have identified a contributory role for eosinophils in basal and inflammatory processes and protective immunity. Primarily fueled by the purported proinflammatory role of eosinophils in eosinophil-associated diseases, a series of anti-eosinophil therapeutics have emerged as a new class of drugs. These agents, which dramatically deplete eosinophils, provide a valuable opportunity to characterize the consequences of eosinophil knockout humans. Herein, we comparatively describe mouse and human eosinophil knockouts. We put forth the view that human eosinophils negatively contribute to a variety of diseases and, unlike mouse eosinophils, do not yet have an identified role in physiological health; thus, clarifying all roles of eosinophils remains an ongoing pursuit., info:eu-repo/semantics/published

Published
2021

213. COVID-19 pandemic and allergen immunotherapy - an EAACI survey

Author

CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Pfaar, Oliver, Agache, Ioana, Bonini, Matteo, Brough, Helen Annaruth, Chivato, Tomás, Del Giacco, Stefano R, Gawlik, Radoslaw, Gelincik, Aslı, Hoffmann-Sommergruber, Karin, Jutel, Marek, Klimek, Ludger, Knol, Edward F, Lauerma, Antti, Ollert, Markus, O'Mahony, Liam, Mortz, Charlotte G, Palomares, Oscar, Riggioni, Carmen, Schwarze, Jürgen, Skypala, Isabel, Torres, María José, Untersmayr, Eva, Walusiak-Skorupa, Jolanta, Chaker, Adam, Giovannini, Mattia, Heffler, Enrico, Jensen-Jarolim, Erika, Quecchia, Cristina, Sandoval-Ruballos, Mónica, Sahiner, Umit, Tomić Spirić, Vesna, Alvaro-Lozano, Montserrat, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Pfaar, Oliver, Agache, Ioana, Bonini, Matteo, Brough, Helen Annaruth, Chivato, Tomás, Del Giacco, Stefano R, Gawlik, Radoslaw, Gelincik, Aslı, Hoffmann-Sommergruber, Karin, Jutel, Marek, Klimek, Ludger, Knol, Edward F, Lauerma, Antti, Ollert, Markus, O'Mahony, Liam, Mortz, Charlotte G, Palomares, Oscar, Riggioni, Carmen, Schwarze, Jürgen, Skypala, Isabel, Torres, María José, Untersmayr, Eva, Walusiak-Skorupa, Jolanta, Chaker, Adam, Giovannini, Mattia, Heffler, Enrico, Jensen-Jarolim, Erika, Quecchia, Cristina, Sandoval-Ruballos, Mónica, Sahiner, Umit, Tomić Spirić, Vesna, and Alvaro-Lozano, Montserrat

Published
2021

214. Revisiting Late-Onset Asthma: Clinical Characteristics and Association with Allergy

Author

Quirce,Santiago, Heffler,Enrico, Nenasheva,Natalia, Demoly,Pascal, Menzies-Gow,Andrew, Moreira-Jorge,Ana, Nissen,Francis, and Hanania,Nicola A

Subjects
parasitic diseases, Journal of Asthma and Allergy
Abstract

Santiago Quirce,1 Enrico Heffler,2 Natalia Nenasheva,3 Pascal Demoly,4 Andrew Menzies-Gow,5 Ana Moreira-Jorge,6 Francis Nissen,7 Nicola A Hanania8 1Department of Allergy, La Paz University Hospital, IdiPAZ and Universidad Autónoma de Madrid, Madrid, Spain; 2Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy; 3Department of Allergology and Immunology of Russian Medical Academy for Continuous Medical Education, Moscow, Russian Federation; 4Department of Pulmonology, Division of Allergy, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France; 5Department of Respiratory Medicine, Royal Brompton Hospital, London, UK; 6Novartis Farmaceutica, S.A., Barcelona, Spain; 7London School of Hygiene and Tropical Medicine, London, UK; 8Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USACorrespondence: Santiago QuirceHospital Universitario La Paz, P. La Castellana, 261, Madrid, 28046 SpainEmail squirce@gmail.comAbstract: The Global Initiative for Asthma (GINA) 2020 defines late-onset asthma (LOA) as one of the clinical phenotypes of asthma wherein patients, particularly women, present with asthma for the first time in adult life, tend to be non-allergic and often require higher doses of inhaled corticosteroids (ICS) or are relatively refractory to corticosteroid treatment. In this review, we examine the published literature improve the understanding of the following aspects of LOA: 1) the age cut-off for its diagnosis; 2) its distinct clinical phenotypes, characteristics and risk factors; and 3) its association with allergic comorbidities and conditions. Overall, our review reveals that clinicians and researchers have used multiple age cut-offs to define LOA, with cut-off ages ranging from > 12 years to ≥ 65 years. LOA has also been classified into several distinct phenotypes, some of which drastically differ in their clinical characteristics, course and prognosis. Although LOA has traditionally been considered non-allergic in nature, our review indicates that it is commonly associated with allergic features and comorbidities. Our findings suggest that there is an urgent need for the development of more clear clinical practice guidelines that can provide more clarity on the definition and other aspects of LOA. In addition, the association of LOA and allergy needs to be re-examined to frame a more optimal treatment strategy for patients with LOA.Keywords: asthma, diagnosis, age of onset, allergy, allergic asthma, asthma phenotypes

Published
2020

215. Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma

Author

Meghoufel, Z, Cherifi, F, Boukra, A, Terki, F, Porsbjerg, Celeste, Menzies-Gow, Andrew, Tran, Trung, Murray, Ruth, Unni, Bindhu, Audrey Ang, Shi Ling, Alacqua, Marianna, Al-Ahmad, Mona, Al-Lehebi, Riyad, Altraja, Alan, Belevskiy, Andrey, Björnsdóttir, Unnur, Bourdin, Arnaud, Busby, John, Canonica, G. Walter, Christoff, George, Cosio, Borja, Costello, Richard, FitzGerald, J. Mark, Fonseca, João, Hansen, Susanne, Heaney, Liam, Heffler, Enrico, Hew, Mark, Iwanaga, Takashi, Jackson, David, Kocks, Janwillem W.H., Kallieri, Maria, Bruce Ko, Hsin-Kuo, Koh, Mariko Siyue, Larenas-Linnemann, Désirée, Lehtimäki, Lauri, Loukides, Stelios, Lugogo, Njira, Maspero, Jorge, Papaioannou, Andriana, Perez-de-Llano, Luis, Pitrez, Paulo Márcio, Popov, Todor, Rasmussen, Linda, Rhee, Chin Kook, Sadatsafavi, Mohsen, Schmid, Johannes, Siddiqui, Salman, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos, Ulrik, Charlotte, Upham, John, Wang, Eileen, Wechsler, Michael, Bulathsinhala, Lakmini, Carter, Victoria, Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Rowlands, Mari-Anne, Price, David, van Boven, Job FM., Groningen Research Institute for Asthma and COPD (GRIAC), Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
Severe asthma, Biological Products, [SDV]Life Sciences [q-bio], Medizin, Biologics access, Omalizumab, 3. Good health, Biologics eligibility, Biological Therapy, 03 medical and health sciences, BIOLOGICS, 0302 clinical medicine, Prescriptions, 030228 respiratory system, Immunology and Allergy, Humans, ASTHMA, 030212 general & internal medicine, Anti-Asthmatic Agents, ComputingMilieux_MISCELLANEOUS, SEVERE ASTHMA
Abstract

BackgroundRegulatory bodies have approved five biologics for severe asthma. However, regional differences in accessibility may limit the global potential for personalized medicine.ObjectiveTo compare global differences in ease of access to biologics.MethodsIn April 2021, national prescription criteria for omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab were reviewed by severe asthma experts collaborating in the International Severe Asthma Registry. Outcomes (per country, per biologic) were (1) country-specific prescription criteria and (2) development of the Biologic Accessibility Score (BACS). The BACS composite score incorporates 10 prescription criteria, each with a maximum score of 10 points. Referenced to European Medicines Agency marketing authorization specifications, a higher score reflects easier access.ResultsBiologic prescription criteria differed substantially across 28 countries from five continents. Blood eosinophil count thresholds (usually ≥300 cells/μL) and exacerbations were key requirements for anti-IgE/anti–IL-5/5R prescriptions in around 80% of licensed countries. Most countries (40% for dupilumab to 54% for mepolizumab) require two or more moderate or severe exacerbations, whereas numbers ranged from none to four. Moreover, 0% (for reslizumab) to 21% (for omalizumab) of countries required long-term oral corticosteroid use. The BACS highlighted marked between-country differences in ease of access. For omalizumab, mepolizumab, benralizumab, and dupilumab, only two, one, four, and seven countries, respectively, scored equal or higher than the European Medicines Agency reference BACS. For reslizumab, all countries scored lower.ConclusionsAlthough some differences were expected in country-specific biologic prescription criteria and ease of access, the substantial differences found in the current study present a challenge to implementing precision medicine across the world.

