201. Combined use of creatinine and cystatin C improves the detection of renal dysfunction in children undergoing home parenteral nutrition
- Author
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Lucie Matrat, Anne-Laure Sellier-Leclerc, Emmanuelle Ecochard-Dugelay, Mathias Ruiz, Laurence Dubourg, Noël Peretti, Sophie Heissat, Irène Loras-Duclaux, Pierre Poinsot, Stéphanie Marotte, Justine Bacchetta, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Service de Gastroentérologie, d'hépatologie et nutrition pédiatrique [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Robert Debré, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Edouard Herriot [CHU - HCL], and ROSSI, Sabine
- Subjects
medicine.medical_specialty ,measured glomerular filtration rate ,Adolescent ,estimated glomerular filtration rate ,pediatrics ,030309 nutrition & dietetics ,Urology ,Medicine (miscellaneous) ,Renal function ,Context (language use) ,urologic and male genital diseases ,home parenteral nutrition ,Nephropathy ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,intestinal failure ,medicine ,Humans ,Cyst ,Cystatin C ,Renal Insufficiency, Chronic ,Child ,Retrospective Studies ,0303 health sciences ,Creatinine ,Nutrition and Dietetics ,biology ,business.industry ,Retrospective cohort study ,medicine.disease ,3. Good health ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,Parenteral nutrition ,chemistry ,Child, Preschool ,biology.protein ,030211 gastroenterology & hepatology ,Female ,Kidney Diseases ,business ,Parenteral Nutrition, Home ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,chronic kidney disease ,Glomerular Filtration Rate - Abstract
International audience; Background Renal dysfunction can complicate home parenteral nutrition (HPN). The aims were, in the context of pediatric HPN, to assess renal function using the measured glomerular filtration rate (mGFR), determine the most accurate formula(s) to estimate GFR, and identify possible underlying mechanisms of renal impairment.Methods A retrospective study was performed in 2 centers. Patients receiving HPN and aged 2-16 years without medical history of nephropathy were included. GFR was measured using iohexol clearance. Estimated GFR (eGFR) was calculated using creatinine, cystatin C-based, and combined (eGFR(cr+cyst)) Schwartz formulas.Results A total of 36 patients (18 females) were included; they received HPN for 8 (2-16) years. The primary digestive disease was short-bowel syndrome for 16 (44%) patients, gastrointestinal motility disorder for 10 (28%), or congenital diarrhea for 10 (28%). The median (range) mGFR was 99 (33-136) ml/min/1.73 m(2); 9 (25%) patients had mildly decreased mGFR (= 60 ml/min/1.73 m(2)), and 2 (6%) had mildly to severely decreased mGFR (
- Published
- 2021