Published
2022

220. A prevalent exposure to male dog is a risk factor for exclusive allergic sensitization to Can f 5: An Italian multicenter study

Author

Baiardini, Ilaria, Baldo, Ermanno, Bucca, Caterina, Canonica, Giorgio Walter, Heffler, Enrico, La Grutta, Stefania, Rolla, Giovanni, Rossi, Oliviero, Senna, Gianenrico, Sposato, Bruno, Tesi, Carlo Filippo, Viegi, Giovanni, Liccardi, Gennaro, Calzetta, Luigino, Bilò, Maria Beatrice, Brusca, Ignazio, Cecchi, Lorenzo, Costantino, Maria Teresa, Da Re, Mirella, Buzzulini, Francesca, Giani, Mauro, Lombardi, Carlo, Meneguzzi, Giorgia, Meriggi, Antonio, Milanese, Manlio, Onida, Rosa, Patella, Vincenzo, Pignatti, Patrizia, Quercia, Oliviero, Ridolo, Erminia, Sabatino, Giusy, Sacerdoti, Carlo, Savi, Eleonora, Scala, Enrico, Steinhilber, Gundi, Villalta, Danilo, Passalacqua, Giovanni, and Rogliani, Paola

Published
2020
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222. Das europäische Curriculum für die Zusatzbezeichnung Allergologie

Author

Mülleneisen, Norbert K., primary, Klimek, Ludger, additional, Worm, Margitta, additional, Merk, Hans F., additional, Rabe, Uta, additional, Biedermann, Tilo, additional, Jung, Kirsten, additional, Schlenter, Wolfgang W., additional, Ring, Johannes, additional, Chaker, Adam M., additional, Wehrmann, Wolfgang, additional, Brehler, Randolf, additional, Fuchs, Thomas, additional, Matricardi, Paolo, additional, Hamelmann, Eckard, additional, Jakob, Thilo, additional, Werfel, Thomas, additional, Wagenmann, Martin, additional, Taube, Christian, additional, Gerstlauer, Michael, additional, Vogelberg, Christian, additional, Roy Gerth, van Wijk, additional, Eguiluz-Gracia, Ibon, additional, Gayraud, Jacques, additional, Gutermuth, Jan, additional, Heffler, Enrico, additional, Popov, Todor A., additional, Schmid-Grendelmeier, Peter, additional, Tomazic, Peter V., additional, Tsilochristou, Olympia, additional, Giacco, Stefano Del, additional, Zuberbier, Torsten, additional, and Jutel, Marek, additional

Published
2021
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223. Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Lescure, François-Xavier, primary, Honda, Hitoshi, additional, Fowler, Robert A, additional, Lazar, Jennifer Sloane, additional, Shi, Genming, additional, Wung, Peter, additional, Patel, Naimish, additional, Hagino, Owen, additional, Bazzalo, Ignacio J., additional, Casas, Marcelo M., additional, Nuñez, Sebastián A., additional, Pere, Yael, additional, Ibarrola, Carlos M., additional, Solis Aramayo, Marco A., additional, Cuesta, Maria C., additional, Duarte, Andrea E., additional, Gutierrez Fernandez, Pablo M., additional, Iannantuono, Maria A., additional, Miyazaki, Erica A., additional, Silvio, Javier P., additional, Scublinsky, Dario G., additional, Bales, Alessandra, additional, Catarino, Daniela, additional, Fiss, Elie, additional, Mohrbacher, Sara, additional, Sato, Victor, additional, Baylao, Antonio, additional, Cavalcante, Adilson, additional, Correa, Francini, additional, de Andrade, Celso A., additional, Furtado, Juvencio, additional, Ribeiro Filho, Nelson, additional, Telles, Valéria, additional, Trevelin, Leopoldo T., additional, Vipich, Ricardo, additional, Boldo, Rodrigo, additional, Borges, Paula, additional, Lobo, Suzana, additional, Luckemeyer, Graziela, additional, Machado, Luana, additional, Alves, Maysa B., additional, Iglessias, Ana C., additional, Lago, Marianna M., additional, Santos, Daniel W., additional, Chapdelaine, Hugo, additional, Falcone, Emilia L., additional, Jamal, Rahima, additional, Luong, Me-Linh, additional, Durand, Madeleine, additional, Doucet, Stephane, additional, Carrier, François-Martin, additional, Coburn, Bryan A., additional, Del Sorbo, Lorenzo, additional, Walmsley, Sharon L., additional, Belga, Sara, additional, Chen, Luke Y., additional, Mah, Allison D., additional, Steiner, Theodore, additional, Wright, Alissa J., additional, Hajek, J., additional, Adhikari, Neill, additional, Fowler, Robert A., additional, Daneman, Nick, additional, Khwaja, Kosar A., additional, Shahin, Jason, additional, Gonzalez, Carolina, additional, Silva, Rafael, additional, Lindh, Marcelo, additional, Maluenda, Gabriel, additional, Fernandez, Patricia, additional, Oyonarte, Maite, additional, Lasso, Martin, additional, Boyer, Alexandre, additional, Bronnimann, Didier, additional, Bui, Hoang-Nam, additional, Cazanave, Charles, additional, Chaussade, Helene, additional, Desclaux, Arnaud, additional, Ducours, Mailys, additional, Duvignaud, Alexandre, additional, Malvy, Denis, additional, Martin, Lisa, additional, Neau, Didier, additional, Nguyen, Duc, additional, Pistone, Thierry, additional, Soubrane-Wirth, Gaetane, additional, Leitao, Julie, additional, Allavena, Clotilde, additional, Biron, Charlotte, additional, Bouchez, Sabelline, additional, Gaborit, Benjamin, additional, Gregoire, Antoine, additional, Le Turnier, Paul, additional, Lecompte, Anne-Sophie, additional, Lecomte, Raphael, additional, Lefebvre, Maeva, additional, Raffi, Francois, additional, Boutoille, David, additional, Morineau, Pascale H., additional, Guéry, Romain, additional, Chatelus, Emmanuel, additional, Dumoussaud, Nathalie, additional, Felten, Renaud, additional, Luca, Florina, additional, Goichot, Bernard, additional, Schneider, Francis, additional, Taquet, Marie-Caroline, additional, Groh, Matthieu, additional, Roumier, Mathilde, additional, Neuville, Mathilde, additional, Bachelard, Antoine, additional, Isernia, Valentina, additional, Lescure, F-Xavier, additional, Phung, Bao-Chau, additional, Rachline, Anne, additional, Sautereau, Aurelie, additional, Vallois, Dorothee, additional, Bleher, Yves, additional, Boucher, Delphine, additional, Coudon, Clémentine, additional, Esnault, Jean, additional, Guimard, Thomas, additional, Leautez-Nainville, Sophie, additional, Merrien, Dominique, additional, Morrier, Marine, additional, Motte-Vincent, Pauline, additional, Gabeff, Romain, additional, Leclerc, Hélène, additional, Cozic, Céline, additional, Decours, Romain, additional, Février, Ronan, additional, Colin, Gwenhael, additional, Abgrall, Sophie, additional, Vignes, Dorothee, additional, Sterpu, Raluca, additional, Kuellmar, Mira, additional, Meersch-Dini, Melanie, additional, Weiss, Raphael, additional, Zarbock, Alexander, additional, Antony, Christiane, additional, Berger, Marc, additional, Brenner, Thorsten, additional, Taube, Christian, additional, Herbstreit, Frank, additional, Dolff, Sebastian, additional, Konik, Margarethe, additional, Schmidt, Karsten, additional, Zettler, Markus, additional, Witzke, Oliver, additional, Boell, Boris, additional, Garcia Borrega, Jorge, additional, Koehler, Philipp, additional, Zander, Thomas, additional, Dusse, Fabian, additional, Al-Sawaf, Othman, additional, Köhler, Philipp, additional, Eichenauer, Dennis, additional, Kochanek, Matthias, additional, Shimabukuro-Vornhagen, Alexander, additional, Mellinghoff, Sibylle, additional, Claßen, Annika, additional, Heger, Jan-Michel, additional, Meyer-Schwickerath, Charlotte, additional, Liedgens, Paul, additional, Heindel, Katrin, additional, Belkin, Ana, additional, Biber, Asaf, additional, Gilboa, Mayan, additional, Levy, Itzchak, additional, Litachevsky, Vladislav, additional, Rahav, Galia, additional, Finesod Wiedner, Anat, additional, Zilberman-Daniels, Tal, additional, Oster, Yonatan, additional, Strahilevitz, Jacob, additional, Sviri, Sigal, additional, Baldissera, Elena M., additional, Campochiaro, Corrado, additional, Cavalli, Giulio, additional, Dagna, Lorenzo, additional, De Luca, Giacomo, additional, Della Torre, Emanuel, additional, Tomelleri, Alessandro, additional, Bernasconi De Luca, Davide, additional, Capetti, Amedeo F., additional, Coen, Massimo, additional, Cossu, Maria V., additional, Galli, Massimo, additional, Giacomelli, Andrea, additional, Gubertini, Guido A., additional, Rusconi, Stefano, additional, Burastero, Giulia J., additional, Digaetano, Margherita, additional, Guaraldi, Giovanni, additional, Meschiari, Marianna, additional, Mussini, Cristina, additional, Puzzolante, Cinzia, additional, Volpi, Sara, additional, Aiello, Marina, additional, Ariani, Alarico, additional, Chetta, Alfredo A., additional, Frizzelli, Annalisa, additional, Ticinesi, Andrea, additional, Tuttolomondo, Domenico, additional, Aliberti, Stefano, additional, Blasi, Francesco B., additional, Di Pasquale, Marta F., additional, Misuraca, Sofia, additional, Pilocane, Tommaso, additional, Simonetta, Edoardo, additional, Aghelmo, Alessio M., additional, Angelini, Claudio, additional, Brunetta, Enrico, additional, Canonica, Giorgio W., additional, Ciccarelli, Michele, additional, Dal Farra, Sara, additional, De Santis, Maria, additional, Ferri, Sebastian, additional, Folci, Marco, additional, Guidelli, Giacomo M., additional, Heffler, Enrico M., additional, Loiacono, Ferdinando, additional, Malipiero, Giacomo, additional, Paoletti, Giovanni, additional, Pedale, Rosa, additional, Puggioni, Francesca A., additional, Racca, Francesca, additional, Zumbo, Aurora, additional, Satou, Morihiko, additional, Lisun, Tatyana, additional, Protsenko, Denis, additional, Rubtsov, Nikolay, additional, Beloglazova, Irina, additional, Fomina, Daria, additional, Lysenko, Mariana, additional, Serdotetskova, Sofia, additional, Firstov, Vitali, additional, Gordeev, Ivan, additional, Kokorin, Ilia, additional, Komissarova, Ksenia, additional, Lapochkina, Nina, additional, Luchinkina, Elena, additional, Malimon, Valentin, additional, Mamedguseyinova, Sevinch, additional, Polubatonova, Ksenia, additional, Suvorova, Natalia, additional, Arribas, Jose, additional, Borobia Perez, Alberto M., additional, de la Calle Prieto, Fernando, additional, Figueira, Juan Carlos, additional, Motejano Sanchez, Rocio, additional, Mora-Rillo, Marta, additional, Prados Sanchez, Concepcion, additional, Queiruga Parada, Javier, additional, Fernandez Arnalich, Francisco, additional, Guerro Barrientos, Maria, additional, Bendala Estrada, Alejandro, additional, Caballero Marcos, Aranzazu, additional, Garcia Leoni, Maria E., additional, García-Martínez, Rita, additional, Collado, Ana María, additional, Munoz Garcia, Patricia, additional, Torres do Rego, Ana, additional, Villalba García, María V., additional, Burrillo, Almudena, additional, Valerio Minero, Maricela, additional, Gijon Vidaurreta, Paloma, additional, Infante Herrero, Sonsoles, additional, Velilla, Elena, additional, Machado, Marina, additional, Olmedo, Maria, additional, Pinilla, Blanca, additional, Almirante Gragera, Benito, additional, Cañas Ruano, Maria de la Esperanza, additional, Contreras Medina, Sofia, additional, Cortés Herrera, Alejandro, additional, Falcó Ferrer, Vicenç, additional, Ferrer Roca, Ricard, additional, Nuvials Casals, Xavier, additional, Ribera Pascuet, Esteve, additional, Suanzes Diez, Paula, additional, Rebollo Castro, Pedro, additional, Garcia Alcaide, Felipe, additional, Soriano, Alejandro, additional, Oliver Caldes, Aina, additional, González Cordón, Ana, additional, Cardozo, Celia, additional, De la Mora Cañizo, Lorena, additional, Pena López, Romina, additional, Chamorro, Sandra, additional, Crespillo-Andujar, Clara, additional, Escudero Sanchez, Rosa, additional, Fortún-Abete, Jesús, additional, Monge-Maillo, Begoña, additional, Moreno Zamora, Ana, additional, Norman, Francesca, additional, Sanchez Conde, Matilde, additional, Serrano Villar, Sergio, additional, and Vizcarra, Pilar, additional

Published
2021
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225. Real-life survey on severe asthma patients during COVID-19 lockdown in Italy

Author

Caruso, Cristiano, primary, Colantuono, Stefania, additional, Urbani, Sara, additional, Heffler, Enrico, additional, Canonica, Giorgio Walter, additional, Andriollo, Gloria, additional, Di Michele, Loreta, additional, Scarlata, Simone, additional, Zennaro, Danila, additional, Rigon, Amelia, additional, Vadacca, Marta, additional, Moroni, Rossana, additional, Nucera, Eleonora, additional, and Gasbarrini, Antonio, additional

Published
2021
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226. Manifesto on united airways diseases (UAD): an Interasma (global asthma association – GAA) document

Author

Tiotiu, Angelica, primary, Novakova, Plamena, additional, Baiardini, Ilaria, additional, Bikov, Andras, additional, Chong-Neto, Herberto, additional, de-Sousa, Jaime Correia-, additional, Emelyanov, Alexander, additional, Heffler, Enrico, additional, Fogelbach, Guillermo Guidos, additional, Kowal, Krzysztof, additional, Labor, Marina, additional, Mihaicuta, Stefan, additional, Nedeva, Denislava, additional, Novakova, Sylvia, additional, Steiropoulos, Paschalis, additional, Ansotegui, Ignacio J., additional, Bernstein, Jonathan A., additional, Boulet, Louis-Philippe, additional, Canonica, Giorgio Walter, additional, Dubuske, Lawrence, additional, Nunes, Carlos, additional, Ivancevich, Juan Carlos, additional, Santus, Pierachille, additional, Rosario, Nelson, additional, Perazzo, Tommaso, additional, and Braido, Fulvio, additional

Published
2021
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228. Additional file 1 of International severe asthma registry (ISAR): protocol for a global registry

Author

J. Mark FitzGerald, Tran, Trung N., Alacqua, Marianna, Altraja, Alan, Backer, Vibeke, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Brusselle, Guy, Lakmini Bulathsinhala, Busby, John, Canonica, Giorgio W., Carter, Victoria, Isha Chaudhry, Cho, You Sook, Christoff, George, Cosio, Borja G., Costello, Richard W., Eleangovan, Neva, Gibson, Peter G., Heaney, Liam G., Heffler, Enrico, Hew, Mark, Naeimeh Hosseini, Iwanaga, Takashi, Jackson, David J., Jones, Rupert, Koh, Mariko S., Le, Thao, Lehtimäki, Lauri, Ludviksdottir, Dora, Zee, Anke H. Maitland-Van Der, Menzies-Gow, Andrew, Murray, Ruth B., Papadopoulos, Nikolaos G., Perez-De-Llano, Luis, Peters, Matthew, Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Price, Chris A., Rhee, Chin K., Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Zangrilli, James, and Price, David B.

Subjects
surgical procedures, operative, education, macromolecular substances, digestive system, digestive system diseases
Abstract

Additional file 1: Appendix. International Severe Asthma Registry study group.

Published
2020
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229. Additional file 3 of International severe asthma registry (ISAR): protocol for a global registry

Author

J. Mark FitzGerald, Tran, Trung N., Alacqua, Marianna, Altraja, Alan, Backer, Vibeke, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Brusselle, Guy, Lakmini Bulathsinhala, Busby, John, Canonica, Giorgio W., Carter, Victoria, Isha Chaudhry, Cho, You Sook, Christoff, George, Cosio, Borja G., Costello, Richard W., Eleangovan, Neva, Gibson, Peter G., Heaney, Liam G., Heffler, Enrico, Hew, Mark, Naeimeh Hosseini, Iwanaga, Takashi, Jackson, David J., Jones, Rupert, Koh, Mariko S., Le, Thao, Lehtimäki, Lauri, Ludviksdottir, Dora, Zee, Anke H. Maitland-Van Der, Menzies-Gow, Andrew, Murray, Ruth B., Papadopoulos, Nikolaos G., Perez-De-Llano, Luis, Peters, Matthew, Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Price, Chris A., Rhee, Chin K., Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Zangrilli, James, and Price, David B.

Subjects
nervous system, education, macromolecular substances, health care economics and organizations, respiratory tract diseases
Abstract

Additional file 3: Table S2. International Severe Asthma Registry bolt-on variables.

Published
2020
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230. Additional file 3 of Effectiveness of omalizumab in patients with severe allergic asthma with and without chronic rhinosinusitis with nasal polyps: a PROXIMA study post hoc analysis

Author

Heffler, Enrico, Saccheri, Fabiana, Bartezaghi, Marta, and Canonica, Giorgio Walter

Abstract

Additional file 3: Figure S3. Efficacy comparison of outcome parameters at baseline and 12 months after omalizumab treatment in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) compared with severe asthma (no chronic rhinosinusitis or nasal polyps). (A) Mean Asthma Control Questionnaire scores, and the change from baseline in ACQ score; (B) Median percent predicted forced expiratory volume in 1 s (FEV1), and change from baseline in percent predicted FEV1; (C) Median number of annual exacerbations in the year prior to initiating omalizumab treatment (baseline) and during 12 months’ treatment with omalizumab, and change from baseline. The p-values within cohorts were calculated using a signed rank test and p-values for comparisons between cohorts were calculated using an ANCOVA model on ranks.

Published
2020
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231. Alpha1-antitrypsin deficiency and asthma

Author

Pini, Laura, Paoletti, Giovanni, Heffler, Enrico, Tantucci, Claudio, Puggioni, Francesca, Corsico, Angelo, Del Giacco, Stefano, Ferri, Sebastian, Giordani, Jordan, Paggiaro, Pierluigi, Pini, Alessandro, and Spanevello, Antonio

Subjects
severe asthma, Immunology, Population, Disease, Severity of Illness Index, Proinflammatory cytokine, phenoendotyping asthma, alpha 1-Antitrypsin Deficiency, Immunology and Allergy, Medicine, Humans, a1-antitrypsin, education, a1-antitrypsin polymers, Asthma, education.field_of_study, Lung, a1-antitrypsin, a1-antitrypsin deficiency, a1-antitrypsin polymers, asthma, neutrophil asthma, phenoendotyping asthma, severe asthma, business.industry, Mechanism (biology), Elastase, asthma, medicine.disease, respiratory tract diseases, neutrophil asthma, Increased risk, medicine.anatomical_structure, alpha 1-Antitrypsin, a1-antitrypsin deficiency, business, Leukocyte Elastase, Signal Transduction
Abstract

PURPOSE OF REVIEW The aim of the article is to highlight the association between α1-antitrypsin deficiency (AATD) and asthma. RECENT FINDINGS AATD is one of the most common and underrecognized autosomal disorders associated with an increased risk of developing liver and lung diseases. An association between α1-antitrypsin and asthma has been suggested, especially with severe forms of this disease. Many studies have shown an increased prevalence of asthma in the α1-antitrypsin-deficient population overtime (4-38%). The biological mechanism underlying these two conditions and able to bind them has not yet been well investigated. As α1-antitrypsin is the main inhibitor of the serine proteinase and it is an important anti-inflammatory protein with pronounced immunomodulatory activities, it can be hypothesized that the link between AATD and asthma might be represented by the elastase/antielastase imbalance and the proinflammatory effect that occurs because of the reduction of this protein. SUMMARY There is a strong need for further researches to better understand the molecular mechanisms binding AATD and asthma. It is also recommendable to screen for AATD, late-onset asthma patients, and/or those with not fully reversible airways obstruction.

Published
2020

232. Reply to: Kow CS et al. Are severe asthma patients at higher risk of developing severe outcomes from COVID-19?

Author

Heffler, Enrico, Detoraki, Aikaterini, Contoli, Marco, Papi, Alberto, Paoletti, Giovanni, Malipiero, Giacomo, Brussino, Luisa, Crimi, Claudia, Morrone, Daniela, Padovani, Marianna, Guida, Giuseppe, Gerli, Alberto Giovanni, Centanni, Stefano, Senna, Gianenrico, Paggiaro, Pierluigi, Blasi, Francesco, Canonica, Giorgio Walter, SANI Working Group, Bonavia, M., Bucca, C., Caiaffa, M. F., Calabrese, C., Camiciottoli, G., Caruso, C., Conte, M. E., Corsico, A. G., Cosmi, L., Costantino, M. T., Crimi, N., D’Alò, S., D’Amato, M., Del Giacco, S., Farsi, A., Favero, E., Foschino, B. M. P., Guarnieri, G., Lo Cicero, S., Lombardi, C., Macchia, L., Mazza, F., Menzella, F., Milanese, M., Montuschi, P., Montagni, M., Nucera, E., Parente, R., Passalacqua, G., Patella, V., Pelaia, G., Pini, L., Puggioni, F., Ricciardi, L., Ricciardolo, F. L. M., Richeldi, L., Ridolo, E., Rolla, G., Santus, P., Scichilone, N., Solidoro, P., Spadaro, G., Vianello, A., Viviano, V., Yacoub, M. R., Zappa, M. C., Heffler E., Detoraki A., Contoli M., Papi A., Paoletti G., Malipiero G., Brussino L., Crimi C., Morrone D., Padovani M., Guida G., Gerli A.G., Centanni S., Senna G., Paggiaro P., Blasi F., Canonica G.W., Bonavia M., Bucca C., Caiaffa M.F., Calabrese C., Camiciottoli G., Caruso C., Conte M.E., Corsico A.G., Cosmi L., Costantino M.T., Crimi N., D'Alo S., D'Amato M., Del Giacco S., Farsi A., Favero E., Foschino B.M.P., Guarnieri G., Lo Cicero S., Lombardi C., Macchia L., Mazza F., Menzella F., Milanese M., Montuschi P., Montagni M., Nucera E., Parente R., Passalacqua G., Patella V., Pelaia G., Pini L., Puggioni F., Ricciardi L., Ricciardolo F.L.M., Richeldi L., Ridolo E., Rollav G., Santus P., Scichilone N., Solidoro P., Spadaro G., Vianello A., Viviano V., Yacoub M.R., and Zappa M.C.

Subjects
severe asthma, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Severe asthma, Immunology, Comorbidity, Settore MED/10 - Malattie Dell'Apparato Respiratorio, COVID-19, severe asthma, COPD, NO, Humans, SARS-CoV-2, Asthma, COVID-19, Internal medicine, Correspondence, medicine, COPD, Immunology and Allergy, COVID, business.industry, asthma, medicine.disease, Italy, business
Published
2020

233. Additional file 1 of Effectiveness of omalizumab in patients with severe allergic asthma with and without chronic rhinosinusitis with nasal polyps: a PROXIMA study post hoc analysis

Author

Heffler, Enrico, Saccheri, Fabiana, Bartezaghi, Marta, and Canonica, Giorgio Walter

Abstract

Additional file 1: Figure S1. Efficacy comparison of outcome parameters at baseline and 12 months after omalizumab treatment in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) compared with chronic sinusitis/rhinosinusutis without (CRSsNP). (A) Mean Asthma Control Questionnaire scores, and the change from baseline in ACQ score; (B) Median percent predicted forced expiratory volume in 1 s (FEV1), and change from baseline in percent predicted FEV1; (C) Median number of annual exacerbations in the year prior to initiating omalizumab treatment (baseline) and during 12 months’ treatment with omalizumab, and change from baseline. The p-values within cohorts were calculated using a signed rank test and p-values for comparisons between cohorts were calculated using an ANCOVA model on ranks.

Published
2020
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234. Additional file 4 of International severe asthma registry (ISAR): protocol for a global registry

Author

J. Mark FitzGerald, Tran, Trung N., Alacqua, Marianna, Altraja, Alan, Backer, Vibeke, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Brusselle, Guy, Lakmini Bulathsinhala, Busby, John, Canonica, Giorgio W., Carter, Victoria, Isha Chaudhry, Cho, You Sook, Christoff, George, Cosio, Borja G., Costello, Richard W., Eleangovan, Neva, Gibson, Peter G., Heaney, Liam G., Heffler, Enrico, Hew, Mark, Naeimeh Hosseini, Iwanaga, Takashi, Jackson, David J., Jones, Rupert, Koh, Mariko S., Le, Thao, Lehtimäki, Lauri, Ludviksdottir, Dora, Zee, Anke H. Maitland-Van Der, Menzies-Gow, Andrew, Murray, Ruth B., Papadopoulos, Nikolaos G., Perez-De-Llano, Luis, Peters, Matthew, Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Price, Chris A., Rhee, Chin K., Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Zangrilli, James, and Price, David B.

Subjects
education, macromolecular substances, health care economics and organizations, respiratory tract diseases
Abstract

Additional file 4: Table S3. International Severe Asthma Registry optional additional research variables.

Published
2020
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235. Additional file 2 of International severe asthma registry (ISAR): protocol for a global registry

Author

J. Mark FitzGerald, Tran, Trung N., Alacqua, Marianna, Altraja, Alan, Backer, Vibeke, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Brusselle, Guy, Lakmini Bulathsinhala, Busby, John, Canonica, Giorgio W., Carter, Victoria, Isha Chaudhry, Cho, You Sook, Christoff, George, Cosio, Borja G., Costello, Richard W., Eleangovan, Neva, Gibson, Peter G., Heaney, Liam G., Heffler, Enrico, Hew, Mark, Naeimeh Hosseini, Iwanaga, Takashi, Jackson, David J., Jones, Rupert, Koh, Mariko S., Le, Thao, Lehtimäki, Lauri, Ludviksdottir, Dora, Zee, Anke H. Maitland-Van Der, Menzies-Gow, Andrew, Murray, Ruth B., Papadopoulos, Nikolaos G., Perez-De-Llano, Luis, Peters, Matthew, Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Price, Chris A., Rhee, Chin K., Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Zangrilli, James, and Price, David B.

Abstract

Additional file 2: Table S1. Full list of ISAR 95 core variables.

Published
2020
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237. An Emerging Role for Exhaled Nitric Oxide in Guiding Biological Treatment in Severe Asthma

Author

Rolla, Giovanni, Heffler, Enrico, Pizzimenti, Stefano, Michils, Alain, Malinovschi, Andrei, Rolla, Giovanni, Heffler, Enrico, Pizzimenti, Stefano, Michils, Alain, and Malinovschi, Andrei

Abstract

Asthma is a heterogeneous disease with regard to the inflammatory pathways activated. In recent years, biologic drugs (monoclonal antibodies) directed towards specific components of type 2 inflammation have been approved for the treatment of severe asthma. Phenotyping of patients with severe asthma and evaluation of biomarkers have been recommended to help identify patients who are candidates for treatment with biologics and to monitor treatment responses. Fractional exhaled Nitric Oxide (FeNO) is a biomarker of type 2 inflammation in asthma, signaling activation of Interleukin (IL)-4/IL-13 pathway. FeNO could be useful to assess treatment response or identify candidates for a specific drug that acts on type 2 inflammation mechanisms linked to Nitric Oxide (NO) production, such as the IL-4/IL-13 pathway or upstream processes. The value of FeNO as a biomarker predictive of responses to the biologics available for treating severe asthma is discussed based on the published studies at the moment of the review.

Published
2020
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238. Frequency of Tiotropium Bromide Use and Clinical Features of Patients with Severe Asthma in a Real-Life Setting: Data from the Severe Asthma Network in Italy (SANI) Registry

Author

Puggioni,Francesca, Brussino,Luisa, Canonica,Giorgio Walter, Blasi,Francesco, Paggiaro,Pierluigi, Caminati,Marco, Latorre,Manuela, Heffler,Enrico, Senna,Gianenrico, Puggioni,Francesca, Brussino,Luisa, Canonica,Giorgio Walter, Blasi,Francesco, Paggiaro,Pierluigi, Caminati,Marco, Latorre,Manuela, Heffler,Enrico, and Senna,Gianenrico

Abstract

Francesca Puggioni,1,2 Luisa Brussino,3 Giorgio Walter Canonica,1,2 Francesco Blasi,4,5 Pierluigi Paggiaro,6 Marco Caminati,7,8 Manuela Latorre,6 Enrico Heffler,1,2 Gianenrico Senna7,8 On behalf of the Severe Asthma Network in Italy (SANI) group1Personalized Medicine, Asthma and Allergy – Humanitas Clinical and Research Center, IRCCS – Rozzano (MI), Milan, Italy; 2Department of Biomedical Sciences, Humanitas University – Pieve Emanuele (MI), Milan, Italy; 3Dipartimento di Scienze Mediche, SSDDU Allergologia e Immunologia Clinica, Università degli Studi di Torino, AO Ordine Mauriziano Umberto I – Torino, Torino, Italy; 4Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; 5Internal Medicine Department, Respiratory Unit and Adult Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy; 6Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy; 7Department of Medicine, University of Verona, Verona, Italy; 8Allergy Unit and Asthma Center, Verona University Hospital, Verona, Verona, ItalyCorrespondence: Enrico HefflerPersonalized Medicine, Asthma and Allergy, Istituto Clinico Humanitas, Milan, ItalyTel +39 0288247013Fax + 39 0282246484Email enrico.heffler@hunimed.euPurpose: Patients with uncontrolled asthma despite high doses of inhaled corticosteroid therapy plus another controller are defined as severe asthmatics. Tiotropium bromide respimat (TBR) is the only long-acting muscarinic antagonists (LAMA) approved for severe asthma. The aim of this study was to explore the frequency of severe asthmatics treated with TBR and characterize their clinical features in a real-life, registry-based setting.Materials and Methods: Baseline data from the Severe Asthma Network in Italy (SANI) registry have been analyzed to determine the use of TBR and other LAMA, and to compare clinical, functional a

Published
2020

239. Characteristics and treatment regimens across ERS SHARP severe asthma registries.

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, van Bragt, Job J M H, Adcock, Ian M, Bel, Elisabeth H D, Braunstahl, Gert-Jan, Ten Brinke, Anneke, Busby, John, Canonica, Giorgio W, Cao, Hui, Chung, Kian Fan, Csoma, Zsuzsanna, Dahlén, Barbro, Davin, Elizabeth, Hansen, Susanne, Heffler, Enrico, Horvath, Ildiko, Korn, Stephanie, Kots, Maxim, Kuna, Piotr, Kwon, Namhee, Louis, Renaud, Plaza, Vicente, Porsbjerg, Celeste, Ramos-Barbon, David, Richards, Levi B, Škrgat, Sabina, Sont, Jacob K, Vijverberg, Susanne J H, Weersink, Els J M, Yasinska, Valentyna, Wagers, Scott S, Djukanovic, Ratko, Maitland-van der Zee, Anke H, SHARP Clinical Research Collaboration, Members of the SHARP Clinical Research Collaboration are, Vandenplas, Olivier, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, van Bragt, Job J M H, Adcock, Ian M, Bel, Elisabeth H D, Braunstahl, Gert-Jan, Ten Brinke, Anneke, Busby, John, Canonica, Giorgio W, Cao, Hui, Chung, Kian Fan, Csoma, Zsuzsanna, Dahlén, Barbro, Davin, Elizabeth, Hansen, Susanne, Heffler, Enrico, Horvath, Ildiko, Korn, Stephanie, Kots, Maxim, Kuna, Piotr, Kwon, Namhee, Louis, Renaud, Plaza, Vicente, Porsbjerg, Celeste, Ramos-Barbon, David, Richards, Levi B, Škrgat, Sabina, Sont, Jacob K, Vijverberg, Susanne J H, Weersink, Els J M, Yasinska, Valentyna, Wagers, Scott S, Djukanovic, Ratko, Maitland-van der Zee, Anke H, SHARP Clinical Research Collaboration, Members of the SHARP Clinical Research Collaboration are, and Vandenplas, Olivier

Abstract

Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals.This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases.Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day between those from Slovenia Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day in those starting anti-IgE (Slovenia Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively.The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.

Published
2020

240. The hidden burden of severe asthma: from patient perspective to new opportunities for clinicians

Author

Scichilone, Nicola, Barnes, John, Battaglia, Salvatore, Benfante, Alida, Brown, Robert, Canonica, Giorgio Walter, Caramori, Gaetano, Cazzola, Mario, Centanni, Stefano, Cianferoni, Antonella, Corsico, Angelo, De Carlo, Giuseppe, Di Marco, Fabiano, Gaga, Mina, Hawrylowicz, Catherine, Heffler, Enrico, Matera, Maria Gabriella, Matucci, Andrea, Paggiaro, Pierluigi, Papi, Alberto, Popov, Todor, Rogliani, Paola, Santus, Pierachille, Solidoro, Paolo, Togias, Alkis, Boulet, Louis-Philippe, Scichilone, Nicola, Barnes, John, Battaglia, Salvatore, Benfante, Alida, Brown, Robert, Canonica, Giorgio Walter, Caramori, Gaetano, Cazzola, Mario, Centanni, Stefano, Cianferoni, Antonella, Corsico, Angelo, De Carlo, Giuseppe, Di Marco, Fabiano, Gaga, Mina, Hawrylowicz, Catherine, Heffler, Enrico, Matera, Maria Gabriella, Matucci, Andrea, Paggiaro, Pierluigi, Papi, Alberto, Popov, Todor, Rogliani, Paola, Santus, Pierachille, Solidoro, Paolo, Togias, Alkis, and Boulet, Louis-Philippe

Abstract

Severe asthma is an important topic in respiratory diseases, due to its high impact on morbidity and mortality as well as on health-care resources. The many challenges that still exist in the management of the most difficult-to-treat forms of the disease, and the acknowledgement of the existence of unexplored areas in the pathophysiological mechanisms and the therapeutic targets represent an opportunity to gather experts in the field with the immediate goals to summarize current understanding about the natural history of severe asthma and to identify gaps in knowledge and research opportunities, with the aim to contribute to improved medical care and health outcomes. This article is a consensus document from the “International Course on Severe Asthma” that took place in Palermo, Italy, on May 10–11, 2019. Emerging topics in severe asthma were addressed and discussed among experts, with special focus on patient’s needs and research opportunities, with the aim to highlight the unanswered questions in the diagnostic process and therapeutic approach.

Published
2020

241. ARIA digital anamorphosis:Digital transformation of health and care in airway diseases from research to practice

Author

Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T.T., Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga M., Melén, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhân, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagaña, Xavier, D. Bateman, Eric, Bédard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean François, Fuentes Perez, José M., Gemicioğlu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, René Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michaël, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Björn, Novellino, Ettore, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Schöll, Isabella, Panzner, Peter, Park, Hae Sim, Passalacqua, Gianni, Pépin, Jean Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Söderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schünemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, François, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stéphane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, Zidarn, Mihaela, Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T.T., Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga M., Melén, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhân, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagaña, Xavier, D. Bateman, Eric, Bédard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean François, Fuentes Perez, José M., Gemicioğlu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, René Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michaël, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Björn, Novellino, Ettore, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Schöll, Isabella, Panzner, Peter, Park, Hae Sim, Passalacqua, Gianni, Pépin, Jean Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Söderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schünemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, François, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stéphane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, and Zidarn, Mihaela

Abstract

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.

Published
2020

242. International Severe Asthma Registry:Mission Statement

Author

Canonica, G. Walter, Alacqua, Marianna, Altraja, Alan, Backer, Vibeke, Bel, Elisabeth, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Brusselle, Guy G., Christoff, George C., Cosio, Borja G., Costello, Richard W., FitzGerald, J. Mark, Gibson, Peter G., Heaney, Liam G., Heffler, Enrico, Hew, Mark, Iwanaga, Takashi, Jones, Rupert C., Siyue, Mariko Koh, Rhee, Chin Kook, Lehmann, Sverre, Lehtimäki, Lauri A., Ludviksdottir, Dora, Maitland-van der Zee, Anke Hilse, Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Plaza, Vicente, Perez de Llano, Luis, Peters, Matthew, Porsbjerg, Celeste M., Sadatsafavi, Mohsen, Cho, You Sook, Tohda, Yuji, Tran, Trung N., Wang, Eileen, Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Le, Thao L., Murray, Ruth B., Price, Chris A., Price, David B., Canonica, G. Walter, Alacqua, Marianna, Altraja, Alan, Backer, Vibeke, Bel, Elisabeth, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Brusselle, Guy G., Christoff, George C., Cosio, Borja G., Costello, Richard W., FitzGerald, J. Mark, Gibson, Peter G., Heaney, Liam G., Heffler, Enrico, Hew, Mark, Iwanaga, Takashi, Jones, Rupert C., Siyue, Mariko Koh, Rhee, Chin Kook, Lehmann, Sverre, Lehtimäki, Lauri A., Ludviksdottir, Dora, Maitland-van der Zee, Anke Hilse, Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Plaza, Vicente, Perez de Llano, Luis, Peters, Matthew, Porsbjerg, Celeste M., Sadatsafavi, Mohsen, Cho, You Sook, Tohda, Yuji, Tran, Trung N., Wang, Eileen, Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Le, Thao L., Murray, Ruth B., Price, Chris A., and Price, David B.

Abstract

Regional and/or national severe asthma registries provide valuable country-specific information. However, they are often limited in scope within the broader definitions of severe asthma, have insufficient statistical power to answer many research questions, lack intraoperability to share lessons learned, and have fundamental differences in data collected, making cross comparisons difficult. What is missing is a worldwide registry which brings all severe asthma data together in a cohesive way, under a single umbrella, based on standardized data collection protocols, permitting data to be shared seamlessly. The International Severe Asthma Registry (ISAR; http://isaregistries.org/) is the first global adult severe asthma registry. It is a joint initiative where national registries (both newly created and preexisting) retain ownership of their own data but open their borders and share data with ISAR for ethically approved research purposes. Its strength comes from collection of patient-level, anonymous, longitudinal, real-life, standardized, high-quality data (using a core set of variables) from countries across the world, combined with organizational structure, database experience, inclusivity/openness, and clinical, academic, and database expertise. This gives ISAR sufficient statistical power to answer important research questions, sufficient data standardization to compare across countries and regions, and the structure and expertise necessary to ensure its continuance and the scientific integrity and clinical applicability of its research. ISAR offers a unique opportunity to implement existing knowledge, generate new knowledge, and identify the unknown, therefore promoting new research. The aim of this commentary is to fully describe how ISAR may improve our understanding of severe asthma.

Published
2020

243. Characteristics and treatment regimens across ERS SHARP severe asthma registries

Author

van Bragt, Job J M H, Adcock, Ian M, Bel, Elisabeth H D, Braunstahl, Gert-Jan, Ten Brinke, Anneke, Busby, John, Canonica, Giorgio W, Cao, Hui, Chung, Kian Fan, Csoma, Zsuzsanna, Dahlén, Barbro, Davin, Elizabeth, Hansen, Susanne, Heffler, Enrico, Horvath, Ildiko, Korn, Stephanie, Kots, Maxim, Kuna, Piotr, Kwon, Namhee, Louis, Renaud, Plaza, Vicente, Porsbjerg, Celeste, Ramos-Barbon, David, Richards, Levi B, Škrgat, Sabina, Sont, Jacob K, Vijverberg, Susanne J H, Weersink, Els J M, Yasinska, Valentyna, Wagers, Scott S, Djukanovic, Ratko, Maitland-van der Zee, Anke H, van Bragt, Job J M H, Adcock, Ian M, Bel, Elisabeth H D, Braunstahl, Gert-Jan, Ten Brinke, Anneke, Busby, John, Canonica, Giorgio W, Cao, Hui, Chung, Kian Fan, Csoma, Zsuzsanna, Dahlén, Barbro, Davin, Elizabeth, Hansen, Susanne, Heffler, Enrico, Horvath, Ildiko, Korn, Stephanie, Kots, Maxim, Kuna, Piotr, Kwon, Namhee, Louis, Renaud, Plaza, Vicente, Porsbjerg, Celeste, Ramos-Barbon, David, Richards, Levi B, Škrgat, Sabina, Sont, Jacob K, Vijverberg, Susanne J H, Weersink, Els J M, Yasinska, Valentyna, Wagers, Scott S, Djukanovic, Ratko, and Maitland-van der Zee, Anke H

Abstract

Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals.This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases.Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m-2 (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day-1 between those from Slovenia versus Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day-1 in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively.The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.

Published
2020

244. International severe asthma registry (ISAR):protocol for a global registry

Author

FitzGerald, J Mark, Tran, Trung N, Alacqua, Marianna, Altraja, Alan, Backer, Vibeke, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Brusselle, Guy, Bulathsinhala, Lakmini, Busby, John, Canonica, Giorgio W, Carter, Victoria, Chaudhry, Isha, Cho, You Sook, Christoff, George, Cosio, Borja G, Costello, Richard W, Eleangovan, Neva, Gibson, Peter G, Heaney, Liam G, Heffler, Enrico, Hew, Mark, Hosseini, Naeimeh, Iwanaga, Takashi, Jackson, David J, Jones, Rupert, Koh, Mariko S, Le, Thao, Lehtimäki, Lauri, Ludviksdottir, Dora, Maitland-van der Zee, Anke H, Menzies-Gow, Andrew, Murray, Ruth B, Papadopoulos, Nikolaos G, Perez-de-Llano, Luis, Peters, Matthew, Pfeffer, Paul E, Popov, Todor A, Porsbjerg, Celeste M, Price, Chris A, Rhee, Chin K, Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E, Zangrilli, James, Price, David B, FitzGerald, J Mark, Tran, Trung N, Alacqua, Marianna, Altraja, Alan, Backer, Vibeke, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Brusselle, Guy, Bulathsinhala, Lakmini, Busby, John, Canonica, Giorgio W, Carter, Victoria, Chaudhry, Isha, Cho, You Sook, Christoff, George, Cosio, Borja G, Costello, Richard W, Eleangovan, Neva, Gibson, Peter G, Heaney, Liam G, Heffler, Enrico, Hew, Mark, Hosseini, Naeimeh, Iwanaga, Takashi, Jackson, David J, Jones, Rupert, Koh, Mariko S, Le, Thao, Lehtimäki, Lauri, Ludviksdottir, Dora, Maitland-van der Zee, Anke H, Menzies-Gow, Andrew, Murray, Ruth B, Papadopoulos, Nikolaos G, Perez-de-Llano, Luis, Peters, Matthew, Pfeffer, Paul E, Popov, Todor A, Porsbjerg, Celeste M, Price, Chris A, Rhee, Chin K, Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E, Zangrilli, James, and Price, David B

Abstract

BACKGROUND: Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical features and outcomes of severe asthma in order to facilitate personalised and targeted care. The International Severe Asthma Registry (ISAR) is a multi-country registry project initiated to aid in this endeavour.METHODS: ISAR is a multi-disciplinary initiative benefitting from the combined experience of the ISAR Steering Committee (ISC; comprising 47 clinicians and researchers across 29 countries, who have a special interest and/or experience in severe asthma management or establishment and maintenance of severe asthma registries) in collaboration with scientists and experts in database management and communication. Patients (≥18 years old) receiving treatment according to the 2018 definitions of the Global Initiative for Asthma (GINA) Step 5 or uncontrolled on GINA Step 4 treatment will be included. Data will be collected on a core set of 95 variables identified using the Delphi method. Participating registries will agree to provide access to and share standardised anonymous patient-level data with ISAR. ISAR is a registered data source on the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance. ISAR's collaborators include Optimum Patient Care, the Respiratory Effectiveness Group (REG) and AstraZeneca. ISAR is overseen by the ISC, REG, the Anonymised Data Ethics & Protocol Transparency Committee and the ISAR operational committee, ensuring the conduct of ethical, clinically relevant research that brings value to all key stakeholders.CONCLUSIONS: ISAR aims to offer a rich source of real-life data for scientific research to understand and improve disease burden, treatment patterns and patient outcomes in severe asthma. Furthermore, the registry will provide an international platform for research collaboration

Published
2020

245. International Severe Asthma Registry: Mission Statement

Author

Canonica, G. Walter, Alacqua, Marianna, Altraja, Alan, Backer, Vibeke, Bel, Elisabeth, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Brusselle, Guy G., Christoff, George C., Cosio, Borja G., Costello, Richard W., FitzGerald, J. Mark, Gibson, Peter G., Heaney, Liam G., Heffler, Enrico, Hew, Mark, Iwanaga, Takashi, Jones, Rupert C., Siyue, Mariko Koh, Rhee, Chin Kook, Lehmann, Sverre, Lehtimäki, Lauri A., Ludviksdottir, Dora, Maitland-van der Zee, Anke Hilse, Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Plaza, Vicente, Perez de Llano, Luis, Peters, Matthew, Porsbjerg, Celeste M., Sadatsafavi, Mohsen, Cho, You Sook, Tohda, Yuji, Tran, Trung N., Wang, Eileen, Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Le, Thao L., Murray, Ruth B., Price, Chris A., Price, David B., Allergy & Respiratory Diseases Clinic - DIMI, University of Genoa (UNIGE), AstraZeneca, Luton, United Kingdom of Great Britain and Northern Ireland., Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), UBC and VGH Divisions of Respiratory Medicine [Vancouver, BC, Canada], St. Paul’s Hospital - University of British Columbia [Vancouver, BC, Canada]-Institute for Heart and Lung Health [Vancouver, BC, Canada], Dipartimento di Scienze Mediche, Università degli studi di Torino (UNITO), Royal Brompton Hospital, Lung Division, London, United Kingdom of Great Britain and Northern Ireland., AstraZeneca, Gaithersburg, Maryland, United States., MedScript Ltd, Aberystwyth University, Division of Infection and Immunity [Cardiff, UK] (School of Medicine), and Cardiff University

Subjects
Pulmonary and Respiratory Medicine, ISAR, severe asthma, DEFINITION, OMALIZUMAB, [SDV]Life Sciences [q-bio], Medicine and Health Sciences, PHENOTYPES, ADULTS, Critical Care and Intensive Care Medicine, Cardiology and Cardiovascular Medicine, COSTS, PREVALENCE
Abstract

International audience; Regional and/or national severe asthma registries provide valuable country-specific information. However, they are often limited in scope within the broader definitions of severe asthma, have insufficient statistical power to answer many research questions, lack intra-operability to share lessons learned, and have fundamental differences in data collected, making cross comparisons difficult. What is missing is a worldwide registry which brings all severe asthma data together in a cohesive way, under a single umbrella, based on standardized data collection protocols, permitting data to be shared seamlessly. The International Severe Asthma Registry (ISAR; http://isaregistries.org/) is the first global adult severe asthma registry. It is a joint initiative where national registries (both newly created and pre-existing) retain ownership of their own data but open their borders and share data with ISAR for ethically approved research purposes. Its strength comes from collection of patient level, anonymous, longitudinal, real-life, standardized, high-quality data (using a core set of variables) from countries across the world, combined with organizational structure, database experience, inclusivity/openness, and clinical, academic, and database expertise. This gives ISAR sufficient statistical power to answer important research questions, sufficient data standardization to compare across countries and regions, and the structure and expertise necessary to ensure its continuance as well as the scientific integrity and clinical applicability of its research. ISAR offers a unique opportunity to implement existing knowledge, generate new knowledge, and identify the unknown, therefore promoting new research. The aim of this commentary is to fully describe how ISAR may improve our understanding of severe asthma.

Published
2019

246. Sudden neck swelling with rash as late manifestation of COVID-19: a case report

Author

Giannitto, Caterina, primary, Bonifacio, Cristiana, additional, Esposito, Susanna, additional, Ammirabile, Angela, additional, Mercante, Giuseppe, additional, De Virgilio, Armando, additional, Spriano, Giuseppe, additional, Heffler, Enrico, additional, Lofino, Ludovica, additional, Politi, Letterio Salvatore, additional, and Balzarini, Luca, additional

Published
2021
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247. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life

Author

Bagnasco, Diego, primary, Povero, Massimiliano, additional, Pradelli, Lorenzo, additional, Brussino, Luisa, additional, Rolla, Giovanni, additional, Caminati, Marco, additional, Menzella, Francesco, additional, Heffler, Enrico, additional, Canonica, Giorgio Walter, additional, Paggiaro, Pierluigi, additional, Senna, Gianenrico, additional, Milanese, Manlio, additional, Lombardi, Carlo, additional, Bucca, Caterina, additional, Manfredi, Andrea, additional, Canevari, Rikki Frank, additional, Passalacqua, Giovanni, additional, Guarnieri, Gabriella, additional, Patella, Vincenzo, additional, Maria Pia, Foschino Barbaro, additional, Carpagnano, Elisiana, additional, Colle, Anna del, additional, Scioscia, Giulia, additional, Gerolamo, Pelaia, additional, Latorre, Manuela, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Favero, Elisabetta, additional, Iannacone, Sandra, additional, Savi, Eleonora, additional, Montagni, Marcello, additional, Camiciottoli, Gianna, additional, Allegrini, Chiara, additional, Spadaro, Giuseppe, additional, Detoraki, Caterina, additional, Galeone, Carla, additional, Ruggiero, Patrizia, additional, Yacoub, Monna Rita, additional, Berti, Alvise, additional, Colombo, Gisella, additional, Scichilone, Nicola, additional, Durante, Carmen, additional, Costantino, Maria Teresa, additional, Roncallo, Chiara, additional, Braschi, Mariachiara, additional, Blasi, Francesco, additional, D'Adda, Alice, additional, Ridolo, Erminia, additional, Triggiani, Massimo, additional, Parente, Roberta, additional, Maria, D'Amato, additional, Verrillo, Maria Vittoria, additional, Cristina, Zappa Maria, additional, Lilli, Marianna, additional, Crimi, Nunzio, additional, Bonavia, Marco, additional, Corsico, Angelo Guido, additional, Grosso, Amelia, additional, Del Giacco, Stefano, additional, Deidda, Margherita, additional, Ricciardi, Luisa, additional, Isola, Stefania, additional, Cicero, Francesca, additional, Amato, Giuliana, additional, Vita, Federica, additional, Spanevello, Antonio, additional, Pignatti, Patrizia, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Aletti, Eleonora, additional, Massimo Ricciardolo, Fabio Luigi, additional, Anna Carriero, Vitina Maria, additional, Bertolini, Francesca, additional, Santus, Pierachille, additional, Barlassina, Roberta, additional, Airoldi, Andrea, additional, Guida, Giuseppe, additional, Eleonora, Nucera, additional, Aruanno, Arianna, additional, Rizzi, Angela, additional, Caruso, Cristiano, additional, Colantuono, Stefania, additional, Arcolaci, Alessandra, additional, Vianello, Andrea, additional, Bianchi, Fulvia Chieco, additional, Marchi, Maria Rita, additional, Centanni, Stefano, additional, Luraschi, Simone, additional, Ruggeri, Silvia, additional, Rinaldo, Rocco, additional, Parazzini, Elena, additional, Calabrese, Cecilia, additional, Flora, Martina, additional, Cosmi, Lorenzo, additional, Di Pietro, Linda, additional, Maggi, Enrico, additional, Pini, Laura, additional, Macchia, Luigi, additional, Di Bona, Danilo, additional, Richeldi, Luca, additional, Condoluci, Carola, additional, Fuso, Leonello, additional, Bonini, Matteo, additional, Farsi, Alessandro, additional, Carli, Giulia, additional, Montuschi, Paolo, additional, Santini, Giuseppe, additional, Conte, Maria Elisabetta, additional, Turchet, Elisa, additional, Barbetta, Carlo, additional, Mazza, Francesco, additional, D'Alo, Simona, additional, Pucci, Stefano, additional, Caiaffa, Maria Filomena, additional, Minenna, Elena, additional, D'Elia, Luciana, additional, Pasculli, Carlo, additional, Viviano, Vittorio, additional, Tarsia, Paolo, additional, Rolo, Joyce, additional, Di Proietto, Mariacarmela, additional, and Lo Cicero, Salvatore, additional

Published
2021
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248. A Responder Analysis To Demonstrate Dupilumab Treatment Effect Across Objective and Patient-Reported Subjective Endpoints For Patients with Severe Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)

Author

Bachert, Claus, primary, Peters, Anju, additional, Heffler, Enrico, additional, Han, Joseph, additional, Olze, Heidi, additional, Pfaar, Oliver, additional, Chuang, Chien-Chia, additional, Rout, Raj, additional, Attre, Richa, additional, Goga, Ledia, additional, Jacob-Nara, Juby, additional, Rowe, Paul, additional, Deniz, Yamo, additional, Chen, Zhen, additional, Kamat, Siddhesh, additional, and Siddiqui, Shahid, additional

Published
2021
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